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11434 Federal Register / Vol. 59. No. 47 / Thursday. March 10. 1994 / Notices DEPARTMENT OF HEALTH AND st any time to conduct research to fill of setenos. including risk assessment of HUMAN SERVICES identified data needs, until ATSDR chemicals, thus creating a scientific base Agency lor Toxic Substencee and DMene Registry announces that research has been initiated for a specific data need. inMIftSf amrtnr far filling a breeder range of data needs CERCXA. te section 104UX3XD* ,, stetea that R is the sense of Canmn [ATSOR-79] Statue ot the Superfund SubstaneeSpeeffie Applied neeeerch Program interested in volunteering to conduct* this type of research may write to Dr. William Cibulas, Chief. Research Implementation Brandi, Division of that the cotes for conducting tab research program be bosns by thn MitMhwM and p r. in otilf hazardous substtnese under the Tates AGENCY: Agency far Toxic Substances and Disease Registry (ATSDR}, Public Health Service (PHSL Department of Health and Human Services (HHS). Acnon: Notice. summary: This notice provides the status of ATSDR's effort to fanpUmoi* the Agency's Substance-Spedfie Applied Research Program (SSARP). This research program, authcrtasd by the Comprehensive Environmental Response, Compensation, and liability Act (CTtCLA), aa amandad by the Suwrfunrt Am*pMwR*t awiI Reautharization Act (SARA) (42 U.S.C 9804 (i)}. we* laltiatad on October 17, 1991. At that time, a hat of priority data seeds far 38 priority hazardous subotancaawss announced in the Federal Register (54 FR 52178). The list was subsequently revised besed on phH/ wBUMBti, mil published in Toxicology. Agency far Toxic Substances andDisaase Registry, Suhstenons Control Act (TSCA) and by mgiatxanta under the Pedate MailstopE-29.1600 Clifton Road. NE*. Atlanta, Georgia 30333. FOR FURTHOIM70RMATKM CONTACT: OK. William Gbulas, Chief. Research Implementation Branch. Division of Toxicology, Agency far Toxin . Substances and Diaaaaa Registry. Meilstop E-2S,1600 Qifton Road. NE.. Atlanta. Georgia 30333, telephone (404) 839-4308. Insecticide. Fungirtafa. and Rodnatidde Act (PIFRAL ar by cote recovery front peitiea nA.rCTCI A aSad this statutory intent, ATSDR aisveloped a plan whereby ports of the SSARP will be conducted via regulatory mechanisms (TSCA/FIFRA). private actor voluntarism, and the dired use of CERCLA funds. A Tri-Agency Superfund Applied Itsssarr.h.Committee (TASARC) SUmSMOCTARY MFOMMTKM; comprised of scientists faun ATSDR, NIP. and tha EPA has bean set up to: The Comprehensive Environmental. Response. Compensation, and Liability (1) Advise on the assignment of prioritlae on mechanisme for filling date needs; (2) coordinate knowledge of Act of 1980 (Supotfand) or GERCLA. aa ressarcb activities to avoid duplication amended by the Superfund ' of research in other programs and under AjMendmente end --iitWfaaHflq Am other authorities; (3) advise on Issues of (SARA) [42 U.S.C. 9804(1)). requires that science related to substance-specific ATSDR (1) faintly with the data needs; and (4) maintain a Envircnasrotal Protection Agency scheduled forum that provides an final farm on Novambor IS, 1992 (57 FR 54150). The 38 snhetennpa. each of which Is found on ATSDR's list ofPriority Hazardous Substances'*' (56 FR 52188. October 17,1991). are iildrtn/dfeldrtn, arsenic, benzene, beryllium, cadmium, (EPA). develop and prioritize a fiat of hazardous substances found at National Priorities List (NPL) sites, (2) prepare toxicological pscJUee far these subatencas. ate Pleasure the initiation oft research program to fill identified date needs assortsted with the overall review of the ATSDR SSARP. Tba TASARC has met four times since tha initiation of the SSARP. This notice provides the status of ATSDR's efforts to onpfamant the SSARP. focussing on ongoing activities relevant to test rule development under TSCA/FIFRA. carbon tstrachfori(fa. chfaroethsna. chloroform, chromium, cyanide, p,p*DDT.DDEJ3DD. di(2- wbteaaoae.Jfafara starting enefc e private sector voluntarism, and direct program. ATSDR will consider urn of CEROA funds. Additional date mmibi.ii list ns nftle ls>nny * needs are being addressed through an ethyIhexyl)phthalato. lead, marcury, Testing Committee established andtar interagency agreement with NTP, by methylene chloride, nickel, section afe) of the Toxic Substencee ATSDR's Great Lakes human health polychlorinated biphenyl compounds Control Act cm the type of research that effects reaearch program, and other (PCSs), polycyclic aromatic should be dona. __ ' . Agency programs. To date. 99 priority hydrocarbons (PAHs) (indudas IS ^ On October 17.1901, ATSDR date needs associated with 35 ATSDR