Document rxN7vByyX9NY3z60Zam09bxQG
Huntingdon Life Sciences Reproduction Study______
Footnote:
96-4080
Estrous Stages Preface
Page 1 Draft Final Report
Appendix G
aP2 Generation animals were not smeared on estrous evaluation Day 12 due to technician error.
BFG44056
BFG 002891
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Huntingdon Life Sciences 96-4O0DB REPRODUCTION STUDY
APPENDIX G
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
P2 GENERATION
GROUP III - 100 PPM
ESTROUS STAGES
FEMALE#
DAY OF ESTROUS EVALUATION 1 2 3 4 5 6 7 8 9 10 11 12al3 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
3531 3532 3533 3534 3535 3536 3537 353B 3539 3541 3543 3545
3547
3549
3550
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PAGE 11
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Huntingdon Life Sciences 96-408Q REPRODUCTION STUDY
APPENDIX G
PAGE 3
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
PI GENERATION
GROUP II - 10 PPM
ESTROUS STAGES
FEMALE#
DAY OF ESTROUS EVALUATION 1 2 3 4 5 6 7 B 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38
2501 2502 2503 2504
2505 2506 2507 2508 2509 2510 2511 2512 2513 2514
2515
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Huntingdon Life Sciences 96-4080B REPRODUCTION STUDY
APPENDIX G
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
P2 GENERATION
GROUP I - 0 PPM
ESTROUS STAGES
FEMALE#
DAY OP ESTROUS EVALUATION 1 2 3 4 S 6 7 S 9 10 11 12* 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
1531 1533 1535 1537 1538 1539 1540 1S41 1542 1543 1545 1547 154 9 1551 1553
D DDE DDDE DDD E DD EE DDD SD D DDDDE EMD DD E DE DDD EDD D ED D E DE DDED PED EDDDB EDD eED EEDDDEDD BED DE DDDEDD EED E DDPE DDD EDD DDDEDDDED0D EDDDE EDDDDD E E DD E EDDEDD EDDDE DDE ED D DDDPE DDD BDD DDP EDDPEDDE
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PAGE 9
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Huntingdon Life Sciences 96-4080 REPRODUCTION STUDY
APPENDIX G
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
PI GENERATION
GROUP IV - 1100 PPM
ESTROUS STAGES
FEMALES
DAY OF ESTROUS EVALUATION 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26
4501 4502 4503 4504
4505 4506 4507 450B 4509
4510 4511 4512 4513 4514 4515
D D D E E D DD E MD D P E M DD E E D D DS EDDE EDDDEDDDEDDP ED D DEDD PS E DDEDD D E B D D EDD E E M D D E D D DC DDPEE DDDDDDEMD DDE EE EEDC D E DDD E MDD EDDEEMDDEDDDBD D PS EDDEEDDDE DD PEM DDE DDDE DD PC P EDDD EMD P EM DED D D P B D DD EDDDS D E DDD E MD D EM DD EMDD E DDDDDDDs MDDEDDDD E DD DEDD DE DDD E DDDC
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APPENDIX G
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
PI GENERATION
GROUP II - 10 PPM
ESTROUS STAGES
FEMALE#
DAY OP ESTROUS EVALUATION 39 40 41 42
2501 2502 2503 2504 2505 2506 2507 2508 2509 2510 2511 2 5 12 2 511 2514 2515
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Huntingdon Life Sciences 96-4080 REPRODUCTION STUDY
APPENOIX G
PAGE 5
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
PI GENERATION
GROUP IV - 1100 PPM
ESTROUS STAGES
FEMALE#
DAY OF ESTROUS EVALUATION 1 2 3 4 5 6 7 e 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38
4501 4502 4503 4504 4505 4506 4S07 4508 4509 4510
4511 4512 4513 4514 4515
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APPENDIX G
PAGE 9
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
P2 GENERATION
GROUP I - 0 PPM
BSTROUS STAGES
FEMALE#
DAY OP ESTROUS EVALUATION 1 2 3 4 5 6 7 6 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38
1531 1533 1535 1537 1538 1539 1540 1541 1542 1543 1545 1547 1549 1551 1553
DDDEDDDE DDD EDDBEDDDEDD DDDD EBMDDD E DE D D D E DD DED D EDED0ED PED E DDDEEDD EED EEDDDEDDEED DEDDDEDDE ED
EDDPEDDD EDD DDDEDDDE DDD EDDD E EDD DDD E E DDE ED 0 EDD EDDDEDDE EDD DDD P E D D D E D D DDPEDDP E DDE
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m=metestrus
p=proestrus
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c=copulatory plug
Huntingdon Life Sciences 96-4060 REPRODUCTION STUDY
APPENDIX G
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS
PI GENERATION
GROUP II - 10 PPM
ESTROUS STAGES
FEMALE#
DAY OF ESTROUS EVALUATION 1 2 3 4 5 6 7 6 9 10 11 12 13 14 15 16 17 16 19 20 21 22 23 24 25 26 27 28 29 30 31 32
2501 2502 2503 2504
2505 2506 2507 2508 2509 2510 2511 2512 2513 2514 2515
DEDDPBDDDEDDDDBD P ED DD E DDDC DBDDBEDDDEDDDD EDD EDDDED DD ES DE EMD DDDD DD D D D DEM D P E DDDS
EDDD B B B BM D P E D D E E DD B DDDC
D E B D D DP BE DD E E B E E D D D P EDD D P S
D D BMDD D D D DD D D D D D E M D D E D D D S DDEMDDPE DDD BD D PDD DD BDDD EDDDDC DDE ED DB ED DDDDDDDDDDDDEDDDC MDPE E D DD E EM DD P EDE E DDDDD DDDDDD D DS DD P EDD D DE D D DE D DDE DDDEDDPC DDPEDDPEDDE EDUPEMDDDDDD EDDPS E E E E E E D 1) D D E E D D E D D D E D D D E E D E E E E E E E DEMDD E EMD D E ED D DDE DD DEEMDD PC D E D D D E D D [) 1) E D D D E E D D D P E D D D D C D D D D E E D L> D D P D D D E E D D D E D D D S
PAGE 3
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Huntingdon Life Sciences 96-4060B REPRODUCTION STUDY
APPENDIX G
VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION
REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS P2 GENERATION
GROUP III - 100 PPM
ESTROUS STAGES
FEMALE#
DAY OF ESTROUS EVALUATION 1 2 3 4 5 6 7 8 9 10 11 12al3 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29
3531 3532 3533 3534 3535 3536 3537 3538 3539
3541 3543
3545 3547
3549
3550
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PAGE 11
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Huntingdon Life Sciences Reproduction Study______
Footnote!
96-4080
Estrous Stages Preface
Page 1 Draft Final Report
Appendix G
aP2 Generation animals were not smeared on estrous evaluation Day 12 due to technician error.
BFG44056
BFG 002891