Document vj6nG0K4z3LkOZamz7xQmR0E

HRR26 _ 323) 403 ARR - 322] DuPont 5990 `TRADE SECRET Study Title with OneH-9-G02e-4n7De6ar8y:aGiaoSvnuabRgceehprrSootnduiudccytTiionoxniRcaEitvtsayluations Volume 3 of 5 Laboratory Project ID: DuPont-5990 TEST GUIDELINES: U.S. EPA Health Effects Test Guidelines 'OPPTS 870.3100 (1998) AUTHOR: Susan A. MacKenzie, V.M.D., Ph.D., D.AB.T. STUDY COMPLETED ON: January 18, 2002 PERFORMING LABORATORY: HE.aLskdelulPLoanbtodreatNoerymofuorrsHeaanltdhCaonmdpEannvyironmental Sciences || NElekwtaornk,RoDaedl,aPw.aOr.e B1o9x71540-0050 CompanySaritized. Does not contain TSCA GBI H9-02-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 APPENDIX G INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS -- BE -- Company Sanitized. Does not contain TSCA CBI H-24768: Subehronic 90.Day Gavage Study TinoxRiactistywith One-Generation Reproductive Evaluations DuPon5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS BASELINE AnNiummbaelr FORELIMBGRIP STRENGTH (kg) Trial] Tral2 Trial3 MTeraianlosf 'HINDLIMB GRIPSTRENGTH(ke) Trial] Trial? Teal MTeraianlosf Group I: 0 mykg/day 6371 047 46308 048 055 03 0a 04 049 042 c666s4161 005540 005&02 00152 00572 G62 063 646446 047 06 060 068 OSI 067 033 664s) i660 076 063 056 054 031 047 054 035 Gaods7 025 Gods 059 036 061 004676 00366 040 02 041 ox 03 023 038 0% 00337 oa 024 031 04 036 03s 042 025 03 029 030 025 036 026 029 02 0m 04 0 036 03 083 002366 00320 0023% 00235 Group I: 25 mkglday --_ 6646637909 005694 00446 005517 0ST 052 02 03% 03 031 0s 03 03 ox 664d 048 G6n2l 065 076 055 055 081 060 069 03% 0x2 03% oo 03 oo 0 0 6623 6626 029 056 053 053 08 040 047 050 03% 022 02 0: 03 02 0% 03s G63 057 Giisi 053 066 049 057 0&2 060 048 03 031 03% 03% 02 03 036 03s 6s66a4781 004570 005326 006520 O05I5 00238 0032 0o3x 0023 Group V: 100 m/kg/day e639 667 035 052 038 061 Os 050 04l 0s 646385 663s 056 048 0sl 060 037 070 048 059 cdots 0&2 GdGds6 OSI 061 065 061 048 06l 055 Gid66d6603 004225 003556 005278 005320 Gbiioas 005630 0065s2 00660 005589 0x 023 02 02 02 02 0 02 03 041 03 03 on ox ox 0 0x 031 oa oa 03 025 0 0 00148 0o%m 0022 019 03 002350 00330% 00236 002390 ona Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One- Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS BASELINE FORELIMBGRIPSTRENGTH(ke) NAnuimmbaelr Trial] Trisl2 Teald MTeeaansof HINGRDIPLSTRIENGMTH(Bse) Teall Teal? Trsl3 MeTarinalosf Group VI: 500 m/kg/day G67 03 035 0&2 043 G66 066 063 056 061 6s6e36m9 005786 007653 004SI6 00566 Gicws 042 061 064 056 64697 061 053 058 057 6628 054 055 056 055 66448 058 066 054 059 G64 032 041 044 039 Gio 024 038 065 042 021 oa 02 ox: 025 0% 0% 02 003287 004%6 0033% 00430 024 03 0% 02 041 036 02 036 030 02 0x ox 026 02 0% 0x 027 0m 0: 03 03 on 0% ox -es ____ `CompanySanitized. Doesnot contain TSCA CBI H902-4D7a6y8:GavSaubgeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS WEEK 13 AnNoimmbaelr 'FORELIMB GRIP STRENGTH (ke) Trial] _Trial2 Trial MTerainaosf HINGRDIPLSTRIENGMTH(Bke) Teall Tesl2 Triad MTeraianlosf Group 1:0 mg/day Ge 16 Le 1 Les Gis 106 Lie Ll Ll Geil 203 220 203 212 Gods 136 126 146 136 GGi66d2s 113530 1La2l3 113290 113318 66s) 16 103 La 137 G60 187 178 19% 187 G68 143 190 134 156 Geiod 158 Lad ld6 LSI 075 09 0m om 07 os 07 07 06 081 125 0% 058 06 075 06s 008836 o0s6s8 0087%6 00786 079 0% 081 086 oR 19 100 100 088 103 094 095 0% Loz 08 091 Group II: 25 my/keday C670 187 Le 135 146 053 om os 06 --~ G09 173 L819 172 051 06 081 065 asta Lal 206 10 172 076 066 064 06 66662213 L1e25t 0L9al5 117380 114380 005814 00s7t5 007708 005m8 6626 149 134 120 134 013 068 0m: om G63 107 02 138 Li 088 070 081 0% Gasisa 1s6 123 127 13s 071 0s 06s 074 Gaoiss 136 120 09% Lig 0% 107 oss 097 G61 Ll 082 097 098 oss 08 0% 077 Group V: 100 mg/kg/day G69 123 1 143 Ld6 663 1s3 195 130 183 Gigs La Ls Lo 1% G6i66i3ss LLas181108 007770 112087 Giciss Les 188 12 179 66463 LOL 13 131 LIS G66) Ls3 ss 10 L170 G6 125 083 097 102 Giciss 087 081 124 097 ose 037 052 048 084 087 088 086 053 100 080 078 00962 00%7 0060 006m8 ost 0% los 0% 051 066 061 059 081 08 08 084 052 057 067 059 076 086 081 081 ote `Company Sanitized. Doesnot contain TSCA C81 9102D47a6y8:GavSaugbcehSrtoundiyc TinoxRicaittsyvith One-Generation Reproductive Evaluations Dupont59%0 i INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS WEEK 13 EORELIMPGRIPSTRENGTH(kg) ANnoimmbaelr Trsll Trsl2 Tral3 MTeraianlsof HINGDRIPLSTRIENGMTH (Rkg) Teal Tes? Trad MTeeaankof Group VI: 00 my/keday GGis6: 01375 013 0la%s L12o0 sGoira 00132 013%% 0147 012a1 GGi6s7s 01955% 110s0 01681 1ll38a iGoiuss 1le2s6 210015 0ld%o 1Ll9 Gsiiooansss 012%9 01%4 012%8 111053 0osst oossss 0osm 006s o05m% o03m% 0o5m4 o03n6 0o9s1t o10n9 003s0 009 0076 oosmt 0oss oosms o0sss o0m7 00m% 00m% -_-- Company Sanitized. Doesnotcontain TSCA CBI 910.2.4D7a6y8:GavSaugbeoSntuidcy TinoxRiactistywith One-Genersion Reproducive Evaluations Dupont5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS --- mcovey Animal FORELIMBGRIPSTRENGTHM(ekagn)of Number Trial] Trial?Teald Tess Group 1:0 meeiday 'HIGN RID PSTLREI NGTMHM(eB ksgn)of Teall Trl? Teiald Teas GGe6m8 o1s7s0 o14m0 112216 L1a0s0 csinde 212%8 21025 2125 212ms sGii6ues 1L7D9 LLss61L0013Le iGsiios 119074 11556% L1iss 11205 GGoisas 11st710L6a o1m4 1a3z0 Group VI: 500 mgrkgday o0s6t o06s1s oosss o07ms 01076 013%0 0o%s oLsn 002 006ss o06ms 0o7s0 010%7 00876 00%% o09ms 0o8m5 0075 oossms oosss Gy Le 1s Le 1s 0s os os os - i646e364 015219 01143 00948 sn 181 Les ls 014173 1m 008s7 os 0o06ms5 00o.58s6ss o0o6rm9s GGi6o L1d8 L1l6 L1e9s 112m1 002s o0sn 008m5 ooses GGioousas 115258 115%1 110374 11m3 00871 01507 006%6 0o6ns Giionsa 01266 11184 010%s 019410 o05s5 o0ms oomm ooee - ws Company Sanitized. Does not contain TSCA CBI 9H0.2-4D7a6y8:GavSaubgeehSrotnuidcy iTnoxRiactistywith One. Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS BASELINE FORELIMBGRIPSTRENGTH(ke) Animal Number _ Trial Trisl2 _Tral3 MeTarinalosf 'HIGNRIDPSTLREINGTMH(Bke) Teall Tral2 Tral3 MTeeaanlof Group II: 0 mg/kg/day sGeSIs 004477 007661 005716 00s676 sdessi 058 c6s6s 028 072 053 006618 006560 cd6s80 059 Gd6ss1 025 0&2 034 043 041 0a 033 46586 035 66613 046 04s 058 04s 013 02 059 e627 052 s66s2 047 051 03 005a9 0o5m4 Group IV: 25 mg/kg/day 0033 03 035 0st 036 03 036 00&32 oodes 0oi3s o0a3 030 02 03% 02 03 02 03 025 023 034 02 020 023 03 02 02 002%6 00255 002% 003 cies 02 sa6s2 024 058 047 oe 03 057 03% - 6664566577 005580 006640 061 064 060 06] 64695 048 so 046 056 059 036 068 047 038 G63 049 66660 025 068 060 080 034 066 040 osdio6e6s3s 006518 0046s 004736 007419 Group VI: 100 mg/kg/day 024 0x 02 03 om oa om 03 ox 03 om 02 027 03 031 ox 031 041 03% 03 02 03 03 036 02 03 03 0x 03 03 0% 0 o0s2e7 03 050 03 05 om 051 66501 0s6 646505 054 058 064 00881 005676 646510 044 e634 050 053 082 046 085 048 om 64655 056 s6s78 057 055 052 053 054 055 054 coos 047 G64 039 054 034 061 03% 054 0a 646629 061 6663 055 040 0&2 0o6s4s 005558 004x7 o05m0 o0x2 00am 031 035 03s 041 03% 034 034 ox 03 020 03 03% 0% 02 0 0x 03 02 020 020 02 ox ox 0x 00231 0023s 0032 00321% on`Company Sanitized. Does not contain TSCA CBI H9-02D47a6y8;GavSaugbcehSrtoundiyc iTnoxRiactistywithOne.Generation Reproductive Evaluations DuPont 5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS BASELINE EORELIMBGRIP STRENGTH (kg) AnNiummbaelr Teall Tril2 Taal MTeraianlosf Group VII: 500 mpkg/day 'HIGNRIDP STLREINGTMH (Bkg) Trill Trsl2 Trial MTeeaankof s666s50068 00s610 00661 005471 006528 Gce6s4 00320 004667 O0S4I1 0o4d3s sGieessiass 004676 005658 005590 006s1t GGi5eo9ls 00337 0023 005613 004476 Gc6o6s 00564 005m0 003666 008%4 0033 003B% 0os3s o0%n 004234 00331 00228 003x 00443 003s 0033 ooxa 00238 003215 0032 0032 002s8 0032% 00336 0oxx _-- "a0: `Company Sanitized.Doesnotcontain TSCA CBI 9H02-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywith One. Generation Reproductive Evaluations DuPont:5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS WEEK 13 EORELIMBGRIPSTRENGTH(ke) HINGRDIPLSTRIENGMTH(Bke) NAnuimmbaelr Triall Trial? Trial3 MTerainaosf Teall Teal? Trad Mean of Trials Group It: 0 mg/kg/day ses ses 1 133 01363 o1m2 oLoile c6ssl Gd6s6s 077 087 0sL 136 127 080 09s 101 6c4e6s58s0 008717 004817 017285 00695% sess G63 Lo 077 08 105 012 148 099 Lio scdd66r2 110166 01265 01265 017282 Group IV: 25 mykglday 006877 oomm 0o6m6 0o6ms 0% 088 os 07 09s 07 09 080 0os4t0 004487 03 0s 0a 050 058 073 077 06 064 06s 066 06 00660 00668 06 067 066 06 ~ sGe6s2 01371 009%1 008956 o1s0s3 006714 o0s5t% 0os6l 0o6e6 646567 66576 086 099 090 126 080 106 085 Lio 06 070 0s 07 0x2 06 oss 0m 66662915 015246 016170 0l6ols 008868 00569 0076m 04 06 058 06 steels o660 148 08s 018245 019075 0192l3 00469 004m7 0064 00741 cdesss 646673 081 138 077 LIZ 066 095 075 11s 059 06 06 0&2 06 os 06 063 Group VI: 100 my/keday G6501 s6s0s 140 10s 134 LSI Las 102 140 Lio 666655130 11423 019386 012%8 L1o3o6 646556 64678 163 116 134 093 Lad Lis La 108 C608 6624 Ll0 079 140 076 120 0&2 123 066 666662393 113049 L1I2Z6 0160s5 1Lo1t7 071 om 08 08 0s om 080 076 00489 00623 068 om 060 08 051 042 06 041 0% 054 oss 046 048 059 061 07 056 061 055 066 004584 005s% o05a7 00530 _-- wr eee `Company Sanitized. Doesnot contain TSCA CBI H-24768: Subchronic Toricity 2109:0-DDaayGGaavvaageSSttuuddyyiinRRaattswwithOOnnee-GGeenneerraattiioonnReproductive Evaluaattiioonnss DDuuPPonmt:5599990. INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FORFEMALE RATS. _-- wWEe EK n 13 EORELIMBGRIPSTRENGTH(ke) HINGRDIPLSTRIENGMTH(Bkg) NAunNmuimmbbaeelr TTraollll TrTiriaall2 TTrraiall33 MTeiTarsinaossf TrTriialll] TeTiaall2' TrTirsal33 MTTreriaianlosf Group VII: 500 me/keday sess c6s08 12 105 117 093 om 101 100 100 GGe6s4 00663s 006584 006s9 006613 Gd6ss e688 12 101 128 087 13 125 131 104 6699 cols 131 06+ 120 073 085 086 Le 074 GGd6666s0 112010 L1o3l6 110027 112030 043 061 052 071 04 06 04 06s 006510 0o0664l 0054 005587 06 osl os oss 07m 060 07s 056 052 060 041 055 os os 0s 059 006716 094 066 073 065 081 064 _-- A -s Company Sanitized. Donotecontsain TSCA Cal 9H0L2-4D7a6y8:GavSaugbcehSrtoundiyc TinoxRiactistywith Oe-Generation Reproductive Exaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB FOR FEMALE GRIP RATS STRENGTH ASSESSMENTS -_ RReEcCOVVERRYY FORELIMBGRIPSTRENGTH(ke) ANnNuuimmmbaelr TTreoallll TTrrsli?2 TaTrlisl33 TMrTeriaiaanlosf 'HIGNRIDP STLREINGTMH(Bke) TrTriiallll TrTeiaall?? TrTriiaall3 TMrTeiraianalsof Group I: 0 my/ke/day G6466419 0L6U8 018239 110s6 018:6 6651 646565 Les 097 1L0861o6s lag 096 646580 6681 046 100 071 07 046 10s 054 092 66586 66613 066 109 090 135 119 Liz 09 Lio 646627 646652 045 Lol 06 Let 090 129 066 1s Group VIII: 500 mykg/day 0078159 00sst om 061 om 0m 087 067 088 on lo 06 092 068 066 067 068 063 066 06s 066 06s o6l 077 066 ost 0s on 06 oa 061 07 07 om 06s om 067 om --_ 6666550086 018052 00967 015153 009783 00453 00:m2 oosss 00570 siesa0' 64652 038 081 03% 081 035 076 03s 079 059 074 0s 064 06 060 oe 066 6Gd66sd8s 1L0I7 113044 01830 019296 6699 060 082 089 077 005788 00771 07 052 om 060 051 050 047 os 66618 646637 076 09 007799 008&52 00878 006496 005706 003660 004683 646650 146 120 L100 126 06 0% 013 om es *Rasttat6istica4l ewvaa6lsuuant5cioonop4erat0ive during forelimb grip strength. Data were not included in the group meoatnhe 6 Company Sanitized. Doss not contain TSCA Cal H.24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX H INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS wo `Company Sanitized. Does not contain TSCA CBI 9102-4D7a6y8:GvSuabgeehrSotnuidcy TinoxRiacittywithOne-Generation Reproductive Evaluations DuPont 5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS EXPLANATORY NOTES INDIVIDUAL FUNCTIONALOBSERVATIONALBATTERY SCORINGSYSTEM MANIINOPPENUFIELLD ARA ENA(TFREI E ROAOMINN GSPASCE) APPROACH &TOUCH: "0t== roomraadion 1 increasedreaction Gumsawayor tacks) AUDITORYSTIMULUS: d == proomraadlireoancion atfincheso fickscar) |Z exagsgcieonr(rtajumtps.epde) TAIL PINCH 0 == nporsopounrsmesmwaardslic) 1 = caspgeracd response (vocalizations, rapid wing) INMOTORACTIVITYMONITOR PUPILLARY RESPONSE: -- DEFECATION: URINATION: Abbreviation: ~ NoDau Collected 0|e= pdreesen 0Io= apbrseesnetn DZ Game 0Ta= spreesnen EE Company Sanitized.DoesnotconTtSaCAiC8n1 H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats withOne-GenerationReproduciiveEvaluations DuPon-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS GrouIp: 0 my/kg/day Manipulation TnMotorActivity Animal Approach Auditory Pupilary NumberTimePoint and Touch Stimulus Tail Pinch _ Response _Defecation_ Urination 646371 Baseline 0 0 [3 0 1 0 ReWceoevker13y 00 00 03 00 11 11 646398 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 646411 WBaeseeklin1e3 00 00 00 00 01 0' Recovery 0 0 0 0 0 1 646416 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 0 0 Recovery 0 0 0 0 0 1 646432 Baseline 0 0 0 0 0 0 - Week 13 0 0 0 0 ' 1 Recovery 0 0 0 0 0 1 646446 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 1 1 Recovery o 0 0 0 0 1 646459 WBaeseeklin1e3 00 00 00 00 01 01 Recovery 0 0 o 0 0 1 646460 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 646487 WeBaeseklin1e3 00 00 00 00 01 11 Recovery 0 0 0 0 ' 1 646494 Baseline 0 0 0 0 0 0 Week 13 0 0 0 0 1 1 Recovery 0 0 0 0 ' 1 "e2- -- Company Sanitzed.Dossnot contain TSCA C81 F9-02-4D7a6y8:GavSaugbcehSrtoundiyc TinoxRiactistywith One Generation Reproductive Evaluations DuPont5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS Group Il: 25 mkgiday `Manipulation in Motor Activity ANnuimmbaelr Time Point__aAnpdprTooaucchh A_uSduimtuolruys _Tail Pinch_RPeusppilolnrsye _Defecation_ Urination 646370 Baseline 0 0 0 0 1 1 Week 13 3 0 ' 0 0 1 646399 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 1 1 646414 WBaeseeklin1e3 00 00 00 00 00 11 646421 Baseline 0 0 0 0 ' 1 Week 13 0 0 ' 0 0 1 646423 Baseline 0 0 [3 0 0 0 Week 13 0 1 0 0 ! 1 646426 Baseline * 0 0 0 0 --- Week 13 3 0 3 0 0 0 646443 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 1 1 6a6asa Baseline 0 0 0 0 0 1 Week 13 0 0 3 0 1 1 Ga64s8 Baseline 0 0 0 0 [3 1 Week 13 0 0 0 0 1 1 646471 Baseline 0 0 0 0 1 1 Week 13 0 0 ' 0 0 1 - * Defecation and urinationwere not recorded. Company Sanitized. Doesnotcontain TSCA CBI 910.2-4D7a6y8:GaSvuabgeehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS GrouVp:100 mg/kg/day. Maripulation In Motor Activity ANnuimmbaelr TimePoint anApdprTooaucchh A_Sutdiimtoolruys Tail Pinch _pRuepsiplloanrsye _Defecation_ Urination 646349 WBaeseeklin1e3 0 0 0 0 0 0 0 0 0 0 0 ' 646373 WBaeseekli1n3e * 00 [33 00 00 01 11 646385 WBaeseeklin1e3 0 0 0 0 ' 1 0 0 0 1 1 1 646435 WBaeseekliln3e b 0 0 0 0 0 0 0 0 1 1 1 1 646455 WBaeseekliln3e * 0 0 0 0 0 0 0 0 0 0 ' 0 646456 WBaeseeklin1e3 0 0 0 0 0 0 0 0 1 1 1 1 - 646463 WBaeseeklinIe3 0 0 0 0 0 0 0 0 0 1 1 ' 646469 WBaeseeklinIe3 0 0 0 0 0 0 0 0 1 0 1 1 646472 WBaeseeklin1e3 0 0 0 0 0 0 0 0 0 0 1 1 646488 WBaeseeklin1e3 0 0 0 0 0 0 0 0 0 1 0 1 ~~ **SAobrneofromraelligmaibtf,ofelsa.ttened rea posture. `CompanySanitized. Doesnotcontain TSCA C81 9H02-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS GroupVII: 500 mg/kg/day `Manipulation In Motor Activity Animal Approach Auditory Pupilary NumberTimePoine and Touch Stimulus_TailPinch Response _Defecation_ Urination 646337 Baseline 00 0 0 0 1 Weekl3 2 0 a 0 0 1 1 Recovery 0 3 0 0 ' 1 646361 WBaeseeklin1e3 00 00 00 00 !1 11 Recovery 00 0 0 0 1 646369 Baseline 0 0 0 0 ' 1 Week13 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 646372 Baseline 0 0 0 0 1 1 Week 13 00 0 0 0 1 Recovery 0 0 0 0 ' 1 646384 Baseline 00 0 0 1 1 ao Weeki3 0 0 0 0 0 1 Recovery 00 0 0 0 ' 646397 WeBaeskeli1n3e 00 00 00 00 0' 11 Recovery. 0 0 0 0 o 1 646428 WBaeseeklin1e3 00 00 00 00 01 11 Recovery. 00 0 0 0 1 646445 Baseline 00 0 0 0 i Week I3 00 ' 0 1 1 Recovery 3 0 0 0 ' 1 646474 Baseline 0 0 0 0 ' 1 Week13 * 0 0 0 0 ' 1 Recovery 30 0 0 0 1 646484 Baseline 00 0 0 0 1 Week13 * 0 0 0 0 ' 1 Recovery 00 0 0 1 1 * Stained perineum, yellow. --_ "*SSoorreeflofrtelfiomrblitmobe.s. `Company Sanitized. Does not contain TSCA CBI 51024D7a6y8GavSaugcehSvtouidcy TinoRaitcstywithOne GenerationReproductive Evalutons Dupon5390 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS Cowlompgty --_-- Monipultion InMotorActiviy "ANnuimmbaelrTine Poin __a`nAdppTroouacchh__ ASuidimtuorly_ Tail Pinch _pRuepsiplloarrsye _ Defcon Urination saestn WBeueskin1e3 00 o 00 11 Reovey 0 o o 1 cies WeBaeskin1s3 o 00 o o 00 1 Reo 0 0 1 1 odes WeBacskin1s3 00 00 o 00 00 ': Reovy 0 o 1 : saeses WeBucskin1e3 00 00 oo 00 : Recovery 1 1 66580 Buscine 0 0 o 0 1 ' - WReeecokver1y3 0 00 0 0 01 1\ Gss1 WBeasksi1n3 00 00 00 00 01 ': Recovery o : 66586 WBeaseeklin1e3 00 00 00 o0 o1 i Recovery 0 : 66613 WBeaseeklin13e 00 0o 00 00 o' \' Recovery o o : 66627 WBaeseeklin13e 00 o0 00 00 o1 i: Recovery 0 0 1 66652 WBaeseeklin13e 00 o0 00 00 0' :: Recovery 0 0 ! EE Company Sanitized. Doesnotcontain TSCA CBI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproductive Evaluations DuPon-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FORFEMALE RATS GroupIV: 25 mg/day Manipulation Tn Motor Activity Animal Approach Auditory Pupilary Number TimePoint and Touch _ Stimulus_TailPinch_ Response _Defecation_ Urination 646502 Baseline 0 [3 0 0 0 0 Week I3 0 3 0 0 0 1 646522 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 1 1 646567 Baseline 0 0 0 0 1 0 Week 13 0 3 0 0 0 1 646576 Baseline 0 0 0 0 0 0 Week I3 0 0 0 0 1 1 646595 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 0 1 646621 WBaeseeklin1e3 00 00 00 00 01 1' 646635 Baseline 0 0 0 0 1 ' Week 13 0 0 o 0 0 1 646660 Baseline 0 0 0 [3 1 1 Week 13 3 0 0 0 1 1 646664 Baseline 0 0 0 0 ' 1 Week 13 0 0 0 3 ' 1 646673 WBaeseeklin1e3 00 00 30 00 01 11 - ee CompanySanitized.Doesnot conTtSaCAiCBnI 9H-02-4D7a6y8:GavSaugbcehSrtoundiyc TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS Group VI:100mykyiday `Manipulation Tn Motor Activity ANnuimmbaelr TimePoint __aAnpdprTooaucchh_ ASutdiimtuolruys_ Tail Pinch_ RPeusppiloanrsye _Defecation_ Urination 646501 WBaeseeklin1e3 0 0 0 0 0 3 0 0 0 1 1 1 646505 WBeaseeklin1e3 0 0 0 3 0 0 0 0 1 ! 0 1 646510 WBaeseeklin1e3 0 0 0 3 0 0 0 0 0 ' 1 1 646534 WBeaseeklin1e3 0 0 0 3 0 0 0 0 0 0 1 0 646556 WBaeseeklin1e3 0 0 0 0 0 0 0 0 ' 3 1 1 -- 646578 WBeaseeklin1e3 0 0 0 0 0 0 0 0 o 1 1 1 646608 WBaeseeklin1e3 0 0 0 0 0 0 0 0 0 1 0 1 646624 WBaeseeklin1e3 00 00 o0 00 01 11 646629 WeBaeskeli1n3e 0 0 0 0 0 0 0 0 0 0 1 1 646633 WBaeseeklin1e3 [33 00 00 00 01 11 - es `Company Sanitized. Donotecontsain TSCA CBI F-24768: Subehvonic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS. Group VIII: 500 mkgiday TT Mampuion InMolorAdiviy Animal Approach Auditory Pupilary Number TimePoint and Touch _Sumulus_ Tail Pinch _Response _Defecation_ Urination 646506 WBaeseeklin1e3 00 00 00 00 11 11 Recovery 0 0 0 3 1 1 646508 Baseline 0 0 0 0 0 0 Weeks 0 0 0 0 3 1 1 Recovery 0 0 0 0 1 1 646540 WBeaseeklin1e3 00 00 00 00 11 11 Recovery 0 0 0 0 0 1 646542 Baseline 0 0 1 0 0 0 Weeks +0 0 0 0 ' 1 Recovery 0 0 3 0 ' 1 - 646545 Baseline 0 0 0 0 0 1 Week13 * 0 0 0 0 0 1 Recovery 0 0 3 0 0 1 646545 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 0 1 Recovery 0 0 0 0 1 1 646599 Baseline 0 0 0 0 0 0 Week 13 0 0 0 0 0 1 Recovery 0 0 0 0 0 1 646618 WeBaeseklin1e3 00 00 00 00 01 11 Recovery 0 0 0 0 ' 1 646637 Baseline 0 0 0 0 0 ' Week13 * 0 0 0 0 ' 1 Recovery. 0 0 0 0 0 ' 646650 Baseline 0 0 0 0 0 1 Week13 * 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 * Stained perineum, yellow. _---- Company Sanitized. Doesnot conTtSaCAiCBnI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPon:-5990 APPENDIX I INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT To -- Company Sanitized. Does not contain TSCA CBI HL24768: Subelronic Toxicity 90-Day Gavage Study in Rats withOne.Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS BASELINE NAunimmbaelr SUCCESSIVE 10-MINUTE INTERVALS 1 2 3 4 5 s Toul Group: 0 mkg/day 646371 Ed 257 250 at 1 0 944 646398 2 268 20 181 58 25 0s 646411 385 305 288 1 0 0 106 664466443126 3626 22839 w9n3 2828 285 m5 ms780 646446 358 200 147 20 8 9 242 664466445690 3624 282116 116816 2201s4 25 02 w9o4n5 646487 348 m3 17 98 2 9 503 646494 06 30 261 8 1s 5 1000 Group Il: 25 me/kgiday 646370 2 260 26 149 124 [I - 646399 mn 20 181 as 0 @ 845 664466442114 a227 32798 2391 a63 10 1u 4 a726 646423 346 256 128 4 6 44 664466442463 3605 21369 210%5 2628 1292 25 s2s9 poroen a19 270 2 0 179 51 1321 6i658. 