Document v6pdn64eqwK7VBnkwgQw4D6dR

AR226-3383 HASKELL LABORATORY Common Name: Telomer B Carbamate Cbpimiral Name: Reaction product of hexamethylene diisocyanate biuret with alpha-fluorogamma-hydroxyethyl-poly(difhoromethylene) and 3-chloro-1,2-propanediol (37.7% aqueous dispersion) CAS Registry No.: None Chemical Structure: oh ho HI I It IR f - C - N - ( C H , ) , - N - C 26 H OIII N - (CH ,).-N -C -R I 26 Rf - C - N - (CH- ) -- N - C Il I OH 2 6 I II HO where Rf = C F 3 ~ (CF2)x~- C H 2~ C H 2-- 0-, X = 5, 7, 9, or 11, and R = Rf or Cl - CH2-- CH (OH>- C H 2 " O- Phvsical Properties: Form: Molecular Weight: Boiling Point: Melting Point: Density: Milky dispersion 1570 to 1760 1.17 g/mL Recommended AEL 1 mg/m3(8-hour TWA), respirable particulate General Toxicity Telomer B Carbamate has very low acute oral toxicity with an ALD in the rat of 25 grams/kg (DuPont, 1983d, 1983e). When applied to rabbit skin, slight irritation occurred (DuPont, 1983b, 1983c). Instillation into the rabbit eye produced mild to moderate conjunctival irritation (DuPont, 1983a). By the acute inhalation route of exposure, Telomer B Carbamate has a 4-hour ALC in the rat of 76-80 mg/m (DuPont, 1986a, 1986b, 1986c). In a ten-day subchronic study, groups of rats were exposed six hours a day to 5.2,22 or 58 mg/m3. No adverse effects occurred in any group (DuPont, 1986d). Basis for AEL The relationship of Telomer B Carbamate and Telomer B Citrate Urethane (TBCU) was also considered. In a similar ten-day subchronic study, TBCU had a NOEL of 2.5 mg/m3 (DuPont, 1984). Based on this NOEL, an AEL of 0.1 mg/m' (8-hour TWA) was recommended for TBCU A similar safety factor was applied to the NOEL of 58 mg/m3 for Telomer B Carbamate and an AEL of 1 mg/m3(8-hour TWA), respirable particulate recommended. Telomer B Carbamate was updated in 1990,1995 and again in 2000. No additional information was found. References DuPont Co., Haskell Laboratory Data: 1983a. MR-4975-1, HL-422-83. 1983b. MR-4975-1, HL-472-83. 1983c. MR-4975-1, HL-473-83. 1983d. MR-4975-1, HL-488-83. 1983e. MR-4975-1, HL-489-83. 1984. MR-4932-1, HL-143-84. 1986a. MR-7272-l,HL-2-86 1986b. MR-7272-1, HL-11-86 1986c. MR-7272-1, HL-22-86. 1986d. MR-7344-1, HL-230-86. Richard C. Graham October 23,1985 Updated by: J. C. Cook January 31,1991 R. R. Montgomery January 29,1996 S. L. Cattie November 28,2000 p:\word\aeldocs\telomer b carbamate 2- -