Document v1BmyOLR69Mx0zbvjRKVJbVwY

Liver Angiosarcoma Cases Circulation Or K S Williamson Dr G Paddle Dr D P Duffield Dr W G F Adams - (5 copies - ICIA, Hr John York, Everberg Mr J G Davies, Everberg Dr D W Plester Mr H R Jervis, Mlllbank Mr Brian Hasler, Vinatex Mr Peter Heron, BP Mr R H Hards, BIP Vinyls Dr J T Carter, BP Mr T L Phillips, BP Dr P Lewis, CIA Dr J P Tassignon, Solvay Mr J Jauvert, Chloe Chimie, Paris Dr Renzo Mattiussi, Montedison Mr P Lechaude, Solvay Dr B List, Lonza Mr P G Claus, APME Dr J G Kammuller, Shell Mr S Wejdllng, Kemanord Dr David Byren, Kemanord Mr P Rangncs, Norsk Hydro Dr B Terwiesch, CWH Mr II Emminger, VKE Dr E Lloyd-Jones, BP Mr Owen Jones, Hlllhouse Dr Brian Bennett, Hlllhouse Dr Peter Wright, P & P Wilton Dr F W Best, Everberg Mr C Celia, Montepolimerl Mr GDupont , APME Dr CBishop, EMAS Mr BWerner, EMAS Dr RSpirtas - NCI/NIH BETHESDA Dr E W Dacey - NIOSII,Clncinattl Dr R Owen - TUC !)r J Stafford (8) AECI, Duperlal) Dr T R Torkelson, Dow Mr J Lawrence, SPI Mr J T Seawell, CMA Washington Mr R N Wheeler, UCC Dr A Ross Adams, Air Products Dr Mayo Smith, Air Products Dr John Barr, Air Products Dr Walter D Harris, Unlroyal Inc Dr Robert K Hinderer, BF Goodrich (Cleveland) Dr R A Krueger, BF Goodrich Dr M N Johnson, BF Goodrich Dr J Possberg, Wacker Dr J Rety, Chloe Chimle, St Fens Dr J C Aubrun, PCUK Dr H P Frledel, Berufsgenossenschaft der chemischen Industrie, Heidelberg Dr E Ernst, Berufsgenossenschaft der chemischen Industrie, Nurnberg Prof Dr Thiess, BASF Dr D M Ferguson, ICI Americas Mr A G Mash, ICI Americas Dr Gary Ter Haar, Ethyl Corporation Prof. C Maltoni, Bologna Dr J William Lloyd, Osha Dr David Bryson, AG Division Mr S Nakamura, Japanese PVC Association Dr Peter Baxter, CDC Atlanta Dr A Mumi, Monsanto, Brussels Dr R E Gosztonyj Jr, Tenneco Chemicals, Saddle Brook (NJ) Dr Donald W Hillman, Diamond Shamrock Dr G Kent Hatfield, Diamond Shamrock Dr Pierre Bertazzl, Milan University Dr Hans Popper, Mount Sinai Medical Centre Sir Richard Doll, Warden, Green College, Oxford Dr J Keir Howard, CIA l)r Henry Falk, CDC Atlanta Mr J R Wallace, Esso Chemical, Sarnia, Canada Dr F l Lee, Victoria Hospital, Blackpool Dr D M J Williams, BP, Barry JS/MM/DSO-16 20 January 1982 PJXS7917O920/WPX Wide 11 VVV G 0G 003753 VVV 0 0 0 0 0 3 7 5 4 PREFACE ACKNOWLEDGEMENTS, SIGNIFICANT CHANGES AND COMMENTS During a visit on 14 September 1981, Dr Fukawa and Mr Taklne of the Japanese PVC Association gave me Information which has resulted In the deletion of the 3 unconfirmed cases alleged In the Japan Times of 27 October 1975. Of the three cases, Mr Sato and Mr Ono were confirmed as not being ASL cases though Mr Sato had portal hypertension attributable to VCM exposure. In the case of Mr Tanaka, It has proved Impossible to confirm whether or not he had ASL - Mr Tanaka died in 1969. I am grateful to the Japanese PVC Association for Investigating these 3 cases. I am grateful to Dr M N Johnson of B F Goodrich for his letter of 16 September 1981 in which he confirmed that US Case 22 Is a B F Goodrich man and that the case was described in the Dannaher, Tamburro and Yam paper in AMJ 70 1981 pp279-287. Dr Johnson makes the interesting observation that there are no known US ASL cases in plants South of the 36th parallel. This raises again the conjectures about climate, open/closed plante, time employees spend In open as opposed to inside covered plants as a factor in the incidence 6f ASL cases. Ms Rose Kaminski has moved from N10SH to CDC and responsibility for the NIOSH ASL register has been taken over by Edward W Dacey to whom I am indebted for his letter of 16 October 1981* This letter gave Information about US 31 at UCC. The information was augmented In the letter of 9 November 1981 from Mr R N Wheeler Jr of UCC to whom 1 am grateful for much Important detail. In his letter of 2 November 1981, Dr David Byren of Kema Nord was kind enough to give me details of a fifth Swedish case. This has occurred at the Sundsvall plant and though the man died In 1980, his diagnosis was not confirmed until one year later. In their letters of 9 and 22 December 1981, Dr J Rety of Chloe Chimie (formerly Rhone Poulenc) and Dr J C Aubrun of PCUK gave me full details of French Case 14. I am further indebted to Dr Rety for sending me a copy of two papers written by himself and his colleagues describing in detail French Cases 9 and 10. [Archives de Maladies Professionnelles Vol 40 No 6 of 1979 pages 741 to 744]. I am Indebted to Mr H P Friedel of BG Chemle, Heidelberg for Ills letter of 21 December 1981 giving details of 3 Interesting new German cases, two confirmed and one as yet unconfirmed. The two confirmed cases died In 1980; quite clearly histological confirmation can take a long time and one must therefore be very careful about drawing conclusions about annual rates of ASL cases. I have asked several times whether the annual Incidence was decreasing and I am now satisfied that it Is not decreasing. The 3 new cases reported by Mr Friedel are also fascinating because they were all first diagnosed many year's ago. They are all at Dynamit Nobel who now have a cluster of 10 cases. Of the 90 cases reported here, 40 are in 4 factories viz BFG Louisville (11), HFG Shawinigan (10), Dynamit Nobel (10) and UCC S Charleston (9). 7 Dr D M J Williams of BP has provided detailed Information on UK 8 which will no doubt be submitted to the UK ASL Panel for confirmation. 8 At the suggestion of Sir Richard Doll, Table 4B has been included to show some detail of distribution of latency periods. This has coincided with the reporting by B(5 Chemie of the three interesting cases G 20, 21 and 22 which were diagnosed in 1974, 1974 and 1972 respectively but died in I960, 1980 and 1981. Just as in the case of US 17 (Mr Peerenboom) who was diagnosed as ASL in 1974 and died in 1980, I have treated the latency period as the date from first exposure to first diagnosis of ASL (or death if sooner). Normally the interval between diagnosis and death is a few months though there are a few cases of 1-2 years. These cases of 6-9 years survival after first diagnosis are exceptional. John Stafford Division Manager Health and Environment Protection ICI Petrochemicals and Plastics Division Bessemer Road Welwyn Garden City England JS/MM/20 January 1982 ^ 0000375S IMPERIAL CHEMICAL INDUSTRIES PLC PETROCHEMICALS AND PLASTICS DIVISION ' LIVER ANGIOSARCOMA CASES (REVIEW DATA - 17 AUGUST 1981) Table Sequence Belgium Canada Czechoslovakia 1 ASL Case Numbers by year of Death (Table 6) 2-3 ASL Case Numbers by year of first exposure A (Table 7) France Cermany Italy 5-7 8-12 13 Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Cases (Table 9) Japan Norway Sweden 1A Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10) 15 East European PVC Producers - Start-up Dates vs ASL Cases 16 (Table 11) UK USA Yugoslavia 17-18 19-23 24 Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South & Central American PVC Producers - Start-Up Dates (Table 13) Incidence of Cases pa (Table I) 25 Distribution of Cases by Country (Table 2) 26 Pattern of Cases by Factory (Table 3) 27 Latency Periods (Table 4A) Distribution of Latency Periods (Table 4B) 28 29 > Annual Geographical Incidence (Table 5) 30 31 32 33 34 35 36 37 38 0 0 3 '> '50 o o o > VW 000003757 IHI'KHIAI. CHEMICAL INDUSTRIES PI.0 PETlNM.TIEMIOALS AND FJ.ASTICS DIVISION LIVF.R Anglosarcona Cases - (Review Dates 20 January 1982) PS 1 11 23 |COUNTRY AND | REFERENCE 1 NO NAME OR INITIALS DATE OF BIRTH |BELGIUM 1 4 COMPANY 1 15 | 1 1 1 FACTORY 1 | 1 1 6 FIRST VC EXPOSURE 7 DATE OF D1ACNOSI9 1 8 9 10 I II AGE AT X YEARS OF XJ 1 YEARS OF | DATE OF OIACHOSIS EXPOSURE TO EXPOSURE | DEATB DIAGNOSIS 1 X XJ ( 1 1 12 13 t 14 1 HISTOLOGICAL 1 1 ESTIMATED | l 1 | CONFIRMATION EXPOSURE | OCCUPATION | LEVEL 1 | X1 1 J 1 11 13 OTHER CAREER IIICHL1CIITS 1 1 I | | 1 1 1 16 OTHER COMMENTS 1 1 i | | | I 1 1 ot 1 1 1 1 1 1 1 1 1 1 1 1 L JJ2.OI.I3 SoIvey ] 11 1 11 1 1 < t1 11 1 1 Jeaeppe 00.07.SB 00.OS.76 1 1 1 1 1 1 11 l 1 11 1 1 11 1 1 1 11 1 1 1 I 1 1 1 1 1 11 1 1 1 11 1 1 1 1 ( 1 1 1 1 1 1 1 1 1 63 IB .L _L 1 _L _L X 17 129.06.76 1 1 11 Tee 11 1 11 1 11 1 11 1 11 1 11 ! 1 11 1 1 I 1 1 11 1 1 1 1 1 1 1 1 1 1 1 1 1 1 i 1 XJX High |Autoeleaner IDrfller In (Hepatic taru | |I4 yre |foundry tin Oct 1974 | 1958-1968 { 1(2 yre) (were noraal. | exposed toj Polyworker | paraer |Retired | 200 pp* (3 yre 1(13 yre) (Feb 1975 | 1 for ( hre j |Uork in glass IHoepltalUel | per day | |lnd. A cheat- I May 1976 | 1 and | certainly | under ] leal Industry 1 1 1 (Cosplete (Clinical anj 1 | | 500 ppa in 6 to 93 | ( J 1 1 1 (career detallaj (are given In a| (paper by | 1 utoclaveai 1 1968-1972 | exposed to) 1 1 IHublet et i: | |In Arch, felg.j (Hed. Soc., ^ 50-200 ppa) 1 (Hyg. Mad. | 8 hre per J day In | 1 25a3 | 1 1 1 (Tree. fed. |Ug. 11977 page* | | | autoclavea| 1 (601-622 i 1972-1974 ( 1I exposed to| 50-200 ppa | In auto- | 1 1 1 ( 1 1 1 i ( clave rooe| 1974-100 | 1 1 1 1 | I PP 1 1 1 | 1975- 50 | 1 1 1 PP* 1 1 1 | RETIRED | 1 I I 1 Feb I975| 1 1 i 11 1 1 11 1 I 11 1 1 11 1 1 1 11 1 ( 1 1 11 1 1 11 1 1 11 1 I X1 X J____________ 1 IHPKKIAL CHEH CAL INUIISTKIES PIC PETROCHEMICALS AND PLASTICS DIVISION LIVER Angloeurcimo Cueee - Rovluw Date: 20 J.muary 1982) All datea uae UK ayetem Canada DAT - MONTH - YEAR Sheet I Data published In journal of Occ Med 1978 page* 336-140 Hany of datea altered to fit NIOSH 31/3/77 list Page 2 country and REFERENCE NO NAPE UR INITIALS DATE OF BIRTH CANADA 01 15.12.13 02 06.01.14 03 26.08.19 COMPANY FACTORY SIUWINICAH FIRST VC EXPOSUHE DATE OP DIAGNOSIS 1944 1941 1955 1957 1941 1962 ACE AT DIACNOSIS 41 43 42 YEARS OF EXPOSURE TO DIACNOSIS 21 10 II YEARS OF EXPOSURE DATE OP DEATH 02.09.55 14 21.12.57 20 23.0).62 12 HISTOLOGICAL confirmation 13 14 X I ESTIMATED | EXPOSURE | OCCUPATION LEVEL | _______ I__________ 15 OTHER CAREER HIGHLIGHTS 16 OTHER CCKMKNTS I I Yea |Reactor Oparator Smoker (cleaner polymerisation J_______ Yea |Maintenance. Operator Worked |millwright, overtime (pipefitter Smoker J________ __ 1 Yea (Operator. Worked Iforeean overtime Non-aaokar 04 05.04.19 1945 1967 48 22 22 21.01.68 Yea (Reactor Icleaqer Operator, foreaan. water coaling unit Worked overtime Smoker 05 07.05.11 1944 1968 57 24 05 05.07.68 Yea 06 15.12.19 1947 1971 51 24 23 10.04.71 Yaa 07 09.11.19 1946 1972 51 2b 25 24.12.72 Yea 08 I 3.05.20 1961 1971 53 12 05 12.06.73 Yea .X. 09 19.07.21 1946 1974 51 28 26 04.09.74 Yea i'.j[n-r l>y Hi F DEI.OKMK In Annulna d'AnaLomle |>a tholog I quo Parle, 1978 23 Mo 2 ppl05-ll4 clnlma this cauc Lad both a hepatoma and ASL almultan (Reactor Icleanar I J_______ I [Reactor (cleaner I J_______ 1 (Reactor Iclaaner Water cooling unit Worked overtime Smoker Maintenance, millwright Worked overtime Smoker Machine chop operator and poly unit Worked overtime Smoker (Reactor (cleaner Maintenance machine shop In plant 25 yral Senior IPurnace op. (pipefitter (Maintenance J___________ y. Worked overtime Smoke r VVY C 0000375B .1 VVV 0 0 0 0 0 3 7 5 9 IMPERIAL CHEMICAL IHDUSTK1ES I'M: PETROCHEMICALS AND PLASTICS DIVISION LIVER Aiigluaarcuna Caaea (Review Data; 20 Ji>i<uary 1962) DAY - MONTH - YEAR Slteet 2 * All dates use UK ayetea Canada ** Data published In Journal of Occ Ned 1978 pages 338-340 *** Many of dates altered to fit NIOSII 31/3/77 list Pag* 3 COUNTRY AND REFERENCE NO 2 NAME OR INITIALS 31 | 1 DATE OF 1 BIRTH 1 1 4 COMPANY I 3{ 6 11 11 1 FIRST VC | FACTORY | EXPOSURE 11 7a 9 Ml 11 12 13 XX X XX X DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL 1* 1 1 1 OCCUPATION | 1 IS OTHER CAREER HIGHLIGHTS 1 | 1 1 1 1 16 OTHER COMMENTS CANADA 10 16.05.13 1953 1976 61 23 14 (00.04.77 Yea Reactor cleaner Furnace op. maintenance, packaging Ei-amoker ) 1 .. L 0 0 0 0 3 76C IMPERIAL CHEMICAL INDUSTRIES Pl.C PETROCHEMICALS AND PLASTICS D VISION LIVER Angloanrcoaia Canes - (Review Da e; 2(1 January I9B2) rail 4 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY J___ FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS 10 YEARS OF EXPOSURB 12 DATE OF DEATH HISTOLOGICAL CONFIRMATION I) ESTIMATED EXPOSURE LEVEL 14 OCCUPATION 15 OTHER CAREER H1CHLICHT8 CZECHOSLO VAKIA 01 00.00.28 Slate Co Novsky 00.00.57 00.00.73 46 16 16 00.00.74 Yea 02 _L. 00.00.26 State Co Novakjr 00.00.51 00.00.66 40 15 00.00.66 Yea 16 OTHER COtttENTE > > > __________ L. _l VVV 0 0 0 0 0 3 7 6 1 IMPERIAL CHEMICAL INDUSTIM' ^ PJ.C PETROCHEMICALS AND PLASTICS I [VISION LIVER Angiosarcoma Cases - (Review Untei 20 January 19112) Prance Sheet 1 Page 5 I 11 1 ii 1 |3 1 A |5 6 1 11 1 8 9 10 1 II 12 13 1 14 1 >5 1 16 1 l1 _J X X X _L X JX X J___________ 1 1 1 i1 (COUNTRY AND ( NAME OR | DATE OP 1 11 1 FIRST VC DATE OF ACE AT YEARS OF YEARS OP 1 DATE OP II1STOLOC1CAL ESTIMATED 1 1 | OTHER 1 | OTHER REFERENCE ( INITIALS | BIRTH COMPANY | FACTORY EXPOSURE PIACNOSIS DIAGNOSIS EXPOSURE TO 1 EXPOSURE I DEATH CONFIRMATION EXPOSURE | OCCUPATION | CAREER I COMMENTS HO 1 1 1 DIAGNOSIS 1 LEVEL 1 | HIGHLIGHTS 1 11 1 XX L JX X1 1 1 1 11 1 11 1 TRANCE 1. 1 1 1 1 1 1 1 11 1 1 11 1 | 1 01 | H 113.0A.24 RP | Rouse-* 00.0I.A6 18.02.67 43 21 19 119.02.67 Yea High I Autoclave ( |Ref. Ravler etj 1 11 | 11 Lon 1 (worker and 1 lal Arch. Hal. 11 1 1 Icleaner 1 IProf. 1 30 a* j 11 1 1 |I9 yra I (3 Nov 75 11 1 1 11 Ip 171-177 11 1 1X 11 1 11 1 11 1 02 | S IK (03.06.11 PCUK 1 Br ignoui 06.07.59 13.01.7$ 63 16 12 124.01.75 1 Yea High (2 yra on |Italian |Ref . il 1 1 1 1 (NIOSH no laonomer (origin |G Ronneton -t 11 1 1 coancnt) 110 yra on 1 |al "Houvell* 11 1 i |polymer- 1 |preaee ;| 1 1 1 1 Jlaatlon 1 laedlcale" l| 1 1 1 1 11 (5 Nov 1977 ll 1 1 ; 01 1 | NAV ii 1 1 1 1 J06.0I.20 1 HP 1 XX X X 1 JSt Ponn 00.00.46 15.01.75 55 29 1 1 X JX 1 29 (29.06.75 1 Tee 11 Ip 735 X1 1 J 11 1 High JPolyworkcr JVCM production!Ref. Rety v: |10 yra as 116 yra Jal Arch. Hri. n 11 1 1 lautoclave 1 Italian POW IProf. 1 37 .i* i 11 1 1 Icleaner JShepherd, |6 June 77 i 11 1 1 |Compounding |Sawyer. Maaon |p 551-555 i 11 1 1 13 yra 1 1 i 1 1i 1 X1 11 1 i 11 1 1 11 1 i 0* |HOP J27.OI.27 PCUK | BrIgnoud 19.10.49 16.01.76 49 26 26 104.01.76 Yea High I Monomer 1 1 i 11 1 1 (production 1 1 i 11 1 1 |worker 1 1 11 1 1 IB yra 1 1 ! 11 1 1 1 IPVC 1 1 1J 1 11 J1111rat Ion 1 1 11 1 1 11 1 |I8 yra 1 1 11 1 XL l1 11 J 11 1 1 11 1 1 1 03 JR 179.01.Ill PC UK |RrIgnoud IB.01.65 13.05.76 38 11 11 (13.05.76 Yea High (Polyworker 11 )Tlioracotoay | Ref. P CoiH rre| 11 1 1 1 1 III yra |9th Feb 1976 let al "Seailntl 11 1 1 1 (costal Idea hoapUaux 11 1 l 1 11 jangloaarcoaa 110 Septealrs 11 1 1 |2)Sclntlgraphy|1976 1 11 1 111 11 11 |found ASL (Previously bed/ 11 1 l1 1 |3)Hae*orrhaga I bone 11 1 l 11 1| |from ASL langloearccaa" 11 1 11 1 f 111 1 11 1 1| |4)Rlght |Hepa tec tony (Also | |PI 1 Ichowak: et | 11 1 1 11 11 1 (el "La Noe ell e 1 11 11 1 1 11l 1 1 11 1 11 11 1 1 IPrease Ktcl:il |7th July IT79 | X, L _X X X JX X1 1 IPaae 24*' 1 VVV 0 0 0 0 0 3 7 6 2 IMPERIAL CHEMICAL INDUSTRIES Pl.C PETROCHEMICALS AHU PLASTICS DIVISION LIVER Angloearcuiaa Canes - (Review Date! 20 Junuury 1982) France Sheet 2 Page 6 1 11 1 |2 13 1 1| l1 |COUNTRY AND | NAME UR | DATE OF REFERENCE | INITIALS | BIRTH NO 1 1 (FRANCE 1 1 1 1 1 i 4 COMPANY 11 |5 6 1| 1 1 1 PIKST VC | FACTORY 1 EXPOSURE 1 1 1 1 J 71 a 1 9 11 10 ( 11 |1 11 1 DATE OF 1 ACE AT | YEARS OF YEARS OF I DATE OF DIAGNOSIS 1 DIACNOSIS | F.XPOSUKE TO 1 EXPOSURE 1 DEATH 1 | DIAGNOSIS 1 |1 11 1 11 1 12 13 i 1 ( J. 1 1 HISTOLOGICAL CONFIRMATION 1( ESTIMATED 1 ( EXPOSURE | OCCUPATION | LEVEL 1 | 11 11 1 19 OTHER CAREER H1CHLICUTS 1 1 1 1 | ( 1 1 1 1 16 OTHER COMMENTS 1 1 | ( 1 | 06 |Pa i t i i i i i i i i i 07 11; I r 1 1 1 1 ( 1 08 1 8 1 1 1 1 1 1 09 IRIX I 1 1 1 1 1 1 1 1 1 1 1 1 1 l 1 1 t1 |14*04.34 1 I'CIJK |BrignouJ |0|.0).56 1 12.08.76 1 42 1 i1 ii 11 ii 1( i1 ii 11 ii 11 ii 1I ii 11 i ii 11 ii ii ii 1 1t | 1 1 i 126.04.27 KP i 1( | St Aiiban 01.07.50 After 1 49 1 26 11 11 11 11 death NIOSH says 00.07.76 1 1 1 1 1 1 1 1| 11 11 |Q 1.04.34 Solve/ ITevatiX 23.05.57 03.12.75 1 42 t >9 11 1 11 1 11 1 11 1 11 1 1X 1 1 |0 B. 10.14 RP 1 | St Fons 10.01.48 26.04.76 1 63 1 28 1 1i 1 11 1 11 1 11 11 1 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 1 1i J1 l 1i 1 1 1 11 1 11 1 11 11 1 i 1 1 11 (11.09.76 j(NIOSH Yea leeye 112.09.76)1 1 1 1 1 1 1 1 1 22 102.07.76 Yee 1 (NIOSH no 1 comment) 1 1 1 1 19 (30.01.77 Yea 1 1 1 1 1 1 1 28 125.12.77 Yea 11 1 1 1 1 1 1 1 1 1 1 1 1 1 1i 1 1 i 1 Moderate High Moderate Very High 1948-1966 Leaeer Exposure 1966-1976 1(1958-1960) 12 yre |filtration (10-11 yre Ipolyworker land works llabf 1 1 1 1 1 1 1 1 1 1 1 1 (Tide am ha ; 1 |AOL prior t. 1 |AS. Ann. da 1 |Hel. Prof. 1 IJuly *77 1 |p 645 6 6. I (AOL was fou. i 1 (In 1971 flv |yr# before |ASL 1 11 1 11 1 |Plant fore-- (1972-6 adaln |01ed of !, |aen in (section In (aeptlcaeala Ipolyaerllsation 1 |St Auban 1 1 (Small liver i, lleelon form; i (after autopiy 11 1 (6 yra packer) (6 autoclave 1 Iclnr 1 ||4 yre (autoclave |worker 1 1 __ V1 i > 1 (Had been ij (tunnel worker i! (previously i' 1 j| 1i 1 i* 11 j 1 (Polymer(leetloo 1 |10 yre In (sulphuric 1i (Operated 4.76 i (for removal of| (operator, |scld factory. (tumour from i lautocleaner (storekeeper 6 lllver and i lautoclave (general (died after i (eainteuance (services I second i 11 (eurglcal i 11 (operation for i 11 Jblllo i 11 (bronchial i 11 (fistula i i1 (Paper by i 11 |Dr fiety et el i 11 | In Archival. de| (1 IHolades i 11 (Professionals i 11 |Vol 40 No C i 11 |1979 pages i 11 |74l-3. i .J J_______ L i IMPERIAL CHEMICAL INDUSTRIES Pl.C PETROCHEMICALS AND PLASTICS DIVISION LIVER Angiosarcoma Cases - (Review Date: 20 iunuary 1982) France Sheet 3 Page 7 1 11 l |2 |31 1 11 1 1l 1 COUNTRY AND | HAH OR | DATE OF REFERENCE | INIT! ALS I BIRTH NO 1 1 11 1| IFrance 1 1 11 1 4 COHI'ANY 1 |5 1 1 1 I FACTORY 1 1 1 1 67 _L FIRST VC DATE OF EXPOSURE 1 D1ACHOSIS 1 1 8 _L 9 ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS 1 1( 10 1 11 12 13 1 16 1 J J1 1 11 YEARS OF | DATE OF HISTOLOGICAL ESTIMATED I EXPOSURE I DEATH CONFIRMATION 1 EXPOSURE I OCCUPATION | 1 LEVEL 1 I JX X1 1 1 11 1 11 15 OTHER CAREER H1CIILICHTS 1 1 1 | I 1 1 1 16 OTHER COtttENTS 1 | 1 | | 10 (VP 1 1 1 1 1 II |L J I 1 1 1 1 1 l 1 1 1 41 1 l l 1 12 1 1 1 1 n1 1 1 1 l 1 1 1 1 1 1 14 1 UJ 1 l 1 1 1 1 (24.05.19 1 HP (Sc Fuim 1 00.12.56 10.01.78 58 11 l1 1 1 1| |15.02.12 1 RP 11 l 1 1 1 (St Fonu 1 1 | 00.01.41 1 12.08.7B 1 66 11 1 J 1 1 1 l1 11 11 11 11 11 11 11 11 11 11 (16.08.14 PCUK 1 IBrlgnond 09.02.49 00.05.79 65 11 I1 1 1 |I9.01.31 Solve? 