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Respir Evaluation of respiratory effects in miners and millersBritish Journal of Industrial Medicine 1982;39:233-238 mental New exposed to talc free of asbestos and silica iratory D H W EGM AN, J M PETERS,* M A R YANNE G B O U N D Y ,t A N D T J SMITH iAnmfirJe FHreoamlththSeciOenccceusp,aHtiaonvaarldHSecahltohoPl orofgPraumbl,icDHeepaalrtthm, eBnotsotofnP,hMysaisoslaocghyu, saenttds t0h2e1D15e,paUrStmAent o f Environmental iscianinNei. kHeerasl.th2 nmromDiies .dhermonioicl unities. r>euprruisnee. jI| jI I' | setsTfCaoritrhtmxnoheruobeoatsmodesgeubmp1sktyrrenie2riareitcnnwahaascdsigtaltcttaueiuoietttfrobrairrdfeoneynej)sines,oerMdbplcdeeufeotiienfisrwvrsnftfsfccaeewoeeweettctrrhoheshhtscareaselaoowy.onldnansocneenAnscnshrgpymdleeeeceumr.vshrsodetimeteTnpk.deuprstihiiAdtenolcpstelrytmmrhgeareiaorraoedoaosdtntdqnkfiwesaaotuode-htnga1dfeytteerdos1rsesxattci6aebeaidppitorgvlhueohcsnwaiettsufsdnereouooberdsearlrrrhjnmtlaikeoetertocteec,woieeewcsnrt,so.-sfseceourusoPideifghipwlfmundeaasahlcelrmpvmnbolafveeulrseatetoaedostlnlbcexilmeusdoauepdprasefrerooimtnynrarusitFetooshuonfinEbanmuferkdtifeVeneifewsnomddect,tergcrtua.ooifytassosiPfedbr,ntendpoirucdacflpeettviehngerbuvaFdewdfauylelosVaflueltatrssttBrCeemrhiireslroraeiaoencirgaigtadpdraesritrdsia,eoetshesjocahuaugxawnitetrctpsfeMeeietahroetrir1.pnissee0amhtugtds3h(hyriepeactaf,exsehnoaonsuaarirl.fsfnbmeputNcRdxjwhriseipnegoeiiecloldeseaitlinmecsdcirnnc.atleieieter1tttOefadteice/odae0rdhd.frl csttSadttmtmpaiooauhsteollmiiuogbrcpniennongydeoxseeineedsniisssaestseiauiamocstatsarnsss.nn<etpit,trjndrdshcn>i,eceaofaamtsomnenltttpbnhmhdtigiiolaeilerrltpltsaiasaohnhlcwtdcirtaoecchaeetonvraoahpueryedlmttrertskreaheeydptelwissmhcrmaee.oessbnn1fibmrpn3fyitroeke-eaea1emtcadir5thlsretlhapppsmnAeliboaaslvrooe.pymaisfnfyraptutSotuoeoecnel.idnurdatxxneymtnpyTpuctiitoohesonmewhsstnasneauaoutVoVtstesrcrfeeeexeoeoeuxrrptfonnmtmphiofionVtdoeosooovtesesesthnnreeuidraessttstmrlaitccoleeikatitoo1ngcmaanennaltallnd1yocct,2 arneTsdphitreyaprtoersoyefadrecixshpeaowssaeusriednetsotihgetnalewcd,orttookidansegsteepsrosmptiuhnleeatetixhotnee,nletavnoedlf o`fPrPerseevnetnatidvdereMsse:diUcinniev,erLsoitsy AonfgSeoleust,heCrAn C90a0li3fo3r,nUiaS. AD.epartment Present address: Setauket. NYI 1733, USA. 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smoked and pack years produce the expected effect 236 Wegman, Peters, Boundy, Smith Table 2 Cohort of talc miners and millers (1975): pulmonary function by smoking variables Years smoked TN<F2P10o0e31-t-v0a021el99r P0TP2>F1a0o6-1c-t0a6k9l0years No 1222211176864 12232169386 FEV% 1<99889009455241------00336666182 <998890987742-------0332069144 FVC% 11>99990050768000----65092760601 1999909660080------8240940852 F-F-VE--CV- x 00 <77877702298607--08185 <787770922606-04123 MMEF <874675160176912------0-5826923183 <6775510699116-----0522521181 Table 3 Cohort of talc miners and millers (1975): pulmonary function by exposure variables Talc years No FEV% FVC% T<6FP31121o2-16t5-a852--l-174128--46 1221311535926* 199898047282201------09383764549 YT<FP513e-o5-0a92t-ra01sl9worked 14311135959* 999987225001---1420569268 Years worked was noi recorded for one individual. 