Document wDgaDGZmn6xR30x8D1n2bMxZV
r SCEDREE Ee ARUGZGy O35
3M
Fluorochemical Control Study
This is a report of a cross-sectional correlation analysis of medical surveillance data collected in 1981ofDecatur chemical and film plant workers and their total organic. fluorine levels. There were no statistically significant correlations reported between SGOT, SGPT, GGT, alkaline phosphatase, total bilirubin, red blood cells, hemoglobin
and cholesterol for either the Decatur chemical or film plant workers. The report was
reviewed by Dr. Leonard Schuman, Professor and Director ofthe University of
Minnesota Divisionof Epidemiology Department (letter attached). Although this report does not specifically mention perfluorooctanesulfonate, it is submited as it
chronologically followed the 3M Technical Report that observed
perfluorooctanesulfonate was a componentoftotal organic fluorine in the sera of5
Decatur employees.
001713
wn
To Fe Ac UBEL, M.D. - MEDICAL DEPARTMENT - 220-2502 Flom DE. ROAGH, M.D. - MEDICAL DEPARTMENT - 220-28-02 Sect Fluorochemtcal Control Study Ce May 25, 1982
oe Bi 3A
SIohaeplreetveide.w fherations.
oSftatthiest1i9c8a1l Daencaaltyusrisflvuaosropcehrefmoircmaeld In addition,
bOyntRrioklerstRuedsyeahracsh
been
Miinnnteusrontar.evieved
in
the
DeptahretmceonntcloufsioBnpsideanmigolsotgaytiasttitchael
analysesDavteare University of
oDDeortekueDehunirsptotosoreieposof.putlhaitsiosntugdryouvpass The Decatur
atsosucmoemdpatroe
nceerstiamiinlalroedxcecphtemifosrtrtyhetiersts
iPPnluaatnsthereeCvmhipeelwmo.iyceaelsPavratsicionpataiovnolubnyptlbaaorntythbsteiheteesebveeig3m1o7PlleaonmgtpilcoaanyldeesstehleecCthieomnicfaolr
TIunmbtehres sVteurdye. Smployee
AlPtlhaontughandpar3t0i6ci(poauttioonf felt to be adequate
w80o5)loownerthein Fithlem
for stavisceciy
pla(notuttooork kp5a0r)t Film Plant these
vork
vithiInn
the the
cFhielmmicPallanptlagnrtouvpasvitrhemomvoerde
thon fron
evaluation. tthhirseecomnotnrtohls
Any history group.
or
PSahheovsseperhaalPtoatpseuesl,tatGirGoeTnsPsu)l,tvsesrosemuecchomapsarleidvevritehnzryemsepsec(tSCtOoT,thSeGPdTisatlrkiabluitnieon or
Blood cell count), `choleshteermoalt,olaongyy lpaasytalmyctoerngsan(ihcemfolguloorbiinne alnedverlesa.
pPnlhoaosnsutembamlnrodyo,dthotvseeestfIonruenstduhlentosFislbinegtnwiefeincanetmpldoigfafceerewnocrekiinng tihne
distribution the Chemical
of
tSoiteanlifoircgaannticcorfrleuolraitnieo.n betwePelnantthecsoentfronet &rroeuspu.lts Tahnedreblvoaosd allesvoelnso of
ouTuhereseifmlaurboelrseouclhtteosnidfceuamrlotnhsetrractoenfeivrimdeonucre colfini1c1ailnesismpircesdsiisoenastehat to date ve
exposed employees.
patterns among
hEEefrafelomtrihtnsievtsahiloeuusaltditoocnoshnetlipnuelovtenr rbeldouocdingflueomrpilnoeyeeseveexrpeo"sureFollow-up
nd AE
satvrucotuuersteioonfs,thipvslielalpsreobgercaaclmoln.itsinpuerdeseantoly ruesguelrarrebvaiseiws..
