Document rxvMXavozDbRZL6mVLQG930Qa

PLAINTIFFS EXHIBIT WV-00402 PLAINTIFF'S j! EXHIBIT \{ 1Q<?3.0< RifrUt*4 /r IW A. A/. A. Artk*** #1 /--* tw, va. a. th ///*A Cfyr^r /9J4, by American HffHfct FROM An Epidemiological Study of <<!S)U^i*LAveT01 Lung Caocer in Asbestos Miners 04KIII C SSAUM. Ht. v4 t. OAVIO fSUAM, M-A_ WtaSwgb h "l^T'pa" Ever since the pronounced increase in the inddcncc oi lung cancer among males became apparent, there have been attempts to associate it with one or another of the various dements in the environment of man. The approach used by some workers has been to suspect one or several sub stances and then set about in an iremsive search for lung cancer among persons who have had any exposure to those materials. In this connection. Smith" writes: "The tenderer of authors reporting the coincirlental occurrence of primary lung cancer with silicosis or with any other theoretical etiologic conditions, has been to emphasise the percentage relationship - in extremely small series of cases, with control cases which arc not in any way comparable." It would seem inevitable that asbestos should come under scrutiny in this manner, because prolonged exposure to this material b known to cause a specific type of pneu moconiosis, and bemuse persons who show this form of pneumoconiosis often cane to autopsy and provide a ready source of material for study. It was in this wsy that reports of the simultaneous occurrence of lung cancer and asbeslosis began to accu mulate after the report of a case by Lynch and Smith** in 193S. Within the next 10 years, about IS additional cases were re ported. and In I9S4 M crewether * reviewed aO deaths from asbestosis recorded in Eng land since Starch. 1924. Lung cancer oc curred in 165s of these cases. Glovne.*' Accepted lot publication Jan. A I9S& This stwl/ in mode pmitble through s (rant : from the QutUs Atbestns Mining Asyeauau. Medical Dircclur fDr. Oraon) and Statistictl Ceuiuhaut (Mr. Toon). Industrial Hygiene whose work is also, frequently referred to as establishing a connection between asbes tosis and oncer of the lung, reported in 1951 that cancer of the hmg waa present in 14.1% of asbestosis cases examined by him. In 1941, Tfordmam and Sorgcra claimed to have produced hmg cancer in mice which they exposed to asbestos dust. Since 19JL additional cases of cancer of the lung coexisting with asbestosis have been reported, and, according to Huq*r u about 10C such cases had been reported up to 1955. As a result, an association between the two diseases appears to have been ac cepted by many authors, and several writers were using the term "asbestosis cancer" of the lung. Werber," in 1952, stated cate gorically that in 7% to 17% of cases of asbestosis, after a blent period of about lyi to 20 years, carcinoma becomes estab lished in the lung. On the other hand, not all authors ac cepted this alleged association without reservation. Saupc" hi 1939 reported that he had discovered no cases of lung cancer among 620 cases of asbestosis which he had examined; and in 1942, Hollcb and AngrUt'* expressed the opinion that the number of cases of asbestosis with lung cancer was too smalt for statistical evalua tion- In 1947, Wegdros" reported 126 tadiologicilly diagnosed cases of asbestosis among 476 workers in Finland, and. found no cases of lung cancer in this group, (toldbbtt and Goldblau in their section of Merevether's blest book,** state: "But at no stage in all these impressive researches was any due obtained which might have offered any supjiort to the possibility that arhestes etnld act as : ci. .1- ... 614 1 /*/jO 3a/Xi---- / "//Vty