Document rxw01Y9xvg4JOEYn5KEq3ax7q

CONFIDENTIAL WORLD REGISTER OF CASKS OF ANGIOSARCOMA OF L IVKR (A S L) TH K REVIEW DATE 1 JANUARY 1988 ********* Collated by: __Dr Brian Bennett Occupational Health Department ICI Chemicals and Polymers Limited Hillhouse Site PO Box 4 Thornton-Cleveleys Blackpool FY4 4QD England (Telephone (Telex (Facsimile 0253 861632 ) 67483 ICIPLHG) 0253 861861 ) CMA 009941 Page 48 WPX/ASL2 - UNGIOCASES.23 (Review date 1 January 1988) TABLE 8 WESTERN EUROPE FVC PRODUCERS - START-UP CA1ES vs ASL CASES (CKETTING QD3 & Ic.OL) START-UPI OOUOTIQr NAME | OCWPANY NAME I LOCATION I ASL CASE NUMBER I YEAR OF YEAR | 1 1 1 | 1st Exposure 1931 iWtest Germany (BASF 1933 |West Germany |Wacker ILudwigshafen IBurghausen 1 |04,07,11,15,23,24157,54,55,53,55,69,60,5"3| 1 1938 1 Italy 1 IMontecatini 1 (Acna 125,31,32 1 |55 i 1939 I France 1Rhone-Poulenc/ |St Fons 103,09,10,11,14 146,48,56,41,43, I Khloe/Atochan 1 115,16,17 1940 I United KingdomIICI/EVC iPuncom (Closed 1948) 155,41,48 1 United Kingdom!ICI/EVC IHillhouse 101,04,12 144,54,57 1945 l&reden 1Ksnanord/Nobel ]Sundsvall(Stockvik)|01,02,03,04,05 151,45,47,46,64 1946 1 France |Rhone-Poulenc I Roussillon |01 146 1948 lUnited KingdoralBP Chan/ICI/EVClBarry 103,05,06,07,08,09166,51,62,63,50,50 11 1 110,11,13,14 166,65,68,66 |West Germany ICWH/Huls 1949 1 Belgian ISolvay I Marl iJemeppe 109,10,26,29 101,02 161,61,53,62 158,62 1950 1 France IPOJK/Atochem IBrignoud 102,04,05,06,12,19159,49,65,58,49,59,51 1 I France 11 I Rhone-Poulenc/ I Sc Auhan 120 107,22 1 150,58 I 1 Holland IGhloe/Atochan 1 1 Shell IPemis, Rotterdam i I Norway 1 Norsk iHeroya, Porsgmm 101 150 1951 1 Switzerland 1952 I Italy ILonza/ICI/EVC iSins 1 Montedison ITemi 1 1 1 Italy IMontedlson/EVC 1 Porto Marghera 102,06 157,60 1953 1Austria IHalvic/Solvay IHallein 1 I France ISolvay iTavaux 108,13,18 157,63,63 I Italy 1Solvay I Ferrara 103 153 1 Spain IRio Rodano IHemani I United Kingdan!BXL/BIP/NORSK. lAycliffe 1 I IWest Germany IHoechst IGendorf 118 155 1954 IWest Germany IDynanit Troisdorf 101,02,08,12,16,17 156,57,54,61,55,61, 11 1 119,20,21,22,27,30 154,61,62,61,55,51 1955 1 Spain I Monsanto Iberia IMonzon 1 1956 1 Spain ICalqsa ISahlnanlgo 1 1 | Hispavic/SolvayI Torrelavega 1 1958 IWest Germany ISolvay IRheinberg 1 1960 1 Italy _ |S C Ravenna/EVC IRavema |04 159 IWest Germany ILonza/ICI/EVC IWaldshit 106.13.28 162,60,60 1961 I Italy I Montedison/EVC I Brindisi 1 1962 1 Portugal I Clres 1Oporto 1 1965 1 France IRhone-Poulenc IMontlucon 121 159 1 Italy |PozzL IFerrandina 1 (Italy iPenaac IMira, Venice 105 167 IVfest Germany iWacker ICologne 1 1966 IWest Germany IHoechst 1 KnapeackC Frarkfurt) 105* 160 1967 I France |Atochem IBalan 1 I Spain |Rlo Rodano | Miranda de Ebro 1 I Greece |Esso Pappas IDiavata Salonika 1 1968 I Belgian iBadiphil I Antwerp 1 1969 1 United Kingdom! Vinatex/Norsk: |Staveley 1 I Italy | RunanLca/EVC I Cagliari Sardina 1 Continued CMA 009942 Table 8 - Continued WESTERN EUROPE PVC PRODUCERS - START UP DAZES vs ASL CASES (OKCTTPC G03 6 It,01) istakt-upi oounto n^me 1 CEMPANY 1 YEAR 1 1 1 1970 1 Italy I SIR 1 LOCATION 1 1 Porto Torres Sar I United Kingdom | ICI/EVC 1 Runcorn 1 1971 1 Spain 1Hispavie/Solvay t Martorell 1 Sweden 1Kananord/Morsk 1Stenungsund 1 United KingdanIBP Chan IBaglan Bay 1 1972 1 Finland |E\ekana ISvartback 1 Holland IDSM IBeek Limburg 1 1976 1 France ISoc Art D'vinyl|Maringarbe 1 l(CDF) | 1 1977 1 Spain 11-fonsanto Iberial Tarragona 1 1982 |West Germany 1 ICI/EVC IVoslapp 11 IWilhelnshaven 1 ASL CASE MJMBER | 11 11 11 11 1! 11 11 11 I1 11 |1 i1 i1 YEAR OF 1st Exposure * Laboratory worker in Research Department WPJt/ASI2 - LANGIOCASES.24 CMA 009943 Page 50 (Review date L January 1.988) TABLE 9 USA PVC PRODUCERS - START-UP DATES vs ASL CASES START-UP| COMPANY NAME YEAR_ 1 1939? I *ucc LOCATION S Charleston | ASL CASE 1 YEAR OF 1 NUMBER 1 1st EXPOSURE 107,13,19,21,24, 144,42,43, 46,39, 1940? 1 I Dow 1 I *BFG Midland (made Saran copolymer) Louisville 127,28,29.31.35 141,44.42. 46,44 |1 I1 101,02,03,04,05, 148,55,45, 52,44, I 106,09,16,17,22, 162,45,50, 55,47, 1946 1947 1948 1 I*UCC/Dow I Goodyear I Firestone/ 126,33.34,37.40 147,54,55, 53,42 Texas City (Partially closed 1977) 1 Niagara Falls 108,10,11,20.41 146,51,46. 5 5,? Pottstown |12 149 | Occidental | Uniroyal Painesville 1 | 1 1 1 1950 I Monsanto (closed 1975) Springfield I 132 1 1 51 1952 1 I Dow 1 BFG (Closed 1975 I Midland (No PVC since c 1975) Avon Lake |18 1 1 154 1953 1 Diamond/BFG 1954 1 General Tire/ ** Deer Park Ashtabula | |36 1 156 I DiversiTech (Closed 1984. Reopened 1986 by Vyg en) 1956 I Air Products Pensacola (Pace) I 1 I Atlantic Refining Brooklyn(Closed late 1960s) 1 I Borden Leominster (Closed 1984) 1 1 Conoco 1 BFG Hebronville (Closed 1975) Niagara | 1 1 | Great American Fitchburg 123 158 I Plastics (Closed 1983) I 1 | Hooker Hicksville (Closed 1980-81) 1 | Pantasote 1957 I Atlantic Tubing Passaic(Closed 1984) 39 Cranston (Jciosed 1967) 160 1 | Tenneco/ Flemington NJ I 30 159 1 Occidental (Closed 1985) I 1 1958 I Keysor Century Saugus, Cal I 1 I Air Products Calvert City(Paducah) 38 163 1 (Closed March 1982 Re-opened October 1983) 1960 1 BFG Long Beach, Cal (No PVC now. 1 1 Formerly shown as Watson) 1 1 Borden Illiopolis I I 1962 | Tenneco/Occidental Burlington NJ I 1 1963 I Conoco/Vista Aberdeen, Miss I 1 1 Stauffer Long Beach, Cal (Closed 1982) 1 H965 I Conoco/Olin Assonet, Mass (Closed by Olin 1975) 1 Ethyl Baton Rouge (Closed 1984) 1 1966 | Diamond/Georgia Delaware City I 1 I Gulf 11 IGen Tire/Pantasote Mt Pleasant W Va |(Closed 1982) 1 1 BFG Henry, 111 I 1 | Stauffer/Formosa Delaware City (Sold to Formosa 1981) 1967 I Allied/Robintech/ Painesville, 0. (No PVC made by Robintech, I Georgia Pacific 1 Hooker/Occidental GP converted to polystyrene) Burlington NJ 1 1 1 1968 1 Firestone/Occidental Perryville (Closed 1982) 1 WPX/ASL2 - LANGIOCASES,25 Continued CMA 009944 Page 51 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES I START-UP | I YEAR 1 I 1969~ I | I 1971 | 1 1972 | I 1973 1 I 1974 | | | I 1975 I | I | I 1979 | I I 1983 1 1 1986 | COMPANY NAME I BFG Goodyear/BFG 1 I | Conoco/Vista | Nat Starch | Borden | Atlantic Tubing/ | Tallyrand I Shintech Certain-teed I | Georgia Pacific/ | Georgia Gulf I Tenneco/Occidental| Firestone/ I Occidental | Formosa I Vygen ** I LOCATION Pedricktown NJ | ASL CASE 1 NUMBER I Plaquemine Oklahoma City Meredosia, 111 I I | Springfield | Cranston RI (Closed 1982) Freeport, Tex 1 | Lake Charles Plaquemine, La I I Pasadena, Tex 1 I Addis (formerly shown as Plaquemine) I Point Comfort, Tex| Ashtabula, Ohio I 1 YEAR OF | 1 1st EXPOSURE | 1 1 1 1 1 1 I 1 1 1 1 1 1 I I 1 * My databank has no information on UCC before 1946 or BFG before 1950 ** Refer to same plant at Ashtabula, bought by Vygen from DiversiTech. NB Some of the plants in this list were closed down, some have changed ownership over the years, some have changed their product. WFX/ASL2 - LANGIOCASES,26 CMA 009945 Page 52 (Review date l January 1988) TABLE 10 CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES I START-UP| I YEAR I 1I I 1943 | 1(1941?) | 11 11 1 1951 | 11 11 I 1957 | 11 11 1 1966 1 11 11 I 1979 | 11 COMPANY NAME | I Goodrich 1 | (Formerly Gulf) 1 Monsanto 1 1 I Goodrich 1 1 l I 1 Esso (Imperial Oil) | 1 1 Diamond Shamrock Alb/| BF Goodrich | LOCATION Shawinigan La Salle (Closed 1 ASL CASE I YEAR OF | 1 NUMBER | 1st EXPOSURE I 11 101,02,03,04,05 1 44,43,41,45,44, 1 106,07,08,09,10,1 47,46,61,46,53 I 111,12 | 7 7 ? 11 1975) | Welland (? 1 I Niagara) ! I | Sarnia Fort Saskatchewan 1 1 1 1 1 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES.27 CMA 009946 Page 53 (Review dace l January 1988) TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES START-UP | COUNTRY NAME | COMPANY NAME YEAR 1 1 Pre 1939 I East Germany |State Company 1941 |Russia I State Comps 1950 I Yugoslavia IJugo Vinil 1951 1955 | Czechoslovakia |State Comps |East Germany I State Comps 1956 I Rumania 1957 |Poland |State Comps I State Comps |Rumania |State Comps 1958 1959 1 I Rumania I Hungary 1 I State Comps I State Comps 1961 |Rumania |State Comps 1963 I Yugoslavia lOhis 1965 I Bulgaria |State Coraps 1967 1 Poland I State Comps 1969 |Russia I State Comps 1970 I Rumania |State Comps I Russia |State Comps 1972 I Yugoslavia |Vinilplastika 1975 |Czechoslovakia |State Comps 1 Russia I State Comps 1976 I Yugoslavia 1 Hip 1977 |Rumania (State Comps | LOCATION 1 1 Schopau IVladimir et al I Split |Novaky IBitterfeldt | Icechitn lOsweicim (Dwory) |Tirnaveni ITurda |Risnov |Berente Borsod |Borzesti 1 Skopje |Varna |Tarnow IDjerlinsk |Rimnicu Vilcea (Volgograd I Zadar INeratovice IKalush Area |Pancevo IRimnicu Vilcea 1 ASL CASE I NUMBER 1 1 101,02,03,04 101,02 1 1 1 1 1 1 1 1 1 1 1 ! 1 1 1 1 1 1 | YEAR OF I 1st Exposure 1 1 153,50,54,48 157,50 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 WPX/ASL2 - LANGIOCASES,28 Cii* 0099A? Page 54 (Review dace 1 January 1988) TABLE 12 JAPANESE PVC PRODUCERS - START-UP DATES vs ASL CASES |START-UP| I YEAR 1 I 1950 1 1 1 1 1951 1 1 1952 1 1 I 1951 1 1 I I 1955 1 1 1956 1 1 I 1957 1 1 1 1960 I 1 I 1964 1 1 1966 1 1 1967 1 1 1 1968 1 1 I 1970 1 1 1 1 1 1 1 I 1971 1 1 1973 1 1 1974 1 1 1 1975 1 _1977 I I 1 COMPANY NAME Chisso Corp Kanegafucht Kag Tekkosha Mitsui ToaCsu Mitsubishi Mon Sumitomo Kag Denki Kagaku Nippon Zeon Toa Gosei Ryo-Nichl Nippon Zeon Nisshin Kagaku Kureha Kasei Shinetsu Kag Denki Kagaku Kanegafuchi Kag Chisso Corp Tokuyama Seksui San Arrow Kagak Sumitomo Kag Ryo-Nichi Shinetsu Kag Chisso Corp Denki Kagaku Kanegafuchi Kag Kawasaki Yuki Mitsui Toatsu Nissan Kagaku Shinetsu Kag Tekkosha Asahl Glass Toyo Soda Central Kagaku Toyo Soda Unknown I LOCATION 1 1 Minamata ! Osaka 1 Sakata 1 Nagoya I Yokkaichi 1 Kikumoto I Shibukawa I Kambara I Tckushima 1 Uozu I Takoaka 1 Takeo I Nishiki | Naoetsu 1 Ohmi I Takasago I Chiba 1 Tokuyama 1 Tokuyama 1 Chiba I Mizushima 1 Tokuyama I Mizushima I Goi (Chiba) I Kashima | Kawasaki 1 Sakai I Chiba | Kashima 1 Yokkaichi I Hayatsuki | Sakata I Yokkaishi | Kawasaki I Yokkaichi I Kashima 1 ASL CASE 1 NUMBER 1 I 02 1 1 01, 03 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 YEAR OF 1 1st EXPOSURE 1 1 58 I I 53, 6 5 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 ! 1 WPX/ASL2 - LANGIOCASES,29 CMA 009948 Page 55 (Review date 1 January 1988) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS |START-UP| | YEAR 1 I 19 53 1 I 1954 1 | 1955 1 1 19 56 1 | 1960 1 1 | 1961 1 | 1965 1 I 1966" 1 1 1967 1 ! 1 1968 1 | 1970 1 1 1 1971 1 | 1975 1 I 1976 1 1 1977 1 I 1978 1 1 1 | 1979 1 COMPANY NAME Monsanto Mexica Policyd Geon Do Brazil Elchlor/Solvay Electrochlor Viplastic Indupa PET Columbiana Carburo De Col Plasticos Omega SOC Paramonga Primex Policasa Petro Dow Polimeros Mex Rico Chemicals Petroplas Indust Resistoc Huls Brasil Polychem Policyd PET Camacari 1 LOCATION 1 11 | Lecheria (Mexico) 1 I Mexico City (Mexico) 1 I Sao Paulo (Brazil) 1 I Sao Gaetano (Brazil) 1 ICapitan Bermudez(Argentina) 1 I Mendoz (Argentina) | Cinco Saltos (Argentina) 1 1 I Cartagena (Colombia) I Medellin (Colombia) 1 1 I Mexico 1 I Paramonga (Peru) 1 | Puebla (Mexico) 1 I Managua (Nicaragua) 1 I Conception (Chile) 1 1 St Martin Puebla (Mexico) 1 1 Guyanilla (Puerto Rico) 1 I EL Tablazo (Venezuela) I Tlazcala (Mexico) 1 1 | Cubato (Brazil) 1 | El Salvador 1 1 Coatzacoalcos (Mexico) I Camacari Bahia (Brazil) 1 1 ASL CASE NUMBER 1 YEAR OF I 1st EXPOSURE 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 | 1 I WPX/ASL2 - LANGIOCASES,30 CMA 00994? Page 56 (Review date 1 January 1988) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP DATES START-UP | COMPANY NAME YEAR | 1 Mid 1950s | ICI Australia 1 1960s | B F Goodrich I Late 1970s t ICI Australia i i 1 LOCATION | 11 11 I Botany, Sydney | 1 1 Melbourne 1 | 1 | laverton 1 | | Melbourne | 11 ASL CASE NUMBER 1 YEAR OF | 1 1st EXPOSURE | 1 1 1 ! 