Document wjJgGkgzJLn54Mz66qE0D0Ld

INDUSTRIAL HYGIENE FOUNDATION OF AM ERICA. I N C. ! PLAINTIFF'S EXHIBIT MXLLON InTITUTC, 4400 FIPTM Avf.HUI PlTT*UOM, PA. IS3I3J April 15, 1965 Mr. Leon Horowits Mr. C. L. Shcc'xisr Mr. F. M. Cdwardo t3r. Lee B. Grant Dr. J. H. Wolf le Cartain-'ceed Products Corporation Johns-Manvillo Corporation Ov/en*-Corning Fibergias Ccrpdrttiaa Pittsburgh Plat: Glass Company U. 5. P,ubber Company O fr tn Attached ia an Industrial Hygiene Foundation asbestos and Cibrelara threc^yeir research project proposal incorporating suggestion* mads y those listed above vho attended a research planning meeting in niy office a April 1Z, 1965. Also enclosed t a contractual 2grj:.v.ir.s in an orli v?' s w d ^ * f *1 rv'u copy:; in ths event that sponsorship ct thi^ prcneci, is : cpr1cv.'.d, beta should y ti i j gnadj the carbon returned and the original retained i or the aponeor'u i i 1 -. J jrscore 1 y y o u r x, 7?dfl Hobart?. p, deTreville, M.D. Htiii "! > D i v c t c s :c;c !r. sic acres cc: Mr. Marshall Surch, O'-tens-Corning Fibcrg Co nor;, tinn Dr. G. 5. Tashcp, Cwsr.B-Garnirsj hibtrjiaj Co.y.;, -Aon AV ' // . IMOUeVClUVa. S/eiEW5C FOUNBAYJOM OF A.-.{SRIGA#INC Ml5iW IWtfVSWTCl. <*<$ FjPTW ^!tMUC f PT7swecw, Pa. issis A>ffiA ASV PffOS>e8Wi3 ios1 Aa &av3ii$vUlon of: ft. ThJt Srs*c^t44v af Aa>bs<8 Bodi-ca &&. .b# 'S'^.'S &&$ o T?eca ^cfcaUuss*# wish Ckcrysosti* AcfoosS-so. zests sductzo?* $ ?.t. er!i.EE?39*a'' `y H<r.saai3i ]fca<s &*ra4 St/i? fcha tiias hx.& di #4 la ii'. $S$Ji (gs^ceswav sK*ijyiwi:J *d t:.fc^*3V.&s .S^c.ue5''< ^. iJ A-;.?'?-v56 V"':.* iVii?:S4 *',/ * Stro.V'^.ff wS 'V.3?'.a8 tS* ^45'4>r*A &s&fea Uz Salift-al, IHetfi&ft. G&v-aa, 7^5siv>a eaid t'.J ?&*-* `"* ' ^.VCi;(-`! f?)i ;, L;3 &4-a-0.'Jl,*C '.JC\ .iC.w--f*.?U-.i &XS&.3 i'iT '^Msi v !;uSv4 ir.aA a-^i&taiadc `.teas -SC^. ;vT i. ?''**.<' i:-1.Jo Wti 'I'i'ifc 3 fc*S^':v afJ&Waiiiy 2>l& A -f/J yg ..'VrtL.' :` '. ^->Mh.:; J. is, ft.a ' ?.".;j'ivz,'f.\';)t dcui1; ".'.r.j.*, *:* si:, i-o^'.-se*1 irs :: .-it. LSI* i.vav"*. iCoya c-r:f UiMJ <?! 5..: ti'**:.*:'; '.Veil ?---t-.M{! * hfcVS bs=*'U /cv^.4 in c<>5-i rTji-jiv/a a-ax 'rr^tK.srf'* *?>.** <&/ iu v.s >,,'**r. cfcllad b*-f;*^^jCvV.aily Davie**'' me. >1 'axv tcosii'ju'j-.y d'.iV?-lcpaaif:iJ j..-i ^.v-vaa-re* -'* * -`\i ,:'-..v.v .'.i.:-v to "m.-rcLa jo v. . j.fc>r#\'."%**;: Lj ya\1 Cv* .'. s x-rx>'^.wri> * :><.> <r>.>>1 IHT/yCW*!*-.!. M7kl>!tM fOUMOAVJOM AMCRIO 2. Asbavioat ccupUe aa viicimalowo poaltloa la Its ability b produce iu$ damog*, causing dlifua* fibrosis a wall no th production d irnsg caacr IS ie caoresxlo\i3 Inasmuch &a a &*? sillctt* hxa boon ehuwa t pso99 this cblilty, Tbs lbreta ocouatorod la bUcosle (e llnilftad So th tromollt va^Usy, which le acboztoeoiifc, a tha thasr hand, a ;^<auracnlfll9 osaoclatoa with iha srtdsiitg mica &!&* oillsil*) kfc aac* &'M lav$ti*s&tod Kp*ffti&fcaiSy<. aa-i ths likfevs^'ikie activity s' dusSa cookIi>ii&s with the mica fcx act bo&a -iVAluatud. 