Document w5k7zLdg4mrEoXKMKgV1RRRQ

*VRD 0822025934- Vista Chemical Company Butadiene Concentrate Description: Vista Butadiene Concentrate is a colorless hydrocarbon, rich in 1,3-butadiene. It is produced at Vista Chemi cal's ethylene plant in Westlake, Louisiana. Applications: Butadiene Concentrate is suggested for use as a feedstock in the production ofhigh-purity butadiene. Such butadiene may then be used to produce synthetic rubber, plastic resin, and other chemicals. Properties 1,3 Butadiene, wt% C4 Acctylencs,wt % Total Cj's and heavier, wt % Peroxides, as HjO*. wt. ppm Sulfur,wt. ppm Inhibitor,TBC,wt. ppm Specification 65 min. 2 max 1 max 10 max lOmax 200 max Typical 70 1.1 <0.5 <1.0 <1.0 150 Safety and Handling: Butadiene Concentrate is classified by DOT as a flammable gas and should be handled accordingly. Buta diene Concentrate is a simple asphyxiant and exposures to high concentration may result in dizziness and unconsciousness. Contact with the product in liquid form can result in frostbite-like burns. THE DATA CONTAINED HEREIN ARE FORGENERAL INFORMATIONAL PURPOSES ONLY. PLEASE REFERTOTHEVISTACHEMICAL COMPANY MATERIAL SAFETY DATASHEET FOR SPECIFIC,COMPLETE INFORMATION REGARDING THIS PRODUCT. Storage and Transfer: Tank construction materials, storage conditions, handling equipment and procedures must be incompliance with specific pressure vessel codes and OSHA regulations dealing with the storage and hand ling of liquified petroleum gases. Availability: Vista Butadiene Concentrate is available in railcars from Westlake, Louisiana. VISTA Viiu iiatrademariof Vista OtamkatCompany. The above daca are baaed on teat* and experiencewhich Visa Chemical Company believea reliable,and are supplied foe informational purpose*only.Viati Chemical Company and io subsidiary.Vista Polymers Inc.,disclaim any liability for damage or injurywhich results from the use ofthe above data and nothing contained therein shall constitute a guarantee, warranty or represenration (including freedom from patent liability) by Vista Chemical Company orViata Polymers Inc. with respect to the data,the productdescribed or theiruse for any specific purpose,even ifthat purpose is known to Vista ChemicalCompany or Visa Polymers Inc. For detailed informa tion regarding these products, please referto the respective Vista Chemical Company orVista Polymers Inc. Material Safety Dsia Sheet 1701A-M0O45-1/85-1M Vlcta Chemical Company Headquarters Vista Chemical Company 15990 N. Barker's Landing Rd. Post Office Box 19029 Houston,Texas 77224 Phone (713)531-3200 Telex 794557, TWX 910-881-7329 FAX(7l3) 531-3236 Domestic Soles Offices Eastern Region Park 80 Plaza East Saddle Brook, NewJersey 07662 Phone (201) 845-3800 FAX(20l)845-6807 Midwestern Region 2222 Camden Court, Suite 120 Oak Brook, Illinois 60521 Phone (312) 655-7070 FAX(312) 655-7086 Southwestern Region 15990 N. Barker's Landing Rd. Post Office Box 19029 Houston.Texas 77224 Phone (713) 531-3200 Tfelcx 794557,'TWX 910-881-7329 FAX(713) 531-3236 Western Region Smoketree Plaza 1450 N.Tustin,Suite 100 Santa Ana, California 92701 Phone (714) 541-8449 FAX(714) 541-0567 International SalesOffices Vista Chemical Latin America S.A. 15990 N. Barker's Landing Rd. Post Office Box 19029 Houston.Tcxas 77224 Phone (713) 531-3200,Telex 794557 FAX (713) 531-3236 Vista Chemical Europe HiltonTower Boulevard deWaterloo, #39 B1000 Brussels, Belgium Phone (32-2)513-7490 Telex 24727 Cable-. VISTA B Vista Chemical Far East, Inc. PostOfficc Box 110 Kasumigaseki Building, 25th floor Tokyo, japan 100 Phone (81-3) 593-0611 .Telex 29368 Cable: VISTACHEM,Tokyo FAX 011-813-593-0615 Butadiene Concentrate C3 VISTA m SZBZ880 9CM10Z000 Vista Chemical Company Ethylene Dichloride Description: Vista Ethylene Dichloride (EDC) is a volatile liquid with a characteristic odor resembling that ofchloroform. EDC is a high purity' grade suicable forVCM manufacture. Applications (EDC): Vista ethylene dichloride is used as a chemical intermediate in the manufacture ofvinyl chloride monomer, chlorinated solvents, ethylenediamine, succinonitrile, and glycol ethers and esters. It also can be used as a sol vent in a wide variety ofapplications, as a fumigant, and as a lead scavenger in octane boosters containing lead. Properties Ethylene Dichloride,wc.% Acidity (as HC1), ppm Residue on Evaporation, ppm Water Content, ppm Molecular wc. Color, APHA Specific Gravity, (20/20C) Density, (15.6C).Jb/gal. Flash Point TCC,C Boiling Point (760 mm),C Distillation Range,C Explosive Mixtures With Air@ 20C Upper Limit, vol. % Lower Limit, vol. % Specification 99 min. 10 max. 20 max. 100 max. -- 10 max. 1.252-1.256 -- -- -- 100% within 2? including 83.5 Typical >99 3 10 30 99.0 8 1.254 10.5 17 83.5 100% within 1.5? including 83.5 15.6 6.2 Safety and Handling: Excessive exposure to EDC is hazardous since it is toxic by inhalation, oral intake or skin contact. Exposure to moderate concentrations can cause nausea, narcosis and subsequently anesthesia. Ethylene dichforide has been shown to produce cancer in animals. Depending on conditions ofuse, special precautions and care may be nec essary for the handling of EDC. THE DATA CONTAINED HEREIN ARE FORGENERAL INFORMATIONAL PURPOSES ONLY. PLEASE REFERTO THE VISTA CHEMICAL COMPANY MATERIAL SAFETY DATASHEET FOR SPECIFIC, COMPLETE INFORMATION REGARDING THIS PRODUCT. Storage and Transfer: Y'ista ethylene dichloride may be stored in mild-steel tanks and drums without risk ofcorrosion or deterioration. However, in the presence of free water, hydrolysis occurs. The hydrolysis is slow ac normal temperatures but is accelerated by heat and alkalis. Care should therefore be taken to store ethylene dichloride away from heat and possible wacercontamination. Availability: Vista ethylene dichloridc is available in tank cars or bulk sea shipments from Westlake, Louisiana. Contact Vista Chemical Company for information regarding water shipment. VISTA Villa is a trademark of Vjj/j Chtmtea/Compawj. The above data ire based on teals and experiencewhich Visu Chemical Company believes reliable, and are supplied for informational purposcsonly. Vista Chemical Company anil its subsidiary,Visa Polymers Inc.,disclaim any liability for damage or injury which remits from the use ofthe above data and nothing contained therein shall constitutc a guarantee, warranty or representation (including freedom from patent liability) by Vista Chemical Company or Visu Polymers Inc. with respect to the data, the product described or their use forany specific purpose, even ifthat purpose is known co Visra Chemical Company or Visu Polymers (nc. For detailed informa tion regarding these products, please refer to the respective Visu Chemical Company or Visu Polymers Inc. Material Safety Date Sheet I503B-M1138-11/84-1M Vista Chemical Company Headquarters Vista Chemical Company 15990 N. Barker's Landing Rd. Post Office Box 19029 Houston,Texas 77224 Phone (713) 531-3200 Telex 794557,TWX 910-881-7329 FAX (713) 531-3236 Domestic Sales Offices Eastern Region Park 80 Plaza East Saddle Brook, New Jersey 07662 Phone (201)845-3800 FAX (201 >845-6807 Midwestern Region 2222 Camden Court, Suite 120 Oak Brook, Illinois 60521 Phone (312) 655-7070 FAX (312) 655-7086 Southwestern Region 15990 N. Barker's Landing Rd. Post Office Box 19029 Houston.Texas 77224 Phone (713) 531-3200 Telex 794557, TWX 910-881-7329 FAX (713) 531-3236 Western Region Smoketree Plaza 1450N.Tustin,Suite 100 Santa Ana, California 92701 Phone (714) 541-8449 FAX (714) 541-0567 International Sales Offices Vista Chemical Latin America S.A. 15990 N. Barker's Landing Rd. Post Office Box 19029 Houston,Texas 77224 Phone (713)531-3200, Telex 794557 FAX (713) 531-3236 Vista Chemical Europe Hilton Tower Boulevard de Waterloo, #39 B1000 Brussels, Belgium Phone (32-2)513-7490 Telex 24727 Cable: VISTACHEM, Brussels Vista Chemical Far East, Inc. Post Office Box 110 Kasumigaseki Building, 25th floor Tokyo, Japan 100 Phone (81-3) 593-06U,Telex 29368 Cable: VISTACHEM, Tokyo FAX 011-813-593-0615 Ethylene Dichloride 30 C5 VISTA 6i f 5 1 6 1 6 0 6 Vista Chamkal Company Haadquartars Vista Chemical Company 15990 N. Barker's Landing Rd. Post Office Box 19029 Houston,Texas 77224 Phone (713) 531-3200 Telex 794557, TWX 910-881-7329 FAX (713) 531-3236 Domestic Sales Offices Eastern Region Park 80 PlazaEast Saddle Brook, New Jersey 07662 Phone (201) 845-3800 FAX (201) 845-6807 Midwestern Region 2222 Camden Court, Suite 120 Oak Brook, Illinois 60521 Phone (312)655-7070 FAX (312) 655-7086 Southwestern Region 15990 N. Barker's Landing Rd. Post Office Box 19029 Houston,Texas 77224 Phone (713) 531-3200 Telex 794557,TWX 910-881-7329 FAX (713) 531-3236 Western Region Smoketree Plaza 1450N.Tustin,Suite 100 Santa Ana,California 92701 Phone (714)541-8449 FAX (714) 541-0567 International Sales Offices Vista Chemical Latin America S.A. 15990 N. Barker's Landing Rd. Post Office Box 19029 Houston,Texas 77224 Phone (713) 531-3200, Telex 794557 FAX (713) 531-3236 Vista Chemical Europe HiltonTower Boulevard de Waterloo, #39 BI000 Brussels, Belgium Phone (32-2)513-7490 Telex 24727 Cable: VISTACHEM, Brussels Vista Chemical Far East, Inc. Post Office Box 110 Kasumigaseki Building, 25th floor Tokyo.Japan 100 Phone (81-3) 593-061 LTclcx 29368 Cable: VISTACHEM, Tokyo FAX 011-813-593-0615 VCM Vinyl ChloHda Monomer VISTA VRD 0002025939 Vista Chemical Company VCM Vinyl Chloric!* Monom*r Description: Vista vinyl chloride monomer (VCM) is a high purity, clear, colorless, sweet smelling gas at ambient tempera ture and pressures. It polymerizes readily in the presence ofair, sunlight, oxidizing agents, and free-radical cat alysts, to form a hard, white resin-polyvinyl chloride (PVC). Applications: Vista vinyl chloride monomer is used in the manufacture of polyvinyl chloride for use in pipe and pipe fittings, siding, window profiles, and food grade packaging and bottles. It is also compatible with a variety ofvinyl mono mers such as vinyl acetate, ethylene, propylene, vinylidene chloride, and acrylates in the manufacture ofcopoly- mers. Vista vinyl chloride monomer is suitable for use as an intermediate in the manufacture of 1,1,1-trichloroethane for use as a solvent or degreaser. Properties Vinyl Chloride, Wt.%* Specification 99.98min Typical 99.98 Water, ppm Methyl Chloride, ppm 100 max 70 max <50 <50 Acetylene, ppm 2 max <1 1,3-But-eiJiene, ppm Total C4 Ur.sacurates 12 max 40 max <10 <20 Acetaldehyde, ppm Non-Volatiles, ppm 1.0 max 25 max <0.5 nil Iron (non-filterable), ppm 0.15 max <0.1 Acidity(as HCI), ppm 1 max nil Oxygen in Vapor Space, ppm, vol. before loading after loading 1,000 max 500 max <350 - FreezingPoint, C -153.7 BoilingPoint,C -13.8 Flash Point(COC), C Specific Gravity, Liquid(20C/20C) -78 0.9121 Density, (20C), Lb./Gal. Solubility(H20inVCM),Wt.% 7.6 0.11 Explosive Limits (Volume in Air), Vol. % UpperLimit LowerLimit excludes water,oxygen and non-volatiles. 22.0 4.0 NOTE: For export shipment up to 5 ppmofhydroquinone inhibitor will be added. Safety and Handling: When inhaled at high concentrations, vinyl chloride monomer acts as an anesthetic. Prolonged exposure to excessive amounts ofVCM may cause cancer. Vinyl chloride is a highly flammable gasand can easily ignite at most normal atmospheric conditions.The handling, use and exposure to VCM in the workplace is strictly regu lated by OSHA. Refer to 29 CFR, Part 1910.1017 for specific requirements. THE DATA CONTAINED HEREIN ARE FORGENERAL INFORMATIONAL PURPOSES ONLY.PLEASE REFERTOTHE VISTA CHEMICAL COMPANY MATERIAL SAFETY DATASHEET FORSPECIFIC, COMPLETE INFORMATION REGARDING THIS PRODUCT. Storage and Transfer: Score Vista vinyl chloride in steel tanks, eicher under refrigeration or under pressure at atmospheric tempera tures. Do not use vessels or fittings made ofcopper or aluminum or their alloys. Blanket storage tanks with inert gas, and neveral low air to enter the tanks. In the presence ofwater.VCM accelerates thecorrosion ofiron orscecl. Availability: Uninhibited orinhibited grades ofVista vinyl chloride arc shipped asa liquid in pressurized cankcars from West- lake, Louisiana. Product can be made available in bulk vessels, for barge or vessel liftings. Contact Vista Chem ical Company for information regarding water shipment. Vuu itatradrmiri ajVista CAemicaiCamptr*]. The above data are baaed on tests and experience which Viica Chemical Company believes reliable, and are supplied fix informational purposes only. VisasChemical Company and ns subsidiary. Vises Polymers Inc..disclaim any liability fordamage or injury which results from the use ofthe above data and nothingcontained therein shall conatituce a guarantee, warranty or reptesentatioA (including freedom from patent liability) by Vista Chemical Company or Vista Polymers Inc. with respeettothe data, the productdescribed ortheic use for any specific purpose, even ifthat purpose is known to Vista Chemical Company orVista Polymers Inc. Foedetailed informa tion regarding these products, please refer to the respective Viua Chemical Company or Vista Polymers Inc. Material Safety Dau Sheet. IS02B-MHI4.il/94-IM VIS1A VRD 0002025940 Flynt Kennedy A c. L. Whetstone D. A. Kuhn R. M. Tillman W. R. Beaty A. J. Lundeen W. R. Sorenson Date 7/23/76 i r .r < . c J t *' O. C. Kerfoot has this 343-page report should you need information. lm enc - title page: "Suspected Carcinogens-- A Subfile of the NIOSH Toxic Substances List," by H. E. Christensen, et al, Tracor Jitco, Inc., Rockville, Maryland - June 1975 cc w/report: i -Tm >A VRD 00w202594i VRB 0002825942 KEEP UP TO DATE Between the time you ordered this report-- which is only one of the hundreds of thou sands m the NTIS information collection avail able to vou--and the time you are reading this message, several new reports relevant to your interests probably have entered the col lection. 