1 1 (Tavaiix J 23.09.63 26.06.79 40 1 11 1 11 1i 1 1 1 1 I l1 1 1 1 1 1 11 1 11 105-04-24 Cliloa (St Pone 1 Clilole 1 1 1 (Fo rmorly 1 1 RP) 1 1I l 11 1 ( 1 t 1943 00.07.01 l 57 21 37 30 16 33 21 110.01.78 1 1 1 1 l 31 113.11.78 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 27 123.06.79 1 1 1 1 n (22.08.79 1 1 i i i i i i 1 i1 i 36 129.07.81 1 11 1 1 1 Tea Tee Tea Tee Nigh |Autoclave |10 yra in |Died of Icleaner Jaechanlcal (pulmonary 1 (engineering lembollvm 5 l 1 (Industry 11946-1956 (daya after laurgery High 1 11941-1946 Ipolyeer(teat Ion (general Ipurpose 1 worker 11946-1972 (VCH 1 l 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 laynthesla 6 (Acetylene) 1 1 1 1 1 |Foreman 1 1 Kagent |de waltrlae)l 11972 ( (retired 1 1 1 i 1 | 11 1 High 11 (Monoaer 1 l (production 1 1 land polymer* 1 1 Itaotlon 1 1 loperator 1 J lAutocleaner (2 yra aa cycle)Cigarette (1 (2 yre. |Autoloperator (mechanic. |10 yie aa lenaauller in (smoker unti 11974. Ill . ml (of 1977 due toll 19 yre. {aanltary vara |Oeaoptiegal (Copolymere (manufacture (varices. 1( ll |4 yra 1 1 1 1 1 I Surgical (interventitr (25.05.79 I (1 11 Very High 11943-1975 (1975-1979 1943-1975 |A11 type* of|maintenance and |Job* on | work Intcraltt--(aanutacture 1 eatly (6 aalntenance ((right Iheoatectoa;n 1 1 1 1 1 1975-1979 |ln VCM Poly 1 1Proceaa l 1 VVV 0 0 0 0 0 3 7 6 3 j j Ii i VVV 0 0 0 0 0 3 7 6 4 IHl'KHIAl. CHEMICAL INDUSTRIES Pl.C PETROCHEMICALS AND PLASTICS DIVISION LIVER Angiosarcoma Ceeee - (Review Date; 20 .January I9B2) Ceraany Sheet I Page 8 10 12 14 15 16 COUNTRY AND REFERENCE NO NAME OH INITIALS DATE OF BIRTH COHPANT FACTORY FIRST VC EXPOSURE DATE OP DIAGNOSIS ACE AT DIAGNOSIS TEARS OF EXPOSURE TO D1ACNOSIS YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COttlENTS CF.HHAHY 01 02 03 Oft 00.00.30 Dynara 11 Trolsdorf 01.10.56 19.09.68 38 12 12 25.01.69 Ye* (NIOSH) Polyworker 00.00.31 Dynsait Troledorl 14.10.57 25.09.70 39 13 II 14.12.71 Tee (NIOSH) Polyworker 00.00.30 Dynaalt Rlielnfel- 09.06.52 00.03.73 A3 21 16 10.10.73 Yee (NIOSH) Filling 1 | Reported undor <len (peetlclde 1 |non polyner- leeroeol cenel |leetlon (with VC 1 (worker* In I1 1 1 IN10SII llet c . (31.3.77. (Thle of com ,m 11 l1 )l (la strictly jcorrect. (However I 11 |wonder 1 1 )1 11 I1 i1 (whether thlw |aan had hlg'-. |expoaura to (VCH to hie (can fllllog (operation? 11 1 11 00.00.30 Wacktr Burg- 16.04.57 26.11.74 44 17 17 25.11.74 Yea (NIOSH) 200-500 ppe|Polyworker A|I958 vaa (Clinical Itaueen but high Iteaporery lautocleaner Idetails in during 1 yrlsutoclcener |for 1 yr (paper by eutocleaner| l 1 J 1 1 1 ICofcel it al IVlrchowa Ar. (A Path 1976 1372 p 195-2 1 IMPERIAL CHEMICAL INDUSTRIES TIC PETROCHEMICALS AND PLASTICS DIVISION LIVER Angiosarcoma Cases - (Review Dates.20 January 1982) Ceri- .ijr She. 2 ri| 9 1 i> 1 12 1 13 1 11 1 i1 | COUNTRY AND | NAME OR | DATE OF | REFERENCE | INITIALS | BIRTH 1 no 1 | ICKRMANY | 1 1 1 1 1 1 1 1 os | 11 KNIOSII gives) |se Case Ob) | |1 11 11 11 11 11 11 )1 11 11 11 11 11 11 t1 1 06 | 11 |{NIOSH glveal |as Case OS) | 11 1 07 | 11 11 11 11 11 11 1I 1i 11 11 1i I OB | (00.00.36 1 1 1 1 i l 1 1 1 1 1 1 1 1 1 1 1 100.00.32 1 1 1 1 1 |00.00.26 1 1 1 1 1 1 1 1 1 1 |00.00.I7 4 COMPANY 11 |5l 6 11 11 { | FIRST VC | FACTORY | EXPOSURE 1i 11 1i 11 Hoechat | Frankfurt | 02.04.60 11 11 1I 11 11 11 11 i1 11 11 11 11 11 11 11 Lonza Wacker Dynualt 11 (Ualdshut | 16.12.62 11 11 11 11 1 (Burg- (liausen 1 | 15.04.54 | 11 l1 11 11 11 11 11 11 11 1t (Truladotf | 19.07.54 78 DATE OF DIAGNOSIS ACE AT DIAGNOSIS 10.12.73 38 00.00.75 43 12.11.75 49 06.04.75 58 9 YEARS OF EXPOSURE TO DIAGNOSIS 1 10 1 >1 1 1 YEARS OF | DATE OF EXPOSURE | DEATH 1 1 1 1 12 HISTOLOGICAL CONFIRMATION 13 05 116.12.74 (Yea (N10SII) 1 1 1 1 1 1 I1 1 1 t 1 1 1 1 1 1 1 1 13 12 (09.01.75 Yea 1 1 1 1 1 21 21 (13.11.75 KHIOSH I aaya 12) 1 Yee 1 1 1 1 1 1 1 1 1 21 22 125.12.75 Yea 1 13 ( 14 1 1 ESTIMATED 1 EXPOSURE | OCCUPATION LEVEL 1 l 1 1 |BG Cheale 1 eaya |"chealatry |laboratorlan |ln the |TechnoI logical (Research |Department" KNIOSII aaya (assistant |factory (chealat Iwhlch aay be (wrong | translation) 1 1 1 (PVC - KamiI lecture (Shift Leader i 1 1 |PVC Hanu(facture end (all work (incl auto(cleaning 112 yr 1(1954-66) |Foreaan Tech |Dev 8 yra ((1967-1975) 1 1 t (Polyworker 1' onii cal: r Htr.ni i its 1 1 >6 1 1 | OTHER | COMMENTS 1 1 1 |Conf I med (Reported unt r| |non-poIywec|lsatlon (workers In (NIOSII llat cl | 131.3.77 and |1.?8. I dor t j (think this : | (a correct (claaatflcatl o| (by NIOSH. 1 e| (nan nay havi (been Involve | |ln VCN Ipolynerlsatl n J (In pilot pl< tj |or In main 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ( 1 T( 1 __ VVV 0 0 0 0 0 3 7 6 6 Im-KRIAL CIIKMICA' INDUSTRIES I'l.C PtTKoGIIKHlCALS AND PLASTICS DIVISION LIVER Angloserowa Canes - (Review Date: 20 January 1962) Ceraany Sheet 3 Page 1C _____ COUNTRY AND REFERENCE NO N/.'IK OR INITIALS DATE OP 31RTII COMPANY FACTORY CERMANY 09 00.00.39 CHII Marl 10 (N10SII gives a a Case II) 00.00.36 Ma rl ( NI OS It gives as Case 10) OG.flO.2? Wdcker Burgliausen FIRST VC EXPOSURE 20.02.61 01.01.61 10.10.55 DATE OF DIAGNOSIS 16.06.76 00.01.77 28.06.77 AGE AT YEARS OP DIAGNOSIS KXI'OSUKB TO DIAGNOSIS _L. 61 15 60 16 67 22 10 II YEARS OF EXPOSURE DATE OF DEATH 13 26.03.76 10 07,03.77 22 28.06.77 12 13 16 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION Yes High peaks 12 yra polyworker Incl 17X auto clave cleaning Control rooa I yr Yes High peaks 10 yra poly worker lncl I71 auto clave cleaning Yes High 3 yra auto clave cleaner 19 yra filter operator 15 OTHER CAREER HIGHLIGHTS Ii I 16 | Jt II | OTHER | | COmEKTJ || 10/76 Conflwlj I | Average j exposure f'?et| 9 yra ISO occ 1000 i p.| Next 3 yra <v,| 75 ppa. L it.| yr av 35 p i j' _______________I1 I Average |- exposure f ret|< 9 yra ISO ; jm,\ occ 1000 pa. j Last yr av j 75 ppa. C I | letter of |, 21.06.76 |l ----1! i i i i i 12 00.00.Jtt Uynantt Troladorf 00.00.61 00.10.77 39 16 07.10.77 Yea PVC Manu facture Autoclave worker for 6 yra i; i i i i i i \ i i i i IHi'KHlAI. CHKM[0At. INDUSTRIES FLC PETROCHEMICALS AND PI AST ICS DIVISION Cereanj Sheet i Page II I.IVCK Anglos4ircuid Caaee - (Ruvl. w Date: 20 January 1902) 11 2 1 | (COUNTRY ANO NAME OR DATE OF 1 | KEFF.RF.NCE j NO 1NITIAI.S BIRTH 1 1 _L _L 1 OF.RHANY 4 I 5I 6 COMPANY 11 1 1 FIRST VC | FACTORY | EXPOSURE DATE OF DIAGNOSIS 1t ___L 1 J. 6 ACE AT IMACNOSIS 9 YEARS OF 10 11 12 n _L X X XX YEARS OF DATE OF HISTOLOGICAL ESTIMATED 1* 1 EXPOSURE TO DIAGNOSIS EXPOSURE DEATH CONFIRMATION EXPOSURE LEVEL OCCUPATION | _L X X XX 15 OTHER CAREER HIGHLIGHTS 1 | 1 1 1 | 16 OTHER COMMENTS 1 13 1 1 I 1 1 1 1 11 1 1 1 1 1 1 1 1 1 l l 1 1 1 1 I 1 1 1 15 1 1 |(NIOSH glvesl | tills | Case 11) 1 1 1 1 1 1 1 16 1 l 1 1 1 1 1 -1 100.00.14 Lonta 1 1 1 1 1 1 1 1 1 1 J 1 1 1 1 1 1 1 1 1 1 1 1 l lJ 100.00.29 Hacker 1 1 1 1 1 1 1 1 (00.00.21 Dymwilt 1 1 1 1 1 1 _1 X |Wald shut | 00.00.60 11 1( 11 11 11 f1 11 11 11 11 11 11 11 11 11 1l 11 11 11 1l 11 11 11 11 11 |Burghausen 19.10.53 11 11 11 11 11 11 11 11 |Trolsdurf| 10.01.55 11 11 11 11 11 1( _l 08.04.78 | 09.10.78 07.08.78 L 1 1 1 1 l 1 1 i 1 l 1 l 1 1 1 1 1 1 1 l 1 1 | l 1 1 1 1 I 1 1 1 1 1 1 1 1 1 63 l l I 1 1 1 1 1 1 1 1 1 1 1 1 1 \ 1 1 1 1 1 l 1 \ | 49 1 1 1 1 1 ( 1 1 | 55 1 1 1 1 I 1 1 ___ L 18 25 23 ( 14 119.05.78 1 Yea ( 1 1 1 11 11 1 i 11 I1 1 1 11 11 1 1 11 11 1 1 11 11 1 i_ _J 11 1I 11 JI |Not an | | Angloaarcoea | |!n hia letter ( _i1 1 1 1 1 1 1 1 1 |of 21 12 81, | I (Mr friedel | 1 1 |aald thle wee | 1 1 1 1 1 1 |e *Plattenepi-| 1 \ |thelkartlnoe | 1 1 |Der | 1 1 1 1 1 1 1 1 |Spelaerohre' | 1 l I (a carclnoea | 1 1 1 1 l |of the | 1 1 (oeaopliagua) | 1 i 1 i 1 1 |not attrlbut- | 1 1 |abla to VCH 4 | i i i i 1 1 (not recognieed| 1 1 |ae an lnduat~ | i i i 1 1 1 (rial dleeaae | t i | 1l 1i i l 2S |23,|0.78 I Yea 1 1 |Autoclave | 1 11 1 Icleaner and | 1 11 1 Iwurker. | 11 1 11 1 11 I (Drier | I (operator, j 1 (Later ehlft j 1 11 1 (leader | 1 t1 11 1 1 11 f 20 (07.08.78 1 Yea 11 1 | High (Autoclave | 1 1 |ASL end | 1 1 |Hepetocelluler| 1 1 | Carclnoee | (worker till | 11964. | I Leader end | 1 11 I leaater | 1-- 1 1 11 1 1 11 I1 1 1 _J J______________ 1__ _l1 (P V Beat (letter of (30th June IS^0| (encloalng d<ta| If roe |Hr H F Fried 11 lof BC Cheat* |F W Beat fleeter of |30th June 11 0| (encloalng d.ite| If roe |H P Prledel f( (BC Cheat* (withdrawing |thle caee 1 1 1 1 1 1 1 1 |Angloaarcoe Iconftreed (09/79. Soai (detail of t ie| |A elao casei |9. 13. IS. i i | |6 17 given i | |NRU Report T>r| 11978 (Angloeercoa (confirmed, (full detail |of Ulneea lelnce March 11973 given ;. H | |NRW Med Ine IRee for 197) j_| VVV 0 0 0 0 0 3 7 6 N. IMPERIAL CHEMICAL INDUSTRIES FI.C PETROCHEMICALS AND PLASTICS DIVISION Ceraany Sheet I Pat* 12 LIVER Angluaarcuiaa Caaea - (Review Date: 20 January 1982) 1 11 1 12 131 4 l 1| 11 COUNTRY AND | NAi'C OR | DATE OF REFERENCE l IHIllALS | BIRTH COMPANY NO | 11 1 GERMANY 17 1 | | 11 1 | irnj.00*37 Dynaalt (NIDSl! Ktvcfll a a Case 15) | i i 1 i1 1i 1 i1 1i {t 1i 1i 1i 1i 1i 1i 1i 1\ 1i 1i 1i 1 10 1 i 100.00.13 Hoeclist 11 19 | 1 1 1 l l ) 1 20 | 1 1 1 21 i l l 1 22 | 1 1 L (00.00.25 1 1 l 1 1 1 1 100.00.15 1 1 1 100.00.13 1 1 {00.00.21 1 { DynaalC Dynamlt Dynamlt Dynaalt 11 1 1 1 3| 6 7| 8 1 9 11 1 11 1 1 1 FIRST VC DATE OF | ACE AT | YEARS OF | FACTORY | EXPOSURE 1 DIAGNOSIS | OlACNUSIS | EXPOSURE TO 11 1 | 01 AGNUS IS 11 11 11 1 l |Troladorf | 01.11.61 14.06.78 11 1t 11 1 11 11 1t 11 11 11 1 1 1 1t 11 11 11 11 11 11 11 11 11 {Cendorf | 00.00.55 25.12.79 11 11 ITrolsdorf | 16.10.54 00.08.79 11 1I t1 11 i1 11 11 |Troladorf| 00.00.61 07.02.74 11 11 11 |Trolsdnrf| 01.01.62 00.00.74 11 11 11 |Trotadorf | 11 11 IS.in.61 26.10.72 X | 41 1 >6 i 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 | 66 | 48 [Figure elven bv Mr Frledel preauaably learly diagnosis In 1974) | 57 (591) | 61 1 | 47 (517) 1 24 { 1 1 19 I(Figure glvan |by Hr Frledel Ipresnaably {early (diagnosis ip |I9747) 1 12 1 l 1 1 13 1 1 1H 1 1 1 11 1 1 10 1 11 12 13 1 . 16 1 15 1 16 1 1X XJ | 1 1 1 YEARS OF I DATE OF H1STOLOCICAL 1 ESTIMATED 1 1 1 OTHER 1 | OTHER 1 EXPOSURE I DEATH CONFIRMATION EXPOSURE | OCCUPATION 1 CAREER | C0MMEHT8 1 LEVEL 1 1 HIGHLIGHTS 1 1 1X XJ 1 1 1 1 l1 1 1 1 11 1 1 I 1 128.08.78 1 Yea High (Autoclave 1 No {Angloaarcoa* 1 |worker 1 {confirmed. 1 1 11 {Annual report 1 1 11 |of the Nort.i. 1 1 11 | Rhine 1 1 11 IWeatphalla 1 1 1I (Medical 1 1 11 I Inspectorals 1 l 11 {for 1978 1 1 11 Ipagea 347-377 1 1 11 Iglvee full 1 1 11 Idetalle. Vinyl| 1 11 Ichlorlde 1 1 11 Idlaeaae 1 11 {diagnosed 1 11 {02-02-73. 1 1 11 {Oesophageal 1 1 11 Ivaricas. 1 1 11 (probably ac .*<> 1 l 1| loateolvala. 1 21 (25.12.79 Yea |Autoclave 1 1 1 1 IWorker 1 1 1 1 |1 1 18 I 22.2.80 Yea {Autoclave 1 1 1 1 | Worker 1 1 1 1 11 l 1 11 1 1 1 11 1 1 1 11 1 1 1 1 13 {19.10.80 1 Yea 1 1 {Autoclave (Worker 1 1 1 1 1 J___________ (Details In {Mr Friedal* t 1 1 1 1 I 11 ILetter of 1 1 13 {19.06.80 1 Yea 1 |Autoclave |Worker | 1 1 121.12.61 IDetalla in |Hr Frledel1* 1 1 1 1 1 II 106.12.81 1 t 1X r iX 1 1 I Autoclave |Worker 1 J 1 _L 1 1 1 X. ILetter of 121.12.81 IDetaila In (Hr Frledel'. {Letter of 121.12.81 1 1 1 1 1 1 , 0 0 3 ^ fe oa o VVV 0 0 0 0 0 3 7 6 9 IMPERIAL CilEHICAI. INDUSTRIES FLC PETKQCtlEH I CALS AMU PLASTICS DIVISION LIVED Angloaartona Cates * (Huvtw Datei 20 January 1962) * Should thla ch* be removed from the Hal? H10S1I have It on their supplementary Hat relating to JS 1/6/77 Vega 13 I t 1l < I ** t( 3 4 I5 11 fJ { 1 11 1 1 COUNTRY AMD 1 NAME OR RATE OF 1 1 | REFERENCE 1 INITIALS | BIRTH 1 COMPANY ( FACTORY 1 HO ( 11 1 t f I| t 1 ( l1 1 1 ITALY I l 1 11 i oi i 1I (15.06.34 1 ( {(On NIOSH ( supple1 mvntary 1 1 let) 1 | | { ( I 11 11 1J I ( ( 1 t >1 11 t oz 1 1 1 (13.11.29 1 1 Montedison!Porto !t I 1t 1 03 I 1 1 1 (14.03.20 Salvay (Harghera 1 ( (Ferrara? 1 1 I (1 1 1( 1 1 1 i1 1 I 1l t I 1 ll I I 04 JBF (20.07.3? SC RavennaJRavenna 1 i (1 1 t t1 1 < 1 I1 1 { 11 1 1 i 1( ( i{ I \ t 11 l 1 11 1 ( i 11 1 t I 11 ( i 11 ( ( t (1 1 1 l ! 1 i 1 ( 1 <J J 6 FIRST VC EXPOSURE 00.00.65 00.00.57 00.01.53 00.04.59 1 7 19 L l DATE OF | ACE AT DIAGNOSIS | DIAGNOSIS 1 1 ( 19.04.71 1 1 ( 36 i i 1 1 1 1 1 (3.12.72 1 1 1 10.07.75 1 35 1 00.01.81 i t i i i 1 43 1 1 1 1 1 1 1 1 \ l 1 1 1 1 1 1 11 9 I 10 1 11 1 J_ J________ 1 12 1 11 YEARS OF 1 TEAKS OF | DATE OF 1 HISTOLOGICAL EXPOSURE TO 1 EXPOSURE ( DEATH 1 CONFIRMATION DIAGNOSIS \ 1 |1 t 11 )( 1 11 06 03 116.04.71 TYe. l1 l 1 1 ( i IS 06 (00.12.72 Tee 1 1 1 21 \ 2) (IO.Q7.7S 1l Tea 11 1 t1 I 11 \ 11 21 i 21 (30.03.61 Tea 1 tI 1 1I f i1 I J1 1 11 l 1l 1 1( ! 1i 11 1 11 1 11 1 1 1 (i 1 11 L J J_ 1 13 1 4 _J____________ 1 ESTIMATED ( EXPOSURE ( OCCUPATION LEVEL i 1 1 1 |PVC Bag (extruder J 1 1 1 i 1 (Polymarker 1 High 1 1 (Autocleaner (6 yra (Autoclave (operator 112 yra 1 1 12 yea - U yr Very High (Monomer 5 yr* - Medium (operator 1 (20 yre |Autoclave 4 yra - (operator 6 Low jollier dutlea (In auapena- |Ion poiywer- tlaatton. 1 (Area Foreman | In tut Dept (since 1975. J____________ 15 OTHER CAREER HIGHLIGHTS 1 16 ( OTHER COMENTS 1 1 | | 1 1 t 1 *1 Primary tiwer| may have hem j perlcardlia Not homogeneoua wit! other ceaee | | j j *FOA at el papers at Dubrovnik euggeat Ferrara? 1 1 1 1 l 1 | j j | | 1 1 1 1 1 * f J 1 1 1 1 l 1 1 1 I 1 IMPERIAL CHEMICAL INDUSTRIES PI.C PETROCHEMICALS AND PLASTICS DIVISION LIVER Angloaarcuaa Case* - (Review Date! 20 Junuary 1992) rat* I COUNTRY AND REFERENCE NO 2 NAME OR IT1ALS 31 1 1 DATE OP 1 BIRTH | 4 COMPANY (5 1 1 1 | FACTORY JAPAN 01 T' -ojl H`>i I 01.08.22 Mitsui Nagoya Toatsu (no coaieent by Jap PVC Asbuc) 02 02.08.39 6 FIRST VC EXPOSURE 00.04.53 00.11.58 7 DATE OF DIAGNOSIS 24.10.75 10.08.76 8 ACE AT DIAGNOSIS 53 37 9 YEARS OF EXPOSURE TO DIAGNOSIS 22 17 10 II YEARS OP DATE OP EXPOSURE DEATH 13 26.10.75 13 10.08.76 11 I 12 1 13 1 16 | J__________ JL 11 l HISTOLOGICAL | ESTIMATED 1 1 CONFIRMATION | EXPOSURE | OCCUPATION ( | LEVEL 1 1 J__________ 1 11 1 I 11 I 11 I Yea (PVC Assoc |13 yra auto-| |aaya not (clave |known. (cleaner | | Japan 11966 - | (Tinea (aealgned to | | Indicates (different | Ion 25.10.75|work alnce 1 leapoaurea (bed til | (often at |heelth | (3000 ppa up| | (to 1976 1 I 11 1 1( 1 Yea (Not known (In polyaer- | 1 flection work| 1 (Including | 1 lautoclave | 1 (cleaning | J__________ Jl 1 15 1 16 1 OTHE1 CAREER 1 | OTHER | C0FMBNT8 HICHLICIITS 1 1 1 1 1 (Japan Tlaea 125.10.75 6 IJapaneae PV |Aaaoc lette * (of 31.03.76 1 1 1 1 1 1 1 1 IJapaneae PV2 |Aaeocletlon (letter of (31.03.78 1 J 1 1 I 1 1 ! i i i i i i i i i i \ i i i ( i it i 00000377O 3 > > IMPERIAL CHEMICAL INDUSTRIES VI.C PETROCHEMICALS ANU PI.ASTICS DIVISION LIVER Aiigioea rcoaa Cases - (Review Date: 20 January 1982) Pate 19 10 12 13 14 15 16 COUNTRY AND REFERENCE NO NAMi: OR INITIALS DATE OF BIRTH COMPANY FACTORY PIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HICHLICHTS OTHER COMMENTS NORWAY 01 All 23.12.15 Norsk lleroyu no.03.50 21.12.71 56 22 21 04.01.72 Yea High Foreman 4 | Hydro Autoclave | aupervlaor | 1 1 1 1 1 1 1 1 1 1 1 1 (Confirmed by |Dr Thl1(Evanaon of b . {At APME HC| t |9 June 1978 |Hr P Rangnaa' (atated that H (had been a laeeber of a {atart-up tai . |VCH 6 PVC n< ca |aade in aaai (building, ''a |VCM vaa aad . (from acatyl.-a VVV (*1 Oo o o IHPKKIAL CHEMICAL INDUSTRIES II.C PETROCHEMICALS AN') PLASTICS DIVISION LIVER Anglussrcoaa Caeea - (Review Date; 20 January 1982) Pafa 16 10 12 13 14 IS COUHTKV AND REfERPHCE NO M'lit OR initials V:.tt OF BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO D1ACN0SIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOCICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS It OTHER COMHEHT8 SWEDEN 01 02 23.06.27 Kemanord Sundevall 14.08.51 20.10.70 43 19 16 20.10.70 Yea Polyvorker 27.11.11 Kenanord Sundevall 00.01.45 00.06.72 61 27 27 16.08.72 Yea High VCK production 01 NE 10.06.10 Keaanord Sundeval1 00.05.47 18.03.76 65 29 21 19.03.76 Yea (Ugh Polyworker 04 Al. 16.11.14 Keaanord Sundevall 00.00.46 12.05.77 62 31 31 12.05.77 Yea High 1946-1956 polyaec- laatlon worker (12 yre) 6 1958- 1977 foreaan 09 yre) Hr Sjoelln' latter of 28 March IS 8 conflraa BL waa a aonoa.