1 1 i i WPX/ASL2 - LANGI0CASES.31 009950 Page 57 (Revtew date 1 January 1988) TABLE 15 MIDDLE EASTERN PVC PRODUCERS START-UP DATES START-UP DATE Sept 1986 COUNTRY NAME Saudi Arabia COMPANY NAME ___________ I I LOCATION National Plastic I Arabian Petrochemical Company Company IMadiant (IbnHayan) lAl-Jubail IAl-Sinahyah WFX/ASL2 - LANGIOCASES,32 CMA 009951 Count ry: countk* ahu REFERENCE NO NAHE OK INITIALS DATE OF BIRTH let CHEMICALS A POLYMERS LIVER Angiosarcoma Cases (Review Date: I Jan 19 |6 J | 7 i a 19 l to 1 ii 1 12 i n i h 1 L*i i 1 |YEARS OP { i IHISTO- l i l IS | 11 l1 IFIRST VC |DATE OF (ACE AT (EXPOSURE J YEARS OF( DATE OP | LOGICAL J ESTIMATED^ |OTHER 1 IKXPOSUU J 01ACN0SIS1 DIAGNOSIS!TO | EXPOSUREI 11 |DIACN0S1S| jJ JL * DEATH l CONFIRM -| EXPOSURE |OCCUPATION (CAREER | |ATION J | LEVEL 1 l 1 1 HIGHLIGHTS| l1 WPA/ASL - LAMCIOCASES.IJ i lb OTHER COMMENTS o 3; > oo *0 'O w M TACHECI Dr H TAMBURSD Prof ffl ten BERCE Dr W F IENKH0FF Dr N TEPPER Dr L B TER HAAR Dr Gary TERWIESCH Dr B THERIAULT Dr Gilles THIESS Prof Dr A M THIIS-EVENSEN Dr E THOMSON Dr D H TONER H P VAN DER MERWE Dr H J WALLACE J R WALTEMA3E H WEJDLING S 0 WHITE K H WILDJSKI 0 WILLIAMS Dr DrtJ WILSON Prof R WRIGHT Dr A P YORK J -3- Hoechst PC, Frankfurt, Germany University of Louisville, USA Dl, Geleen, Holland tills PC, Sfarl, Germany Air Products, Allentcwn, Pennsylvania, USA Ethyl Corporation, Baton Rouge, Louisiana, USA Chemische Warice Huls, Kreis Recklinghausen, Germany McGill University, Montreal, Canada BASF, Ludwigshhafen, Germany Norsk Hydro, Porsgrunn, Norway Cancer Treatment & Research Foundation, Halifax, NS, Canada Society of the Plastics Industry, Vfeshingtcn DC, USA AECI, Sasolburg, South Africa Esso, Samia, Ontario, Canada BF Goodrich, Qeveland, Ohio, Usa Norsk Hydro, Stenungsund, Sweden Duperial, Buenos Aires, Argentina ELectrocherical Industries, Pcre, Israel BP Chemicals, Penarth, UK Harvard University, Canbridge, Massachusetts, USA Id Wilton, UK ICI Everberg, Belgium From: Dr B Bennett, Occupational Health Department, ICI Chari.cals & Etolymers Group, Hillhouse Site, PO Box 4, Thomton-Cleveleys, Blackpool FY5 4QD, England WPX/ASL - ASL ADDRESS,3 CMA 009953 CONFIDENTIAL REGISTER OF CASES OF ANGIOSARCOMA OF THE LIVER DUE TO EXPOSURE TO VINYL CHLORIDE - REVIEW DATE 1 JANUARY 1988 PREFACE : ACKNOWLEDGMENTS, SIGNIFICANT CHANGES, COMMENTS AND REQUESTS 1 The 8 new cases in the Register are the following: Canada 11 and 12; France 22; Italy 06;Japan 03; UK|l4; US 40 and 41. 2 There are amendments from the previous Register against the following cases: Japan 01 and 02. 3 I would like to thank the following for informing me of new cases: Dr Delorme, Dr Contassot, Dr Chiozzini, Dr Nakamura, Dr Evans, Dr Williams, Dr Dietz, and Professor Tamburro. 4 For the case corrections I thank Dr Nakamura. 3 It will be noted that there are gaps in our knowledge of several cases, notably Canada 11 and 12and US 41. Also, so far as we know the following people are 6till alive: cases Canada 11, France 15 and 22, Germany 31 and 32, UK 14, US 33, 36, 41. Is this correct? This is important information for the industry world-wide fund we would appreciate news. 6 I should be glad if all recipients of the Register would continue to keep me fully informed of any new cases, or give the name and address of someone who can give me the necessary details. I have again attached a blank sheet at the back of the Register so that information can be supplied under the appropriate headings, so far as possible. 7 As a result of the request sent with last year's Register, regarding Co-factors, we received a great deal of information about PVC Plants, which has resulted in many amendments to Tables 8, 9, 10 and 13. Further corrections will be appreciated, bearing in mind that the Tables are confined to PVC. 8 RESEARCH: (a) May I again ask that all individuals involved in relevant research keep me informed and if possible send me reports. Perhaps recipients of this Register would pass on my request. (b) Co-factors: In response to the questionnaire enclosed with the 198? Register, regarding possible co factors with Vinyl Chloride, I received replies from 26 Companies, covering 61 factories. This material is now being analysed by Professor Carlo Tamburro at the University of Louisville, Kentucky, USA, and w shall report on the results as soon a6 possible. We are extremely grateful to all who took the trouble to give this information. If any Company has not yet completed the Co-factor questionnaire I should be grateful if it could be completed and sent back to me as soon as possible. 9 I would also be glad of help to keep the mailing list correct and up to date, with news of retirements, etc. FROM: Dr Brian Bennett, Occupational Health Department, ICI Chemicals and Polymers Limited Hillhouse Site, P 0 Box 4, Thornton-Cleveleys, Blackpool-, FY5 4QD, England tn February 1988 * BB/BGS CMA 0 0 9 ? ICI CHEMICALS & POLYMEKS WPX/ASO - LANG10CASES.4 Index LIVER ANGIOSARCOMA CASES (REVIEW DATE - 1 JANUARY 1988) Table Sequence Belgium 1 Canada Czechoslovakia France Germany Italy Japan Norway Sweden UK USA Yugoslavia Incidence of Cases per annum (Table 1) Distribution of Cases by Country (Table 2) Pattern of Cases by Factory (Table 3) Page 1 2-3 4 5-9 10-15 16-17 18 19 20 21-24 25-32 33 34 35 36 ASL Case Numbers by year of Death (Table 6) 1 ASL Case Numbers by year of first exposure (Table 7) Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8) USA PVC Producers - Start-up Dates vs ASL Cases (Table 9) Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10) East European PVC Producers - Start-up Dates vs ASL Cases (Table 11) Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12) South & Central American PVC Producers - Start-Up Dates (Table 13) Australasian PVC Producers - Start-up Dates (Table 14) Middle Eastern PVC Producers - Start-up Dates (Table 15) Blank form for notifying new cases Page 46 47 48-49 50-51 52 53 54 55 56 57 - CMrt 0 0 9 9 5 5 Latency Periods (Table 4A) 37 Distribution of Latency Periods (Tables 4B-4H) Annual Geographical Incidence (Table 3) 38-44 45 J' ****** I 6KLC1UH lit CHfc.HU'A Lb 6 POLYMERS I LIVER Angloaarcoma Caues - (Review Date : I January 1986) UPX/ASL - LANCLOCASES,6 l \ | ( COUNTRY AND l REFERENCE i NO I BELGIUM 1 l 2 NAME OR INITIALS 3 DATfc OF RUTH 01 12.01.n i i 02 SR i i i i \ i i i i ( i i 29 09 40 4 l5 6 1 _______________ 7 COMPANY | FACTORY FUST VC UPOSURC DATE OF DIAGNOSIS 1 1 81 9 1 AGE AT \ | YEARS OF DIAGNOSIS | EXPOSURE TO 1 DIAGNOSIS L l I l 10 1 1 1 1 1 YEARS OF 1 DATE OF EXPOSUHE | DEATH 1 J 1 1 12 HISTOLOGICAL CONFIRMATION 1 13 | 1 1 ESTIMATED f EXPOSURE | LEVEL J 14 OCCUPATION i | I l 1 1 1 ,n OTHER CAREER HIGHLIGHTS 1 1 | | 16 OTHER COMMENTS Soivay Solvay t Jncpfi | 1 Jemeppe 00.07.58 20 00 62 00.05.7b 00.10.79 63 \ 1 1 1 1 \ i t t 1 1 * 1 i i i \ i l i i i i i i i i i i i i i 1 \ 39 ( 1 1 1 1 1 1 1 1 1 1 1 1 1 L________________ 10 1 1 17 1 1 t1 1 1 1 1 1 1 1 17 129.06.76 i 1 \ 1 i 1 1 1 i 1 1 1 1 1 1 1 1 i 1 1 \ ( ( i t i 1 t 1 t \ l 9 |23 LO 01 1 1 1 1 1 1 1 1 1 1 1 1 1 x_____ ._____0- Yea Yea High | Aiitoe leaner | 14 yrs 1956-I960 | exposed to|Polyworker 200 ppm |3 yra for 6 lira | per day | and | certainly | under | 500 Pin | In 6 to | 9a 1 | au(ot1avea| 1966-1972 | expoeed tu| 50-200 ppmi 8 lira per | day In 24.1 1 ( Autoclaveu| 1972-1974 | expoeed to| 50-200 ppm | ln auto- l c l ave ruoa| 1974-100 | (Driller In a |foundry 1(2 yra) | Farmer | { 1 5 yra) I Work In glee* |1ud. 6 cheat|c a 1 lndue try IHepatlc teat* {In Oct 1974 |were norm*1. |Ket 1 red | Feb 1975 |Hoepltallaed |May 1976 (Complete (Clinical and Icareer detal la (are given In a Ipaper ty IHublet at al | In Arcti. Ba Ig. IMed. Snc. , INyg. Med. (Trav. Mad. ILeg. (1977 pagee (601-622 PP* 1 1975- 50 | PP RETIRED 1 | 1 Feb 1975| 1 J 06.62-03. | Au t oc earie r | Fireman a luce | let aIgn July 63 01.67 |5 yra 5 mtfce | 10 7 1. (79: Thoracic -10.71 > (Operator (pain 07.79. 200 ppm |1 yra 9atha. |Hepat1c t ea t a 8h/day { laltered 10.79. 04.63-12. | | Poa11lve 66 < 200 \ (ei-liography Pl 1 1 1 1 i 1 1 ii- ______ _______ (11.79. llepa 11 ert oay 02.60. |{heaolherapy. | t ii t urma t 1 <mi Iglveii In |UilcJ 12 Row | 1464 liua Ur j____________________ fcOe SIoiivei . CMA 0 0 9 9 5 6 Page 2 DAY MUNIR - YEAR VJI'A/ AbL I.AfiU idlajlj CANADA Sheet I LIVER AnnXoaart-<>na Cat>es - (Review Date: I Jan 1981}) 1 J f 1 COUNTRY AHD REFERENCE NO CANADA * 1 21 J 1 HAH OR | INITIALS | 1 l 1 1 1 ------------------- n------------------)1 4 |5 6 6 J_ 1 DATE Of 1 IIRTH 1 COMPANY 1X X X 1 1 FIRST VC DATE Of AGE AT | PACTORY exposure DIAGNOSIS DIAGNOSIS 11 J__ 1 X 11 1 SHAUIHICAM X 9 10 1 1 XJ YEARS Of EXPOSURE TO DIAGNOSIS YEARS Of | DATE Of EXPOSURE | DEATH 12 HISTOLOGICAL CONFIRMATION I 1 1 14 1 15 l 1 ESTIMATED | EXPOSURE | OCCUPATION | LEVEL 1 1 ' GTHfcR CAREER HIGHLIGHTS 1 | 1 1 1 16 OTHER COMMENTS o 3: > o o 'C o cn si fll 1 1 1 02 03 04 05 X 06 07 1 06 09 1 1 1 IIS.12.J1 1 \1 J_ 11 (06.03.14 1 11 1l \X t\ |26.08.19 1 1i 11 11 1l 105.04.19 1 I1 11 \1 1 11 I07.05.IL 1 11 11 \X 1l 115.12.19 l 11 11 __L 11 |09.J1.19 l 11 11 \I 11 113.05.20 I 11 l1 1 ( 1 9 .0/ 71 i 1 J i 1 1944 L95S 41 1 J 1 1U2.09.55 Yea 1 1X X J 1 1941 1957 X 41 14 L4 121.12.57 Yea 1 1 1X X X 1 i 1 L94L 1962 42 21 20 |23.03.62 Yea 1 1 1X XX j. 1 1 L945 196 7 46 22 22 | 2L.01.66 Yea t J 1 1! 1 1 J944 1966 57 24 05 io5.o;.6d Yea 1 1 1 X 1i 1 1 1947 1971 51 24 23 | 10.04.71 Yea 1 * 1X 1 t 1946 1972 1 X 53 26 11 25 124.12.72 Yea 1 11 1 11 1 1961 197 3 53 1 12 1 05 112.06.7J Yea 1 11 1 1t 11 1 194 b 1974 51 1 2H 1 26 104.09.74 Yea 1 11 1 11 1 1X ^|>ei hy Dr DELORME in Ann.tlob d ' Anal uml e pnt ho I ng 1qne Pdils, I 9/M VnJ 71 No i pplU5~H4 clniiBb <hlb ceae had both a hepatone and ASi |Reactor |c L eane r |Operator |banker |pol/merlaat lon| l 1I |HaInt enance '(Operator lalllur Ight , |plpef11 ter IWorked (overt lae |Saoker 1 (Operator, |foreman 1 |Worked (overt lae |Non-*aoker t |Rear t or |cleaner 1 Operator, 11 or ecaatt, 1 we* e r cooling | uul t |Worked (ovettlaa (Saoker ! J Keac t 0r |cleaner |Reatt or |c leaner 1 (Water cooling IWorked |unl t |overc lae J Saoker | Ha i or enance , 1*111wrlght i 1 1 Worked lovertlae |Saoker 1 * |Reactor 1 c l eane r 1 Reat tor |t leaner | Pinnate up. | p1pet i 11 e r |ad 1 nt enance |Machine a6op (operator and tpoly mi 11 | Ma 1 nt e nance 1 taaeli 1 ne a hop IWorked |ovet tlae |Saoker 1 1 | 1n 1 25 pi ant yi a 1 bank c 1 1 1 | Uij 1 ked l overllae {banker J____________ I am 11 diietmn I y . fane 1 CANADA Sheet 2 COUNTRY AND REFERENCE NU NAME OR INITIALS DATE OF BIRTH 10 16.OS.IS LC 25.10.n 20.09.14 | Id CHEMICALS A POLYMERS DAY - MONTH - YEAR AM dates use UK syate* UPX/ASL - LAMC10CASES, 6 LIVER JaiglonarcoBS Cases - (Review Date; 1 Jan 19HR) f J5 FIRST VC EXPOSURE DATE OK DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OK DEATH H15T0 LOGICAl. CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 1953 Shawlnlgan Shawl tilgan 00.04.77 Heart or cleaner furnace op. Maintenance, packaging Letter liua Or Fernand Delorae, Pathologist Letter t roa Dr Fernand Delorae, Pathologist _L CMA 0 0 9 9 5 oo Page 4 CZECHOSLOVAKIA IC X CHEMICALS 6 POLYHhHS 1 LIVER Angloaartoaa Cases - ( Rev 1 ew Date : l Jail 88) UPX/ASL - LANG10CASES,9 1 11 COUNTRY AMD 2 NAME 1 1 J1 l Oft | ) date of REFERENCE INITIALS i BIRTH MO _L CZECHOSLOVAX IA 1 J 1 1 1 1 01 (28.06.20 1 1 1 1 J! I 02 (06.07.27 4 _________ COMPANY State Co State Co I5 | FACTORY I Novakr | Novaky b 78 FIRST VC EXPOSURE ________________ _________________ i DATE OF ( ACE AT DIAGNOSIS DIAGNOSIS ________________ _________________ 9 YEARS OF EXPOSURE TO DIAGNOSIS 01.0J.i7 24.12.71 | 1 1 4S ________________ _________________ 01.11.SO 27.lJ.6i. 17 16 14 1 L0 12 1 \ YEARS OF | EXPOSURE ( 1 _L DATE OF DEATH HISTOLOGICAL CONFIRMATION \ I 1 1 16 (24.l2.7i ( ( i i Yea ! _L I li (26.11.64 Yes n I 14 ; ti ESTIMATED l | EXPOSURE | OCCUPATION ( LEVEL | i1 1n OTHER CAREER HIGHLIGHTS (Aut oclave (Cleaner t |Au t or J ave 11ARC letter |uf 1-4-82 (giving details (froa Pro! (A David of |Cent re Ind |Hygiene and |Occ diseases. 