Document v6bBg18deaQqmqBJVYjk0qOb8

Institute of Occupational and Environmental Health Montreal. Canada THE RESEARCH PROJECTS SUPPORTED BY IOEH AND THE SCIENTIFIC PUBLICATIONS ORIGINATING FROM THEM 1966 -- 1976 Montreal, December 1976 ALV 001084? Institute of Occupations! and Environmental Health SUITE M3.- 3 PLACE VILLE MAMIE MONTREAL. OUE. CANADA KJB 2E3 m ^ lcoal ocaosit m or tn* wkwi ten Ou*M( National Ukrary II Institute of Occupational and EnvironmentalHealth in Montreal 1968- 1976 The Institute of Occupational and Environmental Health was established by the Quebec Asbestos Mining Association in 1966 with the objective of assessing the biological effect of asbestos on the health of the asbestos workers. The Quebec Asbestos Mining Association has in the past done its share in the field of industrial health and hygiene. The concern of the Quebec asbestos mining companies as to the health of the worker in the chrysotile mining industry included the development and maintenance of preventive industrial measures and the provision of adequate medical services through organized industrial clinics. These were established in the early thirties in Asbestos and in the mid-forties in Thetford Mines and were supported by such consultants and advisors as the Trudeau Laboratory {Saranac Lake, N.Y..) directed by Oc. Leroy U. Gardner, an eminent pathologist and industrial health pioneer. Professor Anthony J. Lanza (New York University) and Professor J. A. Vidal, a Canadian pneumologisl It was nevertheless becoming evident that new health problems were mounting and this to a point that only the implementation of an adequate long range scientific research program could bring light to the question.Such a research program had to be planned and evolved so that the needed points of comparison all over the world would be investigated, true as it is that asbestos fibre is reaching now into so many varieties of uses and commodities and at the same time becoming more and more of strategic, if not of essential, value to humanity. Accordingly the QAMA decided it should carry a sub stantial share of this responsibility and devote much of its resources, time and energy in that direction, being convinced of the vital importance of devising means of eliminating asbestos related health risks not only to persons engaged in the mining of asbestos, but also in the manufacture or use of asbestos containing products. For this purpose it was necessary to enlist a competent team of research people to investigate, advise, recommend and set in motion a plan of scientific research worldwide in scope. This ambitious scheme has over the past ten years been pursue with the guidance of the Institute of Occupational and Environmental Health and with the objective councelling of its Scientific Committee under the vigorous and enlightened direction of Or. George Wright, an authority m the field of pulmonary physiology and in occupational pulmonary diseases. Quebec Asbestos Mining Association. ALV 0010A4A Board of Directors and Executive Committee of IOEH 1976 Secretary: Marcel Oorais Robert Hutcheson Michael J. Messel Michael Prus Maurice E. Taschereau Paul-A. Filteau Put members of IEOH xecuf/ve Comm/ffee during th period 1966 -1976 Robert Coleman Or. Karl V. Lindell Dr. Robert Merrill William Oughtred Parker Smith Other past directors James A. Main Philip A. Meyer Ivan Sabourin. Q.C. ALV 0010850 PREFACE George W. Wright, M.D. Chairman of IOEH Scientific Committee ALV 0010S51 Preface The Scientific Committee of the 10EH assumed as its first task in 1966 a survey of (1) what was known about the relationship between occupational, paraoceupational and public exposure to respirable asbestos fibers and the subsequent health of those exposed. (2) what was known concerning the biological effects of asbestos fiber in animal or cell systems. (3) contemporary information-about the qualitative and quantitative aspects of ambient air exposures in the workplace. The various publications making up this body of Information formed the nucleus of a library of scientific references which has steadily been added to over the ensuing years as new information has become available. This effort, under the able direction of Or. Premysl Pelnar, the Committee Secretary, has been of inestimable help to us as well as to scientists in all parts of the world who have availed themselves of this source of information. This function is currently recognized by many as a major accomplishment of the IOEH. On the basis of their own broad experiences with respect to the biological effects of inhaled dusts of various kinds including asbestos, plus the information gleaned from the surveys just mentioned, the original members of the committee met several times over a brief period to define the areas where additional knowledge needed to be developed to produce a more complete understanding of the intricacies of the total problem. These areas were categorized in a broad fashion along these lines. Studies to (1) determine the nature of the biological effects of respirable asbestos under varying conditions of exposure such as those of mining, milling, manufacture and consumer use. (2) arrive at a better understanding of the mechanisms for the biological action of fibers including the facts with respect to deposition, clearance, migration and ultimate fate of inhaled fibers, (3) delineate as accurately as possible the past and current ambient air concentrations of respirable asbestos and coexisting agents to which persons were exposed. (4) evaluate the validity and accuracy of the methods being used in research germane to the above studies and (5) to develop new methods where appropriate. I ALV 0010352 The ultimate and overriding aim of investigations along these various lines was to provide information bearing on prevention of adverse health effects during the production and use of asbestos and to discover, if possible, means for preventing or minimizing these in persons exposed in .the past The several months spent in this pursuit was not with the belief that we could support research in all these avenues in a meaningful way. Th? magnitude of that task could be seen to be enormous and the desired pace of accomplishment beyond the abilities of any one group. Fortunately, other agencies in commerce, government and academia in several piarts of the world were, and continue to be, engaged in these manifold pursuits. It was our hope however that the committee's efforts in those first few months would enhance the probability that the resources available to us would be used as economically and expeditiously as possible. Over the ensuing years, somewhat to our surprise though not wholly unanticipated, it became clear that the multiplicity of specific avenues for research readily recognized by our committee actually exceeded the availability of interested, competent and experienced research personnel and facilities. In spite of these logistic problems, not confined to the experience of our committee, progress has been made. Considering the technical difficulties involved in the pursuit of research in this field, almost insurmountable in some instances, our committee believes a good yield has been forthcoming from the research supported by the IOEH. A major step forward has been the acquisition of diverse information developed under this and various other programs underway in laboratories throughout the world, to support strongly a conviction that the various health effects of respirable asbestos are dose related, diminishing in severity or frequency with lesser dose. Hence, reduction of total exposure to respirable asbestos lowers the risk and there is reason to believe that an ambient air level tolerable with no excess risk is an achievable goal. ALV 0010353 Much remains to be done, the bulk of it requiring long periods of study. Ouring the past eight to ten years exposure data more meaningful in qualitative and quantitative terms have become available. These data plus ongoing measurement of ambient air fiber concentrations and further monitoring of health effects will provide answers in ensuing years to some of the now vexing problems. New technical approaches to estimating past exposures may give us a better understanding of the relationship between currently recognizable health effects and the exposures responsible for them. New techniques of animal and cell system models might be used to arrive at a more complete understanding of the mechanisms of biological effects of fibers. These should be applied. Our committee is of the firm belief that additional studies are very much worthwhile and should be pursued with vigor. The Scientific Committee takes this opportunity to express appreciation to those individuals and groups who have pursued the research programs set forth in this volume. They have achieved! We also wish to indicate a sincere recognition of the unstinted support from the Executive Committee of the IOEH. Those research programs recommended for initiation by the Scientific Committee without exception have been supported by the Executive Committee. 0? George W. Wright. M.O. ALV 0010954 Survey of the research projectsjupported-by ,0EH and of the scientific publications originating from them 1966-- 1976 The Institute of Occupational and Environmental Health IOEH in Montreal was founded in 1966. To the end of 1976 29 research projects was accepted by its Scientific Committee and by its Executive Committee and supported through IOEH by QAMA.* A further 17 proposals for research projects were also processed by IOEH but not recommended for support by Scientific Committee. Four projects which were accepted were later cancelled for various reasons not related to IOEH. The projects accepted and supported can bedivided into the following groups of practical interest: I. Studies of comparable epidemiologic experience la the mines of chrysotile in Canada (projects #1. #10. #27) of chrysotile in Italy (project #5) of anthophyllite in Finland (project #7) II. Studies of epidemiologic experience In asbestos cement factories (projects #8. #16. #25) and shipyards (project #5) III. Studies of the epidemiology of mesothelioma among the general population (projects #2. #19). IV. Studies of the physicochemical state and transforms* tlon of fibres during technological steps from mining to appli cation of products and study of relation thereof to health expe rience of the exposed workers and to control of dustiness (projects #3. #11. #15. #18. #22. #23. #26). V. Studies of fibre dynamics within the body and of mechanisms of the biological effects of asbestos (projects #6. #12. #14. #17, #21. #28. #29). VI. Study of specificity of pulmonary rales as early sign of asbestosls. (project #24). In October 1973 IOEH organized an international confe rence of invited experts on "Fibres for Biological Experiments" in Montreal. Full Proceedings were published as"a monograph under the same name by IOEH. ~ I "__ ' Qu46c AsBsstos Mining Association XI '~ ~ ALV 0010555 ..Up to December 1976, 105 scientific.articles and books were published which originated from the research projects supported by QAMA or originated from activities organized by IOEH. These publications represent an important portion of the scientific literature on biological effects of asbestos and by their number and high standard indeed contribute a great deal to the current knowledge of the subject. We present a comprehensive survey of the research pro* jects accepted and supported by QAMA. In them we show the title of the project, the name of the principal investigator, the approved cost and a brief description of the investigation, followed by a list of published documents generated by the project; most of these documents are shown as a copy of IOEH filing cards which contain also a summary and code numbers. The coding system developed by IOEH is attached. It should be mentioned that a large number of scientific papers resulting from our projects were presented at confe* rences and some papers are currently in press. These also contributed to the objective scientific knowledge of the subject but they were not included In the present survey. Premysl V. Pelnar, M.D. Scientific Secretary A1-V 00103 CONTENTS PROJECT NO. 1 2 3 5 6 7 8 10 11 12 14 15 18 17 18 19 21 22 23 24 25 28 27 28 29 PRINCIPAL INVESTIGATOR -PAGE J. C. McDonald........................ J. C. McOonald........................ J. C. McDonald........................ E. Vigliani................ B. Pernis................................... L. Nord.................................... " H. Weill.................................... J. C. McDonald........................ G.W. Gibbs............................. P. Gross................................... W. E. Smith............................. G. W. Gibbs............... H. Weill................................... . B. Pernis................................... G.W. Gibbs............................. A. McDonald .. ...................... A. Morgan............................... G.W. Gibbs............................. J. C. Roy................................... R. J- H. Murphy, Jr.................. H. Weill.................................... G.W. Gibbs................. J. C. McDonald........................ A. Morgan............................... A. Morgan ............................... Survey of expenditures......... Appendix: List of the IOEH Code Numbers........................ 1 19 25 33 45 55 67 73 87 91 99 105 Ill 117 121 125 129 133 139 143 149 153 157 161 165 167 169 XIII ALV 001035? PROJECT No. 1 Project No. 1 Epidemiological survey of the biological effects of asbestos OBJECTIVES: All employees of asbestos mines in Quebec to be recorded and ex-employees traced. A random sample of current employees to be examined by a question naire and by a series of pulmonary function tests. The latest x-rays of all employees to be reread. The past dust exposure for all employees to be assessed. The mutual relations between exposure to dust, symp toms, radiological changes of the lungs and the impairment of respiratory function to be examined. The cause of death of those who died to be traced and correlated with dust exposure. Cost: $230,000. Dr. J. C. McDonald. M.D.. Department of Epidemiology and Health, McGill University, Montreal (Continue^ aslOEH #10) -. I ALV 0010959 aocv<ar at. Ir.ef or 2832 lodfitii nut * BECKLAXE M.R., FOUFNIER-MASSEY G.G., MCDONALD J.C. 6 R0SSITIR C (T cooc" 10 12 13 30 U3 60 70 81 1* kt oo on CM*n*CTcnttTic Relationship of functional to radiographic changes in Quebec asbestos workers. Paper presented at Dresden Conference, Biologische Wirkungen des Asbestes, 1968. Proceedings published 1973, pp. 207-214. K0M UOTCI * w in free u agb-dtrutlflod rudoe louplo of eurranl aeployoon in `ha Quint utntoi Xaiac taduatrjr atro atudlod rddiologleolly oad by lung function tnu. * aith deflnlta but atrip rtdlologlcal rrldoaeo of tobootoalo oboood raductloa U lug___ oluao tad axplrotorp tlr floo tad of (to dlffuolsa. ___ 3' tboro ato a elooo oorrolttloa botaooa profuoloa of ootll lmgulnr radio loglctl ope- -- oitlta tad dogrto of functional iaptlraaat. Tb* group oltb alalatl radiological ahaa- ___ goo' iboaod bigdip oigalfleant dlfforoaeoo froa tbo norati group. ___ *. Olffuoo plaural thickening, aloao or oltb aeooapaaplag paraaebpaal ebangaa, aai aaaoclatad oltb daflalta looa of function, opoclallp of oxplratorp flea ratio. .. can iiNItl IV w (trie av loocuHur . or____ ___ lUi______ 71 n I no 1L * Becklake kit aoao oa cm>cTiaimcSlemiatyc)c: , J.; Lung Function In relation to radiogri phle changes in Quebec Asbestos Workers. Lecture at International Conference on Pneumoconiosis, Johannesburg, S.A 1 RoaaicbgJ9T Rossiter, C.E. April 23-May, 1969. PrftgeedingaT . pi . 233-239.1970 PHRI.TRHFn TM. Hn11a1-<n Am phy io-path olagift resoiratoire. 6 (3): 637-659. Juillet-Septembre 1970 Tha relaiion.hip betwaan chati vray change. and pulmonary function wm Q ecxxatmmiiMneOd imn iann <*|* .wurnawifiwewd random .ample of I.OM men c--u--r-r-en.cy* em.ploy* ed / TAfii Laid. /U.Z-in the atbetto. indu_tt_r_y o_ tf OEu..t.ern rQt.uebk-ec. lIan uwiaoerkkoeera. Uw-hKoftl.` V.rat'l lhfiW(d IaI.jrTeftt BamnaananiHHiJaaflnML no avidanca whiieer ef parenchymal diwa.e. vital capacity (\C1 and forced _ vitei capacity (f'VU may have been iliyhtlv reduced, while in ihc pre*nee oe definite, though minimal.'t rey change, in the pulmonary p.renchyma il*M wara - the only function mca.tircment. to .how .ignifuint reduction. In addition, vu _ and cxcrcia* minute ventilation appeared to be the mo.t *n.itivc indicator, ot the progreu of radiological direaie. For any given grade of perenehymal duewe w. function we* tomewhat more impaired when plaural thickening and/or eatet* _ caiion wm present. This study tugjesu ibt th simple meiiurtmem ol~^C _ ** FVC should therefore be of value in the periodic health txamihartoo-of tho asbctlOl urorkaf *~ ftLV 0010S60 lOOCvatat I 36S7 `Becklake, Margaret R. , Fournier-Hassey, Gis>le, Ross iter,Chaffe?*E. t it ceot 13 TT tr .0.0 on tntTin.tT.c Lung function in chrvsotile asbestos mine and mill of workers of Quebec Archiv. Environ. Health. 24 (6): 401-409.June 1972 (vary similar rn FH 31 SB. Rff n^lr TTT-n-TTTI 60 70 *M (HIM m m m OtolrntMtok wiMm Mmoto a 1,911 OwkN MtMl wortm kow <u*t tipvtur* hok fenno wttMrt from thnir no#k hfctoiry *< mtlikto Ivto Imh In IM MiMlry. In noiumokon, m*> ml tonctlon ImU ktetkiovtoftok Oto lownf hn kuntkipoitiro (rouse Tkoto worn faupiritory fkpkcHy. torcnk im CJMCitT. ink foreok itpir* lory voiwno In 9.7% noowk Ml in 1.9 uoona. In imokora On urn toils won mwilul toon mnllki. Airy I On Into nmnUinok insnr k kn mitnkto tor hum tumininci M nkiiin nsoook worlwn, whitovor toolr irnnktof hikito. ftoomcat tint Biological effects of asbestos: (Lyon) M6< OOCWC*f Of 1HL WT COM 90 kit none on ciunicTinime KORf NOTtS Report of the Advisory Committee on / sbestos cancers to the Director of the International Agency for Research on Cancer. Lvon Conference. Oct. 566, 1972. Ann. Oceup. Hyg. 16 (1): 9-17, 1973 < irculated. Also published in Brit. J. Industr. 1 led. 30 (2): 160-186 , 1973, 1071, J-M - Environments: Facts/Asbestos. 7 pp. 1973. .. ^ -- * ^ - x- ALY 0010SS1 |-*8M8 * 1 - Ducic, S.: 1**18 M6C 0* 3622 36 Accuracy of causes of death - A compd rison with autopsy diagnoses 37 in series of mesotheliomas and other malignant tumours of the lung. 38 (Inexactitude des causes de dScfcs - L ne comparaison avec les dia73 gnostics 1 l'autoosie dans une s4rie de msothliomes et autres 70 tumeurs malignes du poumon). COMPLETE TEXTS IN FRENCH E ENGLISH) 81 Cdn. J. pf Public Health. 62: 395-402 . Seot/Oct. 1971. 39 Summary and conclusions In a series of 67 autopsy and surgical-pathological diagnoses of malignant mesotheliomas of the pleura and peri toneum, we were able to demonstrate agreement with the certified cause of death in 10 cases (14.71). In 26, mesothe lioma was reported as benign or, even if stated correctly, coded as another, tumour. In 31, the real diagnosis and the official cause of death were in disagreement. Of 56 autopsy cases of primary lung cancer and of 59 metastatic lung tumours, there was agreement with the death certificate in 73.2% and 72.0% of cases respectively, but there were marked discrepancies in a total of 21 (18.1%) cases. Physicians signing death certificates did not state whether there had been autopsy in 26% cases of mesothelioma and in 14.2% cases of primary and secondary lung tumours. Disagreements on the diagnosis of mesothelioma shown on a death certificate result not only from the difficulties in making the clinical or pathological diagnosis itself, but because of the lack of unanimity among those issuing certificates of the cause of death as regards the bening or malignant nature of the tumour. Finally, with the 8th revision of the International Classification of Diseases - especially with the adapted ICDA-8 - we can expect that at least some of the discrepancies will disappear because due to purely medical problems an accurate notification of death from mesothelioma is still difficult. m ALV 0010362 !*'( tv V COM 13 70 32 81 fournier-Massey, Gisfele MV WO*D 0* C*i*CT|UTIC THESIS: Pulmonary function in Qu4be< I asbestos workers. McGill Univ.. 168 dd. 1973 CIRCULATED: oo. 105-106 6 pp. I-II. I >_ - cvat 163 icon Norn an aouil *( ST ocuacar tmi nat Foumier-Massav, Gisile; Becklaka, Maraarat, MV COM mv *o*o oe CHAcTim*nc 13 II. - Epreuves da fonction respirato: re. 12 Bulletin de Phvsio-oatholoaie resoirt toire. 70 6 (33:661-687. 1970. 60 TT. - Appendiv Teer* of respirator} function) 76 See also 315k) 81 ncvaw m or iactri3 362 R. et al. : icon iom QIB8S, 0. W.: Comments on standard intamatlonal methods (or valuation of asbmtoa dust exposure. Psmis, B. and Pelnar. P.: Transeript of tha Moating of tha Sub-Committaa and Intamational Colloquium on Asbastosia, Sardinia. Saptambar 24*26,1970, Montrial 1972, pp. 18.19.20. ALV 0010963 !2F ocvor firvc M6I CT COM 2 3 b 59 i;n 76 81 U3 S3 tr oao on enaaatTiBUTie D.icf nxpmc.T.n in rhn ehrvsotiln athr stos mines and mills of 0ueb.Cj_ Arehiv Environ Health 2bJ_ 189-197 , mbunf Md Miune anvbcnmenl and *** need ! aatrtllab Maaa at wpaaura tar apliimlc " ta|laat abadlaa at* daacrtaoc irntranmentol dual Milaae vara derived mainly Irani tyalomatlc mldnaldMpMger aampiaa taen tinea IMA and bant SaM . afir d adiar lachnlquoa. Thoutb dual law* -*mm Ma Mduetry Ituetuatad widely, Mere vac a alaodr .......... tafl 1mm m rrorofo aopfonmatonr tv miwm ** -- ntAU 4mA y 1|4A Am* *---- wn 1 MSCS la IMA Canaldarabla variation m Ma content ef airborne dual m Mia Indvary Idea armmml at fibraud and itanibiaua anmoanarda- JS 07 %con **oitv OOCm fT COM 3 69 76 JLL !SL Gibbs , Graham William 8 Lachanct, Maurict: kit kowo oi CHAHACTtmync Dust-fiber relationships in the Ouebic chrvsotlle industry. Arch Environ Health, 28 <2):69-71, Fb. 197b tpMM itcal atudleo at Quebec chryaedla minara and millere have related rartoua indicea at heairn te dual iipa , aura, aa maeaured with Me midpel Ino proper. Tha interpretation at Mere raia' eonoMpa In lanna at llbar naeaaaltataa . Via cortvoralon at miagat implngor (par* Ida a Hbar) eounta la membrane llltar ' (fiber) eeuivoienta. An toveebpatien in wMdi IT aidoby aide midfel Implngor , membrane llltar aampiaa were takan at lira mined and mint chewed Mat Ma ear* ' retaden araa paar and na alnfla eonver* . aian Iactor araa |uaun*d. Unoi mare dm tailed Mormetlea on Me ralaUanaltlpa ' bataraan midget Implngor and mambrana . mtar eounta can be obtained. M la recene mawdad Mai aately atandarda. at lead In ' Mia Indualor. altagid eontinwe ta be baaed - an dual eounta. lor wfuch Mara la cenold- _ araWa epidemiological tupeort. raMar * Man an fiber eounta, lor which Mara la na - direct arMrnca. J2- OtCVMtfT . 3918 tCOfC KOTIt ALV 0010564 04| - OOCwat fiWI flat 12 76 01110 0t - I0"I0 0 "0*6t ILO U/C 1971 Internat. Classification, etc. air woao Oh CHaaacuaiSTic ILO U/C International Classtficatior of Radiographs of the Pneumoconiosei Medical Radioeraohv and Photoeraohv, 48 (3): 67-112. 1972. (Published ir Enelish. French. German). Cireulsred English version pp. 66. 76; plus pp. 83-93 S p. 105. - 0OCMIM0f m. 00 lil Kort corn KtecoOl 71 7T Al - pocvMlaf m 3570 lacanea Jcdoin, Gillas, Gibbs, G.W., Maclclem, P.T., McDonald\ J.C. I it woao on cmeacrueirnc SecfelAlc^ MAT*ytHPgR. Early effects cf asbestos exposure on lung function. Amar. Review of Respiratory Disease, 104 (i): 5S5-535 , Oct. 1971 im ia uimpt to dcfUea the mriy ilm W tibewna cspenirt on luaf hiactioo. detailed ttudim. la* _ dudlag taua at pulmonary morhanlra, were adt an 14 mitin kt had normal dm radiographa but whom exposure ia album nap* boa man(ha m U jamre. Tha IS an with |mur pawn ahowed. an tha avenge. * tighiAcant JO par ami incream ia tha tutia nail ol tha lane . when compared with tha II aaa with tha lamer aapeaum. ta addition, they had uaallar rltal <a> padbaa, evidence ot polo ragioaal Inhomnganaiilae a* ventilation, and larjrr maeleul aid- ' etpintcry Bowt. changes ia keeping with the preaena ol a temrioire trpa ai lung dleeam. tf antrmc. at any given tnnapulmonary praamre. peak Roar u lam ia moat ol tha man la tha mom aapomd group, indicating aa Incramd opatraam rebalance. Thin suggest that the chaaget rmpenilhle lar the incmaad alaatk raooil had a peribronchiolar rather thaa aa alvaolar lomdan. la keepkv with what haa baaa thowa fat laboratory aniaub. The change* ia pulmonary Khanka were natldiiil ta be earty hamam they occurred la mca who had aa ndlcgiaphk avidmm at > at dedaillva changes la atbm meuurvmenu ol luag ftiiactlca The ladlap i i dual la incchar mum ol obametiva dimamW email airanyi sums e*(i . .-- "'- -- inocx/tsacino capo - 10 -- n ALV 0010965 ill IT #9Cwar tifwl * McDonald, J.C.: " *( COM 70 Research on Asbestos and Health: 10 A progress Resort to Emolovers and 36 Employees of the Ouebee Asbestos 38 Mining Industry. 43 McGill Reporter. 2 (24): p. 18, 10 , (pril 60 81 1970 (see e tOCt1fiM139 I0EH 3234) . wri 7 nr coot 2 11 15 60 /a ____81 i.siii* |cr<* *. oocumet . ! not or 3497 locates * McDonald. J.C.; Becklake, Margaret; Fournier-Massev , Gisile & nr *0*0 CMcr*ime Ross iter. C.SVfoTM* asbestos mine and mill workers in Q\ tebec PUBLISHED: Arrh Environ He 1th , 74 (6): , May 1977 A standard questlonnaIra was administered to an age-stratlfled random sample .. of 1015 current male employees In the Quebec asbestos mines and mills. The prevalence of bronchitis, defined as persistent cough and phlegm, vas related most closely to age and smoking habits but, In non-smokers and light smokers. - also to dust exposure. Breathlessness on exercise was related to age and _ dust exposure but not to smoking. (asm mm Sti INOCX TRACING CARO % Z ALV 0010S65 ALV 001096? |r coot JJL 36 -18_ 43 JLflL 70 XL. (T wo0 0 CCTIHTIC Mortality in the chrvsotile producing industry of Quebec: A progress report T.rtiir* at TV Internet. Conference 01 Pneumoconiosis. Sept. 1971 in Bucharest, -BBj 232-237 in Proceedinjs. From th# report* o( ail ptrmni wcr employed in the minn and milla tor on. month or rm a TMh* "f wl.LdJ? il women, born 1M1--1920. was defined and it b*n< kept undr ewe* review. Environmental dual eounU and derailed hhaave beeQn| uied ima t3o22c1alc(2u1laptetfincdeinete)* woetrexkpnuowurn to hove died* IM irom lw ctn^. S (rim muliVnant mesothelioma and JI trom pneumu. TotaPmortallty continual to be lower than /.*"? population except In a tmall proportion heavily exposed to duit. Pulmonary fibrosis and respiratory maUananciet are the main eauteof the exceia which seems directly related to the indlcea of exposure. The ImpUcaUona ot three flndinf* and their relation to those ubaerved under other condltlona ol asbestos expoeure wlU be discussed. KOM voter ar ~ *MC * (0*rri | Uec lOOCUMlHt or 3484 MV coot 0 12 30 . 31 70 81 ROSSITER C.E.,BRISTOL L.J.,CARTIER P.H.,GIBBS 6.W.,GILSON J.,G T.R., kit *o*o 0* tM**cTtsne SrEMLATYZQG J.. tcort notcs SLUIS-CRDO G.K. 6 MCDONALD J.C.: Dust exposure and radiottraDhic appearances In Ouebee asbestos workers. Lecture XVI Internet. Congress Occup. Health. Tokio. Sept. 1969. In Proceedings 1971. pp. 20S-206. . la ihc Oucbcc asbestos-producing industry dual measurements and annual. I chest radiographs of employees are available (or many yean. The estimated 1 exposure (or eaeh of 13.000 worken has been related to changes seen in their | radiographs using the UICC/Gncinnati classification. There is a clear relation 'between exposure and the profusion of irregular small opacities. The degree' -and distribution of pleural thickening are also associated with exposure. Calcified' .pleural plaques arc linked with employment in one particular area but are. .virtually absent elsewhere. ___ ALV 0010368 C COM o 2 12 30 31 43 60 70 81 t *o*o o* c*etiiTie trnTt-rRrvrR r,.K. MCD0NAL50**-orti j.c.; Radiograohic changes in chrysotile asbestos mine and mill workers of Quebec. Arch Environ Health. 24 (6): 388-400. June 1972. Madlefrephlc to tl.ni anpieieee aiavalcaee at reunded'amall epaelllae (calaeory 1/0 w more) row win IneflMtof dual eapeaura i/a mi manl Iron 1-1% n . . 17.0%; an* tool ol pleural lWelahtop <0'*d* 1 or man). Iran 1.4% la U.1%- smn apacniae 1.1% has balk. At pretenl 4wit etpoture levela. much Icwof nice can be *ipected. The provn IIIKN M rifiMwflC CnWfia iii^hi n uiv Thai/ard Mlnoa aroa nan to na Aabaaiac area. .. Tbto waa ahewn bp plaurai chant** man nan pannchyaial change* end no dlRannea waa ' eitiama win pleural caldflcaUea which waa cammen to TheHerd Ulnae but virtually abeent n Aabaeiae. | i - & ocuMcaf n. MCI ii. 3607 CCY COM 2 3 76 KIT WORD OR OUMUCTtaimc Evaluation of asbestos exoosure in t he Working Environment. Industrial Medicine ( Surgery, 41 C 28-30. January 1972. scoaaaoTts ments SUMMARY: A working group of Sub-Cor imittee on Asbestosis oresents its internatiom 1 agreement on standard methods. Alan puhlinhed in: Work-Environment- Health. 8(3):71-73 . 1971. " " " J. Occuo. Health 14 (7): S60-562. July 1972. " " " La Medieina del t avoro. 63 (1-2): 1-6.1972. " " " Gigiena i Sanita* ia 8 2: 76-79, 1973. " " " Medicine de Empri ise 8(3); 248-251,0ct. 1973. ALV 0010363 I I !'< If I XT cooc 12 --FT" 76 UlC^^Worlcin^^rou^)^^^______-- HIT 00 Qt CwAtCTKl$ri{ UICC/Cincinnati classification of radiographic appearances of pnnumoconiosis. Lecture XVI Intarnat. Congress Occu; . Health. Tokyo. Sept. 1969. pp. 179*181. Proceedings 1971. _ scon oru ^ Bohlit, H., Bristol, L. J., Cartisr, P., Clarks, W. G., Prison, B., 1 Gilson, J. C., Graintsr, T. R.. Jacobson, G., Kivudote; R., Me1 Donald, J. C., Ptndsrfrass, E. P., Rossitcr. C. E., Sslikog, 4. J. 4 Sluis-Crtmsr, G. K,, McGill University, Montreal, Canada Three interested international groups have extended the 1LO 1951 Classification by differentiating between the small rounded opacities frequently seen in mineral pneumoconiosis and the small irregular opacities seen in asbestosis and some other pneumoconiosis. The other main extension is the grading, by reference to standard films, of pleural changes. The practicability has been confirmed in 42,000 readinp of over 15.000 radiographs from the Quebec asbestos industry. Twelve readers from six countries have also tested the classifi* I cation on 100 radiographs. Inter- and intra-observer variabilities are similar to those in trials using the 1LO Classification. s-ac---!OlIN ICOII i IN0CX. TRACING CARO l - 15 -- ALV 0010970 PROJECT No. 2 Project No. 2 Epidemiological study of primary malignant tumours of the pleura and peritoneum in Canada OBJECTIVES: All cases of primary malignant tumours of the pleura and peritoneum that occurred In Canada since 1960 to be registered and two matching control seriea to be found! one series comprising patients with secondary malignant disease of the lung. Relative importance of previous exposures to 1) asbestos at home and at work. 2) other environmental carcinogen, 0) tobacco smoke to be investigated in the epidemiology of mesothelioma. - Cost $6,940. Or. J. C. McOonald. M.D., Department of Epidemiology and Health, McGill University, Montreal. - 19 -- I .1I ettte tt <* MCualaf^l ^Macner. Desmond McDonald. Alison r . KCTCOOf K|T *0*0 0* CMA**CTC*ITIC 38 Malignant matnrhalial rnmoeA_------0 histologic tvoe and asbestos exposui ke. 1 New England J. Med.. 797 fill: S70-! 71. 73 Sent. 14/72 60 91 Roval'College of Phvsicians and 63 Surgeons of Canada. 6o. 58. 1973. 70 81 iei OQCweltt M or 3734 voc*'** score votes art . Vf. KCY COOC 38 70 73 5T--------- ibniii if mm it ' or McDonald, Alison D., Magner, Desmond 6 Eyssen, Gail: OCUMCKT a#. 3824 W0CAT** KCY WOOD 00 CMAMACtfMtfne ' score ora Primary malignant mesothelial tumor! i in Canada,1960-1968. A pathologic review by the mesothel; .oma panel of the Canadian Tumor Reference Centre. Cancer. 31 (4): 869-876. April 1973 Six peihologittt reviewed tit f IBS cam reported u primary malignant m thrllal turnon. between ItM and IMB, ia a Canadian national turvey. Bated a hiatologic obacnraiiona only, the panel waa in favor of the diagnotit ia MB, uncenain in NB, and apinai ia MB. Thia diairibtitioo wat timilar tor pleural and |icriionral lumon. Ia main, the diagnotia waa favored more often I than ia ittiulci--(IB compared id MB. Qiaical and additional pathologic information changed the pathologittf* opinion little. A member of the UK Meeothclionta Paarl who reviewed 44 of the lit caaee recorded naemiatly timi lar opiniona. Subtctjuently. a farther 71 catn were rrfiatrred between ItM and It70. aad reviewed pathologically. The tt cam ia all. ia which the panel favored the diagnoaia of aulignaat mesothelioma, had been ci|ioted to at. bcatoe tlightly more frequently than the rest. Twelve of 2f <4<9) tamnra j datai&cd hiatologically aa mixed were ataociaicd with atbeuas expoture compar<4 witk M 73 (11%) diwM n epithelial or acwochymaL INOCX, tracing carp ALV 0010573 f Wi ct coot 38 nr 73 >401 08cior * 3879 McDonald, Alison D. S McDonald, J. Corbett: >Q 0e 6 CX4t4CTtttTC Epidemiologic surveillance of mesothelioma tcort *oU in Canada Cdn. Med. Ass'n J. 109 (S): 3S9-362, Sept. 1,1973 Surwniry: Th# numbar *1 lalfi m*bfl<Mht motMl*omai 60 61 wta Mcwuinad lor Iha pnd 1MO-70 by contacting al pathotoyitta in CanaOa. Tha annual inaibonoo woo toady botwoon IMS ano IDO al 1.0 par miibon population. 63 01 71 catat rogiotorod a* 1*00-70 aaS no! pcoviouoly 81 reportod. #0' ! wars plowal. 20" > peritoneal and tho remaindor in both titoo; *V; Ol tianouro wore in woman. Tha diegnotio ol maooihohoma woo approrad by tho Canadian Moooihobome Pano* m If-. Si*ly-nino eaoao wars aueeaaaiuUy mvoanyatad apidarwoioflieally. A Notory ol dalauio or probabio occupational aabaotoo oapooida woo lound in 20*1 ol malo caaoo comparad with 11* of controls, but in nona ol tho lamala caaao or conbols. However. among cats*, lota woman and ano man hod had domsatic aspoauro duaty elothinf of on aaboatoa wordor. Moat of tho oacoaa oeeupationdl aapaairi waa in tho manulaoturo of aabaatoa produot* or inaulation and linio m mininf or milling. No caao othar than ihoao occupobonaOy or domootioaby aapoaod had tvod within 20 milaa ol aaboatoa minos or miia. laKiia a? eocwitsaT Tina McDonald, A.D.; Harper, A.; El Attar, JL i CMsaacnaitnc ^Epidemiology of primary malignant i teaothallal tuaoura in Canada. Lecture at Intarnational Conference on Pneumoconiosis, Johannesburg, S.J. April 23 - May 2, 1969. not O.A. 6 _8_ 315S loot** McDonald t JiCt! KOft iom ef Summary of Results; An association with definite or probable occupational exposura to asbestos was clearly demonstrated, but only 20% of male cases and one female case had any such contact. Almost all the excess was in the manufacture and industrial applicati of asbestos rather than in mining or milling. No association was found with lesser degrees of occupational exposure or residence in asbestos-mining areas, but there was a small excess of possible domestic exposures. The smoking histories in the- mesothelial tumour amd main control groups were almost identical and unlike those for .cases of primary lung cancer. PURTTCwm jm. Cancer. 76 (4); 9144919; -Qe-toher 1970. ^KUGEfcDlNGS Internat .Conf . Pneumocan ios'is.~**DP. 197-203, published 1970 (received 1971). ~ PiLV 0010974 PROJECT No. 3 ,, .? 23 Project No. 3 Chemical and mineralogical studies of chrysotile asbestos with particular reference to oils and waxes OBJECTIVES : Samples of rock and dust to be collected in a carefully controlled manner, pulverized and extracted with organic solvents. The extracts to be examined for polycylic hydrocarbons and other chemical consti tuents. The aim is to investigate their presence prior to any processing of the rock. Cost: $17,750. Or. J. C. Mcddnald, M.D. & Or. G. W. Gibbs. Ph.D., Department of Epidemiology and Health, * McGill University, `I Montreal. ftLV 0010976 ALV 0010377 ATI aeuil (KKB tocviur MCI Of 3402 KCT COM xte neap ea exiaacTtaiSTic 0 Oualitative asneets of dust exHASurg 2 in the Ouebec asbestos mining and mi Lling b industry. 6 --------- 7--------- ---------8--------- 43 60 - 3rd Svmnosium on Inhaled Articles. BaO.H.S. London, Sept. 19 0 Proceedings published 1971, do. 783- P99-. -- 81 - KOK ort * 56 - L .. -- ABSTRACT - Recent epldsalelaglcal studies of workers caplayed la tha Quebec asbestos alnlng and anting __ Industry hava described relationships bvtvaan dust exposure and ledlces at health. Tha quality as m aa tha quantity at dust te uhleh varkcr* ara exposed varlas within and bacvaen alnlng operations. This -- report describe* sole at thaa* quilltatlv* tartars, vlth particular retcranea ta etjanle crnstltutats, ------- _ trace netals, dust alreiilcjy ar.i radioactivity. Lavals at alrlarne polycyclic aro.-ttlc hydrocarbons __ In atlla, and lavals at radon dau;!itcra In unJcrgreunJ rir.es are hath eaasldarad raa law ca play any -- significant rela la tha lung cancer aertallty In this Industry. The trace natal eentaat at cocsrrclal ------- fIbrs varies batvaan nines and alrbarna trsea natal cenceatratlena la three nllla Investigated were __ found ta exceed lavala reported far taxtlla plants. Tha Ispartanea at duat cheatstry. physics, and -- alaaralegy In expariaental and epldealeleglcal studies at tha affects at asbeatea Is discussed. ~~~ ALV 0010078 I aL tlTU ~ VGlbbs. G.W.: KIT COOC ct neao on cnaaacTiaimc 8 Collection and storage of samoles i n 56 organic geochemistry. 76 81 3U: 629-630. 1970 * Kent aorti - i 4ATI I8NIII IT (*?( IT HU OCVMUT . Of 3S08 MCVKliMtf ^ O Gibba. G.W. S Hui. Hubert Y.: kOCATlM IT COOC onMr aroao CHnaacrtaitnc ICOfC NOTH s The organic content of Canadian chryi lotile. 1 7 60 A;-m---oriea'n Ind..u...s..t.r..i.a...l...H.Va. ASAj 32_( 3): ' 519-S2B. Aug. 1971 61 i 43 'I .1 7c ---- .a " 60 --_____ The wnnk mount at eanunertklly aOM Canadian chrywella * (annd U nm (mm U IM ( p W f>. depending ha watte d (her. That ylet* ntnM Hum (mm trld ipcdmoH la U eatee meepe eae, and Indicated caatamlnatka by mining and mlUln* placemen. An dcmcuial analyek and tha ar(iak extract! M canuln cwlmn (l Jd a* MAS**), hydregen (IIAf ila 1J.MW), and minar emotion a( ether Clemente. Infrared and gal ehramatagraphk aamlnatlan conArmed nalkanca u be the nu|ar couMltucol*. The cancentralkn at uetTcyetk aromaIk bydeeatbrnm In milled Gber MI caneidcred inn Imr w play M Important tab bi tarclnfcomb. The impaeuaca and warca al malkaiice and taut ecgaek caniajnlnatka we dbeamed. ALV 0010379 *T COM UT -e- TF -5-981 * Gibbs, Graham W.: *tr r00 QO cw*CTli|TIC Gibbs. Graham M.: Xha organic geochemistry of StlTyafltiLe. asbestos from the Eastern Townships, Quebec published in-Geochi Coasmacehnim Acta., Ii J'(4%S.Sc\} /ifl Kn <orn Extractions of selected speclacns of chrysotlle from the . Eastern Townships of Quebec yielded small quantities-of organic material. Infrared and gas chromatographic studies Indicate the `presence of predominantly n-alkanes. These were probably derived .by distillation from Precaabrlan sediments although a magmatic origin Is not eospletely ruled out. Sample collection, handling, 'methods of analysis snd problems associated with such studies of --(-chrysotlle are discussed. PMI0IW . w ma l|.ii INOCX/TRACING CARO ALV 0010980 PROJECT No. 5 ALV 0010381 * t Project No. 5 Epidemiological study on the biologica1 effects of asbestos dust at the Balangero Mine and among the Port of Genoa and LaSpezia Arsenal insulation workers Epidemiological study of all workers past and present of the chrysotile mine and of a representative cohort of insulation workers from the shipyards and environ* mental study of their dust exposure. ' Objectives are: 1) Ooes the inhalation of asbestos fibres bear any relationship with: a) the occurence of carcinoma of the lung; and/or b) the occurence of mesothelioma of * the pleura and/or the peritoneum? 2) Oo people exposed to the inhalation of very low concentrations of asbestos dust, such as workers exposed to concentrations well below any threshold t limit or people living in villages in the vicinity of asbestos mines, exhibit an abnormally high incidence of calcified pleural plaques? 3) Do the different types of asbestos behave in the same way in regard to lung cancer, mesothelioma of the pleura and pleural plaques, or is one type of asbestos prevalent among the others as a causative agent? Dr. Enrico C. Vigliani, M.D., Clinica del Lavoro. Milano, Italy. Cost $85,000. \" `1 ._ ALV 0010982 *CT COM 10 tr 12 13 36 37 38 43 60 70 es mr oo o* cmutcmuT'c The risk of asbcatosia in a mine of chrysotile asbestos (It) (II rischio di asbestosi in una miniara di amianto erisotilo) La Medleina dal Lavoro. 63 (5-6>: 183-212. 1972 KOM VOTJS ------------- ------------________ - ------------________ _____ ' ' ________ ________ "" _____ ------ ________ n. ------------________ ---- The Authors have carried out study of tka utn ot death aad a study * ** .^.i niifr-niirtnr on the working population of a bum of ehrytoule sibctiot m mUnMroTlaUlitnM. between t*)2 aad lW. 1W* fkmUwo(W for al kail ^ ikM. 242 won al work on March JIM. IW. Infermauons could ko obtained ia workers, that u *04 7. of the total popukmua. 170 subjects have died: a of (kora lU TJ died from long cancer. Mo bu o* serosal mesothelioma w ascer* uiaod. Th percentage ot look oncers was aoo ugmHcinil> dilfrrent fiom that ok* wvod I aula subject* of the same age. who died m ika tame period ia two town* gf (gg un, br< ika hum is uiualad. A eJintco-radiological aumnauoa aad a Mudy of tka rtspirasory luncuoa aa*a been carried-out ia workers at work tinea more than ggg ygg( ;pj ~ g( 474 subjects ihr-cd hi X-ray pattern cUsuAaOle in eatagoriaa l. 2, aad J of ika Cocuoun claiiifcaiioa; ika highest percentage of tukiccu f4l.( %) iik aknormal X-ray pattern wti ohonod ia ika groups al kigkatc risk. 31 subjects ikirard Abrouc ckangaa of ika pleura. 10 of -kick with calcific ogaaiy. Tka laagora* ion funcuoo lest performed war* ika vital capacity, ika maximum expirsuoo volume gag iggond IVEMS). ika alveole-capillary didutieo al flu aad al work (uaady ttaM atatkodh half sublets with abnormal X-ray gauara showed a ventilatory insSAtoency raaincti*a ia type, -kila approximately one third thowad a damage of al*aolo<aptUa mfluaioa. la 14 -orkart with a comglatcly normal X-ray pattern. aa impairment of atyooUr-aagiUary gat dilfuiioa u damonuraiadt ia al least 3 of ibata cases, all aa kith risk. ika existence of any oikor gotukla paikologtc cause, axeaga tiketloa sign- on could ka rulad uot 23 7. of ika worker* who received phytic si examination, mi found io have chronic bronchitis; no correlation was demonttraied beiwtea chrome bronchitis and asbestos exposure. Tka physical caaimaauon thowad the asiuanea at Ins cragium rales al tka Iboras base* ia 27 7. subjects with abnormal X-ray gauara; Ika highest pareanuga of subjects with Aaa crrgiiaal rales was detected ia ika group itt tka highest risk. The taking was present also in 7.3 % of tka rsdiologiaUy normal subjects. On the ban of the clinical aad tunmoral data, it asam posable to coalra that aa impairment of tlvaolocapillary dilfuaion of gases sad the aggaaraac* af hibaatar tar erapitant rales can consoiuie ora of the early conaequracee of expo* sura in asbestos, even in tka sbecnes af pieum-pulmonary ckaagas radiologically evident. I6H U W> U'lia iNOix/mciwe capo - 35 - *ri 1 Uifif OCvMftal fni _ __ , ^ Ghezzi, I., Maranzana, P. 6 Zannini, D.: MV COM 3 10 36 38 60 61 B(T WOOO on CMaeaCTieisnc Considerations on asbestosis in Pied mont, Lieuria and Lombardv. (It) (Considerazioni sull'asbestosi in Piemonte, Lieuria e Lombardia). Medicina del Lavoro. 62 (2-3):lll-ll 9. 197J., ecwatjr m. * Of 3586 iiurw kom worn 63 15)0 twtHl were compensated by LNA.I.L for asbestos pncumoconums ui Piedmont and In die prosineee of Milan. Bergsmo and Genoa: out of Umm. 1105 worn stdl 43 vtng m March )l k. IfTO. Tho aibnum of moderau or advanced done consdMad 31 jj % of tha cam; such percentage waa hither than 50. if one considered onh'Tfcworkers aha had been employed in the teatile industry and in dock-yam neural 30 change!, both calcific and not. were radiologically demonstrated in 51 % of aabiMime subjects who had worked in tactile mills, while smong the former chrysottle miaan 42 such changes resulted to be present only m Ia % of the subjects. Out of the 325 daM 70 worken compensated for asbestosis. I5 (57 *.) died due to causes directly relaud to ulMMii (corOiofCspirotory intulRdcncy. igbtrcwlotU. plturtl lufl| luwonfu 8S Pleural and lung tumours ware found in J4 subjects, that is 10.) * of the dead ntsc such parentage rote to UJ V if one considered only the <1 autopsied cases, la Id of whom the presence of a pleural or lung neoplasm was found. The incidence el pletml and lung tumour! was maiimal (I9J M among the former insulation workers, and esnimal (14 ,,) among the ea-minen, who had been exposed only to ehrywdlr. In this Iasi group no pleural mesothelioma was found. trains the epidemiologic dam. the resulB are reported of add measuramenm el air diUncm, earned out in as many work places: in Id.J % of the count*, the sellnee eoneantratioa was higher then 12 fibers/ml. The maxunnl coneentraboa of uhmos waa nbaened in the atmosphere of a teatile depersmem fcardinaX ftef. -Birqfc-A I," 11,111. Il - MW nil IMlt INOCX/TRACINS CARO ALV 0010S84 I * fiHI K|T COOt 12 --n-- 60 --51----- 62 63 70 es MCMvuir m. ! " or 3839 Sartorelli, E., Zedda, S., Aresini, G. 6 Ghent, I.: tcort eOTgg Respiratory phvsiopathology of asbe itosis (Italian) (Fisiopatoloeia respiratoria dell'a ibestosi) La Medicina del Lavoro, 63 (7-8): 2 59-281, July-Au*. 1972. . I id mum ooumed can be tummamed follow*. A ventilition inteAcwncy rrttnciive in type wa* obwrved m II * uiytct* of the IN (roup, in 10.1 *. wbjacta of tho 2nd irony and i II.I l. 41.* and M2tubiact* of tlw Jrd, 4th and life group rttpectively. Tho Aiding of ventilation inauAciency retirictivo in typo in t non-negiectable percentage of tubiecta oymcf to atbettoa. but wub chon X-ray Itn- dinp normal or dubiotn. won to indicau tho caittonco in thcw cam of pulmonary lotion* Mill not detectable radiolofkally. but that mwwthclcsa hav* already determined a chanp in lun| elatiidty. A ventilatory inauAciency obttructivt in i) p*. duo to chroma bronchili* with or without lun| emphywnu. wat obwrved in percentage! variable from I t.l t to 20 *. accordinp to the (roup conuderrd. In tubiecu with a cbett X-ray pautrn dia|noatia of a wvera atbeatoti*. evident chance* of the rate ventilation/per* fuiion fincreaaed rnpiratery dead tpace and a-A COr gradient! were often preterit. A reduction of Dico at row and/or at work, below the loweat normal limit! (defined from the uudy of (I normal male Hibjectah a* obicrved in 4.4 to (.* tubjacti of the IW (roup, in M to lt-2*- subject! of the tecond (roup and in percentage higher than 20 (up to 100 *. in the aubiecu of the 3rd. ath and Jih (roup. The finding of pathological value* of Dt.co both at ran and at wort, m a certain number of aubiccta c*po*ed to aabeitoa. but without radiological changer or with X-ray changm intuAdcnt for dcar-cut diagnotia of isbcttotii indicated that the pulmonary kdcnc induced by aabeitoa can deternun evident functional changer of the alv*olar-capill*ry [ eachangea alto in a pre-radiolofical phaw. In conclusion. the uudy of the tup- t ratory funedoa in worken capowd to aibcwot olfcm uwful data not only for an era* luadoa of the functional damap prtwnt ia the tubiecta with an ubaatoaia evident at X-raya, but alia for an early diagnout. and therefore for the prevention of aabeatodo pniuiiimonindl. l ..- A Uudy of the rtipi/atory function wet carried out in 724 male subjects nnuwd 'do inhalation of asbestos dual tworktri of a mining company of chryvtile in hwdmunr. intulaiort: worker* engaged in 'he (traduction of albeito*-cement, of utbcsti* ictule* t or of car brake* ami friction dutch ditctL In all subject* ihc vital capacity. Vt-MS and Dt ni at rcu litcady ttata mclhodl were determined. In tome caw* it an meatured the rcaidual volume, the rmitancei of the airway< (body plvnunogranbvi of re- ipirttnry dead tpace. of arteno-altcolar CO- gradient and alto of Oirn at work, on a cycloergomclcr. The subject* were lubdividetl into 5 grnupt on the hau* of the t cheat X-ra> pattern lUICC elaiiil'KaiHM. Cincinnaui: lu group wuh X-ray paiiemlin or 01 and with atbeuua cipouire leu than 10 year* lavcr-iac-ciDudite 5.7 yeartr. 2nd group wuh X-ray pattern uo nr O'l and with aibeito* npwrt longer Than lit year* liverap eipoture 21.2 ye-irtk )rd grimp wuh X-raya I 0 <e VI: 4th group wuh X-ray* 1.2. 2/1 or 2/2; 5th group uuh X-ray* 2.J. | ' or ),1 -- - - -- ALV 0010985 1 4ft HKI If % MCMIif ftfU .... v k Jfigliani, Enrico: CUI IT MM cev coo< 20 N fibrogenesis. The fibrogemc respor se 21 to asbestos. OAMA 2nd Antieua Conference IV: uu 151-167, Nov. 22, 1967 us Medicine del T.evara 59(6-73:40148 410. 1968 73 1 85 - OOC*|eT if OP 2870 IKIT4S KOff atom 1 *" v ocvac* tint KfT COOt 2 3 40 43 45 48 85 --- IT (Til IT OOCwwCef l MM OP -kOC43TiO333 Vizliani. Enrico C.: *,t *o*o o* CMUMCTtaitnc KOPf NOTfl Pri+erie far dererminetion of MAC of silica and asbestos in the air. It.) (Criteri per la determinations dell 1____________________________________ concentrazioni massime tollerabili di silice e amianto nell'aria). Med. Lavoro. 60 (2):85-89, Feb. 196 1. (List i uf'O ~~ The paper given at the International Congress of Hygiene and Preventive Medicine in Rome, 1968, describes in some detail the Italian hygienic norm for prevention of silicosis: R 5*000 where R * hazard of pneumoconiosis q s % of free silica in dust N s number of particles <5 micron in 1 cc of air Otherwise it summarizes knowledge of the*date on measurc-e*.: of dustiness in various countries and particularly on the problems connected with evaluating and measuring hazard of aOfcbettcs exposure. ALV 0010996 AfC ' Uhui * M aocu.cnr riTvc . * Vi!gliani, B.C.i at .1 U*Ct * 09 tocvsut tecaiij#" IT COOf 70 bu 61 n 62 36 3B 65 KOH 0T1I Asbestos Exposure and its Results in Italy. La Medicina del Lavoro, 60(5)i325-33< , May 1969. (paper read at 2nd International Com erence on Pneumoconiosis, Johannesburg, Apj 11 1969). SUMMARYs Of 307 deaths among asbestos: ,s compensation cases in four Italian provinces, 31.6% died of asbei tosis, 10.8% of. cancer of .una and pleura. A minority of subjet its were autopeied, and these lublects exhibited a higher mortality from aabeatosis, 42.4%, and Lung and pleura canc-rr,* 77.1%. The < uthor comments that the number of lung tumors found at necroi sy is rather high." Four tvDes of asbestos workers were stucie^ 1; miners, textile and frictioi products. asbestos-cement. and insulai ion workers. "Mining ias the lowest and insulation the higt test incidence of tumors of the luna. A study on dockyard works] s is also under way. Prelirainarv findincs among this group indical e: "Ndsiqnifleant difference in the incidence (9.4%) of tumors of ;he lung was seen between forkers with continuous and intermittt rnt exposure to asbestos." PROCEEDINGS Tntarnat. Conf. Pnaumocetn Los is. nn. ____________ 1 published 1970. MTV ^ UNIU CT ICOiTIV if ________ ~ -r _______________________________________________ _:_______________________________________ S OCWMMf f]Ml ' Vi*liani. E.C.; Ghezzi. I.: Maranzan cocvaof a*. 3091 hOUTVI CT COM kcv woo o* CMAVAcnvimc SCOPV OTU 36 Epidemiological Study of asbestos 38 workers in Northern Italv. 60 La Mart, riel lavnrn 59 (8-91:481-485. 43 Auk.Sept. 19C 8 61 _Si 63 31 70 85 SUMMARY Dunn* tlM period l*4-t*T. 211 workers CO* men itd 7* womenk coinpmuMd by the INAlt for *biPs. <1ic4 i WcUmom, Liguria ami Ihmibardy. Trwtf two worfcm had been cnpgcd in atbntot miftift*. 1*1 mamifaeturct (MbcttoyuiuW. brake aod friction prodwctu 60 iho production of aibcutH-ccmcrn. and )J m insulation worts. Out of tho Ul dead workers. 21 U0 \) dwd from a lu*$ or from a metothcliomp of the pleura. M from neoplesias ai other sites. *1 from cardiorespiratory disease complicatini nbcitosit. 72 from tuberculosiv II from other causes; in 21 catet the death cause could not be determined. In }4 catea the autopsy vaa performed; among ibeae cases. lung and pleura tumours conttituied the 2) The percentage of lung tumours among the male aibntottci wet approainutcly twice diet obierved among the inhabitant! of Milan. Turin and Peru, and approumately* i I timet higher than that of silicotic patients who died in the same period. Among the )2 miners. who had been eiposed only to chrysolite, the incidence o^lung thmours resulted to bo J.l lower than that observed among other catcgons Of alontor' workers (tcatile and friettoo products, atbestoi-cement) and among the ttflulaiort. ALV 0010S8T Ilk'll MCvataf Mill sir COOS 70 60 61 ill 11 42 85 s(r noap on cnaeaCTtetgTie Epidemiological Study of Asbestos War kers in Northern Italy. !.rfnre 4 97 -2nd Tntepnarinna^Oanf. Biological Effects Asbestos. Dresden. April 196$ Proceedings published 1973. pp. 147-3 *0 tKaalal at 2934 Kon nor OiTt A. uilbfan riTLI ihMICI f - <0lTCt If Zanardi, S., Lerza, P. 6 Russo, L.: oocuiscmf &oc or 3838 VOCATlOS 10 Clinical and radiological problems 11 concerning asbestos is (Italian) 12 (Problem! di elinica radiologia del .'asbestosi) 30 La Medicina del Lavoro, 63 (7-8):257 268, July-Aug. 1972 31 33 (English abs PVP) 36 38 37 | One of the <noa icriuu, problemo conaming iibnioin is certainly that o< early T:------ clinical and radiological diagnosis. The Authors therefore aim to bring a contribution 0r to tbt tuhrrct by reporting and diacuaaing the acmciological findinp obtained in no- 7 n | meroue cam of relatively early uboutn (700 cam o( aabettotia al first observsuon ---------- - found among almoM MOO workers of the naval induairyla Tbo clinical upsets cono- O 9 1 dared include tubrecave symptom, physical signs. chest X-ray finding*, (uncueaal and ~~~~ laboratory findings. Moreover, the availability ot a second group n( patients followd-up _______ lor a long lime |70 atbestous patients alive and periodically controlled for 90 to II years), as vmU a if a third group ot dead asbestoses cam Ol cam controlled at ----------- autopsy) enable the Authors lo bring a further contribution to the knowledge ot the _______ : clinical course and prognom ot this pneumoconiosis, both in its typiol evolution and i in the evolution modified by the venous complication. i X fails* ......................... . u -i. ... IN0CX/TRACING CAPO 40 \ *"* \ .................. mu iMItll <*! IT - net " or 3866 aacuatar titkl ft COPC Zannini, D.. Bosetti r B- 6 0ttenga,~F.: I CWAfCTtmiTIC icon orct Tht risk and prevention of aabtstosi in shipyard works (Italian) _UL (II riaehio m la pravenziona dll' 12 *sbstosi nell* lavorazioni navali) 30 La Mcdicina dal Lavoro. 63 (5-6): 31 221-244, 1972 36 36 t:__ ika Am (* reporta of cite! of aabcwoaia amoo* worker* cn*a*d m mew 63 Ulaoo iobt by imui of ilboui aboard thipe in buikfcn* of repair. the V* moconiout in luch worker* hat revealed to far mart and mot* u*trt. and baa in 70 yoivtd alto other eroupa l -orkert of ihi naval induatry. in whom, in the Ian <- 85 Bloural of pulmonary Icaion* arc found mor and more frequently. Of no minor coo* SJTia Uw.nereatmf fluency of pleural or pulmonary lumouft among the aamo Sorkeri. The aetual dilfution of tuck diwatc* can b< rtlaud not only to a more ay* ticmalie madkal checkup of lha worker*. but alto to the moffand mora inicnuvauao of atbaaloo in lha law yearv In fact atbcwua it uaad aboard not only for ilia maw lSaiiIoTnboyf icniiin.cto. fbuta*livo faonrd lhbay ihrperramyi.e Aalnmdoaocuawllkpmeoapulleauwonurokfina.Hath^irpUwthruieptuarvma. buildin* and repair arc therefore evpoted to iba inhalation of atbeiun. at it * been damonwraiad alio by lha catca tiudiad al the Inaiuuu of Occupational Medicine Canon, and by the conimetric Amlin**. It ia therefore required a rcaoluie urtanmaltoo of lha prevenuva mcaturev which conaiw both in tubwiiuun* aabcatoa with other mn* larialn and ia reducin* iba amNent dutimcta. in own* individual protection mentor** for the worker* directly or indirectly caponed 10 lha riah. in or|amtin* the work aboard, in inwructin* lha peraonitrt. in wudyin* the ambieat duwinaan. tCTMlQ'M . (* >1.MM i i 8 I INOCX, TRACING CARO ALV 0010889 PROJECT No. 6 - 43 I Project No. 6 ... The cellular basis of the biological effects of asbestos Study of morphological and biochemical changes of macrophages and fibroblasts cultured in vitro in the presence of well defined particles of asbestos, such as: chrysotile, amosite, crocidolite, anthophyllite, tri dimite, and in each of them long fibres and very finely divided particles separately. Whenever indicated the in vitro experiments to be expanded by suitable studies on experimental animals. > Cost: $45,000. Or. Benvenuto Pernis, M.D., University degli studi di Genova, Via Balbi 5. Genoa, Italy. I (Continues as IOEH #17) ALV 0010951 ! ( MIC itiHItl * 1 * If adgaAf TlVVS g. Govern*, M. 6 Pemis, 8.: --| IP6< " OP MCvaial m - 386? kOUTiN ut'com 20 25 27 120 36 6 9. tr *0*0 0 CMiauTCaimc Bioloeical effects of asbestos (It) (Azioni biolo*iche dell'amianto)______ La Medicine del lavoro, 63 (5-6): 161-178. 197? KOPf NOTH (English aos. pvp) 72 73 85 tdUk oocuB^vmi IRNKI tf ]! IV 1 Govern*, M. 6 Rosanda, C.: MM 21 A histochemical study of the asbestos - 20 bodv coatin*. as .T Tnrfua-er. Med. 29 (2): 154-15 i. 1972 """ft ft OP kocano* Cow*. M. aad Roseada. C (IfTJV mu J. imfustr. Mt4.. . IJ4-IJ*. A Mrtnrtilnl rtudr sf *w >tO>Maa hod? eaedf. Aitem bodice after iron extraction owe taatad br histochcmical methods for mucopolysaccharides. The results of tha reactions tuignt that add mucopolysaccharides an praatM ia the coating of moat bodies. During theformarion of tha bodiesacid mucopolysaccharides might act as a maths for iron deposition oa tha :------------------------------- ------------ l i X fuw eiiHi (9'" 0 . IKOIX, TBACIHO CABO - 47 -- . - --- ALV 0010392 (*10 It OOCwlJ^lfU Govama. H. 6 Rosanda, C.: OOCwi*r m* PkCl or 3863 MT COOC 21 *tv 0*0 00 cuacacttoitric The mechanism of formation of ?ms! t i a1!-fJi-rfi 72 asbestos bodies (Italian) 85 ------- . (Meecanismo di formazione dei corpuscoli dell* asbesto) La Medicina del Lavoro, 63 (5-6): 179-188, 1912. -HtfUV r ? i I a "I si till- rli UlfM:1?! -- Is *4s f r*From lb results of ilx must recent tludiea on the mechanism of formation of -- JT f Ii *t i ^ asbestos Mm. it mm that on* can conclude, according (I96H that ashrstos bt>di<t arc the terminal product of a to Suntt and biological proem CmhuiceOh occurt in the macrophage. which hat phagocytotcd a mineral liter' within ;aa 'V- ----- lysosomc the (iter would te covered with the coating of organic substances. tar? to tbit report, ihc results are presented of a tenet of etpenmental studies. from which it it poitihle to propose an alternative mechanitm uf attetiot hodiet formation. >y an m him etpenment in an acellular system. prcviout observations have bevn ___ confirmed, according to which the formation ofattettot bodict it potublc without th. -- active intervention of cellt: in fact, atbettot bodict have been oburned by incubating chryto'iile litert in sterile taline tolution containing albumin, hyaluronic acid and femun. y hisiochcnucel uudiet on the coaling of human atbettot hodiet. n hat been moourated that the inner layer it composed by protcint mued with haematoidin and ___ feme iron: above this, there it hyaluronic add. finally covered by an outer layer containing ferric iron. Hittochcmical studies on the substances which deposit themselves on the asbestos present in espenmenial granulemau from carrageenan, have demonstrated the high afRniiy of atbettot for haematoidinS hyaluronic add and iron. In fad. already in the initial phases of granulation tissue formation, all these substances had ttraulied them selves on atbettot IIben. These were coated, even though they were free in the tissue iUHh ground substance. and were not phagocytoted within the macrophages. Hyaluronic acid a a phyaological cuncellular component of Ihc gound substance |Hf* MU1> OOCumTbtIiTU SIT COOC ji. ifiMKI IT I0(TC0 It ik mm Governa. M. & Vadala. C. Rosanda: mt wood on cwanacTtnitTic Histochemical demonstration of hema :oidin in the innermost layers of human asbestos body coating. Int. Arch. Arbeltamed- 30 (4): 273->82, 1972 MtWKt * or 3785 isOCarioa scoot norts .faeasry. The veU-hnowa hietochrmicol reactivity of aabevtue bodice hac been modified hr tientmcnS with inn extracting Mutes* and eturmra. .titeesos hodin did nos exhibit any more 1`nuwian blur pantirny after treatment with iron extract, ing solution*, but sitoami a loluidinr blua mrtarhromaaic due to hyitliuonir aaad. The tanw boslirv. treated lirfore with inn removing solution* and digested with tamieular hyalnrotndase. wrrr not lolualine lilne nsetavhiomatir. but exhibited again a Peris positivity. Tlicti these tame hodirs bee*me again l'erl* negative after a second iron retraction, and shoved instead a positive liematoxlin reaction. Tho diameter nf the same body appeared propmsively smaller after rarh treatment. Moreover the hematoidin |*utiv layer hail been to digested by trypvin that atlwatos theca were ar lea*t 0|dieally naked. * `' "" Thaar findings snggret that during the desrtepment of ailiettoa body mating. (ret ptotrin*. hematoidin and feme iron are depoaitrd over atbevtua fiber* r-*ub-.- acqucnti* hrshirooK arid i* laid around I Ik Bret layer, and finally other feme iron particle* impregnate tho hyaluronie seal nulrcnlr*. ~ - 48 - I ALV 00109S3 |ieM8l If C*ftf oevauf fiTvc Govern*, M. 6 Vadali Rosanda: net tr com 43 24 ____________ CT WQMB QA CWtKMTHHTIt Histochemical study of asoestos tiDi coating in experimental carrageemn 28 granulomas TT British J. Industr. Med.. 30 (3); 2*> 8-252, 1973 85 BCvMat # or 3869 tOC*r* Kon <orci To study Hit composition of asbestos body coating. nbnioi partivtct prtsant in cxpnrimanul eomteonin granulomas wort tested htstochemically for mucopolysaccharides. ferric and ferrous iron, haemoglobin. end haettiaioidin. The steins ere applied on microicopicaJ sections both untreated and treated with iron-extracuns solutions and/or -rntymes TV results indicate that asbestos is rapidly coated with hacmatoidin. ferric .iron. a> . hyaluronic acid. IMCUUUI an. race JL 3140 K i Parazzl. Elen*; Pernis, B. ; Secchi, G.C. 6 Vigliani, E.C.: IT COM it none on CManxcTtaiinc kon worn 43 Studies on 'in vitro' cytotoxicity Also in Proceedings Internet. 44 of asbestos dusts. Conf. on Biological Effects 72 La Medicine del Lavoro. 59 (10); 563 - of Asbestos. Dresden, 8 576, Oct. 1968. Aoril 1968. oublished 1973 as pp. 74-81 The cytotoxic action of different I*pet of atbenot dusts on lutnea p<| phases cultured in vitro was studied. This was done throufh invettifatioa of. the production of lactic acid, the lost of fluorochromawa. and the release into the ' culture medium of cniymes belonging 10 different intracellular structures -- cytoplasms and lysosomes - from macrophages cultured in vitro a ind treated with chrysolite ' and crocidolile dusts. The results obtained utinf the three methods listed show that' both types of asbestos possess a marked cytotoxic action for. macropha|tt: this action . is evidenced by a reduced production of lactic acid in the treated cultures, by a rapid loss of fluorochromatu in the cells, and by a marked release in the culture medium * of lactate dehydrogenase. which is an enzyme belonging to the cyioplasmatic fraction . of the cells. Crocidolile exerts s more marked cytotoxic action than chrysolite and an even greater action than a tridymie dust used as a comparison. Experiments made using separately ihc particulate and Abrous fractions of the two above mentioned types of ashcsius thowed a high toaicity of the llbrous fraction and ' a moderate damaging action of Ihc particulate fraction: the different toxiaties for . the macrophages of the two types of albeitos used in this investigation might therefore be attributed to a greater richness in fibres of the crocidolile or to some properties. of these fibres. Pre-treatment of the asbestos dusts with PVPNO or EOTA did nos reduce the cytotosic action: the authors ara therefore inclined to believe that the' cytotoxic action is connected with the physical characteristics of the dusts rather than with the chemical characteristics. BIII-2,June 1969 mw M'i0iw aiau !(- ..INDCX/TBAONG CAP - 49 -- ALV 0010SS4 T coot 120 40 72 85 91 Mill II IMHI If CT aoaa oa CMsasCTcaiSTic Studies on the Cytotoxic Action of Silica Dusts on Maeroohages in Vitrc Arch Environ Health 17 (6):8S0-8S9, Dec. 1968 PkCl . - or MCvaiaf M 3087 Vigil*ni. E. JWt KOMI Summary Experiments were performed in order to investigate the sit's of cellular damage in* duced by silica ifcirticlcs in vitro to peritone al guinea pig nuirrophugca. The release into tire culture medium of cell sap enzymes, lactate and aldolase, and of the detiydrvgenuee lyvoeorvd cnxymea. ae.d phoaph.-tl.ve and rfloiuelea.w. a indicators of losiona Fo didrrenl cellular IrueUircs, was followed. Low of fluocochrcmasia (mm cells, as evidence ct damage to the cellular mem brane, was also studied; with tliia method it is possible to elucidate tha early modi fication of macrapHapca treated with silica particles. Whan tha interaction between quarts ac tive group* and tite cellular membrana waa prevented by coating the particles with se rum, a delayed release of cnxymea wax ob- IITMI IW fN* *> TTww olrcrvulions suggest that when sill* cn is added to mecrophige cultures in vitro, it interacts with the external cellular mem brane and that tha ftret cellular lesion occurs at this sits. Further damage might then be inflicted by the liberation of lysosomal en zymes. IMOCX,TftaCING CAKO ALV 0010955 f ocwaiaf n 3S87 tv com 43 44 72 8 8$ 74 Pernis, B. ( Castano, P.: (t oe on CH**cuime The effect of asbestos on cells m vj tro lit). (Effetto dell*asbesto sulle cellule * in vitro). Medicina del Lavoro. 62 (8-9): 120-1; 9. Feb. March. 1971. \con moth (English abstract PVP) 4jsaa.`a 'tsw'as Si agaugg-^s?^ rrsawu'tKtT.*"f'-TMS""35 ffljjSrS SSiT**!t-.< *"" ... ~* * -- Ml fernetiM It MUAr 4W*4 ---------- ere acvMCtr rirvt ntutt tf (8>u 8 MCI *IT coot 72 43 44 45 48 40 IT *0*0 O* CTUIUCTIItfTIC In Vitro and In Vivo Studies on the Efects of Asbestos Fibres on Macro- pha jm*. Lecture I17-2nd Internet. Conf. Bio. Effects Asbestos. Dresden, Aoril 196 8 17(1 85 i , OOCUtt M OP 2981 lOCanoa icon notci i i *^ - ** ji - 51 - fHLV 00103% PROJECT No. 7 ALV 001039? Project No. 7 Anthophyllite asbestosis in Finhand OBJECTIVES : 1. Clinical picture of anthophyllite asbestosis (fibrosis of the lungs) to be investigated in a cohort of past and present workers of Finnish anthophyllite mines and mills. Differences from the classical asbestosis in radiological picture, speed of development, frequency of simultaneous findings of pulmonary fibrosis with pleural plaques, cause of death, etc. to be explored. 2. Prevalence of pleural plaques and calcifications in the general population to be investigated in correla* tion with the environmental conditions. 3. Prevalence of all signs of asbestos exposure to be investigated in a cohort of construction workers. Cost: $42,000. \ Dr. Leo Noro, M.D., Institute of Occupational Health; Haartmaninkatu 1, Helsinki 25. Finland. ALV 0010SS8 net" t,fWt *Ahlman, K.: car coot (r eoeo O* CMaaaCTtaisriC UO Industrial ulmonarv disease in Finl and. S'* Scand. J. Reso. Diseases (Supol.) 63 : 101-104. 0* 1968. MCvilsr 3779 wftCAfim 1 1 ssiar isnui iv MUattl^ni 11*711 1? rao* KIT COOC 65 70 10 Tfl 41 2 - "T3 CT00 on CManacTtnitrie Work-Environment-Health, 8 (uu summary) (l):l-5, 1971. Mcwviar a. or VOCiiVslOn** f~l SCO* ftOTtl 45 48 84 0*7( iocwsi? nru Mr COOC 48 60 70 10 84 10*7(1 IV Ahlman. K.: Partanen. T.J.: Rintala *(y woto oft CMAftAcriftisTic Anthoohvllite mining and milling as a cause of asbestosis Biological Effects of Asbestos IARC Scientific Publications No. 8 (IARC - Lvon. France. October 1972) oo. 165-168 lOCiisiaf aft. f*6( or 4226 IOCAT** E.; Wiikeri. M.: . KOftfWOTU SUMMARY Clinical and rptdemiological dan concerning occupa* lional capotun to anthophyllna atbastot an nponad. The data Mm it a cohort o( 1249 individuals with exposun at an anthophyllita nuna and null tinea 19*J, 105 of whom an known catat of ubntaata. Raaulu and the prognst of different phana of tha project an illuttntad and dimmed. A ptetun of a danparaua working vironmant ante^ with heavy haalth nskt, aapanally for wertan with te&laudTc - 57 -- ALV 001093S * COM JU. 76 yjTjOCU* It Ct Laamanen, Arvo: time The use of snow samples in air pollution studies.____________________________________ Work-Environment-Health 5 (1):42-S0t 1968. [it mir intv.iijjiinn of sir pollution in Fin* laud tc luve nfiMitt'l tlie distribution of different impurities in the environment of otne point ami area source* by primarily u.iug tlw * sampling mith%>l. Tlx mow sampling m-tlmd L* easily applicable in esti mating l<-1m>-<r levels ami i especially useful in spar.-ly |H>puLt-l area*, although we have Jcmmi.trated that, umler circumstance* where tiff arr similar eritrria for evaluation, we can at... n-v tin- itftlnel that we luve developed in dm-*Iv populated areas as well. MCuwlar ae. JL 3106 KOfl eortl n coot 1 8 56 60 48 84 ^L Maiwiiviii rv* vwi KCT WOOD 0* CMAftACTtmVrtC score noth chloride, sulohate. and nitrate con :entrations in drinking water in the surroundin [S of an asbestos auarrv. Resort from the Institute of Occuoa rional Health. (Helsinki) No. 72: 5 oases. 1 fie.. 7 tables. larch 1972. fflGo n t UJudL* 'lc /& 1 , irmiu it (ru tt OCwBCftjTifU Laamanen, Arvo: KCV cooc xrr vooo or CNARAcrtmcne 6 Reoorts from the Institute of Occuoal ft Health. Helsinki. Finland. 84 No. 72: 5 paops. 1 fie.. 8 tables. Ma reh 1972 ------- OOCUMCMT eo. or 162 tOCATioa score Horn t>o. T i -- - t ALV 0011000 36 Tr 48 70 84 60 ItsMUl ' If * Heurman, L. 6 Kiviluoto, R.: line -- HCt - Of OOCveuf e# iota'2**947 icon xotu Retrospective prospective study of anthophvllite asbestos workers in Finland. Lecture >34-2nd Int. Conf. Bio. Effects of Asbestost Dresden, April 1968 '"ceed ines The mortality from all causes of Finnish asbestos' miners is briefly discussed. JuMished 1971 rp7"135-13 8 I Similar paper presented at Intemati onal Conf. on Pneumoconiosis,Johannesburg, S.A. Ap ril~May/69, This very brief paper presents refined data similar to that presented by the same' authors at Dresden in 1968. The mortality rate from lung cancer is 3-5 times higher than the expected, but the authors pointedly note that incidence of 61 cancer is normal and there were no cases of mesothelioma. in 1970. *1 Wf MINUI ft UtTII II OPCUMCaT Tint Koro, Leo; tT COM KIT *O0 OO CMAOACTtmtnC ----- 7T Occupational and "Non-occupational" --r Asbestosis in Finland. 3 Amer. Industrial Hygiene Assoc. J. VLto 79? 195-701, Mav-.Tune 1968 \ 33// & aoevaut *. MOC Of LO2C8tr8to7s ICOfC MOTft '\ 10 kh - ALV 0011001 iMill ('II IT MtviMaf ti!U IT coot oro L. ue -10- nf Achxtnc - Belafe/4 Pi tlt 10 ______Presented f TnTm 36___ Congress on Oeeup. Hlth. Tokyo. Scot. 191238 Proceedings published 1971a. pp. 207- ?09. 84 M(vur n121L. KOI nerd In some thousands of operations and jobs the workers are exposed to asbestos 'dust Facts concerning the health effects in the mining and asbestos industries are well known, but other occupational groups have not yet been studied enough. Improved dust control has diminished the oumber o( classical asbestosis cases, but the late results, such as malignant tumors, have entered into the focus of research. Smoking, the increasing amount of air pollutants, and other potential environmental carcinogenic agents, however, complicate epidemiological studies ^mepg workers and the general population exposed to small amounts of asbestos. gofgiCf img *Noro, Lao, Ahlman, Kaj ; Laamanen, Arvo t Viktri, M. KIT COM kit woo on cmjucrtmtn* Aabnatoan ala Berufakrankheit in KOPt MOTH Arehlv fur Gewarbeoathologio un|l Gnwtrbnhygienn 22: 179*184 , 1966. /j % 3k=: j Zuuinmrntaaannp Die Produktion von Anthophyllit-Anbeat in Finnland lw*t gnren. wirtig bei 190001 im Jshr. Mrhr l* 1200 Arhriter aind lieruflirh Abra. stsub auageaetxt. Zusitilirh ta techniaeher Stanbverhittnng ainu-in den Ictxtcn 10 Jahren veretirkt msdixiniache Arbritsuntrreurhungcn ilurrhgcffihrt wosrlen end ungefihr 4000 RAntgenaulnahmen in Vcrbimlung mit perioriiachea Untereuehungm grfertigt worden. Bis jetxt tvurden 1S9 AabestoseflUle im Verlaule rnn 30 Jahren diignostixiert. 14S ilavnn in tier Aabeetinduatrie unrl 39 unter lanlierem. In Her Asbeatinduatrr leg tiie Zeit, die die Arbeitrr drm Aahestataab aiigectxt waren. W Kilim twiachen t untl 19 Jahren nntl in 49 Fillen bei tveniger 11 Jahren. In tiff suletst rrw&hnten Bvechiftignng arbeitrten 8 IV aonen linger ala 39 Jahre. iihnc Pneumoknnioa* xn bekommen. 3ie Situation lordcrt mrhr Aulmerkaamkrit in hrxug auf die trrhniaehe untl metlixiniaehe Knntrollr in Aaliesfwrrkrn. t - ao -- ALV 0011002  .0811(1 #f !!>( If tCtfVtaf Tifvl * Mss. IT COM L#o. Ahlman- Rint^la and al: IT WOOD e CN4CTIHTH ii 48 aidemiology of afrthophyUite asbesto; is "T7 areli^ary results. (1967) ra 4+ on Lecture Dresden Conference - Proceed:ngs 11 published 1973. pp. 130-135 rear ' ocviuat m. or 2726 UCATWa KOI aOTgg * The Institute af Occupational Seelth haa utU now eelleeted la Nalu4 144 aaaaa of eoleeteoie la tha aabaatea Industry - Inoulatara excluded. Industrial hygiene atuiloa from raaaat years thorn that tha dust azpoaura haa baaa rathar heavy la aoaa jobo, sspeoially la tha quarry aad ill. but tha altuatlaa la lapreeiag. hirlni the last 30 pain approx. 3S0 workers haro baaa exposed to anthophyilite aabaatea la tha quarry aad alll during bora thaa ana year. Oaa half af thla (roup haa dial, aabaataala haa baaa dla^oaed la 1/4. ill present aerhara aad >4 ratlrad workers (total 135) hara baaa studied roentgenologleally aad clinically? la 37 aaaaa, of ahioh 13 on now, X-ray ehaacoa ladleatlac occupational aaboatoala have baaa fouad, IS being la atago 0 - I, 13 la X, 3 la XZ aad 3 la XXX, la the aaboatoala eases tha ago, azpoaura, history of sacking, pneuaoconloels, produettea af phlega. ahortnasa af breath aad abnormal lung fuaetloa toata ware elgaiflcally greater thaa la tha aoh-esbeatosla group. Coaparlag tha aelf-reported eyaptoas (phlega aad shortaasa af breath) with tha ordinary aala rural pepulatlea aad luaberjaeks at tha same ago, thaaa syeptoaa ware aore frequent laoig workers azposad to aabaatea dust. The study la eeatlaulag with aore detailed X-ray aad ultrasoals achograph aad other ezaalnatlaaa. ikMIll IT mm ? i MGC ------------------------ M(UITT *0 Qf 3789 turminen. Merkku: *V COM it wood oa CHaaacTtatiTtc 1 icon xorts 36 57 36 42 46___ A study of the mortality of workers 1 in an anthoohvllite asbestos factorij in Finland. . j __ Work-Environment-Heelth. 9: 112-118J 1972 T 60 ffunwiaea, M. Work-CWTireom kith CliTH lit--lit. A itudp of (he mortality of jn uiarhere la aw ealhephyfllta etbcilae factory * fluleed. A cohort study of ION ---- workers employed at an anthophjrllite aibaetos mining factory 11 described. It extends 84 tha Information about asbestos related diiceie at this factory which was previously " available only for workers with severe exposure. The cohort wss defined as ________ tha workers with a minimum exposure of three months who had starts! employ* ment at any tuna between IIM and ISM and the main analysis wss of mortality i up to the end of IMS. The hsiards of exposure to anthophylllte asbestos dust ire indicated by tha main results of this mortality study: 1. The cohort of workers 1 wee found to havo excess overall mortality accounted for by cancer of the lung, _____ broachus and trachea, respiratory tuberculosis, and other respiratory diseases. L Asbesteeii las an underlying or contributing cause) was mentioned on the'death . certificate af every fifth decveied member of the cohort. 1 Tha mortality from lung cancer among anthophyUlta asbestos workers with a minimum exposure of ------------ three months was la certain tga groups over three limes that expected. -------- _____ -----------____ -- ------ ALV 0011003 |l| ItiMtll II MCbdMI fiKC * Siltanen, Eero: J j ____________________________-________ Inct MCvxat m. -___2____ 2957 biutw* Kte coot 3 04 *lv woao oa cnsascrtaitTtc Measurement of asbestos dust. Nordisk Arbeidsmedlsinsk Mdte Fagernes iS - 30.11.1S68 (pp. Pa. 1-2) Kon worn - 1 1 MTI liaMift tf * L* MCUaiWf fiTVt ' *Siltanen* Eero: |t?C it 1 s.o I Ipacc ate coot 3 43 44 45 45 60 kcv woao oa CMsascrcaitTiC Comoarison of asbestos dust measurei tents bv countin* oarticle and mast coneei itrations and mass concentrations with differ* int methods (Ger.) Verglwlrh winigwr Mwthftdnn tur M***i in - 61 62 76 (English abstract H. Bohlie 6 P.V. Pelnar) BU OOC*M*T a* or lO3C44T0*9 Kon worn AT* KCV COM 2S 29 40 CM* If (fiTCI If Taskinen, Eero, Ah1men, Kaj 6 Wiikerl, Matti: oocuwtaf n. or 3885 t9C4T cv *oo a* CKAKACTimtnc | Current hypothesis of the lymphatic scon worn transport of inspired dust to ths parietal pleura. Chest. 64 (2): 193-196. Auk. 1973 1 la iba tlgbt af a cm npait will tacrlbi hypothesis of lit* hnptaik tranrpoct airchaabm ot iahaied dust particle* to the parietal pleura. The autopsy *f a moIdee who had beta employed far 41 yean ia Iron foundries thawed heavy mixed-dost pneumoconiosis. la the parietal pleura there were bbcb linear ttrtaka following the rouna of Intercostal arteries. These formations wars microscope tally Interpreted as periarterial lymphangitis and Rbresit caused by the dust. According la our hypothesis, the dust psrtkk, have been transported from the hangs via the lymphatic vessels partly in retrogression. The mechanbm t* iu^ paasd la be the same la the transport of smal asbestos particles causing plearai' h'M--- . 3. ALV 0011004 N(a|af MTV* it cooc 30 31 76 72 12 MCI ViikerijjJ^: *t e*o on cwraacTtanrn Ultrasound Examination of Pleural Plaques: experimental, pathologic and clinical studies. Supplement 301 to Acta Radiologica. 62pp.. Discussion of Mav 1970, Helsinki. Circulated; front page and Pages 55 aad.iS. mtar i 1H< teort MOTM OCWHttf KIT COM o TT -3JL 31 tr TT 64 TT MCI Viikcri, M., Jaaskslainen, J. S Tahtia: kct wooo on ounACTfiync Ultrasonic Examination of Pleural TMrVning and Pa 1 r > f i cat i nna in Occupational Asbestosia Pis. Chest, 54(1): 17-20 , July 1969 -22- OCtfMiaT 3031 scoot norcs Tbn ronntstaologk dlagnodn of oeeopailooal 4 baatd apon typb. cai pohnaaary Itmb a4 anteriorly detected plearal ctldiaiiM^ wUA appear ancb birr tbaa parenchymal changes. Therefoet, a Wait* dlagnoela ----"y demanda a Jong ober*tlon period. W* uttd iillrwoak A- aad * ' ade mikoda te tiamina pkaral ehangne le ala* aeeapartoaal aabteoik partanti and Im normal penoim. la normal paraona tbn parietal plaara waa dua m a Ihla. ihtrp Una whna lHa B-moda matHod of ntamiaatioa waa mad. RaaatgaMgraphkaOjr obacrvad cikiBeationa wata taiUy datectad aad dlaate- laiabad from the normal plaara bp tbla nomination. It la noteworthy that limb lar echo paaka wart an In A-aoda axamlnailoai In Intatal and poattriat plaara. wbara roaatgtaograma did not reveal plaaral cakibcatioaa. aad tbalr dia coaid bo mead ml with iba Bnnoda examination. Tbaa b la pomlMt to ad aniijr plane* cbingaa. which, la oar opinIon. art coaaactad wltb ectapa. canid bn aaada earlier wltboet a loaf obetrradee Art IMHI If OOCWMWf TITU * Viikeri, M.; Jaaskelainen, J. S Tahti, E. KCT COM 12 30 31 ~TS~ 84 kct oo ot CHAiucTcoimc Ultrasonic examination in Occupational Asbestosis. Scand. J. clin. Lab. Invest. 21, Suppl. 101, 105, 1958 oocyar o or 3036 scon notci ALV 0011005 lt (OM -12- 30 31 76 84 j^ikerijJl^jSaskel^inef^^J^S^Tahti^E^ t oo n {h*ctihtic Earlv detection of pleural thickenings and calcifications determined by ultra sound. Work-Environment-Health S <1);68--72 1968 -------- SI M\l MC\ " IV lluirji'V o all of ti-n |utii>nl ------ a< ruitiiwil bv ullrjMHin* A* anl D-iiHuIr r\jiiiiii::tinii. | l||rrl"i^' ill** f |'l'-tirjl rjk irH-jlion- sit*l lluVkriiitiiS*. R<riti> Crtu><*rj|>lii>-ally ol-orti-il >-rc -- fniiii.l in v-vi-ii In tin* ultra'him' ____ rxaiiiiiutinii. .li-liiu t > luiti:'* *i*n* nlwnol at ltu*w |.|a>i t. (n jiUitlixi. pl-iiral iliitbrn* ins* w.-iv r<v*<s'ii.->'il al**i |**trrirly Ix-rr .tlwy lul iml Ufti ni,n in lb** rn'iilp'iH^ntn*. I lira-Hiix f\ain<iuli<xi' flit In fT.-r IxliiM * fir ini|<r<ivliix tin- rjrlv ilusmni* of -- |li-tral . lunr--.. HCvallt m SL. 3089 KSK MTU tNOCX/TRACIHG CARO - ALV 0011006 PROJECT No. 8 - 65 - ALV 001100? I Project No. 8 A study of the health effects related to asbestos exposure in workers of the industry and other residents of New Orleans OBJECTIVES : Phase I: All employees of a Johns-Manville planfand a National Gypsum plant manufacturing asbestoscement goods to be examined by a questionnaire on occupational and respiratory history, by a physical examination, by PA. and two oblique chest X-rays and by spirometry and transfer factor measurements. Additional physiological measurements to be done in those with abnormal clinical or radiological findings. Past employees to be traced and the cause of death to be investigated in those who died. Attempts to be made to assess the past dust exposure and current measurement done in the plants to be utilized. Phase II: Plans for community investigation of risk of malignancy in individuals outside the plants to be prepared during the first year for the later realization. Cost: $291,380 l Or. Hans Weill. M.O. & Or. Morton Ziskind, M.O., Tulane Medical School Section of Pulmonary Oiseases, New Orleans, Louisiana. I (Continues as IOEH #16) ALV 0011008 I'Hl >tr coot 10 7A 157 80 r*MIIA 1 -- l#eft# T Enterline, P.E.; Weill, H.: Asbestosis in asbestos cement worke "S Biological Effects of Asbestos IARC Scientific Publications No. 8 (IARC - Lvon. France. October 1972) oo. 179-183 _ PCC or tOCwafet | 4229 kKstite - - - -- -- SUMMARY The aebeetct cement mduetry eonaumne iIm butt of the wortd'i output of atbcetdc. Worker, in Hue induauy art rtpoied ip tilica end aebaeiee, end they develop both etbcuoM end ulicaM in ntnnben reined to their total dun tipoturc. It it *uunited that radiotnphic ehanpea of 2.1 category or above appear after a total duet capmum of 1000 rnppcf-months. Atbaetoue appean to be taw of a problem in the aabeatoe wee induatiy then id other itbnioe produen iadtwnea. poaetbiy beceuee the former la trowing mote rapidly and iea wort force her had tarn dust eapoeuio. Both chryiotile and trocidoliie atbeatoa an toed, with the latter confined almoai entirely to atbao tea cement pipe. Cement pipe wortan appear to have a peat tic-- ia teepiratoty cancer bet little aebwoeia. whateaa other cement worken have a modeat eiceu in rcapiratory cancer but a conetderable amount of atbeet*. 4H OCWWlflT *ITV4 |MIU IHII 6f _ _- * Waggenspack, Carmel: ________ 92 UOCATtO* KtT COO( 62 76 kit woao on CHiaacTtaitnc A mortality study of former employee: i of two asbestos-cement products menu actunng score notcs 76 companies. 80 Proposal for a doctoral dissertation submitted to Dept. Epidemiology, Tul me Univ.July 1973, 32 pp. % Zrn - 69 - ALV 0011009 Da'I MM* *r (*'(* .. - DOCa<af fK * * Weill. Hans: IT COM 13 76 KtT mono O* CmiCTC*iITIC Pulmonarv function testing in indust 'V. J. Occuo. Medicine, 15 (9): 693-699, AO Sept. 1973. ___ >ummary At 4 levih H the increasing number id demomirattci or potential occupational paired pulmonary (unction should become a (tin ol the health surveillance program in many industries. In order to ' orovide tome entwort to the oucttiont: Whet mutl the pulmonery (unction tett oo end whet will n ten utr mow can we simple spirometry? Wtul additional mm thouId be considered? Who should per* lorm the tettt and with what equipment? Whil wv ihv JJiul)Wvni in imlyiH ind der what circumstances mifht inhalation provocative testing and jevelopmonl d a mobile function unit be contidwed? - OOCtft*t or 3 92 S icon torn in wkiii tv wni jI DOC!* eaot or 3797 MtUMllff tlTLC Weill, H.Waggenapack, C., Bailey, W., Ziskind, M. S posTite KCT cooc 0 40 42 43 44 Ti err wmo ok oufucTfmfnc Radiographic and physiologic patten s amone workers encased in manufacture of asbastos cement oroducts. J. Occud. Med. 15 (3): 248-252. Marc h 1973 icon notu . ___ 13 62 . 70 80 -, ** j *=: ALV 0011010 PROJECT No. 10 ALV 0011011 Project No. 10 Continued epidemiological research relating to the effects of asbestos on man (Continuation of IOEH #1) OBJECTIVES : 1) Cohort Study. Observation of causes of death in the present cohort of workers of asbestos mines . who were born 1891-1920 to be prolonged up to 1972 to see causes of additional about 100 deaths expected until then. 2) Mesothelioma Survey. All cases from Ontario and Quebec which occur until 1973 to be investigated epidemiologically. Additional about 25 cases a year can be expected in these provinces. 3) Clinical Study. Standard examination of chest radiogram, two simple tests of pulmonary func tion (vital capacity and ventilation rate on exercice) and a questionnaire of respiratory symp toms to be introduced and their reliability and their relative efficiency to be evaluated. 4) Etiology of pleural plaques to be investigated by a) case control inquiries, b) chemical and mineralogical examination of plaque material, c) geolo gical studies of mines where the plaques occur, d) review of dust radiograms from population groups also elsewhere in Canada as prompted by the results of the inquiries above. 5) Further Radiological Studies. Development of abnormality in individual workers to be correlated with exposures to fibres with the aim to establish a maximum allowable dust concentration. Dr. J. C. McDonald. M.D., Department of Epidemiology, McGill University, Montreal, Canada ^ Qgst: 5474,700. _" -(Continues-*JOEH #27) ALV 0011012 1(T cooc 13 81 1 *T Becklake, M.R.: --Lfi!----------------------------------------------- --------------------------------- ____________ ________ *OCvaaiat 4204 bRCAf** KORf HOTII Luna function . rnnfermrn on;___________________________ Biological Effects of Asbestos - IARC Scientific Publications No. 8 (IARC - Lvon. France. October 1972) pp. 31-39 i w Pv..-wrfing pnhl i _iaz3_________________________________ I_____________________ SUMMARY _ J>4 biological effect! of atbeiioi capoture on lung function may be menured by a variety of technique! depending on the purpote for when the mcaturtmenu arc to be made. If the purpoie 11 to study an tibettOKtpoted popula tion with a new to defining whether or not a health heard turn, it it appropriate to "neiure VC or 1C alone or topether with RV, and Oun (SB) (traiufcr fac tor). If the purpoie it health-tumoinance, VC 1C or FVC appear to be the moat satisfactory mcasuromonu: al though it it likely (and remaint to be tatted) that tnaanirt menu reflecting the twu of the tmall airwayt wilt be men sensitive to the earlicM effecu of atbettot dutt exposure. - If the purpoie it detcnptrve. ie., to document the patho-phyvoloeical changet which charactchte atbatout in nt vtnout itxpn. any or all of the many available tent for the ttudy of overall or rational king function may be used. If the purpoie it to evaluate the effect of pulmonary malfunction due to atbatoa eapoeuie on the overall function of the individual, a detailed uudy of adaptation to profnaaivety increasing aerate loeda it called for; NU 04X0 If corn ot #g lOOCMMlNT 0. or 1 '*283 BECKLAKE, Margaret R. , FOURNIER-MASSEY, Gisfcle S BjjfdlT Robert: KCT COM ft 13 43 60 70 KCT *OR0 OR CMARACTCRIST1C Luna function profiles in the chrysotile asbestos mines and mills of Quebec. CHEST. 69 (2):303. Feb. 1976 Supplement 4-u 81 SCORf ROTH 0*l iNI(l Ot KOiTCO Of oocvc*r titx OCT cooc 13 70 76 tu * BECKLAKE, Margaret R.: KCT *0*0 OR CMARoCTCRimC Introduction. Bulletin de physio-pathologie resoiratoire. 533-535 , Juillet-Sept MCI 1970. * *OOCvmCM Of 4297 lOC*V0 K0*C ROTCt ------------------------ ALY 0011013 .... MKtll |V (#111 It eecvaca. dru BECKLAKE Maraaret R.i tv coot atr woeo o enanacTtmsTic 90 Asbestos-related diseases of the ei luna and other oraans: their epidemiology and implications for clinical practice. American Review of Respiratory Disease. 114 (11:187-227, 1976. -- 9M or Meeiif e# 4341- ICO'f ROTH (mum utMi inocx. tracing cars Mn HiMil# 11 liiti# If MCVMlt TlTV^ 4 fournier-Massey. Gislle: race w coot KIT WQUO Q OUMCTWITIC _21L 70 43 10 Etude <pidemiologique dans 1*indust pi de l'Amiante dea Cantons de lEst (Fr.) An opirinmifi'lng'irnl__ Study ftf the dStiSStQS industry of the Eastern townships 60 TT L*Union Mldlcale du Canada. 98 (111 At port at an international atudy on th* biological ttftcu ot asbeoee, tfat Deportment at Epidemiology end Health at McGill University la conducting restarch atudy ia lb* nhsiins industry at tbt Eastern Townships. A deeeriptioa ot tbt project b given. That retrospective and prospective study mtmpa to dtfinc the causes ot death and the uate of health o( the worked ia urns of res piratory questionnaire, industrial history, chest radiograph and respiratory function. #OCIdMfMV or 3 3SS 10C1IIM KOn NOTtl ALV 0011014 t 2Enr 1 t ..7 Gibbs, Graham W.: < 4 3717 IT COM Cv^oao oa CHMMCnaiiTic SCO* *OT(t 31 The eoidemlology of oleural calcific it ion. -------- 3-- Doctoral Thesis, McGill University, JO. 208-22W, 1972. 10 --ir~ 36 ------ T7 "W-- u* 6 SO -------51 56 in 81 9 -- m Brief Summary of Results: Reports of oleural calcification from various countries and the role of calcium in tumour formation were-reviewed and dust exoosure indices used for epidemiological studies of Ouebee miners and millers described. Calcified pleural plaaues were essentiallv hydroxyapatite with minor carbonate and probablv formed by a nucleation process. In a studv of Ouebee chrysotile miners and millers, definite pleural calcification was concentrated in men exoosed mainly to rock dust and emoloyed in a small grouo of mines in Thetford Mines. This geoeraohical distribution was discussed in relation to local geology and dust exoosure and the most orobable aetiological agents were talc, mica and breunnerite. Pleural calcification was not due to chest infection or injuries, place of residence or employment in other industries. The mortality of persons with definite calcification was similar to that of other employees of similar birth'date and total dust exoosure and the stuify_ showed no association between definite oleural calcificati'on^and primary malignant mesothelial tumours. ALV 0011015 - -*--*-*--r *cc LACHANCE, Maurice: Dust-Fibre relationships in the Quebec Chrysotile Industry._______ Arch Environ Health, 28(2): 69-71, Feb. 1974. Epidemiological atudlea ol Quebec Chryaotlle iMMti am* nullera haae related miIm mmm ol healtti la dual tap*, aura, aa meaaured a* Via nugget Mi* pmger. Tha Interpretation at tneae rela* banaMpa in lerma ol libar necetaitatoa me eonrertion at midget impinger (par* Vela libar) caunta la membrane nitar (libar) equraaienta. An inveetigation In which IT Ude-by-ilde miagal impingar* mambrana Hilar aamplaa r.tre taken ai Hva mmaa ana mliia ahowed mat ma ear. ralalian wee poor and na aingla eanaar* alan (actor waa (uatilied. Until more dm tailad inlermalian an Via ralaimnaiMpa between midget impingar and mambrana ttnar caunta can ba obtained. It la racornmended mat aalaty atandarda. at taaat in Vila induetry. anauid continue to ba baaad on dual caunta. lor which mere re cenaid* arabia epidemiological auppart. latnar man an libar caunta. lor which marc la na direct aairunca. Matalbl ** or 3918 aeon aoru Af( *0(1(0 0* INOCX THACINS CAPO (it(0 IT 6Xa(M 1iU * GIBBS, Graham W.:. ACT coot KIT *00 O* CMAftACTCftiSTK 90 43 eo ST Chrysotl1e asbestos and environmental health. Lecture at Pacific Northwest International Section of the Air Pollutlor Control Ass'n Meetino. Nov. 21-23,197 i. i MM DOCumUt *0 or drtdfl kOCATea score noth : 1 -- -^ ftLV 0011016 t If !* I* 1 tlfil * Gibbs, G.W.; Du Toiti R.S.J.: 8Kwlt 8 Cf O' 4222 iKiiita atr COO( itt *ono on c*e*cr(*tinc KOH "OTCI 1 Environmental data in mining_________ 60 Conference on: 3 Biological Effects of Asbestos * 43 IARC Scientific Publications No. 8 44 --~~*rs-- 8 56 {IARC - Lvon. France. October 1972) pp. 138-144 in Proceedings ouhlishe i____________________________________ 1973. 81 83 85 88 - - SUMMARY (not provided by luthon) Mining nd milling environment! r probably in* only one, where the effect! ot the venom ubettot Abn type, moy bo Uudied icparaiely. although tapouire n often 10 other material* u well. Companion! on mode between the minini and milling environment* ol atbaato* producer, throughout the world, and the current euiea of duet meuuramena and duu oomrol an dectribed. 04u --A-- OOCwMt^tf7k( ^ M* COOt 70 43 76 60 81 <S0(I(8 * ro<uo Of Liddell, F.D.K.: my woo o CMAURCtmisric Occupational Mortality in Relation to Exposure (Letter to the Editor) Arch. Environ. Health, Vol. 30, No. May 1975 - pp. 266-267 5 net or tOCAYeO* K0M M0TC1 1 i 19 1 -------- ----mg------------------------------------- i -* - ! ALV 001101? |41| Lattte tt itmia t< _______________ ________ ____________________________ *et eecuaiaf tine * McDonald. J.C.: *! COOC in Asbestosis in ehrvsotile mines and 70 mills. 60 Conference onr 43 Biological Effects of Asbestos 61 IARC Scientific Publications No. 8 85 CIARC - Lvon. France. October 1972) 88 pp. 155-159 in Proceedings puhlinhe. 1 1973. ~ ~ or - .i.f.(.44(t3824 SUMMARY The mult* of cpidtmao)ofie*l surveys of chrysolite production uorken in Quebec. Italy and Cyprus appear 10 be reasonably compatible. Information from the USSR. Rhodesia Md South Africa is not at pretent cqmparable, but thsto it nothin! to tuffesi that capenenes m theta countnst it likely to ta baun very different. Tha data therefore teams sufficient to juaufy tha oonciuuon that if tha ntk of clinically ti|nihcant ditaatc it to be kept balo I Vi for a workinf life of SO years, orkert in thit induttry thould not be ecpoxd to dutt concantranom of more than 2 mppef. Funhar ttudiat ate needed to confirm thit animate and-to determine nhether there is any valid fibre equivalent. I 1 uW I'Ml 0|I - --Ml III. al l INDEX. TRACING CARO ALV 0011016 te* HI '"'..ft i w r_ __ 37 38 _60. fbelHb * I a McDonald. J.C. : {v *0*0 O* C***CTt*11TIC Cancer in ehrx/sotile mines anH mil Conference on: Biological Effects of Asbestos IARC Scientific Publications No. 8 _ race * MCVHUT * or 4230 tcorc OTH 81 85 I 88 ; 83 | 180 70 DP. 189-194__ in Proceedings___________ published 1973. _ SUMMARY Evidence for a link between malignant disease and exposure ImH below ibout 200 mppcf-rnra. i... 50 * occupational exposure in the chrysolite producing indus years tt 4 mppcf. Tht Abre equivalent for ihrt Agur* hat try is not strong, despite the fact that mm dying now not bom oubliiM. tnd Quebec beta indent that it were exposed for many yean a much higher dal may be difficult 10 arrive at any unfit convenion factor. concentrations than prevail today. More results would The link with malignant mesothelioma is alto weak and of course be useful, and no doubt research methods can thtro m no evidence of an auocianon with ptriioneal T be improved: nevertheless, the investigation of chrysolite tumours. Chrysotilt-relaicd ttunoun are too few to per miners and millers has been on a larger scale than that of mit any Arm concluuon on tapouire-mpome. The fact T other asbestos workers and gtncrally with much more in- that in Canada there ham bam caeca of mesothelioma i formation on levels of exposure. The results appear to found after occupational and domeatic but not purely show that there is a modest increase in respiratory and neighbourhood eapowre sugpmts that the low duet level! " probably pstro-intestinal cancer in thn industry, most prevailing in mining communities have not boa suflkient - tenous in those who have been heavily closed over long W caua the dream periods. This hazard would probably not be detectable MU Vf T kct eooc 4 13 44 45 81 laNItt at CUO ai MCDONALD J.C. : KCT WOOD OR CMARACTCRICnC Problems In tht determination of safety standards for asbestos* exposed workers. Hefte zur Unfalhellkunde, Heft 126: 603-607. 1976. MCeatiT mO or 4387 L*carM KOPI MOTCS m- -T ftL'v 00U01S "w ITM-:. (tit XKM~y~' McOONALO J.C. & BECKLAKE M.R.: 00(viaf 00 net" or 4386 sKItito It COM 3 8 10 1Z 13 36 38 43 60 70 81 Asbestos-related disease In Canada. Hefte zur Unfa 11hel1kunde. Heft 126: 521-535. 1976. COM NOUS - ___________________________ i________________________________ :_________________ - -40(1(0 ? 10-1(0 l rt,W9 MCI Of ! M"*C'*uDttUt*f ~filUuMcDonald, J. C. ; Becklake, M.R.; Gibbs, G.W. ;-----wM-fcND-on-ald, taD-r 61 K|T COOC 11 12 13 1* 0 2 36 43 69 60 70 81 ct woao 0* cruaacTtaianc The health of chrysotile asbestos AoSSiter. C . Ettfl** norct ; mine and mill workers of Ouebec. Arch Environ Health. 28 (2): 61-68. feb. 1974 TIM raautta at atudtoa at raapiratory a chanaaa. and mortality In ralaiian to dual aipoaura in ma Ouabae enryaatila --~~" taduatry. wMcIt baa amptoyad aema ------------------------------------------- ------------------------- matr implieatiana tar control aiamtoad. raamiaaanaaa on aaarcioo. dimta. and ptaural changaa. and laapuatary dlaaaaa mortality wora raiatad to dual aapm ru -* alma tolalad la dual aipoaura. _ __ Tha avarad aaeaaa at daama tram roa* piralary aaneara. Including thro with mm ----- ....................... abava aapactalton. bnW on aga-apacHIc rata* tar Ouatac and ma mining rogtan. " N aataty atandarda ara tat mar *J'"*d l. ba baaad an apidamiatogical aridanca. dram taaaa data tar ma cnryaotlla produc* - tag taduatry a( Quabac. a raaanabta *- --------j* . ura. baaad ana 1%rtakat acquiring ellrrt- cally algnitleant dtaaaaa. would Ua ' baiwaan I to million paruclaa par cubic ------- . loot, calculatad lor a working lilt oi SO . yaara. In ma abaanea at apidamioiogical bndlnga baaad on llbar ceunla and lack ol a aatlatactory maana at canvanlon. par* beta caunta aheutd eanbnua to ba uaad ALV 0011020 r ' Sm1-" I........... i*to * 46t I*,.,........ 1 MCDONALD, j. Corbett 6 SELIK0FF, I .J. : Of 1276 IT too* 1 fl 60 (T aoao 0 <*>tTfiTic r <r<r artutl des recherces SUT_______ l'amiantose. Des r^sultats parfois kop( tons 80 JKa grnnp nn asbestos-- pi Le Devoir. Mav 31 6 The Gazette.______ T.me ?, 1R7S._____________________ 1 arc mniii it <*rci if |i _n_u_a_n_T__ti_n_t_t ^ 'aoc ! ; UICC Committee (A cooperative study): MCWIRt or KCV cooc K(V *0*0 O* CHAACTtIVT1 KOn HOTCI 1 IS UICC/Cincinnati Classification of j 76 the Radioeraohic Appearances of l Pneumoconioses. SPECIAL REPORT . Chest. 58 (1):57- 67. Julv 1970. SUMMARY ON VERSO |f |{ .... ... . ' J rief Summary of Results: Three interested groups - The UICC Working Party, the U.S., Public Health Service Group of Radiologists, and a McGill [ University epidemiologic group - met in Cincinnati in November 1967. | Agreement was achieved on a proposed new classification which is an extension of the International Labour Organization (ILO) 19-58 scheme. With a well-designed reading sheet, the classification was found easy to < use .by six readers from four countries in 16,000 radiographs from a survey of asbestos miners and mill workers in Quebec. The variation within the | same observers was tested and found to be reasonably small. The variation ! between observers was tested in a study of 100 radiographs read by 12 readers from six countries. The results indicate that the classification should be satisfactory for many epidemiologic purposes. The classification is known as the UICC/Cincinnati Classification of the Radiographic Appearances of Pneumoconioses. | D III, i_______________________________________________ cetiee attic' ! > INDEX TRACIN'! CARO ^ - 83 - ALV 0011021 aMIII M |T(| If U*6C O'___ Cdtf AM ~ - kKiliM WHITE Franklin M.M.. SWIFT, Joanna ( BECKLAKE, Margar4t R.: IT COOC 10 Rheumatic eomolaints and pulmonarv 12 34 in the mines and mills of Ouibec. in 43 60 JJL Bl" rdn- Medical Ass'n Journal. Ill: fRl* R71- Rept. 71 14 74. Summary: in 1M7-M an aaa-lttifiad random aampla at IMS cwrant watfcara in Quabae aabaataa minaa and mifla waa aurvayad. Qwaationa eoneamwg itiaunaM complanta ware ineludad in a modiRad MHC ouaationnara uaad at dwt dma. and an thia baaia a mawnatie aavanty radiant waa daaiaad. No raUtianahip aautd ba dataeiad batwaan mawnatic campiainu and pubnanary ndwtoata raaponsa ta cfvyaatiia dual aapoatra. daapita anplieabona in tfta Rtaratura mat aweR a rotationahip mrfht aval lll.'H H *W a J > t T T NOex TRACING CARO - 84 - ALV 0011022 PROJECT No. 11 - 85 Project No. 11 A chemical and mineralogical study of insulation material OBJECTIVES: a) The natura of the insulation matarial usad now and in tha past in Canada and in tha U.S. to ba invastigatad and samplas to ba examined for minaralogical and chamical composition. b) Samplas of insulation matarial from old boilars and heating systems to ba obtained and axaminad for minaralogical and chamical composition. Changes to ba sought between a) and b). Cost: $52,000. Dr. Graham W. Gibbs, Ph. D,, Department of Epidemiology and Health, McGill University, Montreal, Canada. ALV 0011024 PROJECT No. 12 ALV 0011025 Project No. 12 Identification and quantitation of fibrous dust and ferruginous bodies in lungs of autopsied adults OBJECTIVES : Lungs to be obtained from autopsies of persons: 1) not occupationally exposed to asbestos whose life has been spent chiefly in urban areas, 2) not occupationally exposed to asbestos whose life has been spent chiefly In rural areas. 3) occupationally exposed to asbestos with asbes* tosis, 4) occupationally exposed to asbestos without asbestosis. Fibre counts and ferruginous bodies counts to be made in the lungs and compared in order to determine whether there is any relationship between asbestos related disease and fibre content of the lungs. This one year study should test feasibility of method available to authors. Or. Paul Gross, M.D. & Dr. R. T. P. deTreville, M.O., Industrial Health Foundation, 5231 Centre Avenue, Pittsburgh, Pa. 15232, U.S.A. Cost: $19,921. ALV 0011026 1 SI q > - 1 KVMiaf Imcc- " or 37<*9 kdCAflM Cross. P.. Davis. J.M.C., Harley, R. A. Jr . , Cralley, : i.J. it S IT V7 1 A4V f P 1 Mar's "9*11 r 25 U3 76 iiheitoe: identification of fibrous .particles in.lunas. ,T . nrrup. l>f (10>r757-7S<. 1072 _ T1 80 Summary Ikium of proven nompscificitv. lenugmout bodietare not necettarily in dicative ol inhalnd atbetiot libm Of ihr methods uulul in identifying atbetiot fibers. rtrctron diffraction and microprobe analytic, while- more definitive. have proved eecttttively laborious and eifwntnre. A newly developed, rapid screening method for atbetiot vt nonatbettot fibert baa proved 10 be practical and economical in our ute In addition, with lhit method the lorm of atbetiot. chrytotile. which repretenn 95% el the atbetiot used in dvt couniry. can be identified: it it recognued readily by the unique tubular ttructut* of its libnllar umtt. Betidet atbetiot. inorganic libera lound m himan lunft may comitl of glatt. rock wool, or ceramic aluminum tilicate. Fibrout Iragmentt of diatomt have alto been identified The athrt of plantt and their denvativet--leavet. wood, paper, and coal--contain mineral fibert of rctpirable tue which find their way into and remain ip the lungt. Methodt of quanuuiing the fibert in lung tedimentt are detenbed and result* in a tmall tenet of lungt are turnmanaed. On the average. 7$% of all fibert were thorter than S u m and about 14% of the short fibert were chrytotile T> biological tignificance of the atbetiot content m lungt of people not occupationally exposed to atbetiot it bnefty ditcutted a1 imt rnouwd niMhUi ruU< nr<vn 5ewt pm*m ALV 001102? ! COM 2S 2T *SL, _2'_ -4 3796 GROSS. Paul, DAVIS, John H.G., HARLEY, Russell A. (Jr.fpr 6i CTt..T.c deTREVTLI E . Raberr T-PWom Lvmahdtie transport of fibrous dust trom the lungs. J. of Oceup. Med. 15 (3): 186-189, H<rch 1973 43 46 I hr (uwcmijiiwh d inhilni minml duvl tnd mmc*4l hbm mi ihr lung* 4*yJ 71 viicll.lv lymph nmlCN d 10 prop* -r 80 ,k<crm.nnl 4ml MbuUicd. !** con- cpnirjimm 'JnKir*fi Imm nwrly loui mi mow ihjn lS million l*-* K'*m d dry imur *cff liwiid mi i4idliir lymph win Apprutimiirly *>* pit cem d *H Mitm n idcnnlird ii ch*voiile AlihnuRh W% d lh* libm irmjmcd undi-niilicd. cogfd miwm" rr gtvm lo* not helming lh4i 4 ugniliC4nl pMtim nl ihrm liv min* nudr nor ml*-* jnmwtr n* croeidolii*. snd l<M eonnidttmg ivo 01hr* probiNc dcntilim 'mi condAimn mm found between iibrr ciincei*4iiun m lymph nodn 4nd lung no* *' h*** 4ny co**d4imn bnwnrn lh* i>br* con, (ymrtuon in lymph nodn 4nd conccnl*4iion d mme*4l dull in either lung or lymph nodn. Ha wm > il >> INOEX TRICING CARO - 94 - ALV 0011028 M'l AIT COM -2043 JUi_k_ 4-9- -12- 80 GROSS. Paul 6 HARLEY. Russel.A.: tine Th Ineua nf nathOffnifitV Of *shstns. Aav-hiv Pm/i rnn HAlTh.77 (4):24Q-2H L Octobr. 1973- OaCaaWAtel tviAlltCt, M Ml M IM ratulta el prahimnary a.atrv- atenia, an praaantal wkieh iaeicatt a re- euchea ia aainoitnieity aa Uia pallia- atenttue arran|mani al atbtitat aval pattidta ia raptaetl IT moaeKiamtaieua urvetmri. On Me taut a* H eviPtace. ia prapaaae Mat Ma tacua al patMcaitortr al aakaataa Mat Miwut nuata ia mair petytHamaateaa avactvra. MCI 3872 km torn OOCw ^fU Oroaa, Paul; Harley, Runell alar e. -Sc 3934 kOC*ViO D*vi, John M.C. h Cr alley, ACT COOC KIT HQAQ Qt CWAAACTIAIITIC Mineral fiber content of human lungs acoaa aorta Levi a J , JLS_ 43 Aaer. Induat. Hr. Aaa'n J_. ; 35_ (3_Li_ 1U8-1S1. March 1974.---------- ------------------- 73 TT JLL 80 Miami fltoa* la tto toaga al M fltutoretora 7 wartort aapaae* ta atotatae Putt hart tom iff** aaltto-- tota PtscfttoP ia tom* toliM. AHlKh.ik.lto *ar.ile '* faaap fat paaplt al tto aaaw aaa aaa al tto aama mm.autory. tto tomto macm-- trwiea al apUcaUr *WMa pelmaaarr .^2lTl^altoa- aaaaa Urnaa aa Mah aa that al Ctoftasealaa.. Tto toama tolaa^ macaalfallaa al aptkalip aialMa flton U paapla aa. --'Mll-nUl M--" *3.- 1.7* al (to mw taaaaamrte. al u*- **iac*t&o .toLM*a+la ntoaafta w-acrt platMa itoIa, f > --a. W*"--"" - .hiip*. tJ* wara itototflaHa aa ctoraatlle. - 95 - ALV 0011029 ALV 0011030 PROJECT No. 14 ALV 0011031 Project No. 14 - Fibre shape and biological activity OBJECTIVES : 19 samples of fibres (glass, microquartz and asbestos) of various lengths and diameters to be tested for carcinogenicity in groups of 50 hamsters each. The tests are designed to disclose whether carcinogeni city of fibrous particles is dependent on some critical shape, independent of chemical composition, and thus controllable by a general principle. Cost: $276,000. Or. William E. Smith, M.D., Director - Health Research Institute, Fairleigh Dickinson University, Madison, N.J. 07940 - U.S.A. - 99 - ALV 0011032 Up* 'V I"""' MCJUIS *Ht T^" - Kvmitl 230 > i(v COM 38 --n-- 43 44 ----- *T5-- ----- EB-- 74 fv *0*0 oa C*a*CTt"'STiC The Intrapleural Route as a Means for Estimating Carcinogenicity Reprint from: Experimental Lung Cancer Carcinogenesis and Bios says Springer-Verlag - Berlin 1974 oo. 92-101 AUTSACT KOM -- -----------{ ........* i I Xntrathoraclc tumors have bn reported ttom several laboratories after Intrapleural In)action of various praparatlont of ainaral. sub stances into experimental animals. Application of Inforoatlon froo aueh studies to problems of pulmonary carcinogenesis involves con sideration of whether tuners so Induced arise fro* aesothelial colls ot the pleura or fron other cells of the lungs or thoracie cage. Another question atens fron the fact that direct introduction of test substances Into the pleural space dose not reproduce natural routes of exposure to Inhaled carcinogens, however, the Intrapleural routa nay serve a useful role as a convenient screenihq procedure In conperlson to laborious, repeated intratraeheal Injections or the large specs requlrenents of Inhalation exposures. In experlaents with haastars exposed to a variety of preparations of aabestlform and other minerals, we have qlven each anlnal only a sin*It Intrapleural Injection. Multiple injections present undesirable vari ables, since early granulomatous responses to a single Injection en tail variations In deposition of subsequent Injections. After single Intrapleural Injection of hamsters, we have seen upward of SO animals with lntrathoraele tumors spreading along pleural surfaces in a manner characteristic of mesotheliomas. For purposes of this paper, these tumors will be designated as mesotheliomas, although we were able to trace thalr derivation from the mesothellum only in rare eases, moat of the tumors being too large to Identify their pre cise origin. Data from these experlaents show that tumor response to chrysotlle, amoslte, and crocldollta la related to dose. Tumors regarded as meso theliomas arose la response to preparatlona of chrysotlle containing numerous fibers visible by optical microscopy but not In response to preparations la which the great majority of fibers were visible only by electron mlcroecopy. ALV 0011033 ALV 0011034 PROJECT No. 15 I i \ \ I -- 103 - ALV 0011035  Project No. 15 Fibre diameter of dust in mining, milling, manufacturing and insulation operations OBJECTIVES : A preliminary study to be carried out of the asbestos fibre diameters of airborne dust to which workers are exposed to a) mining and milling, b) textile manufacturing and c) insulation work. Five samples to be collected at each of at least 3 locations in each of a), b) and c). All samples to be examined using a scanning electron microscope and the diameterand length of fibres to be measured. Results to be interpreted in the light of available epidemiological information. Cost: $18,630. Dr. G. W. Gibbs. Ph. D.. Department of Epidemiology and Health, McGill University, Montreal, Canada. (Continues-as IOEH.S22) - 105 - ALY 0011036 MNIII fiTtC GIBBS, G.W.: (Kill IV Irsct " or Mur * 4J57 -- " *t coot 0 2 tv nono o* CHsascTtaiSTic Fibre release from asbestos garments 0 Ann. Occup. Hyg. 18: 143-149, 1975 icon koto - 3 64 itM.The concentrations of airborne fibres (> S am) in tha breathing tones of "Often 74 vearinf asbestos safer famtsau were measured uung the membrane Biter method. Ai plant 1 here men vote atbewos coats, hoods and mutant, concentrations of fibres ranted from 61 pj M Kbrcacm* and the 1 hr ume-et|hied concentration, from 0-1 to I I fibtaafcm'. At plant 1 where hoods, coots, mittens and leuiitfs note vom, concemrauona of airborne fibres reused from 9-9 to 2i-2 fibreafem' and the 1 hr lime^eifhiad average concsnirsiios aa T fibrn/cm'. Counts of fibres collected on Nuckpoce filters end ciammed Or scanniM ^ slsaren microcopy showed that the concentrations of fibres > 5 on in Infill rcprvimsd 1 JJ-JJ nor tool of iho tool airborne fibre. The difference between (he fumutits of fibre T nimri from the ferments at the different pUnts was probably "land la iha methods or 1 materials ostd ia garment manufacture. Tha toaulis showed that there is a omd to identify and to reduce the release of Rbre from aabestoa safety faimants currently tupplied to protect persons worfcmf in hot environments. tUM ILlKl 0i< m INOCX/THACING CAPO ALV 001103? I PROJECT No. 16 -- 109 -- ALV 0011036 Project No. 16 Study of the health effects related to asbestos exposure in workers of the industry and other residents of New Orleans 2nd phase (Continuation of IOEH #8) 1) Analysis of data collected in previous study (IOEH #8): a) correlation of clinical features with radiographic changes and pulmonary function; b) relationship of pulmonary function and total dust exposure; c) relationship of smoking and radiographic changes and pulmonary function. 2) A study of mortality in 8,000 previously employed workers in the two asbestos cement factories. 3) Follow-up examinations (in three-yearly inter vals) of the 300 men aged 40-59 from the original study group (IOEH #8). Dr. Hans Weill, M.D. & Dr. Morton Ziskind. M.D., Tulane Medical School Section of Pulmonary Diseases. New Orleans, La. Cost: $270,000 ALV 0011039 <* '"ii U|V coot 13 " 64 76 80 ROSSITER, Charles E. 6 WEILL, Hans; Ethnic differences in lung function evidence for proportional difference IS . International J. of Epidemiology, 3 (1): 55-61. 1974 91 4033 scon norn - --: cvaiaf tru * 13 _2_ 80 .-------- :------------------------------------ ----------------------------- UNII* coin* m _ t*ec ROSSITER. Charles E__ 6 WEILLx...Hans_ III MH 00 QuatCTCaiSTtC ^ynryiim between dust exposure and omnUngt an artefact in the statistical annlynfn nf lnny function. Rnl1rin Physio-pathologic Respiia 1t. 737-795. 1974. ABSTRACT la * group at workers npai'l to a Sum haxard. cigarette smokers had won* Kibj (unctioa than noiwmokrrt. This difference increased with increasing dost of dost or duration of exposure. The obvious inference is that cigarette smoking increased the response to the dust exposure, but this may be an artefact. For many indices of lung function, changes with age are greater in cigarette smokers than in nonsmoken. To correct lung function for age differences, predictive equations are used, but these ate usually regression relations calculated from a group of subjects including both smokers and non-smokers. Thus the predicted change with age lies between the actual average changes for makers and non imakers. Consider, for example, the forced expiratory volume which declines with ap. the decline being greater in smokers than non-smokers. The values for nonsmokers will tend to be above the predicted, with the difference increasing with ap. For smokers the opposite effect will occur. If dust exposure hat an effect on the lotted expiratory volume the effect will usually be to reduce it. to that in smokers, lung function it reduced relative to the predicted both because of smoking and because of the dust exposure. At total or duration of dust ex posure it correlated with ap. the reduction will be greater for the snort heavily exposed subjects. For non-smokers, lung function it increased relative to predicted by non-smoking and reduced by the exposure haxard. MClMBCar ao. o# 4046 kOCATa KON worn INW IlfHI ''u > II INOCX, TRACING CARO ALV 0011040 cr COOC 70 76 80 Wolll, H. StV *00 CH**CTIlTlC Epidemiologic Methods in the Investigation of Occupational Lung Disease (Editorial) American Review of Respiratory Disease. Vol. 112. Ho. X, July 197S pp. 1-6 wot _2!_ 4191 kom Horn _ - -- 114 -- ALV 0011041 PROJECT No. 17 -- 115 - Project No. 17 Relationship between asbestos and tissues (Continuation of IOEH #6) OBJECTIVES : A. Mechanlsm of coating In formation of tha aabastoa body to bo atudlod: 1) in the lungs from patients with asbostoaia; 2) in tissues of animals exposed to asbestos and various other dusts; 3) in cell cultures of fibroblasts and macrophages; 4) in vitro systems incubating asbestos and various other dusts with substances present in asbestos body coating. B. Studles on the relationship between the asbestos content of the lungs and the degree of fibrosis: To be examined; 1) lungs from workers exposed to asbestos inhalation with and without fibrotlc lesions; 2) lungs from comparable non-exposed popula tions; 3) tissues from experimental animals exposed to asbestos and to various other dusts; 4) fibroblasts cultured in vitro with asbestos and various other dusts. Or. Benvenuto Pernis, M.D., Instituto di Medicina del Lavoro della University di Genova, 16132 Genova, Italy -- 117 - Cost: $45,000. ALV 0011043 PROJECT No. 18 119 - Project No. 18 A factor to convert total airborne dust concentrations using the midget impinger technique to fibre counts as recorded by membrane filter method (In progress) At 20 locations at each participating asbestos mine a minimum of 5 duplicate samples of airborne dust will be collected using side by side millipore membrane filters and midget impingers. These at least 1,800 samples will be counted at McGill and by participating members of the industry. Simultaneously the total and respirable mass concentration of dust will be deter* mined using Hexlet and/or MRE samplers. Objectives are: 1) The calculation of a conversion factor, to convert midget impinger counts to membrane filter fibre counts; 2) the description of observer variation in counting fibres using the membrane filter or total dust using the midget impinger techniques. 3) Measurement of total and "respirable" airborne dust mass concentrations in the mines and mills to examine their relationship, il any, to particle and fibre counts. i* Dr. G. W. Gibbs, Ph.D.. Department of Epidemiology and Health, McGill University, Montreal, Canada. - 121 Cost: $37,375. ALV 0011045 PROJECT No. 19 - 123 - i i Project No. 19 Epidemiological study of mesothelioma in U.S.A. ii OBJECTIVES : 1) Ascertainment of fatal cases of mesothelioma by getting an answer from every pathologist as to whether or not he has made such diagnosis during the previous year. 2) Visits by M.D. to every pathologist who reoorts a case to review the case and to select a control case. 3) A field survey in which Public Health Nurses obtain occupational and residential histories for cases and controls. 4) Pathological review by the U.S. mesothelioma panel. Dr. Alison McDonald. M.D., Department of Epidemiology, McGill University, Montreal, Canada. Cost: $59,600. ALV 001104? ALV 001.1046 I PROJECT No. 21 ftLV 0011049 PROJECT No. 22 - 131 -- [ Project No. 22 Further studies of the physical parameters of airborne fibres in various industries (Continuation of IOEH #15) (in progress) Airborne samples of dust will be collected at each of the 20 locations with asbestos exposure in various trades in America. South Africa and Finland for which important epidemiologic stu dies exist. The samples will be analysed with ob jectives: 1) To ascertain the diameters, lengths, mass and aspect ratios of the fibres in various occupations. 2) To relate these physical parameters of airborne dust to the health experience of workers in res pective occupations. 3) To explore the relationship between concentra tions Of fibres visible by light-microscope and fibres of electron-microscopic size in various occupations. Cost: $76,278. Or. G.W. Gibbs. Ph.D., Department of Epidemiology and Health McGill University Montreal, Canada. ALV 0011051 I I r (hi a|i C00< " S6 60 61 62 63 U3 44 45 2 3 74 76 __ai_____ INK! ir imi Gibbsi GW Hwang CY It woao oa CH*a*cTiaitTic Phvsiral Parameters of Airborne Asbestos fibres in Variout_Wrk Environments - Preliminary Finding American Industrial Hygiene Association Journal, Vol. 36, No. i June 1975 - do. 459-466 MCvaiaf Ct O' kK*1ll61 icon *oui * - IV maiM af a pOal bmhlshlaa la iarii tka Mnfch nwitw* Wahk, i m mi akaoa of aitkaraa flkna la a rartaty af r iihm tiMi mi Vaatka af hitana Ikia caHartH kahaa iwfMB plaai m (iMMf Ikaa ikaaa h i unarm Oarinf tka aaakraitoa af Iraki imlnlaa. Ckryaatlla flkm taMacMf V *a taka araa af aa aakraaa Utah plaat aha aalaf la Ian tmallar laaawi ttaa flbna taHarttf la tfca *y hf katfiai arm af aa aakahaa aSL Tka aiaai aaah af fkn <laiiaalaaa laOrau tkat fla arena af amacHaa affaraaa a attar ky taaah aalaa tta anaitnai nhar tarkhaaa h Ikrir la ftpatf aa rariaty af i mi haaa af Qntaakaa fnllalaary waalh an aal la aaafla ! math fan naathlaa Itat aatiaihi alike ka nlaraf la Ika nan af afctaraa ah yrtaary aaftaaaM anaikrHh Man la aipaaan la flhna la a af flkta flaaalar aaf kaflk. KI II ' I INOCX TRACING CARO l ALV 001105? PROJECT No. 23 -- 137 - I Project No. 23 Differential pH analysis of chrysotile : pilot study its application for measurement of dustiness at working places (In progress) OBJECTIVES : 1. A B C To determine accuracy of the method on known mixtures of pure chrysotile and inert matrix. To analyze dust specimens supplied by QAMA to determine the minimum specimen quantity required. Search for interferences such as brucite. 2. (1) Continuous pH determination during HCI attack at high temperature in aqueous suspension using a recording pH meter and automatic burette. 2. (2) Analysis of titrated solutions by atomic absorption. Cost: $1,000. MM. J. C. Roy and C. Barbeau University Laval D6partement de Chimie Quebec. Canada ALV 0011054 PROJECT No. 24 Project No. 24 Nature and specificity of the rales found in workers exposed to asbestos (In progress) Part A 1. Study, by objective sound recording and analysis, of the nature of the rales heard on the chest of persons exposed to asbestos. Attempt to determine whether these rales are unique as compared to similar breath sounds found in other diseases. Part A 2. Quantitative study of the observer variability in assessing rales from patients with asbestosis and in distinguishing them from similar sounds found in other diseases. Part B. Development of efficient system for collection of breath sounds data in industrial surveys. Cost: $64,650. Dr. Raymond L. H. Murphy Jr. Faulkner Hospital Boston, Mass.. U.S.A. 02130 ALV 0011056 #* 1**61 If >< ***** MURPHY Raymond L.H.: ICY COM 10 ' 11 76 " 55 (V aO*> 0* CN**CTC*ltTIC Human factors in chest auscultation. Human Factors in Health Care, 5: 73-88, 1975. (no summary) r*e OCvasiat or 4289 UUt*8 kou *oto 1 -- M* frta<0 T 1**60 0* wwT 10 U 76 80 H0LF0R0 Stephen Kent: KIT WO*0 O* CMAftACTCftlSTIC Luna sound analysis In the dlaanosls of pulmonary asbestosls. THESIS: 115 pp. - CIRCULATED - Front oaae & Abstract. February 1976. MCI or 4323 bOC**** KOM *OTCI - 145 - - --- f\LV 001105? PROJECT No. 25 % - 147 - ALV 0011056 Project No. 25 A study of the health effects of dust exposure in the manufacture of asbestos cement and other asbestos-containing construction products PHASE III (In progress) (Continuation of IOEH #16) A. Continuing analysis of cross-sectional data on Xray and dust exposure in slightly less than 900 workers, currently employed or recently retired in early 1970. B. Longitudinal study of a cohort of currently employed workers. The cohort will be re examined in 1976 and 1977 in order to obtain clinical, radiographic and physiologic indices of any adverse biologic response. These data will be correlated with ongoing and future characteriza tion of the plant environment in order to establish current correlative information. C. Mortality study. D. Differences in health effects resulting from chrysotile and crocidolite exposure. E. Environmental characterization. Exposure cha racterization in this industry by correlating total dust measurement with fiber counts. Dr. Hans Weill Professor of Medicine Tulane University School of Medicine New Orleans, Louisiana U.S.A. Cost: $215,427 e ALV 0011059 PROJECT No. 26 - 151 - Project No. 26 The reduction of airborne asbestos fibre concentrations in industry using charged and uncharged water aerosols (In progress) Asbestos clouds will be generated in the laboratory exposure chamber and water fogs, charged and uncharged, will be applied to the clouds. Effects of a variety of water fogs on concentration of dust clouds composed of fibres of various lengths and diameters are tested. Cost: $46,190. Drs. Gibbs and C. Pengler Occupational Health and Safety Unit Institute for Mineral Industry Research Mont St-Hilaire, Qu6. ALV 0011061 PROJECT No. 27 - 155 r Project No. 27 Fibre exposure, mortality, and radiographic changes in the Quebec chrysotile production industry (In progress) (Continuation of IOEH #10) Study I. Mortality and radiological study of the mining population of "a posteriori" type in order to estimate the relative risks of the various fibre concentrations. All men 45*64 and employed 30 years and more will be involved. Study II. Study of mortality related to previous clinical signs and symptoms ("a priori" study). Over 1,300 men who had radiograms, function tests and ques tionnaire in 1967-1968 and about 5,000 men born 1891 -1920 whose radiograms were read in 1967 will be involved. Study III. Study of difference of effect of slip fibres and cross fibres. Radiograms of men employed "purely" in one of three selected mines will be investigated. Cost: London $241,000 Montreal $ 57.075 Docteur J. C. McOonald TUC Centenary Institute of Occupational Health London School of Hygiene and Tropical Medicine London, England and Or. G. W. Gibbs Occupational Health and Safety Unit *-- Institute for Mineral Industry Research Mont St. Hilaire, Qu6. _ ALV 001106 PROJECT No. 28 - 159 - ALV 0011064 Project No. 28 Interrelationships between the haemolytic effect of fibrous minerals in vitro and their effect on the alveolar macrophage and their fibrogenicity in vivo (In progress) 1) Quantitative measurements of haemolytic activity of the various fibrous materials. 2) Feasibility study of the material obtained by broncho-pulmonary lavage following application of asbestos with the aim to see whether measu rement of protein and lactate dehydrogenase can give information on acute damage to macro phages still in the lung or whether disturbance of the kinetics of the macrophage system or enzyme release can be seen in vivo as sign of delayed cytotoxicity. 3) Quantitative determination of pulmonary fibrosis as related to dose of fibres and their clearance rate. Cost: 19,200. Dr. A. Morgan Environmental and Medical Sciences Division B 551 Aere Harwell * Oxfordshire, England ALV 0011065 PROJECT No. 29 - 163 - Project No. 29 Distribution of particulate material in the rat lung following administration by inhalation and by single and multiple intratracheal instillations (In progress) (Continuation of IOEH #21) Both fibrous and non-fibrous material are used radio* actively tagged for the above study In animals killed immediately after application and at later times. Also effect of dust load on clearance of the material from the lungs is studied. Cost: 45.200 Or. A. Morgan Environmental and Medical Sciences Division B 551 Aere Harwell Oxfordshire. England ftLV 001106? Expenditure* incurred by the Institute of Occupetionel end No. Protect Authorised ISM 1SS7 ISM 1 McOoneld 6230.000 6646400 2 McOoneld 6.940 -- 3 McOoneid-Gibbs 4 Oumont S Vigiieni 17.790 11.266 69.000 --' -- -- 6 Perms 49.000 -- 7 Noro 42.000 -- 8 Tulane Univ. 291460 -- 9 Beattie 3491 -- to McDonald Addendum si Addendum o2 474.700 10.000 38470 11 Gibbs 92000 -- t2 ind. Health Pdn 19.921 -- 13 Vigliani 49420 -- 14 Smith 276.000 -- 19 Gibbs 18430 -- 16 Tulane Univ. 270.000 -- 17 Pemis 49.000 -- 16 Gibbs 37479 -- 19 McDonald (Mrs.) 99400 -- 20 Green 33449 -- 21 Morgan 46 400 6 111420 22 Gibbs 76478 -- 23 Roy-Barbeau 1.000 -- 24 Murphy 64.690 -- 29 Tulane Univ. 219.427 -- 26 Gibbs-Fengier 46.190 -- 27 McOonald-Gibbs 296.079 -- 28 Morgan 19400 634460 29 Morgan 49400 6 61460 -- 661.400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- 666479 6.9a 9490 6.000 4.999 9.412 9497 -- -- -- -- -- -- -- -- -- -- -- -- _ -- -- -- -- -- -- -- -- Sub-Total 634494a Gathering 6 Distribution ot Scientific data, operating costs, etc 6M.000 113.197 661.400 6109.789 6 161.336 153.7M GRAND TOTAL 6199.197 6242.736 6263.599 6 8LV 0011068 APPENDIX LIST OF CODE NUMBERS USEO IN IOEH DOCUMENTATION l. Environmental OaU 0. Exposure to HMtisi - occupational 1. Exposure to asbestos non<occupatlonal 2. Exposure dasaitisd aa to magnitude or typo. 3. Oust Counts 4. Oust Control 9. Cancarogsnatic hydrocarbons suing with asbestos _ 6. Mauls acting with asbestos 7. Solvents acting with asbestos 5. Other impurities or compounds acting with asbestos . Exposure to asbestos by ingestion ll. Clinical Data on Asbettoeis 10. Manifest clinical asbestosis 11. Findings in physical examination 12. Radiological findings 13. Pulmonary function findings 14. Classification 19. Differential diagnosis 16. Women and asbestosis 17. Occupational health care of patients with asbestosis ill. Pathological Data 20. Anatomical findings in asbestosis 21. Ferruginous bodies in the lungs 22. Ferruginous bodies in sputum 23. Ferruginous bodies in lymph nodes 24. Ferruginous bodies elsewhere in the body 29. Asbestos fibres and dust in the lungs 26. Asbestos fibres and dust in sputum 27. Asbestos fibres and dust in lymph nodes 28. Asbestos fibres and dust elsewhere in the body 29. Fata of asbestos fibre 120. Phagocytosis of asbestos -169- ALV 0011065