Document v16KDM9oZoJdj4V2015da3Ynw
cnsanto
)* {namc. location) 5 . d . Eagleton -- LLN
12th November 1976 VINYL CHLORIDE encNct
3 R.N. Pittilo - Brussels
A. Munn - Brussels G.J. Levinskas - St. Louis ____
C_0_N_F_I_D_E_N_T_I_A_L
At a recent meeting of BIBRA Panel IV Dr. Lloyd gave some confidential information which should not go outside the company on the progress of the BIBRA VCM feeding trials with rats. The study was at its 9.7th week and vrill continue past the 104th week. Deaths started at the 90th week.
Level of VCM in water
250 25 2.5 0
pom " "
Males
Died
Tumours
17 2 90 90
17 0
Females
Died
Tumours
37 4 12 0 11 0 16 0
It is concluded that ingestion of VCM produces results similar to inhalation.
I thought you should know of these results and you will understand BIBRA1s desire to keep them confidential until the study is complete.
S.D. Eagleton
RSV 0018*96
AUTOIGNITION TEMPERATURE AND EXPLOSIVE LIMITS
OP COMMONLY USED CHEMICALS
HYDROCARBONS
EXPLOSIVE * LIMITS IN AIR
1/ 3 Butadiene n-hexane Varsol #2 Styrene Toluene 0-xylene
2.0-11.5% 1.2-7.5 1.1-6.0 1.1-6.1 1.3-7.0 1.0-6.0
HALOGENATED
Ethylene dichloride Trichloroethylene
6.2-15.9 .--
ALCOHOLS
n-butyl alcohol iso-butyl alcohol Tertbutyl alcohol Ethyl alcohol Ethylene glycol Methanol Phenol n-propyl alcohol Iso-propyl alcohol
1.4-11.2 1.7-10.9 2.4-8 4.3-19 3.2-? 7.3-36.5
2.1-13.5 2.0-12.0
ETHERS
Cellosolve (ethylene gycol monoethyl ether) Butyl cellosolve (ethylene gycol monobutyl ether) Methyl cellosolve (ethylene gycol monomethyl ether) i-Tetrahydrof uran Vinyl acetate
Diethyl.ether
Ethylene oxide
2.6-15.7
2.3-11.8 2.6-13.4 1.7-48 3-100
F * 804 500 450 914 947 867
775 770
689 800 892 793 775 867 1319 700 750
460
472
551
610 800 360 804
Dangerous Properties of Industrial Materials, 4th Ed., N. Irving Sax, Van Nostrand Reinhold Co., 1975
Issued: 12/79
Section:V-M
Page:
2 of
3
RSV 0018297
\*
E. ALDEHYDES AND KETONES
Acetone Methyl ethyl ketone (MEK) Cyclohexanone Formaldehyde
F. ACIDS AND DERIVATIVES
Acetic acid Ethyl acetate Maleic anhydride Stearic acid
G. OTHER
Acrylonitrile Triethanolamine Carbon disulfide
-2
EXPLOSIVE LIMITS IN AIR
2,6-12.8 1.8-10 1.1-? 7-73
5.4-16.0 2.5-9.0 1.4-7.1
3.1-17
1.3-44
F 1000 960 788 806
800 800 890 743
898 707 212
Issued: 12/79
Section: V-M Page: 3 of 3
RSV 0018298
SAFETY MANUAL
CONTAINER SIZE LIMITS FOR TOXIC VOLATILE MATERIALS IN THE RESEARCH BUILDINGS
.
VI - J
Hazardous Liquid Acrolein Acrylonitrile and Methacrylonitrile Allyl Alcohol Carbon Disulfide Benzene Cellosolves Bromine
VOLATILE LIQUIDS TLV* 0.5 ppm
20 5
20 35 25
1
Allowed Container Size 200 ml.
1 gal. 1000 ml. 1000 ml.
1 gal. 1 gal. 200 ml.