360 29 254 8 a 1 996 616471 3 253 3 30 1s 15 m Group V: 100 mg/kg/day. 66i466334793 646385 664466443555 646s 646463 646469 6po4r6e472 32071 amnn 216564 213s6 7865 0 24 22 7 8 m20n4 226 113808 72 27 an 359 a 6 a6 an 3% ue 253 173 393 wm is 2 336837 118512 nr0 o1 1a6 9' 193776 23 13 775615 2 592 3 sa 1 985 un' 5E5E5 - `Company Sanitized. Does not contain TSCA C81 H502.4D7a6y8:GavSaugbechSvtoundiy TinoxRiactistywith One Generation Reproductive Evaluations Duon-5990 INDIVIDUAL MOTOR ACTIVITYFAOSRSEMSASLMEENRTA:TSDURATION OF MOVEMENT (scc) BASELINE NAunmimbaelr Succesive 10-Minue Intervals 1 2 3 ` 5 Toa Group VII: 500 m/ke/day p6o46337 664166336792 p646e39n7 6c1t6604258 peeerer) waes mssw awmows100 5"0 w Bo os m 226% 12e 105 w ea as e al aasm oaw I os T)20 81 "0 16 0ma a0s 316 uo5 o2 none xoom0 83 nuem 25 sowe v5 owsoe --_-- Company Sanitized. Does not contain TSCA CBI 9102.0D7a6y8:GavSaugbeehSotrudiyc ToxRiacistyithOne Generation Reproductive Evalutions Dupont5950 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS WEEK 13 NAunmbaelr Successive 10 Minute Intervals 1 2 3 4 $ 6 Total Group: Omykgidey psir6298 asw eanws owmm awe mis0e lw e m16 asiosille ea0s w a zmwws azss 22a0 2u0sk sisosiio wws weam w3e0 mmee a14s aw s m19% paeirsoinsy0 wnss 6se 2u m m20 ds ssnole pseirio94 w0o oamw saes se a mms a6s anmu Group i: 25 mgrefday sm0 wom 6 ws wm a ow - s6o4c6ii3s9tl9s 3w 4M3 0o0m8247 m 39 05 a Bm 2ap0we3 12m 35 s1n41o0 ssiici wwo ommssomy masm o0m aass oaosm ssiisiiss aaro dass oamw w a0 mms 3m0 wiee peGriost aBosomm o0m omms oomm mwse mwmm Group V: 100 mefkgiday ssi6i34m9 ssiionss ssiiooiisss6 ssooss) ssioiiosns aMe m as esasl3 W sw mwom2s i sM0 omvs 2w 8 z20 wSes oam0 22s7 mas s so saan mw0e mwsy aosm l0s Dsod memmimsi aUe8 w1es lsaew aosss 9is ssse 2m%e wwem oaosm0 -- ee Company Saritized. Does not contain TSCA G81 H902-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS WEEK 13 NuAnmibmealr Successive 10-Minute Intervals 1 2 2 4 3 6 Toul Group VII: 500 mgkgiday s6i466333674 a2es mowos aomm o5m a20% s[ e am 64466337629 33861 3M6e 22620 2 28 m2m 22600 a9 66466335947 a3a2 2369 2de4s a20 836 383 2soas 44664042s8 auss o6w 21891 m vom ws 8wo 1l90e0 6646448744 s 1 wML 22s a0u2 3w5 om2811ssm ee Company Sanitzed. Does not contain TSCA CBI 9F-02-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS NuAnmibmealr RECOVERY Successive 10-Minue Intervals 1 2 3 4 H 6 Toul Group I: 0 mkgiday 646371 664466341915 664466441362 664d66445469 664466448670 646494 03 280 281 210 126 369 358 266 29 150 a3i8s4 231156 2m6 219s 21542 4 350 21 265 256 aEins 23376 3160 251550 18655 363 263 128 21 254 365 136 29 256 2 a3 310 304 En ES 00 150 us 17 aws aIsns 7 1s 2uz 0s 13 10 61 1951 Group VII: 500 mg/kg/day ~ 664466333671 a31 336584 22097 1E9a6 202834 x185 1ss s 664466336792 450 an 206 288 8 260 216 261 205 163 2 12 107 en 664466338947 22005 221m4 21299 1n9g3 21840 901 1035%1 664a66442488 31 209 206 300 219 1 ame rl 359 280 an x 30 196s 664466448744 a1 pn 24 300 273 206 195 25 29 By 17516314008 "on Company Sanitized. Doesnot contTSaCAiCnEI H24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS. NAunimmbaelr BASELINE Successive 10-Minute Intervals 1 2 3 4 5 6 Toul Group I: 0 mefkg/day sa6s11 646549 66551 664466558605 646581 664466651836 646627 646652 9 351 147 406 a9 3% 208 131 92 m 30 26 163 3s 10 336064 30274 20mn3 215307 nm6 381 295 27 276 9 330m7 22500 imst6 1940 1659 37 292 38 393 28 326 m2 192 74 19 99 2012 0 es 0 763 46 u1n6 8 0% 91a 172081s oan 98 101 Group IV: 25 mgkg/day. _ 646502 366 150 53 02 02 646522 324 7" 150 mn 0 2 90 664466556776 a7a 324017 amto 1519 7s5 20 s92s6 646595 318 178 90 36 152 2 795 646621 an 25 191 181 4 0 103 664466663650 a3041 25350 25080 32077 326103 n2 e m 1502 646664 343 301 263 267 31s 28 on 646673 3% 290 a 38 a sum Group VI: 100 my/ke/day 664466550015 336s7 2280 123087 110529 2531 or8 u120m8 646510 31 25 6s [3 7 0 670 664466553546 30116 3260 2261 218768 28&0 084 u1s0e0r6 646578 26 105 198 a3 1 612 646608 a8 320 286 304 269 ws 661466662249 20815 238209 2151 1a315 n2s [133 99305 646633 365 263 310 28 13 na as EE Company Sanitized. Does not contain TSCA CBI H9-02.4D7a6y8:GavSaugbcehSrtoundiyc TinoxRiactistywith One- Generation Reproductive Evaluations DuPont5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS NuAnmibmealr BASELINE `Successive 10-Minute Intervals 1 2 3 4 5 6 Tow Group VIII: 500 melkpday c6i466550086 aw20 11689 13"08 46| [T3E m 6p4r6e54s0 w dau u 015s7 3B8 ae6 or0 amss p6ri6esiys 2m m ow 173 w15m3 m2 1987 u & eos 6466656198 w37o1 2s6e8 126:6 3o5m 17n8 91s 1866566 664466663570 w a6 s3 2%0 3104s 203 0[I 166 es `Company Saniized. Doesnotcontain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study inRats withOneGeneration Reproductive Evaluations DuPont. 5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS WEEK 13 Animal Number Successive 10-Minute Intervals 1 2 3 4 H 6 Tou Group I: 0 mg/kg/day 4611 53 30s 273 203 3 a7 206 646549 a 304 127 25 255 Bis 664466555615 23701 203538 m31a4 m16n0 2213 on1007 646580 rl 266 29 20 155 2 ms 664466558816 6a47 313s0 32697 134s 2288 2938 s16i0s0 646613 362 305 Ed 202 23 7 se 664466665227 p3e% 22186 217s0 37049 1265 270 s10s6s0 Group IV: 25 mgkgfday --- 664466550222 363619 3 22 27 25 na 210 9 m nue 00 13 646567 46 30 2 22 285 28 ass 646576 358 336 281 260 22 99 1536 661466652915 46600 23825 116500 1273 2m 8162 u12s1 646635 38 EE 130 288 24 29 1496 664466666604 35528 262662 21 20 26 183 314 20 22 ue 162 646673 ass 27 251 27 198 040 152 GroupVI: 100 mg/kgiday 646501 664466550150 646534 646556 66446650788. 646624 646629 646633 83803 3621 1293 2250 22602 04 207 335 Ea am 357 159 208 275 73 an 39 27 26 303 9a13 am 207 74 a 381 100 343 20058 2011 1843 211925 2204 an 304 2 1 146 022s 11s6s1s 256 1998, 00 e12s95 185 ns a0 21 27 135% 20 1580 --- Company Sanitized. Doesnot conTtSaCAiCBnI 9H0-2-4D7a6y8:GavSaubgeehSrtoundiyc TinoxRiaciistywithOne-Generation Reproducive Evaluations DuPont5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS WEEK 13 NAnuimmbaelr Successive 10-Minute Intervals 1 2 3 4 H 6 Tow Group VIII: 500 mg/kg/day 664466550086 646540 664466558425 646548 646599 64466663178 646650 a375 32190 E35X7 2237 2769 8 36 28 28 185 186 106 166 119033 an 306 198 191 3 300 288 28 132 46 3 264 250 71568 as6s4 336501 2n6l0 2209 42803 32 264 2 30 21 Ho 0% 7s 21 2m5 us as mon 2985 11133% 253 Isao a 2040 96 11s RN.TMwtrri'irtrorar Company Sanitized. Doesnotcontain TSCA Cal H-24768: Subehronic Toxicity 90.Day Gavage Study in Rats withOne-Generation Reproductive Exaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS. RECOVERY NAunmibmaelr Successive 10-Minute Intervals 1 2 3 4 5 6 Tom Group I: 0 my/keday 664466551419 646551 646565 6446658810 66586 664466662173 646652 aan8 36836 302 218 10 a3 3a988 263577 346 257 626 3m801 364 258 239655 23801 261018 23501 2183066 284 20 201 00 1669 21 04 251 139 1668 312592 114802 235 2B6n 2 1538 24 182 o wo 3 3t38d 216318 1561 a2 i1ss 284 153 145 a on Group VIII: 500 mg/kg/day - 664466550086 3a11s 139088 212775 225 2213 22516 amn0 646540 as 26 26 266 155 2 6s 6i6532 an 185 168 176 204 13s 664466554485 o3031 327565 233561 201322 212s0 2o0s 1B8R97 646599 503 an 308 27 29 sor 664466661387 parn 335037 25229 36510 218212 00 1sns 646650 38 260 24 189 181 51 ns --- CompanySanitized. Doesnotcontain TSCA CBI 9H0-2-4D7a6y8:GavSaubgcehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 APPENDIX J INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS ee `Company Sanitized. Dossnot contain TSCA G81 9H0--2D47a6y8G:avSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont:5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS NAunmimbaelr 1 Group I: 0 mg/kg/day BASELINE Successive 10-Minute Intervals 2 3 4 s 6 Tow 646371 p6o46r398 646416 66446644342 646459 664466446807 646494 22 141 138 31 u 111306 112027 112s9 1251 360 1490 150 1490 148 13s 3140 11138 8038 1138 47 145 130 na 5 18 113555 1326 112083 24 33 129 Bl 146 n 5 1 as 210 539330 140 853 o4 431550 2 08 a5 5s0i0 7a Group IT: 25 mykglday 646370 -- 646399 661i66042114 646423 646426 664a66444534 6464s 6i6471 137 149 129 127 07 148 162 130 55 1 115385 115450 19019 56 76 167 141 110 5 5 135 134 58 6 2 114362 115374 114390 11534 112s0 152 132 147 50 2 137 1a rl 2 n 2 oa a 539 i3s aa1s 7 pr 8 405 316 92460 3 526 n mn Group V: 100 mgkg/day 664466337439 646385 664466443555 64656 646463 646469 664466448782 19256 112263 102 129 1B4l9 118532 108 107 133 13 2s 139 119s9 nu9 11007 112003 783 53 62 110588 668 2n 31 4 18 150 127 146 134 25 3 [83 a83 34 33 552548 5 37 27 asi63 2 280 s 74 4 450 n3 2a2n -- --ew Company Sanitized. Doss notcontainTSCA C8l H9-02.4D7a6y8G:avSaugbcehSrtoundiyc iTnoxRiactistywith Ore-Generaton Reproductive Evaluations DuPont. 5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS BASELINE NAunmibmaelr Successive 10-Minute Intervals 1 2 3 4 5 6 Tou Group VII: 500 mg/kg/day 646337 i636 664466337629 646384 664466432987 porary pre 646484 51 129 13 5 9% nm 133 109 & 11321s 113362 134 2 9 In "1 189 133 24 32 us o1152 12598 58 2 3 3 5 132 13s 16 is 13 m 133 1 3 3 151 13s El I 2 6 a7 a 527 | 503 25 36654 3 21 67 32634 3 10 9 362 ee Company Sanitized. Does not contain TSCA CBI H-24768: Subehronic Toxicity `90-Day Gavage Studyi Rats withOneGeneration Reproductive Evaluations DuPont5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS WEEK 13 Animal Number Successive 10-Minute Intervals 1 2 3 4 3 6 Toul Group I: 0 mekgiday 646371 646398 646411 664466443126 66446 664466445690 646487 646494 197 135 151 132 124 134 149 108 0 % 31 153 128 122 143 12319 112355 112590 115012 22 nr 120 16 128 8 112392 61457 m1 172s3 1337 13 125 90 07 no m 2 130 14s ns 102 1 70 43 108 75 113374 755043 34 59 221 376s9 8 653 145 768 Group Il: 25 mghkg/day pe 664466337909 11572 114337 12274 n8o1 113013 12078 o76s5 646414 139 146 151 6 157 na 7m 646421 120 136 152 95 nm 23 763 664466042236 m1n42 1138s 1135s 12543 2n3s 91534 77283 646443 146 166 17 146 132 1a 78 6465s 126 130 18 126 144 108 7% 664466445781. 2192 112693 19389 112508 nuss 19613 85241 Group V: 100 mgkg/day 646349 12s 121 27 16 no 82 0 646373 148 147 109 103 130 103 40 664466433855 118406 119823 122s 226 1393 147"4 485168 oasis 159 1 138 148 109 us, 93 646456 21 140 24 07 12 nr mm 664466446693 11380 112317 9 126 58 104 130 126 7 2% 106 733 46472 108 32 146 119 126 5 719 6asa8s 126 136 155 138 168 134 857 --- `Company Sanitized. Does not contain TSCA GBI F9-02-0D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS WEEK 13 NuAnmibmealr Successive10:Minute Intervals 1 2 3 4 H 6 Toul Group VII: 500 mg/kg/day 646337 646364 664466337629 646384 664466432987 6d6ads 646474 46484 138 17 in 1a 2 105 12212 1332 114481 182 135 124 15637 15C5d 95%2 126 140 31 19 128 126 151 136 136 105 106 9 on 32 119 3 705 n9o 112s7 113360 7m52 mn 12 126 760 6116 2519 75% 63415 2 109 101 7 14a nr 126 760 155 106 162 846 ER `Company Sanitized. Doas not contain TSCA CBI H9-02-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywith OneGeneration Reproductive Evaluations DuPoni-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS RECOVERY NAunmibmaelr Successive 10-Minute Intervals 1 2 3 4 5 6 Tom Group: 0 mg/kg/day 46371 646398 664466441116 646432 664466444569 646460 664466448974 140 156 192 145 138 129 1man1 1227s 11429 148. 139 137 n1m6 113562 110318 129 128 9% 11B81 1256 11348 135 103 2 798 125 21 149 807 14865 92% n8m m654 14 139 127 3 110386 Ia81 159 6&1s8 10 nm 8 659 n15s7 1517s 1465 5E0Y0 Group VII: 500 mg/kg/day 646337 646364 664466336792 646384 646397 664466442488 646474 6i6181 125 134 5 7 ns 120 662 nm us a 133 86 568 21598 114545 11523 115012 1n0m8 1204 77%9 109 7 ut 8 7 7 506 134 BI 133 135 127 128 788 1223s 113268 1109 112372 110404 1059 570545 120 13 128 104 31 9 719 32 8 3 % 2 4 an Company Sanitized. Doas not contain TSCA CBI H24768: Subehronic Toxicity 90-Day Gavage Study in Rats withOne.Generation Reproductive Evaluations DuPon-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS NAunmibmaelr 1 Group I: 0 me/kesday BASELINE `Successive 10:Minute Intervals 2 3 4 3 6 Toul 64611 664466555419 646565 664466558810 646586 646613 664466662572 53 2 61 53 116s0. 113034 13895 3o8l 13n6 125 126 151 120 9 114139 11697 19424 1120s9 1700 129 13 50 0 7 17 158 124 192 2 113501 11316s 112240 1n35s i3o5 2 20 62 S8635 5 536 562 E4ns 9 38 133 816 2 75567 Group IV: 25 my/kg/day 646502 143 2 50 '2 03 -- 664466552627 2242 15511 17294 onml 1331 65 62417 646576 137 134 1s 20 a 2 41s 664466652915 113034 11202 10I2a 1320 1014 35 4as9s6 646635 130 130 108 128 151 104 751 646660 ig 119 16 141 107 25 as 646664 136 130 136 128 i 151 0 646673 us, 138 2 102 2 6a Group VI: 100 me/kday 46501 123 125 130 10 40 7 535 664466551005 11a37 112370 1650 I13n8 1399 055 373909 646534 137 125 10 130 71 9 on 646556 128 128 125 2 153 a 663 664466567088 13018 087 110353 1014 u3a7 02 0074 646624 139 138 124 9 2 5 529 646629 109 nm i ns 9 21 531 646633 131 m2 135 106 121 6 669 --- Company Sanitized. Does not contain TSCA CBI 9H0-2-4D7a6y8:GavSaugbehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS. Animal Number 1 Group VII: 500 mg/kg/day BASELINE Successive10:Minute Intervals 2 3 4 H 6 Tou 664466550068 1123s2 21540 u23 376" 4 255 aas 646540 646582 154 14s na 119 149 104 785 144 150 in 31 10 2 ast 646545 646548 144 1a 143 7 us 51 7m 134 Lo 16 3 6 19 578 664466569198 11403 1120s8 i13n2 129 1I0s6 736 a6531 664466663570 120 138 108 104 1 148 146 7 a 0 2 s01 o an -= Company Sanitized. Does not contain TSCA CBI H24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont. 5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS. NAunmibmaelr 1 Group I: 0 mg/kg/day WEEK 13 Successive 10-Minute Intervals 2 3 4 5 6 Tou 646511 664466555419 664466558605 646581 646586 664466661231 646652 82 8 7 o1 n 7 476 112249 114024 1847 31416 12319 193%7 "817 67 2825 110416 1938 n95a 33 s1is 133 146 150 07 149 16 61 123 123 103 3 139 uw 618 115s0 1761 1956 12537 15100 133 68827 1a1 27 135 126 m3 124 766 Group IV: 25 my/kgiday 646502 134 1483 147 3 2 as 3 --- 664466552627 1338 112390 o12t3 12032 n13a3 114313 771585 646576 147 138 146 32 m3 3 809 664466652915 1n9o2 119418 1F2Y0 110s0 21238 112274 77500 646635 27 137 80 166 150 144 78 664d66666604 1335 n92g 113023 11377 112200 12047 76699 646673 108 no ns 13 21 no 98 Group VI: 100 mgkgiday 664466550015 646510 664466553546 646578 664466662048 646629 646633 115652 118315 n14e8 u18s1 1m30 115417 0926 132 130 33 126 128 143 I 113377 112398 113372 113353 112997 113a4 782%3 139 130 128 10 " 19 98 17509 12a7 710s5 681 61132 2a3 37738 i2 Im 53 9 133 131 654 ns nm 11 137 8 mn 703 - os Company Sanitzed. Doss not contain TSCA CBI F-24768: Subchvoric Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproducive Evaluations DuPont5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS. N"Aunmibmealr 1 Group VIII: 0 mg/kg/day WEEK 13 Stccessive 10-Minute Intervals 2 3 a 5 6 Toa 646506 664466550480 646542 664466554485 664466569198 646637 646650 nm 23 155 129 147 94 765 11350 115502 1n3a3 1270 112o8 113549 570508 138 1s 18 ns 74 102 82 n14s3 112580 n12s9 1080 12595 1088 669388 112375 12233 1127 11275 110398 13226 764 113 129 128 139 132 145 786 147 134 tas 153 185 130 854 51 Company Sanitized. Does not contain TSCA CBI 9H0L2.4D7a6y8:GavSaugbcehSrtoundiyc iTnoxRiactistywith One Generation Reproductive Evaluations DuPont5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS NAunmimbaelr 1 Group II: 0mgkg/day RECOVERY `Successive 10-Minute Intervals 2 3 4 5 6 Tow sdes11 646549 664466555615 646580 646581 664466651836 646621 646652 101 24 6 66 114357 11446s 130 151 n13o8 12276 116 139 112268 n18s0 120 120 as 8 31 6 61 0 341 113487 115465 112583 12085 876958 133 2 102 101 23 136 28 149 si 73 im us 8 3 721 175 no 144 120 139 6 135 130 858 10 13 1s 22 n 7s Group VIII: 500 mg/kg/day = 664166550068 12297 112367 18363 126 104 116 155 21 135 702 803 6s4d66554402 21329 136 ig 100 102 nm 108 95 139 147 2 734 70 646545 646548 152 137 1a 146 136 123 16 81 B31 122 147 7m 13 m 664466569198 1n2s0 114542 1n4s1 113546 12672 18962 788116 646637 646650 127 135 143 183 147 m 61 137 101 153 104 Ed 683 810 ER I -- Company Sanitized. Does not contain TSCA Cal H-24768: Subchronic 90-Day Gavage Study TinoxRiactistywithOne Generation Reproductive Evaluations DuPont5990 APPENDIX K INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA -ee `Company Sanitized. Does not contain TSCA CBI 5102D47a6y8.GavSaubgcehSrotniyc TinoRastsiith OneGeveraion Reproductive Evalsions Duron 5990 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES oEroC adequathe ore ""V5 iRT T nSoosaxaltmaepksleenetoT ctelcnseoistvedpBeorfforrornteatdsotninegs ne 8B 5 o SERrIAaL. ICE SnttvtioiotRBuHTemaf nItol?obgh lyomnvdaastsaeilsio:none HY ww mCmeaImnSeS C orpiusE m cullar eve EoluHmee sRis concentration a a330m BApiRae EcEatTAerHCTAounnRchToconmTeI h former ~- BNNBeonyrD SSmTmheeSsie fA mt mms, precursor EeeBCCoC smamhmatemls mEEeenaaainenecne NBBBTTDC SRSEhiIeasS R m I mml iscore BSpMeiEC mSc ReltiRar ms eISn RmmRaebBeeentlee, BEEC Diuei entnenmbeeesns aNCC rSReieEne mmtoRnn moenee _-- Company Santzed. Donotscontsain TSCA CBll ars. oa nty Toryitr Geren Regn ins mmo - INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA simitn,etceouisnoEXtPLiANAeTOnRY NOTES (CONTINUED) EE5FREC Eh pEiSe. 