Document wg3w6B7Kv2pN4ZogrpMeykw14

FILE NAME Kent KNT DATE 1955 DOC KNT142 DOCUMENT DESCRIPTION Book Excerpt - Tumors - Pathology PATHOLOGY BY Peter A. Herbut M.D. a Professor of Pathology Jefferson Medical College and Director of Clinical Laboratories Jefferson Medical College Hospital Philadelphia Pennsylvania 1378 Illustrations on 651 Figures and 6 Color Plates Lea & Febiger Philadelphia 1955 150 Tumors Hydrocarbons are important carcinogenic agents in man Contact with tar soot chimney sweeps pitch asphalt crude petroleum shale oil creosote oil paraffin oil lubricating and fuel oils greases anthracene and distillates produces other cancer of the skin Inhalation of tar dust and fumesis said without definite proof to produce carcinoma of the lungin man Contact with tar and inhalation of tarry fumes may be the cause of or at least have some effect on cancer of the lip tongue oral cavity and pharynx Tarry combustion plays a role in cancer of the abdominal skin in Kangri users in Kashmir in Kairo users in Japan in Change users in China andin Chutta users in India last mentioned producing cancer of the hard palate from smoking cigars with lighted ends in the mouth Dhoti cancer of the loin and groin results from friction of soot that accum- ulatesin a loin cloth Betel nut cancer of the oral cavity in India and the Philippines is due to the tobacco present and Khaini cancer of the lower lip in northern India also occurs from tobacco mixed with lime thatis placed between the lip and gum produces spinners cancer Finally contact with mineral oils Aromatic amines consist of azo compounds and aniline dyes While the former have not yet proved to be carcinogenic in man the latter are defin- produce itely known to cancer of the urinary system Carbon tetrachloride is a cause of cirrhosis and indirectly indirectly a cause of cancer in workers exposed to the chemical over prolonged periods Inorganic chemicals are less important as carcinogenic agents in man than are the organic compounds referred to above Arsenic is in a doubtful category Some workers maintain that topical contact with arsenic pro- duces cancer of the skin while others maintain that such a causative rela- tionship has not been proved Used medicinally however there appears to be no doubt thatit can cause both squamous and basal cell carcinoma of the skin By some authors it is also said to cause cancer of the lung Chromium may be a factorin the production of some cancers of the lung for statistics show that pulmonary carcinoma is at least four times as frequent among chromate workers as it is among the general population Cancers of the nasal sinuses and lungs in workersin copper and nickel re- fineries in South Wales andin nickel mines in Sudbury Canada are more prevalent than they are in the general population The asbestos polymer- polymer- ized SiO industry also is said to be attended by an increase of pulmonary carcinoma Dietary disturbances are unequivocal factorsin the production of carci- noma in animals They have as yet however to be proved of definite etiologic significance in man although certain deficiencies do appear to play a contributory role An imbalanced diet in Sweden and Finland shortin green vegetables predisposes to the Plummer syndrome Thisis attended by a hyperkeratosis of the mouth and pharynx and later carcinoma of the nasopharynx Dietary deficienciesin the Bantus an African Negro tribe are attended by cirrhosis and high incidence of carcinoma of the liver In this connection Gillman fed rats the diet consumed by the Bantus and produced both cirrhosis and carcinoma Cancer of the thyroid gland is more prevalent in districts with endemic goiter due to iodine deficiency thanit is in nongoiterous districts The role of hormones in the etiology of cancer is difficult to evaluate precisely but it is probable that hormones represent the most important single factor Itis certain that most deaths are due to cancer of endogenous origin According to Spencer hormonal deficiency may set up internal es environ normal . the list confined formatio prostate briefly e Fibroc menopa in adole produce entiation is an ex may ex hyperpla hyperpla This all prolifera of secret estrogen fact tha of all ma to canc influenc relative testoster to bones in appet the bon demonst medical soft tiss the men cer of th given to tumor pain ga disappea exerted depressi cells of t Estro squamo estrogen therapy amounts On a pi incidenc chronic estrogen Hyper of estrog estrogen period