'Tiihsff aillcafcoa may tsyefet) It** cwlalssal r #slativ.ily slight Is^laaattfcatoffy s'coagoc, And eorrtnisiAy atr Iscapcbi producing luag sane:?,, fib eoffsale polycyclic hydroctffbcao *ad tr&cs tsoiAls kaw to b'3 ?i^is~5 *ftsicoff"ps,idua*lar hsv boa doeFtoaslir&frtd la aib9t tjs-sptic^ljfS'i./ stick! ft&d hcaaooyrsac*, poaalsiility <iis$s> <&a* *& %7&e j.'.-sM-l vs,s/ ;-r polycyclic Ai'^cavboa .nay s>c*!y :4>3>v*<*fc pasiw^alciiy. I?.-* v-j* / `i*hle 7-f.#lfeiUSy ii oc^Siri-ssa by /lailavjsj ."`La ifi Srsua-. ulA \Z-z\-jd*:j which toil 5*1*6 4hx5 th ;.?yrfi* /.vac* id iua?j c-itscs* tiis-ng C-s-iaiUta *-s>62usx ssi&fcsi. *?;a sc. 5 s-sates thsa v\ :lv.: /.As.<j.'i ^opaiisioa, TThi? was Is noafrart <o tv y>vov'-; -rt I?c-IL,1'C'' "rhiUih V: iici.lo'd a Xi<'r.'ily !sj?rriaa & iasg sta^ti X rt'il :.1 o .id to ,*.i*;aifto whili .''a *..(.c-'j r.l^s at j/jt9^* 2, la ^c.vas iaavoasl js^vva la tbs itboffatosy *hv ^dx\tri!>d Hycl-c.^ ^'t''.vitiv/-'a-a(, Ux.g cttit.vffo w*fo :'**,^. la sctA 3pa*4i ivw li to Mga :j!ac4y- f.tU^o c cLry ci'.-:ru0 ^^ *.*d jo *hryotllo ^.v.-r. r. j. -. ' !":' ill;-St iilcAi !-.*. cV>-f#.\Op f.kU^tV; .\*Je J,0 a .Jiii V.* Ivj.l: ' c`. ? f I MOUfcTHtAi. HYOICKJt fOWMDATlOf! . AMERICA, ICIO. 3, that the chayectlle du*t that produced lung ctmcer was ei^niilcnatly duCIersat from that which did not have this efiact. It Ifi l&eiy that ihle difference Is ceueed by & costing o nickel steal riloy Applied So tha aabestea dust pestlelofl during the continuous hammer tr.UUag procoss used far rendering the duet sacgiirabie. This method has nai bea used by lavs^tlgnSoro. Nickel hsft aouad capable of producing Ivsiag e&ocai? la trace aan^vvate. Althoush nubeetoe sad gta^e are both alUc.t9 the Lutluctrlal health eswiriykiac workers ei two Baatsslaia mla b**M vastly different. Kit pulraot-as'y iCiaoas* has beea x'cspoxrSad la r,'3ffko>rsi erased i& jlass dust *JoY$-rjasl-% .{& duaS ^ fUs'Kaaiatm'j gl-nao !wi<s baea labalad -a hlgHf ri?>zi%?<it-?,-;it) K% the iiy yvserc by Aa<*cteftiaei with &cb<m*>o, bi id a i?.ei tbt t*w .vii* -st s-I ;Tlolia glAOSi cvwt oa she A'Cttiv?# *x &<&&&!: h&3 be aa s-upsa&vA t*'.i> r'.A7.;-i,.V'.f ^ .1 :'. has ci***<3 &ib*b *2' tivs ditcJ *c :&!< Mis*--W: <$>? Stiles'c . wisk&o1* nigt / c*rT: i a-%-'**-..V'n.*T>x.*T`1v**f?h*i* S Z.'&Cj ji x Ms U y.rz;**;<& ;>** sa,a-i.'oi.'i..n sha u'i ^ .S-V' dlaiis-as# - fr.alc /u'rwj v hi .'/v::t'r.!i.j ...cinvsci*>s;ua, .-k1 So t 2i>:r'i*r- :.* <'/.** it exS-eo a ' ..'b.tri. - fj. :.* ;>*&.*, It U 'Iblxse a. to iivc'j-.l-<;s.tt the t-aii-coce ti S;-*c* oi?.e.Tel aa! pi-ly1 X ;;;.lir: .V.yhr noA-r;-^ss (i, a,. ^ren^c-yi'C'-ce) s^ocitie-3 ~'lth ae&estovi ore os :';*. c--.'=:: ^c.-; c*a Ui..i .:.-i*.n-SQ;.-aa V h : v-T^-.-a <C-' i'<.'-T.j 6'- i.b* i'.U: INDUSTRIAL HYOICMC roUNOATION >< AXKHICA.INO. 4 Another objective of Ihl* phase la to obtain definitive data oa the long* t tsstn effect of dust derived from filamentous gl&ec upoa the lua$a Three . * varieties of euch glass dust will be InveotlgntedS * 1. with tho ph*noi'formldehyrietyp of binder 2. vlfch the binder used In textiles 3* vitiimt tfcda?. ** I . t . ....... 