Document wg7LK5JrpvLDEqZoR0p02o82J

FILE NAME: Chemical Abstracts (CHAB) DATE: 1953 DOC#: CHAB036 OCUMENT DESCRIPTION: Abstract Originally Published in 1952 by Fairhill 1953 2361 . 11H--Pharmacology 2362 H \ tkhge. VHII,asIVm,ucahndatVa.wdoesree oinf a2c5timveg.a/kt gd.oassesIIodfid50a0t m50gm./kgg../ cgoivnecnn.foorf n10ic0odtianyesfrinom0.00.0051 atnod0.02.0M1 Mforn6ic0odtianyessaonlnd. wwheerne I1n2 fmoricIeI,t5h-e6ofroarlIILID,a>nddo>ses1,0ifnorgI.V/kagn.d, wV.ereI, w1a.5s-220 ftoimr eIs, more toxic intraperitoneally than orally. C. D. J. , nineyb:rain--2c0o,rte--x:35;- 1 0--,1-52,2--; 2-68; ,---178, ;--2-27;, a-n1d2;ininlikviedr: +5, +33; 0, +13; _+10, +35. S. Kitaoka relEaxs&timntastiionnmaannd. coWm.pSarniispoenro(fVhiicsttoarmiainInefriermleaarsye,bGylmasugsocwle, cocSaiginneif,iceatcn.c,eonofblospoidnaplrecsosurdre.forButhnezabacutrioonNuokfi,cWaffaetianreu, Sarcionte.)(.I),Bdriiml. eJth. yAltnuebsothceusriaarin2e4,(I2I3)2, -g7a(1ll9am52i)n.e--tdri-eTtuhbioodciudre- KFoaliidaaP, haanrdmaHcoild.eJoapNoonz.u4h7a,raNo(K. y2u, s6h6u-7(U1n95iv1.),.--FuCkauffoekinae)., e(HquIi)v, .anidn dmecuasmclecthroenlaixuimngiodpiodteen(cIVy,), waterceonicnnjesc. tseadid itnotrbae" "craobcbaiintse., anTdhemyolropshtinteheraiascetdiobnlowodhepnretshseursepoinfadleccoarpditawteads , dsuemrmedallytoinatroisheufmroamn shuibsjteacmtsi.neTrheeleaasree,a owfatshecowmhpeaarle, dprien dtheesitrroaycetdio,nsw. hilCeocpaiitnueitriinnj,ectBeadCilnj,traasnpdindalilgyita(lciesrvriectaali)neind IeaacnhdcaIIsewwerietheqthuaatllycapuosetednbt yinaccaounsitnroglshinisjteacmtiionne orfeleHajsOe.. Ill was 75% and IV about 50% as potent as I. C. D. J. i rnaoirsmedal itr._abbPietsrcnaroatianbelydildowneoretdshbolowodthpirsesdseulraeyeadndeflfaetcetr. Caffeine increased pulsation of decapitated rabbits; after essTehnetiabllaocikl-rooftttehne sbwleaectk-proottateton, swne. etTpooxtiactoa.ctioHniroofyathsue dsoemsteruccatsieosn, tohfethpeulsspaitnioanl cdoercdretahseede.ffect was reSdu. cKeidtaaonkda in WJ. aAtagnra.bCehaenmd. HSoisca.yJoashpianIw2a6t,a 1(K80y-u3s(h1u95U2)n;ivc.,f.FuCk.uAo. k4a6),. - -ThPehainrmfluaecnocloegoicnalthestbuldoyod opfictDurige.itarYiaoshisiechKaeamjimumot.o anHd. 9in20g3rAo.w--tRh awtsh(e0n0-t7h0egy. breocdeyivwedt.)owrearlleyno0t.a0f1f-e0c.t0ed2 ngo.tiocefatbhlye essential oil (I), prepd. from the black-rotten sweet potato PKhaaicrmhiarcoolH. aJraapdoan.(T4o7k,usNhiom. a2,U8n1iv(1.95M1e).d--. DC.olils.)c.haeFmoulima has been reported to have desirable therapeutic effects on afesctfeodrmreemrlyarrkeapbolyrtewdi,thpe0r.0d2a-y0.0fo3rg2.0I.daOysr.al aTdhmeyiniwsterraetiaofn- ' eptact.i)entosf tshuebjaetc.tebdomtob airtraHdiiraotisohnims a(xi-nra1y9,45y.-raIyt,wnaesuetrxotdn., ooff 00..010-705.2-0g.0. 