Document vV2nEBwEejkVLXgBQRZ2V34R9

Copies to: E I. du Font de Nemours and Company Haskell Labt .atory for Toxicology and Industrial Madicine HASKELL LABORATORY REPORT NO. 960-76 MR NO. Haskell No. 10,'fe'42---- Other Codes sample Heady for Testing 9-28-76 _ac_k_so AR226-2853 ACUTE ORAL TEST Procedure: The test material, as an aqueous solution, was administered by intragastrie intubation to adult ChR-CD male rats in single doses,;one animal per dose level. Survivors were sacrificed 14 day Results: Dose (ing/kg) Solution (%) Men-tality** Clinical Signs 25,000* 90 D - 2 d. Lethal Dose: Drowsiness on day of dosing, an 17,000 70 S - 14 d. lethargy and weight loss on the day after dos 11,000 70 S - 14 d. ' ing. 7,282 30 S - 14 d. 4,713 30 S - 14 d. Sublethal Doises: Weight loss for 1-3 days 3,219 30 S - 14 d. artt? dosing at 4,713 nig/kg and above. 2,250 10 S - 14 d. 2,141 1,401 670 30 S - 14 d. 30 S - 14 d. 10 S - 14 d. ^^BmPha --------1-------------- Summary s very low toxicity w'.ien administered orally to young adult ChR-CD male rats in doses; its ^oproyimate Lethal Dose (ALD) is 25,000 mg/kg of body weight. T Composition *** Administered D- 0 d. = S - ( ) d. -' CVFidhg as a divided Found dead ( Sacrificed ( dose. ) days ) days Date Issued; December 17, 1976 after affcer dosing. dosing. Approved by: ^ e ^ L ^Cihhaarleas - Research '/xU^^xw ------' 1 A. rJJiJte Chlfcf, Oral T ompany Sanitized.