Document v110k1Bx8BYwDJ90e4DEz5LQw
JAN J01975
THE DOW CHEMICAL COMPANY
January 27, 1975
BENNETT BUILDING 2030 DOW CENTER MIDLAND, MICHIGAN 48640
Mr. Milton Freifeld. Manufacturing Chemists' Assoc. 1825 Connecticute Ave, N.W. Washington, D.C. 20009
Dear Mr. Freifeld:
The attached table was compiled from information received over the telephone January 20, 1975. Dr. Keplinger of Industrial Bio Test wanted to know if the committee wished to sacrifice the surviving control mice and the 13 female rats exposed to 200 ppm. After talking to as many of you as I could get ahold of, I found that the majority preferred to keep the rats as long as possible and to main tain the mice at least for 18 months,
I informed Keplinger of this decision and he will keep these animals until notified otherwise. Therefore, about March 1 I will be contacting, you again on the disposition of the surviving control-mice. Since Maltoni has kept his animals for their entire life an d since you may be considering more studies at a later date, there appears to be reason to keep these animals for longer than the original protocol called for.
Note that it was necessary to sacrifice several moribund hamsters, mice and rats on January 20. All.exposed mice arc now gone as well as all the top dose of rats and virtually all the top dose hamsters.
There is no apparent explanation for the reversal in mortality of the groups of female hamsters. It`s just one of those things.
Sincerely yours.
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Theodore R. Torkelson Corporate Medical Department
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Vinyl Chloride Research Coordinators:
Dr. Zeb G. Bell, Jr. PPG Industries,, Inc. One Gateway Center Pittsburgh, PA 15222
Dr. Walter D. Harris
UNIROYAL, Inc.
Oxford Management Research Center
Middlebury, Conn.
06749
4
r 'M. N. Johnson, M.D.
The B.F. Goodrich Company .
Medical Center
500 South Main St. v? Akron, Ohio 44318
*
Mr. H. L. Kusnetz Shell Oil Company P.O.. Box 2463 Houston, TX 77001
Dr. W. Mayo Smith
Air Products 6 Chemicals
P.0. Box 538'
-
Allentown, PA 18104
Dr. William Rinehart Ethyl Corporation Medical Department 451 Tlorida Avenue Baton Rouge, LA 70801
Mr. R. N. Wheeler Union Carbide Corp. Chemicals Plastics P.0. Box 6004 S. Charleston, W. VA
Div. 25303
M. L. Keplinger Industrial BioTest Laboratories, 1810 Frontage Road Northbrook, ILL 60062
Inc.
J. Goode Industrial BioTest Laboratories, 1810 Frontage Road Northbrook, ILL 60062
Inc.
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