Document rxp2ymRRDzdJg1qwnGpB5LEaa

X-^s pi Marstsller er 2/.: Splenomegalic Liver Disease 3ruhl,' 'a'. 1966. Zwischenfalle und Xomplikationen be: der Laparq und gezielten Leberpunktion (Ergeonis einer Umfrage). Deut. Med. sehr. 91: f- 2291. Canada, Department of National Health and Welfare, Inspstrial Health Division. 1949. guide to the -diagnosis of occupatiopa^diseases. King's Printer. OtoWaTOntario, Canada. Carr, J., R. M. Burcison, ]. F. Vitcha & J. C. Krantb^Jr. 1949. Anesthesia. XXIV, Chemicai constitution of hydrocarbons andjfeairdiac automaticity. J. Pharmacol, Exptl. Ther. 97: 1. Chatelain, A. ?. Motillon. 1967. Un syndrome #pcro-ost6olyse d'origine pro- fessicneiie el ce constataiion nouvelle en France. J. Radiol. Electrol. Med. Nud. 48: 277. ...y' Chemical Economics Handbook. September J973. Vinyl Chloride and PoJyjunyT* Chloride Resins. Stanford Research Insttitdte. Menlo Park, Calif. Chemiewirtschaft in Zahlen. VersanoI^er Chemischen Industrie E.V., Ed. 1973. 15th edit. Econ-Verlag. DilssdeGorf, West Germany. )^y^l9. Chenoweth, M. B. & C. L. Hake,^W52. The smaller halogenated aliphatic hy drocarbons. Ann. Rev. PharmacapS: 363. *? 30. Chief Inspector of FactorieeJ1953. Annual Report for the Year 1951. Cmd. ^ 8772, H.M.S.O. London, Eniffiid. Cook, W. A., P, M. Giever^B. D. Dinman St H. J. Magnuson. 1971. Occupa tional acroosteolysis. IL^An industrial hygiene study. Arch. Environ. Health 22: &CL-32. Cordier, jf. M., C. Ffgjj&L. M. J. LEfEvre St A. Sevrin. 1966. Acro-otliolyse ei lisions cuunies aarapies chez deux ouvriers affect6s au nettoyage d'autociaves. Cahiers de Midejffiie du Travail (Association Professionnelle beige des M6de- dns du TravaUripjanvicr 1966). , it/33. Creech, J. L.jK& M. N. Johnson, 1974. Angiosarcoma of liver in the fcnanu- jg facture oLwlyvinyl chloride. J. Occupational Med. 16: 150. \^*4. Croll, W. Brady, I. Brodsky St L. Stanton. 1965. A new agent for ~ spleniepniining: BMHP. Radiology 84:492. <1 1/35. Dahum^/S. 1961. Thorotrast tumour^. A review of the literature and report of tyMpeases. Acta Pathol. Microbiol. Scand. 53: 147. VSK2Z, S. L. & N. M. Eoorov. 1961. Voprosyi toksikologii v khimii vyso- ilekulyarnykh soedinenii. Gigiena Truda Prof. Zabolevaniya 5 (9): 26. ER, H. I960. Accidental poisoning by vinyl chloride: report of two cases. Can. Med. Assoc. ___ inyl acetate: a study of chronic human ex- yg. Assoc. J. 30:449. Deichmann, W. B. & H. W. Gerarde. 1969. Toxicology of drugs and chemicals. Academic Press. New York, NjY. _ &Ct,Ct toxicologique exp6rimentale lanufactures de Saint-Marcel, ^emon, avril 1953. As cited in Tniffert, 1959. j D. & T. Beritic. 1971. Profesionalna akroosteoliza. Arhiv. Htg. Rada 22: 53. W. A. Cook, W. M. Whitehouse, H. J. Magnuson & TH. Dp- _Occupational acroosteolysis. I. An epidemiological study. Arch. Environ. HBMLH2:61. Dodson, V. Nv^sD. Dinman, W. M. Whitehouse, A. N. M. Nash A H. J. Magnuson. 197rffitocupational acroosteolysis. HI. A clinical study. Arch. En viron. Health 22: 83i^ms. Domininghaus, H. 1972^WBDststoffe I. Aufbau und Eigenschaften-Kunststo/f- sorten-Anwendungen. 2nd4flh^DI-Veriag. Dilsseldorf,West Germany. Domininohaus, H. 1973. KunwMte IT. Aufbereiten-0berflSehenveredein- Uny formen. 