Document wKgX8J3yBKm0K8qxKLr2na8OJ

EFIDEMX0LGG1CAL STUDY OF VINYL CHLORIDE WORKERS Final Report May 3, 1974 Submitted to The Manufacturing Chemists Association 1825 Connecticut Avenue K.- W. Washington, D. C. 20009 by Tabershaw/Cooper Associates, Inc. 2180 Mllvla Street Berkeley, California 94704 PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" EXHIBIT 1 UCC 079996 ACKNOWLEDGMENT Th research which forms the basis for chis reporc was supported by the voluntary contributions of the following nased chemical companies engager! In the synthesis and/or the polymerization of vinyl chloride, and administered in their behalf by the Manufacturing Chemists Association Air Products and Chemicals, Inc. Allied Chemical Corporation Borden Chemical Division of Borden, Inc. Continental Oil Company * Diamond Shamrock Company The Dow Chemical Company Ethyl Corporation Exxon Chemical Company Firestone Plastics Company B. F. Goodrich Chemical Company The Goodyear Tire and Rubber Company Monsanto Company Olin Corporation PPG Industries, Inc. Shell Chemical Company Stauffer Chemical Company Tenneco Chemicals, Inc. Union Carbide Corporation UNIROYAL, Inc. PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 079997 TABLE OF CONTENTS SECTION * I. Summary II. Introduction III. Selection of Study Plants IV. Data Collection V. The Measurement of Exposure VI. Follow-up of Study Population VII. Description of Study Population VIII. Calculation of Risk of Death IX. Analysis X. Discussion XI. Possible Biases in the Calculation of Risk Page 1 2 3 4 5 6,, 7 9 11 13 15 REFERENCES 17 LIST OF TABLES 1. Follow-up Status of 8384 Vinyl Chloride Workers 2. Distribution of Months in Exposed Employment by Birth Year, for 7128 Vinyl Chloride Workers with Completed Folloy-up 3. Distribution of Months in Exposed Employment by Year in Which Exposure Began, for 7128 Vinyl Chloride Workers with Completed Follow-up A. Distribution by Months of Exposed Employment and Time Weighted Average Exposure Score, for 7128 Vinyl Chloride Workers with Complete Follow-up 5. Person Years of Observation by Year of Birth and Age for Vinyl Chloride Workers 6. Observed Deaths/Expected Deaths and Standardized Mortality Ratios in Vinyl Chloride Workers PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 079998 7. Observed Deaths/Expected Deaths and Standardized Mortality Ratios In Vinyl Chloride Workers, by Estimated Level of Exposure 8. Observed Deaths/Expected Deaths and Standardized Mortality Ratios in Vinyl Chloride Workers by Duration of Exposed Employment 9. Observed Deaths/Expeeted Deaths and Standardized Mortality Ratios In Vinyl Chloride Workers with Exposure Indices below 1.5, by Duration of Exposed Employment 10. Observed Deaths/Expected Deaths and Standardized Mortality Ratios In Vinyl Chloride Workers with Exposure Indices of 1.5 or Greater, by Duration of Exposed Employment ,, 11. Distribution of Deathq by Exposure Category and by Whether Cause of Death Was Determined, and Correction Factors Used for SMR Calculations 12. Results of Follow-up in Several Occupational Groups 13. Angiosarcoma Deaths in VCM Epidemiology Study Population 14. Other Malignancies (190-199, I.C.D.) in VCM Epidemiology Study Population 15. Malignant Neoplasms of Buccal Cavity and Pharynx (140-148, I.C.D.) In VCM Epidemiology Study Population FIGURE 1. Flow Chart of Follow-up Procedure ATTACHMENTS A. Plant Contact Form B. Plant Background Form C. Job History Form D. Follow-up Letter PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" Ucc 079999 EPIDEMIOLOGICAL STUDY OF VINYL CIILOKIDF. WORKERS Final Report - May 2, 1974 I. SUMMARY Eight thousand three hundred and eighty four men who had had at least one year of occupational exposure to vinyl chloride before December 31, 1972, were followed In a historical prospective mortality study.. The major findings of the study are: 1. The overall mortality of the study population was approximately 7> percent of what would be expected In a comparable population of U. S. males. 2. No cause of death showed a statistically significant excess over what would be expected In a comparable U. S. male population. 3. No new deaths identified as angiosarcoma of the liver were found. 4. All previously known Angiosarcoma deaths in the study population during the study period were found as part of the routine study procedure. 5. Cancers of the liver (primarily angiosarcoma), respiratory system, brain, and cancers of unknown primary site, as well as lymphosarcoma, occurred more often than expected in <> DC j= Q UJ O 2<<H til QSs-jgof5* o m -l > < "* I- O Z Jijh UJ O oOf *Qo 0. UJ 69 - those members of the study population with the greatest exposure. Even though the excesses were not statistically significant, the findings warrant further study. 6. Other cancers occurred at lower levels than In the general male population, with the exception of cancers of the buccal cavity and pharynx. There was an excess of these UCC 080000 -2- cancers, which however was Inversely related to exposure. The explanation for this finding Is not apparent. II. INTRODUCTION The study was begun by Tabershaw/Cooper, Associates, Inc. on June 15, 1973, under contract from the Manufacturing Chemists Association. The original eight month period of the contract was later extended by two months. In consideration of logistical problems arising from the number of plants which participated In the study. The objectives of the study are: (1) To compare the mortality of Individuals who have worked in vinyl chloride plants with that of the general population; (2) To compare mortality patterns within the population of vinyl chloride workers, based upon estimated occupational exposure; and (3) To compare mortality among vinyl chloride workers with the mor tality of other groups which TCA, Inc. has studied. The study took the form of a historical prospective mortality study. The study population consisted of Individuals who had worked for at least one year in a job involving exposure to vinyl chloride before December 31, 1972, and Included retired and terminated as well as active workers. For each such worker the date of birth and an employment history were obtained, and the vital status of the worker as of December 31, 1972, was ascertained. For those found to have died, those death certificates that were available were obtained and the cause of death determined. The observed mortality was compared with that of the United States male population. PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 080001 3- III. SELECTION OF STUDY PLANTS The Manufacturing Chemists Association Identified 43 United States plants belonging'to 19 companies, which either produced vinyl chloride r used It In the production of polyvinyl chloride. The name and address of a responsible liaison person at each company and plant was provided to TCA, Inc. (Attachment