Document rwv0xrgymQMQryV2DajLk5Je

FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1948 Apr 2 DOC#: API008 DOCUMENT DESCRIPTION: Meeting Minutes & Attendee List - API Medical Advisory Committee For Information Only - Wot For Publication AMERICAN PETROLEUM INSTITUTE MEDICAL ADVISORY COMMITTEE SEVENTH MEETING Minutes of Meeting April 2, 19W Hotel Statler Boston, Massachusetts CORRECTED P.mAuGxEi jggERS PRESENT w. w. Brooks Kieffer Davis T. M. Frank ifiSOCIATES PRESENT E. W. Adams L. C. Beard, Jr. 5. S. Bonsib GUESTS M. Clinton Philip Drinker ADVISOR D. V. Stroop - API M. N. Newquist - Chairman J. P. Holt - Secretary A. E. Hoag T. J. Kelly E. K. Linder E. P. Luongo R. C. Cole A. E. Dooley H. G. M. Fischer N. J. Gothard J. V. Hamnond R. A. Kehoe R. C. Page Total in Attendance - 30 R. C. Page B. B. Reeve McIver Woody H. P. LankaIma H. R. Warrick H. H. Zuidema A. 0. Seeler N. B. Wilson MEMBERS ABSENT W. 0. Armstrong V. C. Baird F. F. Boys D. M. English H. E. Fraser "W. R. Levis W. A. Morrison H. S. Thomson ASSOCIATES ABSENT C. R. Broun R. S. Driver H. W. Field B. W. Isom A. J. Koewing, Jr. D. W. Larmer C. R. McKay R. B. Roaper G. H. Taber, Jr F. M. Watkins H. D. Wilde API 06941 INTRODUCTION OF GUESTS AND NEW MEMBERS The guests and. new members, Marshall Clinton. J. W. Hammond, H. A. Kehoe, ^ p. Luongo, Robert Collier Page, A. 0. Seeler, and N. B. Wilson, were recognized. t> * Action II MINUTES OF PREVIOUS MEETING The minutes of the previous meeting, November 13, 19^7, were approved as circularized. III REPORT OF SUBCOMMITTEE ON FLUORIDES - DR. A. E. HOAG. CHAIRMAN The report of the Subcostalttee on Fluorides was presented and is given in full in Appendix A. The report of the subcommittee stated that arrangements had been made for the University of Cincinnati to supply to the committee copies of all of their data concerning fluorides. A number of such reports have already been distributed. It was the sense of the meeting that it was desirable to carry out toxicological, studies on Boron Trifluoride; D r . A . E . Hoag will explore the possibilities of having Dr. Robert A. Kehoe carry out such studies and will determine what, if any, additional funds will be necessary to support these studies in the program of research on fluoride that is being sponsored at the University of Cincinnati. Action The committee voted unanimously to receive the report of the Subcommittee on Fluorides. In receiving this report the conmlttee recommended that the API continue to support this program at the University of Cincinnati at the cost of $2,500 for the next year. IV REPORT OF SUBCOMMITTEE ON CUTTING FLUIDS - DR. B. B. REEVE. CHAIRMAN The report of the Subcommittee on Cutting Fluids, with an attachment concerning "Safeguarding the Use of Cutting Fluids and Coolants" prepared by Mr. R. S. Bonslb, was presented and is given in Appendix B. It was the consensus of the meeting that the attached memorandum, entitled "Safeguarding the Use of Cutting Fluids and Coolants," would be distributed by Mr. Stroop to the members and associate members of the Medical Advisory Committee for criticism and for letter ballot as to whether it would or would not be published. If it was voted to publish the report, it would then be referred to the Editorial Committee for final review and then to the API for publication. API 06942 -3- A request from an engineering Journal for permission to publish part . the review, entitled "Dermatitis from Cutting Fluids - A Critical Review," pared by Mr. Bertrand C. Kriete of the Harvard School of Public Health, has jlen received. It was the consensus of the meeting, that in view of the fact *jjat it would be a number of months before Mr. Kriete had modified his paper and utlished it in a Journal such as the Journal of Industrial Hygiene and L xicology, that such a request for publication should not be granted until Kriete had published the paper. Action --* ' 1- The conjnittee unanimously approved the report of the Subcommittee on Cutting Fluids. 