Document wDo6ekqDBbq37p6LjE4bd65n3

FILE NAME: Chemical Abstracts (CHAB) DATE: 1966 DOC#: CHAB053 OCUM ENT DESCRIPTION: Abstract Originally Published in 1964 by Cochrane tf> *c \ 2 3 0 '1 Petah Tiqva, Israel). Brit. J. Ind. Med. 21(4), 209-303(19(14) esp. Zn. Thus, in spite of their stability consts. in vitro, EDTA (Eng). In the tnanuf. of ZnO from old airplane batteries contg. exhibits a polyvalent action, while desferrioxamine does not. 0.8% Hg as Zn amalgam, Hg vapors were released into a plant These effects may be modified by many biol. factors which may atm. at an estd. level of 0.3-2.0 mg./m.* Severe poisoning de interact and affect gastrointestinal absorption and transporta veloped in 7 out of 25 plant employees, with tremor as the leading tion of metals, and their fixation by proteins and other tissues, symptom, Hg level (in y/\.) of 103-212 in urine, 3.6-9.1 in the 0 and elimination via the kidneys. Also, each reaction has its cerebrospinal fluid of 6 cases, and 82.7 of the 7th case. Initial own kinetics, and the chelating agents have many competitors D-penicillamine treatment was abandoned because of skin reac and arc themselves metabolized in different ways. These tions; BAL was of no apparent benefit. The other workers factors are responsible for the pathol. deposition of a metal with (generally with less exposure) presented mild or no symptoms, resultant functional impairment, and also for elimination of the with 89-360 y Hg/1. urine on 1st examn. Andrew L. Reeves _ metal with therapeutic results, whether in the case of accidental A follow-up study of workers from an asbestos factory. P. C. poisoning or chronic intoxication. The situation differs de Elwood, A. L. Cochrane, I. T. Benjamin, and D. Scys-Prosser. pending on the metal and the chelating agent, and on whether Brit. J. Ind. Med. 21(4), 304-7( 1964)(Eng). Men surviving 1st the metal, endogenous or exogenous, is accumulated slowly or is occupational exposure to chrysotile dust by 15 or more years an acute intoxication. Desferrioxamine is a particularly useful show 2.3 times the expected mortality from pulmonary, bron therapeutic agent for use in mobilizing Fe stores in an organism chial, or pleural neoplasms, but there was only 1 case of meso- b due to its low toxicity and almost exclusive affinity for Fe. thelioma. Andrew L. Reeves EDTA, in comparison, is more toxic and less specific. 39 refer Plasma porphyrins in lead workers. H. A. Waldron (Vaux- ences. A. E. Cameron hall Motors Ltd., Luton, Engl.). Brit. J. Ind. Med. 21(4), The toxicity of beryllium sulfate towards the isolated lung of 315-17(1964)(Eng). In 50 workers exposed to Pb, total por the guinea pig. Pham-Huu Chanh (C.N.R.S., Toulouse, phyrin (I) in plasma averaged 0.7, and coproporphyrins (II) in _ France). Med. Exptl. 11(3), 202-6(1964)(Eng). The lung, urine 10.6 -y/100 ml. (vs. 0.2 and 0.7 in controls); individual "heart, and trachea were removed from the guinea pig. Tyrode correlatability between the 2 values was poor. II comprised all of soln. was perfused through the pulmonary artery, and the heart I in the plasma of controls but some protoporphyrin was present was cut at the apex. The prepn. was placed in an artificial in the exposed group. Urinary I in 4 exposed workers also in thorax, the trachea cannulated, and a mixt. of 95% 0-5% COj cluded compds. having R/ values of 0.65 and 0.33 (in MejCO- supplied to the lung. Neg. pressure in the thorax produced a EtsO-HOAc, 5:5:1), corresponding to porphyrins with 3 and 6 c dilation of the lung and upon redn. of the pressure, lung con carboxyl groups, resp. These values are slightly