Timing If there
BFs/er
001714
5
Pluorochemical Control Study
ftohroomsaejvoerralcheymeiacrasl hpelaalntth ptahsetseerncsvaluations was fo
dpeervotadelurucmatitinioeonnswhseihttaehvsee.r boereTnhenocbpounradnpuyocsteedofat
(1) 2nd
to (2)
tthoeoftehxdepiospseruaersseeencocfoeuledomfplboetyheedseeestecfttloeudocreortcthhaaeitnntmeiFagilhustorobeshosneilnactseed
of the workers.
sn the eiood
CTnoooiadgaacdttdeiiotnnioonpoafaltttesottraunldioebfslodohidasdeaonsrogetanhibacseenfbleupeeonrrfiiondreemnetdi.fiedO.neHowawsevtehre, cpolnatnrtole.mployees. The other was to develop alesvueilsfaboine ohemtoal
wfnaoospurnuennodcfentrtethdaekseebny batethcoaanmeapnlauavfnaaticltasubirtlieengwiinth198t1w.o seTphaeractoentdroilviesstaundyy
m2ro0eb0li,aytlaiirvtdeyslyofalpaotrwhte.sienmcpAellloytewwoeesresebpe3aMtrwaepterenodsuitcthteeisotnwlooecmaspittleeodsy.aeepswp.arsosxadimeerpeely
were tnvolved.
manufacturing divisions
JOcfommeppcaoerbreftdeacinwteirvbeel:oowdas tetsotscosmepeanreattheeacihncpildaenntc.e oTfhoasbenortemsatls. vaieluerse
21.. sSeGoPTr 3il. qAalpprhaline phosphatase 65.. HCehmoolgelsotbeirnol 7. Red Blood Count cilpinnoicramlalassweasssmteontb.e any variation
, from normal
despite
npeottwheeenr othbejseectbilvoeodwastestto blood organic fluorine.
sreeseulitfs tahnedrethweasleaveclosrroeflattiesonnl
au"hnmiepclhocvheaeemmsoincgatlakoetphlaepnratrttheiimnnpglsaoysgienncaelprupadrleosxhieamaaltctehhleymiesv4ta5rl0yuapteioopnle.annuensssey treegsutlianrgplayr1stviicdsoiinpteastiaotbhnoearidnjoiatnhtecopmhlmeaeanrlttchiaslitteest.teisntgingts vavneprrwoufhniotsamecysoaThle
001715
SSFTtahonernaeln.urosriTgnhagensiecdeptfaelrsuttosmreinnwteeretbhlsropoodaucgehtdoeusttosvetrhwee1r9ye8e1adrraamwagrn SseebpoarCahteemliycailn ngorxege.arPneciathsuielonf.lfouroTrhitenhreeefaloneravele,ylstiaclcathlhaonugdgeehtdernsmolitonwadltryiaowndn.u'ssitmoounelLdteoalivnasayreisdaetnitontso in inaccureamciystriny tphreoficloem'patrhiissonwaswitnhotthtehocuhgehmtisptnryiepirnoemfoaiulsjelo.ry with p3e1r7soenmnpello.yees participated including severaloffice
aEoTnrrhageeaanaFigiculsmlfylpulaobnreteinneeimnpbvlloooloydvsedtaepseptiritonhxgei.rmaitnHeelryheea6l0at0gh'aiPneevoapilcearatnodn,hadnornotin Ba2enrdoWuiRsjieitnmcathreyr.dsapye.rTsheedsIneaamedomdnpilgtoiytoehneesbclwhoeeormdeicfatlleusoptrleiadnnetinseaammpppleaiorauytceiaeccsipmoaantninotehnre was jaceoenantptrhrieifnuegrpdiuermcarw2en1tah0inendtrhatewankneunornspertsohmepsttvlaaytniotfnoo.llthoeTwhiemnugrbsiteohseed sfeeealemus.iosnrnpirtnoheteocFoillm normal rountgi,ne.packaging and deliver to St. peu' co 1s sthfeor
