Document rxdLmawY5dQBvxgr7vrG9vrvv

n*i |j... is. i*n| TcmcoLOcr IH4S-I14M CNVinONUrKTAt. AND INDUSTRIAL TOXICOLOCT W I'm: Mnlk - Ornpltlmit Hrillh, R|41|I|<A Nfillh t |li. JO.TJ. R. D. fplurm. t>l_ I.C.I. Ud_ AUtrNj Rr*. Uirclrifl'ld. C*r*Mre, tnrL, t/KJ, 0. T. COMM(NS and A. A. CFRNK* Slim kM am IwN w 1/aAn taat LANCET (NORTH AM ED) *2(7772): J05-33J. 1972.--Amen* lo Uv 4rltr> mcu bld*ki4 vsi 2ft*7 itc/lOO ml* IWw *)) m difference of atatiitteal iipuficaftc* to to* bifrid'intli of tmofccrj and iKxitneUrf, mr to* b*wi-lci4j of AJchf-ofctft Ad dav-aMft driver*. Carbnxvhrmnelobln lewis el smoker* vtrt itoilflrull^ higher than Uioie of neei-smoker*. and Che level* *in ilpUkanllj blcKer in 4if driver* Chan to night driver*, | 1144ft. MC WTWE, MATILDA 5. and CAROL R, ANCLT* (Dtp. Prdlalr,, Uftlv.Nebr. CMI. Med*. Omaha. Kebr, 6*1C5, USAJ Air Iradt RrLitt.*n to )r;*5 In blwl rf Mack ftrHnol cMI^rrn *?_ ch>r*y,,ft*ph`<v>ph^te ohrrtr|v:cin:><r. SCIFhCE Qa'aSH) 177/4046); ijo-iil, Dlu*, 13?2,--lilack irhitercn (44) at 2 elementary *chool* within (1.1 mi of a battery plant had aloiifieaMJy htrher (P<0,01) cmceatrabcws of Pb in their bloods (34,1 * 6*7, mean + ED) than 122 student* (264 * 1,1) at 7 schools 1*3 ml distant; S mo. later there was a comparable dtfferroee between red cel) Pb valve* ($44 * ll.ln.3M * 124). Amooc the blacks, thee* deficient to ghicaac-'^^hosphate'ilehydrftCmate had a higher (P<J0O5) eenceatr*- Uen of Pb in the blood after correction for anemia 02,9 * l*.7) than the soodeflctmt (25.7 ^ 14), and a hteher concentration to *he red cells (474 24.7 as coniparwd to 354 * 15,1 P<*00)); the tnsyme effect was mdepeodeat cl geographic location, t 11447. MARKOWITZ, SAUL S,, CHARlXS J, MC DONALD (Roger William* Geo. B25 Chalk-Stone Avt-, Providence, ft. I. 0290ft, USAJ. WILLIAM H-THEAE and MARVIN 5, KFRZNTR. OecuoMlnnal arTT^steolv>ltt ARCH DERMATOL 106(2): 219-222. mu*. 1572.-- Occupational acrmctcnlyfU i> an unusual disease to which affected persons have sclerodermnid-tik* lesions of the skin, conditions similar to Raynaud's phenomenon, and asymptomatic, bony selects of the extremities. Evidently, the disease is confined solely to worker* to toe plasties industry, specifically those engaged to the production of polyvinyl chloride from vinyl chloride. The Incidence of the disease is anknown tut is thou^r to occur to 3^ or less of workers, | mtt. TCLSSK, D.;. (Ftoh.JUs.Ec=r*,Ci-.21c!,S*=,2i. Andre***, N. B., Can.) Ar.it** t-vne;-/ H r"ivr*xvrihvfne eH-rs and P0*T0weth7lcne ether* to 5. kj Lit ii;d C, oce-viirui, WATER KE5 mn55^762. llius. 37*2.--P olyoxyrthy tone ethers are more toxic to aquabc faana than polyoxyethylene esters, pnlyoxvethvlene (4) lauryl ether is 9 times more toxic than polyoxyethylene (14) monoliurate at the ILL (incipient lethal levels) to Satoio solar and 14,000 times more towc at toe 9u*hr LC50 {lethal concentration median] to Gammarm occanleus Scrgestralt. t 11449, HOFMANN, A. (tost* Toxlkol., E, Merck Darmstadt, D-6160 Darmstadt 2, West Ger.) and M, .STUFF LDfc`R. TicrexperlmentaU* ttatersuchunpcn pur tewrtctoxUcnlcictaehen fv-ujvilung ven 2-ehloractfiyUsocyanat. (An investlratinn nf 2-chlorocthyl isnevamte in laboratory animal* wuf^re-.ird In toe tmijUrahm* as T'r^ennal occupaiK*ul h.ir.idll AiiCH 1v<MKOL 2J{1): 73-44, lliua." l972,'ffn(:i. svmnj.