5CE| E Ele a, sait5hBs:imEeeEBSEieTiEagea1 raeee rns ve m en ent LELEEEET amos sn ee ie semi conti ~ egm iBicCpmn ahwee: of EEE --_-- Compony Stn. to= es econo 20o6asGoSmatoSitycTmotssihOne Grr RestsEs Durr ~ INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (CONTINUED) "etLaLe tn a ie2cies aes EBE CREEE e E Af Hiei &ZaEne SBaEnE sere f EE esEHhEe.ehlstrteohnweielaetls oorrchceehaictnsreeemiiaiecion ~ iotEL ra raL st w, i a wd-- of5f E EEmE iret of hemos sn snmtrcion EENEE. tosBCe rinEcoR nteEsmtaion aves E fe Eh minem HEE --_-- CompanySst. DoororsinTSCACal H9L02-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont 5990 - INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (CONTINUED) xRecdopBtliooond oCfallPlNaetreplheotlocgluympVsa)l,uesa,sdWhSipteceiaBlloOobdseCrevllati/onPsl:atelet Morphology Values (with the TP ace 5 i moderate Platelet clus will be graded as 1 1 present in any amount. eine Microscopic valves: bor highdpeomer field poTr ehighdpR orwer fE ield EpeT r lowdpeoT er field e por loudoveeTr Ifield modeE rateE- )1150 moderaantye | S2s6o.u5/0t1i/elideid HHEEE soderaantye 101-50 tWhheanxiTnedniivoindsu.al31a1nisoaflwndiactha aarree onoutplacionpeordteidn, chiet ssatyudbyerdeuceordtso ono of the following reasons of ShthoeVrasSawmapslTeaimwniaelsutcciolicnoittedcnetdnots(acrbupoelme)o.btfaoirnetde.st(iRnWg) (NS) 5tt"hheasaasnraipmrtpaellewawdsai.sedanvoaptriiloasrbulletcaobflsoefampTfloeerstcitnoeglsltei(ncNgtSAi)on ohoenrnifoasTnmoradianandnyivihcdaalulfaclultaohtebisoesnresvcaoptreidroefndorwVmaaelsuder:iectohrFdoertdhaetaxsamBpLblLeeii,FnugbiiflnesBsdialtitarh:uabnina wcaesrtacionporvaeleude,hsca0l.c1ula0i.o0n8swweerre WYhoeRrna apnMeeceiionirdmivevaidduoTanolr tohabonsyerrSevacaloterivdoienadtivwoaenlsuser.peecrofFroodrremdeSadasmwpiblceehi.ngtihfgatreSapEtepceeircfiiitcihcaGnrGaaEvMciLotLryYtauiednsatavfaalpvoer,iedcalaecul2a1t.i08o3n,s T600Company Sanitized. Does not contain TSCA CBI -g 3 2 enn Bf eee Hunee E2i | EgLrEeEdEEdEaEnEEgIaInE sEaRnEiREaEEgEnHe EB | siiEdsa AREER i | iAaiided daa fer) pmmunn nuns ~ i : 5: FF| GEER dssESEdEE FI "| dEnGEG umn g i B| EIEEEEEE GRMREEERS 3i " 33 4 7 fagenaeane gemannease z3E| 5"le. 2B E29 2 EF gxssssssss ssssssssss 3] 5 28 gd --_EH iF | 5 28EEESEEES SRIIIiIiEs 3 Company Saniized.Doesnco ontTSaCAiCnB -~ 23 3g| ddmnugadasmdainzad RSEdadndmdnndadassn F | Iiindedad ARAEEEEN #| IiiEAnna AAEAEASE fpr) soessmanna ceweanunos g | sgdggdinds sdeddnddcs --_-- 5 $ g : BO GiEAAENE dEaMSaR ' 3 Fey ammo meen 3 3 | WO $ "2 a7 43| #? se3a38n3zm9n98n7 ,| iol 5 1 : 22 | 8 sssumEEEss 5 EE si osrensssans | TE nmugmsgEesMNeMs s55555558%8 azsmsoanes --_-- 3g 3 3 GompanySantzed. Does ne contTSaCAiCn81 ~i al | EEEEEEEERE BELEEEESEE i] EEEEEEEESE BEEEGEEESS | 3% sanueannas 5339344943 gE 3333353358 355%ddais : iSl ifi am3vnammen sAvAgmsuny 3 2 RI2 2o9l 2 2a2g38 5 --~35 : 3 % ge3i1|1 ; segeesersssr Oi pesssesees BY3 | JAI33E3300 5 JSUSASSREIAE 5| = g 2if11| && s8p3r5rReSsRsEsEsEsE & e2z3sz3se9ssSe i o SSEsisziae Gelssiig i i Company Sanitized. Donotecontsain TSCA CBI ~ <& H EEEEEEEERRE EEEEEEEERE 3 | EEEEEEEEEE EEEEEEERES 3 H Vn nan - i;Toi") IsmsRsesIssEss TseImsAssoAss 3 3 oF 2 EgE:B | sFsiarzEaAsEaNsEsEs Izusm cessm uay : g g 2 5 3 & 22s 2#85 -35 8 o1 GATGSAED SUGLIGLAGA i | iddnddndn | isaididnd oi i 3 & EEEEEEEEEE o EEEEEEEEEE ile i5 B58 gamaaRaEeR UosRmean oir ! orgnssrens 5 cesssaanse i33 ]| P 3cE B3g8E gsgs g3nsgganst 2: Company Saniized. DossnotcontainTSA OBI - 83 os mmm mann | TEER wana E| TRE Yam 3 ge J3pa002900 Aansaiana Ty P| RUNES TE : i Tr WUNER RanuR | 5 89) panna saEmNnm & #3] ; sawasasaan d camaazacas 2% 3 13 ~3 g F szzzssssssssssssss ss |: E i { sszrasssss eazsassane Fld i CongaSats, oes cana TSA -g #2 an5928R378 39ANKISRNR 2B3i FnRdEdReREnEgReAdS cRgErRsRsRgEdEsEaRnR | ENED REnEn #| Sindmaiads dAdaddddad :i dl PEE KEEPREFEPR EN = | CToFo) daumeamesmses acommeuncseee & EE gi | DunED mmm g 3 | B2a mmm aeanvannen mmm anqae enna iE| 3Due)? | :smumsnenss :& ssasnsssss =3 il E I 3 E :: 24 2 8 YEEEEEEEE 7 EEEBEEBEEY 34 33 sessngasce | ssszssaser ~33 3 com Sante, GaoTSGnAGO ~ 33 | EEEEEEEEEE i] EEEEEEEERE | asgnguIIaE EEEEEEEGSE EEEEEEEESE qATANEEIR ~ 1 lees go; BY] IEIEaAEET mmm $ ' S| Fogx| ssammamamns aEaanaaEs 2 2 i: Bi:| sassRE asEes E asnIE assad: S2| 2331]0d3 EesesEEEss 4. seessusEss 3 22 i 2%2 |1| = smgaamnoum gsn zmosamanca ias 3 --~ =388 % TIIIILIIIT 3IIIIIIIIII i i Company Sanitized. Does not contain TSCA CBI 2 # | EEEEEEEEEE EEEEEEEEEE gi | EEEEEEEEEE EEEEEEEEEE EI I ichEb hh :: 58g) sI assussssn n ssnssn sagas g BF 3%aEDEEIY 3NEINEEE ' 25 $ 8 of z52g 32 i3e% ~ 1g 2| 2 Z ile B4|38 i: 33|| Gseasnhgeesrsseasgss sg3rnenegreanssgsesg pEmEREEEEE Sa3naanaEaEnEzands i| GESEEEEESE i 8oagmEsEmemnEvaIaEn ; g3e8fEsapgsioaennasg gfosgsfEsnnoisssny:s Company Saitzsd, Goss ot conanTSOA GBH 3: a TREE SEE i] FREE Dann i ge AE iiaes asnnanannn Tog te opummn mmm 2 iy kaiwkn iyJc ny 2 : | rms mmm i 4 msssssenss | nmmnon &% i 3H --~ 38 g - BEEEEEEEY v EEEEEEEEES |: uf ssssnesesr | sermssens 3 2 CoanSarin, ti son8 ~ 8 El EEEEEEEREE EEEEEEEEEE 53 EEEEEEEREE EEEEEEEERE "| IERIE MEEEmIEER Z gi) seszEaian 3ngERasEns {iY f Pu) vmmem sme : i5 i5 gi 2ESISEISAL 5RN2IERASY 2 % 5 BEg Re8 IRENE 3 i 31| EEEEEEEEEE | EEEEEEEERE 2 3| 2 2 23 33 3 211 2J srvaeamaun ? aummnenes 3) 33 - REAR C WERnIAE 2 {| : : 33 --~23 4 | 3333ITIIIT , EIRENE 2 ES [A ------ ; & jee awa nmr GEM %63 $s3s8a5k dAefnciesd FdEarseds aF der je | sai gana gape BiH mmoFt EmaEn BIE 3IMI fg) ame gamma nan mses | i 4 Sas Gdddi dass grate ' Fe ose momma 3 : # | GEAFE3EE IEE GEE $2 4zdpms nme fam 2 sem 5 He Por 22 HALL ssuss 3 sEEE 83853 3 M 8 2 3 z3 Lqi d spss mses f oams f amass 2 i] 33E , sREsy . sEd sEsss --~33 2 3 2 i Company Sanita.Does no conTSaOAGnBI - : 53| Emm seese sees sess 3 EEEE EEEEE EEE ESEEE | EEEE EEEEE EEE ESEEE 4 EEEE EEEEE EERE ESEEE " EEEE EEEEE EERE ESEEE S3gr)| gIaene 3TmgImy sBmWn 3EsmEen g EH he BI unm nm 1 i: a3l i. H IgSEeEnE ASREneEn oLERIS HaERmE ;| 43 saa3g PmOTmTTm] snamne emanege & LE 3 g 2 pee Coa 5 amm i ame J REEL EEE, 5:3 l 21 Fesapks ropes fioams 1 esssc 5 Bi| oc 3agE TRIER 8 amv nases 5 --~ 23g8 s8 |. E3% , EEE: EEEp , EEE: i 2 2 Company Santzed. DossnoconTtSCiACn1 ~ 5 | EEE EEEEE EEEE ESHER %| EEE HEEEE EEE ESEEE 52 | EEEE HEEEE EEE ESEEE 33 | EEEE EEEEE BEER ESELE i* fay) smer meee EEE GgEEE FE - | EERE EEBEE GESE GSEEE Md | | sEEE sEEEE EERE EgEEE 2 | BEEE EEEEE BEER ESEEE NE 3 3 7 &$ $i]52p EEEE 3 EEEEE 3. EEEE g|, sESKER 2f22z3 2 | Peeps :92 peers g pepe E: pgees sf i : ic 82 oiiFuses ioausen :| oases :| snes 289 iBqR;& 9B3EFB%E , gPE3R3S3E% , g3a3g3s , g3iEgGsE: -385 * 2 3 2 CompanySantized.Dossnot contTSaGAiGBn -~ i Bf moaamim gumEm Yl SaiiidNEa dENEnEEE EBE| AfirdAiRAedEnB A IAAEEEEE Ee IgEINEE roman Ty P| #iinscanad Aesrssdnes 33:4 g Fl iEddsiNedY desis 3 3 g | Bai GRRE : : 1) anszgsasserasagwsss: 2: le i 8 | me 3] " I T sssxssssns a _i4 = 8) Hl pT ETT Company Sanized, Doss no continTSCACBI 3 | HOTEIN ma 8) EAdndAniAd AMESIERER : # SidEddRdE ATEREAEIER - ] : "| adidcaias geri-draan t 5! "Il 2 B 3 %| fodassiad GEIR 3353593330 SaadRian gi | | SRTIZYBIRR F LUNREEIIES TIE i 2 ssssssssss Sr E588EEEEEE ~&3 =8 tl goes gem Company Sanitzas. Dowson TSA OBI : 2 gs | EEEEEEEEEE EEEEEEEEEE 2 EEEEEEEEEE EEEEEEEEES 53) 33330ERREY IENIEIEEm ;% fay) semssmsnas zasansass i i {| I3IRNEE EEnEEAEE 3 E I33AARNIID IINMEEME ii 3 8 IaaEEaasr AMERY & 83 i sEREEEEEEE BEEEEERESS 153) "4|1; Raroaznmmanaze | eReInEavmIsArRaAnMs 3 gl 5h2e3 9) =| ] iHIERi QTL I0T2IRE ISSCIETE8I8IEET Ri, ANALASSSLS 33TIIIIIIZ LE ------ ~ 2 3 | EEEEEEEEEE 52 | EEEEEEEEEE BEGEEEESEE BEEEEESERS 8 TNE TEE Fa 2 23 3RIINNARS 233MEIINAD 3 "| saEmnEEEET EEmeEEEER 3 :3 agl F%gg:| nssmammman snymes2s2e9s5y8 H # p moo m g8 |51| , deRdodBdIisdIdNeasy | & 3 33 i: S2 E3i.2 EEEEEEEEEE 3 25 :% giE:2 58: it i 8 goezgencen i 59) 38 ( $S555898SF 7 zg A3iIdAdRESdIiGdNnS EEEEEEEEES mann gEecasans Gsgssises `Company Sanitized. Doesnot contain TSCA CBI i Hi "| fdsdssgsds 3esfdddddd 7 AVI adaadaas #| Arianna AadiEatams 3i Ssidzasnansassads cneadnisdsasdsans f fe nmunn mene j : ; 1 | BONNE BORE g | 33 %|S| Is3namaa%zaandassdss dsd3natEdnsaaaaady gr) emmn | meses iHo iy _ Ez ig TY 8 T sEEEsEEEs | EESEEEEESS os 8 srcerss | i 33333333 i BEIITIIIIT Company Sanitized.Doesnotcontain TSCA Cal 3 yoann Tune 2} e | aA EGER | RERER RREE Pe ER BREESE i| 1De) mamas samen i HFII a LOW BEE g ] E 83 i: z: & 4Ei] . i : 23 | EE 8. 3 : nEmnGamnEvaTnn ane S8BITITLT BEZEEEEEEE . aGrNomIaAanRe i: nanan F SRSANIRFST g ::. BEEEEZEEEE _ Ez =| i i F333333333 i F33EIIIILI CompanySaiz. Doerocots TSCAGBI Z| | 2 EEESEEEEEE EEEEEEERES gl EEESEEEEEE EEEEEEEREE 42 | 2218339438 4234493333 293 3533590088 S35ETEINSE - g2 o;IaeF| 35333383558A5) II9I5Ekm5RRAEEEENES 2 i 3% 34 FF| seqgnzuess gasEAaasaq Elg i $3 2| $ 5 3 i8 ~ag4 8 BE3 SEensEaTnR ERn RseEampaecnesasme i= * z & &3% 3 5i Ei EEESEEEEEE | EEEEEEEEES BY, 35Isnagass | namesmsaan 3; i44 | io sga8g5apngnEssaEgses `. Sgiafsgeissainisszee i | i IIIIITITIT ji IIITITIILIT Company Santaed. Dossno contin TSOACEN ~ :i "| EEEEEEEEEE EEEEEEEERE EEEEEEEERE EEREEERERE 4 jun Younn | 53] HEmmEE mamEm z 3, Smunn, 2mnn $ Sle 3 2 3 . EEEEEEEEEE ? EEEEEEGESE 23 IF g i "| TRER3TIIN g WUEYIAT 2a 12 ; 22350203882 | 208538IgEs 39) 3 4 SSEELEIEST 8 fsEsioiiss 3 CompanySantas. Boos notconSOaA Gnl - ! BF Ema smanmmIm & | GRANAdNAE ASRANENAR : i | ERAAAAAAR ERAEIAEER : | iiITasaa pads g Po) summn means - qc | se 3 BY| 3RIEANEAAE gp A3REANEA i i i ig 41) , TzuhsesRaagzEsMaNs 2 eosmsenmemssEsNamn 24 12 23 ~ E E 3 3 | 0 sssszsmssy ; zsssszszs: i i i ; GOR228RCEE RRIISISESE Company Saiized. Does not contain TSCA GBI ~ H EEEEEEEEEE EEEEEEEELE gi EEEEEEEEES EEEEEEEELE 5 i 2 ge 5338388288 3328858323 3nagnszasy 3R83n3EEBL - I 3 3 iF al8| I OS g3| AnIa9sRrNeAnEoAmYa o3m9g3uRsIgRnEoInN i * 3 HY I i Ri be 3 iz z 223 2i,e 3i 2 3 z EEEEEEEEEE P BEEEEEEEEE Bi, aSaREREd p REE Hy i zg Gompany Saitzad. Donoteconstan TSGA GBI -] H 435 %3E33 EESSE REE 4 igs BBERE BERBER BEER 52 | Bigs dfn Bhagh geeky 5 | sign ooiEnn eEgE gasel 8 | S123 onaEnn eEgE games fpe)oezmnoogme senE gp ~ CEs En en ose 33 i? dl 333 EID OEENGE SiR H dPeyoE osm osm seme gos $| 5ile BIER | DERRY p3 RENEE E ommsR 5: Hy @ : 3 2 9 |o $g58 es seBEmS e BsEERsRyY gp sugPReESr 3 i : 54 --Zs8 lps gE EE Company Sarita BonsAL ATSONSRY -g | EEE BEEEE GESEE EEEEE 2 | EEE EEEEE EESEE BEEEE 52 | EEEE BEERS GESEE EEE ] | EEEE EEEEE GESEE EEEEE i | EEE EEEEE GESEE EEEEE SFgri) edsds s3u3e%s EES$FIE 3g3FaRSmed . i 43] ess aes mesze samen * EiI ig | Jsl Fgr)i e3n3g8 m3i3esS: sesSF3e adidesy : &5 38%2 E< 05 ~ p3L5 5 gi) eas GER sense g osmess {| 25 g 3z z; Bgiil)ye. gaRn3g2s G| IgFnE@s | i EEQPAIFE P : BShPERE]R HE :: 1] 7 sRZ | 8%EAE | EERIE , [BLES ly rp 211 % sams f ngpes 8 megwe & pmase $285) i|; $g3g8E%g i PBEEEREEYD i; F8I3SE%R i. EgoSESEEd Company Saniized. Does notcontainTSCA CBI ~ 5 | EEEE BEEEE EESEE BEEEE | EEE EEEEE EESEE GEER 4 EEE EEEEE EESEE BEEEE | EEEE KEEEE KESEE LEEK 3 ~ ia i 8 ge) EERE EEEEE EE:SEE BEEEE of Ey esss sessE mESEE EEEES : S| Fog3| sess smess ssseE gEsss g z ofl 2 1 5 23 S| 23% S2E 22 E34H3 ~ 58 g3| EEEE EEEEE EESEE [ EEEEE gi| iFumes i| ommee 8| segeiner 8 Ze z FE i 3z 5: g BslIC gl; EEEE |z BEEEE | EGER; s. c E i3 3 3 343H515 sF8a8Es8Fs% ; aI8s5Es3Ee3Ez8 . as3sEeEsE zEEEs . ii i i sess sEERE aBmgagsEsd IEEE `Company Sanitized. DoesnotcontainTSCA CBI d Garon nano ' Dron tna 3 mip pee i] meeps pense i2t] Dn rnin -~ i 5 81 [H:I .-i Dino mn ig :i 4 "| Piptaanin prinninin & | 2% 2 "282} --~ dg Bolg le Bp pe i ; : i | .&i 2B2R5E0BSEYRSEEEIETD |8 EDAETRIiIRSEInLiLES 2 2 GompanySaitzad.Doss not conTtSCiACnot ~ | Bririiries trrrinn Ii] nm pannnan aan ananan fiee) Cobre Ty 1 nnn - 1 | "4 tranny rian i ak sven osninerns 3 : g 33 351 sesagzesss ssssszases ~33 x Corman ers ecsomnG8 ~ f3 2 i gi 3io:: g3 dqi | 2 i 2i2g ~3f z : . 2 z i : :: 4i253|| ;i 2SH 35Gzheia35E zgseEssy 2GSIazgHimiaisEizsaEilse Company Sanlzad. Does ot contain TSCA Gol ~ 3 3] i i --- i gi EI i 3:3 2 3 5 3| 5 zg ag 8i> :i: : g i 3 is i: i] SEEEEBEREE , FEREIIEEE i 2 `Company Sanitized. Does notcontainTSCA CBI - | rnin imritrirn fl Bertier rnin flz 3i | Seman apmimanias aan jee jeans i i Brrrinion nininins 0 . gli) - i i 5 3: 2I Brrrrrrer tren g 5 d Hor 22 z 22 Bogfg iz . 3 ~~ i i 2eI2858838 i BEEEEERSE 3 3 Company Sanitized. DossnotcontTSaOAiGBnI bo2 "| Giri toni fl Grrr ton iit] Giriiniin miinieiiee --i I g ig | emo HI 2 | Garrone no i `| ee i 8 3 & 2 Frrrrriminy oper E 2 i -~ 23 BT > : 11 smrzmsmmmsnnenense 2 2 CompanySanitzsd, Doss not contTSaCAiCnBI ~g z2 5 8 ~ |i gI 3: i: i i : 5 2 iE3 - r.i 38 gf sscessenns |envsnssnne ) i | . G33ESEEER | sEBpEsNEd ---a5 2 2 =8 FS -g z 3 i lr ! H:I | 5 fl : &9) | > --2 H 57E| ogd 2 e EE E FE xEPEino ~38 i i Compan. sonstosnnG0 ~8 3 Cie en "| Berrrinnen tirrnenin J Prirriien rnin 3 | hina aren i i i Cinema Pirin Asem tetera --~ g a $ g fd 3 Te g5 odi : | See : gi 22 55 38 3 ~~ Z| | z Fn LI 2 E Foon " ii | ssssssssss | nusrsssses THERESE Company Saritized. Does notcontainTSCA C81 ~ 2 - i $ EI 3 oz 43 38 i3: Z| 3 2 2 i3 oF 8 3 23 3 2838 ~2g :E 8 35| 8E S8535338s3 5I3nIniess i25 ]| ; HGEaEgszinziazz og3ngugisininiyE : : CompanySaitzsd.Doss notconTSCaAGnBI yo | in| iigE !1 i i "I BHrey Bg REE o BREE n BOM'S Hop mmo 8 2 Pi pire pind EERE} Hom om om Geo geo goog |p ioigeeg 22 i Pose % gg2es 3 2288 gee 13 : 8 : : =8 ~3 3z :i 2 - g i :2 iH5I i 3 8 dgf so;isBpi2 oEo % x: fg CofEp Ei 2 g LE It5 HHPR Tog DEoEoEog it 9% eses asses fares fossa ~g8 2 2 2 3 SORTA SomTERS 3 Z 2 :': : EE H Grin anni iiet | ETT Gin -3 $ 8 i rim mmm ' 3 : i g3d rie iain 8 HL, So 83 g (3Fon iann 8 LI 2 2 i32 P I;S sia trrEad pirririnesisns _ 2 =8 iz | i IIITIIIILT i BITIILIIIIT SarpySuttons. Bousomtcona TINR! 3 d ' | 2 Gin Dini pm nn iin ann iiieE Ginn inno -i & 8 1: 4: !1 Genin tnanan jF i gos ie Bonn id |p 320 r 5 n |5ose ~if i f GompanySanizsd.Does ot conTtSaCAiCBnI ~8 2 3 i : . gi i3 83 i g3 22 23 5 2153 3 3] EH ~ 52 8 : ' | 1. 33 o 5 FH | -- ! 35ERgussIe Hi] TTR Company Santzed Gossnt contain TSCA CBI ~f i i i ~i & :HI a4HiI :3i 2 for Fogo: 3 2 3 LE] 2% i i 383 i 3i SHEE i Hanne -33 : CompanySts, SoestTHEACB i fi:| ape eee i iftt] Dini en 2 I | prppimmm eee. ? 3 3 4 i 2S| iEed 4 3 ~5 28 i prin % {| Z Pirin 2t ed priPgiriigeodgrininon 2 gs sy & sagamnoage sucesamess i | i 332TIIITIT i TIITIITIIIT Comes aie osc ERGE ~ ]8IEa | Doiriiiiin trina aininiiii irra fl eine mmo {mee 2 i it wiiieiiin meeps So , - g 2 33 i3 7 1x 2 5 Boer 2 : - i coySeiad, essen ~ 5z 3 ~ i & g1 EI 13 3 : 2: :: 53 | i2 E2 gs E : tg if : Jd j TERpER RRE 28 company, oprah ~5 i2 i 2 -i EoIJ =:2 a3 4i 3 bose i HE IE 8 it = 2a Bi OE LE |: 3 i : ~if i . : igor 8 Fg : i CompanySatz. Doo ot conTtSaCAiGnt fl Ginn anion 3ol pape eens i i2E seshrabaes prinnina g fd ! ' 3i: o:3N Ginn ain i gl c2s2 3 - gg3a8 |. i iF i 7 g BEOLT l:rriiiiiinfnio E ririiiiin % :i 33IIIIIIIT i IIITIITIIT Company Sanizad. Donoteconsan TSCA CBI Z| i i --- i gl I Iio]: gl 3 ; =3 i 3 i S2| sz . 2 P aE " | i i 3 | i 5 5 g |. g 3% g 23 43] C 53osEEEsel o gERdEsaies 9 53 | 3FsgssEssy FisEszaiiz =8 Company Sanizad. Dossnot conTSaCAGnBI i | 3| iE 14 18 Gro i Hot IEEE is | HERE Tog 3 28 ie | roan oa Ha . g ii | fod BOE OE ' i gi i |e 2 gif, 22 |: g: FVeiEEdse g22 s2z 2. 2 i 82 8% 2 ~i525& 2 i35 33IIT f 33333 i 3233 i 33TIITT Company Saitand. Borotwcomsin TSA GBH ~ 22Z| i 3 i1 : 333 :33 gi 4f z z :2 Po i: g Lo : i g z | l :%3 ss? 25: 22 i | = = oo x [LIFE FR FR PR ~ 534 i i ! i CompanySatna. BostonianSEACH! ~ : fl & if i] i piraniaae "irditivig 1 3 Prrrronoon rrnnnirrn ig HF fn ~i ; ~ 5 H if i {| irri piri EE ; ] i REEREEEE rani 4 i it ~2 i | HEU an FH szgsssesse sssgsansge i ~3 z 55 B55 | gg 88F i" | pranbnnn ii El mimpgmerey 8 REERREE RE] mprrrienn: ii :i li 3 oid EEREEREEN] Brrtriiin piri anni i * $8 lp 2 z PoiHfd F|::BoigTiagHiigHig L'ogCgeHenEiaWg 9 ~38 i] . SgsEsgEseE | samgEEEd i i Gompany Sanitized. Doss notcontainTSCA CBI ~ 5 5% i i | i d Gin ani 3 iFoo rrrriiiin niin 2 Prgmrrinnr prarrrrges 3i | 3 trirriinng Pritiiieg :FiLe Gren : anna { PRET 3 : : of 1H na _ 24 8 2 i IIIIITIIIZ i 3TITITIIII GompinySanitzed, Goes et conanTSOACE ~3 8 ugg | 8888 8% iEid x | Wppepeemiy eprrrereny i1 5 is IEREEREE RE trrErinand g in Grn nn d 3 3 3 - a : py HI E TUL HT --~38 i 3 Company ana. sosetnTAGE ~ 2 iHe REE shan phd prin : i tn ii Brig it = i je tet sifr rnnn rn # g i bi sas a pid pa, 3d I] CREE iyi shad : asus 3g E & s FL...ER 3...G8 e 3 z : 3 | foes opus og ospre CY ogpmin ~3g 2 2 2 2 Company Sart.Dossntcontain TSCAG1 ~ i 5 Ji 5K iB iFoo rn tn ' Berrian ieriiniee od Fr rene mmo B i H i trian Birrtssass i : i trrrrrrirr rrr : : ` is 32 _ ig Bo. giisdsaais ii 8 228843588 N 2 23%%8 2 i] i 3TITITIIIZ i 3T33TI33I3 CompanySais. DrootcaeteTSCAGal ~ 2H | Bf#E o8 d5& &of@ 8EE6ii . 888 7 H% HATE Aaaiaae ElFoo nnn nn 2 mepieiie impippeedn To iide een an 2 i trian thivenae Ph 3Bodie gn i Bp Bri Riis ~3:3 i i CompanySean,Boersatan TSOA GBH ~t | 45 81 ii i]2 i Primers pnnienien EN : i Doriiiiin iii [3IE i Brrrrerenr rnarrerec 4& Boy 3 R Eine Cm |= didi i T: aran EREEERE RE : 1 i 8 CompinySaniized, Does not containTSCA CBI ~ i (otro LL it Pitrimiie pmeesigng i BH] 0 | Hid A RH i] SERENE {SERS - g 3 55 55 5 5% Hi 13 1 iE f #1 88 # el pRriinion IRERRERERT! ie | mnie Siping o i Prrrrirod oo ninitont: 33 i 7 i Brn gg tn 3 3 dg F af i ng rns gb: TE mT 23 ~353 48 1 c GEaEREicel | gRIIIASEE [&] &g corySats, BostonTOGA GH ~ f| 1 iret IRERE IERRN print 3 ig tin ogpn ti gi 2i | x8 8 4i . d 3 veer orrrtr arin tan = E i E3 g Zs tree tii iri Pies EN q 3 EE IT dr) 8 2> 3i 3z i: g& sf 2 San snr an z 23 g F 3 i se Te Es5 Fles VE-%2E :3R Fos 2 sCUrBuEptp BaRgeYR $ SE! 3 583% J S3EE% 53%%E 4 siEst =5 `CompanySanitized. Doesnot contain TSCA CBI ~ z : ~ 3 5 P : TIE Ramm " g | PEER Ws 2 i | Pam mann i 3 | pi : yssaann el Hie ahannnnn ~i2 i i ~ - J : | inasddndd EAEREAEE : i = | iiRE3iRdid ZReasaans i | Hine jEEEEpmn : 3 : i | BEERREEEE , BsERRREE 3 i |: ggssasssae sasnaaeng ~8 ; I| Pfup ams mes f 1 Tn GERdeRdi SHEE | mn i | aE HoH r) a 2 n : sn ~~ f : ; - 2 | sreilioaer Ameadanad i 8 fo monn Em 2 : `| TE TT i 5 : i || man : mmm Ho | gn * panama ~ 38 & & ~ : - g i # GAfingsddd Iansiadsas : 3 i 5 G3R3RENIEE AAnAdadiat i i | faEaananes o sRERENENY i 3 i 8 i : i Tho gasagaesgy 4 i i EEE EE 24 8 ~ 33 oi g 6R27E EzRE REE g ; BPaBn LERELi |i ~i - 2 a sREidadat dada : : Ha HENNE Rana ' I, SEMEN BEBIBIEME [I || mn zl gg Ra 2 BaRsagEELE 5 fansnnEny ~3 g4| S3uEERRIGT YERGRGREER ge|| 333A3R3R3A3N3E5R8R 3n3mA3m3nE3m5An5g | BIARANINRR SEIRMADIAT A| mE EEE : d 3983968 GOARESESE i BE| SEEAEEE ARdNERE ~ {| 4 i ; # FRRARRRSAS ARARARAsna ' 33 3 i | guRRESIgER LEeeeenRER Bo: 1 | gepiseinar onmmmnnems i | maa ! snnan 35 i | - JEREEERNE EREMREREMM _ i H SEESINEEE , maEEEREEME "3 | szszazasss szagessy i smune gmmnaane gy( reewwmms sstmnsaans ; Fr | 38I%A2SN8 AEIRSERNEA ) | Em ween i yr R sn i 3 | Henan : seamen iH 1 | eee | Tee ZH 25 3 vpmunpens b peopnannuE ~ 52 i 5585535588 SRafRnaAR i | SIUISINGS GENIE 3] S2I333ss%s Sesussenss } | gR33zINzIc $ET :fue)| BsRiAnRmAeAaRnAsRn dsm sSaAnveindaannnnaeed J: 83] IEIIWIIW wWRWIIW : {| 1%13 i 3} Bd : B3| [EE mma 333330 EI; | LT 2 gd| 5 saggswsasy aggssesysy i ; 2: z 5235 E83'g|loF: ossgeszenss iL agsE eargaes --~zg Company Sanitized. Doesnotcontain TSCA CB -~ 8: % | Saisdsases sanezsasss i Iam ERNE 2 NnwRnL sIenm ] | 233IIJAITT I]IINIS cE - Im momo num 1 383 Sa anasnaa " 3EI 5 day) mane omnes io| a5a fIaIaeEaSrvNonNn cNnomE nnnR een g 2 i g3 3 sasgegeses geggegsenr 3 : 2 ge | IanAnEARAs snammsasan 2 s $ 2g 33 seazgsescs ssssssasss --~d3 2 i CompanySantized. Doesnot contTSaCAiCanl ~8 zg 2 i , 1 iz & LI 2 3 2FI i 5 $ 3i #: 223 oFg % 54 5s i a 35 | & BRIIE5EE3T & S3ggggsssg i: i i FEzgzziEed E3FEIRE ER CompanySanitized. Dossnot conTtSaCAiCBnI ~ 53 i i - 2i &. g= ' |: LI $i 2 2 . Z3 es 2 23 3 5 ~ 39 :3 :i a2 2 B i g )8 > E 1if2!| 5 s3pgaEpzuEsEoisieisE &I szeipzennaecseeast 1] PEEEEEEREE , FEEERRREEE i i `Company Sanitzed. Does not contain TSCA CBI - jf g 3 i| | RXLINBYIRL aIReaE azszazasss $R3IIR2BEER neEmaRm asaznasans i naa annEnm $a) epmseseszas cemegeuzer is: araIfcaTe SNEias EN5 3 3| ARESIARERA RARNRARSRA i EH i | %sssazRIRe FIopINENsE i i i | fEsREanesy Empnanned : i | 3 mney : Eaagaagse 1 : : tH i : jEResEngy : [Eh ~ 17] fgEAtTESYE SRrveTAves 5 Mn wnury | SNSARARARY ARNSAREER 5 3333nA nAmRAnAAms bi reressEgge 3ERESEREES I ; ] i sill : { 13 3| ! oseeRsssrar eagnegsies ) fegginangy . gEEpnaaen ! 3 |a a 2| ? mm i 2 ~d3 i iFIPEETITET] i $5535annge 1] 3 FREY 3 gEgEzass i 3 - i i faasggziny gsasmRnily il NEE Emm | mmm mmm : | [WR EER ! A 333323330 ddaEE ] B| SSAA ORBEA * i J GI IIIS 2 3 sara . saa | i i ss33zguans :ssazsgizeg foEd pu) Femmmessess famevepn - | go il Sidngnasas dgaseanise i EERE ET maMIRam HE ~ i | MIAN EERE i i ; | TINIE RRIIIINID ? | | HI . smnaaain EERE i i sERAvIARaT : sasangRsan ~i i ~ ff 8 - :i &. gf i 5 3333333333 kaa: gt Thies paansnen 3 3 |{ smn T panne - | gd i . i2 2 pf) ssnuooonn sIosssasar gt | GEG, TREE i | BEE pn - ju i] i| | seesRszens 3333333337 SR23NREIT8 agRREgaNEsR mam ASSASASESA 4 33333 IEEE J: i o#| i sonesu BRGREAATIC Senasanans SaRGRRUINS sondssssse | i 3| Eo: ] i| aasgegzen gppeesgege BiipnRene | pEEsEnE : i ; fasgsagss : gagesnagay bE i Hs | HEH 2 _ i 9] C gegszazac: soagsis: i i 3IIITIIIIL i TITTIIIIIT 4 | pp jm : B| SRR 3330388333 a BEERS Demnn i . - ] in foieneOnJ hhJed % :IE: | bo 3333333538 3533509 5 : - 38 : i ~i 5: Pi 3 | 3333333338 3333333313 i: |} sea apne H23 r] n 2 mi --~ 28 i 3 ~ i] ssge seney ssa geen H) mom om omm Pag) sr smmr sms sp Ii 52% Saige Toesd ; |: Jag| |r| wan seep am apes mn wn i: He HHH ggt or gd"pn tPpnr --32 2 ES 3 - i f BE BEE mE EEE 3 | ie ne wn oun ! H| mmo ommogEy Pe - ; 1H wm adm wm wm : ] i | mr om nm oomm i | me wm wn i i ; 232 : saage : 5383 : En 34 pe) Fass fares aes Dene ~f : ~- |b % 3Z| :3 | 3333 . 33333 . 3333 : SZZis ggl p:a i 3dom d So aman oo amd Coron o ~ 33 snzgEsEsg 8eRsREgneR BY] 3mammRmar mmEmmaEsEs . anses2anss ssENnesLnn | ummm mmm i 5 AEBRBARRSER axgsrRRRNn i "l a iianaas anagaisaz ] : | HABYRANAGE ARIBRTRLAT - g i | 2RIRYIRRES BHJSAITILY E] OE B HRMIEERNY BERRNREES IE Ho vmnene zl # i |- nn H : sauna --~ 23 " ; 8 | S3AnGEGEET REAREANEY | mmm mm | BERRRACASE AARNNARANS | mem umm i #| 53333[eRIR FRzINgnEeR ~ : i %| SEINEANEEE EEREAERE i : 58 | ASIREARLTE SRAESIRENR z i 8 | SBREIAFIAD SRES888RTS 3 of I ; 3 | BaEEEEEER . BEEBEEELR ; i | : HEH EH RE i ; | se 5 BEE _ 2 = i i 33TITIIILI i 3IITITIIIT ~ 33 i agasgsssas il IRRTANAAEE sassasdigss jomEmEmm il sifziddnas desdsiiecs | ITTFIT | IIIA 2 se 68% GEamiEss AEEENE i . of Ty) aman aman : 533) FI | 3 summa amqeanmane dumm asmenayane 23 ? EB i5g B 7 sanszassse 2| AssiaseRay E2 E3 E H5 8 CompanySaitzed. Dossnot contSaOAiCnal ~ 2 i | Sidsisngeg aesdscasis 3 $33338333E gEEERENEis i H| ENINIID SINNIIINII iz tE yg) samimeannn sansnnasae 6 3% EREREEEEER] EEEERREEREY HI | : g 0% Y| SManEIIEID asIAEIRNmR Bl 3a| smn amma 5 i" 3 4i 2 2: 223 2 2284 ~524 EE ea) mmm, mmm |: i: . 