C3pih0drr6eondtueicmftpiileoodnyeeawssorkhpeaarvrsit.nigciwpoWaritkteehddinanindthitwhseer"geroohauelpnmtooasnrtyyenetmiprleoyleye
of e2e10mosnotlheslywefrielmrpelmaonvtedefmrploomyetehsi,s grouy crepaltaintngfaorsuobvgerroup
fIanlefsuemrneanrtyl,y tpsting was
fbteehlettwebeltonoodbtehefliudtoewnrotiinpcelaalnstaswm.iptlheisOntwheererhtaondolie;dblood
three groups to be analyzed were:
meen groups. The
21.: PFChiholepmmiiePclaaaylnhto'Plaaetnmtpolnoeeymeptelisomyeeienshcaldu(d3si1pn7e)gntapspormoeximately' 33% of
3. PTchthoeusmieiscuafslilmpelxappnloatsnutr(e3e0m6t)po.lotyheeeschwehmoicahladpleasnstetnitmiealilny innoe
aattttaacchheedd. results and statistical analyses(2a1c0e) "me
001716
PRELIMINARY DATA
ANALYSIS "ABNORMAL" LIVER ENZYMES FILM VS. CHEMICAL PLANTS
TT
LOCATION
CHERILCA
FILM
Fw
CMIHNEUMSPLWAONRTKE>R3S MION
uBR TESTED
[7 Tse [oo
EMPLOYEES WITH 1 OR
MORE "ABNORMAL" ENZYMES
37 (11.3%) 26 (8.5%) | 20 (9.59)
NUMBER ABNORMAL TESTS
66TP SGPT ALK. P'TASE
24 (65%) | 12 (46D) 11 (30%) 9 (35%) 6 (16%) 7 (27%)
10 (50%) 7 (35%) 3 (15%)
% OF ALL TESTED
WITH ABNORMAL:
66TP SGPT ALK. P'TASE
(7.3%) (3.4%) (1.8%)
(3.9%) (2.9%) (2.3%)
(4,82) (3.37) (1.5%)
IF GGTP REMOVED FROM ALL TESTED % OF PEOPLE WITH "ABNORMAL ENZYMES"
5.8%
6.9%
7.1%
|| |
i
|
|| 001717
|
-
Dichs) = Bay chr
Film dt Foe bos
Fimst wf Jom 206 is
CORPORATE MLDICAL CORRELATIONS BETWEEN LIVER VALUES AND FLUORINE
S LIVER TEe ST || DEm CATUW FIe LM || DECCn AHTEUMKICAFLILMD WORWKITEE HKOSUT E || DECL ATUR TCIHETMIECRAL
scot
11 lLs0109s1ue
II 1L601306947
|1 =203,206s839)
nl 213
Veal
SGPT
|1 =L06.al0s2682
|1 7072504664
1| =e04.7075440
es
Gete
1.243
I 0.07622
) 7mem en8
1 =0,0575
1=0.00369)
_
meen
|I 1540-
fal Ere een
v| Lyehov
deme Lee em
[VRaY
eel einen
ALKPHOS || -706.3001766 [1.s09t3r58
|1.l0e2s9z25
mmm
f[I ed
1edyg
idgU ee
TelLl
mmm
f_ [| e=E0Ee.E05e 636 ei|1d =e06.2015ee69
1 |I =L06,u0s32291
Rac
I1 =l0a.o0s9570 I1 =e03,6073386
11 =i07.9001872
Hsobommes1 en-0S.L086m24err1e=l0.l017e5m7anmmenennannnn1l7s=e0d.6i1i1m5m9mmennnnn
1 1402
1 +8080
I 8719
CmHOmLEmSTEmROeLe|rno.,E 03607 11 .040q 5d 1 11e -0.07620
| 15378
I is720
I 2672
mmm 'me B wl I o l ' q
NOTESF:IEKCSOTNDVAVLAULEUE 1S15COTHMEWELSAITGINOINFICBAENTCWEEENPKOLBIAVEBRILITTEYSTOFANDTHEBLOCOODRREFLLAUTOKIIONNE
001718
CCUAKLPCOURLAATTEIONMEDIINCVAOLLVECORORNELYLATEIMOPNLOSYEBEESTWEFERNOM LICVHEERMOLVIATLEUESHAVAINNDGFL1U98O1RINHEEP
LIVER TEST
1 | CHEMOLITE
1 1
sS eoT em1m.em 0m1e81e 1 s1
I 27748 1
I |
.