2. The committee recommended that the report on "Dermatitis from Cutting Gils," prepared by Mr. Kriete of Harvard, be published in the medical literature os soon as practical. After such publication an extract from the paper will be prepared by the American Petroleum Institute for distribution. V REPORT OF SUBCOMMITTEE ON CARCINOGENICITY - DR. Ms TVER WOODY, CHAIRMAN The report of the Subcommittee on Carcinogenicity was presented by pr. Woody and received by the committee. It is given in Appendix C. In the discussion that followed the presentation of the report, the Importance of the cancer problem was discussed and it was pointed out that government agencies, the medical profession, and the public had in recent years become very interested in this problem. In addition, a confidential memorandum of information for Mr. W. R. Boyd, Jr., President of American Petroleum Institute, describing the available information in the medical literature concerning cancer as related to petroleum, was presented. Dr. Robert A. Kehoe of the University of Cincinnati presented a verbal report of the work that his laboratory had carried out to date on several samples of residual and distillate oils. He stated that a~written report concerning this work would be submitted to the committee within a few weeks. Dr. Kehoe felt it important for the cancer problem to be studied in the petroleum industry by means of animal experimental studies, epidemiological surveys, and chemical and physical studies of various petroleum products. He felt it desirable for a research program such as that outlined in Appendix C to be established. In the oourse of the discussion, the precautionary measures that have been instituted in certain petroleum companies with regard to the handling of high-boiling residual oilB from the catalytic cracking process were discussed. Dr. A. J. Fleming, Assistant Medical Director of the du Pont de Nemours Company, presented a twenty minute talk describing how toxicological problems such as the "Aniline bladder tumor" problem had been handled and is being handled in the chemical industry. Action 1. The consulttee voted unanimously to accept the report of the Subcommittee on Carcinogenicity and the personal and confidential memorandum cited above. API 06943 -k- 2. The committee recommended that: A. The American Petroleum Institute be authorized to establish a comprehensive research project for the development of . fundamental facts, analytical techniques and related information pertaining to cancer-causing compounds which may occur in petroleum or be produced therefrom. B. The American Petroleum Institute be authorized to enter into an agreement vith the Kettering Laboratory of Applied Physiology (College of Medicine, University of Cincinnati) to provide or arrange for necessary facilities and services and conduct the work under a program to be established on a continuing basis by the Medical Advisory Committee subject tc approval by the Safety Committee of the Board of Directors. C. The Safety Committee be authorized to solicit contributions to a special research fund, outside of the API Maintenance Fund, in the amount of $110,000 to meet the costs for the first year which will include $50,000 for non-recurring capital expenditures for construction of extraordinary experimental facilities at the laboratory. D. Responsibility for the continuation of the program of research be delegated to the Safety Committee of the Board of Directors which is hereby authorized to approve and underwrite future annual budgets and to solicit contributions to the special research fund as may be necessary to meet approved budgets. 3> The consaittee recommended that Dr. Robert A. Kehoe and his associates collaborate with the Chairman of the Subcommittee on Carcinogenicity and as many members as is necessary in the preparation of a plan of collecting statistical medical infor mation on cancer in the petroleum industry versus the country at large; end if possible versus other industries. The consaittee alBO recommended that a definite proposal be'made for implementing the collection and coalition of Buch information (every effort should be made to separate any cancers caused by contact vith known products from those arising from other causes). VI REPORT OF SUBCOMMITTEE ON PERMISSIBLE CONCENTRATIONS - DR. T. M. FRANK, ACTING CHAIRMAN The report of the Subcommittee on Permissible Concentrations was presented and was received by the carnalttee. The report, the letter of March 23, 19^6 from Dr. A. 0. Seeler to Mr. D. V. Stroop with an outline for toxicological screening tests as modified by the committee, and the letter of March 10, 19^8 from Professor Drinker to Dr. V. c. Baird describing the progress of th -work at Harvard are given in Appendix D. In the course of the discussion of the outline for toxicological screening tests prepared by Dr. A. 0. Seeler on March 23, it was agreed