Document vBj1Dy180m3RqjbdJweKQk1k6

ATTENDEES JANUARY 17, 1973 CM Sub'jec-t to - -' ROSS ,, co~ J -- Calcas^-1 MANUFACTURING CHEMISTS ASSOCIATION DR. MAC ROY GASQUE, MEDICAL DIRECTOR OLIN CORPORATION DR. RICHARD KOCIBA, PATHOLOGIST THE DOW CHEMICAL COMPANY DR. THEODORE TORKELSON, TOXICOLOGIST THE DOW CHEMICAL COMPANY ICI, ENGLAND MR. DON ELLIOTT, GENERAL MANAGER - PRODUCTION SOLVENTS AND MONOMERS GROUP DR. DAVID DUFFIELD, MEDICAL DEPARTMENT MONTEDISON, ITALY DR. TIZIANO GARLANDA, PROTEZIONE AMBIENTALE E SICUREZZA MILANO PROF. DOTX EMILIO BARTALINI, HEAD OF MEDICAL SECTION MILANO SOLVAY et Cie DR. MARCEL-JEAN LEFEVRE, TOXICOLOGICAL OFFICER BRUSSELS MR. AUGUSTE GOSSELIN, INGENIEUR E.E.G. ' BRUSSELS RHONE-PROGIL DR. JEAN BERROD, MEDICAL CHIEF PARIS UNIVERSITY OF BOLOGNA / PROF. CESARE MALTONI, INSTITUTO Di ANCOLOGIA CONFIDENTIAL CWA 008547 CONCLUSIONS FROM EUROPEAN INFORMATION ANIMAL STUDIES - WELL DONE; LITTLE REASON TO DOUBT - POSITIVE AT 250 PPM AFTER 82 WEEKS - NEGATIVE AT 50 PPM AFTER 82 WEEKS - HAVE ADDED MORE ANIMALS * PRELIMINARY HUMAN - QUESTIONABLE SPUTUM - QUESTIONABLE EAR (SKIN) - WILL DO EPIDEMIOLOGY BY COMPANY USING A COMMON QUESTIONAIRE RELATIONS TO U. S. & MCA - EXCELLENT; CONTACTS ESTABLISHED - WOULD LIKE TO SIT IN WITH MCA RESEARCH COORDINATORS - WISH TO MEET BEFORE OCTOBER 1974 - WOULD NOT LIKE CONVERSATIONS BETOKEN INDUSTRIAL BIO-TEST AND EUROPE OR MALTONI AND U. S. ^UNLESS THEY WERE PRESENT) - WOULD LIKE TO HAVE U.S. CO-SPONSOR ITALIAN WORK / CONFIDENTIAL CMA 008548 OPTIONS OPEN TO MCA I. CONTINUE PRESENT PLAN WITH RATS AND MICE 5000 PPM 500 PPM 50 PPM I 2. LOWER CONCENTRATIONS AND ADD HAMSTERS 500 PPM - SMALL GROUPS 250 PPM - FULL STUDY 125 PPM - FULL STUDY 50 PPM - FULL STUDY \\> 3* .0* rO' a. U.S. ONLY b. U.S. & EUROPE c. EUROPE ONLY Zfl- 3. SCRAP ANIMALS AND DO ONLY HUMAN STUDIES 4. METABOLIC STUDIES 5. SORBTION & REACTION STUDIES WITH FEED AND BEDDING 6. CYTOGENTC .STUDIES 7. TERATOLOGICAL STUDIES CMA 008S49 CONFIDENTIAL