Document wgdYObQGOQEvjaYjNVjXQk76

FILE NAME Synkaloid SYN DATE 1978 DOC SYN027 DOCUMENT DESCRIPTION 1978 Journal article on lung cancer in drywall taping worker Citation Alf Fischbein Arthur M. Langer Yasunosuke Suzuki Irving J. Selikoff 1978 Carcinoma of the lung in a drywall taping worker report of a case Toxicology Letters Volume 2 Issue 4 Pages 231-236 https://doi.org/10.1016/0378-4274(78)90072-3 Toxicology Letters 1978 231-236 'Holland Biomedical Press 231 CARCINOMA OF THE LUNG IN A DRYWALL TAPING WORKER REPORT OF A CASE ALF FISCHBEIN ARTHUR M. LANGER YASUNOSUKE SUZUKI and IRVING J. SELIKOFF Environmental Sciences Laboratory Department of Community Medicine Mount Sinai School of Medicine of the City University of New York Fifth Avenue and 100th Street New York NY 10029 U.S.A. Received June 14th 1978 Accepted June 29th 1978 SUMMARY Squamous cell carcinoma together with pulmonary asbestosis is reported in a drywall taping worker In this trade vigorous sanding of dried taping compounds produces a dust which is known to contain chrysotile asbestos Fibrils of chrysotile asbestos were seen on transmission electron microscopy of ashed lung tissue The authors emphasize the need to institute adequate preventive measures in this trade INTRODUCTION New industrial processes may considerably widen the range of occupational health hazards Drywall construction was introduced in the United States on a large scale basis immediately after World War II During the past two decades drywall construction has achieved a dominant role in the United States con- struction industry This trade has recently been described by us in detail and has been shown to be associated with significant asbestos exposure 1,6 The occurrence of a pulmonary carcinoma in a drywall taping worker with the finding of very large numbers of asbestos fibers in the lung raises the possibility that this trade may soon become the source of asbestos neoplastic disease in addition to asbestosis Dust diseases of the lung may be diagnosed in different ways and with various degrees of accuracy In order to achieve definitive diagnosis the identification of the hazardous agent is required The substance may be found in the material used in a work process in air samples or in human tissues as a result of exposure : Supported in part by Grants from the National Institute of Environmental Health Sciences ES 00928 and the American Cancer Society 53C 232 We report here a case of lung cancer in a drywall taping worker as well as the results of tissue analysis for asbestos fibers and other inorganic materials The importance of utilizing adequate techniques for tissue analysis is stressed CASE REPORT E.S. a year white male was admitted to another hospital in May 1971 because of weight loss chest pain and sudden hemoptysis Two weeks before ~ an a chest radiograph had shown infiltrative process in the left upper lung field 7~ This persisted despite antibiotic therapy and the patient was admitted for a further study ew Bronchoscopy was negative for malignancy and cytological examination of bronchial washings showed only atypical cells Scalene node biopsy was un- remarkable A left upper lobectomy was performed A portion of the fourth rib was adherent to the pleural surface on the anterior lateral aspect Section of the lung revealed an area of grayish consolidation beneath the rib adhesion Macroscopically the area was suggestive of a neoplastic tissue There was no involvement of the lower lobe The patient was followed for 1 year as an out- patient developed symptoms suggestive of cerebral metastases and died on May 23 1972. No autopsy was performed Past medical history had been un- remarkable The patient had been a smoker and had been a drywall F construction worker for 25 years mixing applying and sanding various spackling and taping compounds Histopathological examination The tumor tissue in the surgical specimen from the peripheral part of the lung F F A w E Fig 1. The peripheral part of the lung is shown with thickened neoplastic tissue and fibrotic alveoli 270 x ll as erials ressed May 1971 efore ng field or tion of un- ourth ction hesion as no in outon en all the lung 233 al , e te ^' *s oa % oY + P @ re ^' dyr - ee aw Tae A PF Oem $ eFe ys OSG ry 6 3 7 - ~~ ] . \* Ne * e's get ~ a we. S Ga ok, ye 44 Ra S5e \ Oe Re ee Mpeg SB Be7e) Le MES Pa oS NEO A ' fer OBS (Koa iy Diet Fer ie ~ 08? wt} .Reset. %% @ eo. arya a e oa 50 Rae ~~ oe TS a7 90S ot Pate wow -. & Ha, Fe & 3 ae OF SO 0F.e; o Fig 2. Tumor tissue with pearl formation 1700 x was a differentiated squamous cell carcinoma Fig 1 The neoplastic cells were irregular in shape and formed nests of various sizes Occasionally pearl formation was observed Fig 2 Polymorphism atypical features and abnormal mitosis was remarkable There was invasion of the tumor into the pleural region with much fibrosis In addition to the neoplastic changes described above the pulmonary parenchyma showed congestion edema and pneumonia which was partially organized Alveolar macrophages had accumulated in alveolar spaces Hemosiderin and anthracotic pigments were frequently seen in the cytoplasm i of the macrophages | Of interest was the presence of pulmonary fibrosis in the form of alveolar septal Fig 3 and bronchiolar fibrosis This fibrosis consistent with pulmonary asbestosis was not accompanied by the finding of asbestos bodies either in the alveolar space or in the fibrotic tissue itself Mineralogical analysis of lung tissue A ...mthick unstained uncovered tissue section was prepared for electron microscopy by the carbon extraction technique 4 The prepared specimen was examined by transmission electron microscopy utilizing an RCA EMU Scan magnification ranged from approx 2000-31 000 x At magnification greater than 15 000 x particles too small to be seen by light microscopic methods became visible The appearance of numerous particles by electron microscopy invisible by all other microscopic techniques has been described 5 Everywhere in the relic tissue numerous particles were observed Fig 4 | Sheet silicates diatom fragments and chrysotile asbestos were observed in 234 nea fibe ogi cry difi the the par rep cor wit an 8 str wo eva de the we str 35XF/ 35XF/ 35XF/ 35XF/ 35XF/ 088359288 088359288 088359288 088359288 088359288 088359288 088359288