<r worker who -a heavily expoaed, probably av*n sore ao tha- a noraal reactor cleaner In flrat I! yra of employment 'ad been heavily expoaed. ,r 1974, live abnoraallt/ and nacroa' < dlagnoaed. Data confl'aad In Dr D Ry~ea lettar 18.1.77 to CEF1C OS 12.03.19 Keinauurd Sundava11 11.05.64 22.11.60 61 16 16 22.11.60 Yea High - 1964-1970 6 Yeara centrifuge Lou - operator 10 Yeara 1970-1960 drier operator Latter of 2nd Mov 1931 f roa Dr David Bfvan VVV G 00003772 '-1 tttO O O O O . v. IMPERIAL CHEMICAL INDUSTRIES 1'1.C rETMocueHiCALS and i-lastics vision LIVER AnglcieertuM Cave* - (Review Out 20 .January 1982) UK Sheet I Page I? l 1 |2 |3 tf 4 (5) 6 )) t (COUNTRY AND 1 MANE 01 { DATE OP ( REFERENCE ( INITIAL-. t BIRTH COMPANY 1) ) FIR5T VC FACTORY | EXPOSURE NO I 1t 1 iI t 1l ( UK 1 ! 01 IWJ (20.04.01 fCI )1 (HlUhou ee I 04.04.44 ( 1 ! 1j ) i 1I 1 1i 1 )i l 1i J 1i ( 02 1 1i 1i 1 1i 1 1\ 1 03 JBJW J02.06.37 ap 1 (Barry i i 00.02.66 1 ti J 1i > t 04 IJSA 123.06.20 ICI 1i lj 1H1I!houe| 26.04.34 l )t 1 1 t 1i 1 ti 1 1\ J )i t (i ( It 1 1) 1 fi < 1i 1 1i 1 1i 1 1i 1 )i 1 1f 1 ti 1 Ii I 1i 1 Ji It 1) l _____L _ . JL i 7< 8 1 t1 9 ) 10 ( H 1 12 1( 1 I 13 1 *4 1 15 1 16 | | 11 11 \ 1 1i 11 DATE OF { ACE AT YEARS OP l ykaks OP { DATE CF ( H18TOLOCICAL ( ESTIMATED 1 DIAGNOSIS | DIAGNOSIS | EXPOSURE TO { EXPOSURE { DEATH 1 CONFIRMATION ( EXPOSURE | OCCUPATION ) I DIAGNOSIS l it LEVEL 1 I OTHER CAREER HIGHLIGHTS 1 1 | t OTHER COtttENU 1 2 1 I 1 1 11 I 1 1f 11 1( 1f 1 1 1 i i i 03.12.72 (For 6 1 \ 1 Collier ( paper aaya) 23.12.72) ( 1 71 1 )1 28 ) 22 (03.12.72 ) Tee t Fo*4 ) (Collier { 1 (paper ( 1 (aaya { ( (23.|2,72)| 500 ppw t1 (1944-7 VCM 1 (1947-8 Drier! (1948-61 t (Autoclave (operator (1961-66 1 1 ( 1 1 1 1 1 1 l i i i i fc i t 1 1 11 (Drier 1 i ( | )i 11 1 i t 1i 1 1 i 1 l 1f 11 (Dubloua i 1 11 f1 (fahricetloc i 1 11 (1 (ceee i t1 \) ( _i 1 00.12.74 ) 37 1< \( 09 3.5 (24,12.74 ) '{* High (Autoclave 1 1 (Eapoaure i i 1 ii (cleaner 1 (Halted to r 1 1 11 (1 (2.66 - 9.69 i 1 t1 1 1 i 00.06.79 1 | 1 1 5*? i 1t 25 \ 18 (12,(0.79 ) \An \ 11 1 f1 Hedltar high 1 (54-5 (Bagging (Plant 1 (Pre-war flab (packer (1939-45 aray ( 1 1 1 t i t t 1 ( 11 (55-6 (vehicle 1 i 1 1 1t ) 1 11 l 1 i( 1 1 1} ! t 11 1 1{ (Drier Plant (56-58 (Autoclave (worker (56-61 |Chargehand (Maintenance (1945-54 (fish necker 1 1 t 1 1 ( 1 1 2 3 2 1i 1 1 ti (Drier 1 l f 1 ) (1 1 1 11 (Plent (61-72 ( 1 1 1 ! ) 1 11 (Fortetn 1 f i ) I 1( |C 2/3 Plent 1 l i ) !1 1 1 1 \ t 1 1I 11 1 i 1 1 tt il 1 1 1 )( 11 1 1 t( l 1 1 It 1 1 11 i - J. t < IMI'KHIAl. CHEMICAL INDUSTRIES FLO PETKOCItEHicals and plastics division UK Sheet 1 Pegs 18 LIVER Anglos.ircoaa Caeca - (Review Date! 20 January 1982) 11 12 131 4 |5 617 a 9 io 1 il 12 1 13 1 14 15 1 11 |COUNTRY AND | NAME OR | DATE OF 1 j REFERENCE | INITIALS | BIRTH | COMPANY 1 1 | FACTORY 1 NO | UK t os 1 1 | JK 11 11 130.03.14 | BP _| 1 [Barry X 1X 1 FIRST VC DATE OF ACE AT YEARS OF YEARS OF | DATE OF HISTOLOGICAL | ESTIMATED 1 EXPOSURE DIAGNOSIS DIAGNOSIS EXPOSURE TO EXPOSURE ) DEATH CONFIRMATION | EXPOSURE | OCCUPATION 1 X X X DIAGNOSIS X J L level 1 | 1 00.01.51 00.10.79 65 28 21 (19.11.79 11 1 1 |1951-52 1 OTHER CAREEI HICHLICHTS 1 11 I 11 1 11 1 11 11 1 11 11 1 11 1 11 1 11 1 11 I 11 1 1l 1 1 1 1 1 1l 1 1 1 1 1 l (Polycleaner \ 1 1 11952-53 1 1 |Utei 1 1 1 (1955-60 1 1 jPolyfloor 1 1 1 11960-64 1 1 (Poly 1 1 1 (Chargehand 1 1 1 11964-70 1 1 1 (Charging 1 1 1 (operator 1 1 11970-72 1 1 l1 1 1 (Drier l 1 1 | 06 (CEP 1 1 t 1931 1 1 1 BP 1 1 | Barry 1962 09.01.80 48/9 X 18 X 12 1 1, 109.01.80 1 (operator 1 1 1, | 1 17 yea l 1 11 1 i1 1 11 1 1 1 1 1 (Poly Floor 1 1 (Operator I 1 1 15 yra 1 1 I o; (KB 1 1 | 1920 1 1 t BP 1 1 IBarry J. 1963 00.00.80 60 17 { JX 113.06.80 1 ICreaaer on 1 1 IPoly Floor | 1 IFolycleaner 1 1 11 1 11 1 11 1 1 1 1 1 11963-5 1 1 1 (Recovery 1 1 1 11965-1971 1 1 1t 1 1 11 1 1 I 08 |WTH 1 1 l 11 108.05.24 1 BP 11 11 11 I (Barry 1 1 1 19.09.50 24.11.81 X 37 31 l 24 125.(2.81 1 1 11 11 | I 11950-51 1 1 |Autoclave 1 1 (operator 1 1 11951-1937 l 1 1i 1 1 1 iChargenan 1 1 11 1 )1 1 ) I1 ) 1 (autoclave 1 1 (building l 1 11 1 1 1 11957-1974 1 1 1 11 1 1 l 1 (Shift 1 1 1 (supervisor l 1 11 1 11 11 1 1 1 1 11 1 1 Isutoclave 1 1 (building - 1 1 (Never l 1 11 1 11 1 1 1 1 leleaned 1 1 1 * (autoclaves 1 I l1 1 11 ) 11 1 1 1 11 1 1 1 (but 1 1 laupervlaor'i | 1 |job entailed|. 1 11 l 11 l 1 1 (entering 1 1 ' <j lautoclevea 1 1 11 1 1 1 (to inepect 1 1 ll 1 \ 1 1 | then 1 * 1 X ... LX X X X 1X LJ X i 18 1 | OTHER | COttlENTS 1 1 1 1 1 | 1 * 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |Death (attributable Ito VCM (Angloaarcoac I Incidental 1fIndian 1 1 ( ( 1 1 1 1 1 1 1 ( 1 1 1 1 l 1 1 1 VW 000003774 ! W V 000003775 IHI'^KIAL CHEMICAL INDUSTRIES FIJI petrochemicals and plastics division LIVER Aitglosurcnna Cases - (Huvluu Date* 2D January 1902) *UK *)(( of date* DAY - HOHTII - YEAR USA Stott I Page 19 i 12 13 14 3 I 16 COUNTRY AND REFERENCE NO NANS OR INITIALS DATE OF BIRTH USA 01 Earl Parti I 7.10.23 02 19.08.33 03 Edu,- rd 25.05.15 Dln.-lddle 04 15.01.24 COMPANY BFC BFG BFC RFC FACTORY Louisvilla Louisvilla Louisvilla Louis ville FIRST VC EXPOSURE 09.12.40 13.11.35 20.11.45 06.07.52 DATE OF DIAGNOSIS 03.03.73 00.05.70 19.12.73 19.08.67 ACE AT D1ACNUS1S 49 37 56 43 YEARS OF EXPOSURE TO DIACNOSIS 24 14 20 15 TEARS OF EXPOSURE DATE OF DEATH HI6T0L0C1CAL CONFIRMATION 21 03.03.73 Yes 13 27.09.7) (NIOSH ays 28.09.71) 28 19.12.73 Yes Yea 13 07.01.68 Tee ESTIHATCD EXPOSURE LEVEL OCCUPATION Pot Cleaner (Block Jaaa 1974) p 53 Pot Cleaner (Cf Block) OTIIE8 CAREER HICHLIOITS I | OTHER COMMENTS ____________ L I History given IRolllng Sto In Annele NY |Art ACAD SCIENCES |Ref I NT Ac Vol 329 (1979)|of Sc Syap poge 190 in |1974 Paper by |Alao Hock B R Cottloe of|Jaea 1.7.74 OSHA |p S3 i_______________ I I Ref 1 |Also Block | JAMA 1.7.7* Ip 53 Pot Cleaner (Cf Block) Louisville Courier Journal 02-09-80 Pot Cleaner (Cf Block) I |Ref L | Also Block I J______________ I |Raf 1 (Also Block 05 25.01.12 BFC Louls- 19.06.44 09.04.64 52 20 20 09.04.64 Yes V1111 06 Ray 23.11.28 BFC Louis 17.01.62 00.02.74 43 12 12 24.07.75 Tee Austin Jon .n't ville 07 Charles 03.05.22 IfCC T-Jeart S Charle 27.OB.44 ston 00.00.68 45 24 23.03.68 Tea 00 06.05.20 Goodyear Niagara 07.10.46 00.06.61 41 15 29.08.61 Yea Pot Cleaner (Cf Block) US Air Force Pot Cleaner (Cf Block) | Ref 1 |Also Block J_______________ I |Ref I + (Louisville ITlace 23.7,73 (Retired April 11974 (Also Block t I (Ref I ____ I J______ I I Ref 1 I IMPERIAL CHEMICAL INDUSTRIES Pl.C PETROCHEMICALS AND PLASTICS DIVISION LIVER Angloearcoua Caaea - (Review Dale! 20 January 1902) *UK lyatca of dates DAY - MOimi - YEAS USA Sheet 2 Page 20 10 II 12 13 14 IS 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF 0IRTII COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIACNOSIS YEARS OF EXPOSURE TO DIACNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREEI HIClILICJ. TB | OTHER COMMENT 1 USA I 09 Rayaond 08.11.11 BEG Loule- 28.OS.45 01.03.74 43 29 24 11.03.75 Yea 2000 ppa Cettle- vllle FlngerT |Ref 1 hae (wrong flgur Ire flrat lexpoaura. ILouleville |Tiaee |29.10.74, 112.3.73, 110.3.76 10 16.08.13 Goodyear Niagara 12.06.51 00.05.68 55 17 V 10.05.68 Tea I * f I 27.OS.09 Goodyear Niagara 14.10.46 00.03.70 61 23 23 16.03.70 Yea X I |Ref I I 12 Francis A 17.11.18 FI reslone Fottatown 13.07.49 02.05.69 50 20 19 02.05.69 Yea High 10 yra 10 yra aa Utility k | Ref I + la ho chraan Pa reactor op. Service op. | o f 26 Apr 1 (not cleaner Dagger 11978 fro* - aeparate Dryer op. |Ruaaall A ,'nrk crew cleaned Stripping op, | to J T Sea Mil autoclavea) 3 yra prior |of MCA aervlce la tyre plant 13 Richard 01.12.21 UCC S Charle- 11.12.42 00.05.74 52 32 26 07.04.74 Yea 2000 ppa Edward etoit Clendenlti 14 IS I Charleston (Dally Hall (21.7.75 J___________ I ItKibloua | f abrleatlci (cam* J__________ ( |Dubloue |fabrlcatlo: |caae ! :> > 000Q377b 111 ' I-' KIA ( CHEMICAL INDUSTRIES Pl.C PETROCHEMICALS AND PLASTICS DIVISION LIVER Angiosarcoma Cade* - (Review Date! 20 January 1982) UK Syetea of dates DAT - MONTH - YEAR USA Sheet 3 Pag* 21 10 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF R1RTII COMPANY FACTORY FIRST VC EXPOSURE USA Jaaee IluVe rj 04.11.27 BFC Loulevllle 08.05.50 17 Peeienbooa 06.05.31 EEC Louis ville 23.06.55 18 Charlie 22.04.28 BFG Arthur Avon Lake 15.09.54 19 Virgil 00.00.15 UCC ChrlatIan S Charle 00.00.43 ston 20 31.08.17 Coodyeer Niagara 00.00.55 21 Chester 02.09.09 UCC IMi-kte S Charle 00.12.46 ston DATE OF DIAGNOSIS 00.00.69 II.10.74 00.00.75 19.06.75 30.01.76 Early 77 ACE AT DIACN0S13 41 43 46 60 58 67 YKAKS of EXPOSURE TO DIAGNOSIS 19 19 2| 32 21 30 YEARS OF EXPOSURE DATE OF DEATH 04 27.03.69 19 16.10.80 M 02.|1.75 32 06.04.76 18 >0.01.76 22 02.01.77 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER I HICHL1CHT8 | ____________ L OTHER COMMENT- tee Yea on 11.10.74 but no poet-norten 16.10.80 Yes Yes Yea Yet 1951-4 VCK polymer isation 13 yra Navy autoclesner 8 yra on Eatol Tyre Store plasticiser 4 Carboset operation 2000 ppa Proa 1954 I |T*bla 4 in onwards In |Uagoner Aray and other|TeetIvony *.-> service. 46-50 Aray (US Senate |Conflrad U |M N Johnso. |ltr 07.08.1 ___________________ I_________________ I Dr H N Joh eon lletter of 124.2.61 co if lraed dee .h (6 yeare ef er (diagnosis_______ I IConfiraed o |H N Johnso |1tr 07.08.18 |Also Rolllrg IStone aeg. IIS.01.76 I J. 1 |Ullllaaapctt (Sun Gault 121 June 19 5 (Charleetoi (Dally Mai; Ul.7.75 X I INIOSH let:ar lof 25.10.1 X I (28 yrs wit* (UCC at SC |Retired |News tele Are 123.2.77 J____________ P** Pv fv m oO o o Q > IHI'KHIAL CHEMICAL INDUSTRIES PIC PETROCHEMICALS AND PLASTICS DIVISION LIVER Angiosarcoma Cases - (Review Date! 20 January 112) *UK system of dates DAY - MONTH - TEAR USA Sheet A Pag* 22 1 11 1 12 | )1 _l 1 (COUNTRY AND | | REFERENCE | _L J 11 NAME OR | DATE OK 1 INITIALS | BIRTH | NO 1 1l ;USA 1 1 11 11 4 COMPANY |5 | FACTORY 6 FIRST VC EXPOSURE 1 7| 0 DATE OF DIAGNOSIS L 1 | ACE AT I DIAGNOSIS 1 . . ............. I. 1 9 TEAKS OF EXPOSURE TO DIAGNOSIS 22 n 24 (25) | 1 1 1 1 1 1 1 1 1 l 1 1 1 1 1 1 1 1 1 1 1 | Charles |Kdw* rd | rt>ore 1 1 1 1 1 1 1 1 I 1 1 1 1 1 I 1 1 1 1 J (02.10.23 { BKG (Louis- 11.07.47 00.01.76 | 52 29 1i Ivllie 1 1 1i 1 1 1( 1 1i 1 11 1i 1 1i 1 1i 1 1i 1i 1 1 (i 1 1i i 1 1 1i t ii Ii 1i 1L |C:,.Ofl.23 | Crest 1I 1| 1 11 fTosTTT | American Cheeicsl Cooipflnr ucc i1 l1 l( |Fitchburg |rtss. |S Qiar 1 e| stun 08.09.50 1939 1 1 1 06.04.73 27.05.77 | 1 1 1 | 1 1 1 50 60 15 38 l1 l1 I1 11 l1 l1 1 1 1 .1 1 1 l1 11 I1 1 ( 1 I1 (1 1 1 11 L -1. 11 1 1 1 1 11 1 1 11 1 | Removal from ret leter conf rrard In R Kaminski letter of 5 November I960 11 1 _L 11 1.1 10 11 YEARS OF | DATE OF EXFUSURE DEATH 28 |0'< .12.76 | 1 14 |C5 .04.73 24T (Nll)SH eaya 26) | |2? .05.77 11 1( 12 1 13 1 14 1 15 t 16 ( 11 1 1 1 HISTOLOGICAL | ESTIMATED 1 1 1 OTHER 1 I OTHER I | CONFIRMATION | EXPOSURE I OCCUPATION CAREER | COMHEMTS | t LEVEL 1 | HIGHLIGHTS 1 I 11 1 1 11 1 I 11 1I Yes (1 |Louisville ( 11 (Times 26.1.'. > | 11 |sald he was | 11 (the 10th AS | 1 1 |victim at | IBells Lane f j 11 (whom 8 had | 11 (died by .| 1( (26.1.76 | 11 (In bis lett* r | ( |of 16.09.81 | 11 |Dr M N Johntanl 11 (confirms this | 11 (Is the | 11 (case descrltad| 11 (by Dennaher | 11 1I (Taaburro & ' tm| (In Feb 1980 | 11 (Am J Medici. S | 1 IVol 70 p2S0 I Yes 1 1 1 I 1( 1 | 11 1 | Cholanglo- t1 (Hedlin to (1941-65 non-(1937-39 was I IN H Wheeler 1 | sarcoas (R Kaeloski 26/2/79) (high for 12A yra (eolvent (off and on (vinyl resin (labourer (unit and (1939-41 may (letter of 118.8.77 to (J Stafford | | j (dispersion (have been lalvas detail's 1 (vinyl realns|expoaed as (Rose Kanins' 1 ( (unit first Iresc tor (letter of | (as fitter Iclesner 126/2/79 1 (helper, then|!943 becaee |R Kaminski | (shift Ishift fitter |(5 Nov 1980) | (utility man (1946 became (suggest* thit | 1 Ishift utility (N10SH will | 1 |a*n (retain on | 1 126.04.65 (register since! 1 1 11 leeployment was|thls neoplies | (terminated 0(may be es* 'l-| 1 (eted with ASL.I 11 11 11 11 11 11 J _J |8 N Wheeler | (letter of | 120/2/79 and | (Rose Kaalnf'xl | (letters of (26/2/79 aik } j 15/11/80 | W V 000003778 IMPERIAL CHEMICAL INDUSTRIES PLC PETROCHEMICALS AN!) PLASTICS DIVISION LIVER Angiosarcoma Caaea - (Review Date: 20 January 1962) `UK ayatea of datea PAT ONTH - YEAR USA Sheet 5 Pag* n 1 (2 1 | )1 11 COUNTRY AND i NAME OR 1 DATE OF REFERENCE | INITIALS | BIRTH NO (USA 1 1I 1 4 COMPANY 1 5| 6 7 tX 1 FIRST VC DATE OP FACTORY | EXPOSURE 1 DIAGNOSIS 1 ( 26 |John Berry|Q7.07.23 BFG (Louis- | 03.10.47 11 Iville | I1 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 l1 1 1 27 |J L 1 III.05.I6 UCC 1 |S ctiarle-l 01.07.41 I For reel 1 ton | 11 1 11 1 11 1 11 1 11 l 1 28 1 1 a!i #( UCC 1 |S charle-l 00.08.4a 11 I ston | 1 29 ( 1 1 (12.10.01 1 UCC 1 |S Charle-| 00.05.42 ton | 11 11 1 30 | UVM 1 122.02.22 Tenneeo 1 |Flealngton 11.06.64 11 Chemicals | 11 t1 11 1 11 11 11 11 11 11 1 31 l 1 (08.11.23 UCC 1 |S Oisrle-I 12.05.46 11 ton | l1 11 1 (1 11 11 11 t1 l1 11 11 11 1 11 11 11 11 11 11 1 l 1 1 _ .1. _________ 1 l1 1 1 L. _L 1 11 1 1 1 00.00.77 (up to 2 years after death) 30.11.78 o 3 li iTJa' 00.03.80 30.12.80 01.08.81 8 ACE AT DIAGNOSIS 11 9 1 io 1 11 11 12 1 13 | 14 | J1 TEARS OP | YEARS Or | DATE OF 11 HISTOLOGICAL | ESTIMATED I . EXPOSURE TO | EXPOSURE | DEATH CONFJ NATION | EXPOSURE | OCCUPATION DIAGNOSIS J 1 JX 1 1 LEVEL 1 1 1 13 OTHER CAREER HICHLICHTS 1 1 1 | I 1 16 OTHER COWIENT 1 | 1 | | 1 52 (death) 62 61 72 58 57 28 ( 18 111.02.75 (death) 1 1 11 1 11 11 11 11 11 11 11 11 11 1 1X 37 | 20 (25.11.78 |(NIOSH 1 Isays 27 1 land C 1 |Dally Kaill 125) 1 \1 1 {(13.11.76 34 1 33 11 11 38 1 16 101.03.80 (1 11 1t 16) 1 15 130.12.80 11 11 11 11 11 11 11 35 1 >3 |Allve 11 11 1t 11 11 l1 11 11 11 11 11 1 11 11 ________________ _________ i . 1 T ' ? TC9 Yea lee Yrs Yea 1 (Exposed In IVarloui Jobal (some degreelln PVC | | to 22 Iplanta froa | |R Kaalnakl |letter of 126/2/79 ard | | | Ichenlcala (but aain lexpoaure Icold rooa to| jpaate | Irecovery to (Prof. Taafcurrol I letter of | 19/1/79 | |waa to VCH |PVC charging! 1 |probably loperator to 1 Ihlgh Ipaate | 1 1 Icharging. 1 1 1111 August | 1 1 11965. 1 1 (Terminated | i 1 leaployaent i J 1 Jan 1966 | 1 High (Operator to (Exposure In |R N Wheele 1 110.10.76 |bulk and | ltr of 4 J*tt 1| (dlaperalon PVCI1979 and 1I laanufacture ICharleaton 11 (Dally Hall l1 1 130.11.76 o i 11 1 |R Kaalnekl 11 1 126/2/79 11 |R Kaalnekl 1 I I I 1 | i i | j | | \ | | | | 11 1 11 11 t 1 1I 1 11 1 J J____ 1____ _______ __ (6 ** Unknownltialntenance ( |9 - Minimal (Mechanic | |letter of 16/4/79 | 1 |R Kaalnakl ( 1 Letter# of | |19th June . 