A). A brief questionnaire was sent to each plant to obtain an estimate of the exposed population and to find out how far back In time personnel records could be obtained, and'to determine whether job histories were available for retired and terminated workers (Attachment B). All the plants responded. On the basis of the replies, four plants were dropped from the study because they had begun operation after 1968. It was felt that exposures in such plants would be too recent and too brief to provide useful data. Study of one other plant was deferred be cause it had stopped production of vinyl chloride seven years ago, and appeared to present difficulties in identifying an exposed population. In addition, three more plants were excluded from analysis because, when data analysis began, it was found that information from these plants was defective in one of several respects (e.g., no exposure data, no job histories available for terminated employees, etc.). The present report therefore deals with 35 domestic plants involved In either VCM or PVC production, which provided a study population of 8384 individuals. "conhdentwlmT0 subject to Pfio4TER"- oroerTective VCC 080002 -ti- IV. DATA COLLECTION ln each plant, data were collected for each worker stated by the -plant management to have been employed for at least one year In o Job Involving exposure to vinyl chloride. In some plants, particularly those producing the monomer, this determination could be made on the basis of job titles. Usually, however, exposure was a function of both job title and the location of the job In the plant, so that the assessment of exposure had to be made on a casc-by-case basis by plant officials. Data were collected for as far back In time as complete records were . kept. In most cases this covered the entire history of the plant. In others, records were kept for a fixed period such as a decade. In a few, records were kept for different periods, depending on whether the worker had died on the job or had left employment. In the latter case it was necessary to exercise care in defining the period for which study data were to be collected. For example, if a plant kept records for five years on those who left employment, but kept them indefinitely for those who died on the job, no termination could be in cluded in the study unless it occurred within the last five years. Data from the earlier period would be biased for the purpose of this study, since a worker had to die to be in the records for the earlier period. The policy therefore was to determine how long each kind of record was kept (quit, discharged, retired and alive, retired and deceased, died while employed) and to define the study period as the shortest of these. One problem which arose In the PVC plants resulted from the fact that a worker could transfer within the plant from exposed to non-exposed jobs. Therefore, even though the number of workers in exposed jobs at a given PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 080003 time may have been a snail proportion of the total work force. It war necessary to search every worker's record to find those who might In th past have had over a year's experience In exposed jobs. Several of the PVC plants undertook to conduct this search themselves. As a result, plant data were collected in two ways. In some plants, a TCA, Inc., team visited the establishment, copied the records designated by management as representing exposed workers, and obtained sufficiently detailed exposure estimates to produce a job history. In others, the % plants were provided by TCA, Inc. with standard forms which they filled out for workers whom they identified as exposed. Three basic forms were used, depending on whether the worker was known to be alive, known to be dead, or was of unknown status. In all three cases a work history with estimated exposure was recorded, the differences being in the ancillary data required. Attachment C shows such a form for workers known to be dead. Approximately 5000 of the study population came from plants visited by TCA, Inc., while the remainder came from plants which had filled cut the forms themselves. V. THE MEASUREMENT OF EXPOSURE The job history forms (Attachment C) were originally designed in the expectation that vinyl chloride exposure on each job could be quantified In parts per million. This proved generally to be impossible. However, industrial hygiene and safety personnel in each plant were able to Identity certain jobs and locations as involving the highest exposures in the plant, arid to classify other exposures as medium or low relative to the "high" represented by the jobs with the greatest exposure. Therefore, the attempt PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 080004 -6- to obtain objective exposure data was abandoned, and each exposed job In the worker's history was scored 1, 2, or 3 to indicate low, medium or high estimated exposure. This gross classification has two major fallings, as a result of the subjective nature of the estimates. The first is that the scores represent estimated relative exposure within a given plant. It is therefore possible that, in objective terms, a "high" score in one plant corresponds to a 'hnedium" or even "low" score in another. The second is that exposures in most plants have tended to decrease over time, so that a worker with long service may have had Jobs in the remote past which involved "low" exposure relative to other jobs at that time, but which might be "high" in comparison with current exposures in the same job. This subjective classification is therefore of questionable validity in characterizing the exposure of a given worker. For epidemiological purposes, however, those who have high scores can reasonably be expected, on the average, to have had the greatest exposure, while those with low scores will have had the least, even though the true exposure in each group may vary considerably from person to person. The estimated exposure history of each worker was summarized by calculat ing An Exposure Index (El) . This was done by multiplying the number of months on each job by the exposure score, totalling these overall exposed jobs, and dividing by the total number of months of exposure. VI* follow-up OF STUDY POPULATION A follow-up procedure was instituted for those who had left employment and whose vital status could not be determined at the local plant. A portion of the terminations was traced by mall, using a form letter sent to the last PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 080005 known address. Attachment D shows such a letter. If the letter was re turned as undeliverable, the procedure shown In Figure 1 was used to obtain a current address. The remainder of the terminations was traced through a retail credit bureau. The latter was also done for a