Document wo1787Z9XBKvjXq2LZ0nKZE3

Nr. R. A, C lslbet Bakellte Company Third Floor 9 East 41st Street November 1954 Dear Mr. Calsibetl We ars returning your file of correspondence frost the Surface Engineering Company, Inc. X would not think It would be advisable to Identify Bakellte with this use of vinyl. We would not even suggest the utilisation of vinyl resins for permanent implants in the human bod/. To our knowledge, there has been Inadequate information on the safety of such applica tion and usage. In fact, there have been published! "Sarcomas Induced in Rats by Implanting Cellophane," by- B. S. Oppenhelmer, Enid T. Oppenhelmer, and A. P. Stout, PROCEEDINGS OF THE SOCXETT FOR EXPERIMENTAL BIOLOGY AND MEDICINE, Volume 67* pages 33-4* 1948. "Sarcomas Induced in Rodents by Imbedding Various Plastic Films," by B. S. Oppenhelmer, Enid T. Oppen helmer, and A. P. Stout, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, Volimw 79* pages 366-9* 1952. In this work in which films of various plasties, including vinyl, were Implanted in rats, a percentage of the rats developed sarcomas (malignant tumors) at the site of the implant. Doctor 8elf's work, as reported In the letter of November 1, 1954 from N* T. Thompson, represents an inadequate piece of work to establish safety In such usafce. Animal obser vations should be for at least one or two years, and dogs are not good subjects to demonstrate adverse effects such as tumors eta. Very truly yours. MEDICAL DIRECTOR ' INDUSTRIAL MEDICAL AND TOXICOLOGY DEPARTMENT Thomas W. Male, N. D. ucc 063338