2nd edit VDI-Verlag. Dlmldorf, West Germany. Dublin_L. I. & R. J. Vane. 1933. ational hazards and diagnostic signs. U. S. Department of Labor, Bureau o^Bhpr Statistics. Bulletin No. 582. U.S. -- . fit**1 In DimiBr, \/ 47 602454 BFG35892 Thank you for choosing Advanced Information Consultants VMar for your document delivery needs CMt $ MI Mail GEO02 Tram lypm 6 $ WMowiwi--------- Ua*rf $$ | vapor pressure of vinyl bromide, there should be problem from ingestion incidental to industrial Single prolonged exposures may cause slight ane$ thesia. Repeated inhalation experience indicates vinyl bromide is not highly toxic but overexposm! may cause liver and kidney damage. A level of50 ppij may be used for control purposes until a threshold^ limit value is recommended. Undiluted vinyl bromide is slightly-to-moderately irritating to the eye. Direct contact with the liquid capable of producing slight-to-moderate conjunctiviti which subsides in a day. Since rapid evaporation the liquid can cause a frostbite-type injury, eye e: sure may result in a bum depending on the extent oi exposure. Undiluted vinyl bromide is nonirritating to the i tact or abraded skin if exposure is not excessive. B^? cause of the rapid evaporation, frostbite-type inju can occur if exposure is excessive. Treatment: In case of inhalation exposure, remove! individual to fresh air. If breathing has stopped, si artificial respiration immediately. If eyes are contain^ nated with vinyl bromide, they should be flush' immediately with copious amounts of flowing for at least 15 minutes. VINYL CHLORIDE (Chloroethylene; Chlorethene) Pure vinyl chloride is a colorless gas at room ten perature; its boiling point is 13.9C. It has a sweetish odor. The vapor has little or no irritating effect Su human subjects exposed to 4000 ppm for 5 minut reported no effects; 12,000 ppm under the same cohcj tions caused dizziness in two subjects, but no apparent difference in the reactions of the other four subje Two men exposed for approximately 3 minutes# 25,000 ppm experienced dizziness and disorientatjo as to space and the size of surrounding objects,' complained of a burning sensation in die soles ofti feet Atmospheric exposure to 10% vinyl chloride pj duced deep narcosis in mice and rats, but no de 30% concentrations killed these animals. Expos guinea pigs to 20 % produced deep narcosis; but 1 of five guinea pigs survived exposures to 40 % coned tration. The principal pathological changes in anil dying from exposure were cong ,vith pulmonary edema and heme don ofthe liver and kidneys. Thirty-one cases of hand disc ported among 3000 workers invob manufacturing and polymerizatio plained of soreness and tenderm The great majority were character factors: symptoms likened to the naud's phenomenon and acroost phalanges. A few had no symptorr genographic evidence of acrooste die patients, there were external dorsal surfaces of the hands and fc like appearance resembling chan in scleroderma. Some had clubbir disorder is believed to have resul nation of physical injury, chemi sonal idiosyncrasy [R. H. Wilson t (1967)]. VINYIPYRROUDONE Vinylpyrrolidone is a clear liqu ble with water and having a boi (400 mm Hg). The acute oral toxi lows: LDo, 1.0 ml/kg; LDS, 1.1 ml/kg. Skin tests indicate that this sensitizer nor a primary skin irrita Treatment: In case of contact wi immediately with plenty ofwater. VITAMIN A (Oleovitamin A) Vitamin A deficiency leads changes of the cornea, iris and len growth in children, and changes ii ^ Hypervitaminosis A is charact irritability, pruritus, headache, cr oflips, diplopia, and low-grade fe toms that usually appear later in> tkm of the skin (carotenemia), l Bent of the liver, and swelling an of the long bones. Severe gastro experienced by arctic explorers s) polar bear liver. One pound of thi: 1,000,000 IU of vitamin A. Acute 