33323232833 F 3338583383 i 8 F29 |LTn3zse8mesn 8. RALessIIAe i 5ij51 |; sseaazazneesaseasn | sfaasgsnaasgagzEiasd i : 4i 333ITIIIEE f TIITIIITIZ Company Sais. Doss not contain TSCA Col ~ 3 i : i 8i . g1 - Zl 8 i g Hgo3o 3 H 299 ~ 4534 i 7 | :B B: sols & i10| 4 CBEEIRUESREEESSEEEER i i, sBREgRsEEOESEZEEsEdE Company Saiized. Doss not containTSCA Col ~ al { i . im s3 F3I = 2 i : 3FH 2i : i PE . 39 --_ 523423 Hl 4 Sopizcesas , SREGE3EGE3 2 ii SITIIITIIT 2i IIITIIIIII CompanySanitize.Dossnot contTSaCAicanl oo - z ge | 2 | goeseansEg mem AsaRasag:s mmm | mem mm Ses) saessanans seasasesas Pas daaandsane ddnesasasn i 1) nsassassgg Assyssauss * 2 & bE 5E823ERREE 883IFAESASE io: o h iibinaane } EERE gi Hol , Hn iEI a2 EH ~ 3g |! HERR :! Hip 35| 53333ER08E 3oEpsgas i EREEEEIEIY { IRENE |; i - i Hi] RRRRIENAT ARRMESEESE | mm am i RRAUGHILAR BRUNNEARLS | E---- {| 2RREIRITLT jERIRRRRAC . Li) mann mmm i 1 AWEITIIRRE GITINRALR R 1 | RR5ZITRRET SRAIZIRIRG 1 | Hoenn een 3 5 z : ; |; a : na LE ag ; sense i : i _i3 i i ~ Pov) uSouim ypey 3 semi suasein |i | mSEmEmD HDaEnaEn i H| MIIEE INE Z SE Dy) mami mam ~ in mE GE i 3 3) ommomno sem 3 ee) semen remus bho yey famesmmme | samen J TT 2 2| seopsenume | ssaswanene 2 |i 3 2% 4%| & cesavconue sucengeasn ~ if f i Coan Santas. soestsirs -f | WEE | EE we | me mmm Jog mwmmm swan N cman mmm - ! 1 mamma smn : a) summa mmm tL raadagante ebchich diene] d ; messssss masses i ge : srssasaats : sRaRAsAzER ~ 84 i i ~ ~f 5 |i 2 & g 8S fr|) 3333334330 2 3933LIIII Ii | | HanmaEmE |i MEEsEN0EE 3 B r 5 i | . bnnmmmEEn | nemmmmmnn iE i] i BEEzzizgss i ERAEEEEREHS iz ~ i i _i 5 g : IF ; 5 ; ge 3IEINBLn , JEAN go | ann BERaRRAE 34 ; | sn BeiRnREE 42 i i ~ 83 u|e csg33s9e39s8a8 sSsRm5sEmERsNsEsEnY B| iianizacsr 8 | assrmanir gamEmaIan: amaaniasas | mum mmm i 5 IRAidaadds SEEEEE i i | pragregesd cURvYARNAR : g FI 5 g gs it _ is i LH 3SREE35858 {3R3nRTSRR | geaggeaats : giagasness i | : FH EH ER EE i | . BEBEEREREy & Basstssens i | i IIITIIIIIT i TIIIIIIIIT ~ 83 | O jagIsREEaEE 4EREEEEEIM 2 F fisgdingas gessssgass i | fii vie hid = dedEaiasii GRRIEEENE i | WIEN III ! a iIisdEE sEIaE ~i f TH EmInI ImsImam : 2 3 a3 PCLT i : s| 3 s3| F |2 2iz H| Z: qacanerace IIIT azsgssanss ERLEccoLmsEiEne modeamaeny 5 III] ssegssgens E i esezmaremgaemaeEnasr ~33 i i Gompany Saiizsd. Doesnotconan TSCA GBI 2 ~- | ; g 3 ; 3EI. fg it if3 H| 23333333337 5 3333333333 i la i ; g | ; Henan genni 3 B 3 gs |; dese ; BREERIENS _i i] i 3EEEaTEEEE i $EE5EEEREE ~ 733 338% ARREY SESE AEA | mm ommoam om 5 =RRd gEaES AamRR 9AnsR | moo Im mm LH $32 SNARE ARANR RRAIR i 3533 IRR Ggsss AEE PiTo Gas) eam ams mmses cena 5 1%) gE S3SAR gREZR EEE q3 i3 | on mena ii SINR |r wo : Ha aa g 3 d |:EoeE; BEeRnNeE Ea nana ham ME i]. 2283 ; gEgse ; g3EEE . 233d i i | fr pear mann aan % | 33 dgga seas sees : | gEE mE IME oamEm =) nnoen min om i h-t4-44 EXERT Iaxas sEEIT i$a | A--_3--33 NARa%aEsE 0 gmEaAnR IrEE--E Toe mm ammo 1| me ore mm mm Iai --- 11Ti IE ano osm mam @% [I %| dmoBmE och SIM : foc Eo: i | EERIE Eg aE 2 g| % goss | mgege : ggaes 2 ness 2 &2 : 8 tx i] Dmgny [geen | SESS y YEAR HH ii i i ~i3 | rrr ETT ETT Gomtny Santas. Goss nco ontTSCiA CnE1 ~4 3 ~| i j{i1 ii : 8| 533% 3333d | E333T g 33E33 Br Tem ummm ten 1 i | LERRE BERR. GHEE: ESM Ri 23 8 iB| ] i; 392838% i; o3d3d3:2 i. 3C2E3E3E3E i, 2L3L3L3E3S : Sn pm | EEE NE gg| gesaereeer EERE cgpeeseens 7 Hig GE ,| iy 338833888: SgSuuRgan: 3 ix i | samme me Dov) a z | ERE | LEER {OUTER RE | EGG | [RR NNR I 328388388 3338338833 : fr HP ER i Dov | : ; I g BEREENENS 3 SERRRRRRER 2 : 8 58! 3] 339389348 > fiisisissE ~ 52 ~i & gd : EE 7 3 | &g & I ; z33 go eT ie8 _ggal =8 . az 84| 7 temsgergan panasaggsas ga| zFagmosanans gngsusesas i15 | 8 sZs3r8e3sasaszsessss | scsezseiaisisiaisfey 2| ; IITITITIIT i5 ITIITILIIIT [---- PR i i3 :3 [ i Ii id H 2 i: i E83 i : g i | :8 sgrgasssng 3 geeageeace g : 2 >243] el && szssneeeee :#2 wonomooens ~33 : : CompanySantas. boo ro continT5CA GOI - 2 Sassgeessr smmsprese 3 | HEE 2 | FEA RR | Poi | EEE EE | IWEBGW EEL ol 2585358358 3538%aEE ] i 833808R333 cRplatEess HI H FR ren f2 8i |5 wana 3dunn 5: 2" EBEEEBUEEY E SHESddise i 25 25 ||:oaG mmmiremene 5 oSrReIeRsHeInEeInEeS -~33 3 3 Company Satz.bos eco5 n01 - ? 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Does not contain TSCA C81 910.2.4D7a6y6:GaSvuabgeehvSotruidyc TinoxRiacittywith One-Generation Reproduction Evaluations DuPont5990 INDIVIDUAL BIOCHEMICAL MEASUREMENTS IN MALE RATS ATTHE 10-DAY TIME POINT Animal Beta-Oxidation Rate Group Number __(nmol/min/mg protein) 1 648938 33 648939 16 648940 37 648041 41 645942 50 m 645943 41 648944 38 648945 38 645946 51 645947 32 v 648948 55 _ 648949 33 648950 62 648951 75 648952 75 vi 648953 28 648954 128 648955 124 648956 135 648957 87 mS Company Saniized. 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Does not contain TSCA CBI 9H0.2-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BIOCHEMICAL MEASUREMENTS IN MALE RATS AT THE 1-MONTH RECOVERY TIME POINT Group 1 vi Animal ~~ Beta-Oxidation Rate Number __(nmol/min/mg protein) 646459 72 646460 63 646416 58 646371 62 646411 66 646364 149 646384. 11.1 646474 100 646448 122 646484 144 INDIVIDUAL BIOCHEMICAL MEASUREMENTS IN MALE RATS -~ AT THE 3-MONTH RECOVERY TIME POINT Group 1 vi Animal Number 646325 646396 646495 646468 646355 646344 646361 646391 646466 Beta-Oxidation Rate __(nmol/min/me protein) 17.6 192 176 196 207 183 200 179 172 -- w= Company Sanitized. 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Does not contain TSCA CBI H-24768; SubchronicToxicity '90-Day Gavage Study in Rats with One Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BIOCHEMICAL MEASUREMENTS IN FEMALE RATS AT THE 1-MONTH RECOVERY TIME POINT Group id vin Animal Number 646580 646581 646627 646565 646551 646540 646548 646508 646650 646637 Beta-Oxidation Rate __(nmol/min/mg protein) 10.5 82 9.1 12 104 133 12 15.9 1n2 13.5 - `Company Sanitized. Does not contain TSCA CBI 9H0-2-4D7a6y8:GavSaugbeehSrtoundiyc iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont5990 APPENDIX M INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS -- ee Company Sanitized. Doas not contain TSCA C81 ~ : {3 imareeegmn 3iessmaensl Poo Blesserens a Enda BBEo| | iDSEgzRRaEecEazRe L 3n E |. eeE vsnR n. fee igiiq ilyfBilgdegaiscmdpgsaansdss =A8tii |(gfBiiaggsesAunnsssasri 3BgEEiRp paEtEaInEiNtEeNnEn aEnLi BSspep evei ee. 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Doesnot conTtSaCAiCBnI H9-02.4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywith One-Generaion Reproduction Evaluations DuPon:5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS EXPLANATORY NOTES LESION GRADING: CHhiasrtaocptaetrh,olodgiisctarlibucthainognesanadresedveersictryi.bedTahcecodridsitnrgibuttoiotnhei(rexmtoernpthoolfogtiicssue mSualvtoilfvoecmaeln,t) diifsfuisned.icautneidl,atewrhaelr,e abiplpartoeprraila,te,etcb.y moAdisfeiveerrsitysucshcoraes, fiofcal, appropriate, is also assigned as follows. MINIMAL: IL: MODERATE: SEVERE: cThoensaimdoeurnetd tofo cbehawnigtehipnresneonrtmalbarleilmyitsexceeds that which is Isnevegreinteyr.al, `Tthheelelseisoinonprisobeabalsyildyoeisdennottifiperdodbuucte oafnylifmuinctteidonal impairment. Tihnecrelaesseidon seivserpirtoym.inenLtimbiuttedthteirsesueisorsigonrigfaincadnytsfpuontcetnitoinalis for possible. Tohregrdeeagtreeenoofughchainngeintisenseiitthyerorasextceonmtplettoeexaspecctonssiidgenriefdicapnotssible tissue or organ dysfunction. comment: Garcaodenstinmuinuimmawliththmrionuignhalsevleerseionrsepbreesienngt tpheroglreeasstsivseeveirnevoalnvdemesenvte/rseevelreistiyonsalong bcehianrgacttehreimsotsitcsseovferle.esionWsh,ilethtehyealgsroadeisndirceafteer ttoheitrhermeolrapthiovleogbiicoallogical significance. Glreotstsersobs(eir.vc.a.tioA,nsb,lics,tin4,g emtucl.t)i.ple masses for a tissue are distinguished with 826 Company Sanitized. Does not contain TSCA Cal F9-02-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPont:5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day sex: wales Animal Ref Microscopic & Macroscopic Findings 646325 KTeirlmliendalonSaDcary:ific1e83 AEnxipmoaslureisGrsoiugpned: 3of-fMonftrhomRenceocvreorpysy Gross pathology . No MaLIcVrEoRs,copKiIcDNEAYbSn,orSmPaLlEiEtNy, ObTsHeYrRvOeIdD G: LAND, PARATHYROID GLANDS, TESTES Histopathology LIVER:FATTY CHANGE, PERIPORTAL, minimal KIDNEY`NSEP:HROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSESOAFCRDIEFAITCHE B: Y DESIGN. No MiScPrLoEEsNc,opiTcHYRAObInDorGmLaAlNiDty Observed --- 646360 TKeirlmliendalon sDaacyri:fic9e5 AEnxipmoaslureisGrsoiugpne:d o9f0f-DafyromExnpeocsruroepsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKELETAL WUSCLE, SPLEEN, AIOLRETUAM., PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDNST,IC`MNAENRDVIEB,ULPAIRTULIYTMAPRHYNOGDLEA,ND,THYMUS, 646360 Continued on the next page -... CompanySanitized. Does not containTSCACBI 9H02-4D7a6y8:GavSaubgeehSrtoundiyc TinoxRiactistywith OneGeneration Reproduction Evaluations DuPont-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646360 Continued from previous page Gross Pathology No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDeGrLvAeNdDS:, TRACHEA, ESOPHAGUS. SPEHMAIRYNNAXL/LVAERSYINCXL,ES,EVEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE v Histopathology + HEARTCA: RDIOMYOPATHY, minimal. THYROAILDTEGRLAATNIDON:, COLLOID, minimal. CAUSESOAFCRDIEFAITCHE BY DESIGN. No MiLcIVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OSbKsEeLrEvTeAdL M: USCLE, SPLEEN, AORTA, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH INLOEDUEM,, - GSLAALNIDVSA,RYSGCLIAANTDISC, NEMRAVNED,IBUPLIATRUITLYAMRPYHGLNAONDDE,, TPHAYRNAUTSH,YRAODIRDEGNLAALNDS, PERSOOSPTHAATGEU,S, SEPHMAIRNYANLX/VLEASRIYCNLKE,S, EYUER(ISN)ARYWITBHLADODPETRI,C TNEERSVTES,, SKIN, TEP&IDIIDI,VMINDOESSE, IIFIEN&UR/IKVNEE JOINT, STERNUM, BONE MARROW, NOSE -= `CompanySanitized. DosnotconTtSaCAiCBnI H9:02-4D7a6y8:GavSaugbcehSrtoundiyc TinoxRiactistywithOne-Generation Reproduction Evaluations DuPont 5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day sex: wales Animal Ref Microscopic & Macroscopic Findings 646367 TKeirlmliendalon SaDcaryif: ic9e6 AEnxipmoaslureisGrsoiugpne:d o9f0f-DafyromExnpeocsruorepsy Gross pathology No MaLIgVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt.y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCAECLUMC,ORDC.OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRVOIIUD/LGALRAYNND,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA.TE, FSEEMMIUNRA/LKNVEEESIJCOLIENST,, SUTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES Histopathology THYRO`IADLTGELRAANTDION, COLLOID, minimal. - CAUSE`SOAFCRDIEFAITCHE B Y DESIGN. No MiLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC.OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE.NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, PUEYRAEIR(NASAT)RHYYWRIOBLTIAHDDDGOELPRAT,NIDCST,ENSETRTEVRSEA,,CHEESAKP,IIND,IEDSYOPMPRIHODASEGTSUA,ST,E,FEPMHSAUERRMY/INKNKAN/LELEAVREJYSONIIXNC,TL,ES, STERNUM, BONE MARROW, NOSE I & IT, NOSE ITT & IV Ti `Company Sanitized. Doesnot containTSCA C81 'H9-02-4D7a6y8:GaSvuabgeehrSotnudiyc Toxicity in Rats with One.Generation Reproduction Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: males Animal Ref Microscopic & Macroscopic Findings 66371 KTeirlmliendalon SaDcaryif: ic1e23 EAnxipmoaslureisGrsoiugpned: o1f-fMonftrhomRenceocvreorpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUIYTMAPRHYNOGDLEA,ND,THYMUS, TPHHYARROYINXD/LGALRAYNND,K, `EPAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNVEEESIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology : THYROIADLTEGRLAATNIDON. COLLOID, minimal - CAUSE`SOAFCRDIEFAITCHE B Y DESIGN. No MiLIcVrEoRs,copKiIDcNEAYbSn,ormSaPlLiEtEyN Observed : 50 Company Sanitized. Donotecontsain TSCA CBI H9-02-4D7a6y8G:avSaugbcehSrtoundiyc TinoxRiactistywith One-Generaton Reproduction Evaluations DuPont5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: males Anical Ref Microscopic & Macroscopic Findings 46374 TKeirlmliendalonSaDcaryif: ic9e5 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsruroepsy Gross pathology No maLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, IALOERUTMA,, PBRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODNEENSUEMN,TERJIEJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDNST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYOVINDX/GLLAARNYDN,K, PAEYREA(TSH)YROWIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMNIUNRA/LKNVEEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology LIVERINFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. - spreeINFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal PANCREIANSFLA:MMATION, SUBACUTE/CHRONIC, FOCAL, minimal THYROAILDTEGRLAATNIDON:, COLLOID, mild. CAUSESOAFCRIDFEIACTEH BY DESIGN. 646374 Continued on the next page .... THis Company Sanitized. Does notcontainTSCACBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Ras withOneGeneration Reproduction Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 66374 Continued trom previous page Histopathology : No MiKcIDrNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y SOKbEsLeErTvAeLd M: USCLE, AORTA, BRAIN, CSOPLIONNA,L RCOERCDT,UM,STOMMEASCEHN,TERDIUOCDELNYUMMP,H NJOEDJEU,NUMS,ALIIVLEAURMY, GLCAENCDUSM,, + NMEARNVDEI,BULPAIRTUILTYAHRPYH GNOLDAEN,D, THPYAMRUAST,HYARODIRDENGALLANGDLSA,NDST,RACSHCEIAA,TIC EPSROOPSHTAAGTUES,, SEPHMAIRNYANLS/VLEASRIYCNLXE,S, EYUER(ISN)ARWYITBHLADODPETRI,C TNSESRTVEES,, SKIN, ETP&IDI1D1,YNINDOESSE, IIFTEM&UR/IKVNEE JOINT, STERNUM, BONE MARROW, NOSE 646379 TKeirlmliendalon SaDcaryif: ic9e5 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsruorepsy Gross pathology - No waLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedS:KELETAL MUSCLE, SPLEEN, IALOERUTMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC.TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANDODREE,NALSALGILAVNADRSY, GLSACNIDAST,IC MNAENRDVIEB,ULAPRITLUYIMTPAHRY NGODLEA,ND,THYMUS, TPHHYARROYINXD/LGALRAYNNDK,, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, 646379 Continued on the next page . 532CompanySanitzed. Doesnot conTtSaCAiCBnI 9H02-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPon-5990 . INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 ma/ka/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646379 Continued from previous page Histopathology LIVERI:NFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. PANCREHAYSPER:TROPHY, CENTRILOBULAR, minimal. THYROIIDNFLGALMAMNADTI:ON, SUBACUTE/CHRONIC, FOCAL, Minimal. PARATAHLYTREORIADTIGOLNA,NDSCOL:LOID, minimal. CAUSEMIOSFSIDNEGA.TH SACRIFICE BY DESIGN No miKcIrDNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y OSbKsEeLrEvTeAdL M:USCLE, SPLEEN, AORTA, CBERCAUIMN,, CSOPLIONNA,L CROERCDT,UM,STMOMEASCEHN.TERDIUOCDELNYUMMP,H NJOEDJEU,NUMS,ALIIVLEAURMY. GSLCAINADTSI,C NMEARNVDEI,BULPAIRTULIYTMAPRHY GNOLDAEN,D, THTYRMAUCSH,EA,ADREESONPAHLAGGULSA.NDS, - . SPHEAMRIYNNAKL/LVAERSYINCKL,ES,EYEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, rFEMeUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE ORGANPSARNAOTTHYREXOAIMDINGELDA:NDS -= `Company Sanitized. Donotocontsain TSCA Cal H902-4D7a6y8:GavSaubgcehSrotnuidcy TinonRiactistywith One.Generation Reproduction Evaluations DuPont5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: I- 0 mg/ka/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646396 TKeirlmliendalonSaDcaryif: ic1e83 EAnxipnoaslureisGrsoiugnpe:d o3f-fYonftrhomReneccorvoeprsyy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormSPaLlEiEtNy, ObTsHeYrRvOeIdD G: LAND, PARATHYROID GLANDS, TESTES Histopathology LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal KroNEYNsEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSESOAFCRDIEFAITCHE B: Y DESIGN. No MiScPrLoEEsNc,opiTcHYRAObTnDorGmaLlAiNtDy Observed - 646398 TKeirlmliendalonSDaacyrif: ic1e23 AEnxipnoaslureisGrsoiugpned: o1f-fYonftrhomRneeccorvoeprsyy Gross Pathology No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB.ULAPRITULYIMTPAHRYNGODLEA,ND.THYMUS, 546398 Continued on the next page -.. -== `Company Sanitized.Doesnotcontain TSCA GBI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646398 Continued from previous page Gross pathology No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDerGvLAeNdDS, TRACHEA, ESOPHAGUS, SPHEAWRIYNNAXL/LVAERSYINCXL,ES,EVEU(RSI)NARWYITHBLAODPDTEIRC, NTEERVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE . Histopathology LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. CAUSE`SOAFCRDIEFAITCHE BY DESIGN No MiKIcDrNoEsYcSo,picSPLAEbEnNo,rmTaHlYiRtOyIODbGsLeArvNeDd : saga11 - TKeirlmliendalonSaDacyr:ific1e23 AEnxipmoaslureisGrsoiugpned: o1f-fNonftrhomRneeccorvoeprysy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR.EASS,PICNEACLUMC,ORDC.OLOSNT.OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS. 646411 Continued on the next page ... -= CompanySaitized. Doesnot conTtSaCAiC8n1 H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with OneGeneration Reproduction Evaluations DuPont5990 - TNDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group I- 0 mg/kg/day sex: males Animal Ref Microscopic & Macroscopic Findings Gaga1l Continued from previous page Gross Pathology No maTcHYrRoOsIcDopGiLcANADb,norPmAaRlAiTHtYyROOIbDseGrLvAeNdDS:, TRACHEA, ESOPHAGUS, SPHEAMRIYNNAXL/LVAERSYINCKLE,S,BYEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology + KoNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSE`SOAFCRDIEFAITCHE B: Y DESIGN. No MiLIcVrEoRs,copSiPcLEEANb,noTrHmYaRlOiItDy OGLbAsNeDrved : 646416 - TKeirlmliendalonSaDcaryif: ic1e23 AEnxipmoaslureisGrsoiugnped: o1f-fMonftrhomRenceocvreorpysy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THAMUS, 646416 Continued on the next page .... = -_-- `CompanySanitized. Doesnotcontain TSCAC81 9H0-2-4D7a6y8:GavSaugbehrSotnuidcy iTnoxRiactistywith OneGeneration Reproduction Evaluations DuPont-5990 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day sex: Males Animal Ref Microscopic & Macroscopic Findings 646416 Continued from previous page Gross Pathology : No MaTcHYrRoOsIcDopGiLcANADb,norPmAaRlAiTtHyYROObIsDeGrLvAeNdDS:, TRACHEA, ESOPHAGUS, . 'PSHEAMRIYNVANLX/VLEASRIYCNLKE,S,EYEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal THYROAILDTEGRLAATNIDON, COLLOID, minimal. CAUSE`SOAFCRDIEFAITCHE B Y DESIGN No MiscerLoEsEcNopic Abnormality Observed 646420 KTeirlmliendalonSDaacyrif: ic9e5 AEnxipmoaslureisGrsoiugpne:d o9f0f-DafyromExnpeocsruroepsy Gross Pathology URINARCYALCBULLAUDSD\ECRAL:CULI, severe. COAGULLAARTGIEN,G GLLEFATN,DSsevere, 646420 Continued on the next page .... `CompanySanitized.Doesnot contTSaCAiCnBI H0.-2D4a76y8:GaSvuabgcehrSotnuidcyTionxRiactistywith One-Generation Reproduction Evaluations DuPont5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Pose Group: I- 0 mg/kg/day sex: wales Animal Ref Microscopic & Macroscopic Findings 646420 Continued from previous page Gross pathology No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN. ATOLRETUAM!, BPRAANICNR,EASS,PICNEACLUMC,ORDC.OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN.TERJIEJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC`NMEANRDVIEB,ULPAIRTLUYIMTPAHRYNOGDLEA,ND.THYMUS. TPHHYARRYONIED/LGALRAYNND,K, PEAVREA(TSH)YRWOIITDHGOLPANTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA.TE, `SSTEEMRINNUAML, VNEOSISCELES, TESTES, EPIDIDYMIDES, FENUR/KNEE JOINT, Histopathology LIVERFA: TTY CHANGE, PERIPORTAL, minimal. FIANTFTLYAMMCAHTAINOGNE,, SMUEBDAICAUNTEC/LCEFHTR,ONImCi,nimFaOlCAL, minimal. KIDNEYPSYELONEPHRITIS, BILATERAL, mild --_ THYRO`IADLTGELRAANTDION, COLLOID, mild. PROSTAITNFELA:MMATION, SUBACUTE/CHRONIC, moderate. SEMINAILNFLVAEMSMIACTLIEOSN,: SUBACUTE/CHRONIC, mild. URINA`RCYALBCLUALUDSD/ECRAL:CULI . HIYNPFELRAPMLMAASTIIAO,N, TRSUABNASCIUTTIEO/NCAHLROCNEILCL,, mmioldde.rate. CAUSESOAFCRIDFEIACTEH B: Y DESIGN. 