portion of those wbo could not be found by the mall follow-up. ' Approximately 5500 of the study population came from plants In which direct mall follow up was employed. In the remainder of the population follow-ups was by retail credit bureau. There was no significant difference between the success rates of the two methodologies. Table 1 shows the vital status of the study population as of December 3.1, 1972. Follow-up Is 85 percent complete, although follew-up data were still being received at the time the files were closed for this report. Of the 352 workers known to be dead, death certificates have been received for all but 24. The mortality calculations in the succeeding sections of this report are based only on those workers who were successfully traced, which Is equivalent to assuming that mortality among those not found Is the same as among those who were found. In order to examine the reasonableness of this assumption, the differences between those found and not found are examined briefly as part of the following section. VII. DESCRIPTION OF STUDY POPULATION Table 2 shows the distribution of those successfully tTaced, by year of birth and number of months of exposure. The median birth year was 1931 (compared with 1920 for those not found) and the median duration of employ ment In an exposed Job was 80 months (44 months In those not found). The PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" ucc 080006 -8- shortest exposures occur In both the ldest men, most f vhoseworking life was over when vinyl chloride came into general use, and the youngest men, whose date of hire was closer to the closing date of the study. Although nearly half of the study population had less than 60 months of exposed employment, there were nevertheless 855 workers with 20 years or more exposure, and 1641 with 15 years or more. Table 3 shows the distribution by duration of exposure and the year in which exposure began. The median year in which exposure began was 1962 * (versus 1953 for those not found). Notice that almost half the study population first entered exposed employment in the decade 1960-69. This reflects the fact that a great many plants first began vinyl chloride operations in that decade and means that these workers have not been followed for any substantial length of time after their exposure occurred. Table 4 shows the relationship between duration of exposure and Exposure Index (El). The median El is 1.44 (1.75 for those not found). There does not appear to be a close relationship between the EZ and the duration of exposure, that is, workers with a higher FI do not differ substantially in duration of exposure from those with a lower El. One implication is that in assessing the relationship between mortality and exposure, both duration and level of exposure should be examined separate ly, as well as in combination. The data shown above for those not found indicates that they were born (and began their exposure) about 10 years before the group on which follow-up was complete, and had about half the duration of employment with a slightly higher El. Typically, their employment in an exposed job ended before 1960. The bulk of these workers came from older plants from PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 080007 9- whlch data were collected late in the study. Although there appears to be nothing very unusual about this group In terms of work history and exposure. It Is nevertheless true that their exposures took place further back In time than that of the group success fully traced. It is therefore possible that their mortality, after a substantial latent period, might show a somewhat different pattern of mortality from the traced group. VIII. CALCULATION OF RISK OF .DEATH The usual method of describing the risk of death In a study of this kind is to express the number of deaths which actually occurred as a percentage of the number which would have been expected in a comparable male population observed over the same age and time Intervals. This statistic is called the Standardized Mortality Ratio (SMR). In order to calculate the number of expected deaths it is first necessary to calculate the number of years for which each worker was observed, and to classify these years of observation by the age intervals into which they fell and the birth date of the worker. Table 5 shows such a calculation for the 7128 vinyl chloride workers on whom follow-up was complete. This group represents 77,846 person-years of observation. For example, the table shows that for workers born in the years 1925-29, there were 2725 person-years of observation in the age Interval 30-34, and an easy calculation 6hovs that these person-years were lived in a period whose midpoint was about 1960. Therefore, the number of deaths to be expected in this cell of the table is the number of deaths occurring in 1960 among 2725 males aged 30-34 in a comparable non-exposed population. PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE UCC 080008 -10- In the present study the U. S. male population vas used as the standard of comparison, and the age-specific U. S. male death rates for the appropriate ages and years were applied to the corresponding cells of Table 5 to obtain the expected deaths.* This was done for all causes of death together, and for each of the 35 causes for which detailed mortality rates are published oh a national basis (omitting such causes as breast cancer, congenital malformations, and diseases of infancy). Table 6 shows observed and expected deaths, and the SMR, for each % of these causes for the total study group. In calculating the SMR's for specific causes, the 24 deaths for which no certificates were found were assumed to have the same cause distribution as those for which certificates were available. In the standard population, each SMR would be equal to 100. Therefore, the statistical significance of the deviation of each SMR in the study population from the expected value of 100 was tested. A single asterisk indicates those SMR's which differed significantly from 100 at the 5 percent level, that is, which had a probability of .05 or less of occurring by chance. A double asterisk indicates those which were significant at the 1 percent level. SMR's based on fewer than 5 observed 2 cases were not tested for significance. The practical interpretation of these statistical statements will be examined below. d UJ <> 0C p Q UJ O 2 t UJ < S Jr 3o jS Ko q= : uoj <t-o- 9 d 2 I- > 9W pI- Each diagonal in Table 5 corresponds to experience centered around a given year. For the first three diagonals (from left to right) 1950 rates were used; for the next three, 1955, 1959 and 1965 rates were used; for the last two, 1967 rates were used. o" Large-sample tests of significance were derived from: Chlang, C. L., "Standard error of the age-adjusted death