1 ( | 1 ARC letter ol 1-4-82 gave laltered daces 11or thin cane. 11 have (accepted the |changea bluce |the datea cuae |fro. Prof (A David ot the (Centre ot |Industrial Jhygiene and (OccupatIonaL (Diseases. My Idatea cose lorlglnally (froa N10SH. J_____________ L 16 OTHER COMMENTS CMA 0 0 9 9 * i 1 ( u *0 PdK* 5 FRANCE Sheet I 1CJ CHEMICALS k POLYMERS | LIVER Angiosarcoma Cases - (Review Date; J Jan 88) WFX/ASL - LANG[OCASES ,10 1 J1 1 1 COUNTRY AMD \ REFERENCE | NO 1 FRANCE J 1 X 1 21 J t NAME OR | INITIALS | X X 1 1 2 _L DATE OF BIRTH 1 4 l5 6 _i i i COMPANY | X FACTORY FIRST VC EXPOSURE X J 1i 1i i 71 B 9 DATE OF L X | AGE AT X YEARS OF DIAGNOSIS X DIAGNOSIS EXPOSURE TO X DIAGNOSIS L I I 01 (H X 1 1 1 J X 02 | S1H 1 1 1 1 1 1 J 1 02 | NAV 1 l 1 1 1 J 1 04 | HOR 1 1 1 X 1 X J 1 05 | R 1 1 1 1 1 1 1 1 1 1 1 1 1 lJ 5.04.24 RP X 1 l X J _L 1 I02.0t-.ll PCUK X 1 1 1 1 1 J 1 106.OX.20 RF 1 X 1 1 1 1X 1 127.OX.27 PCUK 1 1 X 1 1 1 1 1 129.Ol.2B PCUK 1 1 X 1 X 1 1 1 l 1 X 1 1 X Roust- 00.01.46 18.02.67 X 42 2 X 11Ion 1 11 11 11 JX X 1 X Brlgnoud 06.07.59 12.01.75 L 1 J 62 X 16 11 11 Xt X1 1X 11 J X LX 1l 1 St Font 00.00.46 15.01.75 X 55 29 1X 11 X1 11 11 XX 1 |Brlgnoud J9.X0.49 16.OX.76 L l | 49 26 1X 11 11 11 1 X J 1 |Brlgnoud 1B.Oi.65 U.05.76 1 1 t X | 28 X 1 1 1 11 1 11 l l1 11 11 11 1J 1 t *i 1 (1 X 11X X 11 i 1 11 i i X1l 1 10 | 11 12 \ _L X YEARS OF | DATE OF HISTOLOGICAL EXPOSURE | DEATH CONFIRMATION 1 1 X 1 19 XX9.02.67 1 Yea 1 1 1 X1 X 12 |24.01.7S Yea 1 (NIOSH no ci u 1 J 1 X 1 1( X 29 129.06.75 Yea l 1 1 1 1 1 X 26 J04.01.76 Yea 1 X 1 X X 1 1 1 M 112.05.76 Yea l 1 1 1 1 J 1 1 1 12 1 14 ! 1 1 ESTIMATED 1 EXPOSURE | OCCUPATION 1 LEVEL 1 1 1 1 OTHER CAREER HIGHLIGHTS 1 | I 16 OTHER COMMENTS high High High High High |Autoclave Iworker and X c leane r X19 yra X X | I 1 |Ref. Ravler at Jal Arch. Ha X. |Prof. 1 30 a' 13 Nov 75 (p 171-177 |2 y ra on |Bunuaer 1 IU yra on | polymer- XlaatIdo | I [ a J1 an |orIgln 1 1 | | 1 i (Ref. (C bonne ton ci Xal "Nouvelle |preaae Jaedlcale" (5 Nov 1977 Xp 735 |Poly worker 110 yra aa |VCM productlonlRef. Hety et |16 yra |al Arch. Hal. (autoclave J Italian PON IProf, 37 n' Xc leaner X Shepherd, (6 June 77 (Compounding (Sawyer, Mason Ip 55J-555 1 2 yra 1 IHonoaer |production |worker 18 yra |PVC 11 1 It rat Ion |16 yra 1 1 1 | | 1 ( |Poly worker 111 yra |J)Thoracotomy 19t ti Feb 19 7b | r oat a 1 (anglosar* oas |Kef. P Loudeic | e t a I bra* l ne Idea huupltaux |10 Sept eabre 12)SclnlIgraphy 1 1 9/b 1 found A SI . | Pre v 1 uiid 1 y had | 2) tlaemu r l Itsge | hone J1rua ASL | aitg 1 ubsj i u |4}K1ght | A1 ao |Nepaltit omy |PX1J l howekJ el | |a 1 "La NooveIIe 1 J Pi eaae Ned Kale 1 (7th July 19/9 __________ |Page 2465 0 9 6 6 0 0 VWD NANCE Sheet l 1C L CHEMICALS A POLYMERS LIVER Angiosarcoma Caaen - (Review Date: 1 Jan 1988) UPX/ASL - LANCiOCASES.li COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF R1RTH first vc EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OE EXPOSURE TO DIAGNOSIS YEARS OE EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER I' OTHER CAREER | COMMENTS HIGHLIGHTS i ____________ I___________ \ 14.04.34 IrlgQowl 01.03.5* 12.08.76 1 07 1CIR I I I 1 1 1t 126.04.27 | 11 11 11 11 1J RP 01 .04.34 Solvay 11 l |St Auban | 01.07.50 | After 1\ 11 t death t HI0SM 11 1l \ 1 00.07.76 1L i 1 1 1 1 1 1 23.05.57 03.12.75 49 11.09.76 (NLOSH eaya 12.09.76) 1 1l 26 1 22 (02.07.76 L Yea 1 1 | (NI0SH no 1 l | commeot) I 11 1 L1 lJ 19 19 30.01.77 HlKh {1958-1960) JThla man had 2 yra |A0L prior to filtration (AS. Ann. de 10-11 yra I Mai. Prof. polywo*ker |July 477 and uorka |p 645 6 6. lab7 |AOL waa found |In 1971 five Iyra before | ASL I 11 | Plant fore- i1972-6 admln |Died of (man fn (aectlon In leaptIceemla |polymer- | St Auban (Smell liver |teat ton 1 |lee Ion found J1 lefter eutopey _J J j____________________ 6 yra packer 4 autoclave c Inr 14 yra autocIave worker Hied been (tunnel wurke |prevtouely 0a.L0.l4 I0.0l.4ti 26.04.76 63 o 3: > o o <1 'O 0- 25.12.77 Very High 1948-1966 Leaner Eapoaure 1966-1976 Polymerlea L ton operat o rt autocleaner, autoclave al at en&uce 10 yra In |Ope rated 4,76 aulphu r1c |for removal of acid factory, | tumour from atorekeeper 6 111ver and general |d 1 ed after aervlcea |aecood (aurglcal |ope rat Lon tor |bI Mo | brunch I a I 11lat uia |Paper by |Dr Ketf et al 11 n Art blvea de |Ha laden |Protean* <>nala |Vo 1 40 No 6 11979 pagea *741-). J---------------------- PK FRANCE Sheet 1 1C l CHUM CALS A POLYMERS LIVER Angloearcoma Cased - (Review Date: l Jan 1986) ! WPX/ASL - LAMCIOCASES, l 2 1 1 i 1 COUNTRY AND I REFERENCE l HO 1 1 1 France 1 1 21 1 1 NAHE OR | INITIALS l 1 1 1 1 3 DATE OP BIRTH O > o o *0 o Ch ro 10 |VP 124.05.19 11 11 11 11 \ 1 |L IIS.02.12 11 11 11 11 I1 11 11 11 11 11 1l 11 i1 11 \1 \\ \ 12 1 1 <16.06.14 11 1t 1 1 n\ 1 1 i |19.01.31 1 11 11 11 11 1l 11 11 l1 1 14 |MJ 1 |05-l>4~24 l1 11 11 11 1l j________ ,.t.......... . 1 4 |S 6 7| 6 1 9 COMPANY 1 1 | FACTORY 1 1 1 1 FIRST VC EXPOSURE DATE OP | ACE AT | YEARS OP DIAGNOSIS | DIAGNOSIS | EXPOSURE TO | DIAGNOSIS RP |Sr Pone 1 1 1 J 1 RP |St Pona 1 1 1 1 1 1 l 1 1 1 1 1 1 1 1 1 PCUK 1 |Brlgnoud 1 1 Solway 1 1 ITavaux 1 1 1 1 1 1 l l l l Chi lie 1 St Ftnle. (Limit- i l Feu net 1 V 1 RP> 1 1 1 _J 00.12.56 od.oi.4i 09.02.49 ll.09.6l 1943 1_________ 10.01.26 12.08.7B 00.OS.79 26.04.79 00.07.81 | T \ l | 56 66 6S 40 57 1 1 | 1 t i 21 3? 30 16 36 1' 1 10 J 1 YEARS 01 | EXPOSURE | 1 J 1 1 1 t DATE OF DEATH 1 1 | | 1 J 1 1 11 12 1 13 t J_________ J 11 HISTOLOGICAL | ESTIMATED 1 CONFIRMATION I EXPOSURE | | LEVEL 1 JJ 11 11 14 OCCUPATION 1 | 1 1 | 15 t OTHER CAREER HIGHLIGHTS it OTHtH COMMENTS 21 J10.01.78 | 11 11 11 11 31 _i un_._1_1_. Je J 1 11 11 11 11 11 11 11 1J 11 11 l1 11 I1 \1 11 l1 JJ 27 123.06.79 1 11 11 11 j____ j 13 122.08.79 | 11 11 1l 1l i1 11 1t t1 i1 11 36 (29.07.81 | 11 11 11 11 11 j________ 1 Yea Yea Yea Yes Yea |1 High Aut uclave 11(1 yra In 1 tcleaner |mechanical Died of pulmonary 1 1 1 t 1 High 1 1 1 1 |1941-1946 lengi neerlng (Induatry |1946-19S6 emboli am S day# after aurgery 1 |polymer1 | laatlon 1 Igeneral 1 |purpoae 1 | wti rAe r 1 11946-1972 1 | VCH 1 |a ynt hea l a 1 HHCl A 1 |Acetylene) 1 |Foreman 1 |(agent 1 |de matlrlae)| 1 11972 1 | ret 1 red 11 1j 1 High 1Monomer I JproductIon 1 (and polymer- I | laatIon J |operator j 1 |Autocleaner |2 yra aa cycle Clgarette 1 |? yra. Imechanlc. amoAer uutlJ 1 |Auto- |JO yra aa 1974. Ill all 1 loperat ur lenameller In of I 9 fi doc to 1 |9 yra. laanliary ware Oesophageal 1 | l.upotymem | manuf act u re varUe*. 1 1 4 yra Surgical 1l l liter vent loo 11 I1 25.05. 79 t rlght 11 iepa I et l oay ) | Veiy High |1943-1975 | 1975-1979 t 194 1 -197 5 |A 11 t ypea ul | an 1 lit enatn e 1 and | | obu OK | work l 1n(ermlll- |taa uutart ure | c-iit 1 y | A ad l nl e (id tit e | 19/5-1979 | 1 i) VCH Poly 1 | Hr in eta FRANCE Sheet A ICi CHEMICALS t HUl.YHb.KS LIVER AnRloearcoaa Caaea - ((tew lew hate: I Jan 196b) WPX/ASL - LANGlOCASES , 1) COUNTRY AND REFERENCE HO NAME OR initials DATE OF BIRTH France \ 1 i\ l1 1 1 IS IDEK 1 1 1 1 1 ! 103.01 37 | Chloe |St Fona 1 | Chlale J 1 | (formerly | 1 l ar) l 11 1 11 1 1 11 13.07.22 Ch toe Chlale (Foraerly BF) 17 22.02.21 Chloe Chlale (Formerly RF> A- FIRST VC EXFOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF YEARS OF EXPOSURE TO EXPOSURE DIAGNOSIS DATE OF DEATH HISTOLOGICAL CONFIRMATION EST1MATLD | EXPOSURE | OCCUPATION LEVEL j OTHER CAREER HIGHLIGHTS .OTHER COMMENTS l 1 | 07.07.5S 126.09.62 l \ 1 1 1 L______________ 1 J 1 1 1 I 17.10.41 05.01.61 45 17.06.46 1 J | 27 1 l 1 1 1 ! I l | 27 1 J 1 1 1 1 --- 1 JAllve 1 1 ( I 1 J- -- 1 1 1 1 J... 03.04.61 Yea 1 1 l 1 |Hlgh-20 yr 1 |Aotoclave |Mode rate |cleaner |J yr. 11955-19b2 1 (autoclave 4 l |operator 11962-1962 1 Ji. \ 1 J 4 | | i | | | HiRh-33 yra(Polyaerlaat- Hoderate- |lon Pruceis Low - 5 yrajMan I | Ha 1 lit e nance | Worker I (Healttt A | Safety Agent JL I High - | Au t oc1 awe Other aector* 23 yra J Cleaner ot St Fona |1946-1971 Fait ory 1971- 1976 ILeft (iepatectoay 11963 ( |J C Contaaaot |Letter of 15 10 1963 1 1 1 i Retired Jan 1979. J C Contaaaot Let tera of 5 JO 1963 and 25 7 64. Ret 1 red 01.01.79 J C Contaaaot Letter of 5 10 1963 16 14.07.42 Solway 09.09.63 21.03.64 3lgh-J2 y r a | An l i>c I av Low - 9 yrajCleaner J9.Cl3.tt4 HI Kill lepetectuay >5.05.6424.09.64 heaot (let apy nr lung- ct aa t aa(a >art I at ca1aa1 on. >6.64 - I ivci e< nr r em e . 0.64 - I ting. willnt Inn ot lie d 1 Dense 9 6 6 0 0 VW3 Page 4 FRANCE Sheet 5 [Cl CHEMICALS 6 POLYMERS | LIVER Angloaarcoaa Cases - (Review Dace: l Jan I960) WPX/ASL - LANC10CASE5.U 1 COUNTRY AND REFERENCE HO FRANCE 19 20 2J i 1t 11 11 2 3i 4 |Si6 7| 6| 9 JO 1 11 1 12 J _J i X L L X 11 1 1 (1 l1 NAME OR DATE OF ( FIRST VC DATE OF | AGE AT j YEARS OF YEARS OF 1 DATE OF | HISTOLOG1CAL | INITIALS BIRTH COMPANY \ FACTORY EXPOSURE DIAGNOSIS | DIAGNOSIS | EXPOSURE TO EXPOSURE | DEATH | CONKIKHATION | \ 1 1 DIAGNOSIS 11 1 XX J X LL X JL i 1i Ji ll ii Ji li HAZ IS.12.32 At oche* 1 | Br Igooud 07.04.59 1 26.10.64 | S2 * | 25 ii 25 |06.L1.65 J Yes 1 i 11 11 1 J1 11 _______X X 1 J 1 J1 XLL li 11 X JL 1 J1 i BR 102.03.23 Atoche* 1 Brlgnoud 19S1 27.12.6S | 63 | 34 22 |26.12.6S | Yes 1 01.10.40 set* Montlucon 03.06.06 13.06.26 0l.09.S8 OS.II.87 26.06.66 13 1 14 J IS 1 lb ESTIMATED EXPOSURE | OCCUPATION | LEVEL OTHER CAREER HIGHLIGHTS 1 1 | 1 1 OTHER COMMENTS High ti |Au turlave | loperator and| |cleaner | 1 JNyocardial | Infarct Ion JI960.Coronary (bypass I96J. (Letter fro* | Or Contaaaot 15.4.06 High i | Autoc lave i1 J In other parte 1Porc.l (operator audj if factory Iflbrosis fro* wince 1946 126.04,74. Th Jlllness waa Jdlagnosed aa (presuaably |work related [on 20,04.74. ILetter fro* | Dr CoiUtaaoi JOS.04.86 High Auttic leaner 4 years Maintenance worker J_______________ I )Hepatic teat (May 64 noraaJ. |Hepatic teat |Hay 66 showed |abnunaa 111 lea. ILetter fro* | Dr barrel | 16.07.66. High J9S0-7O l.ow 1970-64 12 years Autor Lave worker. J 4 years I it J_______________ I ILetter fro* |Or Conlaasot, | At ochea I2.J2.87 Control Kooi CMA 0 0 9 9 6 4 S 9 6 6 0 0 VWO Page GERMANY Sheet I COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OP BIRTH 00.00.31 00.00.30 12 00.00.30 ICl CHEHICALS A POLYMERS LIVER Angluaarcome Caae* - (Review Uate: Jen HUE) WPX/ASL - LANGIOCASES, l 5 15 PACTORY FIRST VC UPOSURE DATE OF DIAGNOSIS AGE AT | YEANS OF DIAGNOSIS | EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTLMATED EXPOSURE LEVEL OCCUPATION \ OTHER | OTHER CAREER | COMMENTS HIGHLIGHTS | ____________ I___________ I 01.10.56 19.09.6S Yea (N10SH) Polyworker 14.10.57 25.09.70 12 09.06.52 00.03.73 43 J3 26.11.74 Yes (NlOSH) 10.10.73 Yea (NIOSH) 25.11.74 Yea (NIOSH) Polywo rke r FI Ming peellclde aeroaol ca with VC _L J (Reporced under |non polymer|laetIon Iworkere In 1NIOSH I lac ut 131.3.77. iThla of courae Me atrlctly |correct. |However ( jwonder (whether thle |man had high leapoaure to IVCM In hie lean filling loperat Ion? J____________ 200-500 ppm Polywurker A J 95b waa but high temporary autocleane r during J yr autocleaner for ] yr autocleaner |Cllnlcat Idetalla In |paper by ICokel el ai IVlrchowa Arch |A Path I 976 |3/2 p 195-201 I I Page GERMANY Sheet 2 1` ICJ CHEMICALS A POLYMERS I LIVER Anglouarcoaa Cadet) - {Review Date: 1 Jan J9ttft) WPX/ASL - LANG IOCASKS, 16 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH (NIOSH given as Case 06) 00.00*36 I 06 4 1 (NIOSH gives| sa Case OS) | i 11 100.00.32 1 14 11 41 1 _L_ 7 FIRST VC tlFOSURE 02.04.60 DATE OF DIAGNOSIS 10.12.n AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OP EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION Yea (N[OSH) _L ESTIMATED | EXPOSURE 4 OCCUPATION LEVEL | I ) | BO CheaJe | aayu | "cheat ttt r y | Leburatur Lai | In the |Techno]logical ftteaearch | Departaent" 4(NIOSH says laaalstant | fact ory Ichealst (which aay be (wrong II rauslatIon) ,I OTHER | OTHER CAREER I COMMENTS ICHLIGHTS 1 ___________I___________ |Conflroed |Reported under |mm-poLyacr|laatlon |workers In lNIOSH 11st of 111.3.77 end 11.7ft. I don't Jttilnk this Is |a correct |cleaalflest ion |by NIOSH. Ths lam oay heve I been Involved 4 in VCM JpolyaerlsacIon (In pilot plant (nr In Min Iplent. 