Document v6j13jGoxpb1Za1QNO7dbKQeq

ORIGINAL DOES NOT CONTAIN CBI P RfCE!VC0 n p ' i C'jlC riARH AH10: OU March 10,2011 VIA FEDERAL EXPRESS Andrea V. Malinowski Corporate Counsel DuPont Legal Wilm ington Office Buildings 1007 M a rk e t Street W ilm ington, DE 19898 302-774-6443 Tel 302-774-4812 Fax andrea.v,malinowski@usa.dupont.com E-mail Attn: TSCA Declassification Coordinator U.S. Environmental Protection Agency Office of Pollution Prevention and Toxics Document Control Office (7407M) Washington, D.C. 20460 Re: Declassification Activity - TSCA 8(e) Submission Originally Assigned 8EHQ Number: 8EHQ-06-16436 (letter dated 04.07.06) Originally Assigned Bar Code: 88060000208 CAS number: 62037-80-3 Supplemental Submission - Revised Public Copy of Submission Dear TSCA Declassification Coordinator: This submission is made in connection with the EPA 2010 CBI Declassification Challenge initiative. Please find enclosed a revised public copy o f the above-identified submission. Any information still claimed as confidential business information (CBI) in the attached report has been redacted and replaced by brackets. The originally assigned 8EHQ number has been added by the submitter to the first page of the enclosed revised public copy of the submission. Very truly yours, Andrea V. Malinowski Enclosure E.l. du Pont de Nemours and Company 6 911000 018 7 Revised Public Copy - Submitted 03.10.11 Originally Assigned 8EHQ Number: 8EHQ-06-16436 Originally Assigned Bar Code: 88060000208 April 7, 2006 Via Federal Express DuPont Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.0. Box 50 N ew ark, DE 19714-0050 Confidential Business Information Document Processing Center (Mail Code 7407M) Room 6428 Attention: 8(e) Coordinator Office of Pollution Prevention and Toxics U.S. Environmental Protection Agency, ICC Building 1201 Constitution Ave., NW Washington, D.C. 20460 Dear 8(e) Coordinator: Tetrafluoro-2- (heptafluoropropoxy)-propionic acid, ammonium salt CAS #62037-80-3 Generic Name: Perfluonnated aliphatic carboxylic acid, am monium salt This letter is to inform you of the results of a pre-1977 (1963) acute oral toxicity study that we recently became aware of on the above-referenced R&D test substance. The test substance was administered by gavage as an aqueous solution, in single doses to young adult male rats ranging from 1.5 to 17,000 mg/kg of body weight. The rats were observed for clinical signs and weighted during a 14-day observation period. At the end of the observation period, surviving rats were sacrificed, selected organs weighed and examined histologically. Rats dosed at 7,500,11,000, 12,963, and 17,000 mg/kg died within approximately 3 hour of dosing and exhibited discomfort, gasping and/or tonic convulsions prior to death. Rats dosed at 5,000, 3,400 and 2,250 mg/kg exhibited discomfort, increased water intake, inactivity and initial weight loss followed by normal weight gain. These rats had slightly enlarged livers (enlarged hepatocytes with pronounced cell membranes). In addition, slight to moderate degenerative changes in the pancreas were noted. No findings were noted in rats dosed below 2,250 mg/kg. The Approximate Lethal Dose (ALD) was 7,500 mg/kg. Under these experimental conditions, the findings described above appear to be reportable, based upon the guidance given in the EPA TSCA Section 8(e) Reporting Guide (June 1991). Substantiation of our confidentiality claim is enclosed A. Michael Kaplan, Ph.D. Director - Regulatory Affairs and Occupational Health AMK/GWJ: clp (302) 366-5260 E.I. du Pont da Nemours and Company <edEx Ship Manager - Print Your Label(s) Page 1 o f 1 From: (302)773-0071 Doris Dully E. I. du Pont de Nemours & Co. 1007 Market Street D-7096-1 Wiknington, DE 19898 Origin ID: ZWIA Fecss. Express Ship Date: 10MAR 11 ActWgt 1.0 LB CAD: 4554543/INET3130 Delivery Address Bar Code 7EPA EAST BUILDING, ROOM 6428 ____________________________________________________J11101012220225 SHIP TO: (202) 564-2818 BILL SENDER Confidential Business Inform Ctr US EPA, Office of Pollution Prevent EPA East Building, Room 6428 1201 Constitution Avenue Washington, DC 20004 R ef# Invoice # PO# Dept# FRI -11 MAR A1 PRIORITY OVERNIGHT [)> 01 0220004 840 01 7945183503540201 T1F0R2DK01#EI 79451835 0354 104514855 069 1/1 1.0LB N EPA East Building, Room 6428 Washingt 20004 ZD RDVA DC-US DCA 32000470160000027945183503542014 50DG2/BDD9/7EFB