980| 14 5th Nov 9601 11 11 1 16 yra 1 1 1 1 |Elnevhere | 1 1 1 1 1 1 (High (But 1 It yra I (Boiler house| (Operator ( (9 yra | |Chemical (Froa 1959 to 1 1 1 I Dr Dacey 1 1 1 | |not aa hlgh|Operator In 11976 Aliphatic (letter | (ae reactor Icharge |Chemical a 116.10.61 ad | [cleaner (reactor (operator and |R N Wheele | (would | (experience' | (Worked ae | | labourer I froa (June 1941 | | ( |to May 1946| land may 1 I hove 1 Iclenned 1 Ireactora ln| |froi July I976|letter of (to date |Foreman 19.11.61 1 |Allphatlc 1 lChemical 1 (Operation 1 |1 11 1 1 |1 l | 1 1 1 1 1 1 1 1 Itliat tine 1 I 1 1 VVv 000003779 IMPERIAL CHEMICAL INDUSTRIES I'l.C PETROCHEU I CALS AND PLASTICS DIVISION LIVER Angiosarcoma Cases - (Review Date: 20 Junuary 1982) Pag* 24 COUNTRY AND REFERENCE NO X NAME OK INI"1ALS DATE OP 81RTH COMPANY 10 12 13 14 PACTORT FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT UIACNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION EST1MATEO EXPOSURE LEVEL OCCUPATION 15 OTHER CAREER HICHLICHTS 16 OTHER COHHENT' YUGOSLAVIA 01 05.04.14 Jugo Split 00,00.53 08.04.73 59 20 20 08.04.73 Yea Vinll SAR1C et al paper Env Health Perspective Vol 17. pp 189-192 1976 02 15.11.31 Jugo Split 00.00.50 12.07.73 42 23 Vinll 12.07.73 Tea* 03 21.12.31 Jugo Spl It 04.06.54 i 1.01.76 45 22 22 l|.01.76 Yea* Vinll VCM Production VCM Production *In hla le ter of 3 Oct 1 78, Dr Splrtaa of N10SH changed the statu* of Caae 02 to VCM production employee. Dr Spirt** also notlf ad new Casa D3 elao VO productlor worker 04 I 1.06.30 15.12.58 03.09.78 48 20 I* 03.09.76 Yea Roee Kealn kl Letter of 19th June 980 VVV G 0000378G m CM HI CkO n Om In c id e n c e o f ASL Cases P er Annum The 1977 t o t a l In c lu d e s US c a s e 24 w h ic h I s a C h o la n g io s a rc o m a . -n -- O -- -- -- O--> pa in Ci loi I e2 O c E Ui v 0) o 3 CJ c n a> o u 3 X o as cc 0) *3 3 V C mx m o aj ci o m n n tf mioscoffiO-N en. ^iniorxcoffiO- 1*1in I-- CO cr> C> 3 C c VVV 0000037Q1 0 0 0 0 3 ?82 Distribution of ASL Cases by Country USA W Germany France Canada UK Sweden Yugoslavia Ita ly Czechoslovakia Ja,oan Be lgium Norway 28 *** 21 ** 14 10 7 5 **** 4 ***** 3* 2 2 1 1 TABLE 2 Total 98 * Omit ItOl - atypical case of PVC bag extruder* ** Includes GE03 aerosol can filler* *** Includes case US 24 which was diagnosed as Cholanglosarcoma & US 3J who la ALIVE **** Includes one monomer worker* ***** Includes two monomer workers* l,.e Western Europe North America Rest of World 52 38 8 Total 98 Page 26 i y Pattern of ASL Cases by Factory TABLE 3 (a) W Europe Of the 52 cases In W Europe, 42 have occurred In clusters at 10 factories. Of the 21 German cases, 18 have occurred In clusters at 4 factories. ASL Cases Kemanord, Sundsvall PCUK, Brignoud Dynamit, Trolsdorf Chloe Chimie (Formerly RP), St Fons Wacker, Burghausen CWH, Marl ICI, Hillhouse BP, Barry Solvay, Tavaux Lonza, Waldshut 5 5 10 5 4 2 2 5 2 2 42 Page 27 NB: There are 31 pre 1962 PVC plants in W Europe; 10 of these have had ASL cases (Ref Table 8) (b) N America Of the 38 cases In N America, 34 have occurred at four factories out of a total of 49 factories - in N America 41 plants have not had ASL cases. ASL Cases BFG, Shawinigan BFG, Louisville UCC, S Charleston Goodyear, Niagara 10 11 9 4 34 NB: There are 29 pre 1962 PVC plants In N America; 8 of these have had ASL cases (R^f Tables 9 & 10) (c) Rest of World The 8 ASL cases are believed to be in 1 cluster of 4 and 2 clusters of 2 cases. VVV 0 0 0 0 3 7 fl3 TABLE 4A Latency Periods (Years from first Exposure to Diagnosis) W Europe No of Cases Total Years Belgl iro 1 18 France 14 336 Average 16 24 * Page 28 Germany Italy 21 362** 17.2 * 3 58 19.3 Norway l 22 22 Sweden 5 122 24.5 N America UK 7 156 22.3 52 1074 20.7 Rest of World US Canada 28 685 24.5 * 10 204 20.4 * 38 889 23.4 Czechoslovakia 2 31 15.5 Japan 2 39 19.5 Summary Yugoslavia 4 8 85 21.2 155 19.4 W Europe 52 1074 20.7 N America 38 889 23.4 VVV 0 0 0 0 0 3 7 8 4 Rest of World 8 98 155 2118 19.4 21.6 * Of the countries with > 10 cases. France and USA have average latency period above world average and Germany well below. ** The latency periods stated by B G Chemle for German Cases 20, 21 6 22 have been used* Even If onedeclded the latency period should In these three cases run from the first exposure to death, the average would still be low at 18.2. TABLE AB Page 29 Re Lgium Canada Czechoslovakia France Germany Italy Ja pan Norway Sweden UK USA Yugoslavia TOTAL 11 11 1 o -9 yrs | 11 I1 11 11 11 11 1l 11 11 11 1I 11 11 11 11 11 11 11 1 1| 11 1l 11 11 I1 11 11| |l 1 1 10-14 yrs J 1 1 1 1 1 31 1 I 1 1| 1 7** | 1 1 1 f 1 1 I 1 t 21 1 1 1 1 13 | 1 15-19 yrs 1 L| 21 AI 71 1| 1| 21 2I 7| 27 | 1 1 20-24 yrs 1 1 5 2 6* 2 1 1 7 4 28 1 1 1 | 1 1 1 I ! | 1 1 1 | 1 | 1 1 t 1 1 | 1 1 1 1 | 1 25-29 yi 2 4 1 2 3 4 16 1 1 II I 1 30-34 yrs II Average 35+ yrs | Total II Latency 1 1 II Period 1 1 |l l 1 II i 1 1 II 18 1 1 11 1 1 10 II 20.4 1 1 11 1 1 2 II 15.5 1 1 11 11 21 14 II 24 1 1 11 1 21 II 17.2 1 1 11 1 1 3 1 1 19.3 1 1 11 1 1 2 II 19.5 1 i 11 1 1 1 II 22 11 11 1 11 1 5 II 24.5 1 l 11 11 1 7 II 22.3 1 i l 11 14 4I 28 II 24.5 1 1 1 11 1 1 4 II 21.2 | I 1 l| 1 1 11 1 71 6I 98 II 21.6 _L L * Includes G 03 aerosol can filler ** Cases 20, 21 and 22 have latency periods of 12, 13 and 11 as given by the BG Chemie. There may be problems of definition here - were these cases actually diagnosed as ASL in 1974, 1974 and 1972 respectively and lived until 1980, 1980 and 1981? VVv 000003795 TABLE 5 Page 30 Annual Incidence of ASL Cases (Date of Death) by Geographical Area 1955 7 1961 2 4 6 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 Total 11 1 Western Europe I 11 11 J1 11 11 11 1 11 1 | 11 11 | 11 | 11 1 14 1 11 | 13 1 16 I 16 I 16 I 17 15 | | 16 I 14 l 1 52 * | North America 1 1 1 1 1 5 2 1 2 1 4 2 4 3 3 2 - 3 -** 37** | Re; >: of World |1 12 I1 |l 12 |1 I | | 18 1 | Annual Total 1 |1 11 i1 |1 |1 |1 11 |5 i3 12 13 |5 17 16 1 11 1 11 19 I 10 |5 19 14 I 97** * Includes G03 aerosol can filler but omits It 01 bag extruder ** Does not Include US31 still alive. < < < 00000 Page 31 TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING IT01) 1 KEY | EVENTS 1 WESTERN EUROPE 1 I NORTH AMERICA I 1955 6 7 8 9 1960 1 2 3 4 1 1 Cl 1 1 C2 1 1 1 I US8 1 C3 1 1 US5 j iViola 5 l 7 8 9 1970 i 1 El 1 G1 | Swl 1 1 l 1 C4,C5,US4,US7,US10 I US12,US16 1 US11 IMaltoni 1 Goodrich 1 | G2 2 | N1Sw2,UKl,It2 3 I G3** 4 1 G4,G5,UK3 5 | F2,F3,G6,G7,G8,It3 I C6,US2 1 C7 1 C8,US1,US3,US23 1 C9,US13 1 US6,US9,US18,US26 6 1 Bl,F4,F5,F6#F7,Sw3 7 1 F8tF9,G10,Gll,G12,Sw4 1 US19,US20,US22, I CIOtUS21,US24* 8 I F10,F11,G9,G13,G15 I US27,US28 9 1980 1 I G16G17 1 1 F12,F13,UK4,UK5,G18 1 ! UK6, UK7,G19>Sw5,G20,G21 I US17, US29, US30 I It4,F14,UK8,G22 1 1 Total 1 52 I I 37*^* 11 i | REST OF WORLD 1 1 1 1 1 1 1 1 1 1 1 1 1 Cs2 1 1 ! 1 1 1 Y1,Y2 1 Czl I Japl 1 Jap2,Y3 1 | Y4 1 1 1 1 1 1 18 ! * Cholangiosarcoma ** Aerosol Can Filler *** Does not include US31 still ALIVE PJST80061400,1-WPX7-2 000003187 VVV Page 32 TABLE > ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING IT01) KEY | EVENTS | f 1 I WESTERN EUROPE 1 1 1 NORTH AMERICA 1 I 1 REST OF WORLD| I 11 1 1 1 1939 1 1 US24* 1 I 40 1 1 1 1 Frll 1 1 C3,0S27 1 1 1 21 1 3 1 Frl4 1 4 IUK1 1 5 |Sw2 1 6 |Frl,Fr3,Sw4 1 7 1 Sw3 1 8 |Fr9 1 9 |Frl2,Fr4 1 50 |Fr7,Nl,UK8 1 US13, US29 1 1 C2.US19 1 I C1,C5,US5,US7,US28 1 1 C4,US3,US9 1 | C7,C9,US8,US11,US21 ,US31*** 1 C6,US22,US26 1 1 US1 1 1 US12 1 I US16 |Y2 r 1 1 |Svl,UK5 I 2 | G3** } 3 |G15,It3 1 4 |G7,G8,UK4,G19 1 US10 1 US4 1 CIO 1 US18 | Cz2 1 1Japl,Yl !Y3 1 5 |Gil,G16,G18 1 6 [FR10.G1 1 7 iFr8,G4,It2,G2 1 US2,US17,US20 1 1 1 1 IC2I 1 8 |Fr6*Bl 1 9 |Fr2,It4 I 60 |G5,G13 1 US23 1 1 1 Jap2,Y4 1 1 1 1 |G9,G10,G12,G17,G20 ,G22} C8 1 2 |G6,UK6,G21 1 US6 1 1 1 3 |Frl3, UK7 ! 4 1 Sw5 1 5 1 Fr5 1 6 IUK3 l 7I 1 81 1 91 Viola 1 70 t 1 1 US30 1 1 1 1 1 1 1 1 1 1 ! 1 1 1 (ill I 1 2i l 1 I1 11 Maltoni ! 31 1 I 11 i Total 152 1 I 38 1 18 11 1 * Cholangiosarcoma ** Aerosol Can Filler *** US31 is still ALIVE PJST80061400,2 WPX-2 ooooo^83 Page 53 TABLE 8 -WESTERN EUROPE PVC PRODUCERS - START-UP DATES vs ASL CASES (OMITTING G03) I START-UP | COUNTRY NAME j COMPANY NAME I LOCATION ] ASL CASE YEAR 1 1 1940 I United Kingdom IICI 1 [Rillhouse I NUMBER [01,04 1941 I France 1Rhone--Poulenc I St Fons 103,09,10,11,14 1944 [West Germany [BASF 1Ludwigshaien 1 [West Germany IWacker IBurghausen 104,07.11,15 o o foO oCM oH 1945 [Sweden 1Kemanord 1SundsvallC Stockvik) [Switzerland ILonza ILalden (Visp) 1946 1 Prance 1 Rhone--Poulenc 1Rousillon 101 1947 1 Italy 1 Montedison 1 Porto Marghera 102 1948 [United Kingdom I BP Chem [West Germany [Huls [Barry [Marl [03,05,06,07,08 [09,10 1949 1 Belgium 1Solvic 1Jemeppe 101 1950 [France IPuk IBrienoud 102,04.05.06.12 [France 1 Rhone--Poulenc 1 St Auban 107 [Holland [Shell ]Pernis 1 i 1 Norway 1 Norsk IHerova 1 01 1951 lItaly [Montedison [Brindisi 1 1952 [Italy [Montedison [Temi 1 1953 [Austria [Halvic [Hallein 1 [France 1Solvic 1Tavaux [08,13 [Italy [Solvic [Ferrara I 03 1 Spain ]Rio Rodano [United Kingdom1BIP 1Hernani 1Aycliffe 1 I IWest Germany IHoechst 1954 [West Germany |Dynamic 1Gendorf [Troisdorf 1 18 [01,02,08,12,16 1 1 117,19,20,21,22 1955 ]Spain [Monsanto Iberia[Monzon 1 1956 1 Spain ICaiqsa iSabinanigo 1 1 [Hisoavic 1Torrelavega I 1958 IWest Germany 1Solvav 1 Rheinberg ! 1960 [Italy 1S C Ravenna [Ravenna |04 1962 [Portugal !Cires [Oporto ! IWest Germany ILonza [Waldshut [06,13 1965 [France [Rhone-Poulenc [Montlucon [Italy IPozzi [Ferrandina 1 [West Germany IWacker 1966 [West Germany IHoechst S Cologne 1 1KnapsackC Frankfurt) 105* 1967 [France IAT0 Chimie t Balan 1 1 Spain IRio Rodano [Miranda de Ebro ! iGreece 1968 [Belgium [Esso Pappas IBadiphil 1Diavata Salonika [Antwerp 1 1 1969 [United Kingdom[Vinatex 1Staveley 1 1 Italy IRumianca [Cagliari Sardina 1 1970 1 Italy [SIR [Porto Torres Sar 1 [United Kingdom!ICI [Runcorn 1 1971 [Italy 1 Spain [Sweden 1S C Ravenna IHispavic 1Kemanord 1 Ravenna IMartorell iStenungsund t 1 1 [united Kingdom IB? Chem IBaglan Bs~ i 1972 1 Finland [Holland [Pekema IDSM !Svartback 1Beek Limburg 1 1 1976 1 France I.Soc Art D'vinyl 1Mazingarbe I 1977 S Spain 1Monsanto Iberia [Tarragona * Laboratory worker in Research Department I YEAR OF 1 1st Exposure [44,54 [46,48,56,41,43 1 157,54,55,53 [51.45,47,46,64 1 146 157 [66,51,62', 63,50 161,61 158 [59,49,65,58,49 150 1 150 1 1 157,63 153 [ 155 [56,57,54,61,55, 161.54,61,62,61 1 1 1 ! 159 1 162.60 I 1 1 [60 1 1 1 i 1 1 P ! P [ r i i i i 1 J 1 | [ 1 j | 1 1 | | [ I 1 I 1 | 1 } I | i 1 1 1 1 1 1 1 I 1 I 1 1 1 I 1 1 1 1 1 1 1 ! 1 1 i i i i i i PJST80061400,3-WPX7 VVV 000003789 TABLE 9 Jr'age USA PVC PRODUCERS - START-UP DATES vs ASL CASES I START-UP | COMPANY NAME 1 LOCATION YEAR 1 1939? |*UCC 1 I S Charleston 1 1940? I *BFG 1 I Louisville I 1 1946? |*UCC t 1 Texas City 1947 1 Goodyear 1948 i Firestone ! Niagara Falls 1 Pottstown 1950 1952 ! Uniroyal 1 Monsanto 1 Dow 1 BFG I Painesville 1 Springfield i Midland I Avon Lake 1953 1954 1956 1 Diamond 1 General Tire 1 Air Products 1 Deer Park 1 Ashtabula ! Pensacola 1 Atlantic Refining 1 Brooklyn ] Borden I Conoco 1 Leominster 1 Hebronville 1 BFG I Great American 1 Niagara 1 Flitchburg 1 Plastics 1 Hooker 1 I Hicksville 1957 I Pantasote 1 Atlantic Tubing ! Passaic 1 Cranston 1 Tenneco 1 Flemington NJ 1958 1 Keysor Century 1960 1 BFG | Saugus, Cal ! Watson, Cal 1 Air Products 1 Calvert City 1 Borden 1962 1 Tenneco 1 Illiooolis I Burlington NJ 1963 I Conoco 1 Aberdeen, Miss 1 Stauffer 1965 1 Conoco i Long Beach, Cal 1 Assonet, Mass 1 Ethyl { Baton Rouge 1966 1 Diamond i Delaware City I General Tire/Pantasl Mt Pleasant W Va 1 BFG 1 Henry, 111 1967 1 Stauffer 1 Allied I Delaware City 1 Painesville, 0 1 Hooker 1 Burlington NJ 1968 ! Firestone 1969 1 BFG 1 Perryville I Pedrickton NJ | Goodyear I Plaquemine 1 Olin ! Assonet, Mass f (Formerly Conoco)1 1971 1 Conoco I Oklahoma City 1972 1 Nat Starch 1973 I Borden 1 Meredosia. Ill 1 Springfield 1974 1975 I Robintech 1 Painesville, 0 1 (Formerly Allied?)! i Atlantic iubing f Cranston RI 1 Shintech I Freeport, Tex i Certain-teed 1 Lake Charles 1 Georgia Pacific | Plaquemine, La 1 Tenneco 1979 1 Firestone 1 Pasadena, Tex 1 Plaauemine My databank has no information on UCC before I ASL CASE 1 YEAR OF I NUMBER 1 1st EXPOSURE 107,13,19,21,24, 144,42,43,46 127,28,29,31 139.41,44.42.46 101,02,03,04,05, 148,55,45,52,44, 106,09,16,17,22, [62,45,50,55,47, 126 147 11 108,10,11,20 146,51,46,55 112. 149 11 i1 1! 1 18 154 11 11 11 1I 11 1i 11 |23 158 11 11 t 1 130 ! ! 159 11 11 11 1! 1 I! 11 1 II i 11 11 t1 I1 11 11 11 11 1! 11 1! 11 11 11 1! i1 1! i1 11 1i !1 1946 or BFG before 1950. | | | 1 | ! | 1 | | 1 1 1 | 1 1 1 1 ! 1 1 | 1 1 1 1 | 1 1 i 1 1 1 1 I 1 ! ! 1 1 1 1 I 1 1 i i 1 ! | ! 1 | i ! 1 NB Some of the plants in this list were closed down, some have changed ownership over the years. 000379 Page 35 TABLE 10 CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES 1 START-UP| COMPANY NAME I LOCATION i ASL CASE | YEAR OF 1 TEAR 1 1 I NUMBER 1 1st EXPOSURE 11 1 11 ! 1943 | Goodrich 1 Shawlnigan 101,02,03,04,05 [44,43,41,45,44, 1(1941?) | 1 106,07,08,09,10 147,46,61,46,53 11 1 11 11 ! 1951 I Monsanto* iI 1 I La Salle 1 1 1 1 1 1 1 11 1 1957 | Goodrich 1 1 Welland 1 1 1 11 1 11 i1 I 1966 I Esso 1 ! Sarnia 1 1 1 1 1I 1I 1I 11 j 1979 | Diamond Shamrock Alb I Fort Saskatchewan 1 1 1 1 11 1 11 * Terminated 1975 VVV 000003791 Page 36 TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES I START-UP | COUNTRY NAME YEAR 1 1941 1 Russia 1950 1Yugoslavia l COMPANY NAME 1 (State Comps IJugo Vinil 1951 |Czechoslovakia 1 State Comps 1955 (East Germany (State Comps 1 1956 IRumania 1 (State Comps 1957 | Poland 1 State Comps |Rumania (State Comps 1 1958 1Rumania 1 (State Comps 1959 I Hungary 1 State Comps 1961 1Rumania (State Comps 1963 JYugoslavia (Ohis 1965 [Bulgaria (State Comps 1967 (Poland 1969 I Russia 1 State Comps (State Comps 1970 1 Rumania 1 Russia 1 State Comps (State Comps 1972 I Yugoslavia 1Vinilplastika 1975 [Czechoslovakia (State Comps 1976 1977 I Russia 1Yugoslavia iRumania 1 State Comps 1 Hip 1 State Comps | LOCATION 1 1 Vladimir et al (Split |Novaky IBitterfeldt 1Schkopau 1 Icechim lOsweicim (Dwory) (Tirnaveni (Turda IRisnov (Berente Borsod IBorzesti 1Skooie 1 Varna (Tamow 1Dieriinsk IRimnicu Vilcea 1 Volgograd 1 Zadar 1Neratovice IKalush Area 1Pancevo IRimnicu Vilcea PJST80061400,6-WPX7 J0cM 0 1 1 ASL CASE I NUMBER ( (01,02.03,04 1 1 1 1 ( 1 1 ( 1 1 I 1 ! 1 1 1 1 1 1 1 | YEAR OF 1 1st Exposure 1 (53,50,54,48 157,51 t 1 1 1 1 ! 1 ( 1 1 1 1 1 1 1 1 1 1 VVV 000003792 Page 37 TABLE 12 JAPANESE PVC PRODUCERS START-UP DATES vs ASL CASES |START-UP I COMPANY NAME YEAR 1950 1 1 Chisso Corp Kanegafuchi Rag Tekkosha 1951 1 Mitsui Toatsu 1952 Mitsubishi Mon 1 Sumitomo Kag 1951 Denki Kagaku Nippon Zeon Toa Gosei 1955 Ryo--Nichi 1956 Nippon Zeon Nisshin Kagaku 1957 Kureha Kasei Shinetsu Kag 1960 Denki Kagaku Kanegafuchi Kag 1964 Chisso Com 1966 Tokuvama Seksui 1967 San Arrow Kagak Sumitomo Kag 1968 Ryo-Nichi Shinetsu Kag 1970 Chisso Corp Denki Kagaku 1 Kanegafuchi Kag Kawasaki Yukl Mitsui Toatsu 1 Nissan Kagaku 1 Shinetsu Kag 1971 Tekkosha 1973 1974 1 Asahi Glass 1 Toyo Soda 1975 ! 1 Central Kagaku ! Toyo Soda 1977 1 Unknown PJST80061400 > 7-WPX7/2 l LOCATION 1 | Minamata | Osaka I Sakata 1 Nagoya l Yokkaichi t Klkumoto I Shlbukawa I Kambara 1 Tckushima 1 Uozu | Takoaka 1 Takeo i Nishiki I Naoetsu | Ohml 1 Takasago I Chiba 1 Tokuvama | Tokuyama 1 Chiba I Mizushima 1 Tokuvama 1 Mizushima I Goi (Chiba) | Kashima | Kawasaki I Sakai 1 Chiba ! Kashima | Yokkaichi 1 Hayatsuki | Sakata | Yokkaishi | Kawasaki | Yokkaichi 1 Kashima I ASL CASE 1 NUMBER 1 I 1 1 01. 02 1 1 1 1 1 1 1 1 1 1 1 1 1 1 t 1 1 1 1 1 1 1 1 I i I 1 1 1 1 1 1 I YEAR OF ! 1st EXPOSURE 1 1 1 53, 58 1 i 1 1 1 1 1 ! 1 1 1 1 1 1 l 1 1 1 1 1 1 1 1 1 I 1 1 i 1 1 1 1 WV 000003793 Page 38 TABLE 13 SOUTH & CENTRAL AMERICAN PVC PRODUCERS | START-UP I 1 YEAR 1 1953 | 1954 1 1955 1 1956 1 1960 1 1961 1 1965 1 1966 1 1967 1 1968 1 1970 1 1971 1 1975 1 1976 ! 1977 | 1978 1 1 1979 COMPANY NAME Monsanto Mexica Policvd Geon Do Brazil Elchlor Electrochlor Viplastic Indupa SOC Paramanga PET Columbiana Carburo De Col Plasticos Omega Primex Policasa Petro Dow Polimeros Mex Rico Chemicals Petroplas Indust Resistoc Huls Brasil Polychem Policyd PET Camacari I LOCATION 1 1 1 Lecheria (Mexico) t Mexico City (Mexico) 1 1 1 Sao Paulo (Brazil) | Sao Caetano (Brazil) 1 1 (Capltan Bermudez(Argentina) 1 I Mendoz (Argentina) 1 | Cinco Saltos (Argentina) 1 I Paramonga (Peru) 1 Cartagena (Colombia) 1 Medellin (Colombia) 1 ! 1 1 Mexico 1 Puebla (Mexico) 1 1 I Managua (Nicaragua) I Conception (Chile) | St Martin Puebla (Mexico) 1 1 1 I Guyanilla (Puerto Rico) | EL Tablazo (Venezuela) I Tlazcala (Mexico) 1 1 1 I Cubato (Brazil) I El Salvador 1 Coatzacoalcos (Mexico) 1 1 ! 1 Camacari Bahia (Brazil) 1 ASL CASE NUMBER 1 YEAR OF 1 1st EXPOSURE 1 1 1 1 1 1 1 1 11 ! 1 l 1 1 t 1 ! I 1 1 ! vvv 000003794 IMPERIAL CHEMICAL INDUSTRIES fLC PETROCHEMICALS ANn PLASTICS DIVISION LIVER Angloaarcoaa Cnaea - (Review Kate: I Jan 1984) Germany Sheet 2 Page 10 10 n COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OP MIRTH COMPANY FACTORY FIRST VC EXPOSURE RATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIACNOSIS TEARS OF EXPOSURE DATE OF DEATH IIISTOJ-OCtCAL CONFIRMATION ESTIMATED EXPOSURE I OCCUPATION LEVEL I OTHER CAREER HICIIMIJHTS OTHER COMMENTS GERMANY US (NIOSH glvaa aa Caae 06) 00.00,16 Hoechat Frankfurt 02.04.60 10.12.73 38 03 16.12.74 Yea (NIOSII) 06 (NIOSH givei aa Caae 03) 07 00.00.32 Lontn Ualdthut 16.12.62 00.00.73 4) 00.00.26 Rurghauaen 13.04.34 12.11.73 49 12 09.01.73 Tan 21 21 13.11.73 ( NIOSII aya 12) 08 UO.UO.l7 Dynaelt Troladorf 19.07.34 06.04.73 38 20 25.12.73 1 I | BG Clieale laaya | 'chtalitrjr |1aboratorIon I In the ITecItnollogfca) IReaearch |Oeprtant' I(NIOSH aaya laaalatant Ifactory (chenlat laklch nay be |wrong (translation) I I IfVC - HnnuIfacture ISlilft Uadet I J___________ I |PVC Manu| factora end lall work Itnct autoIcleanlng 112 yra 1(1934-66) (Foreaan Tech |Dev 6 ;ra 10 967-19 7 3) 1 1 Polyworker I I 1 I Gonf I racd Hupurtt-d un.let iu>i-|iulyaorlaxtIon worker* In NIOSII llat ol 11.3.77 and 1.78. I don* t think title la a correct clasalflent Ion lip NIOSH. Hie an ay have lieen Involved In VCM pulyaerlialJun I n pi lot l l Bill or in aain plant. VVV 0 0 0 0 0 3 8 0 7 41 COUNTRY AND REFERENCE NO NAHE OR INITIALS DATE OP BIRTH IMPERIAL CHEMICAL INDUSTRIES PLC PETROCHEMICALS ANU PLASTICS 1) VISION LIVER Angioaarcona Coaea - (Review Da e; I Jan !94) Ceiajny Sheet I 10 12 FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS TEAKS OP EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HICIII.ICIITS Page 9 OTHER COMMENTS 01 00.00.10 Dynaalt Troliloif 01.I0.S6 19.09.6fl IB 12 2S.OI.69 Tea (NlOSIl) Polyworker 02 00.00.11 Dynaalt Troiadorf I4.IO.S7 25.09.70 39 14.12.71 Tea (NlOSIl) Polyworker I 01 00.00.50 Dynaalt Rhetnfel- 09.06.52 00.03.73 43 21 16 10.10.7) Yea (NlOSIl) Filling den pesticide I |RL'|x>rtud under |non |iulyaer- aeroaol cans Itaattun with VC |worker lit INIOSH Hat of 131.3.77. Illila of ruune l(a ettlctly (correct. 