lower than striction occurred. When a 10-tng. dose of aq. BeSO was ad those of Eriksen ( CA 47, 10603/). Total hemoglobin showed no ministered by pulmonary arterial injection, constriction of the difference, and there were no symptoms of intoxication. alveoli and bronchi occurred. A 1% submicronic aerosol of Andrew L. Reeves BeSO produced the same result. Aerosolized adrenaline or Effect of aminoalkylphosphonic acids on experimental in Effortil neutralized the constrictive effect of Be but did not toxication with beryllium. O. G. Arkhipova, T. A. Kochetkova, --- protect against a later insult. Aerosols of Aerolone (compn. not M. V. Rudomino, T. Ya. Medved, and M. I. Kabachnik (Inst. given) neutralized the constriction and protected the lung Heteroorg. Compds., Moscow). Dokl. Akad. Nauk SSSR against later exposures to Be. W. L. Downs 158(5), 1235-7(1964). Administration by intraperitoneal in Urinary elimination of mercury and the effect of dimercaprol jection of [CHjNHCMe!P(0)(OH)ONa]s (I) at 500 mg./kg. on mercury elimination in chronic occupational poisonings. resulted in survival of nearly all rats after injection of lethal Halina Koziolowa and Teresa Boniecka (Akad. Med., Warsaw). doses of BeClj. Lower concns. gave less protection; Na citrate fl' Med. Pracy 14(2), 139-47(1963). In patients with suspected used in conjunction with I also gave considerable survival values. occupational Hg poisoning, diurnal urine contained up to 600 y Pyridoxine or glucuronic acid, used jointly with I, also gave Hg/1. Highest Hg concn. was observed in the overnight urine. similar results. Anatomically animal organs after Be intoxica Administration of dimercaprol (2.5 mg./kg. at first and later 1 tion showed severe disruption of circulation. These effects are mg./kg., intramuscularly) elevated the Hg level in urine, the largely controlled by I. The enhancement of the action of I by _- peak values being observed after 4-8 hrs. The low dosage of citrate, pyridoxine, or glucuronic acid is possibly explained by the drug proved to be sufficiently effective. Jerzy Lange some hindrance of the union of Be with proteins, making the Sodium-calcium edetate in protective creams for workers ex latter more available for complex formation and eventual ex posed to metal salts. Teresa Kochanowiez (Inst. Med. Pracy, cretion. Stable Be complexes are also formed by (CHjNHCHjP- Zabrze, Poland). Med. Pracy 14(2), 199-204(1963). Creams (OXONa)OH], and (CHjNfCHjCO^CHjPfOXOH):),. No contg. 20% Na Ca edetate (I) gave excellent protection against biol. tests with these are reported. G. M. Kosolapoff <! skin disorders caused by contact with Cr, Co, Mn, Pb, Ni, and Some data on the beryllium level in biological media during Zn salts. Treatment of such disorders was not so effective. I berylliosis. P. A. Rozenberg and A. A. Orlova (Inst. Ind. Hyg. added as a 10% soln. to plating and coating baths (_1:1 by vol.) and Occupational Diseases, Acad. Med. Sci., Moscow). Gigiena markedly increased the pH: in Ni baths, from 2.7 to 4.5; in Truda i Pro}. Zabolevaniya 8(9), 42-6(1964)(Russ). Be concn. Cr baths, from 0.1 to 0.7; and in Zn baths, from 3.3 to 4.7. in 24-hrs.' urine was examd. in patients with chronic berylliosis Jerzy Lange and in healthy persons that had worked with Be for some years. ~" 5-Aminolevulinic acid excretion in lead poisoning. H. Ur- In most cases in both the groups no Be was found, but 2 healthy banowicz, Jan Sroczynski, and B. Piekarski (Inst. Med. Pracy, men excreted 1.77 and 3.16 y/24 hrs. 1 and 3 years after Be Zabrze, Poland). Med. Pracy 14(3), 205-10(1963). Urinary exposition. Be in blood