620 BFG35894 24865003 vinyl bromide, there should be no, ;stion incidental to industrial use-1 exposures may cause slight anes-L lhalation experience indicates that> rot highly toxic but overexposure 1 kidney damage. A level of50 ppm : control purposes until a threshold : unended. bromide is slightly-to-moderatelyK e. Direct contact with the liquid ijS ngslight-to-moderate conjunctivitis a day. Since rapid evaporation ofa ie a frostbite-type injury, eye expov a bum depending on the extent of bromide is nonirritating to the in ti n if exposure is not excessive. Be*f l evaporation, frostbite-type injuiy' re is excessive. .$ lse of inhalation exposure, remove, air. If breathing has stopped, start's n immediately. If eyes are contami-jg bromide, they should be flushed^ ous amounts of flowing water] tba. iloroothyiem; Chlorethene) ide is a colorless gas at room tencPS g point is I3.9C. It has a sweetishT as little or no irritating effect Six] .-posed to 4000 ppm for 5 minut ; 12,000 ppm under the same cone ess in two subjects, but no apparent eactions of the other four subje i for approximately 3 minutesenced dizziness and disorientation] e size of surrounding objects, aha] liming sensation in the soles of 1 xisure to 10% vinyl chloride progj ;is in mice and rats, but no deaths;! s killed these animals. Exposure ofj > produced deep narcosis; but threg| survived exposures to 40 % cone pal pathological changes in; dying from exposure were congestion of the lungs vdth pulmonary edema and hemorrhages and conges tion of the liver and kidneys. Thirty-one cases of hand disorder have been re ported among 3000 workers involved in vinyl chloride manufacturing and polymerization. These men com plained of soreness and tenderness of the fingertips. The great majority were characterized by two common factors: symptoms likened to those ascribed to Ray naud's phenomenon and acroosteolysis of the distal phalanges. A few had no symptoms, but had the roentgenographic evidence of acroosteolysis. In several of die patients, there were external skin lesions on the dorsal surfaces of the hands and forearms, with a rope like appearance resembling changes sometimes seen in scleroderma. Some had clubbing of the fingers. The disorder is believed to have resulted from the combi nation of physical injury, chemical insult, and per sonal idiosyncrasy [R. H. Wilson et al.,JAMA 201,577 (1967)]. VINYIPYRROUDONE Vinylpyrrolidone is a clear liquid completely misci ble with water and having a boiling point of 193C (400 mm Hg). The acute oral toxicity for rats is as fol lows: LDo, 1.0 ml/kg; LDjo, 1-5 ml/kg; LD10o, 2.5 ml/kg. Skin tests indicate that this material is neither a sensitizer nor a primary skin irritant Treatment: In case ofcontact with skin or eyes, flush immediately with plenty ofwater. VITAMIN A (Oleovitamin A) Vitamin A deficiency leads to night blindness, changes ofthe cornea, iris and lens, keratosis, reduced growth in children, and changes in tooth structure. Hypervitaminosis A is characterized by anorexia, irritability, pruritus, headache, cracking and bleeding oflips, diplopia, and low-grade fever. Signs and symp toms that usually appear later include yellow colora tion of the skin (carotenemia), loss of hair, enlarge ment of the liver, and swelling and pain over the ends of the long bones. Severe gastroenteric upsets were experienced by arctic explorers shortly after ingesting polar bear liver. One pound ofthis liver contains about 1,000,000 IU of vitamin A. Acute poisoning may occur 621 BFG35895