Document v1drJzL6NKevbMpMvBkveED89

* r V. y ** i v- rn ( i 5 ? .5 f >./ ' * l. I ::'u\*r . 11\s>-si August, 1Q60 the w.*U!u *' 'ViU!Hnl; luvr) such welding or cutting operations on xmc-silicate cu.te$J steel in po.*(rJv v oisi;.r.,{ ytivu rig to fumul containing -4 to *5 time* the maximum allow able l**VAv*.> lcvl, and \ Vj 14 times th.t MAC oi zinc. Tlte am operation* on Valvar.*.('.yJ steel under similar conditions produced fumes containing l to 4 times the MAC of load, enu i to !.! times the MAC oi cine. When ventilation was adequate the MAC was not grc.vti* or onu'isU nil v exceeded for either tvpo of uiutni coating. -* Author's summary .*1.1 A Mino-Ancw <;`.rcc cad Poisoning: tne Manufacture o: >*rrr-Tn.s for Kirctclo Llcht i.. More.:. Med. Jivoro 50. iNo. I5!?bVK llliian. The author rcu.'rts 1 case* of lend t -.jomng, oi:v female and the other a male :n cpisrst'.vc* making t'*v icrrn'.es for electric bu'.bi, The p.:i*cn;ng is considered tohsve ariron through the ;.;e of i soft {into v'.i-.h I he J. mut.il aupp^rturs for th :'i:an:ijii are p. seed! w ith . lu.'d '.v.:c:: which varied fret:: 1-. .`3* '*. to o*'l. The :Vf;..tlu patient had worked for II years .i machine which automatically placed a blob of she fused glass on to the sop of the ferrule, hut she had had Attacks of colic, vomiting, and oliguria 3 months before admission She hac an enlarged liver, signs of kidney damage, and a tree erythrocytic protoporphyrin o: 340 tvucrcgr.im 'l und a postvoricnate urinary lead of 8,250 mtcrogrsms per 24 hours. The man had worked at one of the furnaces removing the luted glass for 2 years,ana 24 months before admission hod a;t obvious attack of lead poisonino. l\'o estimation of the lead content ot the air near tnc jurnjce* \ut carried out aut a laboraiorv experiment showed that it was possible `ora* much .v i to 4 mg. oHv-d per cu.m, per hour to be emittvc. The author is certain that these l cases arose from the nature of the work ana points out that they are the first to be recorded in the literature. Cane, iron: E-.i. Hyg. i l / i < 'i i4 ;j i * i * W 'oi A Study of C.arhrn Tetrachloride. The Effect of Carban ivtracMoride Inhalation on Ha; $e Knsvrcc t. H. H. Cornish r.nu Vt . D. pTock. A.M.A. Arch, Lid. Health 31, 544-554 (June lt*0). A single 4-hour exposure of rata to l.OOC or 1,500 ppm of carbon tetrachloride vapor res;:t in marked variations in the level of serum, glutamic-oxalacetic transaminase xanthine oxidase, and esterase. The extent cf eniymatic change bears a direct re lationship to t!u deg/ve of exposure. During repeated daily exposures over a 1'3-day period, rk&rgvt ir. scrum. cr.;vmo Activitc could be demonstrated at exposure levels cf 100 and 0 ppin car hen ::ra. ::h*ride vapor. Ir. general, the lemtle rat exhibits a more marked enaymatie mronse :o carb.u*. tetrochlcride inhalation than Az-vt tht male. While increases in serum v:OT ar.d \Mithir.w oxidase maybe cue to release of encyn.cs from damaged tissue, the de crease noted .n serum estror must be accounted for by some other mechanism. Authors* summary *-S v*h .'igee in Ethvlene l>tbrom.ide Poisoning, . V, Clnistead. A.M.A. Arch. Ind. Health 21, h25-24 (June 160), Si.trch of the literature has failed to reveal a description of the patholugicai changes tc kthv'.one dibronndc poisoning in humans. It was therefore felt wurtkwhile u Cv'C.iniir.t more chitr.gee u* observed ir. a case which cam* to necropsy. Etbylr. dibrcui.ice is used As .t soil fumigant for the control of ground pests. It is available in pullet fc?:: sr.t :i ordii;ar:.y dissolved in water for use in the soil. Thousands o/gallons are crns~;r.v2 *:.> :i. the Ur.tle.1 States. It is known to bd^a^highly.tc.xic,material, and its systemic orjl ingestion are directed toward the liver and kidneys in experimental animals. iibromide i also used commercially in "leaded'* gasolines and as a chemical ir.urn.eaiate. Tbe autker describes a case of a 43-yar-old whitv woman who ingested ? Fumisol cepsules, each ccr.tair.ir.y .\S nil. of ethylene dibromide. The patient died 54 hour* after ingvaticnof the poison. The yAtr.ological changes resulting from the ingestion of 4.5 ml, of etnylen* difcrornide are descriVvd. Tbe :r.a;or changes were characterised by massive central lobular necrosis of t!: Hv*r ith focAl proximal tubular spithelia) damage in the kidney. Tot so changes parallel these found in various experimental animals after oral administration of this chemical. i n.