Threshold Limit Value.
Issued: 1-15-68 Revised:1-31-73 '
Section: VI Page : 2
J
RSV 0018299
SAFETY MANUAL
CONTAINER SIZE LIMITS FOR TOXIC VOLATILE MATERIALS
IN'/ihE Kr.b.ArtUti~ au'xLJli^CrS'
VI - J
CYLINDER GASES
Cylinder Size to be Allowed in Research Building
Density
Gas
#/ft.3
TLV*
Allowed Cylinder Size
Ammonia Arsine
22 100 ppm
13#
4
0.05
Special arrangements case***
Boron Trichloride Boron Trifluoride
3
1 1
1# 1/2#
Butadiene Chlorine
7 5**
1000 2-4
150
Fluorine
0.1 Special arrangements case***
Hydrogen Eromide Hydrogen Chloride Hydrogen Fluoride
Isobutylene
53 10 3 17 3
Same as Butadiene
4#
**# 1#
Methyl Acethylene
Ozone
Phosgene Phosphine
Same as Butadiene
0.1
4 0.1 10 0.3
Special arrangements case***
mn
n
Sulfur Dioxide Vinyl Chloride
6 6
5 500
5# ' 150
Threshold Limit Value.
Eased on 20-30 minute exposure effects whereas the remaining values "are standard 8 hou;? exposure values.
Use in any amount reauires consultatLon with Safety Committee.
Issued: 1-15-68 Revised: 1-31-73
Section: VI - J Pace: 3
RSV 0018300
SAFETY MANUAL
PEROXIDE FORMING CHEMICALS
VI-L
Some chemical compounds will react to form peroxides on aging. This can result in a dangerous situation, since peroxides tend to be explosive. Their safe handling requires the following precau
tions:
1. Purchase materials in small size containers - only the amount that can be used up in a short time.
2. Label each container with a special bright orange label, showing:
a. Date of receipt.
b. Date container opened.
c. Owner's name.
Labels are available in the Stockroom.
3. Dispose of material within two years of receipt or within one year after opening, whichever comes first.
4. No peroxide former (including vinyl monomers) should ever be distilled to dryness.
5. Upon completion of use, the container of a peroxide forming chemical should be purged with nitrogen (inert gas) prior to storage.
The following listing indicates the commonly used chemicals which readily form peroxides:
Acetal Allyl Ether Allyl Ethyl Ether Allyl Phenyl Ether iso-Amyl Ben2yl Ether n-Amyl Ether p--n-Amyloxybenzoyl Chloride Benzyl n-Butyl Ether
Benzyl Ether Benzyl Ethyl Ether Benzyl Methyl Ether Benzyl 1-Naohthvl Ether______
Bis (4-chlorobutyl) Ether Bis (2-chloroethyl) Ether Bis (chloromethyl) Ether (Carcinogen 1) 2--Bromoethyl Ethyl Ether t-Butvl Ethyl Ether t-Butyl Methyl Ether
n-Butyl Vinyl Ether Chloracetaldehvde Diethylacetal 2-Chlorobutadiene Chloromethyl Methyl -Ether Cyclohexene______________________
Issued:
7/11/72
Section:
VI-L
Revised:
1/4/78
Page:
1
RSV 0018301
SAFETY MANUAL
PEROXIDE FORMING CHEMICALS
Cyclooctene Decalin p-Dibenzyloxybenzene 1.2-Dibenzyloxyethane p-Di-n-Butoxybenzene 1.2-Dichloroethyl Ethyl Ether Diethoxvmethane 2.2-Diethoxypropane Diethyl Ether Diethyl Fumarate Diisopropyl Ether 1.1-Dimethoxyethane 1.2-Dimethoxyethane Dimethoxymethane 2.2-Dimethoxypropane Dioxane 1.3-Dioxepane Di-n-propoxymethane 1,2-Epoxy-3-isopropoxypropane 3-Ethoxypropionitrile
Ethyl Ether Ethyl Vinyl Ether n-Hexyl Ether Isoamyl Ether Isobutyl Vinyl Ether Isophorone
VI-L
beta-Isopropoxypropionitrile Isopropyl Ether beta-Methoxypropionitrile beta-beta-Oxydipropionitrile
n-Propyl Ether n-Propyl Isopropyl Ether Tetrahydrofuran Tetralin 1,3,3-Trimethoxypropene Vinylidene Chloride Isoamyl Benzyl Ether Vinyl Monomers
Issued: Revised:
7/11/72 1/4/78
Section: Paae:
VI-L 2
RSV 0018302
SAFETYMANUAL
WASTE CHEMICAL DISPOSAL
VII --A
X. Chemical wastes to be disposed under this procedure must be sealed tightly, in an appropriate container and labelled. The label should be Indelible and bear the name of the disposer, date, chemical name of material to be disposed, and most import antly, the chemical code group of the material. Waste labels are available in stockroom.