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You will receive a notice n your microfiche shipments identifying the excep tionally priced reports not available 1 Trough SRIM. A deposit account with NTIS *s r quired before this service can be initiated. If you have specific questions concerning th s serv ice, please call (703) 451-1558, or writ > NTIS. attention SRIM Product Manager. This information product distributed by U S. DEPARTMENT OF COMMERCE National Technical Information Service 5285 Port Royal Road Springfield, Virginia 22161 BIBLIOGRAPHIC DATA SHEET 1. Report No. 2. _ NTOSH 7S-1RR______________________ np `D OA A QQ/ 4. Title and Subtitle 5. Report Date Suspected Carcinogens--A Subfile of the NIOSH Toxic Substances List 7. AuehorCs) June, 197S 6. ^ R3 r-o S3 8. Performing Organization Rejri?. HE Christensen. TT Lueinhvhl. ES Carroll 9. Performing Organization Name and Address <2 10. Projeet/Task/Work Unit Ng Tracox Jitco, Inc. 1776 E. Jefferson S Rockville, Md. 20852 11. Contract/Granc No. CDC 99-74-92 12. Sponsoring Organization Name and Address National Institute for Occupational Safety and Health/CDC/ DHEW 5600 Fishers Lane Rockville, m 20852 13. Type of Report & Period Covered 14. 15. Supplemeatary Notes 16. Abstracts The publication is the first of several subfiles to the NlftSH Toxic Substances File. For the purpose of this compilation, agents causing beign or malignant tumors are classed as carcinogens. The objectives of this edition is to list in one place 1) all chemicals identified as having carcinogenic activity as reported in the literature, 2) meet general information needed on potential chemical carcinogens and 3) provide documentation in support of the Suspected 1500 Carcinogens List published by NIOSH in the Federal Register. This compilation should provide ready reference for potential carcinogenicity of chemicals found in the workplace. 17. Key Words and Document Analysis. 17o. Descriptors Carcinogens, toxicity, tumor, neoplasm, cancer 17b. Ideotifters/Open-Ended Terms PRICES SUBJECT 17e. COSATI Field Group 18. Availability Statement FORM NTIS-38 (Rev. io-73> Reproduced by NATIONAL TECHNICAL INFORMATION SERVICE US Depertmenl of Commerce Springfield. VA. 22151 ENDORSED BY ANSI AND UNESCO. 19.- Security Class (This Report) UNCLASSIFIED 20. Security Class (This Page UNCLASSIFIED THIS FORM MAY BE REPRODUCED 21. No. of Pages US COMM- P C S209-P74 m s m e a s aha KEY TO ABBREVIATIONS (Refer to Introduction for Elaboration of Definitions) AI.R allergenic effects BCM - blood clotting mechanism clTects bdw -- wild bird species BLD -- blood effects BPR -- blood pressure effects brd -- bird (domestic or lab) C -- continuous Cl --ceiling concentration CAR -- carcinogenic effects cat -- cat chd -- child ckn -- chicken CNS -- central nervous system effects COR -- corrosive effects ctl -- cattle CRIT DOC --criteria document COM -- cumulative effects CVS -- cardiovascular effects D -- day dek -- duck DDP -- drug dependence effects DEF -- definition dog -- dog dom -- domestic EVE -- eye effects frg -- frog GIT -- gastrointestinal tract effects GLN -- glandular effects gm -- gram gpg -- guinea pig grb -- gerbil H -- hour ham -- hamster hmn -- human I -- intermittent ial -- intraaural iat -- intraarterial ice -- intracerebral iev -- intracervical idr -- intraderma! idu -- intraduodenal ihl -- inhalation imp -- implant ims -- intramuscular inf -- istfafit ipc -- intraplacental ipl -- intrapleural ipr-- intraperitoneal irn -- intrarenal IRR -- irritant effects isp -- intraspinal itr -- intratracheal ivg -- intravaginal ivn -- intravenous kg -- kilogram (one thousand grams) LC50 -- lethal concentration 50 percent kill I do - lowest published lethal concentration I.D50 -- lethal dose 50 percent kill 1 Dl.o -- lowest published lethal dose mam -- mammal (species unspecified) man -- man M -- minute m3 -- cubic meter mg -- milligram (one thousandth of a gram; 10-:: gm) mky -- monkey MMI -- mucous membrane effects MSK -- musculo-skeletal effects MTH -- mouth effects mus -- mouse MUT mutagenic effects NEO -- neoplastic effects ng -- nanogram (one billionth of a gram: 10-u gm) ocu -- ocular orl -- oral par -- parenteral pg -- picogram (one trillionth of a gram; 10"*- gm) pgn -- pigeon pig -- pig Pk -- peak concentration PNS -- peripheral nervous system effects ppb -- parts per billion (v v) pph -- parts per hundred (v v) (percent) ppm -- parts per million (v v) ppt -- parts per trillion (v v) PUL -- pulmonary system effects qal -- quail rat -- rat RBC -- red blood cell effects rbt -- rabbit rec -- rectal scu -- subcutaneous skn -- skin SKN -- skin effects sql -- squirrel sup -- super script SYS -- systemic effects TCLo -- lowest published toxic concentration TDLo -- lowest published toxic dose TER -- teratogenic effects TFX -- toxic effects TOX REV -- toxicology review trk -- turkey TWA -- time weighted average TXDS -- qualifying toxic dose ug -- microgram (one millionth of a gram; 10-*1 gm) unk -- unreported UNS -- toxic effects unspecified in source USOS -- U.S. Occupational Health Standard W -- week WBC -- white blood cell effects wmn -- woman Y -- year l - 6L/ VKD 6002 0 2 5 H 5 Suspected Carcinogens A Subfile of the NIOSH Toxic Substances List Herbert E. Christensen, D.Sc. Editor Thomas T. Luginbyhl Editor Benigna S, Carroll Project Coordinator U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Public Health Service Center for Disease Control National Institute for Occupational Safety and Health Rockville, Maryland 20852 June 1975 F<r eele by the Superintendent ot Deeunrnti, U.S. Qortmmtnl Printing Office, Washington, D.C. 30402 VRD 0002025946 Prepared for the National Institute for Occupational Safety and Health under Contract Number CDC 99-74-92 by Tracor Jitco, Incorporated 1776 East Jefferson St. Rockville, Maryland 20852 DHEtf Publication No. CNIOSH) 75*188 VRD 0002025947 A FOREWORD This publication is the first in a series of subfiles extracted from the National Institute for Occupational Safety and Health (NIOSH) Toxic Substances List. The objective of this edition is to assemble in one list all chemicals identified as having carcinogenic activity as reported in the literature. For the purpose of this compilation, agents causing benign or malignant tumors are classed as carcinogens. This is because of the possibility that agents which cause benign tumors may also produce malignant tumors. This publication is intended to meet general information needs on potential chemical carcinogens as well as to provide the documentation for the list of approximately 1500 chemical substances published by NIOSH in the Federal Register. In the Toxic Substances List program NIOSH, for the past four years, has been collecting and disseminating information on the health effects of chemicals including carcinogenic effects. Last year we conducted a comprehensive review of the primary literature and an accelerated attempt to collect current as well as retrospective information. The 1500 chemical substances identified so far have demonstrated carcinogenic activity from studies reported in the literature. However, no critical evaluation of the test protocol or derived data has been per formed. In addition, the actual presence of the chemical in the workplace has not been determined and no attempt has been made to correlate the test data with the physical state or purity grades of chemicals found there. Thus, NIOSH is requesting additional information for its programs in occupational carcinogens identification and recommended control. This compilation should provide ready reference for potential carcinogenicity of chemicals found in the workplace, and should be useful to occupational health physicians, industrial hygienists, toxicologists, and researchers. A better under standing of potential workplace health problems through the use of this compila tion hopefully will facilitate the achievement of a healthful workplace. John F. Finklea, M.D. Director, National Institute for Occupational Safety and Health m A VRD 00020 2 5 H 8 CONTENTS INTRODUCTION------------- vii CRITERIA FOR THE TOXIC SUBSTANCES LISTix Selection------------------------------------------------------Format------------------------------ ix ix Generalix Substance Prime Name___ ._____ _--ix The Chemical Abstracts Service Registry Numberx The Molecular Weight_____________________________________x The Molecular Formula------------------------------------------------------------------ x Wiswesser Line Notation--------------------------------------------------- _x Synonyms x Toxic Dose Data --------------------------------------------------------------------------- x Cited Referencexviii U.S. Occupational Standardsxviii NIOSH Criteria Documentsxx ACKNOWLEDGMENTS _____________ _xxi APPENDIXES ____________ -xxiii I. Occupational Safety and Health Standardsxxiii II. Standard for an Occupational Exposure to Asbestosxxvii III. Occupational Safety and Health Standards -- Carcinogens--------------- xxxi IV. Standard for Occupational Exposure -- Vinyl ChlorideIxxiii V. Worker Protection Standards for Agricultural Pesticideslxxxiii VI. Criteria Documents Published by NIOSH ________________________ lxxxvii VII. Requests for Health Hazards Evaluationlxxxix THE TOXIC SUBSTANCES LIST1 BIBLIOGRAPHIC REFERENCES329 Preceding page blank v bnS IB IB B B FIGURES 1. An example of a typical entry in the Toxic Substances List.......................--xi 2. A typical toxic dose line from the Toxic Substances List................. ............. xii TABLES I. Limiting Dosages Differentiating Relatively Toxic and Nontoxic Substances According to Route of Administration to Experimental Animals of a Maximum Total (Acute) Dose causing Death...................._xiii II. Routes of Administration to, or Exposure of, Animal Species to Toxic Substances .................................................. -............................ --xiv III. Species (Including Order of Preference for Data Acquisition) ___ _______ xv IV. Assumptions for Toxic Dose Calculation from Non-Specific Data..........Jtvii V. Units of Time for Dose Administration ........... ........ ............................. _xviii VI. Notations Descriptive of the Toxicology........ ................................ _..............xix vi INTRODUCTION This 1975 Edition of suspected carcinogens is the first in a series prepared under the "useful grouping" provision of Section 20(a)(6) of the Occupational Safety & Health Act of 1970, Public Law 91-596. This list contains approximately 1500 chemical substances which were selected from the full toxicological file for their carcino genic effects as determined in whole animal stud ies. For those chemical substances selected, we have included the entire file entry: descriptors, molecular weight, molecular formula, structural notation, synonyms, toxicity data and references, and pertinent occupational standards. The purposes for presenting these data are manifold and serve a variety of uses. This list serves as a single source document for toxic sub stance information; including such data as chem ical properties and standards information for those toxic chemicals for which standards have been promulgated. This presentation of the vari ous types of toxic effects referenced by original studies will allow researchers and occupational health specialists an introduction to the literature, thus facilitating their review of the toxic hazards of a substance. Through the collection and pre sentation of the lowest reported doses by several routes and various species, valuable information is made available to those who have responsibility for preparing safety data sheets for chemical substances in the workplace. Through the use of this list, chemical and production engineers can identify the relative hazards which may be asso ciated with the use of chemical intermediates for the development of final products and, thus, can determine the use of substitutes or alternate proc esses which may be less hazardous. By using various indexes in the automated file, association of chemical structure to the toxic effects produced by a chemical may be possible and, thus, enable some prediction of what to expect from a newly synthesized chemical. In offering this edition we recognize its limi tations in achieving the purpose that we have set for it. First, it may not include all demonstrated carcinogenic substances. Such a goal can not be achieved without the full cooperation of the sci entific community. Cooperation in the form of personal contributions will become increasingly imperative as the list becomes more nearly com plete. The absence of a substance from this list does not imply that a substance is not a carcinogen; only extensive testing would lead to that con clusion. It must be reemphasized that the entry of a substance on the list does not automatically mean that it must be avoided. A listing does mean, however, that the substance has the po tential of being hazardous if misused and, there fore, care must be exercised to prevent tragic consequences. Thus, there will be found on the list many substances which are common in every day life and are in nearly every household in the United States. It is not the purpose of the list to quantitate the hazard through the use of the toxic concen tration or dose that is presented with each sub stance. No attempt has been made to resolve any question about data that have been published. Of necessity, we rely on editing provided by the scientific community prior to any publication in scientific literature. Under no circumstance can the toxic dose values presented with these chem ical substances be considered as being definitive values for describing safe concentrations for hu man exposure. Concentrations of chemical sub stances in man's working environment which may be safely tolerated can be determined only by a critical evaluation of all available pertinent data by experienced investigators. A critical evaluation of a chemical hazard involves much more than a determination of the toxic potency, no matter how complex the deter ti a a mination may be. A ha2ard evaluation must include such a determination, of course, but toxic potency and degree of hazard can not be con sidered as being synonymous. Identifying and defining a chemical hazard must also include the evaluation of the amount and duration of expo sure, the physical characteristics of the substance, the physical conditions under which exposure oc curs and the determination of the presence of other chemical substances. All of these may sig nificantly alter the toxic potency of a substance which, in turn, may alter the health of the person who may become exposed. NIOSH, under its criteria development pro gram, conducts critical reviews of occupational hazards. The resulting criteria document thereby provides a valid detailed support for the standard as recommended by NIOSH for the Department of Health, Education, and Welfare to be used by the Department of Labor as a basis for its promul gation of a standard. The standards referenced in this list as U.S. Occupational Standards (U.S.O.S.) state the con centrations of substances which have been deter mined to provide a safe, healthful work environ ment for all persons. These may also include, within the limits of technical feasibility and in accord with such other considerations as made by the U.S. Department of Labor, methods for sampling and analyzing; engineering controls; appropriate personal protective equipment and clothing; emergency procedures; medical surveil lance procedures; use of signs, labels, and placards to identify the hazardous substances; and the requirement for apprisement of the workers of the hazard to which they are exposed. A standard for an occupational exposure to vinyl chloride was promulgated under The Occu pational Safety and Health Act during 1975. AH standards appear in the Appendixes. As of the date of publication of this list, there have been 23 criteria documents for recommended standards forwarded to the Department of Labor. A list of these documents appear in Appendix VI. The Williams-Steiger Occupational Safety and Health Act of 1970 in Section 20(a) (6) directs that the Secretary of Health, Education, and Welfare ". . . shall determine following a written request by any employer or authorized representa tive of employees . . . whether any substance normally found in the place of employment has potentially toxic effects in such concentrations as used or found . . . ." The manner of implementing this activity is found in 42 CFR Part 85, in the Federal Register volume 37, number 215, pages 23639 through 23642, November 7, 1972. Both the reference and the forms to be used in requesting assistance from NIOSH are found as Appendix VII. The Toxic Substances List, by providing a convenient mechanism for recognizing potentially hazardous chemicals, may assist those interested in identifying the substances in the workplace which may be hazardous to health. We request and will appreciate whatever assistance may be offered by representatives of the industrial, academic, and governmental com munities in supplying data for this list. This assistance may be offered in the form of reprints of scientific publications, of technical data sheets, of sales or promotional material, or any other pub licly available reference material, of data pre sented by personal letter for previously unpub lished studies or by notification of errors. All material received will be considered as part of the public domain and as such may be made available to any persons or organizations. vm VRD 000202595? CRITERIA FOR THE TOXIC SUBSTANCES LIST Selection 1. Substances. For the purpose of this list the phrase "all known substances" that exhibit car cinogenic activity was interpreted to include all mined, manufactured, processed, synthesized and naturally occurring inorganic and organic com pounds. The list may include drugs, food addi tives, preservatives, ores, pesticides, dyes, deter gents, lubricants, soaps, plastics, extracts from plant and animal sources, plants and animals which are carcinogenic by contact or consump tion, and industrial intermediates and waste prod ucts from production processes. 2. Substances Excluded. Excluded from The Toxic Substances List file and, therefore, this publication were trade name products represent ing compounded or formulated proprietary mix tures available as commercial products. These exclusions were necessary because of difficulties in assessing the contribution to the toxicity by each component of the mixture and because the com ponents of those formulations can be and are often changed by the producer by substitu tion of different chemicals with different toxic effect potential or through varying the concen trations. Trade names have been included on the list where they represent a single active chemical entity. These substances may be impure com mercial products of relatively constant composi tion and will be identified by definitions of com positions rather than by a Chemical Abstracts Service Registry Number, molecular formula or Wiswesser Line Notation. Radioactive substances are now included but the effect reported is due to the chemically produced effects rather than to the radiation effects. Format 1. General. The list is made up of a series of toxic substance items which are arranged in alphabetical order. Each name is preceded by a seven character code consisting of two letters of the alphabet followed by five digits. The number code varies directly with the alphabetic sequence of the substance name on the list and will not change in subsequent revisions except where se quence errors are discovered and must be cor rected. Following the name of the chemical sub stance are lines containing definitive descriptions of the synonymous names, substance, toxic dose information with references, and references to existing and recommended standards and to NIOSH's criteria for recommended standards. Ab breviations used can be identified in the pages that follow or by reference to the glossary on the inside of the front and rear covers. A schematic entry is shown in Figure 1. 2. Substance Prime Name. We have estab lished the prime chemical name of each chemical for this list to be the nomenclature used by the American Chemical Society Chemical Abstracts Service (CAS) in the 8th collective index of chem ical abstracts which is in the inverted form. With this preferred prime name, the reader may find the CAS Registry Number, molecular weight, molec ular formula, Wiswesser Line Notation, syno nyms, toxic data, and other pertinent information. Some entries, however, appear as a chemical or descriptive name as published in the source from which the toxic data were derived. This is par ticularly true for those substances for which some aspects of the composition are in question such as plant or animal extracts. These prime names will be accompanied by a definition or description (DEF:) which may be a narration including the source, a generally accepted statement of constitu ents or other helpful information, with a reference source. Numerals, Greek letters, and prefixes in dicating substituent locations, and stereochemical IX VRD 0002075^53 or other structural features are ignored in the first alphabetical ordering. These components are taken into account for secondary ordering in ascending numerical order and alphabetically within alphabetically similar substances. When the line item entry is a name that is other than a prime name, such as a trade name, common name, or coined name, a cross reference is given to the sequence number and name of the prime entry with the available data. 3. The Chemical Abstracts Service Registry Number, (CAS): is a designation which uniquely identifies a specific chemical compound. The value of such an entry is that it allows one to always conclusively recognize a chemical com pound, regardless of the name or naming system used. The numbers used in this publication were derived from the Desk Top Analysis Tool* (DAT), the Chemical Abstracts Indexes, and various other sources. 4. The Molecular Weight, MW: is calculated from the molecular formula as was presented by the DAT, from the article of reference, or from the formula derived from the name. 5. The Molecular Formula, MOLFM: desig nates the elemental composition of the chemical and is entered according to the rules presented in the DAT. 6. Wiswesser Line Notation, WLN: was as signed when available. The WLN is a line-form ula chemical notation describing in a concise and precise manner the structural formula of a chem ical compound. This formula enables substructure searches for special functional groups and sub stituents that are found in this molecule. The WLN descriptions will allow machine retrieval of entries by chemical characteristic which may facil itate analysis. It also should aid in recognition of certain substructure-activity relationships. 7. Synonyms, SYN: This line is devoted to synonyms for the prime name substance listed. All synonyms found will be listed in alphabetical order following "SYN:" according to the same rules presented for ordering the substance on the first line. Each name will be separated by an asterisk. Synonyms are other chemical names, trade names, common or generic names. 