by the committee and Dr. Seeler that the toxicological screening tests program be oodified as indicated in Appendix D. API 06944 In the discussion of toxicological research that might he carried out equilibrium catalyst, Professor Drinker stated that the estimated cost of a 0l>taileii study would he $15,000 per year for approximately three years. It was consensus of the committee that such a detailed study should not he inaugurated at the present time, hut that a similar program involving intraperitoneal Injection studies he carried out on guinea pigs or other animals. It estimated that the cost of these studies would he less than $1,000. ,ction *----- 1. The report of the subcommittee as presented in Appendix D was adopted hy the committee. 2. The following summarizes the pertinent action taken on this report: A. That the Manufacturing Chemists' Association Medical Advisory Comolttee members he made consulting members of the Subcommittee on Permissible Concentrations of the API Medical Advisory Committee and that they receive copies of tentative and final drafts of toxicological reviews. B. That in cases where a literature search, carried out at Harvard University, reveals that little or no toxicity data are available on certain compounds or products, no toxicological review will he published. Instead of publishing reviews on these materials, a list of such substances with a list of pertinent references will he published hy the API with a statement as to the Inadequacy of the available , information. C. That the toxicological screening teste program given in Appendix D will serve as a general outline for screening tests, but each particular study will have to be modified depending upon the nature and uses of the compound or product. D. That Dr. T. M. Frank, subject to the approval of the American Refining Corporation, submit to Professor Drinker a progress report on the results of studies sponsored by that company on the toxicity of fresh catalyst. After reviewing this infor mation, Professor Drinker and associates will recommend to the committee what, if any, additional work should be carried out on fresh catalyst. 3. It was voted that, in order to carry out the experimental work outlined by the Subcommittee on Permissible Concentrations, $10,000 be allocated from the general fund on balance in the API to be used by the Subcommittee on Permissible Concentrations for toxicological studies indicated above. VII REPORT OF SUBCOMMITTEE OH MEDICAL POLICIES AMD PRACTICES-DR. T. M. FRAME. CHAIRMAN The report of the Subcomnittee on Medical Policies and Practices was presented by Dr. T. M. Frank and consisted of the following recom&endations which vere unanimously approved; API 06945 - 6- 1. That the committee favors the adoption of an international certificate of innoculation and vaccination such as that sponsored by the World Health Organization subject to their simplification from a practical operation point of view in keeping with the suggestions made at the first meeting of the Expert Committee on Quarantine, Geneva, 19^7. 2. That we request Dr. M. N. Newquist and Dr. E. K. Linder to approach the Interim Commission of the World Health Organization to see what can be worked out in line with the above recamnendation. VIII REPORT OF EDITORIAL COMMITTEE - DR. J. P. HOLT. CHAIRMAN The report of the Editorial Committee was presented and is given in full in Appendix E . The committee unanimously approved the report which included the following recommendations: Action 1. That the toxicological reviews on the following compounds that have been approved by the Editorial Committee be published by the API: Acrylonitrile Alkyl Disulfides Alkyl Mercaptans Diethylene Glycol Dowtherm A Kerosine Mercury Methyl Ethyl Ketone Morpholine Naphthenic Acids N-Butyl Para Amino Phenol Phosphorus Pentasulfide Sulfur Dioxide Thiophene and Derivatives 2. That the toxicological publications on the following compounds be deferred until some future date: Acetone Carbon Monoxide Di tertiary Butyl Para Cresol Hydrogen Fluoride Maleio Anhydride Phosphoric Acids Silica Thiophonol and the Aromatic Mercaptans IX COMMONICATION FROM BASIN O'CONNOR The communication from Basil O'Connor to D. V. Stroop of February 2, 19W, requested that the members of the API be informed of the activities of the Fourth International Congresses on Tropical Medicine and Malaria. The desirability of giving financial support to this enterprise was discussed