1 However 1 IwonJcr I whether tlila Inin had high |eK|miure to |VCH In hl (can filling (operationT i I 04 00.00.30 Burg- 16.04.57 26.11.74 44 17 17 25.11.74 Tea (NIOSH) 200-500 ppai polyvorkcr 6 1958 waa (ClInical lauaen but high temporary ittoc t chic r (lelalla In during l yr autocleauec (or 1 yr Ipapcr by autocleaner |CokeI el al (Virchows Arch I A Pnili 1976 | J72 |> 195-201 I I 0900000 HIHS IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION LIVER Aitg loaarcoaa Caaea - (Review date: I Jan 1984) Prance SHeet K Pago A 2 11 4 t 1 6 | 4 1 1 COUNTRt AND NAME OR DATE OP 1 1 FIRST PC REFERENCE INITIALS BIRTH 1 COMPANY 1 PACTORY EXPOSURE NO 1 t _L X X X X 7| 8 9 10 1 12 11 1 1* 1 1 11 1 DATE OP | ACE AT TEARS OP TeARS OF OATE OF NISTOLOCICAL 1 ESTIMATED 1 1 I DIAGNOSIS | MAGNUS!s EXPOSURE TO EXPOSURE OKATII CONFIRMATION EXPOSURE | OCCUPATION | 1 DIAGNOSIS LEVEL 1 | LX X XX XJ 1 15 1 | OTHER CAREER HIGHLIGHTS 1 1 1 1 _!_ 16 OTHER COMMENTS I| Prance IS 16 CIM I 1.07.22 Chine | St Pone | 07.07.55 128.09.82 Chiale | 1 1 (foraerly | 1 RP) | I 1 11 1 11 1 1J J China Chiale (faracrlr RP) Sc Fona 27.10.* 05.01.81 1 ( 1 I J *5 27 -1-- 61 *1 1 27 (Alive 1 Tee 1 11 1 11 1 1l 1 11 1 11 ! _! _L... 18 Alive Tea |High-20 yr (Autoclave | |Moderate leleaner I 17 yr# 11955-1962 7 1 (autoclave | 1 (operator | 1 11962-1982 ( 1 JL Hlgh-33 yralPolyaerlaat- HnJcrtt*- |lon Fruccii Low - 1 yra|Han I (Maintenance |Worker |J C Coittaauot (Letter of |5 10 1981 1 I 1 J Ret I red Jan 1979. .1 C Gmtaweot Letter of S 111 1981 I t i i i i 17 | HAH 122 02.23 | Chloe |St Fona 1 17.06.48 ( 03.04.81 60 1 t 1 Chiale ( 11 1 1 ( (Foraerly | 11 1 1 1 RP) 1 11 1 11 1 11 Health A Safety Agent i ii i 34 1 28 101 04.83 | Tea IHlgh - lutoclava (Ollier vectors (Retired I 11 123 yea Cleaner |of St Fona (01.01.79 1 t1 1 1948-1971 (Factory |97l- (J C Contaa 1 11 1 11978 I letter of 1 11 1 |5 10 1983 VVV Q 00003905 -n COUKTKT AND REFERENCE NO NAME OR INITIALS DATE OP BIRTH IMPERIAL CHEMICAL INDUSTRIES PLC PETROCHEMICALS AND PLASTICS DIVISION IVKR Angioaarcoae Cane* - (Review Date: Jan 1984) Prance SlircC 1 Pa8e 1 I) IS PIRST VC EXPOSURE DATE OF DIACHOSIS ACE AT DIAGNOSIS TEAKS OF EXPOSURE TO DIAGNOSIS TEARS OF EXPO SURF- DATE OF DEATH MISTOIOCICAL CONFIRMATION ESTIMATED EXPOSURE | OCCUPATION LEVEL ) OTHER CAREER IIICIII.ICIITS OTHER COMMENTS 10 12 IT 24.0S.I9 15.02.12 RP 00.12.36 10.01.28 00.01.41 12.08.78 66 17 10.01.7ft 11.11.78 6.08.14 pare Brlgnoud 09.02.49 00.05.79 65 19.01.11 Sol vay 23.64.63 26.06.79 "IT 30 TT 27 21.06.79 tr TOOT 05-04-24 Chloe CliUlr (Formerly Rl1) 1941 00.07,ft| 57 38 16 I .I High (Autoclave |cleaner IU yta In aechanleal engineering ifnluHt r y 1946-1956 Died at piilnmiiiry eiabolIaa 5 dnyw after mirge r y High 11941-1946 Ipolptrjlaation Igeneral | purpose I worker 11946-1972 (VCM (apntheele |(MCI 6 (Acetylene) IForeaan | (agent |da maltrlae) (7T7T (retired I High |Mnnnotr (production land polyae (IaatIon |operator |Autocleancr 17 Fra, |Anto(operator |9 pea, | Copolynen (4 pra I I I Very High 11941-1976 1941-1975 1 Al I ly|.ea of and I Jobs on Ini el mi11 | m.mol. nm vnl ly |4 .............. 1975-19/9 lln VCM Ini y 2 ym aw cycl aechanlc. 10 yra au enaaelIer In aanltarp ware aaanuf ac t me 1975-1979 wuik Cigarette tenU'i nnt 11 19/4. Ill nil of 1977 due to Oo eapli.igeal Vjrlrvn. Surgical Intervention 25.llS.79 (right Ik- I'rttoiiowy) VVV 0 0 0 0 0 3 8 0 4 IHPERIAI. CHEMICAL INDUSTRIES PI.C PETROCHEMICALS AND PLASTICS hlVISlON LIVER Angloaarcoma Cixia - (Review hates 1 Jan 1904) Prance Sheet 2 Page 6 COUNTRY AN0 REFERENCE NO NAME OR INITIAL5 DATE OF BIRTH FRANCE 06 Pa 14.04.14 FCUK 07 CIR 26.04.27 06 01.04.34 Solvay 09 06.10.14 FIRST VC EXPOSURE Brignoud 01.03.58 DATE OF DIAGNOSIS 12.OB.76 ACE AT DIAGNOSIS 42 YEARS OF EXPOSURE TO DIACNOSIS IB 10 12 TEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION 13 11.09.76 (NIOSH aaya 12.09.76) Yea I) I ESTIMATED | EXPOSURE | OCCUPATION LEVEL | Moderate I I I ((1958-1960) |2 yrm (filtration 110-11 yra | polymarker land works |lab7 I I OTHER CAREER HIGHLIGHTS 16 OTIIKR COMMENTS 0.1 a won Dud AOL prior to AS. Aim. de Hal. Prof. Jiily >77 p 645 4 6. AOL aai found in I97| five yra before ASI. St Auban 01.07.50 After death NIOSH aaya 00.07.76 Tavsua 23.05.57 03.12.75 42 26 19 10.01.46 26.04.76 63 2B 02.07.76 Yea High (Plant fore 1972-6 adal Died of (H10SH no man In aectlon In aepttravels Hit) (polymer- St Auban Seall liver (laatlon I J__________ I lealon found after autopsy 19 30.01.77 Moderate |6 yra packer |4 autoclave (clnr Had been tunnel worker previously 114 yra (autoclave 26 25.12.77 (worker I__________ I Very High |Polymer- 10 yra In Operated 4.76 1948-1966 (laatlon aulpburlc for removal of Leaner (operator. acid factory, tumour from Exposure (sutoclcsner, atorekeepor 4 liver ami 1966-1976 |autoclave general died after (aalntenance aervllcs ccoml ( surgical opvcat Ion f or blllo bronchial fistula Paper by Di Rely ft al to Arclilvcu de Mol .nil's Pi olvmb Iona Is Vul Ml No 6 r>7*J page* 7 4 I- 1. VVV 000003803 IMPERIAL CHEMICAL INDUSTRIES PLC PETROCHEMICALS AND RUSTICS DIVISION LIVER Angloaarcoias Caaea - (Review Date; 1 Jan 1904) France Sheet | Page 3 1 1 1 t tCOUNTRY AND | 3 1 | 3 1 J 1 1 NAME OR | DATE OF REFERENCE | INITIALS I BIRTH NO 1 PRANCE ( 1 1 1 t 1 1 1 4 1 | 5 1 6 11 7 1 | A 11 9 _J1 1 1 11. 1L 1 1 1 1 FIRST VC | DATE OF | ACE AT | YEARS OF 1COMPANY | FACTORY EXPOSURE | DIAGNOSIS I DIAGNOSIS | EXPOSURE TO 11 1 1 | DIAGNOSIS 111 1 111 1 111 10 1 1 1 II i YEARS OF I DATE OF EXPOSURE I 1 1 1 1 DEATH 12 HISTOLOGICAL CONFIRMATION 11 11 14 11 11 11 1ESTIMATED | EXPOSURE LEVEL | OCCUPATION | 1| 1> 11 11 >5 OTHER CAREER HIGHLIGHTS 11 1 1 | | 1 1 1 1 16 OTHER COHHENTS | | 1 I | | |1 | 1 Ol |H i i i t j 02 i | SIH 1 1 1 1 1 1 0) 11 |NAV 1 t 1 I1 04 11 |MOR I1 1 1 1 1 J 05 I |t 1 1 1 1 1 1 1 1 1 1 1 1 1 in.04.24 1 RP i i i i j i103.06.1 1 1 1 1 1 1 1 11 |06.01.20 1 1 PCUK RP I 1 1 11127.01.27 1 1 1 1 1 PCUK ( 11129.01.38 PCUK i1 1 1 1 1 1 1 I 1 1 1 1 |Routs- 00.01.46 | 18.02.67 | 43 I | Ilian 1 1 1i )\i 1 1i 1 11 | Br IgnouJ X 06.07.39 t1 1 | 11 15.01.75 1 1 1 1 1 61 i j i t 1 1 I11 1 11 1 \1 i 1>1 1 1 l1 11 | St Fon# J1 11 00.00.46 | 15.01.75 | 55 1 1 1 1 111 1 111 1 1 11 1 111 1 1 11 11 IBrlgnoud 19.10.49 \1 | 16.01.76 11 | 49 1 1 1 1 1 11 1 I11 1 1 1 1 11 1 1 11 1 111 11 |Brlgnoud 18.01.65 11 | 13.05.76 1 l | 38 > I 1 1 I1 1 111 1 1 11 11 11 11 1 1 1 11 1 11 1 1 1 I1 1 1 1 1 1 1t 1 11 1 \11 111 21 >6 29 26 M \ 19 119.02.67 1 Ye. 1| High )Autoclave |Nef. Kevier et| i i i Ii 1 i 12 i124.01.75 Yea High (worker nnJ Icleaner >19 yra 1 I 1|2 yra on 1 1 1 1 1 1 111 alIan 1|al Arch. Hut, ) | Prof. Ml n* | |1 Nov 75 | |p 171-177 11 11 | R f . | 1 1 1 (NIOSII no 1 comment) | cmows r >0| yra on (origin 1 1|G Bonne ton et | |dl "Ntuivel e | 1 1 1 1 1 11Ipolyme raatIon 1 1 1 1 1 1 ||>rwc (aedicule- |5 Nov 1977 |p 715 l | | | 1 11 1 | 1 11 1 29 >29.06.75 1 1 1 1 Yea High IPolyworker >10 yra aa |*uCoclava Icleanar (Compounding |VCM productIon|Ref. Rely et >16 yra |nl Arch. Hal. 1 37(Italian POW IProf. n* | ShoplicrJ, |6 June 71 (Sawyer. Kaaon |p 551-555 | | | | | 1 >5 yra 1 1 1 1 1 26 1104.01.76 T Yea High I | Monoear >1 1 11 1 11 1 1 1(production 1 1 1 (worker 1 1 1 1 18 vre > 1 1 1 IFVC 1 t 1 1 1|fIltratIon 1 1 1 8M yra 1 1 1 1 11 1>13.05.76 > ) 1 1 1 1 1 1 1 Yea High 1 1 |Polyworker III yra 1 1 1 1 1 1 1 1 l1 1 11 1 |t)Thoracotomy | Re I. P Comlcrel 191h Feb 1976 1let al " Scm.i ne | Icuatul | ilev lioHpIt.tiX | 1jauRlnaarenna |0 Seplcnhre | 2 ) Sr I m 1 g ra|>li y t 1976 | 51A . (Previously tto.ll 3| )IUcmi>i rlingi: llioile | 1 from A SI. I'ORlRl.t | !! ]>< <' c 1 nuty 1|>ioi; ou.ir ii.ioi ' | 1| A H`l | 1III Mi l.uusk <l| 1l > lot "l..i Nnnvel lr 1 1 1 ..........Mrillc.llr 1 1 7l | t It lot y ft/'t | 1 11 VVV 0 0 0 0 0 3 8 0 2 IMPERIAL CHEMICAL INDUSTRIES PLC PETROCHEMICALS AND PLASTICS DIVISION I.IVE* AnglnaarcuBS Casea - (Review Date: 1 Jan 1984) P*g! 4 11 1 * lODIMiaV AND | REFERENCE | NO ICZECMOSLO1 VAR IA 1 Ol 1 i 02 2 |3 1 1 NAME OR I INITIALS I DATE OP R1RTH 1 1 1 1 < 1 128.06.28 1 1 1 1 1 1 106.01.27 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 4 COWANY State Co State Co 15 1 1 1 FACTORY 1 1 1 1 1 1 1 Novaky 1 1 1 1 | 1 1 Novaky 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 6 FIRST VC EXPOSURE 01.07.57 01.11.30 7| 6 1 1 DATE OF | AGE AT DIAGNOSIS | DIAGNOSIS 1 24.12.71 I 1 1 1 1 | 43 1 1 1 1 27.11.64 * 1 37 1 1 1 1 1 1 1 1 1 1 1 1 1 t 1 1 9 YEARS OF EXPOSURE TO DIAGNOSIS 16 14 10 1 *t 1 1 TEARS OF f DATE OF EXPOSURE | DEATH 1 1 1 1 1 1 16 124.12.71 1 1 1 1 1 1 13 126.11.64 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 12 IIISTTMXtCICAL CONFIRMATION Tee Yea 13 t 14 1 13 i i ESTIMATED i 1 1 i OTHER EXPOSURE I OCCUPATION I CAREER LEVEL 1 | HIGHLIGHTS 11 11 1 |lARC letter 1 lot 1-4-02 (Autoclave Ijflvfog lll-tlllt (Cleaner (frua Prof 1 |A David of 1 ICentre In.) 1 Illyglenu anj 1 |Occ diamines. 11 1 (Autoclave 1 |IARC letter of (Cleaner 11-4-02 gave 1 | soaewhat 1 loitered Jates 1 |for elite case. 1 |I have 1 laccepteJ the 1 Icluiiigcu since 1 |the date* ciiae 1 Ifroa Prof ( |A David of the 1 ICentre of 1 |industrial 1 (Hygiene and 1 | Occup.it Jonal 1 | Dlsunsca. My 1 (dote* ton 1 lot1 ({Inal 1 y 1 Ifroa HIOSH. 16 | OTHER COMMENTS 1 | VVV 0 0 0 0 0 3 8 0 1 IMPERIAL CHEMICAL INDUSTRIES PLC PETHOCIIFMICALS AND PLASTICS DIVISION LIVER Angluaarcoaia Casee - (Review Date; I Jan 1904) PAT - MONTH - YEAR * All dates uae UK ayatea Slice! 2 CanoJa- ** Data published In Journal of Occ Hed 1978 pages 330-340 *** Many of dates altered to fit NlOSIt 31/3/77 llat Page 3 1 COUNTRY AND REFERENCE NO CANADA 2| 1 1 NAME OR | INITIALS | 1 1 1 1 3A PATE OP tIRTH i COMPANY _L I I5 J ) 1 1 FACTORY 1 | 1 61 _L 8 J_ first vc DATE OP ACE AT 1 1 1 | EXPOSURE DIAGNOSIS DIAGNOSIS | 1 1 1 1 9 YEARS OK EXPOSURE TO DIAGNOSIS 10 1 1 YEARS OP | EXPOSURE j 1 1 1 DATE OF DEATH 12 HISTOLOGICAL CONFIRMATION 13 1 >4 1 l 11 ESTIMATED 1 | EXPOSURE | OCCUPATION | LEVEL 1 | 11 11 11 15 OTHER CAREER HIGHLIGHTS 10 1 | I 6.05.15 l 1 11 1953 1976 1 61 I 23 14 100.04.77 Yea 1 1 11 11 1 1 1 | 1I hReactor |cleaner 1 )FmMacop. lulntciidiice, |packaging 16 OTHER COMMENTS Its - Ninoker I < ooetooooo IMPERIAL CHEMICAL INUUSTKIKS PLC PETROCHEMICALS AMP PLASTICS DIVISION LIVER Angloaarcoaa Caeca - (Review Date: I Jan I9B4) * All dace* uac (DC ayateu r^nwit PAT - MONTH - TEAR Sheet 1 11 Data publlahed In Journal of Acc Had 1978 pagea 338-340 *** Many of datea altered Co fit MIOSII 11/1/77 I lac Pa*c 2 1 1i 11 2 1 3| 1 11 I ICMUftitY AND 1 REFERENCE 1 1 NO 1 1 NAME OR I INITIALS ( I i DATE OP I BIRTH | 1 1 1 (CANADA 1 1 1 11 11 1( 1 1 01 1 1 11 113.12.13 1 1 11 ! | 11 l1 1 1 02 1 1 1 | 11 1 03 1 106.03.14 t 1 11 1 J1 11 (126.08.19 ,1 1 1 1 1 1 _L l 04 l 11 1 1 1s 103.04.19 1 1 I 11 l1 1 1 i 1 [it \ ; i 03 I l l i i r1 i 06 i ii ii i\ ii i 07 i 11 11 107 .03.11 1 11 11 1l 11 1(13.12.19 11 11 11 11 1(09.11.19 i i 11 i i 11 11 ii i 08 i ii 11 113.03.20 1 11 i i 1t ii i 09 i 11 119.07.21 1 i i 11 i 11 i 11 1 4 |3 COMPART i l1 i | FACTORY 11 1 1 SHAWIHtCAM I 1 1 11 11 11 1 1 1 1 11 11 11 1 I 1 11 11 11 s1 1 1 11 11 11 11 1\ 11 11 11 1 11 1 i 1i 1i 1i 11 1i 1i 1i 1i 1I 1i 1i 1i 1I 1i 1t 1i ti 1i 6 FIRST VC EXPOSURE 1944 1943 1941 1943 1944 1947 1946 1961 1946 ta DATE OF 1 AGE AT DIAGNOSIS DIAGNOSIS 1933 1937 1962 1967 41 43 42 48 1968 57 1971 51 1972 53 l 1973 53 1974 51 9 TEARS OF EXPOSURE TO DIAGNOSIS 11 1 I 1 14 1 1 ! I 21 l 1 22 1 1 1 1 24 1 1 1 24 26 l 12 28 1 10 1 11 1 1 YEARS OF I DATE OF EXPOSURE | DEATH 1 1 1 1 1 ,, 102.09.35 1 1 1 14 (21.12.57 1 1I J1 20 123.03.62 f( 1 1 22 121.01.68 1 1 1 1| 1 05 (05.07.68 1 1 1I 2) (10.04.71 1 1 1 I 25 (24.12.72 1 1 1 1 05 112.06.73 1 1 1 26 (04.09.74 1 1 12 IIISTOIAGICAL CONFIRMATION Tea Tea Yea Tea Tea Yea Tea Yea Yea i* Paper bjr Dr F DEI.ONHE in Anoalca <i' A/jhIcut 1 e patholog 1 i|ue Parle, 97B Vot 23 No 2 |.j>l05-ll 4 claims (.Me cane had both e 1 pa > a .inJ ASI. el 1 13 t 14 1 1 1 15 1 16 I 1 ESTIMATED 1 EXPOSURE | OCCUPATION LEVEL 1 1 1 1 |1 Reactor Iclaaner 11 1 ( OTHER 1 | OTHER | CAREER | COMMENTS | IIIGMIICMTS 1 11 11 11 1 10|>eraLor 1 | Smoker |polynerlaatlon| 11 11 I Maintenance '(Operator 1 1 I Worked laUllvrlglit, |plpefltter J1 (Operator, |loreain 1 1 1 1 1 1 1 1 lovuitlae ISaoker J( (Worked (overtlae |Non-amoker 1 1 I Reactor Icleaner 1 1 (Operator, |lufvaan, 1 1 (Worked (overtlae 1 1 1 1 1 Reactor Icleaner 1 1 i I Reactor (cleaner 1 J 1 I Reactor Icleaner 1 1 1 (Reactor Icleaner (water cooling (Sauket (unit ( 1 1 1 t(Water cooling |Worked |unl (overtlae ( |Smoker 11 1I (Maintenance, (Worked * lulllwrlght 1 1 1 IHacMne ahop (operator and (overtlae (Soaker 11 (Worked (overtlae (paly unit | Smoker 11 |Maintenance 1 I In plant (a.itliloe shop 123 yial Sa< ke-r 1 |Furnace op. | pipcfIt tec |uai >( 1'nnnre 1 1 1 1 1 1 t 1 |Worked (overtIme IS.iL.kel 1 tain........ y VVV 0 0 0 0 0 3 7 9 9 IMPERIAL CHEMICAL INDUSTRIES PLC Page I PETROCHEMICALS AND PLASTICS DIVISION A LIVER Anglaaarcoaa Cnees - (Review Date: I January 1984) 11 1 2 11 | 1I 1 * f 11 I1 }COUNTRY AND NAME OR t DATE OF | | REFERENCE INITIALS | BIRTH | I NO 11 1BELGIUM 11 11 11 A COMPANY 11 i i i l1 15| 6 1 7| 81 9 10 1 II 11 1 1 1 1 1) 1 1 1 | 1 1 FIRST VC | DATE OF | ACE AT | YEARS OF YEARS OF | HATE OF 1 FACTORY | EXPOSURE | DIAGNOSIS | DIAGNOSIS | EXPOSURE TO EXPOSURE I DEATH 11 1 1 1 DIAGNOSIS 1 \ 1 1 1 I1 1 1 1 (1 1 1 1 1 1 oi 1 1 1 1 i 1 \ 1 1 1 1 1 1 1 1 1 1 1 1 i 1 1 1 1 I 1 1 1 1 1 1 | i.oi.ii i Solvajr 1i 1i 1i 1i 1i 1i 1I 1I 1I 1i 1i 1I 1l I 1l 1i 1I 1i 1i 1I 1I 1l 1i 1t 1I 1I 1I 1I 1I 1I 1I 1I 1 Jeteppe | 00.07.5ft | 00.05.76 1i i 1i i 1i > 1i i 1i ii 1i i 1i i 1i t i \ ii \i ii ii ii ii ii ii ii 1i i ii 1i i ii 1i i ii 1i i ii 1i i ii ii ii | i \ i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i 65 | i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i i 18 17 (29.06.76 1 1 1 1 1 1 1 l 1 11 1 11 1 11 1 11 1 1 1 11 1 1 1 1 t 1 1 1 1 1 1 1 ---------------------- r 1 12 | 11 1 1* 1 15 11 || | HISTOLOGICAL | ESTIMATED | | OTHER CONFIRMATION | EXPOSURE 1 OCCUPATION | CAREER 1 LEVEL t l hichi.ichts 11 1 11 1 11 1 1 Yea | 111 B>> IA utocleaner |Dr 111.r In a 1 |l 4 yre | found ry 1950-1968 | 1(2 yra) 1 exposed tolPotyworker It'arracr 200 pp n 1(15 yra) 1 for 0 hra | (Work In Klava 1 per day 1 |inj. 4 cheat- 1 and | |csl Imlnutry 1 certainly | \ 1 under 1 1 1 300 ppa | 1 In 6 to 1 93 | 1 1 autoclaveal 1 "|96i-i9#2 | 1 exposed to| 1 1 1 1 1 1 1 30-200 pp*| 1 1 8 hra per | 1 day In | 1 25* 3 | 1 1 1 1 autoclaveal 1 14J2-I4H | 1 I 1 exposed cot 1 1 30-200 pp| 1 In auto- | 1 clave rooal \ 1 1 1 1974-100 | 1 1 PP* 1 1 1 1973- 30 | 1 1 PI* 1 RETIRED 1 | 1 1 1 1 Fb 19751 1 11 1 1 lb ) | OTHER | COMMENTS 1 1 1 1 1 JNepal1c tents 11 n Oct 1974 | were noriaa 1. | Ret Ireil |Feb 1975 | lloepi tel 1 wed (Key 1976 1 | Coaplete ICIinlcnl and (career <let alls) (are Riven In t | I paper by liniblet ei ol |ln Arch. fUsIg |Hod. Sue., 1 IlyK MJ. ITrav. Hod. 1 Leg. 119/7 page* 1601-622 1 1 I 1 1 1 1 1 I 1 1 1 S6Z.ODOO A M 000003797 IMPERIAL' CHEMICAL INDUSTRIES PLC PETROCHEMICALS AND PLASTICS DIVISION LIVER ANGIOSARCOMA CASES (REVIEW DATE - 1 JANUARY 1984) Table Sequence Belgium Canada Czechoslovakia 1 2-3 4 ASL Case Numbers by year of Death (Table 6) ASL Case Numbers by year of first exposure (Table 7) France Germany Italy 5-8 9-13 14 Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Cases (Table 9) Japan Norway Sweden 15 Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10) 16 East European PVC Producers - Start-up Dates vs ASL Cases 17 (Table 11) UK USA Yugoslavia IB-20 21-26 27 Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South & Central American PVC Producers - Start-Up Dates (Table 13) Incidence of Cases pa (Table o 28 Distribution of Cases by Country (Table 2) 29 Pattern of Cases by Factory (Table 3) c < < Latency Periods (Table 4A) 30 31 Distribution of Latency Periods (Table 4B-4II) 32-8 Annual Geographical Incidence ( Tn b I e 5) 39 40 41 42 43 45 46 47 48 PREFACE ACKNOWLEDGEMENTS, SIGNIFICANT CHANGES AND COMMENTS 1) Since John Stafford's retirement from ICI, I am pleased to say that he has been elected an Honorary Fellow of the Faculty of Occupational Medicine at the Royal College of Physicians, London. 2) I would like to thank Dr Paglialunga for all his patience and hard work in helping me to acquire the necessary facts which enabled me to place the recent Pansac ASL in the Register. 3) I would like to thank Dr Laundrie, General Tire and Rubber Company, Akron, Ohio, and Dr Dacey, Robert A Taft Laboratories, Cincinnati, for informing me of recent ASL cases. 4) I am grateful to Dr Contassot for sending me information about three new ASL cases which have occurred at the St Fons' Factory in Lyons, and also for the full account which he gave. 3) I should be very grateful if I could be kept up to date with the five ASL cases which I have placed in the Register, who are all still alive at this present time. 6) I would like to express my appreciation for all the help I have been given in carrying on the work of John Stafford by everybody who has sent me their helpful comments and communications. 