Document v1zKwq0r634LJ34XbgbYM0Dr8

February 12, 1930 There, are two possible defenses, without consid ering any strictly, legal and technical matter9 of whieh 1 have no knowledge. The one concerns itself with demon strating that the alleged injury is not due to the effects pf the absorption of tetraethyl lead. The other would maintain that in, case the effects are due to the absorption of tetraethyl lead, there is no grounds for suit since the injury so sustained is compensable under, the state laws as lead poisoningo (1) The first of these defenses would be difficult, if not impossible to present convincingly. There are four elements, which enter into the formation of a diagnosis in this case, viz.- (1) the question of the significance of the subject*s exposure to lead; (2) the matter of the similarity of the symptoms and signs of illness to those commonly seen in lead poisoning; (3) the existence of laboratory findings specifically related to lead; and (4) the relationship,'in1 time, between the occurrence of expo sure and the development of the injury as now seen. In the case of this man there was undoubtedly a significant exposure. Pis exposure was of such a sort that when I saw him at the reconstruction Hospital in 1926, I conclud ed that his symptoms at that time might -..veil have arisen from the absorption of tetraethyl lead. I do not remem ber the details of his work, whereby he received his ex posure, but I would not have arrived at that conclusion without sufficiently convincing evidence. His exposure to lead since that time has apparently been negligible so that all considerations as to the significance of the exposure must go back to the original period of experimen tation and contact v/ith Ethyl Fluid. ' The symptomatology displayed by the man at pres ent is not specifically and certainly due to lead. Further more the usual outcome of exposure and symptoms such as lie experienced in 1926 or there abouts, is that all of the effects disappear and no residual injury remains. On the other hand his present symptoms apparently cannot be proven to arise from some other cause, and they are compatible with the generally believed behavior of lead compounds. In so far as an expert opinion, based on recent experimental Information, might be formulated, it is reasonable to sup pose that a man who has absorbed a considerable quantity of tetraethyl lead would have nervous system symptoms chiefly, and that these symptoms might persist indefinitely, or recur after havkog abated. This opinion is based on our findings, verified in"part b;-; English, observers, that the central ner vous system binds lead and retains it for long periods of time o This brings mo to consider the laboratory evidence obtained at the eeonstruetion "capital in 1926, which tends to show that Evans5 load excretion was not such as to'warrant - 'iagnosis of load in -.oxieukion. lucre are several reasons 'or discounting the validity of conclusions based on this evidence. First, it can be shown that after tho elapse of a year, the lead excretion in ouch.a case will have reached a. level which is practically , that of the normal unhxposed per- con. (Xn: this instance* there was an interval of more thaif.a year, between the period off - exposure and the time of observa tion.) The use of ammoniunj chloride and ammonium acetate in such a case does not always promote an increase in excretion. ' his is especially true when the subject's lead content is low, as was probably the case, here after the elapse of - more' than a year, Thorsfora this negative finding is of no sig nificance, because it showed what might have been expected, - r rie that his general load content was low. On the other hand, it tells nothing as to the lead content cf his central nervous system - the tissue-abbut which information is most wooded. Finally the method by. which the lead analyses were carried out foes not yield uniform results which are suscep tible to proper interpretation:. For all of these reasons the analytical data available on Evans contribute little to the solution of the case. The information obtained by blood examinations is in approximately the same doubtful position. It would not be expected that stippling of the red blood corpuscles -.could be present to such an extent as to be diagnostic after the elapse of more than a year since exposure. It can be shown that an important amount of stippling does not exist in most cases after three to six months from the cessation of exposure. The absence of stippling, however, does not mean that lead may not- be the cause of the symptoms, for here again no information is obtained as to the lead in the central nervous system. The long period of time since the exposure indi cates a considerable likelihood that some factors other than lead are responsible for the present condition of the subject, However the previous discussion shows how lacking are proofs of the point. One's tendency would certainly be to give a nick man tho benefit of any doubt that existed in this con nection. Kf .00174.55 . kSSSSisS&Sffi -o- It might be feasible perhaps to present the alternate bo the effect that "vans' Injury if occupational at all, has arisen from v/ell recognized lead hazards, and, as lead poisoning, is compensable under the laws of the State of lew Jersey. It would be highly desirable to have this matter settled once and for all, and in such a way that the nature of poisoning from tetraethyl lead might be understood. There has been too much vagueness and awe surrounding the subject. It should be classified as in no way different from other forms of lead poisoning. This has been done from the first in Ohio, and all cases coming under this category have been so dealt -:3 th. - If any evidence is needed on the scientific and clinical aspects of the matter, such can be found in medical literature, and in further experimental work which, we are soon to publish. In fact, it can be shown.that tetraethyl lead is decomposed In the tissues and eventually behaves in a manner which is identical with that of the v;ateh soluble compounds. Its distribution in the body, its rase of excretion, and its clinical results on the blood and other- tissues are identical with that of other lead compounds. It would he difficult to find any point of variation except for its initial peculiari ties due to Its original fat soluble character. It would be difficult to anticipate the effect that the facts t have discussed would have upon a jury, but it would appear that a judicial decision might well be made which'would take the entire matter out of the hands of a jury. I trust that the above paragraphs make my position sufficiently clear, and I submit them for what they may be worth. Kf igned) Eobt..A. Kehoe, h.D. :EJ KE 0017