substancaa), selenium, announced the tofanrtfleatloo otthe priority hazardous substancaa tetrachkroetbykne, tohranau priority data naetfa far 38 priority - - (infhiding is PAHs) are being hazardous subamncaa (58 FR 52178). eddmesea via these mechanisms (Table This nodoe alao sarvoa aa continuous call far vohmtary waaaich initiatives. ATSDR anooumgaa private ectcr organizations to volunteer to * conduct research to fill speclEc priority data needs. A Td-Agsncy Supernmd Applied Research Cncmrittee (TASARC) comprised of scientists horn ATSDR. the National Toxicology Program (NTP). and tha Environmental Protection t research afiosta. DAT8S: ATSDR constdara tha vohmtary research effort to be important to the continuing development oftil* SSARP. Thasefase, the Agmcy encourages private sector organizations tovolunteer private i to conduct r march to fill spadfic priority data needs. On Novambor 18. 1992. the Agency published a revised list of 117 priority data needs far than priority hazardous suhstancoa (57 FR 54150). _____ _ Tha mafar goals of tha ATSDR SSARP are: (l) To fill the subetance-roacifie information needs of tha public and idsntlflc community, ano-(2)tn sigplj information nacaaaary to mnrhirt - comprehensive public health iiMiiamtnti of populations faringnear hazardous waste ritaa. This pragmas also will pcovida dote that cm be generalized to otbsr substances or a 1). A TSCA/FIFRA In developing and implementing the SSARP. ATSDR. NTP. and EPA have established procedures to identify priority date needs of mutual Interest to Federal programs. These data needs will ba filled through a program of toxicological testing under TSCA. This portion of tba research will ba conducted according to established TSCA procedures and guidelines. This testing will falfill more than one Feden program's need. During FY1993. a Abate of the 117 priority date needs fa 38 substancaa (about 60) was ratened ti the EPA under its authorities following BFG407i0 BFG 00205 b h Federal Register f VoL 59. No. 47 / Thursday. March to. 1994 / Notices 11435 review end endorsement by the Currently, ATSDR la pursuing minority citizens. The purposes of the TASARC oversight committee. voluntary research Interests with two ATSDR-MHPF cooperative agreement 'unently. 28 priority date needs private sector organizations: the General ere: (1) To initiate research to fill uodated with 11ATSDR substances Electric Company (GE) and the ATSDR-identified date needs for have been recommended by EPA to be Halogenatad Solvents Industry Alliance priority hazardous substances, and (2) to added to ita Master Testinglist, the fiat (HSIA). To data, through the voluntary ntw evisHeg disciplinary capacities step in test rule development under research efforts of GE and HSIA. four to conduct research in environmental TSCA, tection 4 (Table 2). Please note priority data naeds for two substances health at MHPF member institutions. that although ATSDR has identified are under discusafon. potentially The areas of reaesrch st MHPF priority data needs for oral exposure to leading to the signing of two institutions include those related to tetrachloroethylene. cyanide, and memorandums of understanding (Table broad areas of toxicology and beryllium, in response to otherFederal 3). environmental health science. Some of government agency needs. ATSDR will consider proposals to conduct During FY1993, ATSDR staff members mat with officials bom (X to the MHPF member institutions are mwdmUwg health studies of minority inhalation studies in conjunction with discuss the Agency's research agenda ooupe exposed to ATSDR's priority pharmacokinetic studies for these for PCBe. The Agency has identified hazardous substances. substances in lieu of bioassays using oral exposures. It is anticipated that mutual interests in environmental fata testing and human health endpoints D. National ToxicologyProgram inhalation data derived bom these assessments and has initiated ATSDR maintains an interagency i studies csn be used, in conjunction with pharmacokinetic modeling, to address ATSDR's orel toxicity data needs. Some of ATSDR's priority hazardous substances will not be added to EPA's Master Testing liat because they do not fall within the bounds of TSCA. Section 4 authority. For example, TSCA done discussion on these studies with CE. ATSDR met with HSIA representatives to discuss the use of physiologically-baaed pharmacokinetic (PBPK) models to fill priority data needs for six volatile organic compounds. The Agency selected methylene chloride to start using PBPK modeling to eddreee ATSDR's toxicity priority data needs agreement (IAG) with NTP to conduct toxicological testing of substances identified at NPL sitae. The studies determine levels