Document rxQ2LGnJNXVLQ3L0k33O3JeZ0

*mjt .1 *r; *t*f H* TO October 13, R. Marotta R. L. Lias . -- Dr. W. H. Hunt - Medical Department At*ached is un App'ioatioh for Toxicity Study describing an e'.porunGntal silica product for which test marketing is planned in November of thi year. As indicated, this matciial, 'whirl, will be identified as MAROCEL A, is a physical blend of a purifi *d asbestos fiber and SAN'TOCEL Z. Please adiis'c whether a'toxieity study should be made with regard to in-p.'ant and customer handling. If not, please provide us with a statement wliich wr' ran use w>th our labor force in Everett as well a>, with customers. Thank you f.n you'" assistant e. / tl Altai hment Ha rrv T eit her 6113--024069 .,' ^-rVt i `-V-if, 't- aaaaiaiii ':'vfVV - -* *' 'r.i-t .. AF ! LTC'~TCA *v *. a ytqt't; Name of CompounJ: I/I Ilb-nd of S.:::to<. el / U Open Aslu-stos Fiber Date: 10/13/67 Hc-J . Dept, Monsanto Kar.e : MAROCK K A Project "o:_ Type ol` Cor.poun i ( ineccMci te, pi-istielser, etc .) : Thickenir.n Ag.-nt PHYSICAL PROPERTIED *0rn- Fine powder .Mcl tin * Po.`. nt r Vapor . P.'crcure : Dustlnecc Yes _Eci 1 in-^pcir.t or H-n*e: CHEMICAL PROPERTIED 1. Purity { expected impuri ties } : M-:* 'Oil), Si4O10 Stabiiity: SolubilttlAA' la : or r-'t - .r'.. 6. ?-7. 5 in aq. slurry Water:- Insoluble.- ' ' " Organic Solvents: insoluble Voce table 01.1c: Insoluble Minor-;:! Oil: : Insoluble Alcoriol PROSPECTIVE ;:SE: (r.oi.-.o i : bar. ., ,'-;r -era rt n uco>i, or :.) Prodm t will In used indu.st rla 11 v by addition i>> various liquid polyester and other resin systems. METHOD ADD HAZARDS OF KA'ICEA CISEE Asbestos fiber win bi* blended with SAT. IOCEI. /. iri a loser1 blerdini; svs*em. EXPECTED EXPOSURE-. rinsing HISTORY OF EFFECTS HOT ED J.\ EAI<. A TORY OF rR-'I-TCTIOr* - Non** LITERATURE REFErtENC:',.' S<*o in *! ,I*nitn f* ir!:f!r iifrr.tt'.ir**. Urgency of Fro.br ;f lest m.ir-.-'.,- s. bedded m November ! 7. Remark?: Sanedos .an be provider! bv H. , ti-r or K. M.irott.i U.v>i. C. 2?: o V..> >C.% :.:a i. : PP- "C:: - >v ;.v It has hen know:-. f :>: r v.-y ye.'.:s ih..'.t so:..a pcr'.ar.s vorktr.3 in asbestos prob.etio.'. ware to b:vd.., a dix.-.blir.; iur.,; disease. In Lio.\ bee. Lr.jvr. n :> .. : -1- tc t r.r.c w, ..lior.j 0: 0 he-.ro; d--; t. ..'it;, iurth--: ...Id work v..h r. ;e. .. withe.t bevel '.trior.s- wtr. kept be 1 r. Certain love . It is now Cn- th-.t a m.r.r. car. work c - 3-hour week "o c. : ir.o without developing csbaotoa.o it the ci'-a^teT b.st particle count is kept at or below 1 m.ill-icr.'particl-.o par cubic root ci air. This dust concentration or 5 tui iii'or. :particles car cubcc ice. ci cir ic the 7hri.rr.olo Lim.it Value for ricnos, and r.o cocas** r-.` acker 10. i; ore hr. run to hero occurred when ex-josuros 'hove beer, "a in: hi .`.ad a; or below this ibval, despite larj-ar scale utilita.ior. (now app.-aack.tf.j or.J mil.or. tons per year in 'he L.S.A.). This ccr.oer.tradcr. ci cu.it ic 3ur.jr0.lly r..t visible in aha average work area unless a beer, ci li^k.t cieaarv a'Tyr.d.ll eiiact as prase.-.t. Usually the dust concentration r.aoo ba ircr- i --10 cal lie-, particles per cubic foot before its p r _ s e r.c. a is visible or. arctaje li^'r.tir.J ccr.di tior.s . Several years c_o. it v_s reported that ak.-ra w..s or. increase in the incidento,o.i c.k.aerous t.c.oro, copedally c: to; lur.3, associated with asbescoo.:.. ".cccr.-ly there b._n reports ci cc-.a cancers occurring ir. individuals exposeu to a.castas d _ s t, b.t who ho-.