rate," Vital Statistics Special Reports, 47 (1961) pp 275-285, UCC 080009 -11- Table 7 shows the sane SNR's for workers with an Exposure Index below 1.5 versus chose at 1.5 or above. The dividing point of 1.5 represents a level halfway between "low" and "medium." Table 8 shows similar results for workers with less than 5 years exposure versus those with 5 years or more. In order to examine the possible Interaction between duration and. level of exposure, the study population was divided into 4 groups on the basis of both El (low vs high) and duration of exposure (short vs long) using the sane dichotomlzatlon as Tables 7 and 8. Table 9 shows the results for short versus long exposure in the low El group, and Table 10 shows the same comparison in the high EX group. In each of the above tables, deaths for which certificates had not been received were assumed to be distributed as a uniform percentage of all causes. The cause specific SMR's were therefore adjusted upward by a percentage which varied in each subgroup. Table IX shows the distri bution of uncertified deaths in each group, and .the resulting percentage by which the cause specific SMR's were increased, IX. ANALYSIS The overall mortality of the study population is statistically significantly lover than that of the U. 5. male population. There were 352 observed deaths compared with 467 expected, for an SMR of 75. Table 6shows that no specific cause of death was statistically signi ficantly greater than expected. Several, particularly heart disease, accidents and "other diseases" not detailed in the tables, were significantly below their expected values. PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 080010 -12- Vhen the study population Is divided according to length and duratl n of exposure (Tables 7 and 8) and combinations of these measurements (Tables 9 and 10) three major patterns emerge. For malignant neoplasms as a whole, the SMR Increases with Increasing exposure, whether measured by level, duration, or both. In the high ex posure group with 5 years or more exposure (Table 10) there are 36 observed cases and 26.11 expected. For cardiovascular - rena*l diseases as a group, there are also Increases In the SMR with increasing exposure, but the number of observed cases remain less than expected, the differences being statistically significant In all groups except the high exposure, long duration group in Table 11. For all other causes, there are no consistent relationships with exposure. Within the malignant neoplasms, the largest (although not statistically) significant SMR is in cancers of the buccal cavity and pharynx, with 5 observed, 2.84 expected, and an SMR of 189. However, Tables 7 to 10 show that all these cases have Exposure Indexes below 1.5, and 4 out of the 5 have less than 5 years exposure. Cancer of the digestive system shows no excess in the study population as a whole. However, in those workers with Exposure Indexes of 1.5 or higher, there are 12 observed cases where 9.14 are expected (table 7). In the subgroup of the above workers with 5 years or more exposure, there are 11 observed cases and 7.47 expected. Respiratory cancer shows a slight excess in the total group, and a similar pattern for different exposure categories, with 13 observed versus 10.28 expected when the Exposure Index Is 1.5 or higher, and 12 observed versus 8.50 expected when, in addition, the duration of exposure is 5 years PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 080011 13- or more. Kallgnant neoplasms of other and unspecified sites show an excess in the total group, and an Increase with both level and duration of exposure (Tables 7 and 8). The relationship with exposure is more pronounced, since those with exposures of less than 5 years have fewer cases than expected. The lymphosarcomas, although occurring at about the expected, rate when the whole group is considered, are concentrated almost entirely in the high exposure long duration group. In that category there,are 4 cases observed % and 1.64 expected. Cancers of the genital and urinary organs, and leukemia, have fewer cases than expected. The number of cases is too small to examine any trends.' X. DISCUSSION The favorable overall mortality of the study population is a phenomenon commonly observed in working populations. Studies of several occupational groups have shown that, even if there is an occupational hazard which greatly Increases the risk of death from a particular cause, the overall mortality may well be favorable. Table 12 shows the SMR's obtained in a number of recent studies of other occupational groups. Although for technical reasons these SMR's are not strictly comparable, the overall mortality in the present study is clearly favorable. SMR's which are higher than expected may be worthy of attention even if they are not statistically significant. This is especially true in the present study since the number of deaths from many causes is quite small, and even a relatively high SHR may not reach statistical significance. If, in addition, a particular cause shows a consistent pattern of Increase with exposure or estimated exposure, the findings are particularly PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 080012 -15- i unknown. About 40 percent of the observed deaths were due t brain cancer. In the general male population, about 22 percent of this category is due t brain cancer, so that not only is the mortality from this cause excessive, but brain cancer is overrepresented. The possibility exists based on the lack of specificity of some of the listed causes that some of the brain cancers were not primary, but metastases from another unidentified site such as the lung. The cancers of the buccal cavity and pharynx are difficult to explain % because of their occurrence in the low exposure - short exposure group. It is possible that this is a chance occurrence, or that exposures to other substances were involved. XI. POSSIBLE BIASES IN THE CALCULATION OF RISK There are three areas in which bias could have entered the calculation of the above SMR's. The first is the choice of the U. S. male population as a standard. The second is the absence of 15 percent of the population who were not found. The third is the discovery, as the study ended, of a group of 1500 workers whose exposures occurred up to 35 years ago, and who are not Included in the study group. The choice of the U. S. male population was not entirely appropriate. -J UJ <> 0 H QlUO zhuJ 2 < t^ SO: D 0C UJ^clUJ o s Jr a U-J*\zz. o 0o > UJ H- SQO QP ui H % CO y co The study population was concentrated almost entirely in the Eastern half of the United States, whose normal mortality is slightly higher than that of the whole country. This implies that the correct expected values should have been slightly higher than the ones which were used, and the corresponding