ofexposure that present e significant risk to humane of acute, subacute, and chronic health ethcU. Often these studies include an igaarment ofthe euhetance'e ability to cause cane*, reproductive toxicity, and not require testing chemicals that are because of ths extensive database on birth dafacts. Too remits of these out of production, such as PCBe. Furthermore. TSCA is not considered the appropriate mechanism for tasting this substance. The toxicity priority data studies are used by regulatory agencies needa for the remaining 5 volatile such ae the Food end Drug organic compounds (carbon Administration and the EPA various PAHs, because tha PAHs ate by tatrachlorida, chloroethane, chloroform, environmental and industrial groups, products ofmultiple industrial tetrachloroethylene. and and ATSDR to improve tha ability to processes and. therefore, it is difficult to trichloroethylene) may be addressed via conduct public health assessments at identify specific manufacturers. In similar voluntary efforts in tha faturs. NP1. sites. Under this agreement, one addition. TSCA guidelines rat not available for some of the ATSDR priority data needs such as the development of analytical methods for C CERCLA-Fuaded Research (Minority Health Professions Foundation Research Program) toxicity priority data need identified in .the SSARP (camm tetrachloride, tanmunotoxiodogy battery of teats via cadmium and beryllium, mechanistic During FY 1802. ATSDR announced s eddiesesiLThis NTPstutlywas^egun studies on the neuruUndc effects of leed. $4 million cooperative agreement in September 1993 and should be and tha mitigation of toxicity ofvinyl program with ths Minority Health computed in February 1994. chloride. Moreover, same ofthe ATSDR Prohetiona Foundation (MHPF) to priority hazardous auhetencee ere support subatanos-apecific ' B. CroatLakm Human Health Effects considered more appropriate for FIFRA investigations. This cooperative venture Research Program than TSCA, e.g.. arsenic, DDT, and is supported bythe direct use of Scow ofthe priority date needs aldrin/dieldrin. The Office ofPollution, CERCLA binds. During FY 1993, shout identified in the SSARP have been Prevention and Toxics (OPFT). EPA. 54 mtltiwi was allocated to continue Independently identified as research forwarded the data needs for theaa this research program; no new projects needs through the ATSDR Great Lakes substances to tha Office ofPesticide wen initiated. Currently, 9 priority data human health efforts research program, Programs for evaluation. needs for 21 priority hazardous a separate research nrogmm. To date. 12 B. Private Sector Voluntarism substances (including IS PAHs) in the SSARP are being addressed by the priority data needs tor 19 priority hazardous (including is ; As port oftbaSSARP, ATSDR MHPF institutions through this PAHs) identified in the SSARP are being initially announced a sat of propoaed program. Also, the MHPF research addressed through this program. The procedures for conducting voluntary program will address 13 othar institutions receiving awards and their research on February 7,1992 (56 FK 4788). It was revised based on pubUc sUbstanceepedfic data needa identified respective studies are listed in Table 5. in tha ATSDR toxicological profiles The Greet Lakaa Critical Programs Act comments end published on November exposures and related health of1990 mandates EPA. In ctmsuhatian 19, 1992 (97 FR 54100). This voluntary : research program fills priority data needs along with othar mechanisms such attest rule developmsnt through effects. The institutions receiving awards and thair respective rematch croiecta are listed in Table 4. *TfceMHPF. a not-for-profit 501(c)(3) with ATSDR. to prepare a report by September 30.1994, that assesses tbe advene efforts ofpollutants in ths Greet * musmRmmm M> ffa| hfUlth flf EPA and CERQA-fundad research. organization, is comprised of 11 individuals in the Greet Lakes states. A Privata sactor otganiatlnns were I tovohmtaerrto conduct miarcbto fillthese specific priority minority health professions schools. Its primary mission is to research the persistent health problems that variety ofperristent toodc substances are prevalent in theGraal Lakes. including Rat. DOT and Us metabolites, diridrin. datanosds. disproportionately plague poor and tnxaphene, mlrex. mercury. BFG40711 BFG 00206 11438 Federal Register / VoL 59, No. 47 / Thursday, March 10, 1994 / Notices benzoWpyrene, hexachlatobenzeae, priority data need for 37 of the 39 consumer products, or occupation can furens, dioxins, and lead. Certain priority substances (Table 1). ATSDR be used to design a rigorous analytic populations--Native Americans, sport will obtain this information through