646420 Continued on the next page . -= -- Company Sanitized.Dossnot contain TSCA C81 9H02-4D7a6y8:GaSvuabgeehrSotnudiyc iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646420 Continued from previous page Histopathology No MCiLOUcRNrDGo,Ss,co"SpHTEiOAcMRATAC,Hb,noSrDKmUEGaLDlEEiTNtAUyLM,MOUbSJsCEeLJrEUv,NeUdMS,P:LEIELNE,UM,AORPTAAN,CREBARSA,IN,CECSUPMI,NAL CMNEOARLNVODENI,,BULPRAEICRTTUUILMTY,AMRPYHMENGSLOEADNNETD,E,RTIHCPYAMLRUYASNT,PHHYRAODNOIRDDEEN,GALLASNAGDLLSAI,NVDASRT,YRACGSHLCEAIANA,DTSI,C TMEEASSROTRPEOHSWA,,GUSNE,OPSIEDPIHDAIYRM&YINDXIE/IS,L,ARNYOFNSEXEM,URIE/IIYKEN(E&SE)IJVOWIINTTH, OPSTTIERCNUNME,RVEB,ONESKIN, 646427 TKeirlmliendalonSaDcaryif: ic9e5 AEnxipmoaslureisGrsoiugnped: o9f0f-DafyromExnpeocsruorepsy Gross Pathology ~ No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, AORTA! BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, NAIODLDEREUE,MN,AL"SPAGALLNIACVNRADERSAY,S,GL`ASCCNEIDCASUT,MI,CMNCAEONRLDVOINEB.,ULARPREICTTLUUYIMMT,PAHRYMENGOSDLEEAN,NTDE,RTIHYCMULSy,MPH `PTHHAYRRYONIXD/LGALRAYNND,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC.HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNVEEESIJCOLIENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, 646427 Continued on the next page . _-- ETN CompanySanitized. DoesnotconTtSaCAiCBnI F9-02-4D7a6y8:GaSvuabgcehrSotruidcy iTnoxRiactistywithOneGeneration Reproduction Evaluations DuPon5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646427 Continued from previous page Histopathology + LIVERFA: TTY CHANGE, MEDIAN CLEFT, minimal . KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal PROSTAITNEFLAIIATION, SUBACUTE/CHRONIC, minimal . CAUSESOAFCRDIEFAITCHE BY DESIGN. No miLUcNrGoSs,copHiEAcRTA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL CCMOOARLNDOD,NI,BU"LSRTAEORCMTAUCLMHY,,WPHMDEUSONODEDENENT,UEMR,ITCHYJMELUJYSUM,NPUHMA,DNORDETENL,AECLMS,GALLAIPNVADANSCR,RYEAGSSLC,AINNDTCSIE,CCUM, NTERRAVCEH,EA,PIETSUOIPTHAARGYUSG,LANPDH,ARYTNHKY/RLOAIRDYNGYL,AND, PARATHYROID GLANDS, BEYLEA(DSD)ER,WITTEHSTOEPST,ICENPEIRDVIED,VWISDKEISN,, FSEEMMUIRN/AKLNEVEESIJCOLIENST,, USTREIRNNAURMY, BONE MARROW, NOSE I & II, NOSE III & Iv 646432 TKeirlmliendalonsDaacyr:ific12e3 AEnxipmoaslureisGrsoiugpne:d o1f-fMonftrhomRenceocvreorpysy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, ANIOOLDREETU,AM., "SBPARALANIICVNRA,ERAYSS,PGLIACNNEADCLSU,MC,ORMDAC,ONLDOISNTB.OUMLAARCREHC,TLUYMMD,PUOHDMEENNOSUDEMEN,,TETRJHIEYJCMUUNLSUM,MP,H 646432 Continued onADtRhEeNAnLextGLApNaDgSe, SCI-. ATIC NERVE. PITUITARY GLAND, _--_ 80 Company Sanitized.Doesnot conTtSaCAiCBnI 'H9204-7D6a8y:GavSaubgeehSrtoundiyc TinoxRiactistywithOneGeneration Reproduction Evaluations DuPon-5990 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day sex: Males Animal Ref Microscopic & Macroscopic Findings 646432 Continued from previous page Gross Pathology : No M`aTcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROOIbDseGrLvAeNdDS:, TRACHEA, ESOPHAGUS, FPSHEEAMMRUIYRNN/AXKL/NLEVAEERSYIJNCOKLI,ENST,,EYESU(TRSEI)RNNAUWRMIY,THBNLAOODSPDETEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, Histopathology + KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal THYROAILDTEGRLAATNIDON, COLLOID, minimal. CAUSESOAFCRDIEFAITCHE BY DESIGN No MiLIcVrEoRs,copSiPcLEEANbnormality Observed : -_ 6a6ass TKeirlmliendalonSaDcaryif: ic1e23 AEnxipmoaslureisGrsoiugpned: o1f-fNonftrhomRenceocvreorpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHbEAsReTr,vedSKELETAL MUSCLE, SPLEEN, ANIOOLDREETU,MA,. 'SBPARALANTICVNRA,ERAYSS,GPLIACNNEADCLSU,MC,OR`DMC,AONLDOSINTB,OUMLAARCREHC,TLUYMMD,PUHODMEENNOSUDEMEN,,TERJTIHEYJCMUUNLSUY,MM,PH 646446 Continued onADthReENnAeLxtGLApNaDgSe, .S..C.IATIC NERVE. PITUITARY GLAND, -_-- we `CompanySanitized. Doesnot conTtSaCAiCBnI H24768: Subchronic Toxicity 90.Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: Hales Animal Ref Microscopic & Macroscopic Findings 6a6a16 Continued from previous page Gross Pathology No M`aTcHrYoRsOcIoDpiGcLANADb,norPmAaRlATiHtYyROOIbDseGrLvAeNdDS, TRACHEA, ESOPHAGUS, . PSHEAMRIYNNAXL/LVAERSYINCKL,ES,EYEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal THYROIADLTEGRLAATNIDON:, COLLOID, minimal cAvSESAOFCRDIEFAITCHE BY DESIGN No MiKcIrDNoEsYcSo,picSPLAEbEnNormality Observed --_ 646457 DUunrsacthieodnuleofd dSoascirnigf-idcaeys: 57 AEnxipmoaslureisGrsoiugpne:d o0f-fDafyromExnpeocsurroepsy Gross Pathology sky:STAIN, RED, VENTRAL BODY, WET. URINARDYILABTLAATDIDOENR, RED, severe 646457 Continued on the next page .. - = CompanySanitized.Does notconTtSaCAiCnBI F9-02-4D7a6y8:GaSvuabgcehrSotnuidcy iTnoxRiactistywithOne:Generation Reproduction Evaluations DuPont-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 6a6a57 Continued from previous page Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NAL'SAGLLTAVNADRSY, GL`ASCNIDAST,IC`WNAENRDVIEB,ULPAIRTLUIYTMAPRHYNOGDLEA,NDTHYMUS, `PTHHAYRRYONIYD/LGALRAYNND,K, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRAVEC,HEAP,ROSETSAOTPEH.AGUSSE,MINAL VNEoSsIeCLES, TESTES, EPIDIDYNIDES, FEMUR/KNEE JOINT, STERNUM, Histopathology : KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, mild URINARIYNFLBALMAMDADTEIRON, SUBACUTE/CHRONIC, mild. CAUSEHOEFMORDREHAATGHE,+ moderate - KIDNEY: INFLAMMATION/OBSTRUCTION. No MiLcIrVEoRs,copLiUcNGSA,bnoHrEAmRaTl,itySKOEbLsEeTArLvedMUSCLE, SPLEEN, AORTA, BRAIN, CSEPCIUNMA,L CCOORLDO,N, STROENCATCUHM,, DMUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODTEL,EUMS,ALPIAVNACRRYEAS, GSLCAINNDTSI,C MNEARNVDEI,BULPAIRTUILTYAMRPYH GNLOADNE,D, THTYHMYURSO,IDAGDLRAENNDA,L GLANDS, EPYAER(AST)HYWRIOTIHD OGLPATNIDCS,NERTVREA,CHESAK,IN,ESOPPRHOASGTUAST,E, PSHEAMRIYNNAXL/LVAERSYIXC,LES, TMEASRTREOSW,, ENPOISDEIDIYM&IDIETS,, NOFSEEMURI/TIKN&EEIJVOINT, STERNUM, BONE -- we CompanySanitized. DoesnotconTtSaCAiCnBI 'H9204-7Da6y8:GavSaugbeehSrtoundiyc iTnoxRiactistywith OneGeneration Reproduction Evaluations DuPoni-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646459 KTeirlmliendalonSaDcaryi:fic1e23 r EAnxipmoaslureisGrsoiugnpe:d o1f-fMonftrhomRneeccorvoeprysy Gross pathology No MaLcIrVEoRs,copKiIcDNEAYpSn,orLmUaNlGiSt,y OHbEAsReTr,vedSKELETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC.OLOSNT.OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GL`ASCNIDAST,IC`MNAENRDVIEB,ULAPRITLUYIMTPAHRYNGODLEA,ND,THYMUS, TPHHYARRYOWICD/LGALRAYNND,X, PEAVREA(TSH)YROWIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology LaverINFLAMMATION, SUBACUTE/CHRONIC, FOCAL. minimal. - THYROAILDTEGRLAATNIDON, COLLOID, minimal CAUSESAOFCRIDFEIACTEH BY DESIGN. No MiKIcDrNoEsYcSo,picSPALbEnENormality Observed : --_-- re ---- `Company Sanitized.Doesnot conTtSaCAiCnBI 9H-02-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: I- 0 mg/kg/day Sex: Hales Animal Ref Microscopic & Macroscopic Findings 646460 KTeirlmliendalonSDaacyrif: ic12e3 EAnxipmoaslureisGrsoiugpned: o1f-fMonftrhomRenceocvreorpysy Gross pathology . No MaLAOIcRVrTEoARs.,copKBiRIcADINNEA,YbSn,oSrPmILaNUNAlGLiSt,CyORHODEb,AsReTrS,vTOeMdSAKCE:HL,ETADLUODMEUNSUCML,E, JESJPULNEUEMN,, . NAIODLDREEUE,MN,AL"SPAGALLNIACVNRADERSAY,S,GLSACCNEIDCASUT.MI,CMCNAEONRLDVOIENB,.ULAPRREICTTULUIYMTM,APHRYMENGOSLDEEAN,NTDE,TRHIYCMULSY,MPH TSPHEHYMARIRYONNIAXDL/LGVALERASYNINDCK,L,ES`,PEAYREUA(RTSIH)NYARRWOYIITDHBLGAOLDAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIENPE,ISDOIPPHDRAYOGMSUITSDA,ETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : CAUSE`SOAFCRDIEFAITCHE B: Y DESIGN --_ No MiLIcVrEoRs,copKiIDcNEAYbSn,ormSaPLlEiEtNy, OTbHsYeRrOvIeDd GLAND 646468 TKeirlmliendalonsDaacyrif: ic1e83 EAnxipmoaslureisGrsoiugpn:ed o3f-fMonftrhomRneeccorvoeprsyy Grose Pathology No MaTLIceVsrEToREs,ScopKiIDcNEAYbSn,orSmPaLlEiEtNy, ObTsHeYrRvOeTdD GLAND, PARATHYROID GLANDS, 646468 Continued on the next page . --- Tass `CompanySanitized.Does not conTtSaCAiCBnI 9H0L2-4D7a6y8:GavSaugbcehSrtounidcy iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings sa6a6s Continued from previous page Histopathology : KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSESAOFCRIDFEIACTEH BY DESIGN No MiLIcVrEoRs,copSiPLcEEANb,noTrHmYaRlOiItDy OGLbAsNeDrved : 646482 TKeirlmliednalon saDcaryif: ic9e5 AEnxipmoaslureisGrsoiugnped: o9f0f-DafyroEmxnpeocsruorepsy Gross Pathology : No MaALOcIRVrTEoARs,,copBKiRIADcINNEA,YbSn,oSrPImLNUaANlGLiSt,CyORHODEb.AsReTrS,TvOeMSdAKCEHL,ETDAULODMEUNSUCNL,E,JESJPULNEUEMN,, --_ ANIDOLDREEUE,MN,A|SLAPLGALINACVNRADERSAY,S.GLSACCNEIDCASUT,MI,C`MCNAOENLRDOVINEB.,ULRPAEIRCTTLUUIYMTM,APRHYMNEOGSDLEEAN,NTDE,RTHIYCMULSY.MPH STPEHHMYAIRRNYOANIKLD/LVGALERASYNIDNC,KLE,S`,EPYAREUA(RTSIH)NYARWROIYITDHBGLLAOADPNDTDEISRC,, NTTEERRSAVTEC,EHSE,AS,KIENPE,ISDOIPPDHRYAOMGSIUTDSAE,TSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology 646482 ContinueKdIDoNnEYNSEtPhHeROnPeAxTtHYp,agCeHR.O..NIC PROGRESSIVE, minimal a6 `CompanySanitzed.Doesnotcontain TSCA Ca1 9H-02-4D7a6y8G:avSaubgeehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont 5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 6a6us2 Continued from previous page Histopathology PARATMHIYSRSOIINDG.GLANDS : CAU. SESAOCFRIDFEIACTEH B: Y DESIGN. No MiLSIcPVrIEoNRsA,cLopLCOUiRNcDG,SA,bnSToHOErMAmRAaTCl.Hi,tySDKUOEObLDsEEeTNArULvMe,MdUSJCELJEU,NUMS,PLEIELNE,UM,AORPTAAN,CREBARSA,IN, `CSGECLCIAUANMTD,SI,CC`NOMELARONVNDE,I,BRUEPLCIATTRUUMLI,YTMAPRMHYESGENLONADTNEE.DR,ICTTHYHLMYYURMSOP,IHDANDGODLREAE,NNDA,LSAGTLRLIAAVCNAHDRESYA,, EPERSPOOISPDTHIAADTGYEUU,SI.DESSEP,MHIANRFAYELNNKU/VRLE/ASKRINYCENLEXE,SJ,OIENYUTER,(ISN)ASTREYWRINTBUHLMA,DODPETBRIO,CNENTMEEARSRVTREE,OSW,,SKINNO,SE I&II, NOSE IIT & Iv ORGANPSARNAOTTHYREOXAIMDINGELDA:NDS - 646485 TKeirlmliendalonSaDcaryi:fic95e AEnxipmoaslureisGrsoigunpe:d o9f0f-DafyroEmxpnoescurroepsy Gross Pathology No MaALOIcRVrTEoARs,,copKBiRIcADINNEA,YbSn,SoPrILmUNaNAlGLiSt,CyOROHDEb,AsReTrS,vTOeMdSAKCE:HL,ETADLUODMEUNSUCML,E, JESJPULNEUEMN,, ANIDOLDREEUE,MN,A'LSAPGLALINACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMANCEONRLDVOINEB,,ULARPREICTTLUUYIMMT,PAHRYMENGOSDLEEAN,NTDE,RTIHYCMULSY,MPH 646485 Continued on the next page . _--m-- CompanySanitized. Doesnot contain TSCACBI 9H0-2-4D7a6y8:GavSaugbcehSrtoundiycTionxRiactistywith One Generation Reproduction Evaluations DuPont-5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646485 Continued from previous page Gross Pathology No M`aPTcHHrAYRoRYsONcISoD/pLiGAcLRAYNANDb,Kn,orPEmAYaRElA(TiSHt)YyRWOOIIbTDsHeGrLOvAPeNTdDISC:, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMUIRN/AKLNEVEESIJCOLIENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYNIDES, Histopathology LiverINFLAMMATION, KIDNEYS SUBACUTE/CHRONIC, FOCAL, minimal. `THYRONIEDPHGRLOAPNADTH:Y, CHRONIC PROGRESSIVE, minimal. PROSTAALTTEERATION, COLLOID, minimal. CAUSEIONFFLDAMEMAATTHION, SUBACUTE/CHRONIC, mild. `SACRIFICE BY DESIGN. -_ No MiCLOUcRNrDGo,Ss,co"SpHTEiOAcMRATAC,Hb,noSrDKmUEOaLDlEEiTNtAUyLN,OMUbSsJCEeLJrEUv,NeUdMS,P:LEIELNE,UM,AORPTAAN,CREBARSA,IN,CECSOPMI,NAL NCHEOARLNVODENI,,BULPRAEICRTTUULIMYT,MAPRHYMEGNSLOEADNNETD,E,RTIHCPYAMRLUAYSMT,PHHYARDNOORIDEDEN,AGLLASNGADLLSAI,NVDASTR,RYACGSHLCEAIANA,DTSI.C FESESEMOMUPIHRNA/AGKLUNSEV,EESIJPCOHLIAENRSTY,,NX/USLTRAEIRRNYNAUNRMKY,, BLEBAYODEN(DESE)RM,ARWRITOETWSH,TEOSPN,TOISCEEPIN1DEIR&DVYE1,M1I,DSENKSIO,NS,E mI ev ------------ `Company Sanitized. Doesnot conTtSaCAiCnBI 9H0-2-4D7a6y8:GavSuabgeehrSotnuidcy TinoxRiactistywith One.Generation Reproduction Evaluations DuPont5950 -_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 6a6487 TKeirlmliendalonSaDcaryif: ic1e23 AEnxipmoaslureisGrsoiugpned: o1f-fMonftrhomRencecorvoeprsyy Gross Pathology + No MaLcIrVEoRs,copKiIcDNEAYbSn,orpLaUNlGiSt.y OHEbAsReTr,vedS:KELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS.PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TEJREIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYWUS, TPUHYARROYINDX/LGALRAYNDN,E, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology CAUSESOAFCRIDFEIACTEH B: Y DESIGN - No MiLIcVrEoRs,copKiIcDNEAYbSn,ormSPaLlEiEtNy, ObTsHeYrRvOeIdD G: LAND 9 Company Sanitized.DoesnotconTtSaCAiCBnI 9H0--2D4a7y68G:avSaubgeehSrtoundiyc TinoxRiactistywith One Generation Reproduction Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/ka/day Sex: wales Animal Ret Microscopic & Macroscopic Findings 646489 TKeirlmliendalonSaDcayri:fic9e5 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsruorepsy Gross Pathology : . No Ma`LcxrvoesR,copKiIDcNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, AORTA. BRAIN, SPINAL CORD. STOMACH, DUODENUM, JESJPULNEUEMN,, NTOODEEO,M, SAPALNICVRAERAYS,GLACNEDCSU,M, MACONLDOINB,ULARRECTLUYMM,PHMENOSDEEN,TERTHIYCMULSY,MPH ATPDHHRYAERRNOYANIULD/LGGALLRAAYNNNDD,KS,, PSEAYCREIA(ATSTH)IYCRWONIIETDRHVGELO,APNTDIPSCI,TUNTEIRRTAVAECR,HYEAGS,LKAINNE,DS.OPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEEESIJCOLIENST,, SUTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, Histopathology PANCREIANSFLA YMATION, SUBACUTE/CHRONIC, FOCAL, minimal. - CAUSE`SOAFCRDIEFAITCHE B: Y DESIGN. No MiLcIrVEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedSKE: LETAL WUSCLE, SPLEEN, ATSOLARELTUIAMV,,ARYBCREACGIULNMA.,NDSSC,OPLIONMNAA,LNDCRIOEBRCUDTL,UAMR,STLOYMMMEAPSCHEHN,TNEODRDEIU,OCDETLNHYUYWMMP,UiS,JNOEDJAEUD.NRUEMN,AL GAELVRAENN(TDSHS)Y,RWOISITCHIDATGOILPCATNIDCNSE,RNVEERT,VREA,CPHIESTAKU,IINT,AERSYOPPRHOGASLGATUNASDT,.E, TPHSHEYAMRRIYONNIAXD/LLGALVARENYSDNI.KC,LES, GSRTIERNNAURMY, BLBAODNDEERM,ARRTOEWS,TESN,OSEEPIIDI&DYIMI,IDENSO,SEFEINITUR/&KNIEVE JOINT, - TE0-`CompanySanitized. Does not contTSaCAiCnBI 9H0-2-4D7a6y8:GavSaubgcehSrtoondiyc iTnoxRiactistywithOneGeneration Reproduction Evaluations DuPon-5950 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings sagas2 TKeirlmliendalonSDaacyr:ific95e AEnxipmoaslureisGrsoiugnped: o9f0f-DafyroEmxnpeocsruroepsy Gross Pathology No Ma`LcIrVoEsR,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedS:KELETAL MUSCLE, SPLEEN, ANLOOERDTEM,A,, SAPBRALANIICVNRA,ERAYSS,PGLIACNNEACDLUSN,C,ORMDCA.ONLDOSINTB,OUMLAARCREHC,TLUYMMD,PUOHDMEENNOSUDEMEN,,TEJTREHIJYCUMNULUSYM,M,PH TADHRYERNOAILD GGLLAANNDD,S, PSACRIAATTHIYCROINDERVGEL,ANDPSI,TUTIRTAACRHYEAG,LANEDS,OPHAGUS, SBHEAMRIYNNAXL/LVAERSYINCKL,ES,EYEU(RSI)NARWYITHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. - BYE(S)HEWMIOTRRHHAOGPET/ICINNFELRAVMEMATION (BLEEDING PROCEDURE), minimal. CAUSESOAFCRIDFEIACTEH BY DESIGN. No MiSLcIPVrIEoNRsA,cLopLCOUiRNcDG,SA,bnSoHTErOAMmRAaTCl,Hi,tySKDOUEbOLDsEEeTNrAULvMe,MdUSJ:CELJEU,NUMS,PLEIELNE,UM,AORPTAAN,CREBARSA,IN, `CGBLCAUNMD,S,COMLAONND,IBURLECATRUML,YMMPEHSENONDTEE,RICTHYLMYUMSP,H ANODDREE,NALSAGLLIAVNADRSY, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 646492 Continued on the next page .... aI Company Sanitized. Does not contain TSCA CBI 9H0.-2D47a6y8G:avSaubgcehSrtoundiyc TinoxRiactistywith One.Generation Reproduction Evaluations DuPont5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 6asas2 Continued from previous page Histopathology No MiPcArRoAsTcHoYpRiOcIDAbGLnAoNrDmSa,litTyRACOHbEsAe,rveEdS:OPHAGUS, BHARYNX/LARYNK, ESKPIIND,IDYPNRIODSETSA,TE,FEMSUERM/IKNNAELEVEJSOIICNLTE,S,STEURRNIUNMA,RYBOBNLAEDDMEARR,ROWT,ESTNEOSS,E I&II, NOSE III & IV 6a6asa KTeirlmliendalonSaDcary:ific1e23 AEnxipmoaslureisGrsoiugpned: o1f-fNonftrhomRenceocvreorpysy Gross pathology No MaLcIVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TEJRIECUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, - TPHHAYRRYOVINDX/GLLAARNYDN,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA.TE, FSEEMMIUNRA/LKNVEEESIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology THYROIALDTEGRLAATNIDON:, COLLOID, minimal. CAUSESOAFCRIDFEIACTEH B Y DESIGN 646494 Continued on the next page Tez. Company Sanitized. Doasnot containTSCA CBI 9H02-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywithOne.Generation Reproduction Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 ma/ka/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646454 Continued from previous page Histopathology : No MiLIcVrEoRs,copKiIDcNEAYbSn,ormSaPlLiEtEyN Observed : 646495 KTeirlmliendalon SaDcayrif: ic1e83 . EAnxipmoaslureisGrsoiugpned: 3of-fMonftrhomRenceocvreorpysy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormSaPlLEiEtNy, OTbHsYeRrOvIeDd G:LAND, PARATHYROID GLANDS, TESTES Histopathology : LiverINFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. - KIDNE`YNSEP:HROPATHY, CHRONIC PROGRESSIVE, minimal. THYROIADLTEGRLAATNIDON:, COLLOID, minimal. CAUSE`SOAFCRDIEFAITCHE B Y DESIGN. No Mi`ScPrLoEsEcNopic Abnormality Observed : Tie Company Sanitized. Doasnot contain TSCA CBI H9-02-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywithOne-Generation Reproduction Evaluations DuPon-5990 --_ INDIVIDUAL ANDAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : ITI - 25 mg/kg/day Sex: ales Animal Ref Microscopic & Macroscopic Findings 646368 TKeirlmliendalonsaDcaryif: ic1e83 EAnxipmoaslureisGrsoiugpned: o3f-fMonftrhomRenceocvreorpysy Gross Pathology No MaLcIrVEoRs,copKiIcDNEAYbSn,ormSaPlLEiEtNy,ObTsHeYrRvOeIdD G:LAND, PARATHYROID GLANDS, TESTES Histopathology : KIDNEYNSEPH: ROPATHY, CHRONIC PROGRESSIVE, minimal. spLEENHEMATOPOIESIS, INCREASED, minimal. THYROIADLTEGRLAATNIDON, COLLOID, mild CAUSE`SOAFCRDIEFAITCHE B| Y DESIGN. -- No MiLcIrVoEsRcopic Abnormality Observed 646370 TKeirlmliendalonSaDcaryif: ic5e EAnxipmoaslureisGrsoigunped: o9f0f-DafyromExnpeocsruroepsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS.PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYWUS, 646370 Continued on the next page --.