8. Toxic Dose Data, (see Figure 2.) This section contains the toxic dose or concentration and the result that qualified the substance for inclusion as a potential carcinogen on the list. Desk Top Analysis Tool for the Common Data Base (6 volumes) 1968: NTIS**PB 179-900. Additional lines of toxic dose information for other routes of administration, for other effects, or for other species may be present. These are entered as additional information or references in order to more fully define the toxic nature of a sub stance. All of the entries in the toxic dose section contain information entered according to the fol lowing pattern: The first line starts with the notation "TXDS:" immediately followed by the qualifying toxic dose information. The entries then following indicate, in sequence, the route of ex posure; the species of animal involved; the type of dose; the amount of substance per body weight or concentration per unit air volume and, where applicable, the duration of exposure; a descriptive notation for the type of effect reported; and, lastly, the reference source from which the information was extracted. The additional entries after the first line are not preceded by "TXDS." Each ele ment of this further toxic dose data line is dis cussed below. a. Qualifying Toxic Dose (TXDS). All toxic doses appearing on The Toxic Substances List were derived from reports of the toxic effects pro duced by individual substances. A toxic effect is defined as any bodily injury -- reversible or irre versible; any tumor -- benign or malignant; any mutagenic or teratogenic effect; or death which has been reported to have resulted from exposure to a chemical substance via the respiratory tract, skin, eye, mouth, or any other route. For humans the toxic effect is any toxic effect that was reported in the source reference. There is no qualifying limitation to the duration of expo sure nor to the quantity or concentration of the substance, nor is there a qualifying limitation of the circumstances that resulted in the exposure. Regardless of the absurdity of the circumstances that were involved in a toxic exposure, it is assumed that the same circumstances could recur. For a substance to be included, there is no limita tion as to the time of exposure, nor the quantity or concentration of the dose of the substance reported to have caused neoplastigenic, or carcin ogenic effects in animals. This is because a doseeffect relationship has not been correlated for animals and man. It is presumed that there is some potential for the occurrence in man of effects similar to those noted in animals if man is exposed to these substances. For the practical purpose of identifying the substances producing carcinogenic effects, we ac cepted statements by authors that the effects found x FIGURE 1. An example of a typical entry in the Toxic Substances List, 1975. 2) DS17500. BERYLLIUM | ^ CAS: 007440417 MW: 9.01 MOLFM: Be WLN: .BE SYN: GLUCINIUM * >TXDS: ihl-hmn TCLo:300 rag/m3 TFX:PUL scu-pig TDLo:7 mg/kg TFXrNEO U.S. OCCUPATIONAL STANDARD USOS-air:TWA 2 ug/m3;CL5 ug/m3 CRIT DOC: OCCUPATIONAL EXPOSURE TO BERYLLIUM. N^ ' AEHLAU 9,473,64 AIHOAX 3,81,51 FEREAC 37,22139,72 NTIS** PB210-806 1. Identification number in this listing, see 1. in text below. 2. Prime name of compound, see 2. in text below. 3. Chemical Abstracts Registry Number, which is a number assigned to this compound so that it may be uniquely identified, see 3. in text below. 4. Molecular Weight of this compound, see 4. in text below. 5. Molecular Formula or Elemental Formula of this compound, see 5. in text below. 6. Wiswesser Line Notation, which is a formula defining the structure of this compound, see 6. in text below. 7. Synonyms, common names, trade names, and other chemical names, see 7. in text below. 8. Toxic dose line, which defines the route of administration or entry of this substance, the species involved, the type of dose reported, the dose which caused the toxic response, and the type of toxic response noted from the dose administered, see 8. in text below. Also see FIGURE 2. 9. This is the reference to the original article or source from which the toxic data was derived, see 9. in text below. Also see FIGURE 2. 10. U.S. Occupational Standard exists for this substance in the regulations of 0SHA, U.S. Department of Labor, see 10. in text below. The standard may be found in the Federal Register referenced here. 11. A Criteria Document supporting a recommended standard has been published by NI0SH, U.S. Department of Health, Education, and Welfare. See 11. in text below. The reference contains the published Criteria Document. tStSlBlBBB ANA FIGURE 2. A typical toxic dose line from the Toxic Substances List, 1975 (This figure is a further explanation of items 8 and 9 in FIGURE 1.) 8a. An acronym which stands for "Toxic Dose". 8b. This is an abbreviation for the route of administration or entry of this substance. See Table II for other routes of entry used in the list. 8c. This is an abbreviation for the species. S*e Table III for the other species used in the list. 8d. This is the type of dose reported. See 8d. in text below. 8e. This is the dose which caused the toxic effect. See 8e. in text below. 8f. The first part of this notation, "TFX", is an acronym which stands for "Toxic Effects". The last part of this notation refers to the organ system affected by the dose administered. See Table VI below. 9. This is a code denoting the reference from which the toxic data was derived. The reference for this code may be found in the Bibliography. See 9. in text below. 9a. Volume number of the reference. 9b. Page number of the reference. 9c. These two digits stand for the year of publication, i.e. 1964. AHA TABLE I LIMITING DOSAGES DIFFERENTIATING RELATIVELY TOXIC AND NONTOXIC SUBSTANCES ACCORDING TO ROUTE OF ADMINISTRATION TO EXPERIMENTAL ANIMALS OF A MAXIMUM TOTAL (ACUTE)* DOSE CAUSING DEATH** SPECIES (with abbreviations) ROUTES OF ADMINISTRATION (with abbreviations) Oral (orl) (rec) Intraduodenum (idu) Intracervix (icv) Inhalation (ihl) Maximum Skin (skn) Parenteral Intraperitoneal Subcutaneous (ipr) (scu) Intrapleural Intradermal (ipl) (idr) Implant (imp) Intravenous (ivn) Intramuscular (ims) Ocular (ocu) Intracerebral (ice) Intratracheal (itr) Intraplacental (ipc) Intravaginal (ivg) Intr&rena! (im) Hamster (ham),Frog (frg), Gerbil (grb) Rat (rat), Mouse (mus). Mammal, unspecified (mam) Rabbit (rbt), Guinea Pig (gpg). Chicken (ckn), Pigeon (pgn), Quail, (qal), Duck (dck), Turkey (trk). Bird (brd) Dog (dog). Monkey (mky). Cat (cat), Pig (pig), Cattle (ctl), Domestic Animals: sheep, goat, horse (dom) mg/kg 2,500 ppm 5,000 (0.5%) 5,000*** 10,000 (1%) 10,000 20,000 (2%) mg/m3 1,000 2,000 4,000 mg/kg 1,400 mg/kg 1,000 2,800 2,000 2,800*** 4,000 10,000 20,000 (2%) 4,000 5,600 4,000 mg/kg 5,000 10,000*** 20,000 mg/kg 750 1,500 3,000 20,000 3,000 Other (par) Unreported (UDk) mg/kg 1,000 2,000 4,000 mg/kg 2,500 5,000 10,000 4,000 10,000 Applies to those substances for which acute or short term toxicity characterizes the response, e.g,, fast-acting substances, irritants, narcoses-producing substances and most drugs. Does not apply to substances whose characteristic response results from prolonged exposures, e.g., silica, lead, benzene, carbon disulfide, carcinogens. Concentrations more appropriately characterizing the toxicity of long- or slow-acting substances arc derived from non-acute toxicity studies. Calculated from experimental data (Stokingcr). From Hine and Jacobson, AIHAAP 15, 141, 54. 9S6SZ0Z000 OMA > on a were reported according to accepted classifica tions. TTius, if the effects were reported as being carcinogenic or neoplastigenic by .the author of a report, these reported classifications were ac cepted. A substance is listed as a neoplastigen if one significant tumor was reported according to a classification by the number and type of tumor produced. If a substance was reported to have produced a malignant tumor or one that metasta sized to other parts of the body, the substance is listed as a carcinogen. Although these classifica tions are noted, it is the current policy of NIOSH to classify chemicals as carcinogenic if they pro duced tumors (benign or malignant) in animals. The report of the lowest dose administered over the shortest time to produce the toxic effect was given preference; though some license was taken in order that data cited in different references might be entered. Data from animal experimenta tion resulting in death must be selected and limited by some criteria. All substances, when administered in sufficiently high quantities or con centrations over a sufficient length of time, will cause death. Therefore Table I is included as set- TABLE II ROUTES OF ADMINISTRATION TO, OR EXPOSURE OF, ANIMAL SPECIES TO TOXIC SUBSTANCES Route Intracerebral Intracervical Intradermal Intraduodenal Inhalation Implant Intramuscular Intraplacental Intrapleural Intraperitoneal Intrarenal Intratracheal Intravaginal Intravenous Ocular Oral Parenteral Rectal Skin Subcutaneous Unreported Abbreviation ice icv idr idu ihl imp ims ipc ipl ipr irn itr ivg ivn ocu orl par rec skn scu unk Definition administration into the cerebrum administration into the cervix administration within the dermis by hypodermic needle administration into the duodenum inhalation in chamber, by cannulation, or through mask placed surgically within the body -- location described in reference administration of dose into the muscle by hypodermic needle administration into the placenta administration of dose into the pleural cavity by hypodermic needle administration into the peritoneal cavity administration into the kidney administration into the trachea administration into the vagina administration of dose directly into the vein by hypodermic needle administration directly onto the surface of the eye or into the conjunctival sac per os, intragastric, feeding introduction with drinking water administration into the body through the skin. Reference cited is not specific concerning the route used. Could be ipr, scu, ivn, ipl. ims, irn. or icc administration of dose by way of rectum to the rectum or colon in form of enema, suppository application to the intact skin, dermal, cutaneous administration under the skin dose, but not route, is specified in the reference xiv ting reasonable upper limits for toxic lethal dos ages. b. Route of Exposure or Administration. Al though most exposures to substances in the indus trial community occur through the respiratory tract or skin, most exposures reported in the published literature concern studies of experimen tal animals in which the test substances were in troduced through the mouth by pills, in food, in drinking water, or by intubation directly into the stomach. Therefore, for purposes of developing infor mation concerning the relative toxicity of sub stances, toxicity studies by all exposure routes are reported. The abbreviations and definitions of the various routes of exposure used in this listing are found in Table II. c. Species Exposed. Since the effects in the human are of primary concern we have indicated, when available, whether the results were observed in man, woman, child or infant. If no indication is made in the reference, the term "human" is used. Results of studies on rats and mice are the most frequently reported, and hence, are the most use ful data for comparative purposes. The species TABLE in SPECIES Species bird -- any domestic or laboratory bird reported but not otherwise identified bird -- wild bird species cat cattle chicken dog domestic animals: goat, sheep, horse duck (domestic) frog gerbil guinea pig hamster human infant mammal -- species unspecified in reference man monkey mouse Pig pigeon quail (laboratory) rabbit rat squirrel toad turkey woman Order of Preference for Data Acquisition 22 23 7 11 17 4 12 19 20 13 9 10 1 1 15 1 6 3 8 16 18 5 2 14 20 21 1 Designation brd bdw cat ctl ckn dog dom dck frg grb gPg ham hmn inf mam man mky mus PE Pgn qal rbt rat sql tod trk wmn xv VRD 0002025^58 A 6$fi S Z S IB B S and abbreviations used are listed alphabetically in Table HI. d. Description of Exposure. . In order to de scribe the entered dose more completely, six ab breviations are used. These terms indicate whether the dose caused death (LD) or other toxic effects (TD) and whether it was administered as a lethal concentration (LC) or toxic concentration (TC) in the inhaled air. Their definitions are as follows: TDLo-Toxic Dose Low -- [he lowest dose of a substance, as published or made known to us, introduced by any route other than inhalation over any given period of time and reported to produce any toxic effect in man or to produce carcinogenic, teratogenic, mutagenic, or neoplastigenic effects in humans or animals. TCLo-Toxic Concentration Low -- any con centration of a substance in air to which man or animals have been exposed for any given period of time and that has been reported to produce any toxic effect in man, or to produce a carcinogenic, teratogenic, mutagenic, or neoplastigenic toxic effect in animals or humans. LDLo-Lethal Dose Low -- the lowest dose of a substance other than LD50 introduced by any route other than inhalation over any given period of time and reported to have caused death in man or the lowest single dose introduced in one or more divided portions and reported to have caused death in animals. Entries for lethal doses admin istered to animals for the qualifying toxic dose, TXDS, were made in accordance with the dose limits of Table I. LD50-Lethnl Dose Fifty -- A calculated dose of a chemical substance which is expected to cause the death of 50% of an entire population of an experimental animal species, as determined from the exposure to the substance, by any route other than inhalation, of a significant number from that population. Other lethal dose percentages, such as LD1, LD10, LD30, LD99. may be pub lished in the scientific literature for the specific purposes of the author. Such data would be pub lished in the list if these figures, in the absence of an LD50, were the lowest published in the article. A substance may qualify by an LDLo published value even though a higher LD50 value, which may also exceed the limits of Table I, was re ported in the same publication. LCLo-Lethal Concentration Low -- the low est concentration of a substance, other than an LC50, in air which has been reported to have caused death in man or to have caused death in animals when they have been exposed for 24 hours or less. Entries for lethal concentrations for animals for the qualifying toxic dose, TXDS, were made in accordance with the dose limits of Table I. LC50-Leiha\ Concentration Fifty -- a calcu lated concentration of a substance in air, exposure to which for twenty-four hours or less would cause the death of 50% of an entire population of an experimental animal species, as determined from the exposure to the substance of a significant number from that population. These entries qual ified in accordance with the dose limits set forth in Table I. See LD50 above for other parameters which may similarly apply to entries for the list. e. Units of Dose Measurement. As is found in almost all experimental toxicology studies, the doses are given in terms of the quantity adminis tered per unit body weight or quantity per unit volume of the respired air. In addition, where applicable, the duration of time over which the dose was administered is also listed. The dose, whether it was reported in terms of weight or volume, was entered in terms of units of weight. Milligrams per kilogram (mg/kg) were pre ferred, but in some cases, because of dose sizes, grams per kilogram (gm'kg), micrograms per kilo gram (ug-'kg), or nanograms per kilogram (ng./kg) were used. Volume measurements of dose were converted to weight units by the appropriate calcu lations, assuming all liquids to have a density of one for a conversion of one milliliter to one thou sand milligrams. All body weights have been convened to kilo grams (kg) for uniformity. For those references in which the dose was reported to have been administered to an animal of unspecified weight or a given number of animals in a group (e.g., feeding studies) without weight-data, the weights of the respective animal species were assumed to be those found in Table IV and the dose was listed on a per kilogram body weight basis. For the references in which similar information was presented for man or woman and no weight data were provided, the weight for man was assumed to be 70 kilograms; for woman, 50 kilograms; and for child, 20 kilograms. Assumptions for daily food and water intake are found in Table IV for approximating doses per individual animals where the dose has been exposed as a concentration in food or water. The values presented are selec tions which are reasonable for the species and xvi convenient for dose calculations. These values would be used in lieu of other more exact available data. other measurements of contaminants are used such as fibers or particles, the measurement is not abbreviated but is spelled out, e.g., for asbestos 1.2 fibers/cc. TABLE IV ASSUMPTIONS FOR TOXIC DOSE CALCULATION FROM NON-SPECIFIC DATA* Species Consumption Water Age Weight Food mi/day gm/day (Approx.) Cat, adult Chicken, adult (male or female) Dog, adult Duck, adult (domestic) Frog, adult Guinea pig, adult Hamster Monkey Mouse Pigeon Rabbit, adult Rat, adult female Rat, adult male Rat, adult sex unspecified Rat, weanling 8W 52 W 8W 14 W 2.5 Y 8W 8W 12 W 14 W 14 W 14 W 3W 2 kg 100 100 500 gm 200 200 10 kg 250 500 2.5 kg 250 500 33 gm 500 gm 30 85 125 gm 15 85 5 kg 400 500 25 gm 5 5 500 gm 2 kg 100 330 200 gm 10 20 250 gm 15 25 200 gm 15 25 50 gm 15 25 NOTE: Values given here are within reasonable limits usually found in the published literature and are selected to facilitate calculations for data from publications in which toxic dose information has not been presented for an individual animal of the study. Data for lifetime exposure are calculated from the assumptions for adult animals for the entire period of exposure. For definitive dose data the reader must review the referenced publication. All concentrations of a substance in air are listed preferably as parts of vapor or gas per million parts of air by volume (ppm). As may be convenient for effective presentation, parts per hundred (pph or per cent), parts per billion (ppb). and parts per trillion (ppt) may be used. If the substance is a solid or a liquid, the con centrations are listed preferably as milligrams (one thousandth of a gram) per cubic meter (mg 'm3) but may, as applicable, be listed as micrograms (one millionth of a gram; 10_,; gram) per cubic meter (ugym3), nanograms (one bil lionth of a gram; 10-" gram) per cubic meter (ng m3), or pico grams (one trillionth of a gram; 10-1- gram) per cubic meter (pg m3), of air. Where the original source listed the concentration measurements of a liquid in volume units, the density of the chemical was assumed to be one thousand milligrams per milliliter and was con verted to milligrams. For those cases in which For some studies, e.g., inhalation, carcinogen, mutagen, teratogen and feeding studies, the dura tion of exposure is pertinent to the dose informa tion. For those studies, time will be presented as indicated in Table V. In all cases the total duration of exposure appears first after the kilo gram body weight and slash followed by descrip tive data; e.g., 10 mg/kg/3WI means ten milli grams per kilogram body weight administered over a period of three weeks, intermittently in a number of separate, discrete doses. It is intended to provide the reader with enough information for an approximation of the experimental condi tions which can be clarified by studying the article cited. f. Notations Descriptive of the Toxicology. The toxic dose line thus far has indicated the route of entry, the species involved, the descrip tion of the dose, and the amount of the dose. xvti VRD 000 20 259-6 ^ A VRD 0002025961 Unit Minute Hour Day Week Year Continuous Intermittent TABLE V UNITS OF TIME FOR DOSE ADMINISTRATION Abbreviation M H D W Y C I Limits of Use and Definitions 1-99 minutes 1-99 hours 2-99 Days 2-99 Weeks 1-99 Years Indicates that the exposure was continuous over the time administered, such as ad lib. feeding exposures or twenty-four hour, seven-day week inhalation exposures. Indicates that the dose was administered during discretely separate periods, such as daily parenteral, oral, or skin applications. The next entry found on this line when a TDLo or TCLo is cited is the lowest dose toxic effect, "TFX:". Following "TFX:" will be one of the notations found in Table VI. These nota tions will indicate the organ system affected or will indicate in the case of animal experiments special properties that the substance demonstrates, e.g., CAR = carcinogen. No attempt was made to be definitive of the effect reported because such definition requires much detailed qualification and is beyond the scope of this publication. The selection of the dose was based first on the lowest dose producing an effect, and secondly, on the latest study published. 9. Cited Reference. The final entry of this line is the reference from which the toxic dose information was extracted. All references from which the information has been gathered are and must be publicly available. No classified govern ment documents have been used for source infor mation. All references have been given a six letter CODEN* character code which is an unam biguous manner of identifying periodicals and serial publications. The CODEN references are found in the Bibliographic References. For those references for which no CODEN was found, the six letter code includes "**" in the last one or two positions following the first four or five letters of an acronym for the publication title. In this manner, all acronyms will be found in alpha betical order. Following the CODEN designation CODEN for Periodical Titles. American Society for Testing and Materials. 1916 Race Street, Philadelphia. 19103, 1970. (for most entries) will be: the number of the vol ume, followed by a comma; the page number of the first page of the article, followed by a comma; followed by the last two numbers indicating the year. Any other designation found, will be ex plained with its reference code in the Bibliography. 10. U.S. Occupational Standards. Occupa tional standards found in Appendices I through V of this introduction are those pertaining to subject chemical substances. References to these stan dards are also included in the body of the list under the appropriate chemical substance. The format heading of these reference lines is "U.S. Occupational Standard" followed either by "USOS" or "EPA." "USOS" refers to standards promulgated under section 1910 of the Occupa tional Safety and Health Act of 1970 and "EPA" refers to Worker Protection Standards for Agri cultural Pesticides promulgated under the Federal Insecticide, Fungicide and Rodenticide Act. The references to air contaminants in Appen dix I are expanded to include the numerical limit values. Although more complex, this quantita tive information may be taken along with the unevaluated data to provide a more nearly com plete profile of the chemical. The entry following USOS is "air" which labels this as an air contaminant standard. TWA or Cl refers to either time weighted average or ceiling value. For some chemicals TWA, Cl, and Pk (peak) values are given in the standard. In those cases all three are listed. Finally some en tries may be followed by the designation "(SKIN)." This designation indicates that the xvui Abbreviations ALR BCM BLD BPR CAR CNS COR CUM CVS DDP EYE GIT GLN IRR MMI MSK MUT NEO PNS PUL RBC SKN SYS TER TFX UNS WBC TABLE VI (NOTATIONS DESCRIPTIVE OF THE TOXICOLOGY Definitions (not limited to effects listed) Allergenic-systemic reaction such as might be experienced by individuals sensitized to penicillin. Blood clotting mechanism -- any effect which increases or decreases clotting time. Blood effects -- effect on all blood elements, electrolytes, pH, protein, oxygencarrying or releasing capacity. Blood pressure effects -- any effect which changes any aspect of blood pressure away from normal -- increased or decreased. Carcinogenic -- producing cancer -- a cellular tumor, the nature of which is fatal or is associated with the formation of secondary tumors (metastasis). Central nervous system -- includes effects such as headaches, tremor, drowsiness, convulsions, hypnosis, anesthesia. Corrosive effects -- bums, desquamation. Cumulative effect -- where substance is retained by the body in greater quantities than is excreted, or the toxic effect is increased in severity by repeated