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STN INTERNATIONAL CA FILE SEARCH RESULTS - S64Q722W w-`Ee"' /" 22 7?^ PAGE 51 L31 ANSWER 67 OF 160 CA COPYRIGHT 1996 ACS AN 124:36405 CA _ ?^ ' 01 TI General health of workers in the Novaky Chemical Works exposed to vinyl chloride AU Galikova, E.; Tomikova, K.; Zigova, A.; Mesko, D.; Buchancova, J.; Petriskova, J.; L'uptakova, M.; Jakubis, M.; Karaffova, N. CS JLF, MFN. Martin, Slovakia SO Prac. Lek. (1994), 46<6), 251-6 CODEN: PRLFAG; ISSN: 0032-6291 DT Journal LA Slovak AB The authors examd. 129 employees in the Novaky Chem. Works (Slovakia) exposed to vinyl chloride (VC) within the framework of the Research Task "Monitoring of the Effects of Chem. Carcinogens in Working Environment and the Health of Workers". The mean age was 36.6 yr (19-58 yr), the mean exposure lasted 13.4 yr (2-37 yr). The authors took case history data in view of the work history and theincidence of oncol. diseases in the family history, objective examn., lab. examn. with emphasis to hepatopathies. The authors evaluated the incidence of diseases with possible connection -to work exposure and frequency of non-occupational diseases. The results of the complex clin. examn. and levels of some lab. parameters were evaluated and compared with the data of blood donors from the same area. The mean concns. of vinyl chloridein the air from the measuring spots of "classical anal." under the reactor and in the compressor room in 1990-1993 several-fold surpassed the MAC. It became obvious that the exposed workers were employed in the following occupations: operating machinery (60 workers), repairman-locksmith (46 workers), shift engineer (12 employees), electrician (5 employees) worker in PVC bag filling (5 workers), research workers (one employee). The oncol. diseases in the family history occurred in 9.3%. Cardiovascular diseases predominated (23.3%), followed by diabetes metlitus (11.3%). In the subjective complaints the most frequent symptoms were those related to bone and joint system (16.3%), respiratory (10%) and digestive (8.5%) system. The objective examn. revealed hepatomegaly in 5.4%. Sedimentation of erythrocytes was increased by 31%. There were no substantial changes in evaluating blood count. Lymphocytosis was obsd. in 43.4%. The level of cholesterol, GMT, ALT and AFP were not significantly different when compared with those of blood donors. Hepatopathies occurred in 13.9%. Diseases of respiratory system were obsd. in 10%, diseases of gastrointestinal system (except hepatopathies) and vertebrogenic syndrome were found in the same frequency (9.3%, resp.). Cowigh^W^JSS^^mericar^^hemical^^Soci^^JACS^ STN INTERNATIONAL CA FILE SEARCH RESULTS - S640722W 22 JAN 96 06:36:24 p:U PAGE 50 L31 ANSWER 66 OF 160 CA COPYRIGHT 1996 ACS AN 124:36410 CA 7 S"-u l-H TI Anti-p53 antibodies in sera of workers occupationally exposed to vinyl chloride AU Trivers, Glenwood E.; Cawley, Helen L.; DeBenedetti, Virna M. G.; Hollstein, Monica; Marion, Marie J.; Bennett, William P.; Hoover, Marie L.; Prives, Carol C.; Tamburro, Carlo C.; Harris, Curtis C. CS Laboratory HumanCarcinogenesis, National Institutes Health, Bethesda, MD, 20892, USA SO J. Natl. Cancer Inst. (1995), 87(18), 1400-7 COOEN: JNCIEQ; ISSN: 0027-8874 T Journal LA English AB The objective of this study was to det. the prevalence and time of appearance of serum anti-p53 antibodies during the pathogenesis of angiosarcoma of the liver (ASL) assocd. with occupational exposure to vinyl chloride. Enzyme-linked immunoassay (EIA) was used to detect anti-p53 antibodies in individuals occupationally exposed to vinyl chloride; 15 of these individuals had ASL. It is concluded that serum anti-p53 antibodies can predate clin. diagnosis of certain tumors, such as ASL. and may be useful in identifying individuals at high cancer risk, such as workers with occupational exposure to vinyl chloride. ASI 000013933 STN INTERNATIONAL f-1 U CA FILE SEARCH RESULTS - S301161N 01 APR 96 00:05:55 PAGE 109 L31 ANSWER 148 OF 185 CA COPYRIGHT 1996 ACS AN 124:168010 CA 7*T-0/-V TI The effect of vinylchloride on the