1 , ' ^T.^RIALS AND METHOD Fhc.se 1, The following fibrous materials will be reduced to respirable particle slae end will be Injected In amounts of 3.3 taj. to 30 mg. so acuacnis euepeions: 1, chrye^tlls dust (prepared by milling la Wright mill and "adih demon* strated carcinogenic potential) 2, chiryffo^iie rkrat (uamtlled synthetic.)* 30( aluminum nitride '4, trlcalcium phosphate (fU/unantouo) / 5. flhroui' c'iac a.' with phenol "formaldehyde^t/pa binder bc with binder used for teiuhieo c, without biudei* 6. t^xgnecluua hydronoa (brucitc) 7. f/ool 3, tine ordf'a (filamentous) There uflfitrtriaiff will be Ujecie-i intraaaoheiuly itrto k-zuHc-t s:l\zr xesih:`#ia. Previcu* crrpcriTiica \,*,r demonstrated, that nsber.Uo bo;Us wU form In sres^ajo to ehry r.'jt/l* cu:aS T/.thia five tucalhv, Tha ar,l.r...lj w-vli Churn ?.nz<i be held for elx vr.ontns -fcr.d thou killed. The lvn^s \?iU ha sKp&nc.nd xrlth buffered formalin uudex a ha*.<i oi *.0 ,,\? \;ptr,\*, ^.IacUs vc.r.'ovo.i :.'f*.n the so \`\np,r \rill he r<ecU<..'.r..i 'jS- SyoL\'.*ilU: ch.'fyeotll* ~ao tw.en prepared at .Wriloa Institute by C.r. William Gran^ulrt,. El-:, c trim r*. ;oc.vtcrJt>o'v ihc charct*\Isllt c.r*- 'WCl'X'fWA!.' HYOirXt VOUnOATtOM ^tfllCA.IMO. .. 5# fdter paraffin Impregnation. Thej* sections will be eiaiaed by different 'methods and photographed sequentially to provide means for studying more completely the tissue reaction to these varioue materials. Search for the 0o~c&ll4<t asbestos bodies vrlil be made using routinely stained sections, and aacttanw et*ia*d for iron, In addition, unstained cleared sections will be '^f.rnined ua-3*r earh-iicid cn&tio&a for asbestos b&dlee. She tatter glow .vhiis tn tils -z:,.anuer. !X~i^ .vJl'SU%e?aiie k. itasufc r-sActian b*t>rs>Li the ayuinstic chrysotlle duot aud 'i-'-'-i is> Icaova to f.\hrgenic *us ?sU to carcinogenic will vj> c,.s c uctyiinali-aji io pa&tjr salsify ma-tia Vy-asie sr snore -of the various i-,>*v,:,t.-; may be *.?*> taxed with ii.fcrv*scfciij asbestos dust as a '.VI1;.- .!.j.vr:.c^<r2i< .*< bodl-sr*", bv;t*y $ra6 bodies ;\vi.'i} k' ;* y ;hs: 5iSb!>.?,tO would point ": the uon.*pfe*;fSit*ty os . \oc 4. *. >: ::r..~v.s <. &s.t *l-. the i.c'iiiy of sa c.vta% sv.cO ^hahesvcs bx;ta,tr' :V...r. /.v.rr.ic. iss <*-'ce7 Ms tr.bjact them 1 *<;::-os-or ces ..cmirt-t*. s-2.>y-n.* ;r>ui<> <ri"--9 lodorraukU&a wa regard to the ct. sail cal make-up ci Jha ttu>ct ----- Ibta '.-is &..* dtv-vxV.trjac.i v.1 Sr.o fi:'rt:: i> ^.v-t b- . 2. li> to v/tx--^icr<* h <. cL-IoyA :.; :'o.U of the vinous co;m rstr.tfl et o/iryiotlla .McbeMcs in the produclloti o/ Ixig fibre!* end lc-ny cmccr, edit i.vrtai of vc.11 -7ill be injaetto. L'llr^trcthcally with 1 ioli ovrtijg: ). z i'. r.