Document rx6GZv5K1vaXz8Qk7ebq1O16r

} Interotiice Correspondence SN Interoflice Correspondence Subject Fluorochemicals in Blood August 9, 1977 J. D. JJ.. EE.. xRBR... WA3A.... ~.-T$." J, F. A. DD.. GG.. LAZERTE LLOONNGG NPSPRIRCOPOHKPKEOOOUPPLEDRTMAN SCHEUERMAN UBEL WWEEIIBBLLEENN 201-1S 236-1 22200--22E 222032160---I318S2E 220-12E 220-2E 22001I--1I8S NECKS % LET197] IBGHELERN FROM: J. W. BELISLE 201-IS Since my letter of July 29, 1977 on the published report of perfluorooctanoic acid in human plasma, we have purchased and received a tape recording of Guy's presentation I quote: "From analysis of the F/NMR spectrum, the fluorine containing part of the compounds in the isolate (from human plasma) parolSodchmoIndtheTESLA, nimmim ae resemble perfluorooctanoic acid. Derivatives of this compound are widely used as surfactants. No toxicological magn $5 elywedsosaciinin,He oustionie studies of these compounds appear to have been published. A complete list of all products in which these compounds are presently being incorporated is not generally available. At least in the past, these have been used in floor waxes, Tn es hae ee og wax paper, leather conditioning agents and fabric conditioning EE EE agents. Two trade names which may come to mind are Scotch Gard and Zepel. Compounds of this nature might be expected to bind to plasma albumin because of their resemblance to fatty acids normally bound." Ea. "Human plasma may contain a number of types of organic fluoro compounds each distinct from the one characterized. We found multiple fluorine containing peaks in silicie acid chromatograms. " t"STThhaatt tthhee mmaajjoorr ppaarrtt ooff oorrggaanniicc fflluuoorriinnee iinn hhuummaann ppllaassmmaa iiss aa widespread environmental contaminant is consistent with our AR findings." J~ W. Belisle /jJz 11114422..00000011 3MMAA11000066772223