--; bivdvsad clinical asbestc-is. 1: io beliavea by r.aot --ttr.or.tles h.1 a:...as rave bear. as.cciated with o>:...orure . si j-.trsear.dy e.-;:? Tores.no..i Ltm.it Value. A major n. ...viaedr.r a: , .uo-to a prod.tt.. :..r..;s asbestos has not be.-a -hi-a to shew -n ..-.or-.: .'"in cancer.a: 30.. :.ran working where d.st aer.aar.trat.on-: v_.a .-.:r.t.ir.ad -i the Tnr-sr.l Lt-it VaLue. Control control -itk.-.ba or. -n-a"Lp;:li.-..ble to a v.:r: :/ c.' dusty oparct i t.'.s. They tr.o luaa clr-oa-d flew ;t- wtt processes where possible, and ade.._a: ::<ke----- v.nd.adn-. -her : ;a n i n ;rhe system, -re tiecess-: -- . -a .d j u. - - C ., , . ^ c w..O . -- ..l. .. .... narcoter- istics of o.-.er-it. da:f m--.. rt. 1 ;. "-..re scd-> factory ccr.tair.-ar.t to stay within ..-.a Tore .-.'-old L.-.t '-"a..: .s my r.cdaal or t.-psss: 1 le, efficient and raid'd. respir-tr-.; ar: avail.-de ier tr.e roteo t to - of tha ermloyee. A progra... of er.v tr: -.manta . tor.-, j .. h.tj.-.ly de;tr-ole to -:e te mine that Tore she . _ L.r.. . "..'.a.s ara r.. . '___ ^...d. In nape- r.o.-.efaa turir.5. it would -a b-dr-bl: 1. - a.-.l .rnn.a..tr.t 1w .-re the asbestos is dumped from, bag; into a pul;. . lurr . 7 r.: ..-nt rat. a - s should also be detern.r.td where . . ,, - , t.turs tr t mi--.king nr___ at... 'hr.t'.e initial dust determ..nation , skidd s : '.t ::: --.r.t tn-t. r .-a 1;, ante the level has beer, est.blt.hod as satt-.f__t-ry, the fry-.ncy m.r.y h extended to occasional teats tt a.sure -cr.c.r._at .far. at .1 sat..factory condition. - -j , ._i .,,--- \i _ . ...... . . . -. - 7-- hy. 1 . / --Hr Ai--i . ' ~ liii 1 -2- Pr c~o. .p 1 C`y s.enc nod pl'. r r c pi.y i ici ^ ox i".'.ir.'.7 7ur.j or * to r .ee r s Jrc desirable. These should rnciude c:.tJ: X-r-ys to insure th-t the -o;.:;: has no cheat co.rJrtrcr. prior .o work vita ; ; ar.J to determine that no lung charges are ror-lti:..., :r:..- -irk vith asr. - tc.s . It is believer that the addrrrcr cf usb. tos at the proper 7 c levels during the r..nu:ac.ure o: payer products vo.la he h.rr.iess to the consumer. Total c!a-.tin; vould have to be veil ir. excess c: ar.y levels acceptable to the cc:._ur...'r tor the a..bes;a-. concentration tc approach the Threshe id ! ir r . 7aiue. In cor.riu..tor., vatic a-.'-.e.-.: as dust ir. e:.eess of the Threshold Licit Value is potentially har...:ul, as are a ar.y orhc- dusts encountered in industry, it is as re-drly centra, led as other such dusts ar.J it can be usac safely vith apprepri-te precautions. Car! U. Derr.ehl, M. D. Director or Toxicology W*M~ K. S. Lane, M. D. Assistant Director o' Tcxico.ogy m October \9, l?r>7 TdfCCTL A K-.r t,. rn - F':AiO - pi.iss Mr. Marry Toichor HTEIC I would l*-'? the following type varr ui_y stalci'flnts for our customers to vno*> w aro detnilin<-> sehj'-ct compound. "I'arOL-cl A is a phynieal blend of a puT-i.fi od asbestos fiber and a colloidal silica povriar. Asbestos dust control is quite necessary. These methods include enclosed flow syators, w>t processes, and adequate cxhatist ventilation where openings in the system are necosuary. Tor tc-porary or internitteut operations in wnich * wtin<7 occurs, dust respirators approved by the li.S. Bureau of Mines nuit used. 'The threshold limit value for iobestos duut particles is five nillion particles per cubic foot of air. This is a relatively sncll amount ant! if noticeable dust is present the level is hiohor than the abevc slated value. ' You can edit the doneription of the productn any way you wan I dc not believe any toxicity worh in necessary.