bodily insult. Cardiovascular effects -- such as when heart activity is increased or decreased through an effect on ventricle or auricle; fibrillation; or when the arterial or venous system is dilated or constricted. Drug dependence -- any indication of addiction or dependence. Eye effects -- irritation, diploplia, cataracts, eye ground, blindness by affecting the eye or the optic nerve. Gastrointestinal tract effects ------ diarrhea, constipation, ulceration. Glandular effects -- any effect on the endocrine glandular system. Irritant effect -- any irritant effect on the skin, eye, or mucous membrane. Mucous membrane effects -- irritation, hyperplasia, ciliary activity changed. Musculo-skeletal effects -- such as osteoporosis, muscular degeneration. Mutation or mutagenic -- transmissible changes produced in the offspring. Neoplastic effect -- the production of tumors. Peripheral nervous system effects. Pulmonary system effects -- effects on respiration and respiratory pathology. Red blood cell effects -- includes the several anemias. Skin effects -- such as erythema, rash, sensitization of skin, petechial hemorrhage. Systemic effects -- effects on the metabolic and excretory function of the liver or kidneys. Teratogenic effects -- nontransmissible changes produced in the offspring. Toxic effects -- used to introduce the principal organ system affected as reported or the pathology. Unspecified effects -- the toxic effects were unspecified in source. White blood cell effects -- effects on any of the cellular units other than erythro cytes, including any change in number or form. xix VRD 0002025962 A VRD 0002025963 compound may be absorbed by the skin and, even though the air concentration may be below the limit value, significant additional exposure through the skin may be dangerous. The FEREAC reference is to the volume, page, and year of the Federal Register. The specific format for references to Appen dix I, II, III and V are.as follows. Appendix I U.S.O.S. -- air: TWA(C1) (Pk) value FEREAC 37,22139,72 Appendix II U.S.O.S.--Asbestos FEREAC 37,22142,72 Appendix III U.S.O.S. Carcinogens FEREAC 39,3756,74 Appendix V EPA: Farm Worker Field Reentry FEREAC 39,16888,74 II. NIOSH Criteria Documents. The last line of a toxic substance entry will indicate that a NIOSH criteria document for the support of the U.S. Occupational Standards, proposed or prom ulgated, is available at the time of printing. This line will start with "CRIT DOC:" followed by the title of the document and the source for the refer ence in terms consistent with the Bibliography. The reference citation is the National Technical Information Service, U.S. Department of Com merce, document identifier, from which paper copy or microfiche copy may be ordered. xx ACKNOWLEDGMENTS During the past year we were pleased to receive contributions for use in the Toxic Substances List. Contributions were in the form of reprints, preprints, elaborations of conference presentations, and letters containing unpublished data as well as suggested corrections. Reader participation is essential to the development of this list. User participation is potentially far more important than staff effort in collection and evaluation of data in this field. Therefore, in order to improve subsequent editions, both in quality and comprehensiveness, participation is strongly encouraged. We are grateful to those who have contributed. xxi  9 6 S Z 0 0 0 0 <IHA APPENDICES Appendix I RULES AND REGULATIONS 2213$ Subpart G--Occupational Health and Environmental Control 1910.93 Air contaminants. An employee's exposure to any mate rial listed in table Q-l, 0-2, or G-3 of this section shall be limited in accord ance with the requirements of the follow ing paragraphs of this section. (a) Table G-l: (1) Materials with names preceded by "C"--Ceiling Values. An employee's ex posure to any material in table Q-l, the name of which is preceded by a "C" (e.g., C Boron trifluorlde), shall at no time exceed the celling value given for that material in the table. (2) Other materials--8-hour time weighted averages. An employee's expo sure to any material in table 0-1, the name of which is not preceded by "C", in any 8-hour work shift of a 40-hour work week, shall not exceed the 8-hour time weighted average given for that material in the table. (b) Table0-2: (1) 8-hour time weighted averages. An employee's exposure to any material listed in table 0-2, In any 8-hour work shift of a 40-hour work week, shall not exceed the 8-hour time weighted average limit given for that material In the table. (2) Acceptable ceiling concentrations. An employee's exposure to a material listed in table 0-2 shall not exceed at any time during an 8-hour shift the ac ceptable ceiling concentration limit given for the material in the table, except for a time period, and up to a concentration Thu Uicu issuance of the Occupational Safety and Health Standards contained in Part 1910 of Title 29 of the Code of l ederal Rcgubiiom appeared in the June 27. 1974, mue of the ledcrai Register. Volume 39, Number 123. Part II. beginning with page 23.02. not exceeding the maximum duration and concentration allowed In the column under "acceptable maximum peak above the acceptable ceiling concentration for an 8-hour shift". (3) Example. During an 8-hour work shift, an employee may be exposed to a concentration of Benzene above 25 p.pm. (but never above 50 p.p.m.) only for a maximum period of 10 minutes. Such ex posure must be compensated by expo sures to concentrations less than 10 p.pjn. so that the cumulative exposure for the entire 8-hour work shift does not exceed a weighted average of 10 p.pjn. (c) Table 0-3: An employee's expo sure to any material listed in table 0-3, in any 8-hour work shift of a 40-hour work week, shall not exceed the 8-hour time weighted average limit given lor that material in the table. (d) Computation formulae: (1) (i) The cumulative exposure for an 8-hour work shift shall be computed as follows: *s=C*T4-fCr + . . . CnTm Where: 8 B Is the equivalent exposure for the work ing shift. C Is the concentration during any period of time T where the concentration remains constent, T Is the duration In hours of the exposure at the concentration C. The value of E shall not exceed the 8hour time weighted average limit in table FEDERAL REGISTER, VOL 37, NO. 202--WEDNESDAY, OCTOBER If, 1972 Preceding page blank xxiii 22140 RULES AND REGULATIONS 0-1, 0-2, or G-3 for the material involved. (li> To Illustrate the formula pre- acrlbed In subdivision (l) of this subpara graph. note that isoamyl acetate has an 8-hour time weighted average limit of 100 p.p.m, (table 0-1). Assume that an employee id subject to the following exposure: Two hours exposure at 150 p.p.m. Two hours exposure at 75 p.p.m. Pour hours exposure at SO p.p.m. Substituting this information in the formula, we have 2x150 + 2x75+4x50 ------------------------------------------=81.25 p.p.m. 8 Since 81.25 p.p.m. is less than 100 p.p.m., the 8-hour time weighted average limit, the exposure is acceptable. (2) (i> In case of a mixture of air con taminants an employer shall compute the equivalent exposure as follows: c, c. c- Ei -----1--- + . . . -- L, L, Lm Where: E* is the equivalent exposure for the mixture: C is the concentration of-a particular con taminant L Is the exposure limit for that contami nant, from table 0-1, 0-2. or 0-3. The value of E,, shall not exceed unity (1). (ii) To illustrate the formula pre scribed in subdivision <i) of this subparagraph. consider the following exposures: Material Actual con- centratlon of 8-hour exposure 5-hour time weighted avenge exposure limit . 500 p.p.m.. . 1,000 p.p.m. J-Butanone (Table 0-1).. . 200 p.p.m. Toluene (Table 0-2).. .. 40 p.p.m... . 200 p.p.m. Substituting in the formula, we have: -500 45 40 E*.=----------+------ +------ 1.000 200 200 E., =0.500 + 0.225-;-0.2 00 E,.. =0.925 Tabi.s a-i Substance p.p.m.* Acetaldehyde................................... 200 A.-tlcaclo......................................... 10 Acellc anhydride............................. 6 Acetone........................ 1,000 Acetonitrile....................................... 40 Acetylene dlcltlorlde, see 1, 2- Dlohloroethylene.......................... Acetylene tetrabromlde... 1 Acroietn.............................................. at Acrylamide--Skin............................ . Acrv lonit rile--Skin........................ 20 Aldrln--Skin...................................... Ally! alcohol--Skin......................... Allvl chloride................................... 2 1 "C Allylelycldyl ether (AQE). 10 Allyl propyl disulfide................... 2 2-Ammo'thaiiol, see Ethanol- 2-Amuiopyrldlne............................. "Ammonia................................ .. Ammonium sulfamate (Am- as 60 mate)................................................ n-Amyl acetate................................ sec-Amy! acetate............................. Aniline --Skin.................................. Anisi'line (o, p-lsomers) --Skin Antimony and compounds 100 125 5 Sb>.......................................... ANTI' (alpha naphthyl thiourea).............................. ........ Arsenic and compounds (as As) Arsine................................................ Atlnphoe-methyl --Skin............. Barium (soluble compounds).. p-Beiizoqulnone, see Qulnone. a 05 Bentoyl peroxide......................... Benzyl chloride............................. Biphenyl, see Diphenyl............. Blsphenol A, see Dtglycldyl ether.............................................. Boron oxide........... ;....................... C Boron trlfluorlde...................... Bromine............................... Bromoform--Skin......................... Butadiene (1.3-butadlene)......... a1 i as 1,000 Butanethlol. see Butyl mer captan ..... ............. ....... ............. 2-Butanone........................................ 2-Butoxy ethanol (Butyl Cel- losolve)--Skin.............................. Butvl acetate (n-butyl acetate). sec-Butyl acetate............................ tert-Butyl acetate........................... Butyl alcohol.................................... sec-Butyl alcohol............................ tert-Butyl jlcohot........................... C Butylamine--Skin..................... 200 SO 160 TOO 200 100 ISO 100s C tert-Butyl chromate (as CrOjl--Skin............................................... . n-Butyl glycldyl ether (BOB).. 60 Butyl mercaptan.......................... 10 p-tert-Butyltoluene........ ............... 10 Calcium arsenate........................................... Calcium oxide........................................ "Camphor________ ....... 3 Carbaryl (Bavin)...................................... Carbon black.................................................. Carbon dioxide............................ 5,000 Carbon monoxide.................. 50 Chlordane--Skin.................................... .. Chlorinated camphene--Skin.................. . Chlorinated diphenyl oxide...................... Since E., is less than unity (1), the expo Chlorine dioxide................ .. sure combination is within acceptable C Chlorine trlfluorlde.......... limits. C Chloroeceteldehyde................... a-C hloraacetophenone (e) To achieve compliance with para (phenacylchlorlde)................. .. graph <a> through (d> of this section, Chlorobentene (monocblorpbentene)........................................ administrative or engineering controls i o-Chlorobentylldene must first be determined mented whenever feasible. and lmple- i When such ! malononftrile (OCBM)....... Chlorobromomethetie....__ ... 2-Chloro-i.3-buUdlee, see controls are not feasible to achieve full CMoroprene................................ Chlorodiphenyl (42 percent compliance, protective equipment or any Chlorine)--Skin.......................... other protective measures shall be used Chlorodiphenyl (54 percent to keep the exposure of employees to air Chlorine)--Skin.................. .. 1-Chloro.2.3-epoxy propane, see contaminants within the limits pre Epiclilorhydrin........................... scribed in this section. Any equipment 2-Chloroethanol,4ee Ethylene chlorohydrln.................. .. and/or technical measures used for this Chloroethylene, see Vinyl purpose must be approved for each par chloride.......................................... ticular use by a competent industrial C Chloroform (trjchloro* methane)................................... .. hygienist or other technically qualified person. Whenever respirators are used, their vse shall comply with g T910.134. l-C hloro-l-nltroptopene........ Chloroplcrln............................. .. Chloroprena (2^hloro-l,3- butadlene)--Skin...................... . ai ai a os 75 aos 200 SO 2D at 25 mg./M*1 360 25 20 2,400 70 14 0. 25 0.3 45 0. 26 5 3 45 12 2 36 15 525 660 19 as 0.3 0.6 0.3 00..52 15 3 0.7 5 2,200 690 240 710 950 950 300 450 30106 0.1 270 36 60 l 6 9 3.5 9,000 65- 0. 5 0. 6 0. 5 a3 a4 3 0.3 360 0.4 1,060 1 0. 5 240 100 0.7 90 Tabl* 0-1--Continued Substance p.p.m.* 50 ____ B3_ mg./ftfS*-31 Chromium, sol. chromic, chromous salts as Cr............ Metal and truol. salts............... Coal tar pitch volatllee (ben* ten# soluble fraction) anthra cene, BaP, phenanthrene, acridine, chrysene, pyrene... Cobalt, metal fume and dust.. Copper fume................................ .. Dusts and Mists........................ Cotton dust (raw)........................ Crag herbicide............................ CresoT (ail Isomers)--Skin_____ Croton aldehyde............................. 6 2 Curame--Skin............................... Cyanide (as CNT)--Skin............ CyclohexBne.... ..................... .. Cyclohexanol.................................. Cyclohexanone............................... Cyclohexene................................... C yclopen f ad lene........................... 2, 4-D................................................. DDT--Skin.................................... 60 300 60 60 300 75 DDVP, see Dlchlorvoe............... Decaborane--Skin........................ Demeton--Skin ......................... Dlacecone alcohol (4-hydroxy* 4-methyl-2-peoianone)............ a 05 60 1.2-dlamlnoethane, see Ethylenedtarnlne...................... Dlazomethans................................ Dtborane........................................... a? ai Dlbutylphlhalate........... .............................. C o-Dlchlofobenxene..................... 60 p-Dtchlorobeniene....................... 76 Dichlorodlduororoethane............. 1,000 1.3-Dtchloro-6,5-dlmethyl hydantotn.................................................... 1,1-Dlchloroethane.............. . 100 1,2-Dlchloroethylene...................... 200 C Dichloroethyl ether-- Bktn___ 16 Dlchloromethane. see Methylenechlorlde........................ Dlchloromonofluoromethane-- 1,000 C 1,1-Dlchloro-l-nltroethane.... 10 1,2-DichLiropropan, see Propylenedtchlorlde.................... Dlchlorotetrafluoroethane........... 1.000 Dlchlorvoe (DDVP)--Skin...................... ... Dleldrln--Skin.................................................... Dlethylamlne. ................................. 26 Dlethylamlno ethanol--Skin... 10 Diethylether, see Ethyl ether...................... Dtnuorodlbromomethane....... 100 C Dtelycldyl ether (DOE)......... 05 Dlhydroxybenxene, see Hydroqulnone..................... ............................ Dllsobutyl ketone........................... 60 DUsopropylamlne--Skin....... 6 Dlmethoxy methane, see Methylal............................................................. Dimethyl acetamide--Skin......... Dlmethylamine.............................Dlmethylaminobeoxene, see 10 10 Xylidene............................................................ DlmethylanlUneCN-dimethyl- aniline)--Skin............................... 5 Dlmethylbemene, see Xylene______ ______ Dimethyl l,2-dlbromo-2,2-dl- chloroethyl phosphate, (Dlbrom).. .................................. ............. - DlmethyKormanilde--Skin.--,. 10 2.6-Dlmethylheptanone, see Dllsobutyl ketone........................................... 1.1-Dlmethylhydrwlne--Skin... CL 6 Dlmethylphthslate............................................ D'methylsulfate--Skin................. I 7. nitrobenzene (all Isomers)-- Skin............................................................. ........ ,, inltro-o-creaol--Skin.. ........................... Dlnltrotoluene--Skin........................................ Dlox&ne (Dlethylene dioxide)-- Skin................................................. 100 Diphenyl........................................... a3 Dlphenylmethane dUsocyaoate (see Methylene btsphenyl Isocyanate (MDI). .......................... .. Dipropylene glycol methyl ether--Skin.................................... 100 Di-sec. octyl phthalate (Dl-2* ethylhexylphthalate).................................... Endrln--Skin....................................................... Eplehlorhydrtn--Skin................... 5 EPN-Skin........................................................... 1.2-Epoxypropane, see Propyleneoxlde.. -........................ 2.3-Epoxy-l-propanol, see Olycldol............................................................. See footnotea at end of table. P -n <3 On H 01 .1 1 15 22 6 245 6 1,050 200 200 1,015 200 10 1 .........oo..Y1 240 ....... 6.Y 0. I 5 300 450 4,960 as 400 790 90 4, 300 60 7,000l o. 25 75 60 'geo"* 2.8 290 20 1 0.2 L5 3601 eoo 5o.i 19 xxiv RULES AND REGULATIONS A 2201 Tablb 0-1--Continued Table O-l--Continued Table Q--1--Continued Substance p.p.m.* mg./M' * Ethanethlol. aee Ethybner* captan............................................... Sthanolamlne.................................. 3-Ethoxysthanol--Skin................ 200 3rEthoxyethylacetate (Cello- solve acetate)--Skin................ Ethyl acetate................................... Ethyl acrylate--Bkln.................... Ethyl alcohol (ethanol)......... .. Ethylamlne.................................. too 400 25 1,000 10 Ethyl see-amyl ketone (4methyl-3-hepunone}...'.......... Ethyl benzene................................. fthyl bromide................................ thyl butyl ketone (3Heptanone)................................ Ethyl chloride................................. Ethyl ether....................................... Ethyl formate.................................. 25 IOO 200 60 1,000 400 100 C Ethyl mercaptan....................... Ethyl silicate.................................... Ethylene chlorohydrln--Skin.. 10 100 5 Ethylenedlamlne............................ 10 Ethylene dlbromlde, tee 1,2- nthromoethane.............................. Ethylene dfchlorlde, see 1,2- plchloroethane.............................. C Ethylene glycol dinitrate and/or Nltreerlyccrln--Skin... <0.3 Ethylene glycol monomethyl ether acetate, see Methyl celloaolve acetate........................... Ethylene Lntlne--Skin................... Ethylene oxide................................ aa so Ethyllillno chloride, see 1,1- Dichloroethane.............................. N-Ethylmorphollne--3kln.......... 20 Ferbam................................................. Ferrovansdium dust........................ Fluoride (as F).................................. Fluorine............................................. ai Ftaorotrlchlororoeihane............... 1.000 Formic acid....................................... a Furfural--Skin................................ 8 FSrfuryl alcohol.............................. SO Olycldol (2,3-Epoxy-l- firopanol)....................................... ycol mouoethyl ether, see 2-Etlioiyrthanol........................ Outhton see Atlnphoe- so xnethyl.............................................. Hafnium............................................ .. Heptachlor--Skin............................. Heptane (n-heptane)..................... 500 Hnechloroethane--Skin............- 1 Hexachloronaphthalene--Skin... Hexane (n-hexane).... `eoo'"' 2-Hesanone......................... .............. ioo Hexone (Methyl Isobutyl ketone)............................................ sec-Hexy] acetate......................... too so Hydraslne--rSktn.................... . 1 Hydnwm bromide........- 3 C Hydrogen chloride..................... Hydrogen cyanide--Skin............. 5 10 Hydrogen peroxide (90%)............ Hydrogen jeleolde..................... H ydroqi linone........................... . 1 a os ....... C Iodin ......................... ................... Iron ox'4 lurae.............. Isoam' l acetate................................ Isoam I alcohol.................... Isobutyl acetate............................... Isobutyl alcohol............................... Isoynorone............... ........... ....... Isrpropyl acetate............... Ixjpropy) alcohol............... 'ioo'"* too iso IOO 24 250 400 I jopropylamlne................................ ssopropylether.................................. Isopropyl glycldyl ether (IOE). Ketene............................................ B 9s0o0 as Lead arsenate................................... Lindane--Skin................................... Lithium hydride............................... L.P.G. (liquified petroleum t>................................................... 1,000 Magnesium oxide fume............... MaTathlon--Skin.............................. Maleic gnbydride............................ 025 C Manganese......................... Mesityl oxide.................................... Methanethlol, see Methyl mercaptan............................... .. Methorychlor..................................... 3-Methoxyethaool. see Methyl celteoive......................................... Methyl acetate................................. 200 Methyl acetylene (propyne)____ L 000 L000Methyl ecstylene-propadiene mixture (MAPP)........................ Methyl acrylate--Skin................... 10 Methylal (dimethotymethane).. 1.000 Methyl alcohol (methanol)...... 200 Methylamlne.............................. .. 10 Methyl amyl alcohol, see Methyl Isobutyl catblnol..,... 740 540 1,400 ICC 1,900 18 130 434 890 230 2,400 1,200 300 25 850 16 25 94 16 1 2.5 aa 6,400 209 200 iso 00..56 2,000 100 2 1,800 410 410 300 1.3 10 7 11 1.4 a2 2 1 10 626 340 700 300 140 950 980 12 2,100 240 aais as 0 025 1,800 15 15 10610 410 1.440 1,800 34 3,100 200 12 Substance p.p.m.* mg./M' * Methyl (n-amyl) ketone (2- Heptanone)................................... C Methyl bromide--Skin............. Methyl butyl ketone, see 2- 100 20 Methyl cellosolve--Bkin............... Metlivl celloaolve acetate--Skin Methyl chloroform.......................... Mcthylrydohexnne......................... Mcthylcyclohexanol....................... o-Methylcyclohexanone--Skin.. Methyl ethyl ketone (MEK), $ee 2Dutanon#*............................ Methyl foimate................................ Methyl todlde-- Skin...................... Methyl Isobutyl carblnol--Skin. Methyl Ltotmtyl Ketone, 25 24 340 500 100 IOO IOO 6 34 Methyl Isocyanate--Skin............. C Methyl mercaptan-.............. .. Methyl methacrylate.......... .. Methyl propyl ketone, see 2- 003 10 100 C " Methyl styrene........................ C Methylene bisphenyl i-oryanate (MDI)..................... Molybdenum: 100 003 Soluble compounds.............. Insoluble compounds............ .. Monomethyl aniline--Skin.... C Monomethyl hydrarine-- Skin............................................... MotphoWna--Shin......................... Naphtha (coeltar)........................ Naphthalene................................... Nickel carbonyl............................. 03 12090 1O0 OOI Nickel, metal and soluble cntpds, as Ni............................... Nicotine--Skin............................... Nitric add..................................... .. Nitric oxide..................................... 24 p-NttroanlUne--Skin................... 1 Nitrobenzene --Skin..................... S'NUrochlorobenxene--Skin... Uroethane........................... 1 100 Nitrogen dioxide........................... 6 Nitrogen trifluorlde...................... 10 Nitroglycerin--Skin.................... 02 Nltromethane................................ 100 1-Nitropropane.............. ........... 25 2-Nltropropano.............................. 26 Nitrotoluene-- Skin...................... 4 Nliroirlchloromethane, see Chlorr.plcrin............................... Ortai'hloronaphihalcne--Skin. Octane............................................ 600 Oil mist, mineral........................ Osmium tctroxlde______ ..... Oxalic acid....................................... Oxygen dlfluoride........................ 006 Ozone. 01 Paranuat --Skin............................. Paratnion--Skin..................................................... Pentabornne...................................... OOOS Peiuachloronaphthalene--Skin......................... Pen tachlorophenol--Skin.................................. .. Pentane............................................ 