7) On taking over the Register, 1 discussed with Dr John Stafford his present format. We both felt this would be the appropriate time to consider any worthwhile comments about its presentation, and also suggestions for any way it could be improved, in order to benefit future analysis. B BENNETT 17 Jan 84 9 W 0 0 0 0 0 AAA i a o o o > Utar Anutawrca-- Cdti Circulation Dr A Boss AdMi, Air Products Hr P M Anderson, Wilton Dr V C Buroeo Jr, Monsanto USA l)r John Dorr, Air Products Dr Peter Baxter, UttS Dr Brian Bennett, Hilihouse (20 copies - 1CIA, AUCI, Duperial) Dr Piei-le Dertstci, Milan University Dr Beache, Dynsait Nobel, Troiodorf Dr F W Beat, Everberg Dr C Bishop, EMA9 Dr E BoogM, AEC1 Ltd, Plastics Dlv'n, PO Box 1122, Johannesburg 2000, South Africa Dr David Bryson, AO Di vision Hr David Burgeon, ]CI Americas Dr David Byrsn, Kemanord Dr J T Carter, BP Hr C Celia, Kontepoliaeri Mr N Chance, VCM Technical Manager, Homl Hr P 0 Claus, APHE Mr Harold Clayton, Norsk Hydro Dr Conlassot, Chloe Chlsie, St Fons Dr l V Dacey - NIOSII, Clncinatti Mr J 0 Davies, Everberg Sir Nichurd Doll, Wnrden, Green College, Oxford Mr Q Dupont, APME Mr H Ewnlnger, VKE Ur U Enint, Berufsgenossenseheft der chealschen Industrie, Numbers Dr Henry Fslk, CDC Atlsnia Dr D M Ferguson, ICJ Amerlcae Dr H P Friedel, Barufagenoeaensehsft der chesiechen Industrie, Heidelberg Prof L Oolberg, Duke Univereity Medical Center, Box ?91*> Durham, North Caroline 27710, USA Dr B E Qoastonyi Jr, Tenneco Chemicals, Saddle Brook (NJ) Dr Wulter D Barrie, Uniroyal Inc Dr Donald W Killeen, Diamond Shamrock Dr Hubert K tllnderar, DF Goodrich (Cleveland) Mr J Hodgson, DUS Dr k A Hogg - lapsrial Oil Ltd, Csnsds Dr J K Howard, Wellington Clinical School of Medicine, University of Otsgo, Wellington Hospital, Wellington, Mew Zealand Dr N F Huaphry, IC1 Australia Operations Pty Ltd, PO Box *t)ll Melbourne, Victoria JOOl, Australia Hr d Jauvert, Chloe Chlsie, Peris Mr II M Jervis, Mlllbank Dr M N Johnson, BF Goodrich Dr Bruce Xarrh - Dupont Dr B A Krueger, BF Goodrich Dr J P Loloine, Solvsy IV .lm. H'l Hr J Lnwrcnce, SPJ Dr F I Lee, Victoria Doepital, Blackpool l`rof W K Laibach <- University of Bonn Dr D A Lcvison - St Bartholomew's Hospital, London Ur P Lewis, CIA Hr Lolivicr, Solvsy Prof H N H MucSveen - Western Inflrmnrj, Glasgow Ur J H Halliard, Hedisinische Abteilung, Suva, Poatfach 6002, Luzern, Switzerland Prof C Multoni, Bologna Dr Hunts Mottlueei, Montedloon Hr Hokka, Neete Oy Ur D Honteeano, iarc, Lyons Ur A A Motli, Duperial SA1C, Buenos Aires Dr A Hunn, Monsanto, Brussels Mr M Munoz Mooton - Bio Rodano Hr S Nakamura, Japanese PVC Association Dr John J O'Sullivon Mond Dr n Owen - TUC Dr 0 H Puddle Dr S Psgllalungs - Montedison Dr liens Popper, Mount Sinai Medical Centre Ur J PoB&berg, Vacker Dr Junes Purdliaa - Canadian Centra for INIS Mr P Bsngnes, Norsk Hydro Dr B Sarscci, larc, Lyons Dr David Seronne, Diamond Sbaarock Dr Paul H Smith, Llandough Hospital Dr R Splrtas - HCI/H1H Bethesda Dr Carol Stack, CMA Vushington Dr J Stafford Mr Stehnecker, BASF Prof C II Taaburro - University of lx>uiaville Dr Gary Ter llasr. Ethyl Corporation Dr B Terwiesclt, CWH Dr Oilles Theriault - McGill University Prof Dr Thiess, BASF Dr E Thils - Evensen, Norsk Hydro Dr W Tordolr, Shell Dr T R Torkalson, Dow Hr J B Wallace, Eaoo Cheatcal, Sarnia, Canada Mr S 0 Wejdling, Kemanord Mr B N Wheeler, UCC Dr J Whiston, Hilihouse Mr K H White, Duperial SA1C, Buenos Aires Dr I W Williams, Norsk Hydro Dr P M J Willlasu, UP Barry Dr K S Wiliisason Dr Peter Wright, PEP Wilton X 3? Hr John fork, Everberg rn r> -0 fi if J o CL .0 y O 3 t\ b cr ( \v r 1 30 o(= JD m 03 O ro m cc m o RECEIVED FEB I 3 198a IMPEHIAI. CHEMICAL INDUSTRIES PLC PETROCHEMICALS AND PLASTICS DIVISION LIVER Ang loaurcoieu Cases - (Review Date: I Jan 1984) Ccramiy Sheet 1 Pax* It eoB tooooo a a * Q Q 11 1 |COUNTRY AND I REFERENCE I NO 1 GERMANY ( 09 1 1 1 t t 1 1 1 1 11 2 131 6 1 1 NAME OX | DATE OP INITIALS | SIXTH COHPAMY 1 I 1 1 |00.00.14 CWH 1 1 1 1 1 1 1 1 1 10 | (NIOSH glveal aa Case 1l)| 1 1 1 1 1 1 11 100.00 36 | CUII 11 11 11 11 11 11 11 1 1 |5 1f 1 1 | PACTORT 1 I 1 I 1 IHari 1 1 1 1 1 1 1 1 1 |Harl 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 6 FIRST VC EXPOSURE 20.02.61 1 1 | 1 1 1 1 1 1 1 1 DATE OP DIAGNOSIS 16.06.26 1 1 81 1 1 ACE AT t DIAGNOSIS | l 1 1 1 1 At | 1 1 1 l 1 1 1 1 I 00.01.77 1 1 1 1 1 1 1 1 _i-- 40 1 1 1 9 TEARS OE EXPOSURE TO DIAGNOSIS 19 1 16 l 1 1 1 1 1 1 1 1 i tt t 10 I 11 12 1 1) 1 14 1 i 11 1 1 TEARS OP | DATE OF EXPOSURE | HEATH 11 1 HISTOLOGICAL | ESTIMATED 1 1 CONFIRMATION I EXPOSURE | OCCUPATION | 1 | LEVEL 1 1 1 11 1 1 11 I 1 11 1 1 n 124 .03.7* Tee 11 1 (High peak* 112 yra poly-t 1 1 (worker lncl | 1 1 |I72 auto- | 1 1 (clave | 1 1 (cleaning | 1 1 IControl roo| 1 1 II yr 1 1 11 t 1 J!l 1l to 107.01.77 l Tea 1l 1l 1 1 1 (High peaka 1 1 1 -1 110 yra poly-1 |worker Incl ( 117X auto- | 1l 1l 1 I clave ( 1 (cleaning | 1l 11 1 1l 11 1 1i 11 I !l 11 1 n OTHER CAREER HIGHLIGHTS 16 | OTHER C'llHHENT S | 1 10/78 | (.'unllriKil | Average | vrpiiitaire II rut | 9 yra 130 |>|>*.l ore 1000 pp. | Neat 3 yi* v,( 73 p(K*. laec.l yr av 33 ppn | 1 |AvcraR |(.-si>.>aure f I ret (9 yea 130 ppw. |occ 1000 ppa. Il.atit yr av |73 ppia. CUII 11etter o( 121.04.78 1 1 II 1 |(NIOSH gtveal I aa Caae 10)1 t1 11 11 11 11 1 12 | 100.00.29 1 1 1 1 1 1 1 100.00.38 Hacker Oynaalc I Burg- | 10.10.33 11 11 11 11 11 11 |Trotedor(( 00.00.61 28.06.77 00.10.77 1 1 1 1 1 1 | 1 1 47 39 1 21 16 1 22 128.06.77 1 1 1t 1 11 1 11 1 11 1 11 1 11 1 11 1 6 (07.10.77 1 Tea Tea 1 High l 1 I 1 1 | 1 1t I 3 yra auto(clave leleaner 119 yra Ifllter (operator 1 i IfVC Hanu|facture |Autoclave |worker for 16 yra I I I I I I I I________ 1 l 1 1 1 1 1 1 1 1 IMPERIAL CHEMICAL INDUSTRIES PLC PETROCftF.MICALS AND PLASTICS D Ce runny Sheet 4 PaKc 12 11 |COUNTRY AND | REFERENCE | NU 1 1GERMANY 2| 1 NAME OR I INITIALS I 1 \ 1 3 _L OATE OP BIRTH 4 COM*ANY 15 1 1 | PACTORt 1 1 1 LIVER AngloasrctHsa Case* - (Review Date; 1 Jan 1984) 6 17 | JL FIRST VC I DATE OF | AGE AT EXPOSURE I DIAGNOSIS j DIAGNOSIS 11 11 11 11 9 1 10 ) n 1 12 1 13 1 14 1 11 11 1 TEARS OF I TEARS OF | DATE OF I HISTOLOGICAL | ESTIMATED 1 EXPOSURE TO ) EXPOSURE I DEATH I CONFIRMATION ( EXPOSURE I OCCUPATION l MACHOS IS 1 11 t LEVEL 1 1 I 11 11 11 1 1 1 1 11 11 t 15 OTHER CAREER llllilll. IGIITS 1 1 | I ( I 1 1 16 OTHER COMMENTS 1 1 ( | | 1 | | 1 1) 1 1 1 l4 1 1 1 | 1 1* 1 1 KNIOSN gtveal Ithla ii |Caa 13) 1 1 1 t 1 1 16 1 100.00 a M Lone* 1 1 1 1 1 J 1 1 1 1 1 1 1 1 1 i 1 1 1 \ i 1 1 1 1 100.00.29 Wacfcsr 1 1 1 1 1 1 1 1, 100.00.23 Dynaalt 1 1 1 1 1 1 1 1 1i i l Jl 11 lUilJlhut 1 00.00.60 I OB.04.70 | 1 ii 1 ii 1 ii 1 it 1 ii 1 _L 1 i i 1 ii 1 ii 1 I 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 1t 1 11 1 11 1l 1 1 1 1 11 1l 1 1 IRiirghauaen 19.10.53 I 09.10.70 | 1l 1 1 1l 1 1 1 11 11 1 1 1 11 1 11 1 11 J J. l--. --, * |Troiidorf| TOT7TT 1 0> .08.78| i ((Laibach | i (suspected | i |ASL at | i |F*b 1975 | i (lapstotu.y)l i 11 i 11 i 11 i 11 i 11 i 11 i \1 > 1 1 1 _! i !____________ L |.......... ....................( 63 49 55 1 1 1 18 25 }J 1 14 119.05.78 1 Ya | 1 11 1 1 11 I 1 11 I 1 11 1 1 11 1 1 11 1 1 INot ao | 1 | InglMircoai | 1 1 |In his letter | 1 1 (of 21 12 81. | 1 1 (Nr Frieds! | 1 1 (said this waa | 1 1 |a "Plattenepl-I 1 1 Ithelkarslno. | 1 1 |D*r | 1 1 (Speitierohre* | 1 1 |(a carclno.a | 1 1 |ef the 1 1 loeaoph.gua) | 1 1 loot ottrlbut- | 1 1 jable to VCM A | 1 > |not recognlaed| 1 1 |aa an Induat- | 1 1 |rlat dlseaas | ( 11 1 1 25 123.10.78 1 Tea | 1 11 1 1 11 1 1 11 1 1 11 \ 11 1 1 1 11 1 ( 11 1 l 11 1 20 (07.08.78 1 Yes | 1 1 |ASL and | 1 1 (Hepatocellular) 1 1 (Carclno.a | 1 (1 1 1 11 1 1 I1 ( 1 11 1 1 11 1 1 1t 1 1 1i 1 I 11 1 1 11 1 1 11 i j. J j____________ ______ I. High 1( 11 1I 1 tI 1 1( 1 1 11 11 1 1l 11 11 1l 11 11 1l 11 11 1l 1l 11 1t (Autoclave (cleaner and (worker. (Drier (operetor. ILeter shift 1 l l 1 1 1 1 | leader 1 11 11 I Autoclave |worker till (1964. |Leader and (.eater ( 1 1 1 1 1 ) 1 (i ! IF W Beat | I leIte r of | |30lh June 1980) (enclosing d.ila| (fro. | (Mr H P Frledeil lol BG C1ie.lt* I |F W Host (letter of | | 110th June 19801 (enclosing d.ita| (fro. | III F Frledcl ol| IBG Chu.le | (withdrawing (this cave | | 1I 11 11 l( 1I 1I 1I 1I 1I 11 | Anglosarco.a | Iconflr.ed | 109/79. Soso | (dot si 1 of till u| (A alao cases | (9, 13, 15, lb | (A 17 Riven In | (NRU Report for) 1 1978 IAngfnanrcona Icon!Irttd, (ful1 detsl1s (of 111 ness 1 | | | | (since March | 11973 Riven In | | NKW Hc.l | nw |i | | Hep lor I97. | 01| M runt | (delnl1M given | 1 In "VC | Aimr 1 .it fd | | | 01 st: il s<? ~ h y ( III... 1. ul 1 1,, rH i) |t/ . i w v 000003309 IMPERIAL CHEMICAL INDUSTRIE PI.C PETRI)CtlKHICAI.S AND PLASTICS I) VISION LIVER Angloaamoaa Canes - (Review Da Jan 1984) Ceraany Sheet 5 COUNTRY AND REFERENCE NO NAME OR INItlALS DATE OF BIRTH COHPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS CERMANV 17 (NIOSH given a* Cun* IS) 00.00.17 Dynanlt Troladorf 01.II.61 It.08.78 18 00.00.11 Hoechat Cendorf 00.00.55 25.12.79 19 00.00.25 Dynaelt Troladorf 18.10.54 00.08.79 20 00.00.15 Dynaelt Troladorf li.02.61 00.04.80 21 00.00.11 Dynaelt Troladorf 01.01.62 00.09.79 pronounced cltnlcal liver yatoea) 22 00.00.21 Dynaelt Troladorf 15.10.61 17-09-80 AOR AT DIAGNOSIS tl 66 54 65 66 59 YEARS OF EXPOSURE TO DIAGNOSIS 24 25 17 11 It 15 16 TEARS OF EXPOSURE I DATE OF I HISTOLOCICAL DEATH | CONFIRMATION 1 I 28.06.78 25.12.79 18 22.02.80 | Tee IHetaataelng (ASL I 19.10.80 I Tee IHaeeenglo )Endothelloee |af liver with IMetantaeee 19.06.00 I Tee lllaeeanglo |EndothelIona |of liver with x|Hctuutauea _________ 06.l2.fll 1' Yea |Hot .ml owing IASI. I ESTIMATED EXPOSURE LEVEL OCCUPATION High Autoclav* worker Autoclave marker OTHER CAREER HIGHLIGHTS _____ _ I | OTIIKK | COMMENTS | I I I I | Angtna.irrinaa |cnt tiicil. |Annual report (of the North |Rhlne lUcatpholfa 1 Hint teal | Inspectorate |fur 1978 Ipagea 347-377 (given lul I | Jut alia. Vinyl | chi nr I Ju HiaCii |df iiRiiosed 102-02-7). |Oea<i|ilinRca I Ivarlcea. I Rad lologlcally |cnfl(nvd acre |oaten!ynla High High High High Autoclave Marker Autoclave Worker Autoclave Worker and worked In drying shop Autoclave Ui.iker Cliarui'hiinJ, tUlt'Hl'l|IM!llt I y |Dr Bench* I letter of 111-04-1)2 to |0l W C P AJaaa I | Dr Beache (letter of 11 1-04-82 to | Dr U C F Allans I I |T>r Bench* lletter of 111-04-82 to | Ur w c P Ail .j4 I I i |>r IL-lilTl.' I letter ot | | 1 <14 - K 2 t > (III U I; p A.l,nb v w 000003310 IMPERIAL CHEMICAL INDUSTRIES PLC PETROCHEMICALS AND PLASTICS DIVISION LIVER Angloaarcuaa Caaea - (Review Date: Jan 1984) Should thta case bo removed froe the llatT N10SII have It on their eupplenenrery llat relating c<> non-po ynerlaatlon worker* exposed to VCM. JS 1/8 77 Page 14 I --- 3---------- COUNTRY AND REFERENCE NO ITALY 01 {On NIOSII supple mentary llat) NAME OR INITIALS DATE UP BIRTH IS.06.34 FIRST VC EXPOSURE 00.00.65 DATE OF DIAGNOSIS 19.04.71 AllE AT DIAGNOSIS 36 YEARS OF EXPOSURE TO DIAGNOSIS 06 10 YEARS OF EXPOSURE DATE OF DEATH 03 16.04.71 HISTOLOGICAL CONFIRMATION tYea n 14 I ESTIMATED | EXPOSURE | OCCUPATION LEVEL | 1 I I | FVC Bag (entruder I I OTHER CAREER HIGHLIGHTS OTHER COMMENTS Prlaary ttuanur ay have huvn perIcardInn. Not bnaogeuenna ultli other caucfl. a 02 13.11.29 Huntedleon Porto 00.00.57 13.12.72 43 IS 06 27.12.72 Yea Harghara 03 4.03.20 Solvay Ferrara 00.01.53 10.07.75 55 22 21 10.07.75 1 04 | F8 1 1 1 1 1 1 1 1 1 1 11 120.07.37 | 11 11 11 11 11 11 11 11 11 1t ANIC 1 |Ravenna 1 1 1 1 1 1 1 1 1 1 i1 | 00.04.59 | 00.01.81 1 t1 11 11 it I1 l1 I1 I1 l1 1 1 1 1 1 1 1 1 I 1 1 1 43 11 21 1 21 139.03.81 1 Vaa 11 11 11 11 11 1 11 11 11 11 1 11 1 11 1 11 _J_____ 1^ 1 1 J 05 |C Danealn | 9.03.37 Pansac 11 11 11 11 11 1 1 1 t 1 (Mira IVenlce ( 1 1 1 I1 1 I1 1 I1 JJ 1 J_ 11 1 I 00 00.67 | 07.03.83 1 11 1 11 1 11 11 1 ( 1 46 11 11 11 L________ ________ 1 11 16 8 106 04.83 ( Tea 11 11 11 (1 11 | ** See Hatton! Med ill laivoro 65 p445, 1974. Further detalla In letter /run Dr Munteaano of IAKC on April lit 1982. j *** | Alao ave Maltnnl and Koiidtnella In Acta Oncolog lea Vo I I 1980 page* 35 - 49. Engl Is' ' copies of the t runs I uL I on can lie made hv.iII.iMi- on rei|oi`S t ) . (|CI hint m.uIr a t ranvl at Ion of tlilu paper Into High I |Polyworker I J_________ I |Autocleaner |fl yra (1953' |6i) Autoclav (operator |I2 yra <1961 1972-5 did a variety ol Juba Including PVC pecking. 11 1 1 1 12 yra - 11 yr | Very High Ittonowr 1 (operator (Newer cleaned 1 (autnc 1 avea. 1 | See paper by 1 *** 1 5 yra - 1 |CIU Al'PINO et (Hon-aaoker. | Nedlua 120 yra - |al Hed Lavoro |Coneueed 1 1 * Yta | Autoclave |Vol 6 (1982) lllttle (operator 4 Ipp 555-561 (alcohol. No I Low (Other dutUij | AOL. 1 (In auapenv- 1 1 | Ion pulyaur -1 1 Illation. 1 1 1 1 1 1 1 1 i |He<llua-7 (High ( 1 1 1 |Area Forenanl |tn aaae Dept| (alnce 1975. 1 11 | Rag eat rudcr| (1967-1975 I (Cneaerclal | (Dept 1976- 1 (198) | 11 1 ( 1 1 1 Is Pag |1 llkgll (2 Aug ( 1 ( 1 " lulL'I 1983 Ol VVV 0 0 0 0 0 3 8 1 1 IMPERIAL CHEMICAL INDUSTRIES Pl.C PETROCHEMICALS AND PLASTICS DIVISION LIVER AngloBorcuaa Cases - (Review Date: I Jan 1904) Page It) J. I COUNTRY AND | NAME OR REFERENCE | INITIALS NO I DATE OF BIKTH COMPANY FACTORY JAPAN 02 I I I (Tonojl | Mori l I I I I I I I I J______ ISO ( t I I I 01.08.22 Mitsui Tostvu (no cpeeunt by Jap PVC Aaaoc) Nagoya 02.08.39 FIRST VC EXPOSURE 00.04.33 00.11.38 DATE OF DIAGNOSIS 24.10.73 10.08.76 ACE AT DIAGNOSIS 33 37 YEARS OF EXPOSURE TO DIAGNOSIS 17 10 12 t 13 14 YEARS OF EXPOSURE DATE OF DEATH 24.10.75 10.08.76 lI MISTOUICrCAL I ESTIMATED ( CONFIRMATION | EXPOSURE | OCCUPATION I __________________ I I I I LEVEL | I I I I irVC Aaaoc |I3 yrs auto- Iiiji not Iclave Iknown. (cleaner I* Japan (1964 - I Tines (assigned to (indicated (different ton 25.10.7 5|work since (exposures |had 111 loften at (health (3000 ppa u Pi |to 1974 I i I1 Yea (Not known | In polyner- I | lastlon work (Including (autoclave Icleanlng I 13 OTHER CAREER HIGHLIGHTS OTHER COMMENTS Jupan Tines 25.IH.75 4 Japanese PVC Aaeuc letter of 31.01.78 Japanese PVC Association letter el )1.03.78 In hla letter of 1st April 1982. Dr Monteseno of IARC asps Japanese Ministry of Labour give Data of diagnosis - 21-08-74 Aga of diagnosis - 52 Years of espoaura - 22 VVV 0 0 0 0 0 3 8 1 2 I VVV 0 0 0 0 0 3 B 1 3 {aunfiia.m i<>j]| t pr ** HDAt |lL *8u||i | |iu|| | iii'ii u| pca| DAd T HOAl 1`ail) dn-iJtt]a| | jo jnqM| 1 r la.i'j pi|| llIV irm l aauftocn d JHf | g*M au"r 6t ll *>H 3HrfV IV| 1 *IIN 1 M.-iaiiCAal 1 -aim ml | d( 11 11 11 11 11 11 11 11 11 11 11 11 11 1 JOI|Mllll|| | i|})nyi | * ua*ajoj| 11 M*IH 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 11 1 11 1 11 1 11 I 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 11 1 J I 2Z*l0**0l 12 I 1l 1 1 %1 l1 11 11 iI 11 11 11 11 11 11 11 1 l1 11 1 i1 22 95 l irzr 12 05 10*00 1 i 11 11 1 I\ 1 11 1 11 I1 1 11 1 11 1 1I 1 11 I 11 1 11 1 11 1 11 1 11 1 oipdH < 1 1 51*21 *121 I 1l 1 1 1 1 1 1 1 1 1 1 1 1 1 1 HV| 10 1 AvnxoN S1N3HH'0 N3ILLO 91 1 1 Slli:)i'inr>lii 1 xantivo 1 NtmVJftDDO 1 H4I110 1 1 1 51 1 l I3A31 svnsodxa aaivHixsa ci N0UVMMJN03 ivDioonoism 1 Hivati du aiva axnsodxa dO S3V3A sisoNovia ox axnsodxa JO SXV3JL 21 M 01 6 T TT1 1 sisormia si$i>N3via sunsodxa 1HOJOVJ 1 IV 33V jo aivo 3A 1SNIJ 1 I T1 s 9 5i 1HVJH03 9 T 1 1 HlttlS 1 jo aivu S1VUIH1 SO 3HVM 1 i 1C Z 11 OH 33HMJJ31 I 0MV HINDOO 1 1 t 1 ** 1 {`lfl6t uor I :a*"Q n|Aaa) - aaa3 ra*>ajuao|3uV HHAI1 MOIS1AIO SOUSVId (IHV S'lVSIHJtOOMiad 91 on saixisnoNi -ivoiHaio iviHjdwi IMPERIAL CHEMICAL INDUSTRIES PLC PKTHUCHEMt CALS AND PLASTICS DIVISION LIVER Angiosarcoma Caaee - (Review Dote: I Jan 1984) pne 7 n COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OP BIRTH 14 PIRST VC EXPOSURE DATE OP DIACNOS1S AUK AT DIACMOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE OATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER X I | OTHER CAREER | COMMENTS HIGHLIGHTS | I NU 13.06.27 Keaaiiord Sundavall I4.0R.S1 20.10.70 43 19 18 20.10.70 02 BL 27.II.I Keaanord Sundavall 00.01.45 00.08.72 27 16.06.72 Polyworker HI Rh VCH production 03 1 04 | AL 1 1 1 1 1 1 1 1 1 1 1 1 __J 03 10.06.10 Keaanord Sundaval1 00.03.47 16.03.76 11 lI 1 116. 11.14 | Keaanord |Sundaval1) 00.00.46 | 12.03.77 11 11 1 11 11 1 11 t1 1 11 11 1 11 11 1 11 11 11 11 1 11 11 1 11 11 1 11 11 k 11 11 1 11 1 1 ! _J J 1 1 t 1 1 1 1 1 1 1 1 1 1 1 1 1 12.03.19 Keaanord Sundaval1 11.03.64 22.11.80 63 62 61 29 21 19.03.76 High Polyworker 1 1 11 1 31 1 31 112 03.77 | Yea 1 High 11946-1938 1 1 1 1 Ipolyaer- I 1 1 1 Illation | 1 1 1 (worker (12 | 1 1 1 lyre) 4 1958-| 1 1 I 11977 foreman) 1 1 1 1(19 yra) 1 1 1 11 1 1 1 11 1 1 i 11 1 1 1 \k k 1 1 \1 1 11 11 1 ( -1 ) 1 16 16 22.1 1.80 High ~ 6 Yearn Low 10 Yeara 1964-1970 centrlluge operator 1970-1980 drier u|>.r I III or I |Nr S)oetin*a |lel ter of 128 Harm'll 1978 (conf tract BL |vm a monomer (worker wlio use |heavily (eipoeu.l, (probably even |aore eo than |u normal (reactor | cleaner J_____________ ( t In fIrat 12 ) yra of (employment had (been luiavl ly leapuued. In (1974. liver |abnoraalIt y land necrosis | .1 lag noecJ . |Data conf1 reed |in Dr D Byten 11 el ter 18.8.77 | la CH IC 1 I llettcr of | 2nd Nov I'lHI | f rim | Dr IMuld Kyi. I * In lila letter ot let April 1982, III Mmil *n;iiio nl I ARC ways In Sweden's N.il loiml IVxird of OS Ilia It I. Rlvea 20-02-70 nu dale <l .llaKiiiiKla r CM*... Ill mid IT US /t fix 117. VVV Q 000G 3314 IMPERIAL CHEMICAL INDUSTRIES PLC rETROCMKHtCALS ANI) PLASTICS DIVISION LIVER Angloaarcosia Caaea - (Review Dates I Jan 1984) UK Sheet > Page 18 12 |3 1 I COUNTRY ANI) | REFERENCE | NO 1 1 NAME OR | INITIALS | 1 DATE OP BIRTH UK 01 1 1 I 1 IV) 1 1 1 1 120.04.01 1 11 11 11 11 11 1 1 1 02 1 1 1 1 0) | BJV 1 1 1 1 1 1 1 102.06.3) 11 11 JJ 1 04 | JSR 1 123.06.20 11 11 11 11 11 11 11 11 11 11 11 11 11 11 4 COMPANY ICI P 131 6 1I | 11 1 i FIRST VC | FACTORY | EXPOSURE DATS OF DIAGNOSIS 6 Ace AT DIAGNOSIS 11 1| i1 ii II imtlhouacl 04.04.44 11 11 11 11 11 11 1) 11 03.12.22 ( Foa 4 Collier paper Bays) 23.12.72) 71 1 1 1 1 1 1 Barry t 1 1 1 1 | 00.02.66 00.12.74 37 11 JL 1l ICI |HlllHouae| 26.04.54 00.06.79 11 11 1t 11 11 11 11 11 11 11 11 11 11 11 59 9 YEARS OF EXPOSURE YO DIAGNOSIS 28 09 25 10 1 II 12 1 1 YEARS OP I EXPOSURE I DATE OF DEATH HISTOLOCtCAL CONFIRMATION 1 1 1 t 1 22 103.12.72 Tea 1 (Poa 6 I Collier Ipaper !