SMR's slightly lower. This has no practical significance except for those malignancies in which the SMR's were above 100. However, regional differences in mortality from those causes is such that these SMR's would have been at Dost 1.5 to 3 percent lower, with no substantive difference In the results. UCC 080014 The workers wh could not be traced-may conceivably c ntaln a dlsprop rtlonate number o deaths, which could Increase the overall SMR. It appears un likely that the distribution of causes would be substantially different. How ever, without actual data In hand, the possibility cannot be ruled out that either some new causes of death might become significant, or that some of the relationships found In this study might be diluted. The same comments apply even more to the group of 1500 workers discovered too late to be Included in the study group, since they would provide data In * precisely the area (very long exposure and long latency) In which the present study Is relatively weak. privileged and "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 080015 References: Archer, VE, Wagoner, JK, Lundin, FE, Jr: Cancer mortality among uranium mill workers. J Occup Med 15:11-14, 1973. Enterline, PE, DeCoufle, P, Henderson, V: Mortality in relation to occupational exposure in the asbestos industry. J Occup Med 14:897-903, 1972. Enterline, PE, Kendrick, MA: Asbestos-dust exposures at various levels and mortality. Arch Environ Health 15:181-186, 1967. Hammond, EC, Selikoff, IJ: Relation of cigarette smoking to risk of death of asbestos-associated disease among Insulation workers In the United States. Symposium on Biological effects of Asbestos, Lyon, October 2-5, 1972, paper #46. Lloyd, JW, Ciocco, A: Long-term mortality study of steelworkers; methodology. J Occup Med 11:229-310, 1969. Lundin, FE, Jr., Lloyd, JW, Smith, EM, Archer, VE, Holaday, DE: Mortality of uranium miners in relation to radiation exposure, hard-rock mining and cigarette smoking--1950 through September 1967. Health Physics 16:571-578, 1969. Redmond, CK, Ciocco, A, Lloyd, JW, Rush, HW: Long-term mortality study of steelworkers--VI. Mortality from Malignant Neoplasms among coke oven workers. J Occup Med 14:621-629, 1972. Tabershaw, IR, Cooper, WC, Balzer, JL: A Labor-management occupational health service in a construction industry. Arch Environ Health 21:784-788, 1970. privileged and "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 080016 Table l Follow-up Status of 8384 Vinyl Chloride Workers Number Percent Total 8384 100.0 Alive 6776 80.8 Dead 352 4.2 Unknown 125b 15.0 Death Certificates Rcc'd. Not Rcc'd. 328 24 92.7 7.3 "CONnog^GEDAND SUBJECT TO PRotJERM1ORosnECTIVE April 15, 1974 UCC 080017 Table 2 Distribution of Months In Exposed Employment by Birth Year, for 7128 Vinyl Chloride Workers with Completed Follow-up Year of birth 1875-79 1880-84 1885-89 1890-94 1895-99 1900-04 1905-09 1910-14 1915-19 1920-24 1925-29 1930-34 1935-39 1940-44 1945-49 1950-54 Total Total 1 5 7 21 38 89 214 404 648 897 940 877 986 1169 700 132 7128 <60 1 l 3 10 9 33 79 145 229 276 287 454 664 632 132 2955 60-119 120-179 Months of exposure 180-239 240-299 300-359 360-419 Unkn>ofwn 22l 33 792 4 9 12 2 13 21 22 17 . 6 27 35 37 43 34 62 58 72 73 43 96 80 120 105 84 191 90 14 3 160 64 214 U8 ' 169 139 20 252 128 181 26 378 120 27 481 16 66 3 15 13 8 1 l 2 2 5 4 4 3 7 8 2 1796 697 786 565 25 39 39 U C C 080018 April 15, 1974 UCC 080019 Tabic 3 Distribution of Months in Exposed Employment by Year in Which Exposure Began, for 7128 Vinyl Chloride Workers with Completed Follow-up Year Exp. Started Total 1930-39 1940-49 1950-59 1960-69 1970-71 35 1048 1962 3368 715 Total 7128 <60 2 135 389 1714 715 2955 60-119 4 93 257 1442 1796 120-179 1 119 383 195 698 Months of Exposure 180-239 240-299 300-359 4 6 13 151 277 237 631 232 * 786 565 250 360-419 5 34 39 Unknown 2 20 17 39 April 15, 1974 \\Vfc V0> cC- \*s *3. o- ^ ^ C> o o tf> UCC 080020 Exposure Index Total l.0-1.4 1.5 + Unknown Total 4032 3057 39 7128 Table 4 Distribution by Months of Exposed Employment and Exposure Index for 7128 Vinyl Chloride Workers with Complete Follow-up Months of exposure <60 60-119 120-179 180-239 240-299 300-359 360-419 Unknown 1715 1240 1125 671 402 295 406 274 380 291 92 159 16 21 39 2955 .1796 497 786 565 251 39 33 May 2, 1974 -<J >UJ q UJ O <5 K Q S. S a: UJ OS UJ 2 tL UJ = Qo O- u-zo. i"nS CQ 9 to UCC 080021 Table 5 Person Years of Observation by Year of Birth and Age for Vinyl Chloride Workers Age Totals Year of Birth 1875 1880 1885 1890 1895 1900 1905 1910 1915 1920 1925 1930 1935 1940 1945 1950 1879 1884 1889 1894 1899 1904 1909 1914 1919 1924 1929 1934 1939 1944 1949 1954 Total 15-19 20-24 25-29 30-34 35-39 40-44 4 5-49 50-54 55-59 60-64 65-69 70-74 75-79 80-84 85-89 77846 134 4070 12076 13861 13550 12031 952 7 6368 3632 1684 632 202 58 16 5 13 92 124 317 705 1662 4055 6710 11038 14305 13807 9408 7239 6174 2023 174 l U 12 5 53 21 31 39 180 5 72 440 475 920 1301 14 3 32 335 1090 18&2 164 2 2173 4221 701 14 264 1054 2183 2725 2863 3778 980 3 221 697 1685 2 742 3688 3 706 808 5 70 524 1028 2044 3 502 4113 745 56 241 710 1226 26 31 384 7 816 35 135 334 762 1574 2768 760 22 88 155 36 3 886 163b 482 14 35 77 142 341 822 253 2 25 31 62 126 270 116 5 23 20 43 71 40 5 15 11 12 15 1 10 5 5 April 15, 1974 "-ftasS? *'BU 6 OBSERVED DEATHS/EXPECTED DEATHS AND STANDARDIZED MORTALITY RATIOS IN VINYL CHLORIDE WORKERS Ctuti of death with I.C.D. number All causes Tuberculosis (001-019) Tuberculosis of respiratory system (001-008) Malignant neoplasms (140-205) Malignant neoplasms, buccal cavity and pharynx (140-140) Malignant neoplasms, digestive organs and peritoneum (150-159) Malignant neoplasms, respiratory system (160-164) Malignant neoplasms, genital organs (170-179) Malignant neoplasms, urinary organs (180-181) Malignant neoplasms, other and unspecified sites (190-199) Leukemia and aleukemia (204) Lymphosarcoma, lymphatic and hematopoietic tissues (200-203, 205) Diabetes mellltus (260) Major cardiovascular and renal diseases (330-334, 400-468, 592-594) Vascular lesions affecting CHS (330-334) Rheumatic fever & chronic rheumatic heart dls. (400-402, 410-416) Arteriosclerotic heart disease (420) tlonrheumatlc endocarditis (421, 422) Hypertensive heart disease (440-443) Other hypertensive disease (444-447) GironIc & unspecified nephritis & renal sclerosis (592-594) Influence and pneumonia (480-493) Ulcer of stomach and duodenum (540,541) Appendicitis (550-553) Hernia and intestinal obstruction (560, 561, 570) Gastritis, duodenitis, enteritis and colitis (543, 571, 572) Cirrhosis of liver (581) llyperplasla of prostate (610) Symptoms, senility and ill-defined conditions (780-795) All other diseases (residual) Motor vehicle accidents (810-835) Other accidents (800-802, 640-962) Suicide (963, 970-979) Homicide (964, 960-985) , Number of workers Person-years lSMR's adjusted lor deaths with cause unknown. *Slgnlftcsnt at SI level. **Slgniflcant at H level. See Table 11. Hay 2. 