}-*7he acuto oral toxicity of 2-chtoroctoyl isocyaa* ate (CAIC) to 296 tngAft lor male rats and 630 mc/Vg for ftmale mica* The extremely small cuanbty of 3 ul CAIC caused severe irritobon m Q>e eyes of rabbits, particularly of the conjunctiva. The ekto wo# also affected ccmsiderably. tohabtlon experiments, tovolwif a new version cf a proven method for pen^ratiac air-vapor niutures, pro duced so evidence of aystemie toxicity, but iut CAIC be classified as as Irritant vapor to the respiratory tract. Tne LCsnfor ruts to i4 ppm aftor exposure for ft hr, while rate In 2 experiments tnvohdof lO^lay expoum to vapor cu-irmtraoons ^ 9.1 and 34 Pfnn, respec tively, survived. Alter a fortmtyit's withdrawal following each exiten* toeftt, blstolocicaJ examinatueis showed traeheotironchlbs and bronCftopmraaui but so pathotocical chanre in any other organ taamlned* A threshold Ustt vahie (TLV) of 0.02 ppm was suggested. t 11450. JCSE. FRANCISCO It. (Dep. Phyeiol. Mvg. Nutr^ Uftiv* Philipp., Manila, PfclUp*j,l A study of |es* M-.ird in suwc f-sd proeesstoc todusbrivs. ACTA MED nilLliT aU): 4d-Viriv*2,--'Two but tery pUntii, i oauil e'taMioHnirnta and 1 company manu/actuiing lesd wxjd* were saidied to exjhiaie tne vsteni and ia^adiu of I'b hazard. Methods of evahijtloa used *rre levels of 1*0 to air, and urinary rb, stippled red cell count and runiral manifesuttons sugrestire of Pb lalMtstie among emptryvee to the establishments, imtb of Pb to air, Pb cuicenirJflAn in the urine and slipplrd red cell count mn nicher to the lead ertde and bstlery pUnu than In ch,ve eticafed to paint manufaemrtoft. Clinical eiamJestatiens ousaeettve of Tb psfoilit were she more fmywent, Oood rorwiaticm wms pbaervwd betww^a toe takwratory findings and the Clinical manlfestaticnn Indies* tan d mtkf Fb potsmlng. f 11451, COOOWIN, dOtfN W. (Day, Hwnwruiaw, bwta tm# 9Ur Dr?,, Tesarttosa, Tea. 75901. USA.) Twenty yeyi iwsiiv TNT * a sh*tl budtog plant. AM ISO IITC AftnOC J 33nl 1|-s't. ||tus, IfiTl.--In tie handling 4 TNT wthn the murntt*^* uutusirv. soman oxjwtsvre to (Ms evtKfsnce cannot be cnmplnieie avntrtrd. The mat Of a Prevtollve Mf4ir.ll 1`rflcnm is is prevent urh exfe.wjf-s fr*en canine any permanent damsc* to worker*. Fihwnl v*ttiu(i<u wito wet scrubbers, * nf protective clothing, mand-itnrv praetire of pmd penonal hygime, and careful medical *wpervt*tv have e*nbned to ccempltoh this goal. The se of the Thymol Tbriadiiy Teel m eweh t proCram was n valuable indicator tf liver malfunrti*ei. * 11452. KJIAMFR, C. C* (Dow Chem. Co^ Midland, Mtrh. 4*ft40. USAJ aM J, E,MU7CM1F9, The mrrclto*o *4 elmirxl and ewvireei- menta) mcseirfisrAts for worr-y^To-Minx-d in vinyl AM IND HYC ASSOC J Ulll; I'-O'J. 111... 107;.*-A ir.ru..-> .. c^.cnbr* for the statistical consolidabtsi and correlation nf envir<sim-r.tal ineasuremetits and clinical ftadtaev ustnc ax an example a group of healthy male worker* exposed roittaety to vinyl chloride for o*riod up to 25 yr. Retroxpectiv* to oxture the study reveals several stabs* tlcaUy alcnUicant effects from chronic exposures to vihy) chloride and traces nf vtnytidene chloride, 11453, EL-DAKHAKHNV, ABDEL-ARlZ and YASSIN M.FL-5ADDC. (Dep.Occup. Health, High tost. Ihibllc Health, Alexandria Unv,, Akxandrta, UARJ Lead to hnir mwt exposed worker*. AM WD WTO ASSOC J 33(1); 3I-i4.rn.l-ifI7-*la , .ludr pcrtsrmr. at 17 Pb exposed workers, i correlation m found between levels of Pb in hair and the biochemical and clinical landing*, A Pb kvet an hair of