1.000 2-PenUnone...................................... 200 Perehloromethyl mercaptan___ O1 PercHtexyt fluoride....... ................. a Petroleum distillates (naphtha). 800 Phenol--Skin.................................... 6 p-Phrnylene dlamln*--Skin............................... Pbenyl ether (vapor).................... 1 Phenyl ether-biphenyl mixture (vapor)........................... 1 pheuyletliylene. see Styrene.............................. Phenyl glycldyl ether (POE)... 10 Phenylhytlrotine--Skin............... 5 Phnjdrin (Mcvinphos )-- Skin......................................................................... Phosgene (carbonyl chloride)... o1 Phosphine......................................... 03 Phosphoric acid.................................................. Phosphorus (yellow)......................... .. Phosphorus pentachloride.................................. Phosphorus pentasulftde..................... ............... Phosphorus trichloride................. O6 Phthallc anhydride........................ 2 Picric acid--Skin.......................... .... .............. Pival (2-PlvalyM.3- indandlone).......................................................... Platinum (Soluble Salts) as Ft............................................................................. Ptopargyl alcohol--Skin.............. 1 Propane............ ................................ 1.000 n-Propyl acetate...................................... 200 Propyl alcohol........................ 200 n-Ptopyl nitrate............................... 2S Propylene dichloride..................... 75 Propylene [mine--Skin................. 3 Propylene oxide............................... IOO Propyne. see Methylacatylene.......................... Pyrethrum.................. ......................................... .. Pyridine............................................. 4 Quinone.............................................. 0.1 RDX-Skln............................................................. 465 80 80 120 1.900 3,000 470 440 250 28 100 0.05 20 410 480 5 16 9 0.38 70 400 fiO0007 1 06 S 30 4 5 1 310 9 29 2 250 >0 00 30 2. 35in>. 1 5 li'. htr' 0. l 0.2 00.. 5I l 0.01 u.s 0. 5 2,950 700 08 \3.6 2,000 19 0.1 7 40 22 ai 0.4 0.4 1 0-1 1 1 132 0. I 0. 1 0 002 1,800 840 600 110 350 5 240 S IS 04 1.4 Substance p.p.m* mg./.MC ._______ ca_ Rhodium. Metal fume and N> dusts, as Rh..................................... Soluble salts...................................... Ronnel.................................................... Rotenone (commercial).................. .Pl 5-'"' Selenium compounds (as Se)........... Selenium hexafluoride.................. Sliver, -netal and soluble com pounds................................................ Sodium fluoroacctate (1080)-- 004 0*3 <fc* <rdi Skin..................................................... 0.04 Sodium hydroxide........................ 2 Stiblne...................................... .. Stoddard solvent........................ .. 0.1 600 0.5 2, 050 Strychnine............................................ Sultur dioxide................................... 6 Sulfur hexafluoride......................... 1,020 >uiruric odd..................................... .. Sulfur monochlorlde...................... I Sulfur pentafluoride....................... 0 026 0.16 13 4,000 1 a o.2S Sulfui yl fluoride.............................. S ystox. see Demeton ................ 6 20 -'.4.5T...................................................... Tantalum.............................................. If) 5 TFDP-Skln....................................... Tctluiium.......................................... .. Ti-llmium hexafluoride___ _____ 003 0.2 U. l 0. 2 TEPi'--Skin........................................ .... 0. 05 C Terphenyls.................................. 0 1.1.1.2-Tctracliloro-2,2HJlfluoroetliane............................ -......... .. 600 4,170 1.1.2.2-Tctracliloro-l,2-dlfluoro- ethane............................................. 500 4,170 V.l ,2,2-TetracUloroethane--Skin Tetrachloroethylene, see Per- 5 25 chloroethylene................................. Tetrachloromethane, see Carbon tetrachloride................................... . Tetrachioronaphthalene--Skin Tetraethyl lead (os Pb)--Skin... Tetrahydrofuran........................... 200 2 0.075 590 Tetcametayl lead (as Pb)-- Skin..................................................... 0. 07 Tctramethyl sucelnonltril^- Skln............................................... .. Te cronUrome thane......................... 06 1 3 8 Tetryl (2.4,6-trlnllrophenyl- methylnltramtne)-Skln............ . 1.5 Thallium (soluble comp. jnds)--Skin ns Tl.................... . 0.1 Tlilram.................................................. 6 Tin (Inorganic empds, except oxides.......................... ........... .. Tin (orgAntc empds)........................ (I Tolucne-2.4-dlisocyanat..... 002 2 0.1 0. 14 y-Toluldine--Skin.......................... 5 22 Tdxapliene, see Chlorinated cfiniphene........................................ . Til'iutyl phosphr.tc...................... . 1.1.1-Trich loroctl nine see Methyl chloroform......................... 1.1.2-Trlchlornethane-- Skin........ 45 Titnniun'dioxlde............ ................... 15 Ti iehloroniecliatie, see Chloro form....................................... ............. Triehloroiiaplithaleno--Skin........ . 5 1.2.3-TrirhloroRropatie.................. 300 1,1,2-Tilchloro 1,2,2-trtfluoro- ethatie............................................. Triethylamlne.................................. Tcifluotamoiiobrmnomeib&tve... 2,4.8-TrinitrophenoI, see Picric 1,000 25 t.QQO 7. C1O0O0 4,100 acid.................................... . 2.4.6-Trlnltroplienylniethyl- uitramlne. see Tetryl................. Trinitrotoluene--Skin.................... 1.5 Triorthocrcsyl phosphate.............. Triphenyl phosphate...................... Turpentine........................................ Urnniurn (soluble compounds).. Uranium (Insoluble compounds). 0.1 3 560 005 0.25 C Vanadium: V,Oj dust......................................... 0.5 ViOs funie........................................ 01 Vinyl benzene, sec Styrene______ *C Vinyl chloride.......................... 500 1,300 Vlnylcyanlde, see Acrylonitrile.. Vinyl tolucno.................................... Warfarin............................................... Xylene (xylol).................................. Xylidine--Skin................................ Yttrium..................................... .. Zinc chloride fume............... ........... ioo' ioo 6 480 at 42355 1 1 Zinc oxide fume......................... Zirconium compounds (aa 2r)... 6 5 1070 Addition. " Parts of vapor or gas per million parts of contami nated air by volume at 259 C. and 740 mm. Hg pressure.- Approximate milligrams of particulate per cublo meter of air. (No footnote "c" is used to avoid confusion with celling value notations.) An atmospheric concentration ol not more than 0.02 p.p.m., or personal protection may be necessary to avoid headache. 4 As sampled by method that does not collect vapor. < For control of general room alt, biologic monlioring Is csscuclol for penoanel control. XXV 8 9 fi$ m 0 0 0 OH 22142 TiBLX 0-2 RULES AND REGULATIONS Material 4-hour time weighted average AccepUbla calling concentration Acceptable maximum peak abort (he acceptable celling concentre- tlon (or an 8-hour shut. --------------------------------------------------"* Concentration Maximum duration Benxene (Z37.4-1969)........................................ lOp.p.m.............. 28 p.p.m... Beryllium and berylliumcompound* 2**g./M'....................6*g./M*.... (3137.29-1970). Cadmium fume (Z37.4-1970)........................... 0.1mg./M........... 3 mg./M'... Cadmium dust (Z37.S-1970)............................ 0.2rog./M'........... 0.6 mg./M'.. Carbon disulfide (Z37.3-196B)........................ 20 p.p.m................ 30 p.p.m... Carbon tetrachloride (Z37.17-1907)........ . lOp.p.m..............28 p.p.m... Ethylene dlbromlde (Z37.31-1070)................. 20 p.p.m.............. 30 p.p.m... Ethylene dlchlorlde (Z37.2I-1969)................. 60 p.p.m.............. 100p.p.m.. Formaldehyde (Z37.18-1967)........................... 3p.p.m................ 6p.p.m.... Hydrogen fluoride (Z37.24-1969)............................. do.................... ..................... Fluoride asdust (Z37.28-1989)........................ 2.8 mg./M................................... Lead and Its Inorganic com pound* (Z37.ll- 0.2 mg./M*................................... 1909). Methyl chloride (Z37.14-1909)......................... 100 p.p.m......... 200 p.p.m.... Methylene Chloride <237.3-1069)................... 600 p.p.m......... 1,000 p.p.m.. Organo (alkyl) mercury (Z37.3O-1960)..........0.01 mg./M *... O.Oi mgVM Styrene (Z37.15-19)....................................... 100 p.p.m......... 200 p.p.m____ Trichloroethylene (Z37.19-1987).............................. do........................do............. Tetrachloroetbyleae (Z37.22-1967)............-........ do........................do............. Toluene (Z37.13-1967)....................................... 300 p.p.m......... 300 p.p.m----Hydrogen suiflde (Z37.2-1906)..................................................... 20 p.p.m........ Mercury (Z37.8-1971)............................................................................ 1 mg./lOM . Chromic acid andchromatee (Z37.7-197I).............................................do*------- .. 60 p.p.m..............10 minute*. .. 26pg./M'.......... . 30minute*. .. 100 p.p.m............ Do. .. 200 p.p.m............ A minutes la any 4 hour*. .. 80 p.p.m..............6 minute*. ... 200 p.p.m....... 8 minute*Ln any 3 hour*. ... lOp.p.m......... 30minute*. .. JOOp.pjn............6 minute* In any 3 hour*. .. 2,000 p.p.m..... 6minutes In any 2 hour*. .. 600 p.p.m....... 8 minute* ln any 3 hours. .. 300 p.p.m............8 minutes In any 2 houn. ............. do............... 4 minutes In any 3 hours. ... 800 p.p.m............10 minute*. ... 80 p.p.m.............. 10 minute* onoe only U no other maasurable exposure occurs. Tablk 0-3--Miniral Dusts Substance MppcI* Mg/M' Silica: Crystalline: Qusrlt (respirable)......... 280* lOmg/M* %SlOr+6 Qunrti (total dust)......................................... Cristobnlite: Use H the vnlnc luUuluted from '.he count or mass formulae for quai 11 Trid>miio: l'se H the value cal, ulutcd from the for mula,, lor quartz. Amorphous. i.irtuding natural dlaioiii'i-.i'ous earth.................... 30 %SlOi+2 30mg/M' %8jO+-2 Bhng/M' %StOt Silimir.. (!'>. than 1% crys- tolliii.' Mii.'u): Mi, ........................................... Po.ai'-,<nii>................................... Tiiio tuon-esiiestos form) .. T!> .nhrous). Use asbestos limit .. .. Tri'iimiirr (see talc, librous) For 11 .i 11 -1 erment.................... Graphin' ;mi'uraP..................... Coal ilii'i lu-spirable fruition less ill an 8% SiOi).................. .. 30 20 20" 80 IS For more than 5^1 SiOj............ ....................... Inert nr Niueancc Oust: R*'M,ir;iMe fraction.................... Total dust.............................. 16 80 3.4mg/M: or lOmg/M1 %SIOi+2 Smg/M1 iSmg/M1 Aerodynamic diameter (unit doiulty sphere) Percent passing elector 2 00 2.5 78 3.8 80 4.0 28 10 0 The measurements under this note refer to the use of an AEG Instrument. If the respirable fraction of ooal dust Is determined with tMREuie figure corresponding to that o( 2.4 Mg/M] in the table tor coal dust U4.5Mg/MC NOTV Conversion f,vor -- mppcfX35 3 = million particle* per cubic meter >panicles per c.c. Million- of particles per cubic Tnot of air, based on Impmg-i samples counted !>v Injhl-field technics. ' The percentage of crvMalline silica in the formula Is the amount determined from alr-lmruc samples, ex cept in iho=c tn<taners in which other methods have been shown to ! applicable. i As determined liv ilic membrane filter method 31 430Xpha<e rornn^t ln:tgiiifn-:ilton. llOlh concentration .in,l percent quartz for the appli cation of tii h hm i l me in i,,, -I,-ter mined from the fi action passing ft sizc-selertor svilit the following characteristics: Containing < 1% ijuunr: if > 1% quartz, use quart* limit. XXVI