epidemiologic investigation. anglers, fetuses and nursing infants of exposure and health effects studies, and Epidemiologic studies on several of mothers who consume contaminated through establishing and using ATSDR's 38 priority hazardous Great Lakes fish--have a potentially substance-specific subregistries of substances (sudt as DDT, PCBs. and higher risk of long-term advene effects people within the Agency's National PAHs) are being conducted by the resulting from exposure to these Exposure Registry who hive potentially ATSDR Great Lake* human health contaminants. been exposed to these substances. effects research program (Table S). The ATSDR-supported research The list af 36 priority hazardoug Two epidemiologic studies on lead projects focus on these high-risk substances in the SSARP was forwarded (identified as e data need by ATSDR). populations to try to further define the to ATSDR'* Exposure and Disease human health consequences ofexposure Registry Branch (EDRB1, Division of am also being conducted by the Morehouse School of Medicine end the to these persistently toxic substances. Health Studies, for consideration as King/Drew Medical Center of the The research activities include, but an potential candidates for fubregUtries of Charles R. Drew University of Medicine not limited to: (1) Characterizing exposed parsons, based on criteria and Science via the ATSDR--MHPF exposure determining tbs profiles and levels ofGreat Lakes mntemtp^ described in SORB'S 1988 document. "Polidaa and Procedures for cooperative agreement ATSDR expects that other substaace-spedfic in biological tissues and fluids in high* Establishing a National Registry of epidemiologic studies, identified as data risk populations; (2) identifying Persons Exposed to Hazardous neads or priority data needs in the sensitive and specific human Substances," To date, ATSDR has SSARP, may potentially be conducted reproductive/developmental end points selected benzene, chromium, and by other Divisions within ATSDR. and correlating them to exposure to Great Lakes contaminants; (3) determining the abort- and long-term riskfs) of advene health effects in progeny whoso parents wen exposed to Gnat Lakes contaminants; (4) Investigating the feasibility of establishing registries and surveillance cohorts in the Great Lakes region; and (5) eetahHahing a chemical mixtures database with emphasis an tissue and blood levels in order to identify new cohorts, conduct surreillaiice and health effects studies, and establish registries and surveillance cohorts. During FY1992, ATSDK announced a 52 million grant program to conduct research on the import on human health of contaminated fish consumption in trichloroethylene as primary contaminants to establish subregistrias in the National Exposure Registry. However, aldrin/dieidrin, carbon tetrachloride, chloroethaaa. dtlorofoim. cyanide, p.p'-DDT, DDE. ODD. di (2ethylhaxyl) nhthalate. mercury, methylene chloride, PAHs, aeVenhim, tetrachloroetbykna, and vtayfcafctarii| remain as a part ofthe rantHuma poof They will be considered for selection as primary contaminants during each selection process (Table 1). Finally, arsenic, beryllium, cadmium, lean, nickel. PCTa, toluene, and zinc an not considered to be in the pool of candidate substances for an exposure registry at this time- This decision will ATSDR acknowledges that the conduct of epidemiologic studies to determine possible linkages between exposure to hazardous substances and human health effects may be accomplished other than by Agency programs, or under other ATSDRspanaotad auspices. Toward that end, thp Agency encourages the private sector end other government programs to use ATSDR's priority data needs to plan research activities to identify appropriate populations and conduct studies addressing the specific human health issues. Finally, the collection, evaluation, and interpretation of data from mmimiiImuiI around hazardous the Gnat Lakes region. OB September be re-eveluatsd as more infonnation on waste sitss have bean identified as 30.1992, ATSDR nine awards under this nromm. the chemicals and exposure sites . becoms available. priority date needs far all 38 priority hazardous aubstancea by ATSDR. InFY 1993, aboittilnSioB was With regard to epidemiologic studies However, the Agency realizes that a lot allocated to support the continuation of ATSDR believes that for many of the 38 ofinformation has already been the research projects conducted at the priority hazardous substances, an collected through individual state nine institutions originally funded extensive amount of animal data, and programs tod the EPA's CERCLA during FY 1992. In addition, ATSDR some human data, have already bean activities: therefore. ATSDR will awarded one now grant to the Michigan collected; therefore. ATSDR ccnsidara tt evaluate dm extant infonnation from Department ofPublic Healthto deeim. appropriate, where feasible, to conduct theea programs in order to help fill data establish, and operate a professionally epidemiologic studies on sudt needs on substance-specific exposures. creditable intaruboretary quality aisurance/quallty control program far the ATSDR Gnat Lakes human health effects research program. F. Other ATSDR Pngmm In its role tea public health agency ftddnniBg h-- ATSDR may, when appropriate, collect human data to validate annetanoe- substances. In response to public comments, the Agency's SSARP will address substance sparifie rathat then site-specific epidemiologic studies. The substance-specificstudies are tfariqwA tn <hnmhe mhetarae. specific cense and affect. In this case, ATSDR is not necessarily dfrectad toward populations exposed via the environment at hazardous substance The results of the research conducted via the SSARP will be used for public health saesstmants and torsas*see ATSDR'* substance specific priority data needs. The Agency expects to re evaluate tbs priority data needs for priority hazardoue substancss svery three yean. Dated: Mncb 1,1894. release sites, as in a site-specific study. WatarB.Dewdh> information on levels of contaminant* in humans has bean identified as a Instead, any sppropriate population of DeputyAdministrator. Agency/br Taade suitable exposure via the environment. Substancss andPfseose Repttry. BFG40712 BFG 00207 Federal Ragtato / y0i. 59. No. 47 / Thursday. March 10. 1994 / Notices 11437 Table 1.-Substance-Specific Priority Data needs Currently being Addressed Under ATSDFTs applied Research programs Substance y Arsenic Priority Data Need Addressed 1A Marhenirtc rtxles on tie narxotaxic sheets ot teed IB Analytical methods ior tleaue levele 1C Exposure tovela in humane flying near hazardous wasta eitas and odwr populations, such a* exposed workars. 2A Comparative toxacoMneSc Hides to determine I an appropriate animal spades can be Mercury 2B HalMivee in surface water, groundwater---------------------------------------------------------------- 2C BtoavaUabilty tram seS __________--_________ __________________________________ 2D Exposure levels in humane Kina near hazardous waste sitae and other populations, such Aft txpMid woricsfie 3A Mdgenareltanrepraduetiue toddy atixly via oral exposure________ 3B Ooaa naponae data In arlmais tor chrotvo-duation oral wmoetxa ___ 3C Itnmunosoucotogy battery at taste wa oral exposure - 3D Exposuta levels to humane flvtaQ near hazardous waste arias and other popMattona. such Viny! CMortde. Benzene 3E Potofdal eanddate tar subreplaSry ot er^oead persona " 4A 4B 2 4C 4D 46 4F __ aasapaaedwed--l , ^ 4 4G Potontaloanddato tor sutao^siryot exposed panona . .......... ....... 5A fines reepnnaa daaa in artraato tor ante and jrSawreilata itisdiiii oral exposure. The aubdaerde study shod* Indude an etosndsd raproducKeorgan Naiopathotogy. SB 2-apedsedevetopmantd toddy study via oral aepoaur*__ SC HiirnSiiiSiAijj iiatlatj it torts ~H r~al nprrrt - 50 epomoiogai ruoii on uv wwi mni o* Dvomi i^piqb tn\pnM nponi - dudorburaunototoc^r^ 86 Bmmm ln^re fleevi Iemwmnmm fi^t^yreelmsse Ms^^^awsr Ietf^atrieai^Hriai^wa^sipK^P mOi ireAau^mp^p ^Mpwlr aM^^eflsd^^ds a^apu^ups^^u^a^e^are ^^aM^e^ekv Cadmium SA SB fluids and atwbonmantol > sltoa and other poputaflona. such PCBS 7A OoMn^onidtfihwiRMli tor rate- vtfintoniviflrtHkiilonQfikixpoMil ........... 7B Btodoqradaton al PCS* m water Wowtetehlty ot PC8i to tor, water ond ol -............... 7C OMKdMMMi iMi b Mbnit tar | MMMiMMlnfln finMOkn aamine^rep^fl^^^^^^Pdrevtiriwi^^^F ^^vtsan^Bs^e usa^eas^^^ mMax re^s^^essi^pare^HB^^^a^BUP^H^H^si rere^^re^Ki^a^os ^w^^p^a^^^aOT^^^pe in mbbiqk raoy mom vnnv vnMioiorabWGnf 7D gpMsmtdogfcal Hudee or the hedflr eriaett of PCSs (Special emphasis endpoints hduds: liliBBWBa^rt QMRVMVOi sHMyi Pni raBnb^ w^OO VRwR|i la^wWMne^O^P opmanlat toetdlyL 76 ERxoawe lavato In humane King near hazardous waala aflaa aid other poputaflona, such Chlorolotm BA owlhaJwalftatoctodctaototcrm(apacyamphaatoendpolntoln- neuratoddty,. reproductive and davatopmantof toxicity, hapdctiwtly. and ac rend toddyX exposure texeto to humane King near hazardous waato dree and other popidaflrra. such PAHs TTnilichnlfomniMtitny!wnt so M AC o 96 9F 9G 10A IflB toe too Potwxtot canddeto tor eubreQtotry d exposedpersona ...... ......... ............ ............... fTnaa naapnnas itone n adnata tor mrannarlata rtaaflntr mal aipnaim The siduTmntr atody ahetfld Indude extended rapreduetlva organ htatopathotogyand totmunepatootogy. BapeciaadavaiapmanBltoxfcflrabidyxtoWtolafloworctataRtofltw ----------------------MetfurtiUfc dudtasotr PAHs. on how mbttosaof PAHS can Influence toe utomata activa flon at PAHa, and on how PAHa ailed rapfcly prdtarating tisanes. Doee-reapenae data to anbnato tor acute- and tatornedtato-dMIan inhatobon eremeurea. Theattochronto etody should Inctuda extended reproductive orgac htotcpethnthfly and Epjttoiejtotftattojtoe on toe hadto eftafls of PAHS (Speed amphasU andpolrfla Indude: GwoHy OOfliUBp nnwjRi^ORi BnO I^^Kyr Exposure levala In humane Nno near hazardous mala dtoa and otoar pcptddtana, such via the araf nxat. o teals vis toe and rauto Cptow'-vg < studtos on ths hsaltt dtods or tocNcraailiytans (Spaed antflxdhta toduda; cancer, hapatotoxfcfly, renal toddy, ttoMtopraarflal to natadodefly). BFG40713 BFG - 00208 11438 Federal Register / VoL 59. No. 47 / Thursday, March 10, 1994 / Notices Table i .-Substance-Specific Priority Data Needs Currently Being Adoressed Under ATSDFfs applied Research Programs--Continued Substance DDT ... Chromium...... ........ Tstnchtoroettiyiene Atdrin/DMdrin . Cyanide 10 10E HA 11B 11C 110 HE 11F 12A 12B 12C 120 12E 13A 138 13C 130 13E 13F 14A 148 14C 140 ISA Carbon Tetrachloride BsryBum Toluene 158 ISC ISO 158 ISA 168 ISC 160 168 17A 1TB 17C 170 17E 17F 1BA Priority Data Need Addressed Exposure levels In humans Wing near hazardous easts sites and other poputabons. such as exposed anthem Close retponsa data In animals lor chronic-duralion otsl exposure------------------------------ _ ComparsSva kuoooionetic study (across routoaftpedas)............................................. . -- Bloevailabaty and bioaocumulailon fcom sol Epademotogicai studies on Ihe health effects ot DOT, OOP and DDE (Special emphasis endpoints sidudec immunotujuclly, reprodudfae and dsvsioptnsmsl toxicity). Exposure levels In humane living near hazardous waste sites and other pofXJtations, such as exposed workers. Potential canddata lor subragisby ol exposed parsons Hose response data in aramd* tar acuta duration exposure to chromium (VI) and (III) via otel exposure and tor Intomtadato-duraiion expoam to chromium (VI) vie oral exposure. MuMgenerctlon reproductive toafctly study via otsl exposure to chromium pit) and (VI) -___ Immunotoxiuology battery ot tests Matting oral exposure to chromium (III) and (VI) 2-spedse developmental toxidty study vis oral axpoaus to chromkxn (111) snd (Vt)---------- Exposure levels In humans living near hazardous waste anas snd other populations, such as exposed workers. Ones response daia In animals tar acutodutHan end exposure, inckjdng neuropathology and dsmesnar, and Immuncpalhology. MWQSntflBQn ItpfQyUGM WJUCWy HIQf VI W WpOHII ................................................ . OMhfttponM dM In tnimili kjf onl wpomis indudn^ nturopathotogy snd dMumoTt ind inwunopidw!iloyy 2-tpctat divitapmirttl ttddly ttudji vto oral upom .......................-............................ fetpotura tovoli in humm Iving noor htartow mm ** olhor popiMtont, ouch m txpotod wortcara. PofeMiOfll cinddra fv lubfiQMy ol Mpoood poraooo Doio-rpoM dMi in orlnttli tor Mramodtolt-dwallon ortf npocM CK-----W-.n.iLDinRt.i.y Wwl) W0M Exposure lave* in htxiwne Wing near hazardous waste shoo and ether populations, such ot txpottd woffctra. Pratntfll cancttto lof tuboptty of txpottd ptraont nose retporwe data in arSmata lor acuta- and inlamtotlila duration exposures via Inhere son. me suxhrontc aany snoun steams sxtsnosd reprooucwrs organ ixosjparrxxugy snd evaluation ot naurattahtortoiai snd nsropslhStAd endpoints- 2-species pf|*r7p,irw>*v*r toxidly study via oral axpoaura .. Evaluation ol the anviranmantal Me of cyanide in adl Exposure levels In humans Bring near hazardous wa 1 and other poputaflons, such aa exposed workers. Potential canddcto lor subnsgialry d exposed persona Onsa response data In animals lor chronic oral exposure. The study should include ex tended reproductive organ and nanwus tissue (and demeanor) hfatopathotogy. Immunotoxioology ballsry ot toots via oral exposure .----------- ..... HaMtoinsol Exposure levels In humans living nssr hazardous wests sitae and odisr popuMtona, such _ aa exposed workers. Potsndsi canddata lor subregislry ot axpooad parsons Doss response data in arimeta lor acuta- and XSeimsdsta durstlan tahstaicn exposure*. The subchronic study should include extended reproductive organ hlstopaihoiogy. 2-spadaa davslopmantal toxidty study via WtalaMnnatoaaum ___ _ _____ __ Ersrlwnntantsl lata in art? factors sltacdng &loivatt8|t in air Mvym rntTOQs t otwTrwit tnwvfwntra Wnunutoxlcology battery oI teats tottowlngonl Expoaura levels In humans fving near hazardous waste sSsa and other populations, suclt as argnsed workers. Pose response data in animals tor acuta- and mtemsrtata itsMton oral exposures. The subchroric study should indutto an extended hMopatootogieal svakradon ot toe immune * * * 188 Comparative taxicddnetic studtoa (Ctwractartzadon of absorption, datrtoutkn, and Ion via oral axpoaura). 