1974 obs/exp $MRl 352/467.28 75** 1/5.71 1/5.34 79/77.16 5/2.84 19/21.67 25/23.93 3/3.55 1/3.60 17/11.75 3/3.77 6/6.06 7/6.31 155/207.46 13/24.48 5/6.87 121/137.33 1/6.58 3/9.33 3/2.60 0/4.27 5/9.96 2/3.83 0/0.66 1/1.51 1/1.31 3/15.60 0/0.39 1/7.34 21/45.78 17/32.70 18/30.64 16/16.83 1/11.98 19 20 110 189 94 112 91 30 155 85 106 120 80** 57** 78 95 16 35 124 0 54* 56 0 71 82 21 0 15 49** 56** 63** 102 '9 7128 77846 fN <N O O 0o0 U U D <s p QUlO z 5 lu < 5 h~ Q Oc lu -J oc DC O < Q. Ui wPoS =; z f- >UJK 9o a u. uj 2 "> 0m o^ 3 CO :LE 7 OBSERVED DEATHS/EXPECTED DEATHS AND STAND iRDIZED MORTALITY RATIOS IN VINYL CHLORIDE WORKERS, BY ESTIMATED LEVEL OF EXPOSURE Causa of death with I.C.D. number All causes Tuberculosis (001-019) Tuberculosis of respiratory system (001-008) Malignant neoplasms (140-205) Malignant neoplasms, buccal cavity and pharynx (140-148) Malignant neoplasms, digestive organs and peritoneum (150-159) Malignant neoplasms, respiratory system (160-164) Malignant neoplasms, genital organs (170-179) Malignant neoplasms, urinary organs (180-181) Malignant neoplasms, other and unspecified sites (190-199) Leukemia and aleukemia (204) Lymphosarcoma, lymphatic and hematopoietic tissues (200-203, 205) Diabetes mellltus (260) Ms) r cardiovascular and'renal diseases (330-334, 400-468, 592-594) Vascular lesions affecting CHS (330-334) Rheumatic fever & chronic rheumatic heart dls. (400-402, 410-416) Arteriosclerotic heart disease (420) Nonrheumatic endocarditis (421, 422) Hypertensive heart disease (440-443) Other hypertensive disease (444-447) Chronic & unspecified nephritis & renal sclerosis (542-594) Influenza and pneumonia (480-493) Ulcer of stomach and duodenum (S40, 541) Appendicitis (550-553) Hernia and intestinal obstruction (560, 561, 570) Gastritis, duodenitis, enteritis and colitis (543, 571, 572) Clrrh sis of liver (S81) Hyperplasia of prostate (610) Symptoms, senility and ill-defined conditions (780-795) All othey.idiseases (residual) Motor vehicle accidents (810-835) Other accidents (800-802, 840-962) Suicide (963, 970-979) Homicide (964, 980-985) Number of workers Person-years ^SWs adjusted For deaths with cause unknown. "significant at SX level. ""Significant at IX level. See Table ll. May 1, 1974 El <1. 5 obs/exp SMR1 Elfcl. 5 obs/exp SMR1 188/270.33 70** 157/195.68 80** 0/3.38 0/3.16 37/44.28 5/1.62 7/12.50 11/13.56 2/2.30 1/2.07 9/6.57 i/2-je 1/3.48 5/3.65 84/120.11 7/14.42 3/3.98 68/78.94 0/4.20 1/5.48 1/1.52 0/2.50 5/5.80 1/2.21 0/0.39 0/0.88 0/0.76 2/8.90 0/0.25 0/4.22 14/21.90 8/19.08 11/17.83 9/9.73 0/6.98 0 0 90 330 60* 86 93 51 146 49 31 146 75** 52** 80 92 0 19 70 0 92 48 0 0 0 23 0 0 68* 45** 66* 98 0 4032 45354 0/2.33 0/2.18 41/32.67 0/1.21 12/9.14 13/10.28 1/1,43 0/1.52 8/4.52 2/1.57 5/2.54 2/2.65 69/86.99 6/10.06 2/2.85 51/58.05 1/2.89 2/3.86 2/1.07 0/1.77 0/4.13 1/1.60 0/0.27 1/0.63 1/0.55 1/6.64 0/0.14 1/3.09 6/15.89 9/13.46 6/12.67 7/7.02 1/4.94 0 0 134 0 14! 135 75 0 190 136 212 81 85* 64 75 95 38 56 201 0 0 68 0 171 196 16 0 34 41** 72 50** 107 21 3057 32108 en <N oO o00 U U D vv T'ULE 8 OBSERVED DEATHS/EXPECTED DEATHS AND STANDARDIZED MORTALITY RATIOS IN VINYL CHLORIDE WORKERS BY DURATION OF EXPOSED EMPLOYMENT Cause of death with I.C.D. number All causes Tubercul sis (001-019) Tuberculosis of respiratory systea (001-008) Malignant neoplasms (140-205) Malignant neoplasns, buccal cavity and pharynx (140-148) Malignant neoplasns, digestive organs and peritoneun (150-159) Malignant neoplasns, respiratory system (160-164) Malignant neoplasns, genital organs (170-179) Malignant neoplasns, urinary organs (180-181) Malignant neoplasms, other and unspecified sites (190-199) Leukemia and aleukemia (204) Lymphosarcoma, lymphatic and hematopoietic tissues (200-203, 205) Diabetes mellltua (260) Major cardiovascular and renal diseases (330-334, 400-468, 592-594) Vascular lesions affecting CNS (330-334) Rheumatic fever & chronic rheumatic heart dis, (400-402, 410-416) Arteriosclerotic heart disease (420) N nrheumatlc endocarditis (421, 422) Hypertensive heart disease (440-443) Other hypertensive disease (444-447) Chronic & unspecified nephritis & renal sclerosis (592-594) Influenza and pneumonia (480-493) Ulcer f stomach and duodenum (540,541) Appendicitis (550-553) Hernia and intestinal obstruction (560, 561, 570) Custrltls, duodenitis, enteritis and colitis (543, 571, 572) Cirrhosis of liver (581) Hyperplasia of prostate (610) Symptoms, senility and ill-defined conditions (780-795) All othey, diseases (residual) Motor vehicle accidents (810-835) Other accidents (800-802, 840-962) Suicide (963, 970-979) Homicide (964, 980-985) Number of workers Person-years *SMR`s adjusted for deaths vlth cause unknown. *Slgnificant at 5X level. **$igniftcant at 11 level. See Table ll. Hay 2, 1974 <60 months obs/exp SKR1 44/140.53 67** 0/2.23 0/2.07 13/19.96 4/0.70 2/5.26 3/5.52 0/0.99 0/0.83 2/3.40 1/1.25 1/2.01 2/1.80 20/51.45 4/5.97 2/2.39 21732.54 0/1.79 1/2.42 0/0.79 0/1.55 3/2.93 1/1.07 0/0.24 0/0,42 1/0.40 1/4.49 0/0.07 1/2.28 4/11.97 10/16.14 7/12.94 6/6.34 1/5.80 0 0 78 688 46 65 0 0 71 96 60 134 65** 81 101 78* 0 49 0 0 123 112 0 0 301 26 0 53 40 75 65* 114 20 2955 34201 fc60 months obs/axp SI*1 251/329.30 76** 0/3.55 0/3.33 65/57.61 1/2.16 17/16.56 21/18.51 3/2.76 1/2.79 15/8.23 2/2.53 5/4.07 5/4.54 125/157.39 9/18.71 3/4.53 98/105.39 1/5.35 2/7.01 3/1.82 0/2.76 2/7.09 1/2.78 0/0.43 t/1.10 0/0.92 2/11.18 0/0.33 0/5.09 16/26.34 7/16.65 10/r17.82 10/10.28 0/6.20 0 0 116 47 t06 116 112 37 187 81 126 113 81** 49** 68 96 20 30 170 0 29 37 0 93 0 18 0 0 63* 43** 58* 100 0 4134 43240 i -<1 Ul > Q h* QzbUJuOi 2<H ^o SjtcOoS: UJ D. UJ UJl \zZ 2t- cot 2qo ? E UJ O CD O iBLE 9 OBSERVED DEATHS/EXPECTS9 DEATHS /HD STANDARDIZED MORTALITY R.vTIOS IN VINYL CHLORIDE WORKERS WITH EXPOSURE INDICES BELOW 1.5, BY DURATION OF EXPOSED EMPLOYMENT Cause of death with I.C.D. number All causee Tuberculosta (001*019) Tuberculosis of respiratory system (001-008) Malignant neoplasms (140-205) Malignant neoplasms, buccal cavity and pharynx (140-148) Malignant neoplasms, digestive organs and peritoneum (150*159) Malignant neoplasms, respiratory system (160-164) Malignant neoplasms, genital organs (170-179) Malignant neoplasms, urinary organs (180-181) Malignant neoplasms, other and unspecified sites (190-199) Leukemia and aleukemia (204) Lymphosarcoma, lymphatic and hematopoietic tissues (200-203,205) Diabetes mellltus (260) Major cardiovascular and renal diseases (330-334, 400-468, 592-594) Vascular lesions affecting CHS (330-334) Rheumatic fever & chronic rheumatic heart dls. (400-402, 410-416) Arteriosclerotic heart disease (420) N nrheumatic endocarditis (421, 422) Hypertensive heart disease (440-441) Other hypertensive