-rt Icicvr.i re be cr.ro :r.r/wii r. v "v < 1-. ** # 1.0 Cl --** l- ~J t L <J8 IHOUSTRIAU HYOICNC /'OUNOATIC' r am iica.ino. 3. synthetic chryaotlle plus nickel 4. synthetic chrysotile plus nickel, plus bensopyrene 5. nickel alone or with carbon as carrier 6. bensepyreno with carbon as carrier. 6 These rats will be held for two years and then killed. The lungs will be prepared for examination and sections cut In the same manner as in Phase 1. Thrao oilier series ol rats will be injected Intratracheaily with the following dusts: 1. filamentous glass with phanol-formaldehydc-type binder 2. filamentous glass with the binder used for'textiles 3. filamentous glass without binder. These animals will also be held for two years and then killed. The lungs will bo prepared and studies as in the preceding groups. The number of animals per series win be such that there will be no doubt regarding the statistical significance of the resaltr. ' REPORTS A progress report giving the roe-aits of Phase 1 will be submitted at the end of 12 incnths, ' An interim report on Phr. e 2 will bo submitted at the end of 24 tnoDths, and e final report will bo submitted at the end cf tbo third year. COST The cost of this lnvaat.'.ga<ion Is $10,0C0 per year for three years, or $30,000 for each cf tho five participating companies. IfcDU&THtAi. KYeiCNt-rCUKCATlOH AMCTWOA.IMO. SUPERVISION Research will be performed under ths direci supervision of Dr. Paul Gross, Director of the Foundation's Rossarch laboratory* The Foundation's studies oa asbestos presently ara being conducted under partial support of the U.S. Government through a National Institutes of e Health grant and a contract with the U.S. Public Health Service, Division 'of Occupational Health (Dr. Lewis J. Cralley). A list of Dr. Gross' publications in the pathology of pulmonary diseases, and a membership information booklet describing laboratory projects presently in progress, are attached. / \ $ r ; * ih,-:.' UrrUAC MYa>KKC rOUH4?ATIC l r amkmoa.ivc. 4 . -..y * -V t 1. Thomioai J. G. i Ktichult, R. O. C. ud MacDonald, R. R. AtlxitOl *. Modern Urban Haserd. S. Afr. Mad. J. 36:759. 1962. 2. Them con, J, G. Asbestos and the Urban Dwollor in 3Iolo?ric Drfrfoett oi Asbaatos. Annels erf New York Academy ci Science* .1 1965. * .3. Cauna, D., Totten, R. 2. and Croat, P. Aebeetoa Bodies In H'roua euji|{a at Autopuy J A* 24. ,& 1371, 19o3. V 4, Y/cbattr, L and Catted aid*. "lacldeace of Asbestos rbcporure,'f pr. 24*23 Awutl Report on Metical Ecaearch 1963*1964. C31R Special Report# Pretoria, S. Africa, l'lr`63, '* 5, Davis, J. M O. Electron Microscopic Gtudiao orf Aabeetocia la i&aa and Animals in Diolcoric DKocta ai Asbestos, Ann-sle orf New York Academy c< r.i.tmc 1 l: V 8, 1965. 6, Collet, A.. Porscnal eor^tnvsiic&ticsi to Dr. Gross, 1964. , 7. ?trr\?n, D. C. <r.<i Tnta, T. D. *VM:nio*o:lcal Scndy orf vL^n: C-vstt? in A.'i'nectoa Minora, Arch. Xackvot, i-.C^sDui 17:634, IV63. / S. Doll, Diorvalit'p rfrotn I/iRH **1- v> *-: *- < 'k) 5 ** 4!^ v vta ^ *> > l j iti Ashefctoe Worhoro. ,3?.'1. J. Grose, P, w.H dsTrtndllo, 21. `D, { to bn vr.bU*>ld, ? ,. , * * VI * l V.