1I0tog.rIatisnt(o12m0i-c1e5(020g.g).)anwderaebfdaotamliwnailthiinnje2c7t-io4n2 twoitghivewMateeOr Hat-so8l0.prfiosrm2s (hI)r.s. Ranabdbittrseairtreaddiwatietdh wPibth(OxA-rca)yj hfarstt.yanddeg2e4n-e4r8athiorns.,orfeslipv.er,Ohneamuotorrphsaygebootfh lvuincgti,mrsetsrhoogwreesd - .f(ovrol2ta0gme i1n5.3wkevre., osebcsoernvdeadryfocrucrrheanntg3esmina.,bldoiosdtanpcicetu2r6ecamn.d) snievyes,cahnadngsetoomfachhe.artF, oawnlds lionsjtutrhyeiorfapsmpeatlilteinwtehsetnin0e.,2 kgi.dI abfotdeyr 3wwt.eeokfsIw. erIe iinnjcercetaesdedintthraevelenuocuosclyytewintho.0t.1o74mgax./.k,g2. pexepreklgle.db.odDy owsta.gweaosfgi0v.e3n,ga. nId/dsaoymewpaasrahsaitremslienssthteomawdeurlet c ttihmenesdaescrmeauscehd aist btoefothree tohreigiirnraadl inaoti.onin, a1t wtheeek5.thTdhaey paenrd 0h.u1mga.nsI./daIyn tfhoer u1r0indeayosf,adthuelrterawbabsitsobosrearlvlyedad1m.3i-nfoisldteriend cfuerntthaegredeocfrelyasmepdhboycythteesI dinejcercetaisoend, wbhyilethtehaitrroafdtihaetiposneuwdoas cbroedaisees;ofcrceraetianteiniinncer,eaasnedd r1e.m5-a3r.k0a-fbollydfoinrctrheeasfeirsotf2a-3cedtoanyes epoigsimnoepnht ialendletuhceoecryytethsrowcaysteinncore.awseedreaabffreucptteldy.sligThhtelybblyooId. cforellaosweded; buyregardadiduanlodtecchreaansgee; inglaumcutr.,onaincdanciedithsleirghptrloyteiinn-~ nor indican was found. III. Chemical properties of ipo- The colored compound excreted in saSn.toKniinto-aukriane. Yoshito Kobayashi and Takeo Bando (Univ. Tokyo). mIbeida.ma2r0o0n-e2..--HTihreoyasesumiWcarabtaanzoanbee aonfdthSeadmaoainNisfhraiycatimona., b 127-8, of the crude I was decoinpd. with 5% oxalic acid t uFroilniae-Pobhtaarimneadcowl. iJthaipnon5.h4r8s., aNfote.r3g,i2v1in3g-104.1(1g9.5s2a)n.--toHniunmwaans colored red by adding 5% KOH and it was fractionated. tIo. g4i8v3e1pu[ar]eifi,p2o1m.6ea.maIrIonwcas(IrIe),duCcueHd ncOataa,lydtlica1ll.y02i6n0,Ac1OH soln. to form hexahydro-II(III), and in EtOH soln. to form iNnotenresliatytiownasbeftowuenedn. the effect on Ascaris andS.thKeitcooalokraing The influence of irgapyrin on water retention and carbo gteatvreahnyodrroea-IcIti(oInVs);ofIaIlIe.gabvuet tthheosreeaocftikoentsonoef.aleT.,hewsheiliendIVi cated the presence of 2 C:C groups and 1 CO group in II. hsuyrdiraa)t.e mHe. taKb.olvi.smRe(cihrgeanpbyerrign-(eKdaenmtoanasnspditiarlgsa,pSyrt.inG-gallulceon-, Switz.). Klin. Wochschr. 29, 726-30(1951).--The litera IOIC, IHIIjO, a, nadndIVthgeavdeettnh.eorfeapchtlioornogolfuacimdeetphryoldeunceeddiobxyy gwraorump-, ing II at 80 with 1% phloroglucine in 19% HC1 soln. indi i rtuevreiewonedth. e Ophfatrhmeascioddeyenfafemctisc oafctpioynraozfolpeydraezroivles.c, otmhepdasn.tiis diuretic and the glucosuric effects under irgapyrin (Geigy) ccaartebdazothlee (pcrfe.sVenocteocoefk oanned OVCesHcl:v0,. C.I.I4.di1d, 1n2o8t7r),eathctusweitxh cluding the possibility