- was Company Sanitized.Doesnot contain TSCA C81 H9-02-4D7a6y8:GavSaugbeehSrtoundiycTionxRiactistywith One-Generation Reproduction Evaluations DuPont5990 - INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646370 Continued from previous page Gross Pathology No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDerGvLAeNdDS, TRACHEA, ESOPHAGUS, . SPHEAMRIYNVANLI/VLEASRIYCNXL,ES.EVEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : Laver:HYPERTROPHY, CENTRILOBULAR, minimal KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. THYROAILDTEGRLAATNIDON:, COLLOID, minimal. cauSE`SOAFCRDIEFAITCHE BY DESIGN. No MiscprLoEsEcNopic Abnormality Observed : 646399 TKeirlmliendalonSaDcayri:fic9e5 EAnxipmoaslureisGrsoiugpned: o5f0f-DafyroEmxpnoescurroepsy Gross Pathology : No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM.PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, 646399 Continued on the next page 5-`CompanySanitized. Doesnot conTtSaCAiCBnI 9H0--2D47a6y8G:avSaugbeehSrtoundiyc TinoxRiactistywithOne-Generation Reproduction Evaluations DuPont 5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : ITT - 25 mg/kg/day Sex: wales Animal Ref Microscopic & Macroscopic Findings 646399 Continued from previous page Gross pathology No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDerGvLAeNdDS:, TRACHEA, ESOPHAGUS, SPHEAMRIYNNAXL/LVAERSYINCKL,ES,EYEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIveRHY: PERTROPHY, CENTRILOBULAR, minimal. THYROIADLTEGRLAATNIDON:, COLLOID, moderate. cause`SOAFCRDIEFAITCHE BY DESIGN No MiKcIrDNoEsYcSo,picSPALbEnEoNrmality Observed - 646410 TKeirlmliendalonSaDcary:ific9e5 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsurroepsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANDODREE,NASLALGILAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND,THYMUS, 646414 Continued on the next page 856 Company Sanitized. Does not contain TSCA CBI H9-02.4D7a6y8G:avSaubgeehSrtoundiyc TinoxRiactistywithOne-Generation Reproduction Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 6asaLs Continued from previous page Gross Pathology + No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTHtYyROOIbDserGLvAeNdDS:, TRACHEA, ESOPHAGUS, SHEAMRIYNNAKL/LVAERSYINCKL,ES.EYEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE' JOINT, STERNUM, NOSE Histopathology : LIVERSATTY CHANGE, MEDIAN CLEFT, minimal. `THYRO`IADLTGELRAANTDION:, COLLOID, mild. CAUSESOAFCRDIEFAITCHE B Y DESIGN No MiKcIDrNoEsYcSo,picSPALbEnEoNrmality Observed : --_ sa6421 TKeirlmliendalonSaDcayri:fic9e5 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsruroepsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL WUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCAECLUMC,ORDC.OLOSNT.OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NASLALGLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYWUS, 646421 Continued on the next page .... Te Company Sanitized. DoesnotcontainTSCA CBI H-24768: Subchronic 90-Day Gavage Study TionxRiactistywithOne:Generation Reproduction Evaluations DuPon-5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: wales Animal Ref Microscopic & Macroscopic Findings prezent Continued from previous page Gross Pathology : No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDerGvLAeNdDS:, TRACHEA, ESOPHAGUS, . SPHEAMRIYNNAKL/LVAERSYINCKL,ES,EYEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE : Histopathology THYRO`IADLTGELRAANTDION:, COLLOID, severe. CAUSESOAFCRDIEFAITCHE BY DESIGN No MiLIcVrEoRs,copKiIcDNEAYbSn,ormSaPlLiEtEyN Observed : 646423 - KTeirlmliendalonSaDcaryif: ic9e5 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeoscurroepsy Gross pathology No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedSKELETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, 646423 Continued on the next page HoH CompanySanitzed.DossnotconTtSaCAiC8n1 H9-02-4D7a6y8:GavSaugbcehSrtourdiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPon-5990 -_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: IIT - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 6a6az3 Continued rom previous page Gross Pathology No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDerGvLAeNdDS, TRACHEA, ESOPHAGUS. PSHEAMRIYNNAXL/LVAERSYINCKL,ES,EVEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYRO`IADLTGELRAANTDION:, COLLOID, severe. CAUSEHOYFPERDTERAOTPHHY:, FOLLICULAR, minimal. `SACRIFICE BY DESIGN No MiLIcVrEoRs,copKiIcDNEAYbSn,ormSaPlLiEtEyN Observed : 646426 - KTeirlmliendalonSaDcaryif: ic9e5 EAnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsruorepsy Gross Pathology URINA`RCYALBCLUALDUDSE\RCA:LCUL.T 646426 Continued on the next page ... To `Company Sanitized. Doesnot contain TSCA C81 H902-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 ~~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: ITT - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings sa6a26 Continued from previous page Gross Pathology No MaLcIVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, IALOERUTMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TEJREIJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYWUS, TPHHYARROYINDX/LGALRANYDN,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SSTEEMRINNUAML,VENSOISCELES, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, Histopathology KxoNev`HsYD:RONEPHROSTS, BILATERAL, mild `THYRONIEDPHGRLOAPNADTH:Y, CHRONIC PROGRESSIVE, minimal URINAARLYTEBRLAATDIDOENR, :COLLOID, severe. - HIYNPFELRAPMLMAASTIIAO,N, TRSAUBNASCIUTTIEO/NCAHLROCNEILCL,, mmiinniimmaall CAUSESAOFCRIDFEIACTEH BY DESIGN No MiLIcVrEoRs,copSiPcLEAEbNnormality Observed : "860- Company Sanitized. Doesnot contain TSCA CBI 9H02-4D7a6y8:GaSvuabgeelSruondiyciTnoRxaictistwyith One-GenerationReproductionEvaluations DuPon5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day sex: wales Animal Ref Microscopic & Macroscopic Findings 646436 TKeirlmliendalonSaDcaryi:fic1e83 AEnxipmoaslureisGrsoiugpne:d o3f-fMonftrhomRneeccorvoeprsyy Gross pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormSPaLlEiEtNy, ObTsHeYrRvOeIdD G: LAND, PARATHYROID GLANDS, TESTES Histopathology THYROIALDTEGRLAATNIDON, COLLOID, mild. CAUSESOAFCRDIEFAITCHE B| Y DESIGN. No MiLcIrVEoRs,copKiIcDNEAYbSn,ormSaPlLiEtEyN Observed 646438 --_ KTeirlmliendalonSaDcary:ific1e83 AEnxipmoaslureisGrsoigunped: 3of-fNonftrhomRenceocvreorpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orSmPaLlEiEtNy, ObTsHeYrRvOeIdD GLAND, PARATHYROID GLANDS, TESTES 646438 Continued on the next page -.. Hol CompanySanitized. DossnotcontTSaCAiCnBI `H9204-7D6a8y:GavSaugbeehSrtonaiyc TinoxRiactistywith OneGeneration Reproduction Evaluations DuPont 5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: IIT - 25 mg/kg/day Sex: Males Animal Ref 6a6a3s Microscopic & Macroscopic Findings Continued from previous page Histopathology KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal THYROIALDTEGRLAATNIDON, COLLOID, moderate CAUSESOAFCRDIEFAITCHE B: Y DESIGN 7 No MiLIcVrEoRs,copSiPcLEAEbNnormality Observed 646443 TKeirlmliendalonsDaacyr:ific9e5 EAnxipmoaslureisGrsoiugpne:d o9f0f-DafyroEmxpnoescurroepsy Gross pathology KIDNEYDSILATATION, RIGHT, PELVIS -- THOUSDISCOLORATION, BILATERAL No MaLIcVrEoRs,copLiUcNGSA,bnoHrEAmRaTl,itySKOEbLEsTeArLveMdU:SCLE, SPLEEN, AORTA, BRAIN, SCEPCIUNMA,L CCOORLDO,N, STROEMCATCUHM,, DMUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODTEL,ECMS,ALIPAVNACRRYEAS, GNELRAVNED,S, PMIATNUDIITBARUYLARGLALNYDM,PHTNHOYDREO,IDADGLRAENNDA,L GPLAARNADTSH,YROSICDIATGLIACNDS, 646443 Continued on the next page .... THz `CompanySanitized. DoesnotconTtSaCAiC8n1 H902-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywith One Generation Reproduction Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : ITI - 25 mg/kg/day Sex: Males Animal Ret Microscopic & Macroscopic Findings sa6as3 Continued fron previous page Gross Pathology No MaTRcArCoHsEcAo,picESAOPbHnAoGrUmSa,litPyHAROYbNsKe/rLvAeRdYNK, . UERYEI(NSA)RYWIBTLAHDDOEPRT,ICTENSERTVEES,, ESKPIIND,IDYPMRIODSETSA,TE,FEMSUERM/IKNANLEEVEJSOIINCTL,ES, STERNUM, NOSE Histopathology LIVERHY: PERTROPHY, CENTRILOBULAR, minimal KIDNEYISNFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal THOSHYDRONEPHROSIS, UNILATERAL, mild THYROINDO GMILCARNODSC: OPIC EVIDENCE OF MACROSCOPIC FINDING. CAUSEALOTFERDAETAITOHN,| COLLOID, minimal. `SACRIFICE BY DESIGN No MiScPrLoEsEcNopic Abnormality Observed 646229 TKeirlmliendalonsaDacyr:ific1e83 AEnxipmoaslureisGrsoiugpned: o3f-fMonftrhomRneeccorvoeprysy Gross Pathology : No MaLcIrVEoRs,copKiIcDNEAYbSn,ormSaPLlEiEtNy, OTbHsYeRrOvIeDd G:LAND, PARATHYROID GLANDS, 646449 Continued onTEtShTeESnext page .. 6 CompanySanitized.Doesnot conTtSaCAiCBnI H902-4D7a6y8:GaSvuabgcehrSotruidcyiTnoRxaictistywith One Generation Reproduction Evaluations DuPont-5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IIT - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 6a6415 Continued from previous page Histopathology : LIveRFATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. `THYROAIUDTEGRLAATNIDON:, COLLOID, moderate. : CAUSE`SOAFCRDIEFAITCHE B| Y DESIGN No MiScPrLoEsEcNopic Abnormality Observed : sa6as3 TKeirlmliendalonsDaacyrif: ic1e83 EAnxipnoasluraisGrsoiugpned: o3f-fMonftrhomRneeccorvoeprysy Gross Pathology _ No MaLIcVrEoRs,copKiIDcNEAYbSn,ormSaPLlEiEtNy, ObTsHeYrRvOeIdD G: LAND, PARATHYROID GLANDS, TESTES Histopathology LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, mild. THYRO"IADLTGELRAANTDION:, COLLOID, moderate. 646453 Continued on the next page -.. pre CompanySanitized. Doesnot conTtSaCAiCBnI H-24768: Subchronic 96.Day Gavage Study TinoxRiactistywithOneGeneration Reproduction Evaluations DuPont 5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IIT - 25 ma/ka/day sex: vales Animal Ref Microscopic & Macroscopic Findings 646453 Continued from previous page Histopathology CavSE`OSAFCRDIEFAITCHE BY DESIGN. No Mi`ScPrLoEsEcNopic Abnormality Observed : Ga64se TKeirlmliendalonSaDcayrif: ic9e5 AEnxipmoaslureisGrsoiugpne:d 0of-fDafyromExnpeocsruorepsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL WUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT.OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRY NOGDLEA,ND,THYMUS, PP TPHHYARRYONIAD/LGALRAYNND,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRAVEC,HEAS,KINE,SOPPHRAOGSUTSA.TE, SFEEMMTUNRA/LKNVEEESIJCOLIENST,, SUTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, Histopathology THYROIADLTEGRLAATNIDON, COLLOTD, minimal CAUSESAOFCRIDFEIACTEH BY DESIGN 646454 Continued on the next page .... 86s Company Sanitized. Dossnotcontain TSCA CBI 9H02.4D7a6y8:GavSaubgeehSrtoundiyc TinoxRiactistywith One Generation Reproduction Evaluations DuPon-5990 -- INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: III - 25 mg/kg/day Sex: males Animal Ref Microscopic & Macroscopic Findings sa6ase Continued from previous page Histopathology No Mi`LcIrVoEsR,copKiIDcNEAYbSn,ormSaPlLiEtEyN Observed . easass KTeirlmliendalonSaDacyri:fic9e5 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross pathology No MaAEOcCRrVTEoARs,,copEBiRIcADINNEA,YbSn,oSrPmLIaUNNlAGiLSt,yCOROHDbE,AsReTrS,vTeOdMSAKCE:HL,ETADLUODMEUNSUCML.E, JESJPULNEUEMN,. TNAOODDEREUE,MN,ALSPAAGLNLICAVRNAEDRASYS,,GLSACCNEIDCASUT,NI,CMACNOENLRDOVINEB,,ULARPREICTTULUYIMMT,PAHRMYENOSGDELENA,NTDE,RTIHYCMULSY,MPH TTSHHEYAMRRIOYNIMARDL/LGVALEARSNYIDNC,KLE,SP,AEYREUA(RTSIH)NYARWROIYITDHBGLLAOADPNDTDEISRC,, NTETRREVASECT,HEES,AS,KIENEP,SIODPIPHDRAYOGMSUITSDA,ETSE,, --- 'SEMUR/KNEE JOINT, STERNUM, NOSE Histopathology aves`FHAYTPTEYRTCRHOAPNHGY,E, CEMNETDRIIALNOBCULLEAFRT,, mmiinniimmaall.. THYROIADLTEGRLAATNIDON, COLLOID, severe CAUSESOAFCRIDFEIACTEH B Y DESIGN. 646458 Continued on the next page ... - TH66`CompanySanitized.Doesnot conTtSaCAiCBnI H24768: Subchvonic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPon-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: III - 25 mg/kg/day sex: wales Animal Ref Microscopic & Macroscopic Findings 6a6ass Continued from previous page Histopathology + No MiKcIrDNoEsYcSo,picSPALbEnENormality Observed 6a6a71 TKeirlmliendalonsDaacyri:fic9e5 , AEnxipmoaslureisGrsoiugpne:d o9f0f-DafyromExnpeoscurroepsy Gross Pathology No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM., PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND.THYMUS, TPHHYARROVINXD/LGALRAYNND,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA.TE, PS SFEEMMIUNRA/LKNVEEESIJCOLIENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, Histopathology : LaverHYPERTROPHY, CENTRILOBULAR, minimal seLEEHNEM: ATOROTESTS, INCREASED, minimal. THYROAILDTEGRLAATNIDON, COLLOID, mild. CAUSESOAFCRDIEFAITCHE BY DESIGN 646471 Continued on the next page --. S67 CompanySanitzed.DossnotcontTSaCAiCanl H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646471 Continued from previous page Histopathology No MiKcIrDoNsEcYoSpic Abnormality Observed : S68- -- CompanySanitized. Does not conTtSaCAiCBnI H9-02-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywithOne:Generation Reproduction Evaluations DuPoni-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646327 KTeirlmliendalonSaDcary:ific1e83 EAnxipmoaslureisGrsoiugpned: o3f-fMonftrhomReneccorvoeprsyy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormSPaLlEiEtNy, ObTsHeYrRvOeIdD G: LAND, PARATHYROID GLANDS. TesTES Histopathology LIVERFA: TTY CHANGE, MEDIAN CLEFT, minimal THYROIADLTEGRLAATNIDON:, COLLOID, minimal. CAUSE`SOAFCRDIEFAITCHE BY DESIGN No MiKIcDrNoEsYcSo,picSPALbEnEoNrmality Observed -- 646335 KTeirlmliendalonSDaacyr:ific1e83 EAnxipmoaslureisGrsoiugnpe:d o3f-fYonftrhomRneeccorvoeprysy Gross Pathology No MaLcIVrEoRs,copKiIDcNEAYbSn,ormSaPlLEiEtNy, OTbHsYeRrOvIeDd G:LAND, PARATHYROID GLANDS, TESTES 646335 Continued on the next page -... - we______________ Company Sanitized. Does not containTSCACBI H9-02-4D7a6y8G:avSaubgeehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPon-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: V - 100 mg/kg/day sex: wales Animal Ref Microscopic & Macroscopic Findings 646335 Continued from previous page Histopathology : LIVERFA: TTY CHANGE, MEDIAN CLEFT, minimal KIDNEYISNFL: AMMATION, SUBA| CUTE/CHRONIC, FOCAL, minimal SPLEENNEP:HROPATHY, CHRONIC PROGRESSIVE, minimal. THYROIHDEMAGTLOAPNODTE+STS, INCREASED, minimal CAUSEALOTFERDAETAITOHN, COLLOTD, minimal. SACRIFICE BY DESIGN. 646345 TKeirlmliendaolnsaDcaryif: ic95e AEnxipmoaslureisGrsoiugpned: 90-Day Exposure off from necropsy Gross Pathology : --- No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,IC MANENRDVIEB,ULAPRITULIYTMAPHRY NOGDLEA,ND.THYMUS, TPHHYARROYINKD/LGALRAYNND,K, `PBAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNVEEESIJCOLIENST,, USRTIERNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, 646349 Continued on the next page -... Te `Company Sanitized. DoesnotcontainTSCA CBI 9H0.2-4D7a6y8:GaSvuabgeehrSotnuidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: V - 100 mg/kg/day sex: Males Animal Ref Microscopic & Macroscopic Findings 64639 Continued from previous page Histopathology + LIVERHY: PERTROPHY, CENTRILOBULAR, minimal . KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEHNEM:ATOPOTESIS, INCREASED, minimal. THYROAILDTEGRLAATNIDON:, COLLOID. minimal CAUSEHYOPFERDTERAOTPHHY:, FOLLICULAR, minimal `SACRIFICE BY DESIGN 646373 TKeirlmliendalonSaDcaryif: ic95e EAnxipmoaslureisGrsoigunped: o9f0f-DafyroEmxpnoescurroepsy Gross Pathology - LiverLARGE. wioLESIBTOUDSY:INVERSUS. No MaKIcDrNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y SOKbEsLeErTvAeLd M: USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PINCEACLUNC,ORDC.OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PHILNEOUDME,, GSLAALNIDVSA,RYSCGILAANTDISC,NEMRAVNED,IBUPLIATRUITLAYRMYPHGLNAONDDE,, TTHHYYMRUOST,D AGDLARNEDN,AL 646373 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI H.24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproduction Evaluations DuPont5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 m/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646373 Continued from previous page Gross Pathology No MaPcArRoAsTcHoYpRiOcIDAbGLnAoNrDmSa,liTtRyACOHbEsAe,rveEdSOP:HAGUS, PHARYNX/LARYNX, EUYREI(NSA)RYWIBLTAHDDOEPRT,ICTENSETREVSE,, ESKPITND,IDYPMRIODSETSA,TE,FENSUERN/IKNNAELEVEJSOIINCTL,ES, STERNUM, NOSE Histopathology : LaverHYPERTROPHY, CENTRILOBULAR, mild. KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, spreeHEMATOPOIESIS, INCREASED, minimal THYROAILDTEGRLAATNIDON:, COLLOID, mild. CAUSEHYOPFERDTERAOTPHHY, FOLLICULAR, minimal. `SACRIFICE BY DESIGN. minimal 646376 TKeirlmliendalonSDaacyri:fic1e83 AEnxipmoaslureisGrsoiugpned: o3f-fMonftrhomRenceocvreorpysy Gross Pathology + No MaLIcVrEoRs,copKiIDcNEAYbSn,ormSPaLlEiEtNy, OTbHsYeRrOvIeDd G: LAND, PARATHYROID GLANDS, 646376 Continued on`TtEhSeTEnSext page .... Ton Company Sanitized. Donotecontsain -- TSCA Cal 9H02-4D7a6y8:GavSaugbeehSrtoundiyc iTnoxRiactistywithOne-Generation Reproduction Evaluations DuPon-5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: wales Animal Rot Microscopic & Macroscopic Findings 646376 Continued from previous page Histopathology : KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. THYROAILDTEGRLAATNIDON:, COLLOID, mild. CAUSESAOFCRIDFEIACTEH BY DESIGN No MiLIcVrEoRs,copSiPcLEAEbNnormality Observed : 646385 KTeirlmliendalonSDaacyr:ific95e AEnxipmoaslureisGrsoiugpned: oSf0f-DafyromExnpeocsruorpesy Gross Pathology --- No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt.y HOEbAsReTr,vedSKE: LETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JESJPULNEUEMN,, NIOLDEEU,M,'SAPLAINCVRAERAYS,GLACNEDCSU,M, MCAONLDOINB,ULARRECTLUYMM,PHMNEOSDEEN,TERTIHCYMULSY,MPH ATDHRYERNOATLD GGLLAANNDD,S, PSACRIAATTHIYCROINDERVGEL,ANDPSI,TUTIRTAACRHYEAG,LANEDS,OPHAGUS, PSHEAMRIYNNAXL/LVAERSYINCKLE,S,EYEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE 646385 Continued on the next page we `Company Sanitized. Doesnotcontain TSCA -- CBI 1H9-02-47D6y8G:avSaubgeehSrtoundiyc iTnoxRiactistywithOneGeneration Reproduction Ealuations DuPoni:5990 -~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646385 Continued from previous page Histopathology LiverHYPERTROPHY, CENTRILOBULAR, mild . THYROIIDNFLGALIADNADTION, SUBACUTE/CHRONIC, FOCAL, minimal. ALTERATION, COLLOID, severe. : CauSEHOYFPERDTERAOTPHHY, FOLLICULAR, minimal `SACRIFICE BY DESIGN. No MiKcIDrNoEsYcSo,picSPALbEnENormality Observed : 646403 TKeirlmliendalonSaDcary:ific1e83 AEnxipmoaslureisGrsoiugpne:d o3f-fMonftrhomRenceocvreorpysy Gross Pathology _ No MaLcIrVEoRs,copKiIcDNEAYbSn,orSmPaLlEiEtNy, ObTsHeYrRvOeIdD GLAND, PARMTHYROID GLANDS, TESTES Histopathology : KIoNEYNSEPH: ROPATHY, CHRONIC PROGRESSIVE, minimal THYROIADLTEGRLAATNIDON:, COLLOID, minimal. CAUSESOAFCRIDFEIACTEH BY DESIGN. 646403 Continued on the next page .. 7a CompanySanitized.Does not conTtSaCAiCBnI H9-02-4D7a6y8:GaSvuabgcehrSotruidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPont5990 PP INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646403 Continued from previous page Histopathology : No MiLIcVrEoRs,copSiPcLEAEbNnormality Observed : 646435 KTeirlmliendalonSaDcary:ific9e5 EAnxipmoaslureisGrsoiugpned: o$f0f-DafyroEmxpnoescurroepsy Gross Pathology + No MaLcIVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODWEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULAPRITULYIMTPAHRYNGODLEA,ND,THYWUS, TPHHYARRYONIXD/LGALRAYNND,K, PAEVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, - SFEEMMIUNRA/LKNVEEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology LIVERHYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. seLEENHYDRONEPHROSIS, UNILATERAL, minimal PHEIMGAMTEONPTOIIENSCIRSE,ASEIDN,CREmAiSnEiDm,al.minimal. 546435 Continued on the next page ... Tse Company Sanitized. Doesnotcontain TSCA CBI F-24768: Subchvoric Toxicity . 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646435 Continued from previous page Histopathology THYROIADLTEGRLAATNIDON, COLLOID, severe. CAUSEHYOPFERDTERAOTPHHY, FOLLICULAR, minimal. : `SACRIFICE BY DESIGN. sa6ass TKeirlmliendalonsDaacyr:ific95e AEnxipmoaslureisGrsoiugpned: o$f0f-DafyroEmxpnoescurroepsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC.OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH - NAODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND.THYMUS. THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, SPEHMAIRNYANLX/LVAERSYINCXL,ES,EYEU(RSI)NAWRIYTHBLOADPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER:HYPERTROPHY, CENTRILOBULAR. minimal SPLEENHEMATOPOIESIS, INCREASED, minimal. 646455 Continued onPIthGeHENnTextINpCRaEgAeSE.D.,.. minimal. we Company Sanitized. Does not contain TSCA CBI 9H0L2-4D7a6y8:GaSvuabgcehrSotnuidcy iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646455 Continued from previous page Histopathology : THYROAILDTEGRLAATNIDON:, COLLOID, severe. CAUSEHYOPFERDTERAOTPHHY:, FOLLICULAR, minimal. `SACRIFICE BY DESIGN. : No miKcIrDoNsEcYoSpic Abnormality Observed : 6asase KTeirlmliendalonSaDcary:ific9e5 EAnxipmoaslureisGrsoigunped: o$f0f-DafyroEmxpnoescurroepsy Gross Pathology : No MaLcIVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, -- RTOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NAL"SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPHRYNGODLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNNDK,, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNVEEESIJCOLIENST,, SUTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, Histopathology : LiverHYPERTROPHY, CENTRILOBULAR, minimal. 646456 Continued on the next page .... _--_-- Company Sanitized.Doesnotcontain TSCA CBI H9L02-4D7a6y8G:avSaubgeehSrtoundiyc iTnoxRiactistywith One-Generaton Reproduction Evaluations DuPon-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: V - 100 mg/kg/day sex: wales Animal Ref Microscopic & Macroscopic Findings 5464s Continued from previous page Histopathology LaverFATTY CHANGE, MEDIAN CLEFT, minimal spLeEHNEM:ATOPOJESTS, INCREASED, minimal THYROIPDIGGHLENATNDIN: CREASED, minimal. CAUSEALOTFERDAETAITOHN, COLLOID, mild. `SACRIFICE BY DESIGN. No MiKcIDrNoEsYcSopic Abnormality Observed : 646463 KTeirlmliendalonSaDcary:ific95e AEnxipmoaslureisGrsoigunpe:d o9f0f-DafyromExnpeocsruroepsy Gross Pathology KIDNEYDSILATATION, RIGHT, PELVIS. No MaLcIrVEoRs,copLiUcNGSA,bnoHErAmRaTl,itySKOEbLsEeTrALveMdUS:CLE, SPLEEN, AORTA, BRAIN, CSEPCIUNMA,L CCOOLRODN,, STROEMCATCUHM,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODTEL,EUMS,ALIPVAANCRRYEAS, GSLCAINADTSI,C MNEARNVDEI,BULPAIRTUILTYAMRPYH GNOLDAEN,D, THTYHMYURSO,IDADGLRAENNDA,L GLANDS, 646463 Continued on the next page ... EreCompanySanitized.Does notconTtSaCAiC8n1 9H0-2-4D7a6y8:GaSvuabgeehrSotnuidcy TinoxRiacsitywithOne.Generation Reproduction Evaluations DuPont. 