disease (444-447) (Tronic 6 unspecified nephritis & renal sclerosis (592-594) Influenza and pneumonia (480-493) Ulcer of stomach and duodenum (540, 541) Appendicitis (550-553) Hernia and Intestinal obstruction (560, 561, 570) Gastritis, duodenitis, enteritis and colitis (543, 571, 572) Cirrhosis of liver (581) Hyperplasia of prostate (610) Sympfpms, senility and ill-defined conditions (780-795) All other diseases (residual) Motor vdhicle accidents (810-835) Other accidents (800-802, 840-962) Suicide (963, 970-979) Homicide (964, 980-985) Number of workers Person-years *SMR*e adjusted lor deaths with cause unknown. Significant at 51 level. ^Significant at IT level. See table ll. <60 months exposure obs/exp SMR^ obs/exp PSHRl 56/89.23 63** 132/181.28 73** 0/1.41 0/1.31 8/12.86 4/0.45 1/3.43 2/3.58 0/0.68 0/6.55 1/0.97 0/0,79 0/1.26 2/1.15 21/33.38 2/3.93 2/1.50 16/21.14 0/1.18 1/1.58 0/0.50 0/0.97 3/1.86 0/0.68 0/0.15 0/0.27 0/0.26 1/2.80 0/0.05 0/1.43 4/7.45 3/9.87 3/7.98 3/4.08 0/3.55 0 0 73 1036 34 65 0 0 120 0 0 203 73** 59 155 88 0 74 0 0 188 0 0 0 0 42 0 0 63 35 44 86 0 0/1.97 0/1.85 29/31.46 1/1.17 6/9.08 9/10.00 2/1.62 1/1.53 8/4.43 1/1.40 1/2.23 3/2.50 63/86.82 5/10.51 1/2.49 52/57.87 0/3.02 0/3.90 1/1.02 0/1.53 2/3.95 1/1.53 0/0.24 0/0.61 0/0.51 1/6.09 0/0.20 0/2.79 10/12.92 5/9.22 ' 8/9.85 6/5.66 0/3.43 0 0 95 88 60 93 127 67 187 73 46 124 75** 49* 41 93 0 0 101 0 53 67 0 0 0 16 0 0 79 56 83 109 0 1715 21418 2317 23920 z o o00 u U < i>n a: H a uJ O is LU h001 =CC. a. lu og >--a: ^rr o L--U) m May 2, 1974 lAbUS LU OBSERVED DEATHS/EXPECTEO DEATHS i HD STANDARDIZED HORTALm RATIOS 1H VINYL CHLORIDE WORKERS WITH EXPOSURE INDICES OP 1.5 OR GREATER, BY DURATION OP EXPOSED E!IFLOYMENT Cause of death with l.C.D. number All causes Tuberculosis (001-019) Tuberculosis of resporatory system (001-008) Malignant neoplasms (140-205) Malignant neoplasms, buccal cavity and pharynx (140-148) Malignant neoplasms, digestive organs and peritoneum (150-159) Malignant neoplasms, respiratory system (160-164) Malignant neoplasms, genital organs (170-179) Malignant neoplasms, urinary organs (180-181) Malignant neoplasms, other and unspecified sites (190-199) Leukemia and aleukemia (204) Lymphosarcoma, lymphatic and hematopoietic tissues (200-203, 205) Diabetes mellitus (260) Major cardiovascular and renal diseases (330-334, 400-468, 592-594) Vascular lesions affecting CHS (330-334) Rheumatic fever & chronic rheumatic heart dls. (400-402, 410-416) Arteriosclerotic heart disease (420) Nonrheumatic endocarditis (421, 422) Hypertensive heart disease (440-443) Other hypertensive disease (444-447) Chronic & unspecified nephritis & renal sclerosis (592-594) Influenza and pneumonia (480-493) Ulcer of stosMch and duodenum (540, 541) Appendicitis (550-553) Hernia and intestinal obstruction (560, 561, 570) Castrltls, duodenitis, enteritis and colitis (543, 571, 572) Cirrhosis of liver (581) Hyperplasia of prostate (610) Symptoms, senility and ill-defined conditions (780-795) All other diseases (residual) Motor Vehicle accidents (810-835) Other accidents (800-802, 840-962) Suicide (963, 970-979) Homicide (964, 980-985) Number of workers Person-years *SMR*s adjusted for deaths with cause unknown. ^Significant at St level. ^Significant at It level. See Table 11. Hay 2, 1974 <60 months exposure *60 months exposure obs/exp SNR* obs/exp 5HR* 38/47.93 79 119/147.81 81* 0/0.76 0/0.71 5/6.57 0/0.23 1/1.67 1/1.79 0/0.29 0/0.26 1/1.18 1/0.44 1/0*71 0/0.61 7/16.54 2/1.87 0/0.82 5/10.41 0/0.57 0/0.76 0/0.27 0/0.54 0/0.99 1/0.35 0/0.08 0/0.14 1/0.14 0/1.56 0/0.01 1/0.80 0/4.02 7/6.05 4/4.73 3/2.40 1/2.18 0 0 96 0 76 71 0 0 107 288 178 0 54** 135 0 61* 0 0 0 0 0 362 0 0 904 0 0 158 0 146 107 158 58 0/1.57 0/1.48 36/26.11 0/0.99 11/7.47 12/8.50 1/1.41 ' 0/1.26 7/3.51 1/1.13 4/1.84 2/2.04 62/70.46 4/8.19 2/2.04 46/47.65 1/2.32 2/3.10 2/0.81 0/1.23 0/3.13 0/1.25 0/0.19 1/0.49 0/0.41 1/5.08 0/0.13 0/2.30 6/11.88 2/7.43 2/7.96 ' 4/4.62 0/2.76 0 0 141 0 151 144 73 0 204 90 222 100 90 so 100 98 44 66 253 0 0 0 0 209 0 20 0 0 51* 28 26 88 0 1240 12828 1817 19305 O CM Oo 0o0 o U Table 11 Distribution of Deaths by Exposure Category and by Whether Cause of Death Was Determined, and Correction Factors Used for SMR Calculations Total* Exposure Index <1.5 a.s EXDOsurc Categories Total Exposure Exposure Index and Total Exposure Time in Months in Months <60 260 <1-5 , <1.5 *1.5 * 1.5 & <60 & 260 & <60 6 260 All causes 352 168 157 94 251 56 132 38 119 Cause known 328 176 146 78 244 Cause unknown 24 12 ll 16 7 48 128 84 30 116 83 Percent Increase In SMR's 7.3 6.8 7.5 20.5 2.8 16.6 3.1 26.6 2.5 ^Deaths in exposure categories do not add up to deaths in total category because 7 deaths had unknown exposure data, and one of those was of unknown cause. May 2, 1974 <N oO oo o U U UJ <> 00 P Q Ul O zhiu 21 <2 vQ- = , D , (t tt; UouliS7tzQ^P.ol0l11 JZ^O CtoUioH 00 51 Ul o-oz2 9 vi Table 12 Results of Follow-up in Several Occupational Groups " Study Population Number Years of SMR Observed Observation All causes Reference Asbestos building product workers - 12,402 1951-1963 Enterlinc 89 Kendrick, 1967 Asbestos friction material workers 7,510 M Enterline 89 Kendrick, 1967 Asbestos textile plant workers Cotton textile workers 1,843 6,281 m M Enterline 121 Kendrick, 1967 - Enterline 88 Kendrick, 1967 White underground uranium miners 3,414 1950-1967 Lundin et al, 159 1969 Steelworkers 59,072 1953-1961 82 Lloyd & Ciocco, 1969 Asbestos insulation workers > 20 years 250 1946-1965 Tabershaw et al, 140 1970 Coke oven workers 4,661 1951-1966 98 Richmond et al, 1972 Asbestos maintenance service, etc. 438 1941-1969 Enterline et 124 al, 1972 Asbestos insulation workers > 20 years 370 1963-1971 Hammond 198 Selikoff, 1972 Asbestos insulation workers 17,800 1967-1971 Uranium mill workers 662 1950-1967 Lead smelter workers 2,352 1946-1970 Lead battery plant workers 4,680 1946-1970 Petroleum refinery workers 18,916 1962-1971 Hammond 136 Selikoff, 1972 99 Archer et al, 1973 107 TCA, Inc., unpublished 99 TCA, Inc., unpublished 68 TCA, Inc., unpublished May 3, 1974 PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 080028 PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" Table 13 Angiosarcoma Deaths in VCM Epidemiology Study Population Study No. Age at Death 4250 , 54 4255 60 5765 45 7303 38 7376 52 7385 43 Mos. Exposed 203 281 167 174 238 214 Cause as Given Cirrhosis of liver (sev. weeks) Autopsy yes Bleeding from hepatoma (3 days) (Laennecs cirrhosis) yes Angiosarcoma rt. lobe of liver (10 mos.) yes Liver failure (l mo.) Cancer of liver, primary (15 mos.) - Cardiac tamponade and massive left hemothorax (mins.) Widely metastatic angiosarcoma of liver (4 mos.) m Hepatic failure Primary carcinoma liver yes UCC 080029 April 15, 1974 CcO O CD O 0S2 o"*m< 2 --i z r gOHm mi m in z omo H^ <m > r- d o O o 0oo0 u> o Tab*. lb Other