Document vg0eLpYR1xxoY6BnjB7ZQrZ8

COPY THE CEILDB.Eu 1S HOSPITAL RESEARCH FOOHDAIIQH CLSCIKHATI, OHIO October 24, 1952 Er. Elston L. Belknap 201 West Wisconsin Avenue liilwaukee 0, 'Wisconsin Dear Dr. Belknap: Rumors seem to fly far and fast. I do not feel that we are in a position to say very much about the possible dangers of Versene therapy in lead poisoning from a very limited experience. To be very brief, in two dramatically ill small children with symp toms of le-.c oneephalopathy v/o did try Versene therapy very briefly. In both instances we were led to stop the therapy be cause of the development of hypertension. With one child the blood pressure rose to 170/150 and in the other to 150/120. The first child exhibited some hyp ertension, 120/80, before Versene therapy was started, With the other chile no blood pressure r riding is found, in the record for the pro-treatment pressures. There is, however, a st..lenient that the pressure was normal before treatment was started and returned to normal rapidly ..tsr treatment was discountinued. The first child died and pros ly would have died whether or not Versene therapy was usee. Ins ether child survived. b'e do not intend to puoiish this experience because it is in adequate. Rather, I on giving the complete case nistorios to Dr. Robert Kenoe of the Kettering Laboratories here in Cincinnati, Dr. Kenoe v/iii see that the experience is distributed in the proper slice. Obviously the management of acute lead encephalo pathy in small children presents a very different problem from that of chronic lead intoxication in the adult. Personally I have not given up the idea of further trial with Versene therapy but before using it again will want to see the accumulation of more experimental work in connection with what can be expected. Such work is now underway in Dr. Kehoe's laboratory and prchaoly in other places, : '" With best regards to a former schoolmate, Sincerely yours, AAW:JP A. , Weech, k.D. Hi 000*3