11 1 1 l 7 | 16.12.62 | 00.00.75 ( 43 11 1 1 1< 1 4 11 1 4 11 1 1 | 1 4 1 ! l 41 1 i) I 12 |09 01.7S { Yes | i 14 1 \ \I 1 4 11 4 ____ L_ -J.. _______ 1 ________________ 1 21 {NIOSH says L2) 1.11.75 11 |PVC - Menu- ( 1 | Ifacture | (Shift Leader| | | 11 4 iii |PVC Hanu|f act ure and (a I) work | Inc l ant ti le leaning Il2 yra 1(1954-66) JForenan Teel |l>ev ft yra M1967-1975) |Pulywuike r 6 0 0 VW3 CMA 0 0 9 9 6 7 Page GERMANY Sheet 1 12 | COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH COMPANY 00.00.14 10 (NIOSrt gives aa Case 1I) 00.00.16 11 (NiOSH gives aa Case 10) 00.00.29 1C1 CHEMICALS i POLYMERS LIVEN Ang1oaarcoaa Cades - (Review Date: J Jan J966) WPX/ASL - LANG 10CASES, I 7 FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEANS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 20.02.6L 16.06.76 4J 10.10.55 26.06.77 00.00.61 00.10.77 24.01.7fl 2fl.06.77 U7.10.77 Nigh peaka 12 yra po y * worker incl 172 autoc J ave v leaning Control rutin J yr High peaks 10 yra polyworker lack 172 autoc lave clesnlng High 1 yra flutot lave c1 erner J 9 yra filter operator PVC Kenut at-1 ure Autoclave worker for b yra 0/7H Coni lned Average expoa ure 11 y ra ISO p 1000 P Neat 1 yra 75 ppa. La yr av 15 pp Average empoaure I 9 yra 150 occ 1000 Last yr at /5 ppm. < letter ot 21.04.76 Page I3 GERMANY Sheet 4 1CI CHEMICALS k POLYMERS LIVER Angloearcoma Cane* - (Review Date 1 Jan 1 988) WPX/ASL - LANG10CASESJO 8 9 6 6 0 0 VWO to Ll 1 COUNTRY AND j REFERENCE | NO | GERMANY ! 1 | 21 1 KUC OR | INITIALS | 1 J 1 1 3 DATE OF BIRTH i 1 l l i ! 1 I i COMPANY !5 6 9 i i FIRST VC | DATE OF | ACE AT i FACTORY EXPOSURE | DIAGNOSIS | DIAGNOSIS i YEARS OF EXPOSURE TO DIAGNOSIS 1 J! _L I 11 i 11 10 i ii 1 12 YEARS OF | DATE OF | HISTOLOGICAL EXPOSURE i DEATH 1 CONFIRMATION 1) ( 1 1 1 1 1 i 14 | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 L 15 | 1 (NIOSH glveef this as | Case 11) | 1 1 1 L (6 | ( l 1 1 i i t t * i t i t t t JOQ.OO.U I 7 i 7 00.00.AO i oa.04.?a i si 18 ii ii i i 1i ii i i 1I X ii 11 i ij 11 X ii j j_ 1i _L Xl i i i _L i 1I X ii 1I 1 ii 1i 1 ii 1i J ii 1i \ ii 11 X ii 1\ 1 ii JI 1 ii 1\ 1x 1 1 ii it 1t \ ii tI 1 ii 1 1 ii 1i 1I 1 i ii ii tI 1 ii ii 1l i i 1\ 100.00.29 \ J. 1 J1 _L a 1 a l 19.10.SI 1 04.I0.7B I *4 25 1i 1 Xi 1i 1 11 1i 1i 1 1 11 11i 1i 1i 1 1 l1 J1I 1i 1 1 1j 1 _L _i. 1 1 100.00.21 i 4 1 4 10.OL.SS | 07.08.73 1 SS I 21 Ii 1 |(Lei bach | i 1\ l (suspected i * (\ 1 |ASL at | i 1i l (Fe b 19 7 S | 1 1i 1 |laparotomy)| 1 (i 1 1X1 1i 1 1X1 1i 1i 1i 1i 1 1 1 1 111 11 1 1 111 I11 1i 1i 1X 1X 1 1 1 1 1 11 1 1X 1 1X 1 1X 14 |19.05.78 X Yea ! 25 * | Not an |Angiosarcoma |In hla letter |of 21 12 31, |Hr Frledel |eald thie war |a "Plattenspl|thelkartinom | Der (Spelaerohre" ((a carcinoma (of the (oesophagus) |not attrlbuctable to VCM 4 |not recognlaed |aa an induet(rial dlaeaae i 121.10.78 1 Tea 1i 20 107.06.78 | Yes |ASL and | He pa t oc tUulac t Care I noma 11 t H | 1 ESTIMATED 1 EXPOSURE | OCCUPATION | LEVEL 1 t 1 11 11 11 11 11 11 11 11 ii ii ii ii ii ii ii 1t ii X1 ii it ii i| j| ti i| ii ij ii tX 7 (Autoclave | (cleaner and | | worker. | (Drier ( loperator. | |Later ahltt | | leader | High 1 1 |Auto*,lave (worker till JL9E4. | Leader and Imaeter 1 1 ( | | 1 | 1X I| 11 11 iJ 1t I| || || 11 J__________________ L 15 I OTHER CAREER HIGHLIGHTS ( 16 ( | OTHER X COMMENTS ( ( J r j |F V Beat (letter of |10th June (900 lencloalng data I from |Hr H P Fried*l |of 8C Chamia IF W Beat lletter of |30th June I960 |enclosing data | from (H P Frledel of 1 BG Chemle (wlthdrawing (this caaa | 1 1 * 1 I 1 1 1 |Angiosarcoma |c onf 1 need IU9/79. Some Idetell oi thl* |k alao caaea J91 13, IS. 16 |k J 7 gIven (n | NKW Repot t tui 1 1978 | Angiosarcoma jeonf l need, 11 ull detella |of 11Incaa |alnee March |1973 given J n | NRW Ned lii*p IK.p lor I47B. |Ulf ferent JdetaJ J* given 11 lb "VC JAaaoi1*ted JUJseaae' by |Lei bach and |Hat ateller I(I4HI> p71. 6 9 6 6 0 0 VW3 P*K* GERMANY Sheet 5 COUNTRY AND REFERENCE NO NAHE OR INITIALS DATE OF 11RTH GERMANY 11 < NIOSH give* an Case J S) 00.00.37 (0 oo.oo. n l9 00.00.25 20 00.00.15 00.00.13 00,00.2l ]C1 CHEMICALS t, POLYMERS LIVER AngtonarcoM aaee - (Review Date: i Jan I9B0) WPX/ASL - LAMU IOCASKS,(9 FIRST VC EXPOSURE DATE OF DIAGNOSIS 14.Oft.7ft 66.06.55 25.12.79 lft.10.54 00.06.79 14.02.61 00.04.60 0J,0(.62 00.09.79 pronounced i Uuli a) liver a yat uu > 2tl.UB.ftn ACE AT DIAGNOSIS 66 65 66 YEARS OF EXPOSURE TO DIAGNOSIS ~ir 25 YEARS OF EXPOSURE DATE OF DEATH HISTOLOGIC AT CONFIRMATION 20.06.7ft 25.12.79 16 22.02.ft0 Yea HetaaCaalng ASL 13 19.10.60 Yea Haeaanglo Endothelloaa of liver wltii Metaataaes 13 Yea Haeaanglo Endue he IJ oau ot liver wl tli ie t as t ribvb Yes let au t a a I ug ASL ESTlMATED EXPOSURE LEVEL OCCUPATION High Au t gl 1 a worker High Au t uclave Worker Autoclave Worker High Au toclave A>rker High Au t oclave Worker and worked In drying ahup IS OTHER I | CAREER | HIGHLIGHTS ( _____________L I I | Angloaercoae Icon!i ned. (Annual report (of the North |Rh Ine | Ue alpha 11 a (Medical |Inapectoretc |lor 197ft Ipagee 347-37/ (give* Cull Idetelle. Vinyl Ichlorlde Id laeaae Idlagnoaed 102-02-73. (Oeaophageel (varices. |Radiolog!celIf | confirmed aero (oateolyaia, (Dr Reach* (Letter of (11-04-62 to | Dr W G F Ada _L | Dr Reach* (letter ot | I 3-04-62 to |Or V G F Adaa i I_______ (Dr Bewche (letter ul |13-U4-H2 l | Dr W C FA High Autoclave Worker | Cliargehaml, |Dr Bcuclir | uutitiei|uent ly f letter ut Fureaan |3-04-fti t | ___________________| Dr W l F A Page GERMANY Sheet 6 ICi CHEMICALS A POLYMERS LIVER Angiosarcoma Cases ( Rev Date: l Jen 1986} WPX/ASL - LANC10CASES.20 COO NTH If AMO KEELHENCE NO GERMANY 2) NAME OH INITIALS DATE OF BIRTH 00.00.22 24 25 26 27 i i i i 28 i 1 l 1 1 1 1 1 1 1 1 1 1 00.00.28 00.00.23 00.00.22 too,oo. is i ti ii II 121.11.23 j 11 11 11 11 11 11 11 11 11 J1 11 1________ 1 00.00.17 00.00.30 FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS ms 26.03.79 S2 1969 1960 11.10.82 28.04.81 m3 14.06.76" 54 l- T~ J __L_ 1 1955 1 1 1. | 01.10.60 1 J 1 1 1 1 ( 1 1 1 1 1 11.08.85 1 i J | 1 i 1 1 1 1 1 1 1 1 1 1 J__ 55 61 I 951 07.01.80 00.04.65 YEARS OF EXPOSURE TO DIAGNOSIS JO YEARS OF EXPOSURE OATE OF DEATH 12 HISTO LOGICAL CONFIRM ATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 29.09.61 High Chemist ry <300 ppm) Worker 13 26.05.81 13 14.01.83 22 22 22.11.82 High Autoclave (100 pin) Cleaner High High PolycLave Worker and Autoc)ave Cleaner Polyworker Si---------- 1 1 1 18 j62.6i.4A j Yea JIJ j i1 High |Autoclave | fCleaner til if (1972 | 1 1\I 1 1 25 1 25 (25.06.85 | Yes 1 High |Process J 1 11 (worker 1947-| 1 |S4 <01.10.611! 1 111 1-31.03.64 | 1 111 |PVC product-! 1 111 |lon, | 1 111 lagltatur | 1 111 |area>. | 1 111 1 1 1 111 1 1 1 111 1 1 1 1t1 1 1 J il 19 15.02.64 __L .. High 1 Chen 1 at ry 1 worker 25.05.63 High Polywu rker Shill leader Allv Po ly worker Aut m iave c leaner Primary hepatocellsr circlnoM; proliferation of the fnuelode I cell* with sinusoidal ectael*. Frledel letter 23.12.66. Pruf Eder (Munich} Letter 22.08.83. Frledel letter 19.04.65. Prof Selmalr (Munich) Letter 22.06.83. Frledel letter 19.04.65 X (Chronic hepatitis, |angiomatosis, alnuaoldal (ectasia, Frledel letter 123.12.86. |Lei bach. iFrledel letter |19.04.65 J (Annual VCM screening (24.04.65: no complaliiL, jno abnormality detected. (1970 two-thlrda (gaatrectomy for ulcers. J(97l Coronary thrombosis J(963 femoral | lap 1 ant at 1 on |(964 Pulmonary embolism land pleuropneumonia. | La rulers letters J6.09.85 land 04.02.67. iHaemanglosarkoma. (Frledel letter 23.12.66. |Haenanglosarkoma. |Frledel letter 23.12.6b. |Haeaang J os a rturns. |hiledel Letter 23.12.6b. | Haemsng lusarkoma. |F rLedel letter 21.12.8b. 1 CMA 0 0 9 9 7 0 1**14 e ITALY Sheet 1C1 CHEMICALS 4 POLYMERS LEVER Angloaarcoma Caaea - {Review Date: J Jan J9E6) WPX/ ASL - LANCIOCASES.il COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF tlftTH ITALY 01 (On NLOSH supple mentary I let) 15.06.34 PANSAC Hire Venice FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH _1_ HISTOLOGICAL CONFIRMATION ESTIMATED 1 EXPOSURE { OCCUPATION LEVEL 1 _________ I__________ OTHER CAREER HIGHLIGHTS OTHER COMMENTS 00,00.65 19.04.71 16.04.71 |PVC bag lent ruder Primary tiauui nay have been pericardium. Not homogeneoua with other caaea. n.11.29 Mootedlaon Porto Marghera 00.00.57 13.12.72 Solvijr 43 15 22 20,07.37 AH1C 00.04.59 00.01.8J 43 21 27.12.72 10.07.75 30.03.EL 19.01.3? HI ra Venice (IO.lKJ.6 7 See Mall uni Med dl l-dvoro 6_5 p44S, 19 74. Further details In letter trow Dr Hoiitcsamj nt I ARC un April let 19g i. AI stij srd rid It <>ni and Kond1nel l d In A> l d Oncn 1 ug 11 a Vn I l 19gl l page a 15 - 49. |Polyworker I J__________ High 1AutocIeener (972-5 did (6 yra (1953- a variety ut |61) Autoclave Jobe (operator Including 112 yra (1961- PVC packing. JIIIL 12 yra - |1 yr - Never cleaned Very High (Monomer autoc J avea, -5 yra Medium tope rat or 1 120 yra - See paper hy CHIAPPINti et al Med Lavoro Non-amuker. Consumed |Autoclave VoJ 6 { 19112) little 4 yra Low (operator 6 pp 555-563 (other dot lee (In euepena- alcohol. Hu A0L. |J on po lymer- | leacIon. HedlumHJgh (Area Foreman (In a ane De pt | a lnee (975. _L Jhag extruder (1967-1975 | ConnerI'la) |Dept 1976- | 19H3 _________ S Pag Jlauiiga telex 2 Aug mi * 6 6 0 0 VWO Page 17 MALY Sheet 2 1CJ CHEMICALS A POLYHEKS | LIVfc.it AngLoearcoaa Canes - (Review Date: 1 Jan I98B) UPX/ASL - LANC LUCASES, 1 i COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH FIRST VC UFOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSES YEARS OF EXPOSURE DATE OF DEATH HISTOLOC ECA1 ESTIMATED CONFIRMATION EXPOSURE OCCUPATION LEVEL OTHER CAREER HIGHLIGHTS OTHER COMMENTS ITALY 06 HantedUoD Porto OU 10.60 06.I2.8S Harghera, Venice 11.02.86 High 1960-71 Med 1 uai 197I-7A Low 197S-8* PVC Manufacture 11 years as Autoclave cleaner 1960-71. |4 year* In Cont rol Room 1971-Bi Letters tro* Dr Chlozzlnlt 22.09.fl7 and II.Ol.flfl n 3: > o o 'O 'O SJ to 'age IAPAN id CHEMICALS 4. POLYMERS LIVER Angiosarcoma Gaaes - (Review bate: i Jan 1966) WPX/ASL - LAMGlOCASES,n 1 - 12 13 i 1 COUNTRY AND 1 REFERENCE | hahe oft | DATE Of INITIALS | BIRTH NO 1 JAPAN 01 1 [ l (Tamojl | Hurl (01*06.22 1 | f | l t I 1 1 1 \ 02 |SC i 102.06*14 I I | 1 1 1 in ITS 101.04*30 1 1 | 1 1 4 | 516 COMPANY 1 1 1 t FIRST VC | FACTORY | EXPOSURE 1! 