2. No material will be accepted for disposal without a chemical code grouping. Consult a knovledgable source of you are not' sure of the correct chemical code group of the material you wish to dispose. An incorrectly grouped chemical poses a potentially dangerous situation. The Chemical code groups are as follows;
CHEMICAL GROUPS:
Group A
1) Inorganic acids (Hydrochloric, sulfuric or ni trie acids . ) 2) Elements and inorganic salts that do not iibe rate gaseous
products when acidified, (eg. sodium chloride , barium silfate, magnesium nitrate.) 3) Psuedo-Metal compounds (As, Se, etc.), provid ing they will not liberate gaseous products upon contact wi th an acid.
Group B
1) Inorganic alkaline chemicals* (E.g. sodium hydroxide, anrnomium hydroxide).
2) Organic bases (e.g. pyridine, triethanol amine.) 3) Elements and inorganic salts that liberate gaseous products
when acidified (e.g. sodium sulfide.) 4) Heavy metals (Hg, Fe, Cu, etc. ) compounds. 5) Free and complex cyanides.
RSV 0018303
Group C
_-SoJ_id organic compounds, excluding organic acids and bases
(e.g. glucose, carbon, resins, etc. ). If possible, Group C drums should be separated in halogenated and non-ha 1ogenated materials.
10/5/6 7 Issued:
1/31/73, Revised:
7/9/79,
12/79,
8/4/80
Section: Pace:
V 11 -A 1 of"~4
SAFETY MANUAL
WASTE CHEMICAL DISPOSAL
VI1-A
Group D
Liquid organic compounds including organic -acids but excluding organic bases. (e.g. acetone, xylene, butyric acids.) Note: Peroxide forming materials must be stabilized prior to shipment.
Group E
Inorganic oxiding agents (e.g. bromine, chromerge, potassium & sodium perchlorates, chlorates, chlorites, dichromates, hypochlorites permanganate, persulfates, etc.)
Group F
Solid pesticides, insecticides, fungicides, etc. Not e: Each
pesticide & insecticide PLC will have to be reviewedon an individual basis.
Group G
Known and suspect, carcinogenic materials.
Not e: In case of a compound which might fit into two(2) di f f erent groups put it into the group based on the part of the molecule of higher toxicity. For example, lead acetate, lead would be Group B, the acetate portion is solid organic, Group C. It would go in Group B.
Group H
Waste oi1s,including oil from vacuum pumps, oil baths, mineral oils, lubricating oils, etc. all with flash points at or above 1 00 r .
EXCEPTIONS:
The following exceptions will not be allowed,(cannot be dis posed of by this Section V l 1-AT.T)
1) Shock sensitive materials (e.g. mercury fulminate, sodium azide, azide, azo-compounds, perchloric acid
. etc.)