*) 121.12.72)1 t 1 1------------------ 1 1 1 1 1 3.5 124.12.74 Yea 1 1 1 1 IS 112.10.79 Yea 1 1 1 1 1 1 1 1 1 1 1 1 1 I 13 1 14 1 13 11 11 ESTIMATED 1 | EXPOSURE i OCCUPATION | OTHER CAREER LEVEL I ) HIGHLIGHTS 1 1 || 500 ppa 11 11944-7 VCH 1 11947-8 Orler| 11946-61 1 I Autoclave 1 loperetor 1 11961-66 1 |Drier 1 11 1 1 11 11 11 11 High 1 I Autoclave leleaner 1 1 1 11 11 1 Medio*- 154-5 1 (Pre-war ftah high |Ragging I packer I Plant 11939-45 aray 155-6 IveMcle IDrler Plant leatncenance 156-56 11945-54 (Autoclave IflaH packer I worker (58-61 |Chargehend IDrler 1 Plant 161-72 1 1 1 1 1 |Foreuan 1 |C 2/3 Plant 1 I 1 1 >6 1 1 I OTHER | COMMKNTS 1 1 | 1 (lee and Harry I Lancet (29-06074 (pages 1316-B 1 1 1 1 l |Dublona | fair Icat 1 on |CHe 1 i IEaposure lllaltud to (2.66 - 9.69 1 1 \ 1 1 1 1 1 1 1 1 1 1 1 1 1 1 l 1 I I VVV 0 0 0 0 0 3 8 1 6 IMPERIAL CMEH CAL INIHISTRIKS PLC PETBOOIKHI CALS Nl) HAST ICS DIVISION UK Sheet 2 LIVER Ang obaicoaa Caaeu - (Review Date: Jen 1904) 1 12 ii1 4 COUNTRY AN( RE 'ERENCE NO UK 05 1 I NAME OH l | DATE OF 11 | INITIALS 1 MATH 1 11 11 | JK 1)0.01.14 COMPANY BP 11 1I 11 11 11 11 11 11 11 11 11 11 11 11 1 06 |CEP 1 I 19)1 BP 1 1 1 1 1 07 | RGB 1 1 1 1 1 1 1 126.04.20 1 1 BP 11 11 1 08 | UTH 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 108.05.24 1 1 1 1 1 1 1t 1 1 ) 1 1 1 1 1 1 1 1 1 1 1 BP 15 I 6 1 7 | 8 9 10 1 11 12 1 11 1 16 1 1) 1 11 1 1 FIRST VC | FACTORY EXPOSURE 1 DATE OF | ACE AT DIACNOSIS | DIAGNOSIS YEARS OK EXPOSURE TO 1 YEARS OF 1 DATE OF EXPOSURE I DEATH 1 1 HISTOLOGICAL I ESTIMATED 1 | CONFIRMATION | EXPOSURE ( OCCUPATION | OTHER CAREER 1 1 1 1 1 1 Barry 08.01.51 no.10.79 1 1 | 65 DIAGNOSIS 28 1 1 21 119.11.79 1 LEVEL l 11 1 11951-52 | IHCltl.lr.tlTS 1 11 11 11 1 1 |Potycleaner 1 1 11 11 11 1 1 11952-55 1 1 } 1 ILatei 1 1 i 1 11955-60 1 1 11 11 i IPolyfloor 1 1 i 1 11960-64 1 1 1t 11 1\ i 1 IPoly 1 i 1 (Chargeliaud 1 1 1 11964-70 1 1 11 i 1 |Charging 1 1 11 i 1 loperator 1 1 11 i 1 11970-72 I 1 1t t1 i 1 (Drier 1 1 I 1 (operator 1 1 1 1 Barry 1962 I 09.01.80 | 4879 18 i 12 109.01.80 11 1 1 |7 yre 1 | 1 1 1 1 IPoly Floor 1 1 11 1 1 (Operator 1 1 1 11 1 1 15 yra 1 1 11 1 1 (Creaaer on 1 1 11 I 1 IPoly Floor 1 1 |Barry 196) 00.00.80 | 60 17 82 111.06.80 1 IPolycleaner 1 1 1 11 1 1 11963-5 1 1 11 1 1 |Recovery 1 1 1 11 1 1 11965-1971 1 1 11 1 1 1 \ IBarry 1 11 19.09.50 27.11.81 | 57 31 11 1 24 125.12.81 1 \ 11950-1958 |S00 ppa 1 11950-51 lAutoclave 1t (19)8-1948 1 IHi.tor Hecltaiilcl 11 1 11968-1974 (operator (1948-1950 1 11 1 1200 ppa 11951-1957 (Operator on 1 11 1 IChargeaen |Acetylena 1 11 1 1 (autoclave | Product Ion 1 11 1 1 (building (Plant 1 1 11 1 1 11957-1974 1 \t 1 1 (Shift 1 1 11 11 1 1 (supervisor 1 1 1 1 (autoclave 1 1 11 11 11 1 1 |bu1IdIng - 1 1 1 1 |Never 1 1 1 1 (cleaned 1 1 11 1 l lautorlaveu 1 1 11 11 11 1 11 1 1 (hut 1 1 1 (supervisor1 | 1 1 1 |Jub eutnllcd| 1 t 1 tenter 1ng 1 1 1 1 |nut or levee 1 1 1 1 1 11 1 |t.. ItiNpert 1 1 11 l 1 11 lien 1 1 Page 19 16 OTHER CDMHKNTS IMPERIAL CHEMICAL INDUSTRIES PLC PETKOCKEMtCAl.S AN PLASTICS DIVISION UK Sheet 1 LIVER Angfoaarcoaa Caaea - (Review Date: I Jan IMA) 1 5 | 11 A COUNTRY AND REFERENCE 1 NANE OR | INITIALS 1 1 DATE OP 1 aihth | COWANY NO 1 11 UK 09 1 |EICP 11 IOY.05.Z5 1 BP I I II | I III j I III i | III | I 111 ! I III |I I I I II III ls 6 1 8 9 10 1 M 12 | --n-- 14 1 15 1 1 1 | FACTORY 1 FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURF. TO DtACNOSIS 1 TEARS OF I DATE OF EXPOSURE I DEATH 1 1 HISTOLOGICAL | CONFIRMATION | 1 ESTIMATED EXPOSURE LEVEL 1 I OCCUPATION I t OTHER CAREER HIGHLIGHTS | 1 1 1 1 1 11 1 1 1 Barry 15.02.50 02.05.8) 58 1) 29 124.02.83 Tea I Medina IFolyworVar |2 year* un 1 Acrylonitrile Kotin plant. II I I I III II lAlao prior to III III II II III III I I (1950. 4 years I I I RAP III III III II II II III III III I I |ulnteuance. I I 11 years aotor I I (car patntahup. II I II III I I I II III II II 12 years In ICmvtnK Dork. Page 20 16 OTHER COMMENTS W v 000003817 I IMPERIAL CHEMICAL INtJUSTRIES VLC PETROCHEMICALS AND PLASTICS DIVISION LIVER Angtoa.ircona Cases - (Review Date: I Jan 19H4) *UK syaten of date# DAY - MONTH - YEAR USA Sheet I PKC 21 COUNTRY AMO REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY FACTORY FIRST VC | DATE OF EXPOSURE | DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OP DEATH IIISTOIOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAKKEK HIGHLIGHTS OTHER COMMENTS USA 01 Earl Parka 17.10.21 02 9.00.33 l.oulavtlle I i 09.1 2.AH | 01.01.73 I I I I I I ---------- J- 03.01.73 l.oula- IS.I 1.55 | 00.05.70 37 14 13 27.09.71 vllle (NIOSH says 20.09.71) Pot Cleaner (Block Jane 1974) p 53 pot Cleaner (Cf Block) I lit slot y Riven | Kol I Iiir St one In Annals HY I Art ACAD SCIENCES JPc-f 1 NY Aoe.l VuI 179 (1979) (of Sc Syap page 19(1 lit 11914 Paper by |Albo Hlork E R Coctlne r>l IJaaa 1.7.74 OSIIA Ip 53 J____________ I jK.-f I | Also Block |JAHA 1.7.74 Ip 53 03 Edward 25.115.15 Loute- I 28.11.45 | 19.12.71 2B 19.12.73 Dinwiddle vtlle I I _______ !_______ I 04 15.01.24 BFC Louta- 06.07.52 | 19.OB.67 43 15 07.01.68 vllla I ______________ i______________ I 05 25.01.12 BFC Lonta- 19.06.44 | 09.04.64 52 20 20 09.04.64 vllla I 1 I 06 Ray 21.11.28 BFC louti- 17.01.62 | 00.02.74 45 12 12 24.07.75 Tea Austin vtlle I JoneaT 07 Chariea 13.05.22 T Snart S Charie 27.00.44 I 00.00.68 st on l 08 Goodyear Niagara 07.10.46 | 00.OB.61 I I 45 41 24 23.03.68 29.OK.61 Pat Cleaner (Cf Black) l.mil av I Me Courier Journal 02-09-B0 Pot Cleener (Cf Block) Pot Cleanar (Cf Block) US Air Force Pot Cleaner (Cf Block) I I Hof I | At au Block I I I I Ref I | At bo Block I 1 I Ref I | At bo Block I |Kuf 1 | I.mtlevl I le |Tinea 21.7.75 IHetlrcd April 11974 | Al no Bl ui k I I | Kel I I j________ I | He f I I VVV 0 0 0 0 0 3 8 1 8 IHFEMUL CHEMICAL INDUSTRIES PLC PETROCHEMICALS AMU PLASTICS 0 VISION LIVER Anglotarcoai Case* - (Review Da I Jan 190*) *UK syetaa of fatei 0AV - HOMTII - YEAR USA Sheet 2 Page 22 1 --------3--------------COUNTRY AND REFERENCE HO NAME OR INITIALS DATE OF BIRTH COMPANY 10 I* FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE OATE OF DEAYH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HICIII.ICHTS 16 OTHER COMMENTS 09 Raymond OB.11.11 Cettle- Finger? Louis 20.OS.41 01.01.74 4] 29 24 1.01.75 ville 2000 pp* I I 1 |Ref I ha* | wrung figures |re first leapoauie. | l.oulsvl | le I Tine* 129.10.74. 112.1.75, 110.1.76 10 I6.0B.I1 Coodjrear Niagara 12.06.51 00.05.6B 55 10.05.68 Ye* I | Kef I I 27.05.09 Coodjrear Niagara 14.10.46 00.01.70 61 21 16.01.70 Y*a | Ref 12 Francis A 17.11.18 FI teatone Pottatovn 11.07.49 02.05.69 50 20 19 02.05.69 Bachnan Pa High 10 yra 10 yra aa Utility 4 reactor op. Service op. I_____ I )Kef I + letter |of 26 April (not cleaner Raggvr II97B Irma - separate Dryer up. |Russel I A Park crew cleaned Stripping up. 11 u .1 T Seawall autoclaves) 1 yra prior |ut MCA aervli-e In I tyre plant | II Richard 01.12.21 Edward Clendenln S Charle 11.12.42 00.05.74 52 12 26 07.04.74 ston 2000 ppa I ______ I I Charleston I Dally Hall 121.7.75 J_________ I (Dubious IfsbrlcatInn lease I I 15 (Dubious I ( ahr (i ni |< I I I VVV 000003819 IMPERIAL CHEMICAL INDUSTRIES Pl.C PETHnr.HF.HICA1.S AND PLASTICS I) VISION LIVER AnglAMartoaa Cutea - (Riivlea Do e: ) Jan 1984) UK Spates of dates DAY - MONTH - YEAR USA Slice! 1 raise 21 COUNTRY AMU REFERENCE NO NAME OR INITIALS DATE OP BIKTH It Jaaea 04.11.2? RPC Howard Pcerenbooa 06.05.11 16 ChariI* 22.04.26 BPC Arthur FIRST VC EXPOSURE DATE OP DIAGNOSIS Loutavilla 08.05.50 00.00.64 Loulavllle 23.06.55 11.10.74 Avon Lake 15.09.54 00.00.75 AGP. AT DIACNOStS 43 46 YEARS OP EXPOSURE TO DIAGNOSIS 14 19 21 TEAMS OF EXPOSURE DATE OP DEATH 27.01.64 16.10.60 02.11.75 HISTOLOGICAL CONFIRMATION Tea an 11.10.74 but no poat-aortee 16.10.60 n 14 ESTIMATED EXPOSURE LEVEL OCCUPATION 1951-4 VCM po 1 yae r1 sal Ion 13 yra Navy autocleaner 6 yra on Eatol Tyre Store plaatlclaer 6 Carboaat operatIon OTHER CANKER HIGHLIGHTS l I | | | OTHER COMMENTS I I I Proa 1954 I |Table 4 I n onwards In |Wagoner Arajr and oilier | Test I Sony boivlce. |US Senate 46-50 Arsy | Coni Ire<l In |H N Johnson |Iir 07.08.76 I _______ I ||lr H H Johnson | let ter ol 124.2.81 ronII 1 raed rioutli |6 years af tec Idlagnoala________ ) ICnnflraed In |H N Joliiiaun jltr U7.U8.78 I Also Pel 11 ng (Stone aag. 115.01.76 I 19 Virgil 00.00.15 ucc S Charle- 00.00.43 19.06.75 60 32 32 06.04.76 Christian aton 20 31.06.17 Goodyear Niagara 00.00.55 10.01.76 21 Cheater 1)2.09.09 UCC Hinkle S Charla ton 00.12.46 Early 77 58 67 10.01.76 22 02.01.77 2000 ppa |UI11lasaport |Son Ornette 121 June 1975 (Charlvstun (Dally Hall |2I.7-/5 I_ I I HI OSH teller |of 25.10.79 I I |2H yrs wl t | iii:t: m sc j HetI red iH.-wh iel.il 12 I.2./7 I VVV 0 0 0 0 0 1 o 2 C IHPCKfAl. CHEMICAL INDUSTRIES PLC PETROCHEMICALS ANI> PLASTICS D VISION LIVER Angloaarcoaa Cases - (Review Da a: 1 Jan 1904) UK syatea of dates DAY - MONTH - YEAR Pae 24 10 12 n u COUNTRY AND | REFERENCE I NO I HAHE OR INITIALS USA I 22 ~fY 24 jCharlaa |Edward | Moore T23T DATE OP BIRTH 02.10.23 BPC FACTORY FIRST VC EXPOSURE OATE OP DIAGNOSIS ACE AT DIAGNOSIS YEARS OP EXPOSURE TO DlACHOSIS Loulsvllle II.07.47 00.01.76 52 29 00.007*3 17.05.17 Great Aasrlcsn Chealcal Ooapany UCC Fitchburg TSI.dOi Haas. S Charle ston 1919 06.04.73 27.05.77 35" 60 30 RcihiivmI from rci; eter emit rood lit R Ktmluokl let cr of 5 Nov oihc r | SHI) YEARS OF EXPOSURE 28 24T (HtOSH aya 26) DATE OP DEATH HISTOLOGICAL CONFIRMATION 04.(2.76 06.04.7f Tea 27.05.77 Cliotangioaarcuea ( Kaalnakl 26/2/79) KST1HATEO EXPOSURE LEVEL Nedlua to high for 24 yra | ION | | I OTHER CAREER IIICIIUCIITS | OTHER | COMMENTS I I | Intilavl I le |Tlaea 26.1.76 |aatd lie was (the IOth AS |vlet In at | Be 11 a Lane of |whoa B haJ Idled by 126.1.76 i In lila letter (of 16.09.01 |l)l H N Johnson Icutifiraa thla II a t lie (case described (by Dauniihcr IToalxirto 6 Yao jin Feb I9H0 |Aa J Medicine |Vol 70 p2B0 1941-65 non-|1937-39 was |N M Wheeler aolvent |off and on Matter ot vinyl realn llibnnret unit and |1939-^1 aay 110.0.77 to |J Stafford dispersion |have been Inlvea details vinyl reelna|eipoaed aa (Rose Kaminski nit first {reactor |letter of a fitter |cleaner 126/2/79 helper. then|!943 hecaae | It Kualnskl ahlft | alii I r fitter t(5 Mne I9HM) utility aan 11946 hecaae lauggeat* that liliirt utility INIOSH wll I |nan (retain on 126.04.65 |re|(later rlnci leap)itynent wai I till a ueopl asa 11 era Inn ted |nay be iiaaocl- | ed with AS)., |R N Wheel >r tlettvi ot | 2H/2/79 ail |Rnt.u Kami i>hl I | let t ft H i.l warn... VVV 0 0 0 0 0 3 8 2 1 IMPERIAL CHEMICAL 1 NltUSTK 1KS PLC PKTROCHKN1 CALS AN|> PLASTICS DIVISION LIVEK Angloaarcoaa Caaca - (Review Date; 1 Jan 1984) *UK ayatea of datea DAY - MONTH - YEAR USA Sheet 5 Page 25 11 11 1\ (COUNTRY AND I 1 REFERENCE 1 HO 1VSA | 1 | 1 2| 1 NAME OR | INITIALS | I 1 31 1 DATE OF 1 BIKTII 1 | 1 11 1 4 13 1 6 1 JL \ 1 1 FIRST VC 1 COM1ANY | FACTORY | EXPOSURE 1 11 1 11 1 1 7| l DATE OF | DIAGNOSIS | 1 | 8I ACE AT | DIAGNOSIS | 11 9 I 10 1 YEARS OF 1 1 YEARS OF | EXPOSURE TO 1 EXPOSURE | DIAGNOSIS 1 1 11 11 II 12 1 13 | 14 11 DATE OF 1 HISTOLOGICAL I ESTIMATED | DKA1M CONFIRMATION | EXPOSURE | OCCUPATION 1 1 LEVEL | 11 1 1 I | | I 15 OTHER CAREER HIGHLIGHTS 1 1 1 1 | 1 1 16 OTIIKK COMMENTS i 26 l.lohn Berry 103.07.23 1 RFC |Louis- | 03.10.47 00.00.77 | 52 1 28 1 i in.nj.n Yea (Exposed in |Various Job| | K Kiinl nuki i 1 1i |vllle | 1 (up to 2 | (death) | (death) 1 i i i 11 yeara I 1i i 11 11 after | 1i |aoaa Jegree|ln FVC |(o 22 Iplanta froa 1 (cheaicala (cold ruoa t<>| Metier of 17672/79 and IPiol. Taabiirrn i 1t 11 death) | 1i |but aaln Ipaate 1 Metier of i 11 11 1 1i lexpoaure |recovery to 1 M/l/79 i 11 11 i 1i |waa to VCM.IPVC charging! 1 i 11 11 1 I Iprobably (operator to 1 1 i 11 11 1 1i Ihlgh Ipaate 1 1 i I> 11 1 1 | (charging. 1 1 i 11 11 1 1i | |t11 Auguat 1 1 11 11 1 1 1 11965. 1 1 11 11 1 1i | CVcratnated 1 1 i 11 11 1 1i | leaployaent 1 1 i 11 11 ITT Mi.rt5.iS Ucc |S Charle-| jrnsTTT ,1 1i i irt62 I ---------- 57------------ li5.ll.7d Yea I |Jan 1966 1 1 | High |Operator to lEiposure In |R N Wheeler |Porreat | | iton | i KNIOSN 1 | |10.10.76 |billk and lire of 4 Jan 11 11 i laaya 27 11 (dlaperalun PVC|I979 and 11 11 i land C 1 lt |amn(acl ore |Charleston 11 1i j |Dally Hall} 11 1 lOally Hall 11 11 11 11 i i 125) 1 1 1 t1 11 1 t (30.M.7H and j H Ka*lnkl id 1111.04.17 ucc |S Charle-I 00.08.44 ,i 03.11.78 | 61 1 34 11 1 3) |03. M. 78 Yaa 1 1 1 1 1 1 176/2/79 |R Xaalnskl 11 | ItM | 1 1 11 1( 1 (letter i>t 29 | 1 112.10.07 1 UCC 11 |S Charla-I ooToTTT | aton | 00.03.80 1 | 1 22 1 38 11 1 16 101.03.80 1 Yea 1 1 1 1 I 1 1 1 1 16/4/79 |R Kualnakl lLetter* uf 11 t1 1 11 11 1 1191 li Juno 1980 11 1 11 14 5th Nov 1980 i Jd |WVN |22.07.i2 Tenneco |Flealngton ii.rtS.S4 30.12.80 | 58 | 1? 1 li 130.12.80 Yea |6 - UnknownIKatnfcsnancs t 1 11 Cheateala 1 1 I 11 |9 - Mlnlaal(Mechanic 1 1 > 1 11 11 1 i 1 11 11 1 [ 1 11 11 1 { 11 11 1 11 1t 11 11 1 16 yra 1 | IClaewhere 1 1 III yra 1 | IBoller hoiiae| 1 1 1 1 1 11 11 1 1 11 | |Oprtor 1 1 1 31 I 1 108.11.23 (ICC i1 |S Charle-| 12.05.46 1 01.08.81 | 52 | 35 11 1 13 102.04.82 Yea 1 19 yra |Hlgh (But IChtttlcil 11 IFroa 1959 to (Dr flncey i 11 | aton | 1 11 (not aa hlgli|Operatur In 11976 Al1 phutlc| letter 11 lt 1 11 |ae reactor (charge IChealcala 116.10.81 and 11 11 1 11 (cleaner (reactor (operator and |R N Wheeler <i 11 t1 1 11 (would | |froa July I976|ietler of <i <i i c> i o o o o uJ 11 11 11 11 11 11 11 || || 11 11 1! 11 11 11 11 1I |I i 1 1 \ 1 1 I | 11 11 11 l 11 11 l1 | 1| |experlenc}| |Worked aa | (labourer | If roa | | June 1941 | (to Miy I`)'i6( luml ojy (have Jr le.in. J | | | 11o dut e | Fotoiv.in |Aliphatic | Ghee 1 r A1 .............. . ....... 1 | 1 | 19.11.81. |Alo Dr Ihttry (leMer uf I07.IM.UI re |<|j(e of deJth. 1 | ( | CD | | M 1I NJ I| 1 1 ... | || 1 li.-.nl.,.,. 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H "T XC u re X ri ri >? CTj v: ffNJ i,' re re * * *c u-- c to C => -- CD 0c 5 re cc u c c *r re: * --r-e !--re T, u J oc J u rj o r*- eo sc c O' --M O CT' p CO 01 o a Xt_ a> N imTi\ONeoxo'0-Nn>jinvONOo\0r.<N(,,''5in^Ncooe'o0'-fri O' O' O' O' CD Z In c id e n c e o f ASL Cases P er Annum VW 000003625 Distribution of ASL Cases by Country USA W Germany France Canada UK Sweden Yugoslavia Italy Czechoslovakia Japan Belgium Norway 33 *** 21 ** j 7 *** 10 8 5 **** 4 ***** 4* 2 2 1 1 TABLE 2 (Review Date - 1 Jan 1984) Page 29 Total 108 * Omit ItOl - atypical case of PVC bag extruder. ** Includes GE03 aerosol can filler. *** Includes case US 24 which was diagnosed ns Cholanglosarcoma & US 33, 34 and 36; and F 15 and 16 who are alive **** Includes one monomer worker. ***** Includes two monomer workers. < "** i.e o ^ O o uJ CP Western Europe North America Rest of World 57 43 8 Tnt.il ton q Z B tO O O O O Pattern of ASL Cases by Factory TABLE 3 (Review Date - 1 Jan 1984) (a) W Europe Of the 57 cases In VI Europe, 46 have occurred in clusters at 10 factories. Of the 21 German cases, 18 have occurred In clusters at 4 factories. ASL Cases Kemanord, Sundsvall PCUK, Brlgnoud Dynamlt, Trolsdorf Chloe Chlmle (Formerly RP), St Fons Wacker, Burghausen CWH, Marl 1C1 Hlllhouse BP, Barry Soivay, Tavaux Lonza, Waldshut 5 5 10 8 4 2 2 6 2 2 46 Page 30 VVV 000003827 NB: There are 31 pre 1962 PVC plants In W Europe; 18 of these have had ASL cases (Ref Table 8) (b) N America Of the 43 cases in N America, 37 have occurred at four factories out of a total of 49 factories - in N America 39 plants have not had ASL cases. ASL Cases BFG, Shawlnlgan BFG, Louisville UCC, S Charleston Goodyear, Niagara 10 13 10 4 37 NB: There are 29 pre 1962 PVC plants in N America; 10 of these have had ASL cases (Ref Tables 9 & 10) (c) Rest of World 8 ASL cases are believed to be in 1 cluster of 4 ; 2 clusters of 2 cases.  CM W v 000003828 TABLE AA Latency Periods (Years from first Exposure to Diagnosis) (Review Date - 1 Jan 1984) N America W Europe BeIglum France Germany Italy Norway Sweden UK No of Cases 1 17 21 A 1 5 8 57 Total Years 18 438 385 74 22 122 189 1248 Average 18 25.76 * 18.3 * 18.5 22 24.5 23.62 21 .89 Rest of World US Canada 33 835 25.30 * 10 204 20.4 * 43 1039 Summary Czechoslovakia Japan Yugoslavia 2 2 4 8 30 15.0 39 19.5 85 21 .2 154 19.2 W Europe 57 1248 21.89 N America 43 1039 24.16 Rest of World 8 108 154 2^47 19.2 22.60 * Of the countries w!th!0 cases , France and USA have average 1atency period above world ave Page 31 0) breo o- oo O' \ V 4-1 a 4) > 0) fid 0) , CM areo uc C"! tr 'CJ l. it cc l/*> m OO CC CM cn fij 4J -- CM CM CM CM -- CM -- <9CM 0) U U~\ + irt C*1 re l > CM -5" o ci l r~> cn Li CO O' CM m CM cn Li V K > CM -- -- CM J CM cn u >> CM vC co to CM CM 00 CM O' CM Includes G 03 aerosol can f ilt e r -- -- -O I 09 Li >x O' I o re > o e 5 ** wCMrQ>e re rree c 6 CB o XNure u re CJ ruce h. >. ere LrEei <*r_-e<i m ere rae. r> re> 9u zo ere rree C?O u. c C/9 t-rMe <0 o areo >- J < H C H vVV 000003829 (Review date 1 January 1984) Page 33 TABLE 4C LATENCY PERIOD OFASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE 1 YEAR OF 1 LATENCY PERIOD ! ARITHMETIC MEAN 1l LATENCY PERIOD 1 FIRST EXPOSURE 1 1 OF LATENCY PERIODS 1I 1 44 1 1939 1 38* 43 1 1940 ! 