Malignancies (190- 199, l.C. 0.) In VCM Epidemiology Study Population Study No. 2744 r 3700 2096 3946 4433 4800 7279 7300 7371 7306 5769 Age at Death 38 48 67 43 54 61 57 44 e 58 53 52 Mo a . Exposed 186 50 69 64 81 51 271 211 249 216 239 Cause as Given Autopsy Widespread metastatic melanoma (1 yr.) Malignant melanoma of back yes Malignant melanoma with widespread metastases no Brain tumor (carcinoma) (8 mos.) a* Meningitis and pneumonitis (5 wks.) Ependymoma, fourth ventricle-brain (2 mos. post-op craniotomy) no Astrocytoma, malignant-left cerebral yes hemisphere (l yr.) Carcinoma of the brain Arteriosclerosis Pneumonia due to static congestion no Brain tumor, glioblastoma multiforme (18 mos.) Brain tumor, malignant (2 mos.) Brain tumor, malignant no Thyroid carcinoma with metastases no Ca reinoma tos 1s Carcinoma vertebral body yes V- 6 CD O m oo H m z < r- go h m m 70 "o 70 > p O H 5O mH o si mo 2 <m > Table l1* Ocher Malignancies (cont.) Study No.' Age at Death 5246 67 2850 64 4778 54 Mos Exposed 201 193 300 Cause as Given Autopsy Liposarcoma with metastasis (3 mos.) yes Carcinomatosis, primary region not known (Past history, rheumatoid arthritis, myocardial infarction) no Cardiac arrest (l hr.) Respiratory arrest and cerebral hypoxLa (2 days) Widespread metastatic carcinoma (2 mos.) 4786 61 318 Generalized metastasis undiffer* yes. cntlated (7 mos.) Squamous cell carcinoma, primary site undetermined 5783 69 166 Metastatic carcinoma of abdomen Critical site undetermined (Pulmonary emphysema) 7301 55 133 Carcinomatosis (4 mos.) Primary site undetermined no d o o 00 April 15, 1974 o u> oCO c 6 CD 5X m2a oog oh m < 2nzr OHm III mdz omo d :*> <m >i- Tab ie 15 Malignant Neoplasms of Buccal Cavity and Pharynx (140-148, I.C.D.) in VCM Epidemiology Study Population Study No. 3003 3431 . 3001 7365 3354 Age at Death 31 56 57 54 63 Mos. Exposed 49 30 71 40 . 26 Cause as Given Autopsy Carcinoma of lip with metastasis to lung and neck (5 yrs.) no Pulmonary edema (50 min.) Pulmonary metastases (Carcinoma, epidermoid, tongue and mandible) no Metastatic squamous cell ca. primary lesion palate yes Atelectasis due to metastasis to mediastinum (4 mos.) Multiple malignant metastases to brain, liver & mediastinum (l yr. ) Adeno-carcinoma of nasal pharynx (2 yrs.) yes Massive hemorrhage Into tracheotree Status post laryngo-pharyngeetomy. Left radial neck dissection Well-differentiated keratinizing squamous cell carcinoma of left pyriform sinus (mos.) yes c n o April 15, 1974 o 00 o u> to Manufacturing c..etrists Association VCM Epiuemioloov Study Parent Corporation Plant Designation Address _________________________________________________ Telephone ( ext. TABERSHAW-COOPER ASSOCIATES* CONTACT FOR SUBJECT STUDY: Name a _____________________________________________________ Title ___________________________________ _________________ Mailing Address_______ ___ Street Address (please identify with sufficient precision to serve as a taxi-driver's instruction) Telephone Signed Name Title Company Address Telephone __ ATTACHMENT A ext. UCC 080034 Tabershnw-Cooper Associates, Inc. 2180 Milvla St., Suite 104 Berkeley, California 94704 Manufacturing Chemists Association VCM Epidemiological Study Plant No. 1. When did this plant begin work involving vinyl chloride? * 2. What is the approximate size of the current work force, exclusive of secretarial and office personnel? 3. Approximately how many of these are employed in Jobs in volving some exposure to vinyl chloride? 4. Please answer the appropriate one of the following questions about your retirement plan. a. No retirement plan b. Voluntary plan, begun in c. Required of all employees, begun in d. Now required, formerly voluntary. Voluntary plan begun in Required plan begun in Remarks: _____________ ____ ________ ______________ PRIVILEGED AND " CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" 5. Please answer the applicable questions below about retention of records. How long are personnel records kept a. for those who retired but were not covered by a retirement plan? b. for those who retired under a retirement plan and have died? c. for those who quit or were discharged? d. for those who died while employed? ATTACHMENT B UCC 080035 Tabershaw-Cooper Associates, Inc. page 2 6. Do the personnel records which are retained contain a record of job titles and dates of job title changes for the individual concerned? 7. Please list the job titles in the current work force which involve sone exposure to vinyl chloride. ATTACHMENT B (cont.) Ucc 080036 VCN Epidemiological Study - Individual Work History Form ft - Workers known to have died (please attach copy of death certificate) 1. Dace of birth 2. Date hired ___ 3. Date of death 4. Place of death Status at time of death: 5. Employed ________________ 6. Retired (give date) __ 7. Terminated (give date) 8. If death certificate Is not available, please give name of worker so that death certificate can be obtained. No contact will be made with relatives or attending physician. PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" Job no. Job history with estimated exposure Title 1 from _____ to 2 from to _________ 3 .______ ____________ from________ to 4 _________________________ from______ __ to _________ 5 from to _________ 8 from to _________ 7 ________ .______________ from ______ _ to Qieck estimated exposure in ppm *50 50-199 200-500 >500 UCC 080037  habershcii.Li. cooper sstjcoles inc 2t0 Milvia Sired. Bcikclcy. California 94704 Telephone (415) 845-3355 Dear We are a research Ttrm concerned with the health of workers in industry in the United States. We have been asked to study certain occupations in order to determine the health of men who have at one time or another worked in these occupations. To accomplish this we n*ed to know if those men we are interested in were alive on December 31, 1972. For any of the men who died on or before that date, we need to know the place and date of death. With these facts, we can compare the health statistics of our men with the general population. To assist us, can you provide information regarding the person whose name appears below? A stamped, addressed return envelope is enclosed for your reply. Needless to say, any information you give us is strictly confidential. Thanks for your cooperation and assistance with this project. Sincerely, lit <> 5H o uj O zb 2; UJ H O LU O -d < oc 0. a: UJ Q oLU > Of o0. z UJ O Ez H o UJ -> m Q O ow Name: Date of birth: Was above named man alive as of 12/31/72? If deceased prior to 12/31/72: Date of death place of death (city and state) ATTArWMVNT n UCC 080038 I hereby certify that the foregoing document is a true, correct and complete copy of the document in my possession. Subscribed and sworn tohefore me this day of Herbei PRIVILEGED AND "CONFIDENTIAL MATERIAL SUBJECT TO PROTECTIVE ORDER" UCC 080039