Document wgOw9RLNaDxzZo68Nbdbg3RJd

November 16, 1994 ChemRisk A Dms/on or'McLatvnHatf 4105 Chelsea Ct. Midland, MI 48640-3361 (517) 631-7089 (Voice/Fax) Toxicology & Applied Pharmacology Editorial Office 525 B Street, Suite 1900 San Diego, CA 92101-4495 Dear Dr. Bresnick, Please find enclosed a manuscript entitled "Predicting Cancer Risk from Vinyl Chloride Exposure with a Physiologically-Based Pharmacokinetic Model" which my coauthors and I would like to submit for publication in Toxicology & Applied Pharmacology. Although the manuscript describes the development and validation of a physiologically-based pharmacokinetic model for vinyl chloride in both humans and rodents, I feel the most significant issues address by this manuscript is its treatment of a nearly unique situation: the accessibility of human cancer incidence data to check the validity of some of our techniques for estimating human cancer risk. I have included with this letter my personal check in the amount of $100 payable to the Society of Toxicology to cover the manuscript handling fee. Please address all correspondence concering this manuscript to me at the address listed above. Thank you very much. Sincerely, Richard H. Reitz, PhD, DABT Principal Health Scientist SL 107926