Document wDRQeZdz9obDvJL1GxbE1ydN6

DOW CHEMICAL U.S.A. 2020 Dow Center May 3, 1973 MIOLANO. MICHIGAN 48640 Mr. A. B- Steele Operations Manager Chemicals and Plastics Union Carbide Corporation 270 Park Avenue New York/ N- Y. 10017 Mr. Anton Vittone President B. F. Goodrich Chemical Company 6100 Oaktree Blvd. Independence, Onio 44131 Mr. Dick Reynold^ Vinyl Chloride Business Shell Chemical Company One Shell Plaza Houston, Texas 77002 Center Gentlemen: Attached are the recommendations that I talked with you about- today. I would appreciate your comments as soon as possible. Sincerely, 11m Attachment G. J. Williams Executive Vice President f-j m AN OPERATING UNIT OP THE DOW CHEMICAL COMPANY 5- r* OUTLINE OF PROPOSED PRESENTATION TO GOVERNMENT I. Presentation A. Government - Dr. M. Key, Director of NIOSH and others he may suggest as a result of a preliminary contact to set up meeting. ., MCA - K. Johnson and/or G. Best of MCA. Industry: Technical Business Dow V. K. Rowe G. J. Williams Goodrich A. Vittone or; T. Nantz Shell ucc H. Kusnetz D. C. Dernehl II. What should be presented - A. U. S. companies represented by presentation. B. History of Toxicity Studies 1) Review of past toxicity studies 2) Past epidemiological studies -- Acroosteolysis 3) Work reported by Viola 4) History of TLV's (lit.) C. Toxic Work in Progress 1) . MCA toxicity studies 2) MCA epidemiological studies 3) Meaningfulness of work in progress. (What questions will be answered or go unanswered.) 4) Dow work in progress. see D. Assessment of the whole problem - Review of vinyl chloride and PVC industry an<5 how it relates to toxicity problem. 1) Production (U.S. and world) a) Volume - past, present, future b) Producers c) Workers exposed - number d) Exposure levels 2) Uses a) PVC i) ii) iii) iv) Producers Uses and volume of Number of workers Exposure levels each .1 b) Copolymers . i). ii) iii) Uses and volume of each Number of workers Exposure level . . c) Aerosol i) ii) iii) Volume and use Exposure level in use Estimated number of people d) Other i) Intermediates ' E. Recommendations for Action 1) Control a) Discontinue use in aerosols ~n_ m ao o b) Lower TWA to 50 ppm (Reassess after work in progress is completed.) see 5-2185 / * 2) Future Research a) -Toxicity studies (additional) i) Establish dose response for carcinogenic action. This will require large numbers of test animals in order to be statristically valid. ii) Determine mechanism of action Investigate effe'ct of high concentration of VCB on (-SH) . If (~SH) is reduced, then establish dose-response; then attempt to counter act by supplementation with (-SH). (If action is as hypothesized, then strength of a no-effect concept is_ markedly enhanced.) - 3) Establish working contact at NIOSH Solicit NIOSH participation in whatever toxicology program is adopted. (Consultation, advice, support in whatever context seems more appropriate.) see =.-2