Document vVBw7p2O1jmJrw09y8dmOKNBq

curmlngtonlte la the gold-bearing eehlota (Table 5, Study IV, V).7 Studies II and V show no evidence of asbestos-related dlseaaea appearing in the study groups. { Mortality canpariaana, trqiea va. mines. The cancer mortality pattern for those In the aabeetea trades and mining occupations la graphically presented In Figure 8, where lung cancer Mortality Is plotted vlth respect to mortality due to mesothelioma. The studies of the ri|M Cr*9*Sci mwftt-- mt thm ^npartlaatl aorulltr 4m tm || CMCir *a4 M(hUw ftr CM MktM mdrt wrktra T<bU 4, ItWlo 1-1))* tN i>b8tM letrt mmi aUUri C1m#,b MU 5, S(4Ua cM m\m f*l*tiodi mt tM Sifld) irta mt Svlttcrlacrf, mni tin agU fapwljitoai mt (lva nattMi 4) KtrtiutM mlytlt ( M coredIcy C tte ciUatot ttiCtt or%rc (St41 1-4, H)) {Mr* a yoclctc corvalailaa Mcwcco CM too ^livawa; 74 ^rm( ot CM varl* --cm (d) of lw| cdactf to itcaaaiH for %y mooCM1Iom TM rtmilo Un ta f cM foroi ftamdollaac) *2.94 0.444s (tig caacac). TM latatctfi it f 0 ! 4.4 H(cnt long cancer* a raaaoMUl aatiaaW ( cortaltcy for tfcla Ctaaaao If. tM Mitt.aMctot cra4a aortata M Mate motkmi with aaWataa Me Mi ratalM cHtlr aaoklng Study V (McDonald et at.. 1978) discredits Study IV (Gillen at al., 1976). Study IV vas accomplished on e sub-cohort of the Study V cohort. The lotter study la ouch sore complete; statistically It Is baaed on 631 deaths, vhcrcos Study'IV Is based on 71 deaths. In addition. Study IV presents an Implausible mortality pattern: (1) No deaths due to silicosis, tuberculosis, or slllco-tuberculosia wore reported, despite the fact that the cluing company has been coping vlth a quarts dust problem for a cen tury, and (2) a 14*1 percent respiratory cancer mortality (Incorrectly Included as respiratory cancer vera a sinus and a mediastinal carcinoma) vas attributed to "cuamlngtonlte asbestos," yet no mortality due to asbestosls vas reported. The cuoalngtonlte found In the quartz-cuamlngtonlte schist host rock Is not asbestos, but rather garden-variety, rock forming omphlbolo. 310 asbestos trades workers (Table 6; Fig. 8, solid circles) shov a very sig nificant excess of mortality due to mesothelioma relative to that found In the miners (Table 5, Fig. 8, open circles) -- vlth one exception, the crocidollte miners of Western Australia (Study VI). For the asbestos trsdes workers a disease correlation Is^evident. Neglecting Study 5 (Table 6, Fig. 8), which is somewhat anomalous, regression analysis of the twelve trades data points (Studies 1-6, 6-13, Table 4, Fig. 8) shows a positive correlation between lung cancer and mesothelioma mortality; _2 78 percent of the variance (r ) of lung cancer Is accounted for by mesothelioma. Part of the remaining variance (22Z) can be accounted for by Inter-cohort differences In prevalence of cigarette smoking. This Is because the smoking habits of asbestos workers seem to greatly Influence Che lung cancer incidence but not mesothelioma Incidence. In regard to high mesothelioma mortality. It Is Important to note Che health studies of two groups of specialized factory vorkcra who, during World War II, vero employed at the task of placing crocidollte filter pods Into gas mask canisters. One group working In Canada, com posed of 109 men and 90 women, suffered 12.3 and 16.1 percent lung esneev and mesothelioma mortality, respectively (McDonald end McDonald, 1978). A second group of 1600 people, mostly women, vera employed at this sane task at a factory In Nottingham, England. Jones it al. (1976) reported that 26 mesothelioma deaths have occurred in this group; 23 were women. A large number of workers In these two groups vere exposed to asbestos only during this brief World War II work period. The high proportion of women vlth their more moderate Banking habits in the gas mask worker cohorts would suggest that the ratio of mesothelioma to lung corner (1.3 for the Canadian group) would be higher than that observed in the more typical "tradea" cohorts (Table 4), where the ratio averages 0.44 (Fig. 8). With the exception of the crocidollte miners (Study VI), the mor tality patterns of the hardrock miners (Studies.II, V), the tunnel workers (Study III), the asbestos miners (Studies I, VII-IX), and the ehrysotllo factory workers (Study 13) is quite different from that of the "trades" (Studies 1-12). The most apparent difference betveen the "trades" cohorts and these miners, tunnel workers, and chrysotllc factory workers Is the relative Incidence of mesothelioma. The latter groups,- 311 PRODUCED BY FORD