1 \ Hltaul 1 1 IMagoy. | 00.04.53 Toatau 1 1 l 1 1 1 1 1 1 1 1 _____ _____ i 1 KanegafocM | Osaka | 00. H .56 Chemical 1 1 1 1 Hltaul 1 1 1N.goy. l 00.07.65 Toatau 1 1 1 1 _J________ 76 _________________1 _______________ X 9 DATE Or DIAGNOSIS AGE AT DIAGNOSIS YEARS or EXPOSURE TO DIAGNOSIS X a 24.10*75 a 53 a 22 10*06.76 X 37 17 26.06.65 54 1 l 1 X 20 10 YEARS Of EXPOSURE 13 13 5 '' 11 ______ DATE Of DEATH 11 12 1 1 j J_______________ J t1 HISTOLOGICAL | ESTIMATED t CONFIRMATION | EXPOSURE | 14 OCCUPATION 1 LEVEL 1 X J__________J l 24.10.75 11 |1 Yea |PVL Aaaoc ||1 yra auto- (aaya not Jc 1 ave | known. |t leaner |* Japan 11964 - |Times (assigned to (Indicated |d I f f erent (on 25.10.75| work since (exposures (had 111 (often at |health X 10.06.76 Yea (3000 ppm u Pi | to 1974 1 J__________ 1 11 (Not known |In polymer- 1 |l Bat ton work-t | 11 nclading t (autoclave Jcleaning 14.09.65 iJ 1 Yea \ High |S yeara | |Autoclave i |c leaner |J 11 X 1I 1,, 1 16 OTHER CAREER HIGHLIGHTS J ' OTHER | . COMMENTS (Japan Tlmea (25.IU.75 6 |Japaneae PVC |Aaaoc lettera (of 31.03.76 4 (30.11.67 (Japaneae PVC JAaaoclatIon llettera of (31*03.76 6 |30.11.67 (Letter from | Dr Nakamura, |Japanese PVC |Association J 30.11.67 * In hla letter of (at April 1962* Dr Honteaano of (ARC aaya Japaneae Hlnlatry of Labour give bate of dlagooala - 21-06-74 Age of dlagnoaia - 52 Yeara of exposure - 22 CMA 0 0 9 9 7 3 Pane 19 1C1 CHEMICALS 6 POLYMERS UIPX/ASL - LANGIOCASES , 2 4 NORWAY LIVER Angloearcoma Caaea (Review Date; Jen I9ttft> 1 I2 I 3I * 56 7 ft JIIL COUNTRY AND REFERENCE HO NAME OR i DATE OF FIRST VC DATE OF AGE AT INITIALS | BIRTH COMPANY FACTORY EXPOSURE DIAGNOSIS DIAGNOSIS 1 JL 1 ______________ ________________ _______________ NORWAY 9 10 LI 12 _L YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE __________________ 1 _______________ DATE OF DEATH HISTOLOGICAL CONFIRMATION I n 14 | 15 | ESTIMATED EXPOSURE OCCUPATION | LEVEL 1L OTHER CAREER HIGHLIGHTS | | J L 16 OTHER COMMENTS Ok AN 23.12.15 Norsk Heroye 00.03.SO 21.12.71 56 22 2k |04.0 72 | Ye. High Foreman 4 ttyd ro Au toe lave supervisor 1 ________ Confirmed by Or ThflsEvanaen of NH. At APHE Ht u of 9 June 197ft Hr P Raagnea stated that AH had been a member of a atart-up team. VCH 4 PVC were made In same but Idlng. The VCH was made from acetylene cma 009974 Page SWEDEN 20 LCI CHEMICALS 6 POLYMERS LIVER Anytosarcuaa Cases (Review Date: l Jan 1986) UPX/ASL - LANG IOCASKS,2 5 COUNTRY AND REFERENCE NO NAHE OR INITIALS DATE OF RUIN COMPANY JO FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED | EXPOSURE | OCCUPATION LEVEL | _______ !________ Id OTHER CAREER HICHLICHTS I I OTHER I COMMENTS I J___________ 1 05 l 1 1 J J 1 1 23.06.27 SundivtU IA.OS.il 20.10.70 Sundeval I 00.01.45 10.Ob.10 16.11.14 00.05.47 00.00.46 65 11 11 1 1 1 1| 12.01. 19 | Keats nord ISundsvsNJ l J.05.64 | 22.1 1,80 i bl 16 tl l1 l 1 1 11 11 1 1 * 11 11 1 l l J1 11 1 1 * 11 11 1 1 l J1 11 1 1 ! 2/ 21 19.03.76 12.05.77 l 11 l lb 122.1 i.ao j \ 1i 1 1i 1 1i 11 1 11 1l -J_______ Yes High J Holywurker _L | VCH |production I I I t Nigh High |Polyworker X |1946-1956 I polyaie rJ t sat Ion (worker ( 12 lyre) 6 1958|1977 foreman 1(19 yrs) I I ( 1 | High - | b Years | Low - l |U Years 1 1 f 1 J 1964-19/0 tcenirlfuge luperator 119/0-1980 |drler joperdtor l | | l | | J |Mr SJoelln'a |Ietter of | 28 March 19 78 Iconflras RE Jwaa a aonoaer (worker who waa Iheavlly (expoaed, I probably even Jaore ao than Ja aorul Ireaccor |cleaner J_______________ |In first 12 lyre of |eaployaent had Jbeen heavily lexposed. In |J974, liver labnoraal Ity land necrosla |d lag nosed. (Data contfraed |In Dr D Ryren |letter 16.8.fi Ito CEF1C 1 lLetler of | 2nd Nov 1 98 1 lltoa |br bavtd Byren 1 ______________t_____________________ * Eit his letter ut 1st April 1982. Mr Mnntesauu ol IAKC ssys In Sweden's Nations! UodrJ of US Hew 11 h gives 20-02-70 ss date of diagnosis for Case ill sjiJ 15-05-72 fur Case 02. CMA 0 0 9 9 7 5 Page UK 21 ICI CHEMICALS 6 POLYMERS ^ LIVE. Anglo..rcoaa C..e. - {Kevte. Date: I Jan L9HB) WPX/ASL - LAMCIOCASES ,2b SheetI i ii 1 13 i 1 COUNTRY AND | 1 1 NAME Oft | DATE OP REFEREHCE | INITIALS | BIRTH NO 1 1i \ 1 UK k i 1 1 4 COMPANY i |i 6 1I 7| aI 9 1 ko 1 M 1 17 i 11 1 14 1 1 1 1 | FACTORY X FIRST VC DATE OF L I \ ACE AT I I k YEARS OF EXPOSURE DIAGNOSIS | DIAGNOSIS l EXPOSURE TO 1 _L 1 1 1 YEARS OF | DATE OF k HISTOLOGICAL ESTIMATED t I EXPOSURE k DEATH | CONFIRMATION EXP0SURE | OCCUPATION | ij 1 k DtAGNUS IS 1 LEVEL | Li XJ i 1i i il 1 i 1I 1 1 i IS OTHER CAREER HIGHLIGHTS 1 J 1 | | 1 \ J 1 16 OTHER COMIEHTS 01 | UJ k 1 \ \ i \ \ i k 02 1 1 1 1 03 1 bjw l l 1 1 04 | JSR 1 1 1 1 l 1 1 1 l 1 1 \ \ n k l 3 > 1 1 o o 'O 'O M 0- 1 1 1 1 1 1 |20.04.01 ICI 1 1 I 1 1 1 1 \i i l 1 \ \ 102.06.37 BP 1 1 1 1 | 23.06.20 ICI 1 1 l l 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 k l l |HR XLhouaei 04.04.44 01.12.72 | 1 (Foa t | 1 Collier | 1 paper aayaf 1 21.12.72) 1 1k 1 JL 1\ 1 l 1 1 1 | Barry X 00.02.66 00.12.74 I i \ L I | 11 11 1 11 |Hlllhouae| 26.04.S4 00.06.79 1 1 | 11 1k 11 11 1k 1t 1t k1 1l kk kk 1k 1i ki ii ii ii ii ii ii k ii ii 71 37 59 1 28 22 |01.12,72 | Yea SUO ppa |1944-7 VCM tLee and Harry 1 |(Fox 6 k1947-B Drier| |Lancet i |Collier kI948-6L 129-06074 1 |paper l Au t u r L a v e Ipagea 1116-6 J laaya \ |21.12*72>1 i1 1J 11 loperator |1961-66 |Drier i k 1 k k l i 11 I fDubloua 11 1 ffabrlcatIon 11 Li \ i |ceae I 1 1 09 1 1.5 |24.12.74 | Yea Hltlh t [Autoclave 1 |Eapoeure 1k |cleaner lllalted to 1 1k k 12.66 - 9.69 1 | 25 11 1 16 112.10.79 k Yea 1k k Medltai- 154-S |Pre-war f Lah J 1 k k1 k1 k1 11 11 1k 1k high 1Baggtog |Plant |S5-6 IDrler Plant I56-S6 | Autoc Lave {worker |56-6J |packer j1919-45 a ray |vehicle laalnienence 1 li<s-51 I flah packe r k j i i t k 1 1 1i |Chargehand 1 1i 1i IDrler |Plane 1 k 1i k 1i 161-72 | Fu read ii k i k 1i |C 2/1 Plant k k 1i *1 k 1i l i 1i ki i 1i k1 i 1i i 1I 1 * i i1 i i1 i1 k i i j______________ ______ 11 ij J_________________ J___________________ X_ CMA 0 0 9 9 7 7 P*K UK Sheet 2 1 COUNTRY AND REFERENCE HD UK 05 NAME Oft INITIALS DATE OF BIRTH 30.03.14 06 sr 1931 TCM.il> BP 08.0S.26 terry terry terry terry [Cl CHEMICALS 4 POLYMERS LIVER Angloearcuaa Caaea - (Review Date: l Jan 196ft) UPX/ASL - LANG IOCASES,2 1 FIRST VC EXPOSURE DATE OF DIAGNOSIS 08.01.SI 00.10.79 1962 09.01.80 1961 00.00.00 Tl.fi4.10 2J.ll.Al ACE AT DIAGNOSIS 48/9 60 "5r YEARS OF EXPOSURE TO DIAGNOSIS 28 18 TT 3l 10 YEARS OF EXPOSURE DATE OF DEATH 12 09.01.80 sTl 11.06.BO 1Z~ 25.12.61 13 IS HISTOLOCICAL CONFIRMATION ESTUUfEb EXPOSURE ____LEVEL | OCCUPATION J________________ I 11951-32 |PolycIeaner 11952-55 | Latex |1955-60 |Polyfloor J1960-64 I Pol Y [Chargehand |1964-ro | Charging luperatur 11970-72 I Drier loperatur _L U yr. |Poly Floor |Operator |5 yra (Greaaer on 1 Poly Floor |Polycleaner 1 1963-5 (Recovery 11965-197 I 1950-1958 500 pp* 1968-1974 200 pfa 1 I 11950-5J | Aut oclave [operator 11951-1957 IChargeaan lautoelave [butIdlng 11957-1974 |Shi ft |auperv1aor |aut ocI a ve |bulIdlng |Never | r 1 edfieJ |aui01Jdvea [but |stiperv 1 sor' a 11oh ental led | e lit e r t ilg |iutuiiaveb |t0 loapect 11 hea i 1 OTHER CAREER HIGHLIGHTS 1936-1946 lotor Mechanic 1948-1950 Operator on Acetylene Product Ion Plant 16 OTHIR CCMMUTR Page UK. Sheet__ 1 ] COUNTRY AND REFERENCE NO UK 09 13I Jl NAME OR DATE OP INITIALS BIRTH COMPANY 07.05.25 GJT 04.04.47 >IUT VC FACTORY tarry 15.02.50 27.04.66 ICl CHfcHiCALS 4 POLYMERS WPX/ASL - LANGIOCASKS,2b LIVER Angloaarcoma Caseti - (Review Date: l Jan (9b8) DATE OP DIAGNOSIS 02.03.85 I AGE AT DIAGNOSIS YEARS OP EXPOSURE TO DIAGNOSIS 33 18 YEARS OF EXPOSURE 4.2 DATE OP DEATH 16.05.84 n _L HISTOLOGICAL J ESTIMATED | CONFIRMATION | EXPOSURE ( OCCUPATION ___________________ | LEVEL |________________ TT 16 OTHERTOTHER CAREER | COMMENTS HIGHLIGHTS I -_______________ |Polyworker 2 yeara on J | Acrylonitrile | Rea In Plant. | Alao prior to 1 1950. 4 yeara| RAF | maintenance. | 3 yeara motor 1 car paint whop.| 2 yeara In | I Graving Dock. | i (High - Jl i iPol yc leaner ______________L j Heavy good* |information leont Its ( 500| I 966-67 . vehicle drlver|glven In I ppm). Low-(Spray-dr ter unt11 final |Letter |16 month* I (5U ppm). | Medium - (bagger 19b?- lllnea. (66. 1 Slow-down 118.06.84 fro | Dr 0 H S |U11llama | 2 1 month* latripper | (200 pi> (operator \ {1968-70. 08.05.26 tarry 19.12.65 02.06.85 16.09,57 01.06.85 _L I 19 U2.06.65 High |polycleaner (Letter of 1965 -69 |1965-68. (04.06.85 Med 69-79 |Service I Dr Paul Smith Low 79-82 (operator land letter of 168-69. (04.06.65 | Poly |l)r 0 M D Ev ana |0perator (Oesophageal (69-79. |haemorrhage | Leading Hand |due to 179-82. (ueaophageal 1 (varicea due lo I (Angloaarcuma (of liver J_______________ J Low I957-59|Spare man. (High 59-74 baggl | l.ow 7 4-8 5 |1 lour (1957-59. | Auliu lave | Ope c a 1 <>{ | 1959-85 | L 11 e r | 2b.06.8 5 i lie > Lee j________ CMA 0 0 9 9 7 8 24 UK Sheet 4 COUNTRY ANU REFERENCE NO NAME OR INITIALS DATE OF BIRTH l1 1 i1 1 UK |MJ 102.01.48 |8P n1 1 1 11 1 11 t 11 t 11 1 I1 1 11 1 1 __ 1 J IS.06.42 1C I CHEMICALS 6 POLYMERS LIVER Anglos arcona Case a - (Review bate : l January 1988) WPX/ASL2 - LAMCIOCASKS,8 T 1 1 | terry 1 1 1 \ 1 1 1 <_____ terry 12 FIRST VC El POSURE YEARS OF DATE OF ACE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH HISTO LOGICAL CONFIRM AT I ON ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 1 \1 1 1 1968 11 1 Jan 86 1 11i 11 1 1J l 11 \ 11 1 1i1 111 1 _J ! 02.07.66 27.08.87 3/ ...J 11 I 1 18 1 3 11 102.06 86 j Yes I1 I 11 1 11 i 11 1 11 1 11 1 11 1 L_ -J_____ t 11 1 I 11 1 High |Polycleaner 1 |Moved to 1 |Regained well, working 1 |1968-69 |Aery 1 on!(rlie |*ctlvely, until Jan 1986 1 Low ICentral 1 Plant unt11 | 1 | Depot llefc IP 1983. | 1 |1969-70 |High Poly floor |Manager of | | 1C 4 SS Ltd at | l1970-1971 (Cardiff AlrpoTLI 11 11983-86 | t --11 10 Month* Polycleaner High 1966-67 10 year* Poly floor count ant worker at tin Hedlw between bu t on 1968-1982 Infer- 1ttent Job* Letter* Iron Dr DHD Evans, Pathologist, Penarth, Wale* amt Dr DMJ Ullliana, IP, terry 009979 o 3: > i i i t t j______________ i CHA 0 0 9 9 8 0 Fftge 26 USA Sheet 2 JCI CHKHiCALS 6 HULYHERS UK syBtea of datea WPX/ASL_2 - LANG10CASES,i | LIVfc.it Angloaarcoaa Ceaes - (Review Date: I Jan 1980) DAY - MONTH - YEAH n 3 > o o *0 'O GO COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH FIRST VC EXPOSURE OATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOCI CAL CONFIRMATION ESTIMATED | EXPOSURE | OCCUPATION LEVEL i 1 OTHER CAREER HIGHLIGHTS OTHER COMMENTS Raymond Getc ke pt age r? 00.11.31 Louievilla 28*05.45 M.03.75 2000 pj I a|Ref I ha (wrong figure (re flrat |exposure. |Loulavllie | Tl men |29.10.74, (12.3.75, (10.3.76 i 10 i \ (16.08.13 Goodyear (Niagara L2.06.51 1 00.05.68 ( 55 k1 17 1 17 k 10.05.68 | Yea i i 11 i _______________ !__________________ \1 i 1 11 127.05.09 Goodyear (Niagara 14.10.46 00.03.70 | 61 2) ( 23 116.03.70 | Yea i1 \1 1 12 | Francis A (I7.kl.18 Fireatooe IPottetown 13,07.49 02.05.69 | 50 11 11 20 1 19 (02.05.69 ( Yea | lactMD k | Pa 1 1( 1k t 11 1k 1 1k 1 ik 1 Ii 1 ki 1k tk 1 ii \ ji l l1 L -JL_ 13 Richard Edward Clendenln S Char le 11,12.42 nt on 00.05*74 52 07.04.74 1I 1i i i \ |Ref l 1I k1 t L I k1 1 (Ref 1 11 I 1 High IU yrt|ll) yra aa 1 | Ut 11 ley 6 i (Ref 1 + letter 1 | react or op. (Servlie op. |of 26 April 1 1(not cleaner|Bagger (1976 frua 1 (- aeparate (Dryer op. J Rueaell A Park ( |crew cLeanedlSt ripping op. (to J T Seawell k |autockavea) |J yra prior (of MCA i| i1 leervtce In (tyre plant t 1 1 2000 j>fm ii J_______________ \ iCharleaton |Dal 1y Hall J2I.7.75 j________________ i |Never dlag(noaed aa ang(laaarcuaa of (Liver, [ntora|atI on gIveu 1o | L elrer 22 Hay |1984 true j J A baJg. | Art ........ am , (ASL - No e v1 (driu nt VCM (expoautc. J________________________ Page 27 USA Sheet J 1C1 CULMlCALS A POLYMERS LIVER Angiosarcoma Cases - (Review Date: J Jan 1968) UK System ot dateb DAY - MONTH - YEAR WPX/AS L_2 - LANC10CASES,2 COUNTRY AND REPERENCE NO MANE OR INITIALS DATE OP RIRTU James Howard 04.11.27 J 7 Peerenboom Chari le Arthur 22.04.26 VIrglI 00.00.IS QtrUtUn FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS Lou lavilla 08.OS.SO Louis ville 15.09.54 00.00.7S S Charleaton AGE AT DIAGNOSIS 46 YEARS OP EXPOSURE TO DIAGNOSIS 32 YEARS OP EXPOSURE DATE OP DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER | OTHER CAREER t CONHEHTS HIGHLIGHTS | _________ !