42 1 1 1 37 ,21,37, 41 1 1 244 34.86 t7 41 1 2 1 32.38 1 40 1 3 1 38,14,32 I 1 4 1 28,11 ,24,20,24,34 , 391 718 - 26.59 1 5 1 27,22,28,29 1 27 1 6 1 21,29,31,26,28,15,23,1 1 1 30,35*** 1 36 I 7 1 29,24,29,28 1 35 1 8 1 28,24,34 | 1 9 1 30,26,20 I 458 * 24.11 1 1950 1 26,22,31,19,23,14,33 } 19 1 1 I 19,28,17,28 1 31 1 2 1 21**,15 1 30 1 3 1 25,22,23,22,20 ! 1 1 4 1 21,21,25,25,21,28***,! 1 i 22 1 . 592 m 21.14 1 5 1 22,23,24,14,19,21,27*r 28 1 I 27*** I i 1 6 1 21,12,27*** 1 26 1 7 1 19,17,15,13,16 1 25 1 8 1 18,18,15,17,20 1 1 9 1 16,21 I 328 * 16.4 I 1 1960 1 13,18 1 20 1 1 1 15,16,16,16,19,18,12 1 21 1 2 1 13,18,17,12 1 20 1 3 1 16,17 1 1 f 1 4 1 16,17 1 102 14.57 1 5 1 11 17 1 6 )9 1 16 1 7 1 16 1 15 I 8 ! ! 1 91 1 ! 1970 1 1 11 11 I 2 1 10 1 3 I J 4t 1 TOTAL 1 108 1 VIOLA 1 1 1 MALTONI 1 GOODRICH 1 2442 = 22.61 11 1 106 * Cholangiosareooa ** Aerosol can filler *** US33, 34 and 36; and F15 and 16 still alive. PJST80061400,!1/WPX7-2 vvv 000003Q30 (Review date 1 January 1984) Page 3^ TABLE 4D LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION MAX POSSIBLE 1 YEAR OF | LATENCY PERIODS IN LATENCY PERIOD 1 FIRST EXPOSURE 1 WESTERN EUROPE 11 44 1 1939 1 43 1940 1 42 1 1 I 37,41*** 41 1 21 40 1 3 1 36 4 1 28 1 NORTH AMERICA 1 1 38* 1 1 21,37 1 32,38 1 14,32 1 11,24,20,24,34,39 ROW 1 1 1 1 1 1 36 5 1 27 6 1 21,29,31,33 7 1 29 1 22,28,29 1 1 26,28,15,23,30,35*** 1 24,29,28 35 8 1 28,34 1 24 1 9 1 30,26 1950 1 26,22,31 1 20 1 19 1 23,14 | 31 30 1 1 1 19,28 2 1 21** 3 1 25,22 1 17,28 1 15 1 23 1! 22,20 1 4 1 21,21,25,25 1 21,28*** 22 I 5 1 `22,23,24,27*** 1 14,19,21,27*** 1 6 1 21,12 1 27*** 26 7 1 19,17,15,13 1 16 I 25 8 1 18,18 1 15 17,20 I 9 1 16,21 1 1960 1 13,18 I 1 1 15,16,16,16,19,18 1 12 21 2 1 13,18,17 1 12 20 3 1 16,17 1 4 i 16 1 17 5 1 11 1 16 1 6 t9 7 1 16 1 1 15 1 81 1 1 91 1 1 1 VIOLA 1970 i 1 1I 1 21 1 1 KALTONI 3 1 1 I II TOTAL 1 57 1 43 81 * Cholangiosarcoma ** Aerosol can filler *** US33, 34 and 36; and FI5 and 16 still alive PJST80061400,12/WPX7-2 ooqoo3831 Review date 1 January 1984) TABLE 4E Page ' PLANT START UP DATE LATENCY PERIODS OF ASL CASES NO OF CASES AV E RAG E LATENCY PEP.IOr LOUISVILLE SHAWINIGAN S CHARLESTON TROISDORF 1940? 1941? 1939? 1954 12, 14,15,19,19,20,24,27,28,28,28,29,29 11, 12,14,21,22,23,24,24,26,28 24, 30,32,32,34,35,37,38,38,39 12, 13,16,16,17,18,19,21,23,25 13 10 10 10 22.46 20.5 33.9 18 PJST80061400,13/WPX7-2 VVV 000003832 (Review dace 1 January 1984) Page TABLE 4F LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT YEAR OF FIRST I I EXPOSURE 1 S CHARLESTON 1 LOUISVILLE 1939 1 38 i 1940 1 I 1 37 i j 2 l 32,38 1 3 1 32 ! 4 1 24,34,39 l 20 51 l 28,29,27 6 ! 30,35 I 71 1 29.28 81 1 24 91 1 1950 1 1 19 11 21 1 1 15 3I 1 41 1 28 51 61 1 14,19 t 71 81 1 1 91 1 1960 1 1 11 1 2t I 12 to CM CM SHAWINIGAN 21 14 11,24 22 24 23 12 TROISDORF 21,25 23 12 13 16,16,19,18, 17 PJST80061400,14/WPX7-2 VVV OOGOO3833 (Review date l January 1984) Page TABLE 4G PLANT SUNLSVALL BRIGNOUD ST FONS 1 START-UP DATE 1 LATENCY PERIOD OF ASL CASES 11 11 f 1945 1 16,19,27,29,31 1 | 1950 1 11,16,18,26,30 1 | 1939 1 21,28,29,37,38,27,41,34 NO OF I AVERAGE PERIOD CASES I 1 5 | 24,4 years 5 i 20.2 8 1 31.88 BARRY I BURGHAUSEN NIAGARA SPLIT I 1 | 1 1 | 1 1948 1933 1947 1941 1 9,17,18,28,31,33 \ 1 17,21,22,25 1 1 15,17,21,23 1 1 1 20,20,22,23 1 6 t 22.66 4 1 21.25 1 4 1 19 1 1I 4 1 21.25 1 PJST80Q614Q0,15/WPX7-2 VVV 000003834 (Review date 1 January 1984) Page TABLE 4H LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLAN'. YEAR OF | FIRST EXPOSURE I SUNDSVALL 1939 1 1940 1 11 21 31 41 5 1 27* 6 1 31 7 1 29 81 9! 1950 1 1 1 19 21 31 4! 51 6f 71 81 91 1960 1 11 21 31 4 1 16 51 61 * Honomer workers BRIGNOUD 26,30 18 16 11 ST FONS 37 , 41 38 29 28,34 27 21 BARRY burgrausen 1 1 1 31,33 28 25 21 22 17 18 17 9 1 NIAGARA SPLIT ( 1 15,23 23* 17 20 22* 21 20 JS/JH/DSO 16 25 January 1984 PJST80061400,16/WPX7-2 VVV 000003835 1 25 | | i M a lto n l | i G oodrich | 1103 1 1 11 1 Key Events 1 11 a liv e * * Does n o t In c lu d e US33, 34 and 36; and F 15 and 16. A ll s t i l l o- m 01 n a. <0 w--o r* > 1 1 66 1 1 1 86 1 I ! vy 1 1 1 69 I 1 1 09 1 4) ^>4 ec 44 f_4 f-> 4n4 3O c CQ X EH 6 - CM <n -s- v CM LTl r" c CM <*1 ocno -S A* 'S' &< I my .C0) |4 44 ee C & tug tt 30H) o QJ u >01 cc OS e S CM m <n CM m m 00 iA e lA cn COT n il to date | n il to date j Rest o f W orld | 1 ! y O X 5 U - CO I - CM - J 1 I 44 cc X8J 00 4a2 --o 1 | N o rth Am erica 1 -- -- LTl CM - CM - CM * c"i Cl CM 1 "S' o - - o 44 .e3 o Vc. * o u w3 # e<c o e ^4 -- m y) vA r*. m vO s o cn u 444) o o S4B1 3 u 0! CO 1 55 C"l 09 0) X 1955 1970 r- CM S' >45 O' co O' - CM cn 'S m o rv oo C7\ CM 1980 TOTAL o c C8 6 1 1 1 1 | { VVV 000003636 (Review date 1 January 1984) Page 40 TABLE 6 ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING IT01) 1 KEY 1 1 11 t EVENTS 1 WESTERN EUROPE 1 NORTH AMERICA ! REST OF WORLD 1 1! 11 1 1955 \ Cl 1 6 11 7 l C2 1 8 11 9 11 1960 11 1 1 US8 1 2 1 C3 1 3 11 4 1 US5 1 Cz2 5 11 6 11 7 1 FI 11 B I C4,C5,US4,US7,US10 1 9 ( G1 ! US12,US16 1 1 Viola 1970 1 Swl 1 US11 1 1 I G2 1 C6,US2 1 2 1 N1,Sw2,UK1,It2 1 C7 1 IMaltoni 3 1 G3** I C8,US1,US3*US23 1 Yl,Y2,Czl lGoodrich 4 1 G4 * G5,UK3 1 C9.US13 1 5 1 F2F3,G6,G7,G8,It3 1 US6,US9,US18,US26 1 Japl 6 1 Bl,F4,F5,F6,F7,Sv3 I US 19,US20,US22, 1 Jap2,Y3 7 1 F8,F9,G10,Gll,G12,Sw4 ! CIO,US21,U$24* 1 1 8 \ F10.F11,G9,G13,G15 1 US27 US28 1 Y4 1 G16 G17 1 1 1 9 1 F12.F13,UK4,UK5,G18 1 ! 1980 1 UK6, UK7,G19 Sw5,G20,G21 1 US17, US29, US30, US32 1 1 1 It4 ,F14,UK8 G22 1 1 2 1 US31 I 3 1 UK09, It5, F17 1 US35 1 Total 1 55 -- | 40*** 18 11 * Cholangiosarcoma ** Aerosol can filler *** Does not include US33, 34 and 36; and F15 and 16. All still alive. PJST80061400,1/WPX7-2 VVV 0000033^7 (Review dace 1 January 1984) Page 4* TABLE 7 ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION* (EXCLUDING ITQ1) KEY j 1 I EVENTS I 1 WESTERN EUROPE 1 1t 1 11 i 1 1939 1 1 1 40 1 1 1 1 1Frl1,Frl6*** 1 I 21 1 1 3 1 Frl4 1 t 4 IUK1 1 1 5 1 Sv2 1 1 6 |Frl,Fr3,Sw4 1 1 7 |Sv3 1 1 8 1Fr9, Frl7 1 1 9 1 Frl2,Fr4 1 1 50 |Fr7,Nl,UK8,UK9 1 1 1 |Svl,UK5 1 1 2 IG3** 1 l 3 1G15,It3 1 1 4 107,08,0X4,019 1 1 5 1G11,G16,G18, Frl5*** t 1 6 IFR10.G1 1 1 7 |Fr8,G4,It2,G2 1 1 8 1Fr6,B1 1 1 9 |Fr2,It4 1 1 60 IG5.G13 I I 1 |G9,G10,G12,G17,G20,G22| 1 2 1G6,UK6,G21 1 1 3 IFr13, UK7 1 4 1 Sw5 1 1 1 5 1 Fr5 1 6 IUK3 1 1 1 7 i It5 1 1 81 1 1 91 1 Viola ! 70 1 1 1 1 11 112 1 1 | Maltoni | 31 1 11 1 Total 1 57 1 1 11 1 1 NORTH AMERICA | REST OF WORLD 1 US24* 1 t C3.US27 ! 1 US13, US29 1 C2.US19 1 ClC5,US5,US7,US28 ,US35 1 C4,US3,US9 1 C7,C9,US8,US11,US21,US31 1 C6,US22,US26 1 US1 1 US12 1 US 16 IY2, Cz2 US10, US32 t US4 CIO 1 |Japl,Y1 US18,US33*** US2,US17,US20,US34*** 1Y3 1 US36*** 1 iCzl US23 1Jap2,Y4 f 1 C8 1 US6 1 1 US30 1 1 I 1 1 1 1 1 | 1 1 43 18 1 * Cholangiosarcoma ** Aerosol can filler *** US33, 34 and 36; and Fr 15 and 16 are still alive. PJST80061400,2/WPX7-2 OOOOG3Q3a (Review date 1 January 1984) Page 42 TABLE 8 WESTERN EUROPE PVC FRCSXJCEFS - START-UP DATES vs ASL CASES (CMTimG G03) START--UP 1 COUNTRY NAJ-E TEAR 1 i * 1 1 1 LOCATION 1 I ASL CASE NUMBER 1 YEAR Or 1 1 1st Exrosure 1931 IWest Germany [BASF 1933 IWest Germany [Wacker [Ludwigshafen IBurghausen 1 104.07.11.15 1 [57,54,55,53 1938 1 Italy Ittontecatini lAcna 1 1 1939 [France 1 Rhone Poulenc 1 St Fons 103.09.10.11.14, 146,48,56,41,43, 11 1 115.16,17 155,41,48 1940 1 United Kingdom] Id [Runcorn 1 1 1940 1 limited Kingdom! ICI 1945 1 Sweden IKemanord (Hlllhouse 101,04 (44,54 1 Smdsvall( Stockvik) 101.02.03.04.05 151.45.47,46.64 1 (Switzerland [Lanza (Sins 1 1 1946 (France 1 Bhone-Poulenc (Rousillon 101 (46 1947 (Italy (l-txitedl&on 1 Porto Marghera 102 157 1948 (United KingdaalBP Qiem (Barry 103,05,06,07,08.09166,51,62,63,50,50 (West Germany [tills IMarl 109.10 161,61 1949 (Belgian 1950 (France ISolvic IFuk (Jemepce IBrignoud 101 158 102.04.05.06,12 159,49,65,58,49 [France [Rhone Ftaulenc (St Auban 107 150 (Holland [Shell literals 1 1 [Norway 1 Norsk IHeroya 101 150 1951 1 Italy 1 Montedison 1 Brindisi 1 1 1952 [Italy (Montedison [Terni 1 i 1953 [Austria IHalvic IHallein 1 1 1 France ISolvic [Tavaux 108,13 157,63 1Italy ISolvic (Ferrara 103 153 [Spain (Rio Fodano [Hemani 1 1 1 United Kingdom(BIP lAvcliffe 1 1 IWest Germany IHoechst IGendorf 118 155 1954 [West Germany [Dynamit [TroLsdorf (01,02,08,12,16, 156,57,54,61,55,61,1 [1 ! 117,19,20,21,22 154,61,62,61 1955 [Spain 1Monsanto Iberia1 Horizon I 1 1956 [Spain (Caiqsa ISabinanigo 1 1 1 (Hispavic [Torrelflvega 1 1 1958 (West Germany [Solvay [Rheinberg t 1 1960 [Italy IS C Ravenna (Ravenna 104 159 1960 IWest Germany (Lanza | Waldshjt 106,13 162,60 1962 1 Portugal [Clres 1Oporto 1 1 1965 1 France 1 Rhone-Faulenc IMontlucon 1 1 [Italy IPozzi [Ferrandina 1 1 IWest Germany (Wacker IGologne 1 1 1966 IWest German-/ (Hoechst IKnaosackC Frankfurt)[05* 160 1967 (France IAI0 Otimle 1 t1 (Spain (Rio Fodano (Miranda de Ebro I 1 (Greece (Esso Pappas [Dlavata Salonika 1 1 1968 IBelgiim IBadiphil (Antwerp 1 1 1969 llhited Kingdom IVinatex [Staveley 1 1 (Italy [Rumianca (Owllari SsrrrHna 1 1 1970 [Italy I SIR (Porto Torres Sar I i llbited KingdomI ICI (Runcorn 1 1 1971 [Italy IS C Ravenna (Ravenna 1 1 (Spain t Hispavic (Martorell 1 1 1 Sweden IKemanord (Sterungsund 1 1 [United KingdcnIBP Chen (Baglan Bav 1 1 1972 [Finland IPekema ISvartback 1 1 [Holland IDS* IBeek Iirturg 1 ! 1976 [France (Soc Art D'vinylIMazingarbe 1 1 1977 1 Spain 1Monsanto Iberia(Tarragona 1 1 * Laboratory worker in Research Department **Pansac,Mira Venice, case not included. (It 05) not knowing start up date of the Plant. PJST80061400,3/WPX7-2 03Q 39 (Review date 1 January 1984) Page TABLE 9 USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP 1 COMPANY NAME 1 LOCATION ) ASL CASE 1 YEAR OF YEAR 1 I NUMBER 1 1st EXPOSURE 1939? | *ucc i S Charleston 1 107,13,19,21,24 ,144,42,43,46,39, 127,28,29,31,35 141,44,42,46,44 1940? I *BFG 1 Louisville 101,02,03,04,05 ,148,55,45,52,4-., 1 106,09,16,17,22 ,162,45,50,55,47, 1 126.33,34 147,54,55 1946? 1*UCC 1 Texas Citv 1 1 1947 1 Goodyear 1 Niagara Falls 108.10,11,20 146,51.46,55 1948 1 Firestone 1 Pottstown 1 12 149 1 Uniroyal I Painesville 1 1 1 (closed 1975) 1 1 1950 1 Monsanto 1 Springfield 1 32 151 1952 1 Dow 1 Midland 1 1 1 BFG 1953 ! Diamond 1 Avon Lake | Deer Park 1 16 1 154 t 1954 1 General Tire 1 Ashtabula 1 36 156 1956 1 Air Products 1 Pensacola 1 1 1 Atlantic Refining 1 Brooklyn I 1 1 Borden 1 Leominster 1 1 1 Conoco 1 Hebronville 1 1 1 BFG 1 Niagara 1 1 1 Great American ! Fitchburg 123 158 I Plastics 1 11 I Hooker 1 Hicksville 1 1 1 Pantasote 1957 1 Atlantic Tubing I Passaic 1 Cranston 1 1 1 1 Tenneco ) Flemlngton NJ 1 30 159 1958 1 Keysor Century i Saugus, Cal t 1 1960 l BFG ! Watson, Cal 1 1 1 Air Products 1 Calvert City 1 1 1 (closed March 1982) 1 1 Borden t Illiopolis 1 1 1962 1 Tenneco I Burlington NJ 1 1 1963 1 Conoco | Aberdeen, Miss 1 1 1 Stauffer i Long Beach, Cal i 1 1965 1 Conoco 1 Assonet, Mass 1 1 1 Ethyl 1 Baton Rouge 1 1 1966 1 Diamond I Delaware City 1 1 1 General Tire/Pantasl Mt Pleasant W Va 1 1 1 BFG 1 Henry, 111 1 I 1 Stauffer 1967 I Allied 1 Delaware Citv 1 Painesville, 0 1 1 1 1 I (sold to Robintech) 1 1 Hooker 1 Burlington NJ 1 1 1968 1 Firestone 1 Perryville 1 1 1969 1 BFG } Pedrickton NJ 1 1 1 Goodyear 1 Plaquemine 1 1 1 Olin 1 Assonet, Mass 1 1 1 (Formerly Conoco)1 1971 t Conoco i Oklahoma City 1 1 1 1 i i j > > i j 1 PJST80061400,4/WPX7-2 000003840 vvv TABLE 9 (Continued) Page 44 USA PVC PRODUCERS - START-UP DATES vs ASL CASES 1 START-UP I ! YEAR | 1 1972 | 1 1973 I 11 11 11 i1 1! 1 1974 | t1 1 1975 I 11 1I 1 1979 1 COMPANY NAME Nat Starch Borden Robintecn Atlantic Tubing Shintech Certain-teed Georgia Pacific Tenneco Firestone 1 LOCATION 1 ! Meredosia, 111 } Springfield I Painesville, 0 | (sold to Georgia 1 Pacific who ] converted to ! polystyrene) I Cranston RI 1 Freeport, Tex 1 Lake Charles i Plaquemine, La 1 Pasadena, Tex 1 Plaquemine | 1 ASL CASE NUMBER 1 YEAR OF i 1st EXPOSURE 1 1 1 1 1 1 1 1 1 1 1 I * My databank has no Information on UCC before 1946 or BFG before 1950 NB Some of the plants in this list were closed down, some have changed ownership over the years PJST80061400,5/WPX7-2 VVV G00003tf<Vl (Review date 1 January 1984) Page TABLE 10 CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES I START-UP| COMPANY NAME i LOCATION I ASL CASE 1 YEAR Of 1 YEAR I ! 1 NUMBER 1 1st EXPOSURE 11 1 11 J 1943 | Goodrich 1 Shawinigan 101,02,03,04,05 144,43*41,45,44, 1(1941?) | 1 106,07,08,09,10 147,46,61,46,53 11 1 1] 11 1 11 1 1951 I Monsanto* 1 La Salle 1 1 1! 1 1I 1J 1 11 1 1957 | Goodrich 1 Welland 1 I !1 1 11 i1 1l 1 1966 | Esso ] Sarnia 1 1 11 1 11 1> 1 11 1 1979 | Diamond Shamrock Alb 1 Fort Saskatchewan 1 1 1I 1 11 * Terminated 1975 PJST80Q61400,6/WFX7-2 vvv 0OOO03 (Review date 1 January 1984) Page 45 TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES START-UP| COUNTRY NAME 1 COMPANY NAME YEAR 1 1 Pre 19391 East Germanv 1 State Company 1941 1 Russia 1 State Comps 1950 1 Yugoslavia iJugo Vinil 1951 1 Czechoslovakia 1 State Comps 1955 1 East Germany 1 State Comps 1956 I Rumania 1 State Comps 1957 1 Poland iState Comps |Rumania 1 State Comps 11 1958 1 Rumania 1959 I Hungary 1 State Comps 1 State Comps 1961 1 Rumania {State Comps 1963 1 Yugoslavia 1 Ohis 1965 1 Bulgaria 1 State Comps 1967 I Poland 1 State Comps 1969 1 Russia 1 State Comps 1970 1 Rumania 1 State Comps 1 Russia 1 State Comps 1972 I Yugoslavia 1Vinilplastika 1975 !Czechoslovakia 1 State Comps 1 Russia 1 State Comps 1976 1 Yugoslavia 1 Hip 1977 1 Rumania 1 State Comps 1 LOCATION l 1Schopau (Vladimir et al 1 Split 1Novaky 1Bitterfeldt tIcechim lOsweicim (Dwory) (Tirnaveni ITurda 1Risnov 1Berente Borsod 1Borzesti I Skopje 1 Varna 1Tarnow 1D1eriinsk 1Rimnicu Vilcea (Volgograd 1 Zadar 1Neratovice iKalush Area 1Pancevo (Rimnicu Vilcea ( ASL CASE | NUMBER 1 1 101,02,03,04 101,02 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 YEAR 07 1 1st Exposure ! 1 153,50,54,46 157,50 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 PJST80Q61400,7/WPX7-2 VVV 000003B^3 (Review date 1 January 1984) Page TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP I COMPANY NAME YEAR 1 1950 1 Chisso Corp I Kanegafuchi Kag I Tekkosha 1951 { Mitsui Toatsu 1952 1 Mitsubishi Mon 1 Sumitomo Kag 1951 ! Denkl Kagaku 1 Nippon Zeon 1 Toa Gosei 1955 1 Ryo-Nichi 1956 1 Nippon Zeon 1 Nisshin Kagaku 1957 1 Kureha Kasei ! Shinetsu Kag 1960 1 Denki Kagaku 1 Kanegafuchi Kag 1964 1 Chisso Corp 1966 1 Tokuyama Seksui 1967 1 San Arrow Kagak 1 Sumitomo Kag 1968 1 Ryo-Nichi 1 Shinetsu Kag 1970 1 Chisso Corp 1 Denki Kagaku I Kanegafuchi Kag 1 Kawasaki Yuki 1 Mitsui Toatsu 1 Nissan Kagaku 1 Shinetsu Kag 1971 1 Tekkosha 1973 1 Asahi Glass 1974 i Toyo Soda 1 1975 1 Central Kagaku 1 Toyo Soda 1977 1 Unknown 1 LOCATION 1 [ Minamata I Osaka 1 Sakata 1 Nagoya ! Yokkaichi 1 Klkumoto 1 Shibukawa ! Kambara 1 Tckushima 1 Uozu I Takoaka 1 Takeo ! Nishiki 1 Naoetsu \ Ohmi 1 Takasago I Chiba 1 Tokuyama 1 Tokuyama 1 Chiba 1 Mizushima 1 Tokuyama i Mizushima 1 Goi (Chiba) 1 Kashima 1 Kawasaki 1 Sakai 1 Chiba i Kashima 1 Yokkaichi 1 Hayatsuki I Sakata 1 Yokkaishi 1 Kawasaki 1 Yokkaichi l Kashima j ASL CASE ] NUMBER 1 1 1 1 01. 02 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 YEAR OF 1 1st EXPOSURE I t 1 I 53, 58 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I j ! 1 1 1 1 1 1 1 1 1 1 1 PJST80061400,8/WPX7-2 0000038** vvv (Review date 1 January 1984) Page 45 TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS 1 START-UP I 1 YEAR 1 1553 I 1954 1 1955 1 1956 1 1960 1 1961 1 1965 1 1966 1 1967 I 1968 1 1970 1 1971 1 1975 1 1976 1 1977 I 1978 1 1979 COMPANY NAME Monsanto Mexica Policyd Geon Do Brazil Elchlor Electrochlor Viplastic Indupa SOC Paramanga PET Columbiana Carburo De Col Plasticos Omega Primex Policasa Petro Dow Polimeros Mex Rico Chemicals Petroplas Indust Resistoc Huls Brasil Polychem Policyd PET Camacari | LOCATION 1 t 1 Lecheria (Mexico) I 1 1 Mexico City (Mexico) 1 1 Sao Paulo (Brazil) 1 1 Sao Caetano (Brazil) 1 ICapitan Bermudez(Argentina)I 1 Mendoz (Argentina) 1 i Cinco Saltos (Argentina) 1 1 Paramonga (Peru) 1 | Cartagena (Colombia) 1 1 Medellin (Colombia) 1 I Mexico 1 1 Puebla (Mexico) 1 ! Managua (Nicaragua) 1 | Conception (Chile) 1 1 St Martin Puebla (Mexico) I I Guyanllla (Puerto Rico) 1 1 EL Tablazo (Venezuela) 1 Tlazcala (Mexico) 1 I Cubato (Brazil) 1 1 El Salvador 1 1 Coatzacoalcos (Mexico) 1 1 Camacari Bahia (Brazil) 1 ASL CASE NUMBER I YEAR OF | 1st EXPOSURE 1 I 1 i 1 1 1 1 1 1 1 1 1 1 1 i 1 i 1 1 1 1 '61400,9/WPX7-2 VVV 000003845