Document wXJ8R5XNEr0MkmKXrJrVadLB

Unilever Research Colworth/Welwyn Laboratory Unilever Limited Colworth House Telephone Bedford (0234) 55251 Sharnbrook Bedford Telex 82229 Br. Scott Tucker, Monsanto Chemical Company, South Street, St. Louis, Missouri, U.S.A, ' 21st July, 1970. GMT/GW. Pear Scott, I've been writing up the last of my notes on my recent trip to N. America and I have been reminded that I promised to send you a summary of what was said on the P.C.B. topic at the A.C.S./C.I.C. meeting in Toronto. I've listed the various bits of information on an author basis and these are given in the enclosed notes. I am also reminded that Elmer Wheeler promised to send me a copy of the Monsanto work on the acute and chronic toxicity of P.C.B.'s. Could I now have this information, please? . The post-St. Louis part of my trip became steadily more hectic and it took me a couple of weeks to recover from it after getting homej I very much enjoyed the day which I spent in your company and I hope that we can repeat it some day. Best wishes, Yours sincerely, m I f l I * i M fe % t. Geoffrey M. Telling. I ft i && DSW 228205 it I I I % STLCOPCB4053648 Comments on P.C.B's Made at A.C.S/C.I.C.Meeting Toronto - May 1970 22nd July 1970 < 1. Bitman (U.S.D.A. Beltsville Md). Studied estrogenic activity of D.D.T analogues Pound-that P.C.B's containing up to 48$ chlorine showed some estrogenic activity. 2. Enos (Perrine Primate Research Lab). Studied the use of U.V . irradiation at 2537 A 0 as a means of confirming G.L.C findings, i.e. G.L.C. measurements before and after irradiation. Solutions of P.C.B's in iso-octane were irradiated at 2537A for 20-30 min then examined by G.L.C. No peaks given. Enos suggested that P.C.B's had been destroyed but in fact this ev idence only indicates that the compounds are no longer capable of being gas chromatographed. Probable mechanism is one of free radical formation + polymerisation. 3. Lincoln Reynolds ' (a). Against nitration as a means of separating D.D.E and P.C.B's. (b). Uses a technique based on clean up on a florisil column plus elution with hexane. Cannot separate P.C.B's from D.D.E, aldrin and heptqchlor. (c). P.C.B. pattern in wildlife samples rather more like Aroclor 1260 than Aroclor 1254. (d). Uses a G.L.C system of QP1/SE30 on Chromasorb W and obtains 14 peaks for Aroclor 1254. (e). Semi quantitative method based on comparing areas of peaks 8<gP10 in standard and sample. 4. Biros(Perrine Primate Research Lab) Discussed use of G.C.M.S in residue analysis. Reported that Aroclor 1260 contains the decachloro ion. 5. Grant (F.D.D.Ottawa) Discussed 6OC0 gamma irradiation of P.C.B's Aroclor 1254 gave a 9 peak mixture with his G.L.C. system. After irradiation peaks 1-3 had increased while peaks 4-9 decreased. Pinal peak area was 75$ of original. I ? i iI ifef-- i r G.M.Telling. gmt/jmw. V DSVJ 228206 i STLCOPCB4053649