________ I 27.03.6S 02.11.75 06.04.76 1951-4 VCM polymerI Hat Ion Yea on H. 10.74 bat no post-mortem 16.10.80 _L L1 yrs Navy autocleaner 8 yrs on Lstol Tyre pleatIclser 4 Carboaet operat Ion _L Store 2000 ppm From 1954 1 | Table 4 In onward* In (Wagoner Army and oilier (Test tmony to service. |US Senate 4 6-50 Army |Cunfirmed In |M K Johnson 111 r 07.06.78 |Or K N John*on lletter of (24.2.81 conIflrmed death |6 years after |dlagnoala_______ 1 |Coni Irmed In |M N Johnson |ltr 07.08.78 (Also Rolling |Stone mag. |15.OJ.76 I J___________________ J JWl 1 Mams port | Sun Gaze t c e | 2 l June 1975 (Charleston (Dal Ly Mall |2J .7.75 31.08.17 Goodyear Nlagara Cheat e r Hinkle 30.01.76 Early 77 30.01.76 INJOSH letter lot 25.1U.79 J_________________ I |28 yis with |UCl at SC |Ket1 red |News reiesse (23.2.77 j____________ CMfy 009982 Page USA Sheets 1CI CHEMICALS 4 POLYMERS LIVER Angiouarcuaa Case* - (Review Date: l Jen 1988) UK aytitea of dateu PAY - MONTH - YEAR WpX/ASL_2 - LAMCIOCASKS,) COUNTAY AND REFERENCE NO USA NAME OR INITIALS DATE OP BIRTH 02.10.23 00.00.23 Greet Aaerlcen Steal ce 1 Coapeny li Cherlee I7.0i.17 UCC Edwerd Moore (25) FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS Louievilla II.07.A? 00.01.76 52 PI tchburg 06.09.38 Haas. 06.04.73 $ Charleeton w 17.OS.77 SO 60 treed In K Karelnskl let YEARS OF EXPOSURE TO DIAGNOSIS IS YEARS OF EXPOSURE DATE OF DEATH 28 04.12.76 IT 06.04J3 HISTOLOGICAL CONFIRMATION lt ESTIMATED EXPOSURE LEVEL J____ I OCCUPATION I 1 OTHER CAREER HIGHLIGHTS ,1 j j. | OTHER COMMENTS -------------------1________________L I I (Loulevllie |Tl*e* 26.1.76 (eld he wee I the 10th AS |v let la et (Belle Lene of (whoa 8 had Idled by J26.I.76 |In hie letter |of I6.09.8J | Dr M N Johneon (confira* tble |le the Jceee deecrlbad |by Deanaher (Teaburro 6 Yea 11n Feb J 980 I Am J Medicine |Vol 70 p280 I 1 J- 38 24T 27.05.7) Oiolenglo- ledlua to 1941-65 non- 11917-39 wea IN K Wheeler (NIOSH eercoaa high f or eolvent |off end on {letter of beye 26) (ft Real nek I 24 yre vinyl reeln 11ebou re r |18.6.77 to 2672/79) unit and 11939-41 aey |J Stafford dleperelon lhave been lg1vee detail* vinyl reelne (eapoeed ea |Roee Kealnekl unit flret l reactor (letter of at* fitter |cLeaner (26/2/79 nelper, the ) J 94 3 beciM |R Real nek 1 elilf r | shlM fitter |(S Nov 1980) utility nan J1946 bera.e (euggeeta that |ehlft utility | NIOSH wlH lean (retain un 126.04. | r eg later bIiuc leepJoyaent wat 11 hi e tie up I | teraUieted (aey be aaaucl- fated with ASL. ( (R N Mieeler | J et t er of 120/2/79 and |Ruee Real nek 1 |Ietlere ut (26/2/79 and (5/11/80_________ CMA 0 0 9 9 8 3 Page 29 USA Shet_S ICl CHEMICALS A POLYMERS LIVER Angioearcoaa Cases - (Review Date: l Jan 1988) UK aya tea of date* DAY - MONTH - YEAR UPX/ASL_2 - LANCIOCASKS , 4 1 |2 13 COUNTRY AND | REFERENCE | NO USA j 1 KAHE OR | DATE or INITIALS | BIRTH i i 'T i A 1516 JL 1 1 FIRST VC COW ANY | FACTORY | EXPOSURE 7 ....... DATE OF DIAGNOSIS JL it i 2b IJohn Berry 107,07.23 arc 1 1i 1 1 1 1 1 1 I 1 1 1 1 L Louta(villa i i 1 1 1 1 1 1 i 1 1 1 | 03.10.47 | 00.00.77 (up to 2 i i year* i after 1 i death) 1 1 1 1 1 i 1 1 1 j 27 |J L -L 11 1.05.16 IfCC |Forrest ii X |S Charle-I 01.07.41 i 30.11.78 | item 1 1 i 1 1 I J 28 1 1 j 29 1 1 1 i 30 | WK 1 1 1 1 1 1 1 31 1 1 1 1 1 1 1 1 l 1 1 1 i l X 111.04.17 1 LTCC 1 III.10.07 UCC 1 (22.07.22 Tenneco 1 Chmicats 1 X 108.11.23 UCC , 1t 11 11 11 11 1 (S Charte-I 00.08.44 t aton { 03.11.78 ii X 1S Charle-I 00.05.42 00.03.80 | aton | ii ii X | Fleal ngt on U.61.M 30.12.80 11 11 11 11 1\ t1 ii | S Ctiarle-| 12.OS.46 | stun | 01.08.81 11 t1 J1 11 11 11 (l 11 1l 11 11 11 8 9 1 10 1 1 1 ACE AT YEARS OF * | YEARS OF | DATE OF | DIAGNOSIS EXPOSURE TO | EXPOSURE | DEATH | i DIAGNOSIS j i 52 (death) 28 1 18 I 11.02.75 | (death) X 62 3J X 61 34 X 72 38 1 58 1 20 |2S.11.78 KNIOSH |aaya 27 land C (Dally Halil 125) i 1 1 33 lOJ.l 1.78 1 i 1 16 101.03.80 | i 1 li 130.12.80 j ! 57 1 1 1 1 1 1 J 1 1 * 1 35 1 13 102.04.82 1 ,: I1 I 12 1 l) ( 14 1 1 15 1 16 1 HISTOLOGICAL | ESTIMATED 1 1 i CONFIRMATION 1 EXPOSURE | OCCUPATION I 1 LEVEL | 1 )1 OTHER CAREER HIGHLIGHTS ( |, 1 1 OTHER COMMENTS Yea JExposed In |Various jobs! |soae degree!In PVC | (to 22 |plant a froe | (cheat cals |cold ruoa to| (but eafn I paste 1 (exposure | recovery tu | |waa to VCN . |PVC chargingl 1 JR Kaalnakl lletter of 126/2/79 and (Prof. Tiabattu lletter of |4/1/74 J |probably loperutor to | | |hi*h Ipaate | | (charging. | | ) 111 August 1 t1965. | I | Jleralnated | | leaployaent J | Yea |Jan 1966 | I 1 high lOperator to |Exposure In |R N UheeJer I 10.10.76 |bulk and Jltr of 4 Jau | Idieperalon PVC|I9?9 sod | laanufacture |Chart eat on J1 |Pally Hail || |30.11.78 and 11 |R Kaalnakl Yea 11 || 126/2/79 |R Kaalnakl | letter of Yea ii 11 14/4/74 |R Kaalnakl 11 JLettera of 1 |19th June 1980 Yea ii |6 - Unknown Maintenance 14 5th Nov 1980 | |9 - Minimal |Mechanic l |6 yra l (Elsewhere I 111 yra | J&oller houaet (Operator (4 ym | 1 1 1 j Yea IHluh (But (Chemical | Froa 1959 to |Dr Dacey loot da high |Operator In |J976 Allphatl 'lletter |as> reactor I charge | Cheat cal a | lb.10.81 and |c leaner Ireactnr (operator and |K H Wheeler |woold | |froa July 19/6tLetlei of Jexper li-in e) 1 J t o dat e 19.11.81. lUurkcd t*b 1 1 rlhl)U( V r 11 riua | j | |Foreman (AM ptial 14 Cheat a 1 (Also Dr Dacey | 1 el t er ot |D/ .01.11 l i e |June 1S4I I |Operal <m |da(e ot death. 11 ii H<i y 1 | | | d 11(1 lid y | | | 1 k d V L* J 1 l (. 1--1 *- 1 1 CMA 0 0 9 9 8 4 Page USA Sheet 6 10 Itl CULM I CALS i POLYMERS LIVER AngLouarroma Cave a - (Review Date: I Jan 1988) UK ayatem of date* DAY - MONTH - YEAR UPX/ASL_2 - LANG lOtASKS , 5 COUNTRY AND REFERENCE NO NAME OR INITIALS DATE OF BIRTH C W Cl rou* 22-02-08 FACTORY FIRST VC EXPOSURE Spring!laid IS-IQ-5I H date of DIAGNOSIS 00-07-79 ACE AT DIAGNOSIS 7k YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE 14 (in eve autoclave area) DATE OF DEATH HISTOLOGICAL CONFIRMATION _L I ESTIMATED | EXPOSURE 1 OCCUPATION LEVEL | _______________ I________________ T ii OTHER CAREER HIGHLIGHTS An autopay warn done and immediate cAuae of death given aa *Afiglu<i. . .wa The death |1940-1951 certificate!Various Job* gave |ln polymer Mr Clrou*1 (manufacture usual |BUTVAR occupat1 on |LUSTREX as "kettLe|1951 * I9b4 operator IVarloue Juba In |1n and Mcheaica1 Ja round PVC 1nduatry" lautoclavee ( 1964-1971 IVarloua LclerlcaL (Jobe In PVC |pulymerlaatIon (facility/ 1 Ret I red OTHER COMMENTS I | Information (given In (letter of 24 |February 1982 |from Dr |Halter C (Rsrnea of (Moneanto iSprlngfkeld to |0r A Munn of |Monaanto |Europe. ( 1 I k US 33 US 34 i i1 |S Ferguson108-10-27 ( RFC | Jnr | | ( ( ii 1 i1 i k |Mr By rim ii 11 (29-01-14 | RFC I1 1 1 (Loulavllle 09-09-54 ( 11-05-82 k 54 26 11 1 k it 1 k ii i l i 11 1 l i ii j i i 11 1 l (Loulavllle 1955 | 03-11-82 l 46 27 11 1 26 |Alive | Yea 11 11 11 11 ii 1k ID (04.08*83 (Yea 09-03-12 S Charle ston Tlie General A* ht ab Tire and Ula Rub be r Co 27 11 1 | (Multiple | i not.. * | | L nc 1 udlng ( 1 (Prof Tamburro (letter of |I2 Aug 1962 t 1 iPoly 1 | (Operator + | | |Polyr Leaner.( |Dr H N Juhnaon |k et ter of (26 Feb 198). 11 1 1 |PuJy 11965 Lett BFC (Dr H N Juhuauu (Operator + to become a 11 et ter of |Aut oclave Clergyman. 11 Nov 1982. |Cleaner 128 Feb 198) |1955-65. (and 9 Aug I J1984. j________________ High f J 944 t 1951. Medium fro 1955 956 J 11956-56 J_____________ 1 |Ur Dacey | J eiter ut 15 Sept 1981. I j__________________ I | R W Uun (1abuurer I 1956-57 | pr ud lie I per JietIer o |J 2 Sept Jspulted I 1957-70 |medlcaI (opera! or |1970-75 |e lett ill Ian | (975-preuen( (Hay I 98 J |Teat i iih (Hay (981 CMA 0 0 9 9 8 5 Fnge 11 ICl CHEMICALS 6 POLYMERS WPX/ASL2 - LAND LUCASES ,6 USA She*; t 7 LIVER Angloaarcoaa Caaea - (Review Date: 1 January I960) UK ayatea ut date* DAY - MOUTH - YEAR 21 L1 l1 J 3| 1i A | 5 it 1 |7 8 19 1 l 10 k 11 J J11 1 ii COUNTRY AND (NAME OK | DATE OF) i | jJ i1 tFIRST VC | DATE OF ACE AT * *k lYEARS OF 1 l |EXPOSURE | YEARS OF| DATE OF REFERENCE |INITIALS | BIRTH | COMPANY j FACTORY |EXPOSURE lOlACNOSISt 01ACN0S[SI TO J EMPOSUREk DEATH NO 1 i i i i1 |DIAGNOSIS] 1 i ii i i 1 USA 37 1 I Hr J ii 129.08.291 BFG |i Loula- i 1 1951 i 106.00.04 1 <54 31 I 22 106.00.64 |Payton 1 1 1 1 1 1 1 k |vlll I 1 1 i t 1 1 1 1 1 1 1 1k 1 11 1 111 1 11 1 111 1 11 1 1 k |J 3 JUB 1 1 11 1I J11 ii I28.O0.22J Air |j Product* ii 1 1 i |Calvart tClcy i 11 k1 k k Ji 100.02.63 119.OJ.04 kk 1k k t i k |61 20 k 20 |20.L0.83 l k l 11 I 11 1 11 l11 1 kk 1 1i 1 k i 1 11 1 11 1 11 1k1 1 k 1 11 1 11 J I1 j 11 1 1 -- ------------------1-------------------------------- k n t 14 IHISTO- 1 |LOGICAL JESTJMATEO) |CONFIRM-1 EXPOSURE OCCUPATION jATION k LEVEE 1 15 1 ( |OTHER |CAREER 1 1 |HIGHLIGHTS) 16 OTHER COMMENTS i1 k Yea t High | Worked |regutarly 11 it PVC are | In the (early day* |waa a | reactor (cleaner i1953-75. | Yea 1 Hl*h I Horani 11963-19021 jHTOgceaalonl |froa helperl (to aenlor (operator. Icleaned | reactora, (stripping land Irecovery ______ 1 ... _ __ Ik informalIon (froa Or M N given in Johnaon letter 09.06.04 1 t k ( i l i l (Throabu rytopenla and leukopenia since (since 1976. Gold treatment for artlirlcla (1976. Under Or1* care about 6 aontha (before death, had paaaed atandard phyaical leraalnat Ion 3 aoittha earlier. J Barr | letter* of 22.10.04 and 23.01.05. 1 1 1 1 1 11 J 11 1 11 J 1t 1 11 1 1k i1 11 ii I i 1 1 ik 39 |J Healce |27.06.10|Pantaaote )Paaaalc | I960 j March 1 lk 1 t 1 k904 t J1 1 11 i 11 k 11 1 11 k k1 1 1J 1 kt 1 11 k 11 1 j1 111 1 11 1 11 1 I1 l t1 1 1l 1 t1 i 11 1 1j 1 11 ( 11 1 kl i1 I 1 11 1 1 ( i 1 1 1 i1 1 1 i i 1 1 i1 k 1 l1 1i1 li1 *i1 *i1 t i1 t ik 1 1l 1 l1 1 lt k ll 1 |well aa 1 1 Icharglng J 1 1 1i i koperator. k 1 |Never In hoapltal for any chronic or 65 1 24 1 23 (29.06.04 1 Yea J Low (29.09.60 - (Worked (acute aedlcai profiles*. Death certificate 1 |Hay 66 |belore Jetatea cruse of death cardlo-pulaonary 1 |Vinyl 11960 (arreat aecondary to angloaarcoaa of k J Fabrlcat Ion (with US (liver. 1 (Plane (Air (Letter of 15.07.0b Iron John E Erie! 1 1 HiKh (Hay 66 - |Force, (of Pantaaote with letter of 24.02.06 k (Aug 70 lUulted | f roa Dr Auerbach. Pal ho log lat. i |Ut11lty | Wool 1 k |Realn | Dyer* 1 t (Operator land 1 i |(Inc Jul 66|0kan)te i (- Sep 67 i |Reactor 1 1 1 k | ) tOperator | | i1 ow Sep 70-62 |Mo mine t 1 i (operalor k | |Low I9H2-6 t i | HU l i | at 1(LJper or t 1 1 |l Ca1 endar l i | Shop , ont 1 J 1 i | r el J reueul 1 9 8 6 6 0 0 VWO Page 12 ICI CHEMICALS 6 POLYMERS UPX/ASL2 - LANCIOCASES,7 USA Sheet 6 LIVER Angloaarcoaa Caaea - (Heview Hate: J January 1966) UK ayalea of dates DAY - MONTH - YEAR i 1 1\ 1 1 ' | 2 | 3J A k 5 Ib I 1 i * i9 | to 1 IJ 1 i n i it 1 1 L "J i Jt> JL J 1 J J JL 1J 11 1 1 \ I JYEARS OF | |HISTO- COUNTRY AND (NAME OR | DATE OF| k |FIRST VC (DATE OF |ACE AT (EXPOSURE | YEARS OF| DATE OF |LOGICAL (ESTIMATED! 1 1 |OTHER REFERENCE |INITIALS! 8IRTH | COMPANY | FACTORY | EXPOSURE (DtttNOSIS (DIAGNOSIS)TO 1 EXPOSURE! DEATH |CONFIRM (EXPOSURE (OCCUPATION (CAREER ( OTHER COMMENTS NO 1 1 1 1 1 k (DIAGNOSIS! ATION |LEVEL (HIGHLIGHTS USA AO JL L 11 |P P | 2b.10.1 At RPC J J J_____________ _______________ L L I * 11i i1 |Loula- 122.05.42 | 1967 1 72 k AS | 3A | 03,01.87 1 Yea t Nigh | Cheat cal k t |Letter froa Dr Dietz, RPC, iCllaer (vtUa k i 1 (19A2-]97A|Worker i (10,3.67 [1 1J i t1 |19A2-A5 i l1 11\ 1 ( Low i k1 1\1 k | 197S-J976IForeaan i 11 1k1 11 II9AW6 i JL L k J J J Jt J J! ti 1\ 1 1 A 1 |R Rucfcley 7 19IS | ktodyear {Niagara 1? late | I9H? i 72 ( ? AOt | 7 30 | Al Ive | 7 Yea l i i | Letter 1 roa Prof Taaburro l1 1 | 19A0* a \ approx | !( i (University of Louisville 11 k1 1 11 k k1 I1 1 !1 ( kk LJ ___________ L k1 1 J________ J_______ L 1k J______ J__________________i o a: > 009987 Page 33 YUGOSLAVIA ICl CHEMICALS A POLYMERS LIVER Angioaarcoaa Case* - {Review Date: J Jan IV(id) WPX/ASL - LANG 10CASES. 