by the conmittee. It was the sense of the meeting that this nottor should be handled by individual members of the committee and it was 3uc jested that they bring this question to the attention of the appropriate individuals in their respective companies. It was felt that no definite action by the committee was required. API 06946 HEW BUSINESS Mr. D. V. Stroop presented to the committee a statement concerning e<pts and disbursements of funds of the API medical research fund, a copy of ^ich is in Appendix F. Mr. Stroop requested that the Chairman of the Medical Advisory Committee ^ the Chairmen of the respective subcommittees meet together prior to the meeting tjie Committee on November 12, 191*8, and arrive at a recQnmendation as to how money the committee will need during the year 191*9. XI NEXT MEETING It was unanimously agreed that the next meeting of the API Medical Advisory Committee would be held on November 12, 191*8 , and the meetings of the subcommittees would be held on November 11, 191*3, in Chicago at the time of the regular API meeting. ' M l Approved: M. N. Newqulst, M.D. Chairman J. P. Holt, M.D. Secretary API 06947 s> Fer Information Only - Net For Publication APPENDIX A REPORT TO THE API MEDICAL ADVISORY COMMITTEE EY THE SUBCOMMITTEE ON FLUORIDES Dr. A. E. Hoag - Chairman April 2, 19W At the Subcoimittee meeting held on November 12, I9V 7, the Report of Subcommittee on Fluorides to the API Medical Advisory Committee was accepted, ^regard to the matter of reports, Dr. H. F. Heyroth of the Kettering Laboratory to supply the Chairman (for distribution to the Subcommittee members) with fncopifiS of reprints of previous publications on their work on Fluorides; also I L supply 10 copies of their next (end first) Annual Report to the "Industrial group*" I* was the sense of the meeting that the Chairman should receive and d istrib u te all reports and technical communications. Dr. A. E. Hoag, Chairman, Subconmittee on Fluorides, is the member of f tbe API Medical Advisory Ccmittee to whom all correspondence concerning the group nroject should be directed. If possible it will be helpful to have copies of such correspondence sent to Dr. L. C. Beard, Jr., as Dr. Hoag's alternate on the subconsiittee. Both are on the staff of Socony-Vacuum Oil Company, Inc., at 26 Broad ly, New York 1*, N.Y. The following roprints were received and sent to the members of the Fluorides Committee: "Fluorides as an Industrial Health Problem" by E. J. Largent; I normal Urinary Fluorine Excretion and the Problem of Mottled Enamel" by Willard F. Machle; "Exposure to Fluorine in Industry" by Willard Machle and E. E. Evans; :The Urinary Fluoride Excretion Among Men. Employed in Alkylation Plants Using the Hydrogen Fluoride Process" by Edward J. Largent; "The Effects of the Inhalation of Hydrogen Fluoride" by Willard Machle, Karl Kitzmiller and E. W. Scott; "Exposure to Fluorides in Magnesium Founding" by E. J. Largent and I. F. Ferneau; "Fluoride Ingestion and Bone Changes in Experimental Animals" by E. J. Largent, Willard Machle and I. F. Ferneau; "The Absorption end Excretion of Fluorides" 41 by Willard Machle, E. W. Scott and E. J. Largent; ''Normal Urinary Fluorine Excretion and the Fluorine Content of Food and Water" by Willard Machle, E. W. Scott and Joseph Treon; "Magnesium Acetate as on Ashing Agent in Fluorine Analysis" by William E. Crutchfield, Jr.; and "Titration of Fluorine in Biological Materials" by Eugene W. Scott and Albert L. Henne. At the beginning of this year we received copies of the "Annual Report on Investigations of the Storage of Fluorides in the Tissues of Human Experimental Subjects and by Dogs, in Relation to the Amounts Ingested by Them." Extra copies vere obtained so that not only members of the Fluorides Committee received them, but all the members of the Medical Advisory Committee, as well. The Monsanto Chemical Company requested membership in the "Industrial Group" sponsoring the Fluoride project at the Kettering Laboratory end were accepted. However, on February 19, 19^8, Monsanto withdrew because they felt that the Btudy of Fluorides on human subjects did not appear to bear on any of their problems. On November 28, 19^7 we received notification from Mr. D. V. Stroop that a check for $2,?00 had been sent to the University of Cincinnati as a contri bution toward the development of information on Fluorine and Fluorine Compounds. I The Committee feels that it can report progress