18C Naurotoxicoiogy battery ol teds via oral axposwa ...... ... ........................................ 180 Mcranvn 01 vnnnvHnouoKi nMiwBnf 18E EJtoosure lovals in humans Wing near hazardous waste aiaa and odier populations. such m ttpoMd wortrara. 19A Epldamidoglcsl studtoa on ihe hsabh adada ot nfckst (Special emphasis antidote tnckida: rapmrtirltva toxidty). 188 2-apetias davalopmstitsl toxicity study da Ihe ore) route 18C in antmata far acute-and totarmsdtali duration oral exposures 180 Nerxotasicology battery oltoata via oral exposes .--.-------------------------- ---- 1* of nickai trem sol. -- 18R 1 levels in humans faring near dtae and other poptMtons, such iic^oiidraiMfi ^ BfG40?i4 BFG 00209 Federal Register / VoL 59. No. 47 / Thursday, March 10. 1994 ) Notices 11439 Table i Substance-Specific Priority Data Needs Currently Being addressed Under ATSOR's appueo Research programs--Continued SubStMM ID P* mty n^>ikei 39 3C Benzene *- >8A III* ____ a&bnto*t& moult return mt*m&fq)m&Kb*gMMopaheloar. SC NetMtaMoag MNyMM*eeeratespoeuRB . - ...............---------- 10A - Ctaomum toe kHMSWMcology bsasry at tesa ts Mont mule --.................... ...... ............. 12A TTnn hi mm mu ti ------- ------------ "---------------r------- --1 risen* sepoeure. 12B ieetj.nie>wpwrtrthMtMtre^^teUeflteMMineelp.d--rtum (Hand (VQ, 12C TW1WMO1BW7IWI 1M.W 13A fin-- riyrrii (Me A Manets tv scuts damns era* aspoeue. Muffle - 138 MuMgenetMon reproduce** taafcdy sariy vie ant tec1*------------~------------------- s 130 I-- dw^a>wa--l-w^ i 8^---- . .------------- T3CAIHFRA TSCA. TSCA. TSCA. TSCA. TSCA. ` TSCA. TSCA. TSCA. TSCA. TSCA. TSCA. TSCA OnhaWtan study). TSCA (IrtaristtoA study). TSCA (InhsNBnn tfudjt). BFG40715 bfg 00210 11440 Federal HtgiitB / Vol 59. No. 47 / Thursday. March 10. 1994 / Notices Table 2.--PwoiRrrY Data needs Being Aooressed by EPA Rule Making--Continued Substance Cyanida . ID 15A 1SB Betyfcun -------------------------- ISC 17A 17B 17C 17E Toluene ISA------------------------------------------- 188 Methylene Chloride---------------- 2QA WtaOrOBuHlH IMMMM.M HWM 208 24A Priority Data Need TSCA/FIFRA Dnee reiponaa data in animals tor acuta- and toMmwdtoteduNSton expoema via av hatodon. The suhatwts study should include extended reproductive organ histopaihology and avaluatton ct naurcbehavioral and nauropathctogical endpoints 2-Spades dswitopniantol toxicity study via oral exposure .......... --.... Evaluation oi the environmental talt o< cyanida in soil ,,-------------------------------------------------------------------------- Ones raeponae data in arenaIs tor acuta- and totormsalsto duration inhalalion expo sures. The xubcnrorxc study snotid indude extended reproductive organ nRBpiinOlQ^ft 9 tf trill rtfmlnpwmrmi towirHy wm ......... .................................. - ImmunotasicoICBy battery ot teats todowtog oral exposure------------------- ---------------------------------------------- Doaa-rasponaa <tota In animata lor Intermedtdeduislion oral expos*ree. The study should indudo wi trUt^Hd htoopdhologiotf tvoluotton of tht immunt lydon. Comparative toxicoldnsttc studaa (Charectorteslion ol absorption. rtoMbudon, and exersdon da oral exposure). Class raaponaa data In aidmala tor iraamiariato duration oral exposure. The study Mould Indudo uOfriol fcwnunopodwioqy ond nounjpdhology, 2-opoctao dovotopmofdd looddly tody >Ho tho oid nodi ...................... -.................. Doss issponss dtia in sntmals tor acuta- and Internedate itaaSon oral expeewee. The tubchronic study should toduda sw svatoxion ot Sianuna and nervous system (and bahatdor. demeanor) itaauaa, tnb axtonded taptoduedvo otgsn htotopathdogy. %' * TSCA TSCA (nxv- -in->-o n siudyL TSCA. TSCA TSCA. TSCA TSCA (XTw--m*----w1-T^1W----f-i study). TSCA TSCA TSCA TSCA TSCA (EPA wtoorSy address the imrmmo system retirement of Ms Priority Data Need) Table 3.--Priority Data Needs potentially being aooresseo by voluntary Research Substance PTMe................................. o 78 7E Munyom cnonoi ............ 20A 208 Priority data need Firm Epldandotogtesl ttudias on toe health eflscte ot PC8a (Special am- pniMO mpono rauom tWnunwDiOCBy* yoiiAnnwUt vmfi MNT| Monoy. OOCnjIs fldOQUCMVOMMOpnOfMR IDwCRjiB* Ocm+mporm do in onimoli lor acute* ond irttorrwdotodundon oral exposure. The subchronic study should toeksto extended ra- pfOOUGM ofQin fwwpagwogy, nowopOTwgj mo ttenteww* ond Immunopothdogy. 