Document wDdawyq306r6XkpwgYZGj4R3E

; -w." - `i- - i * il Iniufltrlal_Hjrglene Dlgfeat - 43___ _,August, 19^9 953 Efficiency of Various Types of Artificial Respiration at High Altitudes. KJf. blood and F.E. D'Amour. An. J. EfayBlol. lj?t>. 52-bl (1949). Comparative results vith yarlous techniques far artificial respira Zhe tion are tabulated. Coranlne vaa effective In atInulating respiration at low altitudes but not at high altitudes. Other stimulants studied at low altitudes.vere caffeine, strychnine, plcrotozln, metrazole, and potass 1- un cyanide. Of these, only strychnine approached coranlne In effective ness. Bats vere maintained far about 25 minutes by diffusion respiration vith oxygen as the'dlffuslon gas. Hellun-oxygen mixtures offered no ad vantage over pure oxygen, end decreased the survival time of the animals. V --Chen. Abate. i y 956 D1Isopropyl riuophoaphate: Site of injection and Variation In Response. A.M..Freedman and H J5. Blnvlcb. Am. J. Phya lol. 15b, 125-12d (19U9) A study of lethality vith different sites of Injection shoved that the brain is the part of the body most sensitive to dllsopropyl fluophos- phate, the cause of death being respiratory. Hie liver managed the largest doses vith least general effects. Injection of the substance Into one common carotid artery produced an lnverslve syndrome consisting In part of jiy farced circling movements to the side opposite the Injection. When arti ficial respiration vaa used to avoid respiratory failure, large doses of V*, dllsopropyl fluopboephate precipitated grand mal type of brain vaves. Hie {: subsequent Injection of atropine restored the normal pattern. Atropine given before the doses prevented the development of the grand mal pattern. If - Chem. Abets. il >) 5 957 The Absorption and Excretion of fluorides III Further Observations on 5 Metabolism of Fluorides at High Levels of Intake. B.J. Largent and F.*. feeyroth. J. Ind. Hyg. A Tox. J>1, 134-130 (May, 1949). Ingestion of fluoride to the extent of 12 to 25 mg. per day. In the ! farm of the aqueous solution of a salt, resulted In absorption varying from 93 to 97$ of the Intake. Of the amount absorbed, 37 to 46$ vas stored In the tissues. When solid salts, other than sodium fluoborate vere Ingested In the amounts of 6 to 36 mg. per day, the amount absorbed varied from 62 to 77$ of the Intake. Of the amount absorbed, 34 to 45$ vaa stored In the tissues. With corresponding quantities of sodium fluo * borate, the quantities absorbed vere 98$ of the amounts ingested. Hie quantities excreted vere slightly In excess of those vhlch could be acc ounted for by the absorption of fluoride as fluoborate. Hie concentration i in the urine Increased as the average amount of fluorine absorbed dally Increased, and concentrations averaging betveen 3 and 17 ng. per liter t vere observed during the periods of elevated fluoride Intake. -- Authors' Summary The Extra-thyroid Mechanism In the Prevention of Fatty LlverB by Mexhyl- < i tnlouracll In Acute Phosphorus Poisoning. A. Qranatl Lad A. Fralonla. RHa Med. 37-61 (l9lt9T. Italian/0 Hie fatty liver degeneration In phosphorus poisoning In rats vas pre $ vented vhether methylthlouracll vas given alone or combined vith thyroid **T**,o~'* v-< 1 Irv---n ^v. y* y* [ | I `J 1 h i1