3 J COUNTRY AND NAME OR DATE Of REFERENCE INITIALS RIRTH YUGOSLAVIA 01 05.04.14 Jugo VInll n.n.n Jugo VInll Ik.06.10 Jugo VInll 12 FIRST VC EXPOSURE DATE OF DIAGNOSIS ACE AT DIAGNOSIS YEARS Of EXPOSURE TO DIAGNOSIS YEARS Of EXPOSURE DATE Of DEATH HISTO LOGICAL CONFIRM ATION ESTIMATED EXPOSURE OCCUPATION LEVEL OTHER CAREER HIGHLIGHTS OTHER COMMENTS Split 00.00.55 os.04.7i Spilt 00.00.50 12.07.71 Split 15.12.SS 03.09.76 20 08.04.71 IS 12.07.71 18 03.09.78 VCM Productlo SAK1C et al paper Env Health Perepee live Vol 17. pp 189-192 I9?b *ln hla letter of 1 Oct 1978, Dr Splrtaa of NIOSH changed the atatua of Caae 02 to VCH production eaployee. Dr Splrtaa alao notified a new Caae 03 alau a VCH production worker. Ruae Kaalnakl letter of J9 June 1980 and I ARC letter of l April 1982 CMA 0 0 9 9 8 8 Page 34 TABLE (Review Date - 1 Jan 1988) Incidence of ASL Cases Per Annum | By date of death 1955 ............................................................................................ 1 6 ............................................................................................ 0 7 ............................................................................................ 1 8 ............................................................................................ 0 9 ............................................................................................ 0 1960 ............................................................................................ 0 1 ............................................................................................ 1 2 ............................................................................................ 1 3 ............................................................................................ 0 4 ............................................................................................ 2 5 ............................................................................................ 0 6 ............................................................................................ 0 7 ............................................................................................ 1 8 ............................................................................................ 5 9 ............................................................................ 3 1970 ............................................................................................ 2 1 ............................................................................................ 3 2 ............................................................................................ 5 3 ............................................................................................ 8 4 ............................................................................................ 5 5 ............................................................................................. 11 6 .......................................................................................11 7 ........................................................................................... 9 8 ............................................................................................. 10 9 ........................................................................................... 5 1980 ............................................................................................. 10 1 ........................................................................................... 5 O 2 ........................................................................................... 3 3: 3 ............................................................................................. 10 4 ........................................................................................... 7 0099S9 5 ........................................................................................... 6 6 ........................................................................................... 3 7 ..........................................................................................^ Total 129 N. B. 1 Does not include Italian 01 but does inc lude German '03. 2 The 1977 totaL includes US case 24 which is a Cholangiosarcoma. 3 Does not include the following who are still alive, so far as known: Canll, Pr 15 A 22, 031 A 32, UK] 4, US3 1, 3ti 4 41 Page 35 Distribution of ASL Cases by Country TABLE 2 (Review Date - 1 Jan 1988) USA W Germany France UK Canada Sweden Italy Yugoslavia Japan Czechoslovakia Belgium Norway 38 AA A 31 A A AAA 22 AAA 13 AAA 12 AAA 5 A AAA 5A 4 AAAAA 3 2 2 1 Total 138 CHA 0 0 9 9 9 0 * Omit ItOl - atypical case of PVC bag extruder. ** Includes G03 aerosol can filler. *** Includes case US 24 which was diagnosed as Cholanglosarcoraa; & Canll, Frl5 & 22, G31 & 32, UK14, US33, 36 & 41, who are still alive, so far as known. **** Includes one monomer worker. ***** Includes two monomer workers. i ,e Western Europe North America Rest of Wo rid 79 50 9 Tota 1 738 WPX/ASf '> i.ANOIOOASFS 111 Page 36 Pattern of ASL Cases by Factory TABLE 3 (Review Date - 1 Jan 1988) (a) W Europe ------------ I Of the 79 cases in W Europe, 68 have occurred in clusters at 12 factories. Of the 31 Cerman cases, 28 have occurred in clusters at 4 factories. ASL Cases Dynamic, Troisdorf, Germany BP, Barry, UK Wacker, Burghausen, Germany Atochem (formerly Chloe Chlmie, formerly RP), St Fons, France PCUK, Brlgnoud, France Kemanord, Sundsvall, Sweden CWH, Marl, Germany ICI, Hillhouse, UK Solvay, Tavaux, France Lonza, Waldshut, Germany Solvay, Jemeppe, Belgium Atochem, St Auban, France 12 10 9 8 7 3 4 3 3 3 2 2 68 NB: There are 32 pre 1962 PVC plants in W Europe; 18 of these have had ASL cases (Ref Table 8) (b) N America Of the 50 cases in N America, 42 have occurred at four factories out of a total of 55 factories. In N America 43 plants have not had ASL cases. ASL Cases BFG, Louisville, US BFG, Shawinlgan, Canada UCC, S Charleston, US O Goodyear, Niagara Falls, US jt 3> 15 12 10 _5 42 NB: There are 29 pre 1962 PVC plants in N America; 12 of these have had ASL cases (Ref Tables 9 4 10) O 'O >0 'O (c) Rest of World The 9 ASL cases are believed to be in one cluster of 4 and two clusters of 2 cases. WPX/ASL2 - LANGIOCASES,11 Page 37 TABLE 4A (Review Date - 1 Jan 1988) Latency Periods {Years from first Exposure to Diagnosis) Count r^ No of Cases Total Years Average W Europe Belgium 2 35 17.5 France 22 574 26.09 * Germany 31 632 20.38 * Italy 5 99 19.8 Norway 1 22 22 Sweden 5 122 24.5 N America UK 13 293 22.53 * 79 1777 22.49 W Europe Average US 37 955 25.81 * Rest of World Canada 10 205 20.5 * A7 1160 24.68 N America Average Czechoslovakia 2 30 15.0 Japan 3 59 19.66 Summary Yugoslavia 4 9 85 21.2 174 19.33 Rest of World Average W Europe 79 1777 22.49 o 3 > N America 47 1160 24.68 o o Rest of World 9 174 19.33 <1 <1 1 31 5 . 3111 23.04 * World Average >0 M * Of the countries with > io cases. France, and USA have an average latency period above world average; Cermany, UK and Canada below world average. NB: Do s not include Canl1 or 12, or USA 1: details not known. Page 38 DISTRIBUTION OF LATENCY PERIODS TABLE 4B (Review Date - 1 Jan 1988) 1 1 1 1 1 1 1 11 1 1 1 1 1 1 1 1I | 0-9 yrs 1 10- 14 yrs | 15-19 yrs ( 20-24 yrs | 25-29 yrs 1 30-34 yrs 1 35+ yrs || Total 1 1 1 1 1 1 1 11 1 1 1 1 1 1 1 11 1 1 1 1 1 1 1 11 Belgium 1 1 1 21 1 1 1 11 2 1 I1 I1 11 1 11 Canada ** 1 1 31 1 5| 21 1 1 10 1 Czechoslovakia | 111 1 1| 1| 1 [ 11 11 2 1 I Average ( Latency t Period I(Table 4A) l 1 17.5 1 1 20,5 1 1 13.0 11 1 1 1 11 1 France 1 1 1 | 4 | 3 | 8 3 3 1 1 22 | 26.09 11 1 1 ! 11 1 Germany 1 5| 9| 10* | 5 2 1 1 31 1 20.38 11 1 1 1 11 \ Italy 11 i 21 21 1 1 1 1 5 1 19.8 Japan 11 11 i 11 111 i 1| 21 i 11 il Ii 1 II 3 | 19.66 Norway Sweden UK USA ** 11 11 1i 1 |11 1 1 i l i 1 1 1 21 i 11 21 1 5| 1 7| 1| 1 i 1 l| i 91 1 21 4 8 1 11 2 5 11 1 | 22 ]l 1 11 5 | 24.5 1j E 1 1 13 | 22.53 11 \ 6 | | 37 | 25.81 1 l i i 1 1 1 11 i Yugoslavia 1 1 i i 4I 1 1 11 4 l 21.2 O TOTAL ** 3: > 1t 1t |11 (1 i i 12 | 1 i i 33 | 1 t 1 37 1 1 1 1 30 1 1 I 1 13 1 1 11 1 11 1 9 I 1 135 I 23.04 11 1 o * Includes G 03 aerosol can filler <0 -0 'O ** Does not include Can 11 o r 12 , or US41: details not known 1 w WPX/ASL2 - LANCIOCASES,l3 TABLE 4C Page 39 (Review dace l January 1988) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE MAX POSSIBLE I YEAR OF 1 LATENCY PERIOD | ARITHMETIC MEAN I LATENCY YERIOD 1 FIRST EXPOSURE 1 (NO OF YEARS) | OF LATENCY PERIODS 1 11 48 I 1939 1 38* 47 I 1940 1 46 I l 1 37,21,37,41 45 1 2 1 32,38,45 11 |I 1 289 3 36.12 1 | "8 1 |1 44 1 3 I 38,14,32 | 1 1 4 1 28,11,24,20,24,34,39 | 718 St 26.59 1 I 5 I 27,22,28,29 | 27 1 1 6 1 21,29,31,26,28,15,23,1 1 1 1 30,35 40 | 7 1 29,24,29,28 39 | 8 1 28,24,34 1 9 1 30,26,20 |1 I1 |1 | 521 = 24.80 1 I 1950 I 26,22,31,19,23,14,33 | 21 1 t 1 1 19,28,17,28,34,29 | I 35 1 2 1 21**.15 | 1 34 | 3 1 25,22,23,22,20,31,22,1 1 1 1 32*** | 1 1 4 1 21,21,25,25,21,28***,| 1 1 1 22 .1 787 a 22.48 1 1 5 1 22,23,24,14,19,21,27 > 35 1 1 1 27*** 24,28,30*** I ! 6 1 21,12,27*** | h 30 1 -.7 . . I 19,17,15,13,16,28 | 1 29 ! 8 I 18,18,15,17,20,29*** | 1 1 9 1 16,21,25,27 | 544 = 18.75 1 | 1960 1 13,18,21,25,24,25 | 29 1 | 1 1 15,16,16,16,19,19,12 | 1 25 1 2 1 13,18,17,12.18,21 | 1 24 1 3 1 16,17,20,21 I 1 1 4 1 16,17 | 221 a 17.0 I | 5 1 11,19,20 I 13 1 1 6 1 9,18,21*** I 1 20 | 7 1 16 I 1 19 1 3 1 18 1 9 1 13 I 1970 1 1I 1 31 = 15.5 I 12 I VIOLA 1 15 1 2 14 1 3 1 11 1 I MALT0NI 1 I TOTAL 1 4 1 1 135 CASES 1 1 I GOODRICH I 3111 a 23.04 1 135 * Cholangiosarcoma ** Aerosol can filler *** The following are still alive, so far as known Frl5 and 22, G31 and 32, UK14, US33 and 36 NB: Does not include Canll or 12, US41: details not known <X <X o O WPX/ASL2 - LANGIOCASES,14 TABLE 40 Page 40 (Review date [ j.anuary 1988) LATENCY PERIODS OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND GEOGRAPHTCM ~~ LOCATION --------------- ------- - MAX POSSIBLE 1 YEAR OF I LATENCY PERIODS IN LATENCY PERIOD 1 FIRST EXPOSURE I WESTERN EUROPE | NORTH AMERICA 11 1 48 1 1939 1 I 38* 47 1 1940 1 1 46 1 45 1 1 I 37,41 21 | 21,37 I 32,38,45 44 1 1 3 1 38 4 ! 28 | 14,32 | 11,24,20,24,34,39 1 5 1 27 | 22,28,29 1 6 1 21,29,31,33 I 26,28,15,23,30,35 40 I 7 1 29 | 24,29,28 39 1 8 1 28,34 I 24 1 9 I 30,26 | 20 1 1950 1 26,22,31 | 19 1 1 1 19,28,34,29, | 17,28 35 1 2 I 21** | 15 34 1 3 1 25,22,22,32*** | 23,31 1 4 1 21,21,25,25 I 21,28*** 1 5 I 22,23,24,27***24,281 14,19,21,27 1 1 30*** | 1 6 1 21,12 | 27*** 30 1 7 I 19,17,15,13,28 | 29 1 8 I 18,18,29*** | 15 1 9 I 16,21,25,27, | 1 1960 I 13,18,21,25,25 | 24 1 1 1 15,16,16,16,19,19 | 12 25 1 2 I 13,18,17,18,21 | 12 24 1 3 1 16,17,21 | 20 1 4 1 16 | 17 1 5 1 11,19 | 1 20 1 6 | 9,18,21*** 7 1 16 | | 19 1 8 I 18 | 1 9 I 13 I 1 VIOLA 1970 1 1 11 21 1 1 MALT0NI 3 1 1 1 TOTAL CASES 1 79 1 47 ' 1 ROW | 1 | 1 1 1 1 I 1 I 1 I 1 1 23,14 | 1 1 I 22,20 1 1 22 | 1 1 1 1 16 | 1 17,20 | 1 1 1 1 1 ! 20 I 1 1 1 1 1 1 1 19 | 1 * Cholangiosareoma ** Aerosol can filler *** The following are still alive, so far as known Frl5 and 22, G31 and 32, UK14, US33 and 36 NB: Does not Include Canll or 12, or US41: details not known WPX/ASL2 - LANGIOCASES,15 i Page iL TABLE 4E (Review date 1 January 1988) PLANT -- 11 I START 1 I UP 1 I DATE 1 LATENCY PERIODS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) 11 | NO OF | AVERAGE I CASES | LATENCY PERIOD 11 11 11 LOUISVILLE USA 11 1 I 1940? 1 12,14,15,19,19,20,24,27,28,28,28,29 29 I 1 1 31,45 1 1 15 1 1 24,53 years TROISDORF 11 I 1954 1 12,13,16,16,18,19,19,21,23,25,28,29 1I 1 12 | 19.91 W GERMANY i ! ii SHAWINIGAN 1I I 1943 1 11,12,14,21,22,23,24,24,26,28 l1 1 10 | 20.5 CANADA 1(1941?) 1 ii 11 S CHARLESTON I 1939? 