Issued: 10/5/67_______________ Revised: 1/31/73,7/9/79,12/79,8/80
Section:711~A Pae.2 of 4
RSV 0018304
SAFETY MANUAL
WASTE CHEMICAL DISPOSAL
V11 -A
2) materials that are explosion hazards (e.g. dinitrobenzene, dinitrophenol, 4 dini t rophenylhydrazine, hydrazine, etc.)
3) materials that react violently with water producing heat and flame (e.g. sodium metal lithium, potassium, lithium hydride, sodium hydride, phosphorus trichloride, phosphorous pentachloride, phosphorus pentoxide, calcium carbide, etc.)
4) organc oxidizing agents, (e.g. bezoyl peroxide, methyl ethyl ketone peroxide, etc.)
5) pressurized gas containing cylinder (e.g. hydrogen
sulfide, etc.) 6) radioactive materials of any type 7) OSHA carcinogens, which include;
a Aerylonitri 1 e
j . Benzidine
b Benzene
k. 4-Aminodiphenyl
c Alpha-Naphthylamine
1 . Ethleneimine
d 4-Nit robiphenyl
m. Beta-Propiolactone
e 4,4'-Me t hy1en ebis
n. 2-Acetyl aminoflourene
(2-Chloroani1ine)(Syn.MOCA)
f Methyl Chloromethyl
o. N-Nit rosidimethylamine
Ether
S 3,31-Dichiorobenzidine p. Vinyl Chloride (and its salts)
h Bis-Chloromethyl Ether q. Coke Oven Emissions
i Beta-Naphthylamine
r. Di-B romoch1 orop ropane
3. After the waste chemical is all prepared for disposal, bring it to the Research stockroom.The Research stockroom clerk has access to the waste chemical drums,each of which is assigned to a specific chemical code group. The con tainer of waste chemical is placed intact into the approp riate drum, according to group. The drums are packed with
vermiculite.
4. The research stockroom clerk keeps a record of the contents of each chemical group waste drum in order to be able to provide a packing listfor the contract disposal firm at pick-up time. He has the responsibility of seeing that ail chemical wastes are disposed in conformance with this
-procedure in the appropriate group drum. However, the Research stockroom clerk is not responsible for classifying a waste chemical 'into its chemical code group; this is the e i V i- l j ty * f the rHcpngpr^-.Nn chemical waste ghern 1 d .
Issued:
J 045/67
Section: vii-A
Revised :i /^i /7? 7VQ/7Q i?/7Q /fin
Page: ^of4
RSV 0018305
SAFETY MANUAL
WASTE CHEMICAL DISPOSALVll-A
be disposed under this procedure without the knowledge of the Research stockroom clerk.
5- Five Gallon Pails or Drums
1. Non-toxic materials aT Crimp the top of the pail, or secure the drum bungs tightly.
b. Place the pail or drum in the Ahern Open Box Dumpst er.
2. Toxic Materials
a. Label the pail or drum with the chemical name date, amount of contents, name of disposer, and chemical code grouping.
b. Close container tightly so that contents will not leak out.
c. Bring container to the stockroom for handling, the same as in 3 above.
6. General Requirements
a. Under no circumstances will any material be added to a partly-full container in the disposal area.
b. All five gallon pails used for disposal must be equipped with lid having a plastic insert which will blow out to relieve pressure. (Available in stores).
c. All materials hauled out in the Dumpsters are dis posed of by land fill. It is esential that toxic obnoxious chemicals are not disposed in this manner.
d. Labeling and record keeping are essential require ments for proper application of this procedure.
e. For disposal of peroxides consult Section VI1-B and
contact a member of Hazardous chemical Advisory Board.
_ f- For disposal- of materials listed under EXEMPT IONS
contact member of Hazardous Chemical Advisorv B oa rd .
10/5/67
VII-A
Issued:__________________________
Section:
Revised: 1731/73-7/9/79,12/79.8/5/80
page. 4 of 4
RSV 0018306