5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646463 Continued from previous page Gross pathology No maPcArRoAsTcHoYpRiOcIDAbGLnAoNrDmSa,liTtRyACOHbEsAe,rveEdSOPHAGUS, PHARYNX/LARYNX, . UERYEI(NSA)RYWIBTLHADDOEPRT,ICTENSETREVSE,, ESKPIIND,IDYPMRIODSETSA.TE,FESNEUMR/IKNNAELEVJEOSIINCTL,ES, STERNUM, NOSE . Histopathology + LaverHYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal SPLEENNO: MICROSCOPIC EVIDENCE OF MACROSCOPIC FINDING. HPEIMGAUTEONPTOIIENSCIRSE,ASEIDN,CRmEAiSnEiDn,al minimal. THYROIADLTEGRLAATNIDON:, COLLOID. moderate - CAUSEHYOPFERDTERAOTPHHY, FOLLICULAR, minimal `SACRIFICE BY DESIGN -= `CompanySanitized.Doesnot conTtSaCAiCBnI H9-02-4D7a6y8:GavSaugbcehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646469 KTeirlmliendalon SDaacyrif: ic9e5 AEnxipmoaslureisGrsoiugpne:d o9f0f-DafyromExnpeocsruorepsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM!, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANDODREE,NASLALGTLAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, PTHHAYRRYONIXD/LGALRAYNND,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEEESIJCOLIENST,, USTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, Histopathology : LIVERHY: PERTROPHY, CENTRTLOBULAR, minimal. - THYRO`IADLTGELRAANTDION:, COLLOID, moderate. CAUSEHOYFPERDTERAOTPHHY:, FOLLICULAR, minimal. SACRIFICE BY DESIGN No MiKIcDrNoEsYcSo,picSPLAEbEnNormality Observed wm CompanySanitized.DoesnotconTtSaCAiC8n1 H902-4D7a6y8:GaSvuabgcehrSotruidcy iTnoxRiactistywith One-Generation Reproduction Evaluations DuPon-5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings sa6a72 TKeirlmliendalonSaDcaryif: ic9e5 AEnxipmoaslureisGrsoiugnped: o9f0f-DafyromExnpeocsruorpesy Gross Pathology . No MaLAIOcVRrEToRAs,,copKBiRIcADINNEA,YbSn,oSrPmILaNUNAlGLiSt,CyORHODEb,AsReTrS,TvOeMSdAKCE:HL,ETDAULODMEUNSUCML,E, JESJPULNEUEMN,, NILOEDUEM,, SAPALNICVRAERAYS,GLACNEDCSU,M, MACONLDOINB,ULARRECTLUYMM,PHMNEOSDEEN,TERTIHYCMULSY,MPH ATDHRYERNOAILD GGLLAANNDD,S, PSACRIAATTHIYCRONIEDRVGEL,ANDPSI,TUTIRTAACRHYEAG,LANEDS,OPHAGUS, PSHEAMRIYNNAKL/LVAERSYINCXL,ES,EVEU(RSI)NARWYITHBLAODPDTEIRC, NTEERVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVERHY: PERTROPHY, CENTRILOBULAR, minimal -_ KIDNEYPSYELONEPHRITIS, BILATERAL, minimal SPLEENHEMATOPOTESTS, INCREASED, minimal. `THYRO`IADLTGELRAANTDION:, COLLOID, severe. CAUSEHOYFPERDTERAOTPHHY:, FOLLICULAR, minimal. SACRIFICE BY DESIGN -- =, Company Sanitized. Does not contain TSCA CBI H-24768: SubchronicToxicity 90-Day Gavage Study in Rats with Ore-Generation Reproduction Evaluations DuPon-5990 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: V - 100 mg/kg/day Sex: wales Animal Ref Microscopic & Macroscopic Findings 646477 FDuoruantdioDneadof dosing-days: 51 EAnxipmoaslureisGrsoiugpned: o9f0f-DafyroEmxpnoescurroepsy Gross pathology EYE(S)HEWMOIRTRHHAOGPET,ICRINGEHRTV,E s: evere. . No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNGODLEA,ND.THYMUS, TPHHYARRYONIXD/LGALRAYNND,K, PASKRIANT,HYRPROOTSDTAGTLEA,NDSS,EMTIRNAACLHEVAE,SICELSEOSP.HAGUURSI,NARY NBoLsADzDER, TESTES, EPIDIDYMIDES, FENUR/KNEE JOINT, STERNUM, Histopathology + ~ KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal SPLEEHNEM:ATOPOTESTS, INCREASED, minimal. IegoNAMUTO:LYSTS: NECROPSY AND HISTOLOGY PERFORMED. LEUAUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED THYROIADUTOGLLYASNTDS: NECROPSY AND HISTOLOGY PERFORMED. EYE(S)HEWMIOTRRHMAOGPET/ICINNFELRAVMEMAT:ION (BLEEDING PROCEDURE), severe 646477 Continued on the next page .... - =_ CompanySanitized.Does notconTtSaCAiC8nl F-24768: Subchroric Toxicity 90-Day Gavage Study in Rat withOne-Generation Reproduction Evaluations DuPon5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: V - 100 mg/kg/day sex: wales Animal Ref Microscopic & Macroscopic Findings 646477 Continued from previous page Histopathology : PROSTAITNEFLAMMATION, SUBACUTE/CHRONIC, minimal. CAUSEEYOEF: DEHAETMHORRHAGE/INFLAYMATION (BLEEDING PROCEDURE). No MiLIcVrEoRs,copLiUcNGSA,bnoHrEAmRaTl,itySKEOLbEsTeArLveMdUS:CLE, AORTA, BRAIN, SPINAL CCOORLDO,N, "SRTEOCMTAUCMH,, MDUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANCRRYEAGSL,ANDCSE,CUM, NMEARNVDEI,BULPAIRTUILTYAMRPYH GNLOADNE,D,THTYHMYURSO,IDADGLRAENNDA.L GPLAARNADTSH,YROSICDIATGLIACNDS. UTRRAICNHAERAY, BLEASDODPEHRA,GUST,ESTPEHSA,RYNEKP/ILDAIRDYYNMXI,DESS,KINF,ENSUERN/IKNNAELE JVOEISNITC,LES, STERNUM, BONE MARROW, NOSE I & II, NOSE ITI & IV 646488 KTeirlmliendalonSaDcary:ific5e BEnxipmoaslureisGrsoiugpned: 90-Day Exposure off from necropsy Gross pathology KIDNEYDSILATATION, RIGHT. No MaLIcVrEoRs,copLiUcNGSA,bnoHrEAmRaTl,itySKOEbLsEeTArLveWdUSCLE, SPLEEN, AORTA, BRAIN, CSEPCIUNMA,L CCOORLDO,N, STROEMCATCUHM,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODTEL,EUMS,ALIPVAANCRRYEAS, SGLCAINADTSI,C NMEARNVDEI,BULPAIRTULIYTMAPRHY GNOLDAEN,D, THTYHMYURSO,IDAGDLRAENNDA,L GLANDS, 646488 Continued on the next page .... Toms CompanySanitized. DossnotconTtSaCAiCBnI H9-02-4D7a6y8:GavSaugbcehSrtonuidcy TinoxRiactistywith Ore-Generation Reproduction Evaluations DuPont-5990 P INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings sasass Continued rom previous page Gross pathology : No MaPcArRoAsTcHoYpRiOcIDAbGLnAoNrDmSa,litTyRACOHbEsAe,rveEdSOP:HAGUS, PHARYNX/LARYNX, . UERYEI(NSA)RYWIBTLAHDDOEPRT,ICTENSETREVSE,, ESKPIIND,IDYPMRIODSETSA,TE,FEMSUERM/IKNANLEEVEJSOIINCTL.ES. STERNUM, NOSE . Histopathology : LIverHYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYHSYDRONEPHROSTS, UNILATERAL, mild. THYRO`IADLTGELRAANTDION, COLLOID, mild. CauSEHOYFPERDTERAOTPHHY:, FOLLICULAR, minimal. SACRIFICE BY DESIGN. --- No miScPrLoEsEcNopic Abnormality Observed -- wm Company Sanitized. Does not containTSCA CBI 9H02-4D7a6y8:GavSaubgeehSrtoundiyc iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont:5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIT - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646337 KTeirlmliendalon SaDcaryif: ic1e23 EAnxiproaslureisGrsoiugpne:d o1f-fMonftrhomRneeccorvoeprsyy Gross pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNGODLEA,ND.THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC.HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMIUNRA/LKNVEEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology LIVERHY: PERTROPHY, CENTRILOBULAR, minimal. - KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. spLERNHEMATOPOTESTS, INCREASED, minimal THYROIADLTEGRLAATNIDON:, COLLOID, minimal CAUSESOAFCRDIEFAITCHE BY DESIGN. -- ww `CompanySanitized. Doesnot conTtSaCAiC8n1 H-24768: Subchronie Toxicity 90-Day Gavage Study in Rats with One- Generation Reproduction Evaluations DuPont5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings sa6303 TKeirlmliendalonSDaacyri:fic9e5 AEnxipmoaslureisGrsoiugpne:d o0f-fDafyromExnpeocsruroepsy Gross pathology : LIVERLARGE. No MaKIcDrNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y SObKsEeLrEvTeAdL M:USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH INLOEDUEM,, GSLAALNIDVSA,RYSCGILAATNIDCS NEMRAVNED,IBUPLIATRUITLAYRMYPHGLNAONDDE,, TTHHYYMRUOSI,D GALDARNEDN,AL EPYAER(AST)HYWRIOTIHD OGLPATNIDCS,NERTVREA,CHESAK,IN,ESOPPRHOASGTUAST,E, PSHEAMRIYNNAX/LLAVREYSNIKC,LES, SUTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, Histopathology + -_ LIVERHYPERTROPHY, CENTRILOBULAR, mild. seLEENPIGMENT INCREASED, minimal. THYROIHDENAGTLOAPNODTE:STS, INCREASED, minimal. AHLYTPEERRATTRIOOPNH,Y, COFLOLLOLIIDC,ULAmRo,dermaitled CAUSESOAFCRDIEFAITCHE BY DESIGN 646343 Continued on the next page .... "ase -- CompanySanitized.Doesnot conTtSaCAiCnBI 9H02-4D7a6y8:GavSaubgcehSrtoundiyc iTnoxRiactistywithOne.Generation Reproduction Evaluations DuPont.5990 - INDIVIDUAL ANINAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 616343 Continued trom previous page Histopathology : No MiKIcDrNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y OSbKsEeLrEvTeAdL M: USCLE, AORTA, BRAIN, CSEPCIUNMA,L CCOORLDO,N, SRTEOCMTAUCMH,, DMUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVANACRRYEAS, SGLCAINADTSI,C NMEARNVDEI,BULPAIRTUILTYAMRPYH GNOLDAEN,D, THPYAMRUAST,HYARODIRDENGALLANGDLSA,NDS, TERYAE(CSH)EA,WITEHSOPOHPATGIUCS,NERPVHEA,RYNSXKI/NL.ARIPNRKO,STATE, SEMINAL VESICLES, SUTREIRNNAURMY, BLBAODNDEERM,ARRTOEWS,TESN,OSEEPIIDI&DYIMTI,DENSO,SEFEITMTUR&/KNIEVE JOINT, 646344 TKeirlmliendalonSaDcaryi:fic1e83 AEnxipmoaslureisGrsoiugpned: o3f-fMonftrhomRneeccorvoeprsyy Gross Pathology --- No MaLcIrVEoRs,copKiIcDNEAYbSn,ormSaPlLEiEtNy, OTbHsYeRrOvIeDd GLAND, PARATHYROID GLANDS, TESTES Histopathology verFATTY CHANGE, MEDIAN CLEFT, minimal THYRO`IADLTGELRAANTDION:, COLLOID, mild. CAUSEHYOPFERDTERAOTPHHY:, FOLLICULAR, minimal. 646344 Continued onSAthCeRIFneIxCtE pBaYgeDES.I.GN. aT `CompanySanitized. DoesnotconTtSaCAiC8n1 H9L02-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 -- INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIT - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings prem Continued from previous page Histopathology + No MiKIcDrNoEsYcSo,picSPLAEbEnNormality Observed : 646346 KiTlerlmeidnoaln SaDcaryif: ic9e5 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsruroepsy Gross Pathology LIVERLA: RGE. sowaUcLHCER/EROSTON, GLANDULAR, FEW No MaKIcDrNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y SOKbEsLeErTvAeLd M: USCLE, SPLEEN, AORTA, CBERCAUIMN,, CSOPLIONNA,L CROERCDT,UM,DUOMDEESNEUNMT,ERIJCEJULNYUMMP,H NIOLDEEU,M, SAPLAINCVRAERAYS, - GSLCAINADTSI,C NMEARNVDEI,BULPAIRTUILTYAMRPYH GNLOADNE,D, THTYHMYURSO,IDADGLRAENNDA,L GLANDS. EPYAER(AST)HYWRIOTIHD GOLPATNIDCS,NERTVREA,CHESAK,IN,ESOPPRHOASGTUAST,E, PSHEANRYIHNXA/LLAVREYSNIKC,LES, SUTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, FENUR/KNEE JOINT, Histopathology LiverHYPERTROPHY, CENTRILOBULAR, mild. 646346 Continued on the next page - CompanySanitized.Doesnot conTtSaCAiC8n1 H-24768: Subchronic Toxicity 90-Day GavageStudyin Rats with One-Generation Reproduction Evaluations DuPon-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646345 Continued rom previous page Histopathology KIDNENYESPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEENHE:MATOPOIESIS, INCREASED, minimal. MANDI`BCUOLNAGRESLTYIOMNP,H mNiOnDiEma:l. THYRO`IADLTGELRAANTDION:, COLLOID, severe. EYE(S)HYWPEIRTTHROOPPHTYI,C FNOELRLVIECULAR, mild. CAUSHEEMOFORDREHAATGHE/: INFLAMMATION (BLEEDING PROCEDURE). SACRIFICE BY DESIGN. No MiLUcNrGoSs,copHEiAcRTA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edAO:RTA, BRAIN, SPINAL CORD, RSETCOTMUAMC,H, 'WDEUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAANRCYREGALSA,NDSC,ECUTMH.YMUCSO,LON, - GALDARNEDNSA,L TGLRAANCDHSE,A, SCBISONPTHIACGUNSE,RVEP,HARPYINTXU/ILTAARRYYNXG,LANSDK,IN,PAPRRAOTSHTYARTOEI,D FSEEMMUIRN/AKLNEVEESIJCOLIENST,, USTREIRNNAURMY, BLBAODNDEERM,ARRTOEWS,TESN,OSEEPIIDI&DYIMI,IDENSO.SE or ew we CompanySanitized.Doesnot conTtSaCAiC8n1 H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with OneGeneration Reproduction Evaluations DuPon-5990 Ps INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: VII - 500 mg/kg/day Sex: wales Animal Ref Microscopic & Macroscopic Findings 6a8347 KTeirlmliendalonSDaacyr:ific95e EAnxipmoaslureisGrsoiugpne:d o9f0f-DafyroEmxpnoescurroepsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NA'LSALGILAVNADRSY, GLSACNIDAST,IC MANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIYD/LGLAARNYDN,K, PAEVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMUIRN/AKLNVEEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology LIVER:HYPERTROPHY, CENTRILOBULAR, mild. - KIDNEYNSEP:HROPATHY, CHRONIC PROGRESSIVE, minimal. spLEENHEMATOPOTESIS, INCREASED, minimal. THYROAILDTEGRLAATNIDON:, COLLOID, severe. CAUSEHYOPFERDTERAOTPHHY:, FOLLICULAR, mild. `SACRIFICE BY DESIGN. 646347 Continued on the next page .... 0. Company Sanitized. Doesnotcontain TSCA CBI H9.02-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywithOne:Generation Reproduction Evaluations Dupon-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646347 Continued from previous page Histopathology : No MiLOcNrGoSs,copHiEcARTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edAO:RTA, BRAIN, SPINAL CORD, RSETCOTMUAMC,H, MEDUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAARNYCREGALSA,NDSC,ECUMMA,NDICOBLUOLNA,R LPYINTPUHITANORDYE,GLATNHDY,MUSP,ARAADTRHEYNRAOLIDGLGALNADNSD,S, STCRIAACTHIECA,NEREVSEO.PHAGUS, SPHEAMRIYNNAXL/LVAERSYINCXL,ES.BYEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FmEMaUR/wKNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE 646355 TKeirlmliendalonSaDcaryif: ic1e83 EAnxipmoaslureisGrsoiugpned: o3f-fNonftrhomRenceocvreorpysy Gross Pathology : _ No MaLIcVrEoRs,copKiIDcNEAYbSn,ormSPaLlEiEtNy, ObTsHeYrRvOeIdD GLAND, PARATHYROID GLANDS, TESTES Histopathology : KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal THYROAILDTEGRLAATNIDON:, COLLOID, severe. CAUSEHYOPFERDTERAOTPHHY, FOLLICULAR, minimal. 646355 Continued onSAtCheRIFneIxCtE pBaYgeDES-I.G..N -___.__________________ `Company Sanitized.DoesnotconTtSaCAiC8n1 9H0.2-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywithOne.Generation Reproduction Evalutions DuPont 5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 ma/kg/day Sex: males Animal Ref Microscopic & Macroscopic Findings 546355 Continued from previous page Histopathology No MiLcIVrEoRs,copSiPcLEAEbNnormality Observed : . eesel TKeirlmliendalonSaDcayr:ific1e83 . EAnxipmoaslureisGrsoiugnped: o3f-fNonftrhomRneeccorvoeprysy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormSaPlLEiEtNy, OTbHsYeRrOvIeDd G: LAND, PARATHYROID GLANDS, TesTES Histopathology LIVERFATTY CHANGE, CENTRILOBULAR, minimal -_ THYROAILDTEGRLAATNIDON:, COLLOID, moderate CAUSEHYOPFERDTERAOTPHHY:, FOLLICULAR, minimal `SACRIFICE BY DESIGN No MiKIcDrNoEsYcSo,picSPLAEbEnNormality Observed : ee CompanySanitized. Doesnot conTtSaCAiC8n1 9H0L2-4D7a6y8;GavSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPon-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Dose Group : VII - 500 mg/kg/day sex: Wales Animal Ref Microscopic & Macroscopic Findings 46364 TKeirlmliendalonSaDcaryi:fic1e23 AEnxipmoaslureisGrsoiugpned: oLf-fMonftrhomRneeccorvoeprysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,v'edSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRVONIXD/LGALRAYNND,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEEESIJCOLIENST,, USRTIERNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology + LIVERHYPERTROPHY, CENTRILOBULAR, minimal - SPLEEHNEMATOPOIESIS, INCREASED, minimal. PIGUENT INCREASED, minimal. THYROIALDTEGRLAATNIDON:, COLLOID, minimal CAUSEHYOPFERDTERAOTPHHY:, FOLLICULAR, minimal. `SACRIFICE BY DESIGN. No MiKcIrDoNsEcYoSpic Abnormality Observed Tos. Company Sanitized. Does not contain TSCA CBI 9H02-4D7a6y8:GaSvuabgeehrSotnudiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont 5990 --_ INDIVIDUAL ANTMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: VIT - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 546369 TKeirlmliendalonsaDacyr:ific1e23 AEnxipmoaslureisGrsoiugpned: o1f-fMonftrhomRenceocvreorpysy Gross Pathology N*o Ma"LcIrVoEsR,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PINCAECLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NA`LSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNND,X, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMUIRN/AKLNEVEESIJCOLIENST,, SUTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, Histopathology + KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. --_ THYROIALDTEGRLAATNIDON:, COLLOID, moderate. CAUSEHOYFPERDTERAOTPHHY:, FOLLICULAR, minimal. SACRIFICE BY DESIGN. No MiLcIVrEoRs,copSiPcLEEANbnormality Observed Te Company Sanitized. Does not contain TSCA CBI H902-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywith One.Generation Reproduction Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646372 TKeirlmliendalonsaDcary:ific1e23 AEnxipmoaslureisGrsoiugnped: o1f-fNonftrhomRenceocvreorpysy Gross pathology No MaLcIVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT.OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONTKD/LGALARNYDN,X, PEAVREA(TSH)YROWIIDTHGOLPANTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA.TE, SFEEMMUIRN/AKLNVEEESIJCOLIENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, Histopathology : LIverHYPERTROPHY, CENTRILOBULAR, minimal. - KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROIADLTEGRLAATNIDON:, COLLOID. severe CAUSEHYOPFERDTERAOTPHHY:, FOLLICULAR, minimal `SACRIFICE BY DESIGN. No MiScPrLoEsEcNopic Abnormality Observed : -____ __ CompanySanitized. Dossnotcontain TSCA CBI 9H0.2-4D7a6y8:GavSaubgeehSrtoundiyc TinoxRiactistywith OneGeneration Reproduction Evaluations DuPon5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646380 DFuoruantdioDneaodf dosing-days: 31 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyroEmxpnoescurroepsy Gross Pathology KIDNEYDSISCOLORATION, TAN, `LEFT. URINADRIYLABTLAATDIDOENR, RED. No MaLIcVrEoRs,copLiOcNGSA,bnoWrEAmRaTl,itySKEOLbEsTeArLveMdUS:CLE, SPLEEN, AORTA, BRAIN, CSEPCIUNMA,L CCOOLRODN,, STROEMCATCUHM,, MDUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODTEL,EUMS,ALIPVAANCRRYEAS, GSLCAINADTSI,C NMEARNVDEI,BULPAIRTULIYTMAPRHY GNLOADNE,D, THTYHWYURSO,IDAGDLRAENNDA,L GLANDS, PEYAER(AST)HYWRIOTIHD GOLPATNIDCS,NERTVREA,CHESAK,IN,ESOPPRHOASGTUAST.E, PHSAERMYIINXA/LLAVREYSNIXC,LES, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVERHY: PERTROPHY, CENTRILOBULAR, minimal. KIDNEYPSYSLONEPHRITIS, BILATERAL, moderate seLEENHYD RONEPHROSTS, BILATERAL, mild PHARYN`AKT/RLOAPRHYY,HKLY MPHOID, mild. PROSTAMITSESING. 646380 Continued onMItShSeINnGe.xt page .... - ~____________ `CompanySanitized.Doesnot conTtSaCAiC8n1 H9-02-4D7a6y8:GSauvbacgherSotnuidcy TinoxRiactistywith One-Generaton Reproduction Evaluations DuPont-5990 --_ INDIVIDUAL ANTWAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day sex: Males Animal Ref Microscopic & Macroscopic Findings 646380 Continued from previous page Histopathology : URINARIYNFLBALMAMDADTEIRON:, SUBACUTE/CHRONIC, moderate. . CAUSEHEOMFORDREHAATGHE, moderate. KIDNEY: INFLAMMATION/OBSTRUCTION No MiLOcNrGoSs,copWEiAcRTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edAORTA, BRAIN, SPINAL CORD. RSETCOTMUAMC,H, `WDEUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAANRCYREGALSA,NDSC,ECUMMA,NDCIOBLUOLNA,R LPYIMTPUHITANORDYE,GLATNHDY,MUST,HYARDORIEDNGALLANGDL,ANDPSA,RATSHCYIRAOTIIDC GNLEARNVDE,S, VTREASCIHCELAE,S, ETSEOSPTHEASG,US,GPIEDYIE(DSV)HIDWEIST,H OFPETMIUCR/KNENREVEE,JOISNKTI,N, STSEERMNIUNMA,L BONE NARROW, NOSE I & II, NOSE IIT & IV ORGANPSHARNYONTX/ELXAAMRIYNNEXD,: PROSTATE - 646380 KTeirlmliendalonSaDcary:ific1e23 AEnxipmoaslureisGrsoiugpned: o1f-fNonftrhomRenceocvreorpysy Gross Pathology No MaLcIVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDNST,ICWANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, 546384 Continued on the next page - 597 `CompanySanitized.Doesnot conTtSaCAiCBnI H.24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646380 Continued from previous page Gross Pathology No MTaHcYrRoOsIcoDpiGcLANADb,norPmAaRlAiTtHyYROOIbDserGLvAeNdDS:, TRACHEA, ESOPHAGUS, PSHEAMRIYNNAXL/LVAERSYINCXL,ES,EVEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE 2 Histopathology LiverHYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYISNFL: AMMATION, SUBACUTE/CHRONIC, FOCAL, minimal SPLEENNEP:HROPATHY, CHRONIC PROGRESSIVE, minimal. HPEIMGAHTEONPTOIIENSCIRSE,ASEIDN,CREmAiSnEiDm,alminimal THYROAILDTEGRLAATNIDON:, COLLOID, moderate - CAUSE`SOAFCRDIEFAITCHE BY DESIGN. sa6388 TKeirlmliendalonSDaacyri:fic9e5 AEnxipmoaslureisGrsoiugpne:d o5f0f-DafyromExnpeocsurroepsy Gross Pathology LIVERLA:RGE. 646388 Continued on the next page .... --- `Company Sanitized.Doesnotcontain TSCA CBI 9H02-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywithOne-Generation Reproduction Evaluations DuPont:5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings cas388 Continued from previous page Gross pathology No MaKcIrDNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y OSKbEsLeErTvAeLd M: USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PHINLOEDUEM,, GSLAALNIDVSA,RYSCGILANNTDISC, NEMRAVNED,IBUPLIATRUITLAYRMYPHGLNOADNED,, TTHHYYMRUOST,D GALDARNEDN,AL EPYAER(AST)HYWRIOTIHD OGLPATNIDCS,NERTVREA,CHESAK,IN,ESOPPRHOASGTUAST,E, PHSAERMYINNXA/LLAVREYSNIKC,LES, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, Histopathology LIVERHYPERTROPHY, CENTRILOBULAR, mild. KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. spLEENPIGHENT INCREASED, minimal. - THYROIHDEMAGTLOAPNODIESIS, INCREASED, minimal. AHLYTPEERRATTRIOPOHNY,, COFLOLLOLIIDC,ULAsRe,vermeil.d. CAUSESOAFCRDIEFAITCHE B: Y DESIGN. 