1 24,30,32,32,34,35,37,38,38,39, Ii 1 10 | 33.99 USA i1 1! ii BARRY UK I 1948 1 1 1 9,17,18,28,31,33,18,19,18,21 1 1 1 10 | 11 11 21.20 MB: Does not include cases Canl1 and 12 at Shawinigan: details not known WPX/ASL2 - LANGIOCASES,16 CMA 009996 Page 42 TABLE 4F (Review dace 1 January 1988) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPECIFIC PLANT (10 OR MORE CASES) * I YEAR OF FIRST | LOUISVILLEI TROISDORF I SHAWINIGAN I S CHARLESTON | BARRY ! EXPOSURE I USA 1 W GERMANY I CANADA I USA 1 UK 1 1939 1 1 1 I 38 1 1 1940 1 1 1I I I 11 1 1 21 I 37 1 I 21 1 1 1 32,38 I I 31 1 I 14 I 32 1 1 4 I 20 1 1 5 1 28,29,27 1 1 11,24 I 22 1 24,34,39 1 1 1 1 61 1 1 26,28 I 30,35 1 1 7 I 29,28 1 1 24 1 I I 8 1 24 1 11 1 1 91 1 11 1 1 1950 1 19 1 I1 1 31,33 1 11 1 29 1 1 I 28 I 2 1 15 1 11 1 1 3 1 31 1 I 23 1 1 1 4 1 28 1 21,25 1 1 5 1 14,19 1 23,28 1 1 1 1 1 1 61 1 71 1 12 1 13 1 1 I 1 1 1 1 81 1 11 1 9I t 11 I 1 1960 11 1 1 11 1 16,16,19,19, 1 12 1 1 j 1 2 1 12 1 18 1 1 1 18 1 31 1 41 1 1 11 11 I 17 1 1 51 1 11 I 19 1 61 1 11 1 9,18,21 1 71 1 11 1 I 81 1 11 1 18 19 1 11 1 1 1970 1 1 11 I 1 11 1 11 1 1 21 1 11 1 NB : Does noc include cases Can11 and 12 at Shawinigan: details not known WPX/ASL2 - LANGIOCASES,17 CMA 009997 TABLE 4G (Review date l January 1938) 1 PLANT | 1I 11 I BURGHAUSEN | 1 W GERMANY | 1 1 ST FONS 1 FRANCE 1 | | 1 1 BRIGNOUD 1 FRANCE 1 | | I I 5UNDSVALL 1 SWEDEN 1 | | 1 1 NIAGARA 1 USA 1 | I 11 1 SPLIT | 1 YUGOSLAVIA! 1I I MARL I 1 W GERMANY | 11 3TART-UP DATE I LATENCY PERIOD OF ASL CASES 1 IN SPECIFIC PLANTS(4-9 CASES) 1 1933 1 17,21,22,25,24,13,21,32,30 1 ! 1939 ! 21,28,29,37,38,27,41,34 1 1 1950 I 11,16,18,26,30,25,34 i 1 1945 I 16,19,27,29,31 i 1947 1 1 15,17,21,23 i 1950 1 1 20,20,22,23 i 1948 1 15,16,22,21 1 ! NO OF 1 AVERAGE PERIOD CASES 1 1 9 I 22.77 years I 1 8 I 31.88 1 1 7 1 22.85 1 1 5 1 24.4 1 1 4 1 19 1 1 4 1 21.25 1 1 4 ! 18.5 1 1 NB : Does not include US41 (Niagara): details not known WPX/ASL2 - LANGIOCASES,18 CMA 009998 Page 44 TABLE 4H (Review date 1 January 1988) LATENCY PERIOD OF ASL CASES TABULATED BY YEAR OF FIRST EXPOSURE AND SPFCTFTn ptjmt (4-9 CASES) ' ------------------ -- 1 YEAR 01 BURGHAUSENl 1 FIRST EXPOSURE W GERMANY 1 1 1 19 39 I 1940 11 I2 !3 1 1 1 1 1 1 14 1 15 1 16 I7 1 1 18 1 19 1 1950 1 ! 1l 1 12 1 1 3 25,32 I I 4 21 | 1 5 22,24,30 I 16 1 I 7 17 | 18 1 19 1 1 1960 21 ! 11 1 12 1 13 1 14 1 15 1 16 I7 1 1 18 19 I 1970 11 13 1 I 1 1 12 1 I ST FONS FRANCE 37,41 38 29 28,34 27 21 BRIGNOUDl FRANCE 1 1 ! 1 I 1 1 I 1 1 1 I 26,30 I 1 1 34 1 1 1 1 1 1 18 16,25 1 1 1 1 1 1 1 1 11 1 1 1 I 1 1 1 1 1 SUNDSVALLl SWEDEN I 1 1 1 1 1 1 I 1 27* 1 31 1 29 1 1 1 1 19 1 1 1 1 1 1 1 1 1 1 1 1 16 1 1 1 1 1 1 1 1 I 1 NIAGARA 1 USA I 1 1 1 15,23 17 21 I 1 I I 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 1 1 1 1 1 I 1 1 1 I 1 1 1 SPLIT | marl | YUGO-|y GERMANY^ SLAVIA1 | 11 || I 1 1 1 1 I t 1 1 1 23* | 1 1 1 1 1 1 1 1 1 1 | 1 1 20 | 22 22* 1 1 1 | | 11 11 11 20 | | 1*1 1 115,16 121 1 1 1 1 I 1 1 1 1 1 1 1 I I 1 1 1 1 1 1 1 ! I 1 I Monomer worker NB: Does not Include US41 (Niagara): details not known WPX/ASL2 - LANGIOCASES,19 CMA 009999 Page A5 TABLE 5 (Review Date - l Jan 1988) Annual Incidence of ASL Cases (Date of Death) by Geographical Area t 1955 7 1961 2 4 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 1983 1984 1985 1986 1987 TOTAL 1 1 !1 | Western Europe | North America | Rest of World | Annual Total 1 11 1 11 1 1 11 1 1 11 1 1 11 1 1 11 1 11 ( 1 1 i5 1 11 12 t 11 11 ! 11 I2 ( t4 |1 f 11 13 14 12 1 t t6 |4 1 16 |3 1 16 |3 1 17 15 |2 |- 1 1 16 |4 1 15 |0 1 11 12 t 17 |3 1 15 I2 l 15 | 1 13 | 1 1 11 1 1 74* ** | 46** l t 11 11 11 11 1|2 11 15 13 12 13 15 3I 8 |5 1 | 11 2 1 11 19 1 | 10 |5 10 |5 13 10 17 1I 6 13 11 9 1 129 1 Cumulative | 1 Total | Key Events 1 11 12 1 1 1 13 14 16 17 1 12 1 ! 1 1 1 1 15 1 17 1 20 1 25 1 33 1 38 1 49 1 60 1 69 1 79 1 84 1 94 1 99 1 102 1 112 1 119 1 125 1 128 1 129 1 | Viola 1 1 | Maltoni | Goodrich 1 1 1 1 1 1 ! 1 1 1 1 1 1 1 * Includes GO3 aerosol can filler but omits It 01 hag ext ru1 der ** Does not include the following who are still alive. so far as (nown: UK 14, US33, 36 & 41 Can 1 1 , Er 1 5 and 2 2, G31 & 32, CHA 010000 Page 46 TABLE 6 (Review date 1 January 1988) ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING It. 01) KEY EVENTS -1 WESTERN EUROPE NORTH AMERICA REST OF WORLD 1955 6 7 8 9 1960 1 2 3 4 5 6 1 7 1 FI Viola !8 19 I 1970 11 1 1 G1 1 Swl 1 G2 1 Maltoni | Goodrich | 1 2 I N1,Sw2,UKl,It2 3 1 G3***** 4 1 G4.G5.UK3 5 1 F2,F3,G6,G7,G8,It3 1 6 1 B1 ,F4,F5,F6,F7,Sw3 1 7 1 F8,F9,G10,G11,G12,Sw4 18 1 19 ! 1980 11 12 13 14 1 F10, FI 1,G9 ,G13,G15 1 G16.G17 ! FI 2,FI 3,UK4,UK5,G18 1 UK6, UK7,G19,Sw5,G20,G21US 1 It4,F14,UK8,G22,G23 1 G26 I UK09,It5,Fl7,B2,G24,G25,G30 1 UK10, F16, F18, G27.G29 1 5 1 UKU, UK12, FI 9, F20 ,G28 1 6 1 F21,UKl3,It6 1 71 Total 74*** Cl C2 US8 C3 US5 Cz2 C4 ,C5 ,US4,US7,US10 US12.US16 USl 1 C6.US2 C7 C8.US1,US3,QS23 C9.US13 US6 ,US9,US18,US26 US19,US20,US22, C10,US21,US24* US27.US28 I 1 1 I 1 1 I Y1,Y2,Czl 1 1 Jap 1 1 Jap2,Y3' 1 1 Y4 1 1 USl7, US29, US30,US32| US31,Cl 2 US35, US34, US38 US37.US39 1 1 1 1 1 Jap3 US40 1 1 * Cholanglosarcoma ** Aerosol can filler *** Does not Include the following who are still alive, so far as known: Frl5 & 22, G31 & 32, UK14, US33, 36 & 41 Canll, WPX/ASL2 - LANGI0CASES.21 CMA OlOOOl TABLE 7 Page 47 (Review date L January 1988) ASL CASE NUMBERS BY YEAR OF FIRST EXPOSURE AND GEOGRAPHICAL LOCATION (EXCLUDING It.01) "` KEY | EVENTS | 1 | WESTERN EUROPE 1 1 NORTH AMERICA 1 I REST OF WORLD 11 1 1 11 1 1939 1 1 40 1 1 1 IFrl 1 ,Frl6 1 21 1 3 1 Frl4 1 4 I UK1 1 5 I Sw2 1 6 |Frl,Fr3,Sw4 1 7 1 Sv3 1 8 |Fr9, Frl7 1 9 IFrl2,Fr4 1 50 IFr7,Nl.UK8.UK9 11 1 US24* 1 1 1 C3.US27 1 1 1 US13, US29.US40 1 C2.US19 1 1 1 C1,C5,US5,US7,US28,US35 1 1 C4.US3.US9 1 1 C7,C9,US8,US11.US21.US31 1 1 C6.US22.US26 1 1 US1 1 1 US12 1 I US16 IY2, Cz2 t 1 |Swl,UK5,Fr20,G30 I US10, US32 1 2 |G3***** 1 US4 1 3 |G15,It3,G26,G3l*** 1 CIO, US37 1 4 I G7,G8,UK4 ,G 19 I USI8.US33*** 1 5 I G11,G16 ,G 18, Frl 5* ** 1 US2 ,US17,US20;US34 1 I G23,G28,G32*** 1 1 6 IFR10.G1 | US36*** 1 7 |Fr8,G4,It2,G2,UK12 1 1 8 |Fr6,81,Fr22*** I US23 1 9 !Fr2,It4,Frl9,Fr21 1 1 60 IG5,Gl3,G25,G28,It6 1 US39 1 1 |G9,G10,G12,G17,G20 ,G 2 21 C8 1 2 |G6,UK6,G21,B2,G29 I US6 1 3 1Frl3, UK7,Frl8 1 US38 1 4 I Sw5 I US30 1 5 I-Fr5,UK11 i 1 6 1UK3, UK10.UK14*** 1 1 7 I It5 1 1 8 IUK13 1 1 9 1 G24 1 Viola | 70 1 1 1 1 IJapl,Y1 1 Y3 1 1 ICzl 1Jap2,Y4 1 1 1 1 1 1 1 Jap3 1 I 1 1 1 1 11 1 1 1 Maltoni | 21 31 1 I 1 1 11 Total 179 1 1 47**** i 19 11 1 1 * Cholangiosarcoma (US24) ** Aerosol can filler (G3) *** Frl5 & 22, G31 & 32, UK14, US33 & 36 are still alive, so far as known **** Does not include Canll or 12, or US41: details not known VPX/ASL2 - LANGIOCASES,22 CMA 010002 LIVER ATCIOSAHXttt. GASES CIUFIHWITAL FEBRUARY 1988 CTRCULATICN OF REGISTER RAGSHAW Dr I MM BAM) Dr P R BARON Dr C BARRAT Dr G BAXTER Dr-Peter BAYLAC Dr BEAUPRE M BELLEC Dr BENECH Dr M BENNETT Dr B BERTAZZI Dr P BISHOP Dr C BORRELLI F E BOYER R W BRAUN DrCU BREWER Dr M BRYSON Dr D D BURGESS Mr David BYREN Dr David GARTER Dr J T CATAfEARITI A CELLA Mr C CHANCE ffr M CLARKE Dr E A CLAUS ft P G CLAYUN Mr H OONEASSOT Dr J C DAVIES Mr J G DEJONG Dr G DELORfE Dr F DEPLAN Dr DE VOS Mr A J DIETZ Dr H W DOLL Sir Richard DOMBROWSKI S L DRUMWRIGHT Dr J R DUPONT Mr G EMMINGER Mr H ERNST Dr W EVAfE Dr A E J FALK, Dr H FAVRE Dr FERGUSON Dr D M FINCHAM Mb StiLrley POfWAN Dr D FR4X R W FRUDEL Dr H F QOSZTONYI Jnr Dr GOTIESMAN R T HARRIS Dr W D HENDERSON I B HILLMAN DrDW HLNDERER Dr R K HOWARD Dr J K tUOTFY Dr N F JAUVERT Mr J JERVIS ft H R JONES Dr R D ftorsk Hjdro, Newton Aycliffe, UK Cancer Control Agency of British Cblanbia, Vancouver, Canada ICI Runcorn, UK AECRP, Caanentry, France University of Canbrldge, UK Atochan, Chauny, France Goverment of Quebec Career Registry, Panada Krone Poulenc, Ajbervillers, France Naphtachimie, Lavera, France ICI Htllhouse, UK Inst of Occupational Health, Milan University, Italy EMAS, Cardiff, UK Georgia Gulf, Delaware City, USA Formosa Plastics, Delaware City, USA Akzo, Amhen, Holland Imperial Oil, Sarnia, Ontario, Canada ICI Btllinghan, UK ICI Americas, Wilmington, Delaware USA Kemanord, Stockholm, Sweden EMAS, London, UK EVC, Brussels, Belgian EVC, Brussels, Belgian ICI Runcorn, UK Ontario Cancer Foundation, Toronto, Canada APME, Brussels, Belgian Norsk Hydro, Newton Aycliffe, UK Atochem, Saint-Fans, France ICI, Everberg, Belgian Shell, An Den Haag, Holland Quebec, Canada Atochan, Jarrle, France EW), Welwyn Garden City, UK B F Goodrich, Akron, Ohio, USA Imperial Cancer Research Find, Oxford University, UK Dow Chemical, Midland, Michigan, USA Vista Chemical, Houston, Texas, USA AFME, Brussels, Belgian VKE, Frankfurt, Germany Berufsgencssenschaft der ChenrLschen Industries, Numberg, Germany Lever Bros, Warrington, UK Chronic Diseases Div, US Dept of Health & Honan Services, Atlanta, USA Atodiem, Montluel, France ICI Americas, WLlmington, Delaware, USA Alberta Cancer Board, Edmonton, Canada Imperial Cancer Research Raid, Oxford University, UK Diversilfech General, Akron, Ohio, USA Berufsgenossenschaft der Chendschen Industries, Heidelberg, Genany R E Tenneco Chemicals, Plscataway, New Jersey, USA The Vinyl Institute, Wayne, NJ, USA Uniroyal Inc, Middlebury, Connecticut, USA ICI, Hillhouse, UK Diamond Shamrock Corp, Dallas, Itexas, USA BF Goodrich, Qeveland, Ohio, USA University of Otago School of Medicine, Wellington, New Zealand ICI Australia, Melbourne, Australia Chloe Chimie, Paris, France ICI Mtllbank, Lorcton UK EMAS, Bootle, UK CMA 0 1 0 0 0 3 WPX/ASL - ASL ADDRESS,! KAIPEFT Dr J H KARRH Dr Bruce KLEIN Dr H KHEUGER Dr R A LAGAST Dr H LALOINE Dr J P LANHAM Dc. John LANCUZIERE Dc LAWRENCE-JONES LEE Dr F I LELBAffl Prof C LEVEQUE Dr G LEVTSON Dr D A LEWIS Dr P LOLITOR Hr LUSS R D LLJSSAID Dr Josette MAIILARD Dr J M MALTONI Prof C MARGETIS, Mr R J MATCRE Prof Lo MATTIUSSI Dr R MIDDLETON D MDKKA Mr MONIESANO Dr R HOTO Dr A A KJNce nxntN Dr m HacSWEEN Prof RIM NAKAMJRA Dr S OLSON H G OWEN Dr R PADDLE Dr G M PAGUALUNGA Dr S PAOUEI Dr PA1ERSCN Dr J C PIRASTO Dr Roberta POPPER Dr Hans POSSBERG Dr J PUECH Dr AM PURDHAM Dr J RAMBAUD Dr J RICHARD Dr P ROBSCN Mrs D RODRIGUES ET MJF ROUST Dr G RUTY Dr J SAIG Dr Joyce A SARAOd DT R SOHTEBS Dr T M L SCHIPPER Dr H SERCTOE Dr D SHAH Dr Has SIGRIST Dr J SMITH Prof Allan H SMITH Dr E SMITH It J S SMITH Dr P M SPIRXAS Dr R STAFFORD Dr J STAHNECKER Mr SULAIMAN Dr 2- - Dow Chanical Europe, Horgen, Switzerland Dupont, Wilmington, Delaware USA Dynanlt Nobel, Troisdorf, Germany HF Goodrich, Akron, Ohio, USA Solvay, Brussels, Belgian Solvay, Brussels, Belgian Dow Chanical, Midland, Michigan, USA Solvay, Tavaux, France Sir Qiristopher, Chief Nfedical Officer, ICI, Lcrcion UK Victoria Hospital, Blackpool, Lancs, UK University of Bonn, West Germany CDF Chimie, AZF, Bully-les-Mines, France St Bartholomew's Hospital, London, UK Chanical Industries Association, London, UK Solvay, Brussels, Belgian Occidental Chanical, Pottstown, Pennsylvania, USA Atochan, France Suva, Luzern, Switzerland Institute di Qcvcologia, Bologna, Italy ICI Directorate, Wilton HQ, UK Msdil-Anic-S, Milan, Italy Montedison, Milan, Italy Norsk Hydro, Newton Aydiffe, UK Neste Oy, Espoo, Finland 1ARC, Lyon, France Duperial SAXC, Buenos Aires, Argentina Rio Rodano, Madrid, Spain Wfestem Infirmary, Glasgow, Scotland Japanese PVC Association, Tckyo VC Safety Association, Louisiana, USA Trades Union Congress, London, UK ICI Central Medical Group, Alderley Park, UK Montedison, Novara, Italy Atochan, Serqulgny, France Id Runcorn, UK Istituto Superiore di Sanita, Rone, Italy Mount Sinai Medical Center, New York, USA fecker-Chenie, Mmich, Germany Atochan, Brignoud, Fiance Canadian Centre for Occupational Health & Safety, fenilton. Canada iff Recherches, Antony, France Fhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada Id, Sao Paulo, Brazil Monsanto, St Louis, Missouri, USA Atochan, St Auban, France NIOSH, Cincinnati, USA IARC, Lyon, France DSM/CVM), Celeen, Holland University of Manitoba, Winnipeg, Chnada Diamond Shamrock, Dallas, USA CMA, Vbshington DC, USA Snell Chimie, Berre L'Etang, France University of California, Berkeley, USA Division of Environmental Health, World Health Organisation, Geneva, Switzerland ICT HUlhouse, UK Llandough Hospital, Penarth, UK NCI/NIH, Betheada, Maryland, USA Somerset, UK CMA 010004 BASF, Ludwigshafen, Germany Arabian Petrochemical Co, Saudi Arabia WPX/ASL - ASL ADDRESS,2