Document vVOLwDB8vMVEKB7rgewn2JqLZ

COTTER-COTTER--CADMIUM POISONING SOI The abnormalities of the blood chemistry in this case indicated that both liver and kidneys had been injured. The injury is attributed to the cadmium rather than to the lead absorbed. Lead may, however, have played a role in the production of the bone marrow changes. j abnormal cholesterol ratio high serum globulin f high serum nonprotein nitrogen Kidneys -j high serum uric acid ^albumin and casts in urine _ (anemia Bone marrow-'. ) ,basop.h..il.ic stippling Table 10.--Laboratory Data After Three Months Substance or Test Amount or Reaction Blood sugar ............................................................................................................. Serum nonprotein nitrogen........................... ;..................................................... Serum phosphorus .................................................................................................. 101 21 mg./lOOcc. 3.4 Serum alkaline phosphatase 3.2 Bodanskj" units/200 cc. Serum total protein Serum albumin ___ Serum globulin....... 7.2 4.1 <3m./100 cc. 3.1 Serum calcium :................................ . Serum carbon dioxide............. ,___ Serum halogen ................................... Serum sodium ....................... ......... . V Blood lead .;....................................... Urine lead .;............................. ;......... 5.1 23.1 106 140 mEq./l. None None Blood cadmium ................................ . Urine cadmium ....... ........................ None None Albumin and microscopic changes. None Hematological Findings R. B. 0. .................................... Hgb. .............................................. W, B. C....................... ................ Differential count Neutrophils ........................... Lymphocytes ...........1____ Monocytes ............................ Basophils ............................... No stippled cells 4,800,000 16 Gm. .6,100 Case 4.--J. A., a 2d year old white man, had been employed at pulverizing cadmium sulfide for a year. He neglected to wear the mask provided, because it was uncomfortable. A cough developed, and a yellow tinge to his skin, which he thought was due to the cadmium yellow. On physical examination he had a slight icteric tint, a harsh cough and rapid respirations. He was expectorating-.blbod-tinged, frothy sputum, and his chest was full of rales. The labora tory findings may be seen in table 9. After three days his chest signs cleared up. The jaundice lasted a week. He returned for reexamination at the end of three months, feeling fine. He had undergone no further cadmium exposure in the interim. The laboratory findings at this time appear in table 10. nj This is another case in which absorption and excretion of both lead and cadmium were demonstrated. Jaundice was an interesting clinical finding. The chest findings were more I