of having OCH;0 attached to singly (pIaPti)enmtsedoicuattioofn4w50eretregaitveedn wspitehciaIlP ceoxntseindseirvaetioend.emaInw2a0s observed, and in 5 cases glucosufia without hyperglucemia. rbionugn,ditCwaotuolmd s.formIf aOcCriHdiinOe w(cefr.e Fartetaucdheendbetrog, aCb.Aen.ze3n3,e31439), but the expt. gave a neg. result. From these data, uEnxdaemrnI.Posfim12ilaprertsoonthsasthporwoedducaedclbeayr idtsiutrwetoiccoremtaprodnaetniotsn, 4-dimethylamino-l,5-dimethyl-2-phenyl-3-pyrazolone and ItaIinmsusOt ChIaIvOe .2 rings other tSh.anKabwenazmenuera, oannedofI.wUhircihtancion 4sp-b. ugtyr.l-lo,2f -tdhiephuerninyle-3i,n5c-rpeyarsaezdolaidppinreedciiaobnley sfooldliouwmin.g inTtrhae (TTohtteorhiyUpnn2oivti.c).actFioonliaofPhaanrtimhaisctoalm. Jinaipcos.n. K47iv, oNsloii. T2,an3a0k-2a 6 svleignhotulsy.injeTchtiisonefoffecItPi,swshimerielaars,toin tthhaetcoofnthryolpsoiptitdueictareriassmed. d(m1ei9vc5ee1l,o)ap.--nmdBecnehtn.iladdrIrenynl;rhaatbhrbdisiltyssusaghgohewyssptsnhaoytpciclnoosateicctrieoalcnattiiaoopnnpiwenairtrshabbwbrihatiesn,n-- .Gt3ialhulrcsdo.isfiefmedrmeonsecadegiaetisenlaynthdfeotllhcoeuwrdvineegtnfto.hleolofiw'bPeldoinojfder-ocstmuiognar.hgvaatavleoufensothdeeusrsuiennng abprapilnie.d Bdiyreocrtldyintaorythienjselceteipoinnsgtcheentoetrheorr pitasrtvsicoifnitthye ibnrathine ctroematpedds.coinstrtohlr.ouIgthisthsueggmeisdtebdratihnatanthde tahcutisonpaorfalpleylrsaztohlee atipopnesasruptoprbeses etxhcaitteodf stihmeusllteaenpeionugslcyenstoer.thaItnjoetchteiornesxacfittear administration of urethan produce further hypnosis in rah- A msoonTdeoe.xioc4fo2laorcgetyfieo. rnenLocafewsa.rdernecneocTo.rtFicaoiErtrhloeapallnico(rYhGoalrremunoUwnneailvda.n).Kd ucAhonnrnti. bitTs.he influence of cocaine and nicotine on the tiSs.suKeitroeaskpaira rReifme.renMceedt.o 3th, e2t6o5x-i8c2o(lo1g9y52o).f--aArsinree,viBewe, Cwdit,hF,paGrtai,cuPlbar, tainodn oYfuctoackaainKizuedroagnodehniic(oNtianriazeMd eadn.imCaollsl..).IwFaooliYaaPmhaamrmoato- _ mHget,haangeesn,e,amrainreo eaanrdthns,itrSoi,Casdbeersitvoss.,, sCileiHcoen, ehs,alCogSei,naatnedd cWnla. rJbauprgonm. a4n7o, mNeot.er2,thPerocch.an5g0e-s1((1%95)1o).f--tiAsssudeerteds.pibryatitohne insCecutriacriidfeosr.m s1u39bsrteafnecreenscferso.m roots of CiTsshaemrepsealoMs pcaKreeeira. dinaiblyra2inccco./rktegx. ibnejtewcetieonn noofrm0.a1l%ancdoccaoicnaci-nHizCeldforarb6b0itdwayitsh, SR.esNea. rPchradIhnasnt.,, CL.uRckonyo,wa)n.d KC.urSr.enVtaSracdi.an(I(nCdeian)tra2l1,Dr1u7g2 saonldn.fowrer1e2:0 --da2y8s, w--h4e1n; g--iv3e3n, in--400.0;05--a4n5d, --0.0517, Min kciodcnaeinve: i (in1g0l5y2)i.m--pTohretanatlkianloimdaeldiicningeredaisenmtsusocflecureralarxeaanrtes bineccraeuasse - 1 5 ,- 3 1 ; - 1 4 .- 3 6 ; -25. -5.3. and in liver: +14. of their neuromuscular blocking effect The curariform