199999047798100------84135790880 999998878006----0585800701 FF--VE--CV--x 100 <87777702820697--08185 < 0000006077176719416869 MMEF% <86567505926730-------50353278137 <766560414660-----7109212169 No 38211128672 2831173880 RV% >22222209305651-----55218328802 <223210747787-------01486030313 Table 4 Cohort of talc miners and millers (1975): comparison of exposure and smoking variables Talc years No FVC% FEV% FEVIFVC Non-smokers 66-2255 1160 19084--90 9999--08 00-8717 C<u2r0rent smokers 20 6666-22225555 21112343 99999446---7472 99983411----5996 0000---87761769 E<x2-0smokers 20 6666--22225555 16903 1199008106---3537 199807360--8692 0000-87765747 MMEF% 8732--36 46863800---1154 94675720---6420 (( ( I i ( ( Evaluation o f respiratory effects in miners and millers 237 Table 5 Cohort of talc miners and millers (1975): smoking and exposure variables by x-ray examination X-ray abnormalities No Years smoked Pack years Talc years Years employed SSmmPAPAPPaa**rrblbleellsssseireeeronnnnruttettngdulaorpaocpiaticeisties 8182 919 N1177S--33 N2136S--28 33N33S-09 35N11S--28 5128890---83003 61<09072---08001 1705---80501 <1077---09301 V lesi for difference in mean values. wasawosipidwrfshamnnmuubbptelenaeagaueinbpLfnnarasvn/uttidycjeoleconooeuwrnleitorirrrneaea1ictotorf-bommds9illtgedftoen-seid.oid2sapidualtett3flfuhelFlhihlrnefnhiiiaacuapdtedtneiedjapyrqvisdisunedern,ueheuestsldoemcpalrmapb.ehntonpoalbiuslsaeeTereoflogsp.lntyavnoutnearmaatdovemotrtnhalrsereyp.can5pdreeivdeNlhrsyllnfaytyes.rocmr1dceaomelufeore2huriubSanagorfrnsoyanfrneFuaekrsitukmtsvuclleocrhEeioaseetoelrbdiaweaiVrfrrrpamnojlatdsatcbaeoo,nsephnalicsr--npdogtloeglottiehoaionafsaflptureFrwecarfistawarbnmesiesehitadscrreootttwiiea;lhthiatiaetrcbothselwnnmsoiiftiegsiaetohtggsleswryhastaeu(aeeimeaetlcethbrnldapekoopawwiinorbhslpehnlfoearaloh1wilnuagpce2els9risridlliicux5mnycmtmto5hpahuphla,gub)aaonlodntea,.enltlonbdukcinfuuiTidnaotaootsigrniinnee4eae5urtnleaetlnhdddd17lgyrs-ssl misaipactwcviecspewpttnaiamhionbayrhxangaalaablemCc/aonEmorcpantrvpplsrylklhinsuvnteeoliiy.esaenspiisfryisgeagsrtcniTisiv-yfoty.reegealcf.eusooici2erehndaaTsncesrl4umoidadieaotmneaorcninaImenurrrfestflntsntbiseailelddlccoFoumypfpupnvlrroadsyrsnenaaEanetteoeuefoynooaanttgrsrmgrn6mdVwmmattplledact.etbilfefpedaoinamgcfprueuresdanfsyuslrneovtaaneninawoteegbtslatmrcarr.cidiasemhoeheenlictanyotemutrvrpionlaiihN,nnysofosyoaaslwat1eeintuwetnletannesh9rFauaedisain.odomggo7etrndyfaeEl3dhrnfseBv5nxmfttlpoVdiepoae,0opauooaeamlrprrrwr.hsl,oaomttsnmce,esthlhblytsewo--sFethpuwocoregepghmdptEeepuledrssf/ihmaTeoeramrteaerVspsseoyceakchrc.usua3rss,eftotieakhebronoe.neldoWnmpv-cmoe(nurmsddfytEo6pnawyeptndihneorr2levdeqepxeadaueoeenrnadipauxatrnrsrddeeartmacoeptpepslsiu.reokpianistsdiortllydnarreautaA)shtesbyelaianrrfcwsuseonyeelbtubeasedektnroeaoidepnlunnhwetseear--flhoytoyyctoseihrwwrtevdtsetmuv,aanhihtaeOtatafuioigennehvhtoopnterrrslnhdhndhoeaeerstrsst eT1x9ap7bo6lse)u:6rcehaCnogheoirntpoufltmalocnmairnyefrusnacntidonmbilylesrms (o1k9in75g aanndd TPYCaaue0T<>06TTc20Tl<5S3<31111arck-0o-2oo26-o2r-50rI229618es-tytt--t-00y50a8aa-a6-5n221e82ee-l-lll-0-t93a721am412rer28-sspx2--4l6p2ooyseudre No A FEV A FVC 12322015343 00000-000002496727266 00000-000008810524572 1322011620233 -000000010100061056339929 -00O00000000lO371551O1752 13301159372 00000000105473634062 00000000009227540062 14201124389 00000--000006268643226 0O000--00l00l4525O2162 awnads t1h-e8 gmeogm/me3troifc rmeespainraebxlpeodsuurset. for the population Discussion eseEbtAatcoshaeufhxnvexfflcirpTeeecatesptesernolcihostyyorstuesatsssenurouiguaaarsamrmgdrgeildtensoegjaeeiusfopdeldggtctssgsoiiroirvtatomurroioweannantmuudtriopag,aopipoksahlbnacffcnesusboawurcntoursw(asmeaifsfta.nrhos1ccudee0tcciitalhgli"ehliaud1eyeaaiit3ssaestroisTe-aservem8wfhdsrhetoctstoaoaeuofe.twswdksandTobuilsifynrbncthimsaeehorstgsnusmattoytusrsrlowkeseaelmuesattiifavtgchsnfriasectneoaesglilocnlonivnfantdfeatfioownchsoctipaipner.nctassnahuuuitslcettteatlmi.hlwmhinclateaeutEioccoee)lk-rnxxashhwwiopapthniiisegogartooagsdhnhhyys. 238 esswstegb(hmhuiffregiffrrooteneeheepuuccdisrfpltthfiidessoacthvhharnonoebinafoslntedtdnhtttehiiealwnrlsdeedifeemvotg.mi-eernreiyrlktovaceeuvagaaiodgalnpruffalisuutaowr)ulteneelaedttxlwsdhtywepeihaoosraisibesrfmcuspkoqhutrouiouhngeirktaseggteree1grtcdlps-ersio5tfureusheialnm.lemotdtrefthSgoehrai/animnbittsnahcew3rsteaa.thyonusEmretsdhkf5oxeuyecicpdnmuniaosiagrccrtgsrttuaeu/iilemoloidrntlfnnyoyeet3 cteppwgUtwepsbhoomxxrroleoanoerepTpoEpfrsofaryosoou3khoofketpersfs-vrleeenledeeuuea0atrreroccutrrtsrcastittet(eenaosonih8m-avlanawnnr-aalaterot5g.cenusfireent/lttlspaalmhuaheoeyylnortdilcx,e3cpseorgiil)pauadsutaneotlirirehtelgsonrsmroecmvseneg)eedtfte.folneahialffeonndtypeoeLtxwofa.criullpovlefrFetitTlotonebshvymeEhwlhisgeeexysuoVwile-fpsssnuurlrns,iiotteaotnhlpfouosohserffaocudosotyentwreiisyrlifnmtsxd,loefiuotfptens.nhaeuehcwucoaFrvohnitgrsv-neVwicouurgnarotroCaeetrpalifhwvosegnitticnesessisosaturmseonls,trtysceahta-orhdtendutsaleoaaoemlodnltnsrrcadieyitstonstrsdenthka(retuauto0nteeebaamndhss-nroctlltd2yeeeecstt. References '1*'**DHKMKKrolilatoAIepeteBL11wginniieltls9ru9unnidhnasosn3ne6ffutseoMg5eeog4eBsrcllWGr;tn;eddMi,rSy9addeiLWD0:fatuMDofM5iuJ,l:suoer51n.Ct,gM.nnaHi39c1Bn,Misc1tMa-9yoaygteiD6--gi5oelcofle64Ji4ascnehtensIBas.3l;otnsnliilt.Aa.imtiicede:etnieTuOnV1pFatJsma4oa.San,Jtlr6lu,licdT.ctKlli0naleaoAaSps-loTdllsc1JnhcosioMMs.aesaypxtnupiuomei.nwndmicddferTaooyoiuotlnchlrhummocoakeneJgoOlief,ogneynrOwr..cfesKiufooS.sDf1oebof.nshi9cribiociksatAs4oPeesyep9Csrrrunirioincs;srbhs.3fhaio.elnte11niehsTdcxJ:9xte3.rupO6pEa5s1HoPto0nnt,e99surs;evsxe-y61uSlaai6dtm.04rrliwc4tloe;:Jtheot.84ienooont65noiunatnR:-darsr59ddcHenly93cuoukpae2s.svoiflaatt-terrnl8hoRttiyndsnhe.f.. Wegman, Peters, Boundy, Smith 1,"11"17"1""7`*10117154.775KMKFGJJHVCKBFBFMWKaailleeaioaenaiacctrepdenPtJrgGsPDluasODVaR11lrfsDL1Heerrtthm11rr1onuuoooeedilimiiunupurercrspnaxirea99n9enee99ooea9nneusfiIebciibesoekydsepuibdrrsraedssrpcf6s7fnfo7nponns78prrdacs7Lcststukutsmieeltscpekomih56iCtlRdk6ciCu19yrreealA6ABJoaBJrpBbmllcsotrirtE-eEamioa;e;Widd;rpaar;F,;enh;rao,uSnoeig1n,G3,a3WMaG18ttps1orJLfCanoCtosnaMtolonmseninmoMhgs013BFoPDM7:Maap1nT,gtRc,fshft,e.r1qftr.2eetdi,ir::i:otpr:.e1troheG3edenyroCoiiaer4G12sfF9eydJuc70,tTsyPDiTtsralstSeena9onPo:alid,eccnF,hK39l1,6a,e71he5harMtudnaionrlo7tttird,heetDSanmrrse1751nc7ca1co5e-teol8iltem1ildGwt3tsimSriDltc1seltnlMdec-ho--9n;tz9s-smeru7ofeoR9loaeGtVee;1w722oosr92eeeiloi-nat7raieo7rai6s-ntJn1rasmonotsu,le4H9.s0naeuario2i.nYCl6eldxt9bMfooln7G:.isinSn4wwsdcpKist:o.0t1tvrgc.p0uir,;EieJnd;rrs3ihA.ea,Ae:Ande3ank.1aon3-,eeyM.io2s0sRoa.cP0WnKvotCCein6emStVsrtn1tn2JmS.s3ikI.ehtpiChtI4uuCBtordTlr,rId,y:nu,,,5hd-hOn,2oaA,aeaoees:b1ld-liT4Jou,hLr:ee:JlmuexlnW8.-grMlLBo2yIiFM,cvDl7melPsT3rmB,ltoe8mLnnm,uspag.iAaceug.yrs7LE6UMoSs.aah.1oeiiRnneeoenarulASetmno-mnterm9ndetVLhceHg.ilbIrdgBsgnstrse3upsehec,bynomnoligm-etam,ueoecesiee!iirar.4ddhiboi7inMtntrdpnglnnorwRrrroo.eePet.ba1tla6efnMJw.eedic,iRWoomEJlnMpduAPe1nruuoanveHi9.:soouaMJtouixKoevNI9nxr,xprrtnoeB1tzg,nBrmMlASEniyRiapcvhts7DcQvnaPirs.q4yJee-wuRPgithrdtB1MahtM,t,,aeeltt,awR,a.un:faaHiatlAuisrueyo3.sooriul;ltABeDlslbSrr,eMADDcsm5eabBdbiJoE,ar8nrnoiueesltpsHRwsTak,ondg0lteaeeEfy2,a,.axiurpeeFisof:isdeBnAmeeslj:eosLnpraed-r:oituBier3ByVrwtepshgarpu4gabnmnotdemyAiHcsrtresi9reauVoDinferreied2alersd.noDt1nndiroaelaP5tpcrrasr.elJsduy9lARcirTWcdac9tcrstnsePirmrliasdUss,-nCkor.otkles,himo.mr7:o4AihpmscmiehSJc1-efoAtwichRnnW3I1M.o0yfaisoeay1r9ctoi.nhrnarioDsBc;.eh9ossRltes2w9htse7oEJtPVn3locfA.S.driaviie7tla.r.o7..T.osE3tnBob,o0uourlnoIVeurye9PL.w,c6us;n1piNAihflE:gnt.vrsErTe3;c1dAm2fria;JtJkt9oaie1vm-iTtFDkfrfo1eo4i9.inRirwcc5urJn6oetfsnfni1mtool1nc7oih:vhtrceedbyoe-ptlrob7re2tS9wunesf39uiEono3Ieochmsoyhsen.JVrnlfr-t9:entera.td:inpwvn4oputl1,7oouteenA-s4dmfr8deeEeiIyRietri.sdn9xu4fOdy.n-iJ7HrnH.rrd-kmoenpaRnuaypme7si.1mmfE3o5etrexcSeevSfeergyppeof-3iMT0mf-eatrnapaiisouodtetieass5o.tJsRrsm8.saanDr5nalalvuftpnanMefienor3tteBhto2eNtollootihliahriitcaddeitAccedna.d.pnvcefr.ssr..fl..fl