morphology of mouse AU Yun, Shumei; Lin, Weici; Sheng, Huiqi ***sperm** CS Dep. Toxicology, Beijing Medical Univ., Beijing, 100029, Peop. Rep. China SO Beijing Yike DaxueXuebao (1995), 27(4), 273-4, 277 CODEN: BYDXEV; ISSN: 1000-1530 DT Journal LA Chinesa AB The effect of vinyl chloride on the morphoi. of ***sperm*** was obsd,, and the mutagenicity-- of vinyl chloride in germ cells was assessed. Vinyl chloride increased the abnormal incidence of mouse --sperm-- , and the main types of abnormal --sperm-- induced by vinyl chloride were banana-like and nonhooked. Dose-effect curves were obtained. L31 ANSWER 149 OF 185 CA COPYRIGHT 1996 ACS AN 124:168003 CA TI --Toxic-- elements in tobacco and tobacco smoke AU Chiba, Momoko; Masironi, Roberto CS School Medicine, Juntendo University, Bunkyo, 113, Japan SO Trace Toxic Elem. Nutr, Health, Proc. Int. Conf. Health Dis.: Eff. Essent. Toxic Trace Elem., 4th (1995), Meeting Date 1993, 32-7. Editor(s): Abdulla, Mohammed; Vohora, Shashi B.; Athar, Mohammad. Publisher: Wiley Eastern, New Delhi, India. CODEN: 62EMAA DT Conference LA English AB The World Health**** Organization states that about 3 million deaths are caused yearly worldwide by the use of tobacco. Much is known about the adverse health*** effects of CO, nicotine, tar, irritants, nitrosamines and other noxious substances emitted in tobacco smoke but not enough attention has been paid to the harmful effects of heavy metals and other ***toxic*** elements present in tobacco leaves and in tobacco smoke. Smoking may be a substantial source of intake of --hazardous-- elements not only to the smoker but also, through passive smoking, to nearby non-smokers. The adverse health*** effects of such ***toxic*** elements on the fetus*** through maternal smoking, and on infants through parental smoking, is of special concern. The literature contains data on Al, As, Cd, Cr, Cu, Pb, Mn, Hg, Ni, Po2'0. Se and Zn in tobacco leaves and in smoke, but only for As, Cd, Pb, Ni, and Po210 there is enough evidence that they may play a neg. rote on human health*** Maternal smoking may entail a potentially harmful decrease in Zn levels in the **fetus*** and the newborn. io^riaht_^_J99S_BAmerican_Chemica^_Societ^_(ACSy AS I 000013934 STN INTERNATIONAL CA FILE SEARCH RESULTS - S640006R 18 SEP 95 03:16:54 PAGE 108 L31 ANSWER 136 OF 167 CA COPYRIGHT 1995 ACS AN 123:135606 CA O? SjT' --i0 / - 'fi ll Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: examples with vinyl chloride and trichloroethylene AU Clewell, H. J.; Gentry, P. R.; Gearhart,J. M.;Allen, B. C.; Andersen, M. E. CS K. S. Crump Group, ICF Kaiser International, Ruston, LA, 71270, USA SO Chemosphere (1995), 31(1), 2561-78 COOEN: CMSHAF; ISSN: 0045-6535 OT Journal; General Review LA English AB Risk assessments of vinyl chloride (VC) and trichloroethylene (TCE) are presented as examples of approaches for incorporating chem.-specific pharmacokinetic and mechanistic information into a more scientifically plausible cancerrisk assessment. For VC, theevidence regarding mode of action includes direct reaction of a metabolite with ONA, resulting in DNA adducts and mistranscription, and cross-species target-tissue correspondence of a rare tumor type. Risk ests. for human exposure to VC predicted with a physiol.-used in environmental decision-making by a factor of 30 to 50, and were more consistent with human epidemiol. data. For TCE, there is evidence of increased cell proliferation due to receptor interaction or cytotoxicity in every instance in which tumors are obsd., and the tumors typically represent an increase in the incidence of a commonly obsd., species-specific lesion. Virtually safe exposure ests. for human exposure to TCE predicted with a PBPK model and a margin of exposure (MOE) approach were higher than those obtained by the conventional LMS approach by roughly a factor of 100. The MOE approach is recommended as an alternative to the LMS approach for chems. with a carcinogenic mode of action which entails increased cell proliferation, leading to the expectation of a highly nonlinear cancer dose-response. ASI 000013935