SC6oPeTmmmmemee
mmm I-.10291
1
I e103) ro
| i
mmm GoTH
femme I 06442
1
I +3084 |
I 1
Semmes ALKPHUS
fmm 1.12979
|
I 40395 |
I 1
mmm TolLl
|m -0.e 108e 45 n
| 1
1.0858 1
1 1
aC meme 1m-e0m.0e8e 738ee)1
mem
1.1693 1
| 1
fee}
rob
| =0.,04083 1.5216
1 ro
Smee
1 eee
1
CRULESTEROL | .12222 I .0526
I |
meme
1 mmm
I
Ase
1.08278
|
|1.1859
i i
Be tt
Exams
NOTE: FSEICSOTND VAVLAULEUE ISIS COTHRERELSAITGNIIOFNICBAENTCWEEENPROLBIAVBEIRLITTEYST OFANDTHEBLOCOODRKEFLLAUTOIROINNE 001719
3p ny
i I 31 UNIVERSITOYF MINNESOTA
1+ voir yt ture an,
PC rioi r, e Mesn ossea $3455
April 29, 1982
mn ~
ARE 032
420Me.dicFarlankDirUebecltlor
M2e2d0i-c2al 3MDepCaernttmeernt, Medical Services St. Paul, MN 55144
Dear Dr. Ubell,
otfheyopur1rotrodececopelanrttlfmyoernhtaanddonthtehfeloudoparptooacrhteufmnriioctmaylthaeendxpsottsuhuderieepssrivuininldeeogrneteakooeffnyeoxbuayrmiDrn.ingRoach
cuhnedmeircaylourpljaunrtissdwiictthioan.contIrowlas poppruolvaitdieodnwidtrhawninffroommataiofnilomn ptlhaent
.
spaitzieono,f tthhee crleisnpieccatlivelapbloarnattorpyoputleasttisonosn,setvheeraelxtebnltoodofpatrhaemierteprasr,tici-
ptahteteirnntservianlsthoefsetpeosptuinlgatifoonrs balnododthfeludoartianedelreivveelds, thtehreefdriosme.ase
and te1 swtaisngiomfprethsesedblwoiotdhstahmeplecsareandtatkheen tionsiagvhotidanbdiassopinhisctoilclaetcitioonn opfatitohne dinatatheanahleyasletsh btyestHianwgkinwsasonvoalndunMtcaCroyrmtahcek.resAplotnhseougihn pthaerticchie-mical tPphlaeatnitocnonwtairsno]hthiepglhahneatsa,ltwhoaulletdhvoaulbguehateixToponewecwrtaesd(3e0(v63e1no7uthouitgohfeorf6.0)04)5,0)P.waarsti(dcTeiheepmaetpdiaornatdieciiqn-uate fofor3comnotnrtohls oprurmpoosrees.wereThopsreopecrolnytroslest wahpoartdidas haavesepeaarraltieersuebxgproosuupr.e
chemisItnryexnaomitneiwnogrthtyhewedriestrthiebutsiiomnislaroiftitehse armeosnuglts211on thtehegrcoluipnsi.cal cAlltihnoiucgahl" tfleusotrsiwneereTeivneslisgnirfeivceaanlte.d increases, correlations with the
tciloinnsicIaonlf teshxeucahmaibnstaeestntcieonreosfaunldatnsythaedsigseefnoaersreaSlGpOaTts,tiemrSinGlsPaTr,ietliaielcskitaelidinnebtyhephhoidssiptshtoarrtiyabsuae-n,d GcGoPnTc,ludceholtehsattervoilr,tuahlelmyoglnoobienvidaenndceredforbloeovednceplrle-ccloiunnitcsa,l onteoxmiucsitty
001720
AVpr.rilFra29n,k U1b9e8l2l page two
eexxpisotssu.re aConmdpabrltomoedntfalluiozraitnieonleovfelst,healdtahtoaugohn aa rsepfeicntermuennto,f wloeunlgdth of tphreobasbtlryatyaiweoludldTbiettlreeduocrednotoaddiintaidoenqaulateinfloervemlastiofnorsisnicgeniftihceanNc'es. in
eliciCtionngtinpuoesdsibclleiniccharlonifcollfolwuuoproconarbaonn antnouxailcitbaysiwsoulwdithbe a fveaiseiwblteo and worthwhile in your setting.
data. Thank you for permitting this appraisal of your protocol and
Sincepely A
:
add its
=~" PLreoofneasrsdorM. anSdchuDmiarne,ctoM.rD.
LHS:sn
001721