was not proved in any case. Then 40 excretion of 5-aminolevulinic acid (I) was surveyed by the mg. of Be as BeO was administered into rats by intratracheal method of Mauzerall and Granick (C.4 50, 7929r) in 20 cases technique. After 2, 3, and 4 months the rats were killed and , of typical chronic Pb poisoning and in 15 control subjects. In the amt. of Be in the internal organs and blood was examd. the poisoned patients, the threshold value of 0.57 mg. % was The blood Be level decreased and was = 0 in the last group, invariably exceeded, some findings being even as high as 7 mg. %. while the content in liver and kidneys did not considerably In general, I content in urine was indicative r r the poisoning change. Be can be stored in an organism for many years and degree; it showed good correlation with coproporphyrin ex small amts, are excreted with urine periodically. 15 references. cretion and basophile erythrocyte count in the peripheral blood. Ivo Hynie -- Therapy with Na Ca edetate lowered the urine I level in a short Renal function in initial manifestations of chronic lead poison time. Jerzy Lange ing. V. I. Dynnik (Inst. Ind. Hyg. and Occupational Diseases, Effect of orally administered edetic acid upon absorption and Kharkov). Gigiena Truda i Prof. Zabolevaniya 8(9), 57-9 elimination of lead introduced by the same way. D. Brykalski (1964)(Russ); cf. C/t 61, 8810r. The functional state of kid and B. Wronowa (Inst. Med. Pracy, Lodz, Poland). Med. neys and some other' clin. symptoms were followed in 99 cases Pracy 14(4), 313-20(1963). 5'Pb(NOa)j was given to rats of slight chronic Pb poisoning. The av. Pb concns. in blood 11 with food; Na Ca edetate was similarly administered to the and urine were 0.0(1 and 0.2 mg. %. In blood occurred reticulo- animals in 5 50-mg. doses, one 12 hrs. prior to and 4 over the 2 cytosis, polychromasia, and anemia (70-75%), the porphyrin days following the administration of l'b. The animals were urine level was 0.09 mg./I. A decrease of kidney blood-plasma killed 48 hrs. after administration of Pb, and the content of flow (400 ml./min.) and of creatinine clearance and a rise of the tiopb was detd. radiometrically in sep. organs. The drug de- filtered fraction (30%) were observed. Pb probably causes _ creased 210Pb cumulation in liver by 45%, in kidneys by 26%, spasms of the vasa efferentia in kidneys. Ivo Hynie ~ and in bones by 21%, and increased urinary elimination by Pharmacological comparison of the binding of iron and other 500%. The av. absorption of 210Pb was 0.24% in untreated and metals. J. Tripod (CIBA A.-G., Basel, Switz.). Iron Metab., 0.59% in treated animals. _Jerzy Lange Intern. Symp., Aix-en-Provence, France 1963, 503-17, discussion Electrophoretic examination of serum proteins in acute poison 518-24(Pub. 1964). Some data on the action of desferrioxamine ing due to soluble mercury salts. Stanislaw Kosmider and and EDTA were presented. The results showed that Fe onty h Stanislaw Zajaczkowski (Slaska Akad. Med., Zabrze, Poland). was detoxicated by desferrioxamine in vitro anu esp. in vivo, Med. Pracy 14(5), 373-8(1963). Scrum proteins were examd. whereas EDTA detoxicated Mn and particularly Ni in vitro, clcctrophorctically in rabbits treated intravenously with HgClj and Ni, Zn, and Fe under certain conditions in vivo. Both or Hg(OAc)s (3 mg./kg.). Significant departures from the chelating agents promoted the urinary excretion of he in the normal levels were noted with total protein (6.12-6.60 g. % rs. rabbit, while EDTA enhanced the urinary excretion of Mn and 7.08 n normal animals), albumin 2.81-3.(X) vs. 3.92), globulin