and that the project should 1 continue. This will entail the annual expenditure of $2,500. API 06948 For Information Only - Not For Publication APPENPIX B REPORT TO THE API MEDICAL ADVISORY COMMITTEE BY THE SUBCOMMITTEE ON CUTTING FLUIDS Dr. B. B. Reeve - Chairman April 2, I9U8 At the meeting of the API Medical Advisory Committee in November I9V 7, it was proposed that a bulletin be prepared and put out by the API Medical dvisory Committee on "SAFEGUARDING THE USE OF CUTTING FLUIDS AND COOLANTS." fkis assignment was given to Mr. Roy S. Bonsib, Industrial Hygienist, Standard Cil Company (New Jersey) for preparation. This bulletin has been prepared end has been circulated among the members of the API Medical Advisory Committee and it is now being presented. We feel that Mr. Bonsib has done an excellent Job in preparing this bulletin, and we wish to present it to the API Medical Advisory Committee for its acceptance, subject to change. We also hoped to present at this time the^review on "DERMATITIS IROM CUTTING OILS" which is being prepared by the Harvard University School of Public Health. However, I have been informed by Dr. Albert 0. Seeler, Assistant Professor of Industrial Hygiene, that this work has been delayed and will not be available until a later' date. API 06949 t 'i) - 2- For Inferuption Only - Not For Publication DEAFT As Revised by SubcoTM^ ttoe on Cutting Fluids at Meeting Held In Boston on April 1, 19U8. SAFEGUARDING THE USE OF CUTTING FLUIDS AND COOLANTS April 7, 19U8 API 06950 " J" FRO POSES DRAFT SAFEGUARDING THE USE OF CUTTING FLUIDS AND COOLANTS The tremendous increase in the use of cutting fluids or coolants and the general lack of understanding concerning them among new and partly trained workers suggest that a recapitulation of the hazards involved and the necessary precautionary measures may be of assis tance in safeguarding their use. INTRODUCTION - A cutting fluid does no actual cutting; a grinding compound, grinding; but each vastly improves cutting and grinding operations. Cutting ils are divided into two large groups, the INSOLUBLE and the SOLUBLE, the latter actually representing an emulsion of cutting oil base in water. The soluble -utting oils (emulsions) are used mainly as cooling agents to remove heat generated m the action of the cutting (or milling, grinding, honing, etc.) tool on the work p^ece. They also serve as rust preventives on the finished work and as a means, particularly in grinding operations, for removal and settling of chips. The insoluble cutting compounds, cm the other hand are used as coolants and lubricants, aiding the tools in the cutting operation by reducing friction between the cutting tool and the work piece and reducing the adhesion and friction between the chip and the tool face. They also improve the finish and increase tool or wheel life. Machine tool operators who work with cutting oils and compounds may be troubled with eruptions (rash, pimples, or boils) of the skin of the hands, fore arms and thighs which come in contact with cutting fluids and permit hair follicles of the skin to become plugged with dirt and oil, and cause the condition sometimes referred to as "Cutting Oil Dermatitis." With the exception of certain types of chlorinated-aromatic compounds which some authorities state occasionally produce chloracne, no specific chemical compounds in cutting fluids have been identified as causal agents for oil acne, whose incidence is the highest among the cutting oil dermatoses. CAUSE OF DERMATITIS - As a result of long skin contact with cutting oils, the opening of some of the sebaceous glands may become occluded (plugged). This mechanical blocking prevents escape of the gland secretions, which consequently accumulate, harden and eventually cause local irritation. Infeotion may also play a part, but the germs causing the infection come almost entirely from the workers' own skin, rather than from the oil. More than fifty distinct and different types of harmful bacteria have been found on the arms and hands of the average clean healthy individual. These baoteria are perhaps the most important source of infections, the cutting oil itself acting merely as a carrier of the germs from the surface of the skin where they are quite harmless, into the pores where they germinate and produce pimples, sores and rashes. Cutting fluids of petroleum derivation are sterile and will remain that way if not contaminated from outside sources. