Document v44RMb7dpZNwVNw0NrR1XqG6

ARQ86 -- 1283 Telomer Research Program Bl AGC = Clariant. WIR ------------------------------------------ 82 Telomer B Alcohol Biodegradation Research `Scope and Rationale The Telomer Research Program (TRP)' is investigating the biodegradation potential and pathway(s) of 8-2 Telomer B Alcohol (CoFi;CH:CH:OH; CAS #67839-7), a primary fluorotelomer intermediate. The 8-2 Telomer B Alcohol is a key raw material used in the `manufacture of sales products and was selected as a starting point for identifying environmental fate pathways for telomer-based products. The TRP began this work by first developing fundamental physical-chemical property data for the substance including water solubilitsys, Sorption properties, UV-Visible absorption spectrum and vapor pressure. These propertiesare = essential to determine and understand in order to develop rigorous sampling and analysisS SP inthods in advance of conducting biodegradation studies. The 8:2 Telomer B Alcohol vas. 123 found to have a water solubility of approximately 150 ppb at 25C, 3 Pa vapor pressure aE 201 ambient temperature (20C), and significant sorption to a number of types of surfaces. As guy result of its low water solubility, hydrophobicity, volatility, and a propensity to partition from water to air when sorptive medium is not present, the 8-2 Telomer B Alcohol has proven itself to be a "difficult to test substance." Furthermore, the study material lacks structural characteristics that would enable it or any ofits potential transformation products to be identified and quantified at parts-per-billion levels in complex matrices by sensitive spectroscopic, speatrophotometric, or fluorescence detection techniques. Thus, a parallel research effort defined, developed and prepared [3-'"C}-radiolabeled 8-2 Telomer B Alcohol to be used for quantitative biodegradation studies to facilitate the best opportunity for developing a compound mass balance and both quantitation and chemical identificationof transformation products. In advance of the successful preparation of the radiolabeled 8-2 Telomer B Alcohol, pilot studies were initiated to develop sampling and analysis methods in relevant test matrices using NThee cmomop&aCnuoimepsrapnasryt.iciTpahteisneg ncotmhpeanTiRePs pirnoclduudceeAMsosrioiGlloasmse,r-ClbaarsiaendtpGroHduc,ts,DwahkiicnhIrocduustsics4danMducE.r.osduurfPcoanndttes and surface protection chemicals. CompanySized DosomCoiSCAnCBI Page1 0f2 Telomer Rescarch Program 2 "cold" 8-2 Telomer B Alcohol. This work included extraction-recovery methods to identify appropriate solvents, conditions, and procedures for recoveryof the parent 8-2 Telomer B `Alcohol and potential transformation products as well a the preparation or purchaseof high purity samples of the potential transformation products such as CyFi:CH:COOH, CF1sCF=CHCOOH, CF 1sCOOH and CsF11COOH. The final report from the biodegradation screening work was submitted to EPA in mid-March 2003. With the radiolabeled test material in hand, safe handling, sampling and analysis methods are being verified at this time. Procedural review, evaluation and training in the safe handlingof the radiolabeled 8-2 Telomer B Alcohol was conducted to ensure the safety of all personnel working with this material. The frst biodegradation study to be conducted by the TRP is a 28-Day OECD 301D, Closed-bottle, Ready Biodegradation study (under Good Laboratory Practices) wiilizing unacelimated municipal sludge with radiolabeled (3-/"C] 8-2 TelomeBr Alcohol. This study follows earlier screening studies conducted by DuPont. Meanwhile, a study to determine the adsorption-desorption behavior of radiolabeled 8-2 TelomeBr Alcohol for a rangeofsols and sediments is underway. These two studies will provide essential data for design and protocol development foar long-term, higher tier studies on 8-2 Telomer B Alcohol. Currently, the TRP has a study protocol in development to define a sediment or sil biodegradation study that would emulate long-term, more environmentally relevant conditions. Biodegradation Studies Timeline Summary DuPont ready and accelerated biodegradation screening studies reports. Submitted 21 March 2003 + Results from the "C-labeled 28-Day OECD 301D biodegradation study will be available in June / July 2003. The adsorption-desorption study (soil, sediment, sludge) is expectteod be completed in Jul/y `August 2003 with a study report following. The timeline for study protocol definition and developmentfor a longer-term study of sediment or soil biodegradation is contingent on the resultsofongoing studies described above. CompanySuid Docs ox Cons TSCA CBI Page 2012 5 Telomer Resarch Program