646388 Continued on the next page ... -> CompanySanitized. Does notcontain TSCAC81 H24768:Subchronic Toxicity 90-Day Gavage Study in Rats with One.Generation Reproduction Evaluations DuPon-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 546388 Continued from previous page Histopathology : No MiLUcNrGoSs,copHEiAcRTA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edAO:RTA, BRAIN, SPINAL CORD, RSETCOTMUAMC,H, `MDEUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODET,LEUSMA,LIVPAANRCYREGALSA.NDSC,ECUMMA,NDCIOBLUOLNA,R : LPIYTMUPIHTANORDYE,GLATNHDY,MUSP,ARAADTRHEYNRAOLIDGLGALNADNSD,S. STCRIAACTHIECA,NEREVSEO,PHAGUS, . SPHEAMRIYNNAXL/LVAERSYINCXL,ES,BYEU(RSI)NARWYITHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, IFEIMUeR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE 646391 TKeirlmliendalonsaDcaryif: ic1e83 AEnxipmoaslureisGrsoiugnpe:d o3f-fMonftrhomRneeccorvoeprysy Gross Pathology + - No maLcIrVEoRs,copKiIcDNEAYbSn,ormSaPlLEiEtNy, OTbHsYeRrOvIeDd G:LAND, PARATHYROID GLANDS, TESTES Histopathology THYROAILDTEGRLAATNIDON, COLLOID, mild. CAUSE`SOAFCRDIEFAITCHE B Y DESIGN. No MiLIcVrEoRs,copKiIcDNEAYbSn,ormSaPlLiEtEyN Observed : - = Company Sanitized. Doss not contain TSCA C81 9H0L2-4D7a6y8:GavSaubgeehSrtoundiyc Toxicity in Rats with One Generation Reproduction Evaluations DuPont-5990 _ INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS Pose Group : VIT - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646397 TKeirlmliendalonSaDcaryif: ic1e23 - AEnxipnoaslureisGrsoiugpned: o1f-fYonftrhomRneeccorvoeprysy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,ve-dSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUvMM,bH NAODDREE,NAL"SAGLLIAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULPARITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIKD/LGALRAYNNDK,, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC. NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE. FSEEMMUIRN/AKLNEVEESIJCOLIENST,, USTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, Histopathology LIVER:HYPERTROPHY, CENTRILOBULAR, minimal -- KIoNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. spreeHnEM:ATOPOIESIS, INCREASED, minimal. THYROIPDIGGMLENATND:INCREASED, minimal. AHUYTPEERRATTRIOOPNH,Y, COFLOLLOLIIDC.ULAmRi,ld.minimal. CAUSESAOFCRDIEFAITCHE BY DESIGN. _-- Ed Company Sanitized.Doesnot contain TSCA C81 H9-02-4D7a6y8G:avSaugbecShrtoundiycTionxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day sex: wales Animal Ref Microscopic & Macroscopic Findings 646407 KTeirlmliendalonSaDcaryif: ic95e EAnxipmoaslureisGrsoiugnpe:d o9f0f-DafyroEmxpnoescurroepsy Gross Pathology = LIVER La: nce. No MaKcIrDNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y OSbKsEeLrEvTeAdL MUSCLE, SPLEEN, AORTA, PBRAANTCNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJULNYUM,PH INLOEDUEM,, GSLAALNIDVSA,RYSCGLIANNTDISC, NEMRAVNED,IBUPLIATURITLAYRVYPHGLNAONDDE,, TTHHYYMRUOSI,D GALDARNEDN,AL EPYAER(AST)HYWRIOTIHD OGLPATNIDCS,NERTVREA,CHESAK,IN,ESOPPRHOASGTUAST,E, PHSAERMYINNXA/LLAVREYSNIKC,LES, USRTIERNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, Histopathology _ LIVERHY: PERTROPHY, CENTRILOBULAR, mild KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, mild. spreePIG: ENT INCREASED, minimal `THYROHIEDNAGTLOAPNODTESTS, INCREASED, minimal. `HAYLPTEERRTARTOIPOHNY,, COFLOLLOLIIDC,ULAmRi,nimmailnimal CAUSESOAFCRDIEFAITCHE BY DESIGN. 646407 Continued on the next page . --- ee `CompanySanitized.Doesnot conTtSaCAiCBnI 9H0--2D47a6y8G:avSaubgcehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day sex: Males Animal Ref Microscopic & Macroscopic Findings 646407 Continued from previous page Histopathology : No MiLUcNrGoSs,copHiEAcRTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edAORTA, BRAIN, STOMACH, DUODENUM, JEJUNUM, TLEUM, PANCREAS, SCEPCIUNMA,L CCOORLDO,N, RLEYCMTPUHM,NOD`EM,ESETNHTYEMRUISC, LAYDMRPEHNANOLDEG,LANSDASL,IVASRCYIATGILACNDNSE,RVEM,ANDIBULAR PPHIATRUYINTXA/RLYARGYLNAXN,D, 'EPVAER(SA)THWYIRTOHIDOGPLTAINCDSN,ERVTER,ACHSEKAI,N, ESPORPOHSATGAUTSE,, FSEEMMUIRN/AKLNEVEESIJCOLIENST,, urs wv USTREIRNNAURMY, BLBAODNDEERM,ARRTOEWS,TESN,OSEEPIIDI&DYINI,IDENSO,SE 646413 TKeirlmliendalonSaDcary:ific95e AEnxipmoaslureisGrsoiugpne:d o9f0f-DafyromExnpeocsruroepsy Gross Pathology - No MaLAIOcVRrEToRAs,.copKBiRIcADINNEA,YbSn,oSrPmILaNUNAlGLiSt,CyORHODEb,AsReTrS,vTOeMdSAKCEHL,ETADLUODNEUNSUCML,E, JESJPULNEUEMN., NIOLDEEU,M, SAPALNICVRAERAYS,GLACNEDCSU,M, WACONLDOINB,ULARRECTLUYMM,PHMENOSDEEN,TERTIHYCMULSY.MPH ATDHRYERNOAILD GGLLAANNDD,S, PSACRIAATTHIYCROINDERVGEL,ANDPSI,TUTIRTAACRHYEAG,LANEDS,OPHAGUS. SFPEEHMMAUIRRYNW/ACKL/NLEVAEERSYIJNCOXIL,NETS,,EVEUS(RTSIE)RNNAUWRMIY,THBNLAOODPSDTEEIRC, NTEERSVTE,ES,SKIENP,IDIPDRYOMSITDAETSE,, 646413 Continued on the next page -... --- ee Company Sanitized.Doesnotcontain TSCA CBI 9H0--2D47a6y8G:avSaubgeehSrtoundiyc iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont 5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: males Animal Ref Microscopic & Macroscopic Findings 646413 Continued from previous page Histopathology LIVERHYPERTROPHY, CENTRILOBULAR, mild. spLEEHNEMATOPOIESIS, INCREASED, minimal. THYROIADLTEGRLAATNIDON, COLL.OID. severe EYE(S)HYWPEIRTTHROOPPHTYI,C FNOELRLVIECU:LAR, mild. PROSTAFTOLED/: ROSETTE, RETINAL, minimal. CAUSEIONFFLDAMEMAATTHIO:N, SUBACUTE/CHRONIC, minimal. `SACRIFICE BY DESIGN. No MiKIcDrNoEsYcSo,picLUNAGbSn,ormHaElARiTt,y OSbKsEeLrEvTeAdL MUSCLE, AORTA, BRAIN. CSEPCIUNMA,L CCOOLRODN,, STROEMCATCUHM,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANCRRYEAS, - GSLCAINADTSI,C WNEARNVDEI,BULPAIRTULIYTMAPRHY GNOLDAEN,D, THPYAMRUAST,HYARODIRDENGALLANGDLSA.NDS, UTRRAICNHAERAY, BLEASDODPEHRA,GUST,ESTPEHSA,RYNEKP/ILDAIRDYYNMXI,DESS,KINF,ENSUERM/IKNNAELE VJOEISNITC,LES, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646422 UDunrsacthieodnuleofd dSoascirnigf-idcaeys: 28 AEnxipmoaslureisGrsoiugnped: o0f-fDafyroEmxnpeocsruroepsy Gross Pathology : KIDNEYDSILATATION, LEFT, severe 646422 Continued on the next page -... -- ee `Company Sanitized. Doesnot contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont. 5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings sa6a22 Continued from previous page Gross Pathology : No MaLIcVrEoRs,copLUiNcGSA,bnoHErAmRaTl,itySKOEbLsEeTArLveWdUSCLE, SPLEEN, AORTA, BRAIN, . SCEPCIUNMA,L CCOORLDO,N, `SRTEOCMTAUCMH,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANCRRYEAS, GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS. SPCAIRANTTIHCYRONEIRDVEG,LANPDIST,UITTRAARCYHEGRL,ANDE,SOPTHHAYGRUOSI,D GPLHAANRDY,X/LARYNK, UEYRSI(NSA)RYWIBLTAHDDOEPRT,ICTENSETREVSE,, ESKPITND,IDYPMRIODSETSA,TE,FESNEUNR/IKNNAELEVEJSOIINCTL,ES, STERNUM, NOSE Histopathology LIVERHY: PERTROPHY, CENTRILOBULAR, minimal. KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROIHDYDGROLNAENPDHR:OSTS, UNILATERAL, severe. --_ AHLYTPEERRATTRIOOPNH,Y, COFLOLLOLIIDC,ULAmRi,ldminimal. CAUSEKIODFNEDYE:ATHINFLAMMATION/OBSTRUCTION No MiLUcNrGoSs,copHiEcARTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL `CCOORLDO,N, "SRTEOCMTAUCMH,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANCRRYEAGSL,ANDCSE,CUM, NMEARNVDEI,BULPAIRTULIYTMAPRHY NGOLDAEN,D, THPYAMRUAST,HYARDORIEDNAGLLANGDLSA,NDST,RACSHCEIAA,TIC 646422 Continued on the next page ... EE `Company Sanitized. Does not contain TSCA C81 H-24768: Subchronic Toxicity 90-Day Gavage Sty in Rats with OneGeneration Reproduction Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 6a6az2 Continued from previous page Histopathology No MiEScOrPoHsAcGoUpSi,c APbHnAoRrYNmXa/lLiAtRyYNOKb,serEYvEe(dS) WITH OPTIC NERVE, SKIN, PSRPOISDTIADTVEM,IDESSE,MINFAELMUVRE/SKINCELEESJ,OINUTR,INASTREYRNBULMA,DDEBRO,NETEMSATRERSO,W, NOSE I&II, NOSE IIT & IV v 645428 TKeirlmliendalonsaDcaryi:fic1e23 AEnxipmoaslureisGrsoiugnpe:d o1f-fNonftrhomRneeccorvoeprysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt.y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC.OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYYM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDNST,IC`MNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND.THYMUS, PN TPHHAYRRYOIIVDG/GLLAARNYDN,K, PEAVREA(TSH)YROWIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, `FSEEMMUIRN/AKLNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, Histopathology : KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. sevenHEMATOPOIESIS, INCREASED, minimal. 646428 Continued onPIthGeUENnTextINpCRaEgAeSE.D.,.. minimal 506" Company Sanitized. DossnotcontainTSCA CBI F-24768: Subchroric Toxicity 90-Day Gavage Sudy in Rats withOneGeneration Reproduction Evaluations DuPon5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings sa6azs Continued from previous page Histopathology : THYRO`IADLTGELRAANTDION:, COLLOID, moderate. CAUSEHOYFPERDTERAOTPHHY, FOLLICULAR, mininal SACRIFICE BY DESIGN. No miLcIrVoEsRcopic Abnormality Observed 646433 KTeirlmliendalon SaDcaryif: ic9e5 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsruorepsy Gross Pathology LIVER LA: RGE. - No MaKIcDrNoEsYcSo,picLUNAGbSn,ormHaEAlRiTt,y OSbKsEeLrEvTeAdL M: USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TEJREIJCUNLUYMM,PH INLOEDUEM,, GSLAALNIDVSA,RYSGCLIAANTDISC, NEMRAVNED,IBUPLIATRUITLAYRMYPHGLNAONDDE,, TTHHYYMRUOSI,D AGLDARNEDN,AL EPYAER(AST)HYWRIOTIHD OGLPATNIDCS,NERTVREA,CHESAK,IN,ESOPPRHOASGTUATSE,, PHSAERMYINNXA/LLAVREYSNIKC,LES, USTREIRNNAURMY, BLNAoDsDEER, TESTES, EPIDIDYMIDES. FENUR/KNEE JOINT. 66433 Continued on the next page .... --- `CompanySanitized. Doesnot conTtSaCAiCBnI 9H0--2D47a6y8G:avSaubgeehSrtoundiyc iTnoxRiactistywithOne.Generation Reproduction Evaluations DuPont5990 --- INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: VII - 500 mg/kg/day Sex: wales Animal Ref Microscopic & Macroscopic Findings 646433 Continued from previous page Histopathology : LIVERHY: PERTROPHY, CENTRILOBULAR, mild. serEeNPIGMENT INCREASED, minimal. `THYROHIEDMAGTLOAPNODTE:STS, INCREASED, minimal. . `HAYLPTEERRTARTOIPOHNY,, COFLOLLOLIIDC,ULAsRe,vermei.ld. EYE(S)FOWLID/TRHOSOEPTTTIEC, NERERTVIENA:L, minimal. CAUSESOAFCRDIEFAITCHE BY DESIGN. No MiKcIrDNoEsYcSo,picLUNAGbSn,ormHaEAlRiTt,y OSbKsEeLrEvTeAdL M: USCLE, AORTA, BRAIN, CSEPCIUNMA,L CCOOLRODN,, STROEMCATCUHM,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANCRRYEAS, SGLCAINADTSI,C NMEARNVDEI,BULPAIRTUILTYAMRPYH GNOLDAEN,D, THPYAMRUAST,HYARODIRDENGALLANGDLSA,NDS, - VTERSAICCHLEEA,S, ESUORPIHNAAGRUYS,BLAPDHDAERRY,NK/TLEASRTEYSN,X, EPSKIIDNI,DYMPIRDOESST,ATEF,EMUSRE/MKINNEAEL JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE 111 & IV 646437 KTeirlmliendalonSaDcaryif: ic9e5 AEnxipmoaslureisGrsoiugnped: o9f0f-DafyromExnpeocsruroepsy Gross pathology SKIN ALOPECIA, PERINEUM 686437 Continued on the next page -... rT CompanySanitized. DoesnotconTtSaCAiC8n1 9H0-2-4D7a6y8:GavSaubgcehSrtoundiyc iTnoxRiactistywithOne-Generation Reproduction Evaluations DuPon5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day sex: wales Animal Ref Microscopic & Macroscopic Findings 646437 Continued from previous page Gross pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANDODREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,ICMANNEDRVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND.THYMUS. TPHHAYRRYONIXD/LGALRAYNNDK,, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAP,ROSETSAOTPEH,AGUSSE,MINAL VJOEISNITC,LESS,TERUNRUIMN,ARNYOSBELADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE Histopathology : LaverHYPERTROPHY, CENTRILOBULAR, mild SPLEEHNEMATOPOTESIS, INCREASED, minimal. THYROAILDTEGRLAATNIDON:, COLLOID, severe. --_ SKIN:HYPERTROPHY, FOLLICULAR, mild. CAUSEALOOFPEDCETAAT/HHY:POTRICHOSIS, minimal `SACRIFICE BY DESIGN. 646437 Continued on the next page .... --- Company Sanitized.DoesnotconTtSaCAiCBnI H902-4D7a6y8:GavSaugbeehSrtoundiyc iTnoxRiactistywithOne Generation Reproduction Evaluations DuPont-5990 ~ INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646437 Continued from previous page Histopathology + No MiKIcDrNoEsYcSo,picLUNAGbSn,ormHaEAlRiTt,y OSbKsEeLrEvTeAdL M: USCLE, AORTA, BRAIN, CSEPCIUNMA,L CCOOLRODN,, STROEMCATCUHM,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANRCYREAS, . SGLCAINADTSI,C WNEARNVDEI,BULPAIRTUILTYAMRPYH GNOLDAEN,D, THPYAMRUAST,HYARDORIEDNGALLANGDLSA,NDS, ETYREA(CSH)EA,WITEHSOPOHPATGIUCS,NERPVHEA,RYNPKR/OLSATRATYEN,X, SEMINAL VESICLES, SUTREIRNNAURMY, BLBAODNDEERM,ARRTOEWS,TESN,OSEEPIIDI&DYIMI,IDENSO,SEFEIINIUR/&KNIEVE JOINT, 646402 TKeirlmliendalonsaDcary:ific95e AEnxipmoaslureisGrsoiugnped: o9f0f-DafyromExnpeocsruroepsy Gross pathology + Ps No MaLcIVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC.OLOSNT.OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND.THYMUS. TPHHYARRYONIXD/LGALRAYNND,X, PAEVREA(TSH)YROWIIDTHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMUIRN/AKLNVEEESIJCOLIENST,, USTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, 646442 Continued on the next page . mw `Company Sanitized. Doesnotcontain TSCA CBI H9-02-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPon-5990 - INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 6asaaz Continued from previous page Histopathology LIVERHY: PERTROPHY, CENTRILOBULAR, mild. KIDNEYISNFLAYMATION, SUBACUTE/CHRONIC, FOCAL, minimal SpLEENNEP:HROPATHY, CHRONIC PROGRESSIVE, minimal. PHEIMGAMTEONPTOTIENSCTRSE,ASEIDN,CREmAiSnEiDm,al.minimal THYROIADLTEGRLAATNIDON, COLLOTD, moderate. CAUSEHOYFPERDTERAOTPHHY:, FOLLICULAR, minimal SACRIFICE BY DESIGN. No miLcUNrGoSs,copHiEAcRTA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edAO:RTA, BRAIN, SPINAL CORD, RSETCOTMUAMC,H, MEDUSOEDNETNEURMI,C LJEYGMUPNHUMN,ODEI,LEUSMA,LIVPAARNYCREGALSA,NDSC,ECUMMA,NDCIOBLUOLNA,R - LPYIMTPUHITNAORDYE,GLATNHDY,MUSP,ARAADTRHEYNRAOLIDGLGALNADNSD,S, STCRIAACTHIECA,NEREVSEO,PHAGUS, SPHEAMRIYNIADLU/VLEASRIYCNXL,ES,EVEU(RSI)NARWYITHBLOADPDTEIRC, NTEERVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FoErMURe/KwNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE - `CompanySanitized. Doesnot containTSCAC81 H24768: Subchronic Toxicity '90-Day Gavage Study in Rats withOneGeneration Reproduction Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 me/ks/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 6a6aas TKeirlmliendalonSaDcaryif: ic1e23 AEnxipmoaslureisGrsoigunped: o1f-fNonftrhomRenceocvreorpysy Gross Pathology No MaLcIrVoEsRcopKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,N'ASLALGILAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNNDK,, `EPYAREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRAVEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEENMUIRN/AKLNVEEESIJCOLIENST,, USRTIERNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, Histopathology LIVERHY: PERTROPHY, CENTRILOBULAR, minimal. PN KIDNEYFSATTY CHANGE, MEDIAN CLEFT, minimal. SPLEENNEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PHEIMGAHTEONPTOIIENSCIRSE,ASEIDN,CREmAiSnEiDm,alminimal `THYROAILDTEGRLAATNIDON:, COLLOID, severe. causeHYOPFERDTERAOTPHHY, FOLLICULAR, minimal. SACRIFICE BY DESIGN. on `Company Sanitized.Doesnotcontain TSCA C81 HL24768: Subchvoric Toxicity 90-Day Gavage Study in Rats with OneGeneration Reproduction Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: VII - 500 mg/kg/day sex: wales Animal Ref Microscopic & Macroscopic Findings 646466 KTeirlmliendalon SDaacyr:ific1e83 AEnxipmoaslureisGrsoigunped: 3of-fMonftrhomReneccorvoeprsyy Gross pathology . No MaLcIVrEoRs,copKiIDcNEAYbSn,ormSPaLlEiEtNy, OTbHsYeRrOvIeDd G: LAND, PARATHYROID GLANDS, + TESTES Histopathology KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal THYROAILDTEGRLAATNIDON:, COLLOID, severe. CAUSEHYOPFERDTERAOTPHHY:, FOLLICULAR, minimal. SACRIFICE BY DESIGN. No MiLIcVrEoRs,copSiPcLEEANbnormality Observed sa6a7a KTeirlmliendalonSaDcaryif: ic1e23 EAnxipmoaslureisGrsoigunped: 1of-fNonrtohmRneeccorvoeprsyy Gross pathology : No MaLcIVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKELETAL MUSCLE, SPLEEN. AIOLRETUAM!, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULPARITLUYIMTPAHRYNOGDLEA,ND,THYMUS, 646474 Continued on the next page -... --- ws CompanySaniltized.Doesnot conTtSaCAiC8n1 H-24768: Subehronic Toxicity 90-Day Gavage Stedy in Rats withOne.Generation Reproduction Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: VII - 500 mg/kg/day Sex: wales Animal Ref Microscopic & Macroscopic Findings pre Continued from previous page Gross Pathology No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDerGvLAeNdDS:, TRACHEA, ESOPHAGUS, SPHEAWRIYNIAXL/LVAERSYINCKL,ES,EEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology + LaverHYPERTROPHY, CENTRILOBULAR, minimal. seLEEHNEM:ATOPOTESTS, INCREASED, minimal THYROIPDIGGHLENATNDIN: CREASED, minimal. AHLYTPEERRATTRIOOPNH,Y, COFLOLLOLIIDC,ULAmRi,ld.minimal. CAUSESOAFCRDIEFAITCHE B: Y DESIGN. -_ No miKcIDrNoEsYcSopic Abnormality Observed : 646475 KTeirlmliendalon SaDcaryif: ic9e5 AEnxipmoaslureisGrsoiugpne:d o9f0f-DafyroEmxpnoescurroepsy Gross pathology srownUcLCE:R/EROSION, GLANDULAR, FEW, minimal 646475 Continued on the next page -... as `Company Sanitized. Doesnotcontain TSCA C81 H902-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPon5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males * Animal Ref Microscopic & Macroscopic Findings 646475 Continued from previous page Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, APOARNTCAR,EASB,RAICNE,CUNS,PICNOALLONC,ORDR,ECTDUUMO,DENMUEMS,ENTJEEJRUINCUML,YMPIHLEUNMO,DE, . GSLAALNIDVSA,RYSGCILNATNIDCS NMERAVNED,IBUPLIATRUITLAYRWYPHGLNAONDDE,, TTHHYYMRUOSI,D GALDARNEDN,AL EPVAER(AST)HYWRIOTIHD GOLPATNIDCS,NERTVREA,CHESAK,IN,ESOPPRHOASGTUAST,E, PSHEAMRYINNXA/LLAVREYSNIKC,LES, SUTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, Histopathology : LIVERHY: PERTROPHY, CENTRILOBULAR, mild. KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal spLEENPIG NENT INCREASED, minimal --_ `THYROHIEDNAGTLOAPNODTE:SIS, INCREASED, mild. `HAYLPTEERRTARTOIPOHNY,, COFLOLLOLIIDC,ULAmRo,dermaitled. BYE(S)OPTWIICTH NEORPVTEICNONTERVPERES: ENT. CAUSHEEOMFORDREHAATGHE:INFLAVMATION (BLEEDING PROCEDURE). SACRIFICE BY DESIGN. 546475 Continued on the next page .... ois`CompanySanitized. Doesnot conTtSaCAiCBnI H9-02-4D7a6y8:GaSvuabgcehrSotnuidcy iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont 5990. ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646475 Continued from previous page Histopathology : No MiLOcNrGoSs,copHEiAcRTA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edAO:RTA, BRAIN, SPINAL CORD, SRETCOTMUAMC,H,`MDEUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODET,LEUSMA,LIVPAANRCYREGALSA,NDSC,ECUMMA,NDCIOBLUOLNA,R PLYIMTPUHITANROYDE,GLATNHDY,MUSP,ARAADTRHEYNRAOLIDGLGALNADNSD,S, STCRIAACTHIECA,NEREVSEO,PHAGUS, PBLHAADRDYEVRN,X/LTAERSYTNE,S, SKEIPNI,DIDPYRWOISDTEAST,E, FESMEUMRI/NKANLEEVEJSOIICNLTE,S, STUERRINNUAMR,Y BONE MARROW, NOSE I & IT, NOSE ITI & IV sa6asa TKeirlmliendalonSaDacyrif: ic1e23 AEnxipmoaslureisGrsoiugpned: o1f-fNonftrhomRneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, --_ AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NA'LSALGILAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULPARITLUYIMTPAHRYNOGDLEA,ND,THYMUS. PTHHAYRRYONIXD/LGALRAYNDN,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEEESIJCOLIENST,, USTREIRNNAURMY, BNLOASDDEER, TESTES, EPIDIDYMIDES, 646484 Continued on the next page ... _-- `Company Sanitized.Doesnot contain TSCA CBI 9H-02-4D7a6y8:GSauvbagcehrSotnuidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPont.5990 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings prem Continued from previous page Histopathology KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal seLEaHNEM:ATOPOTESTS, INCREASED, minimal THYRPOIIDGUGELNATN.DIN:CREASED, minimal. AHLYTPEERRATTRIOOPNH,Y, COFLOLLOLIIDC,ULAsRe,vermei.nimal CAUSESOAFCRDIEFAITCHE B: Y DESIGN. No MiLcIrVoEsRcopic Abnormality Observed : -_-- is CompanySanitized. DoesnotconTtSaCAiCBnI