2 Md-- dovdopmomd taddty otudy do tm ord route-------- ----- General Etoebto Company. General Elect* Company. IMogenMed Solvents Industry * Panes. 1 Isloginalsd Solvents industry Alienee. Subdonoo Lead Mercury Table 4.--Priority Data needs being aooressed by mhpf institutions Rrn^uurUlkyj CjSbMAa nn^fAiit8l insdUtan 1A Machardslto stodas on th* naurcsoxfc effects oMaad _ Florida A 4 M Urdvonffy. Texas Sotdham UrMndy. 1C Erasure lavale to Humana Mng near hazardous The KtogfDraw Msdtoal Cantor ol too Charles R. waste sbee end other populations, such cs exposed Draw Unhandy ol Msdfcina and Setonee. Morahousa School ol Medtotoa. SA MiragsnsraSon reproductive toxicity study toadar Tuskegee Unhandy. PAHs 88A 90 Trtcnofoodiydno 108 2-specisa developmental totocHy study via oral expo- Xavtor Unhandy. aura. Dose rsxponaa data h-anlmato tor totormaJMa dura Msherry Mtdtd CoSaga. tion oral exposures. The wtochrorVc study shoiid to- ctoda extended reproductive organ Natopafthoiogy and Immunopathology. Dose response data to animals tor acute- and meer- MMirty Mtdcte CotaQt. midtots duration Inhalation exposures. The aubehrenie stody shoidd toduda extended raproduoSva otgsn Nsxrwihnirigy end tostsstopsdwtogy. Neuretoxiootogy bedsry ot tost* vie oral expoeura -- Texas Soutoatn UtdvanKy. ta BFG40716 BFG 00211 Federal Register / Vol. 59, No. 47 / Thursday. March 10. 1994 / Notices 11441. Table 4.--Priority Data Needs being addressed by MHPF Institutions--Continued Substance ID riuiy (oSanSw avtiMA*Oai mstRidcn Toluene Zinc 1 tec 214. DoiHiipQfsi ddi In Mndi lor icuii* md inncmiddHunttn dd ddomit. Thd tubdvonic WJJr anOUP mill > MinON iWWpBIwOJBII ivdudion of did toiwvjnotoQic md nmroiogicil syd* lams. Taxes Southern Unrvers*y. Xavier University. Tuskegse Univarssy. table 5.--priority Data needs Being Addressed by the ATSDR Great lakes Human Health Effects Research Program Substance Mercury > PCS* PAHs ID 1C 3A 3D 3E TA 7E 7F BE Priority data need Instfcdon Exposure levels In hunsns Mng State Univerdty ol New York at BulWo. near hazardous waits sNsa end Stats University or New York at Oswego. other popdadona. such as ex- Mkhigan Stats University. pood wortwflfc Unhsrslly ol IMaconsin--Stmsrtar. Nseaww Yr^warti Ssmtwmsw ivmra^pKii nirsxiijvismiiwMwi unlvsrsey of nds at Chicago. Unhsrslty or HnNs at Urbane-Champaign. WWQOnMl POpMVIM OI nNmi Pw 9PsRPIi MuMganendon rspndudhe toxicity Stats Unlvstsayol New Toth at Oswego. shidy da oral amoaure. UrtvenMy ot anois at Chicago. Expoau*. levels In humans Mng Stats Urdrersky ol New York atBuHato. near hazardous waste dtas and Stats University ot New York at Oswego. other populations. such as ex easR>H aw-W V- --I^--r- *- posed workers. 1 awiiawtuoewMiieyi go^ei aireObMwsn^f^f_FA^rwaiaiwslwaa* Ncv Tone mi nm wpmonL umversky ol AMs at Chicago. umvraypiMMpuisoMKinoi^dpi WlKonam Oippinot of Hndi and 8mI SowtcMe roww cwm Oi fuoiopsvy 01 mm upmini o* nom w ow 9Vtncvi> OpONd pOfMMs Ooss-rssponse data In snimsls tor Urtvetskyol Wisconsin fliparlnr. oral exposures. Bpawwopco uqm on mo noMn enacts ol PC8e (special emphasis andpoMs tnduda: Immunctowklly. gaslrolntaitlnd tadcRy. Ivar, Hd> nRjfi UljfWO OwnRjFi tePwO^mWa davatopmantal taxkJlyV Exposure lavats in. humans Mng near hazsrdotw waste sitsa and Stats University oi New York at Bultdo. Stats UdvaraRy ol Now York at Oswego. Unhmtsty ol Wlaocnam--Superior. Untvarslty oi NMa at Chicago. University ol Mnoie at UrtaaneOwmpaign. State UnivereRyol New York at BuRslo. Stats University ol New York at Oawsgc. powdiwteHv i IWx --fW*- --O---fMtx.jf- OV nHOnH_^__WA.^p^^^iSngw^Ar' New York State Health DapidnanL UnhersRy el Mnoie at Chicago. Udveraky ol Mnoie at Urbane-Champaign. WNOonnn uopvwnovv niMi wmoo 9irnM> onthehaattt Wdoonam Department d Heaflhand Social Sorvkoe. i Indudr cancer, dermal. hamoiymphaHp. and hspaik). BP ' In humans Bring Wisconsin Department ol Hoaklt and SocW Sorvicee. DOT 110 11E IIP. odMf popiMontg wch m ir> poiidwortofi Epidemiological sturlsa on lha haalBi assets ol DOT. 000 and DOE dpNW iRpVM wnfwmWL ffr oubk mmunooooiy. rdsOQiMM and davatopmantal toakRy). Exposure lavals In humans Mng near hazardous waste dtae and oBtar poptMtana, such as ex posed worfcem. Potardd candUMa for aubragialry d> State Univordtyot Now York at BuSda State UnNarsOy ol Now York at Oswego. MOspn 9VI \X9mWKf. University ol nod at Chicago. nlH--Q-----M-----M-l ^MpInMraOl VHOT mBhWS 9ft0iwCiMal OeMiMa State Univarsky ol New York at BuNdo. State University ol New York at Oweego. MkNgan State UnNarsky. Unheraky at Mnoie at Chicago. Wisconsin Department otHaafthand SocMServtoas. irrWx--O----O-----f-lln- eMw -p___H-xV--M-- --falgOjl lMlA^mdtAivSMnt AMgkOgdBal fiifiiMa (PR Doc aa-asaa nisd B-d-aa; arB ami BFG40717 BFG . 00212