more than 30 u%Jt could be coAS*.1erwd aa a atpa of extessrv* Pb level, t 11454, LAUWERYS, R, DELDROCCK and M, D. YENS. (Unite Toxicol, Pathol, Travail, Catholle Umv, Louvain. Are. ChapcUe-auc Champs 4, 1200 Bruxaels, Bclg.) Autonatod anatyM* of <K-lto*amint>- Lievultolc acid in urine. CLCV CHL'4 *CTA 40(2); 443-44 7* fihw ~ 1972*--Tie additton'ol an inlsmal stai Jxrd of ft-aminolcvuLmr ectd to the urc aliows the colorimetric leicrmlnaoon of this metabolite without toe need of a preliminary chromatographic sepamaon. The speed and accuracy make the procedure suitable for toe periodic ccnlrol of workers exposed to Pb* ` 11455. M0CS1C, J, ana 5. RUKOVtC. (Inst, Fannskol, TikslkdU Med. fL, Sarajevo, YurosfJ t/iroci i.xstafania kronicnog opstruktavnog bronhltlma U radnika erne metalumje* [Causes of chronic MretnieUve bronrhius In (frwpn melalluriw wnrler^.l AlOf IliC- F-\T>^A lljhSiKOL'' 2A);"V*3L kin. XviijreCii. l<2u icnftl* summ.j--ah analyst* wan performed on 420 people working and Uvyi* under differ ent conditions of exoosure to air politic*. Respiratory symptoms vert questioned and the ventilation funrtioo of the lunci, 6^ and COj content of arterial blood, presence of altcrpir phenomena, oata on smokinc habits and the consequences to pulmonary and cardiovascular systems were studied. The ft metal Iona that constituted the dust were investigated. Experiments wore also performed on frogs (Ran* ndibunda),--J, F. L, 11456, CONCHAntJK, . l,, A. A* POLYANSKII, 1.1. SHVAtKO and A* A, CHDC1N* (Dcp, Public Kiev Med* Inst*. Kiev. USSRj Facovyc Umcoehiya funktsil shchuovidnol zhelexy krys pn khronicheskom vozdciacvli dibromantina, [Ph.xs- alter.ifc-ny "* thyroid function toi ra*s_exrmxed to to* chrome activity Y dtbr^nT j;;Tn.l l^fG SaNIT 5u(lt/)r JtM-t09, (ifus. I97i[recd, 1972{.--The funcimnal ccoditloa of the thyroid va* studied m rat* wxth 1-131 aftor dnnfcmg HyO with dibromanthin concentrations close to those fmrnd in swimming pools disinfected with this chemical, to the 1st me, there was mm citation of thyroid function, to a 4 mo, experiment, tom latter effect was replaced at later periods by pronounced laftibiticn, Harmful effects on humana are not certain*--N, L. C, 11457* FROLOVA, A, D, (fliJIif Wifftid* of Xtudwlnr bi^cranafnrma* tlon of prison* to orpanlxma.l PUAC LbK~ 24|2/4f:~6J-*w 1972, [CiA.cn, and tngl. wuu^ The mechanism of toe toxic effect of Industrial poisons wax discussed. TTie lack of methods tor mcntUieation of chemical substances and products of toetr transformation in biolocle material, made these studies rather difficult. Simple methodic approach aifordme indirect assessment of the late of fnrvui *'ibstxoccs to toe orranlxm had not yet tost Itv imoortuice. The e(lectiv^n*ss of proposed simple procedures tor studies of the fate of pqi*m was demonstrated with 3 repretenubve* from the series of lluurated compounds.--J. A. L. 1145ft* rCTItOVA-BEnCCROVA, VEIU (Reprints: Vera Fiaerww* Oergerova lbomse, 14$&E. 25A Hoad. MUml, fTa.33t29t USAJ nod J, LUOVnC CFTTL. Efektrtcky mnrfe| pro vstrebawii meiatoli*-> tows a vyhicevanl bentenu u ctoeeka. fr Metric rnndet fnr Ue ahsortmon toetsN>H*_m_ind eagtytli cf tworene in man.) TRAC UK 54(3/3): ta-40. 1Um,1S12.[|iiim, and | nxl, eumm.)**TTie vahies for the resistance and capacitive in the Metrical aoate^we wow dertwd by analogy to phyeiologtcol factora for o 70 kilo mao (blood flow in aaom nexo u / u-tL a