Document v1jDjM2kKMJqXLJj5Dop348eb

FILE NAME Brakes BRK DATE 1988 DOC BRK109 DOCUMENT DESCRIPTION Journal Article - Asbestos Associated Tumours in Car Mechanics - British Journal of Industrial Medicine RCV BY XEROX TELECO AG. toe o1 nal aren o- 2HNL ee m EXHIBIT NO 15 7 1:24 ; eee Sennen 313 390 66909 FORD - LEGAL - STE 300W Mr. Krause Please Please Please note NA Viola 31322335 402 this nutidsf aA A - Gilli cl1s Toxicul ok J^...richV. Conney All els Pergamon Press 3. Concentration yrene oxide in the macol Exp Ther nary hematology Vol 1. Midland Inmental Biology ew : a . ~~ ii 4 wy ye yes ~ pm Fo : a Journal British Industrial Medicine 645 646 Asbestos associated tumours in car mechanics ~ J^ RVHOLMJBRISMAN JBRISMAN From the Department of Occupational Medicine Sahlgren Hospital 412 66 Gothenburg Sweden > Asbestos in brake linings and clutches clutches is considered to be a major source of asbestos exposure to the general public Nevertheless the asbestos exposure to the car mechanics from this source during repair of brakes and clutches is several times higher It has been Suspected that the exposure may cause lung cancer or mesothelioma in car mechanics and the union asked for an investigation To study this subject we used linkages between the census of 1960 in Sweden and the Swedish Cancer Register and the Swedish Death Register respectively This is a report on the preliminary findings Methods The census of 1960 contains information about occupational title and industrial category in 1960. Wc used mechanic as the occupational title code 752 and car repair as the industry code 354 According to this selection procedure the census contained in total 21 905 men table ) The Swedish Death Register contains all Swedes who have died since 1952 and the underlying cause of death according to the death certificates A linkage between the death register and the census is commercially available It gives the observed number of cases 1961-73 for a certain diagnosis and the expected numbers calculated from death rates of the general population The linkage between the Swedish Cancer Register and the census includes the years 1961 to 1979 and is called the Cancer Environment Register It gives only the cases of cancer for different sites From Statistics Sweden we received the mortality ~ Accepted 7 September 1987 oane; - iN Table Year of birth of the car mechanics Year of birth -1890 -1890 1891 1900 1901-1910 1911-1920 1911-1920 . 1971 1930 1931-1940 1941-1945 ' No 38 493 1587 2948 4755 7420 4664 for each age class and calendar year between 1961 and 1970 and could subsequently calculate the person- years for this period By assuming the same mortality as the general population we estimated the person- years for 1971 to 1979. The expected number ofcases | was then calculated by multiplying national incidence rates with the corresponding person stratifying for age class and calendar year When using the data from the Cancer Environment Register we restricted the analysis to between ages 20 and 69. The linkage between the death register and the census contains all ages Results and discussion There was only one case of mesothelioma in the cancer register and none in the death register This was a 42 year old car mechanic who was diagnosed in 1978. He had also worked in the construction industry at least since 1965 but his medical record contained no information on total work history or possible exposure to asbestos Between 1961 and 1973 741 mechanics had died versus 776 expected Of these 187 _ had died of cancer versus 154 expected p < 0.01 whereas 39 had died oflung cancer compared with 23 expected p < 0-01 Table 2 Table - Cunter morbidity in cur mechanics 1901 1961-70 1961-70 5~ Form of cancer _ All Lung cancer Mesothelioma Stomach cancer Observed 265 30 0 13 Expected 249-7 258 - 22 _ 7i9n men agedaged 20-69 compared with the male general popullation 19179179 19 Observed 396 63 ! 29 Expected Expected 388-7 47 256 256 1961-79 1961-79 Observed 661 93 ! 44 Expected 6384 73.0 * 48-2 Rates not available for cakulation of expected incidence _ 4 645 4 aa - . tt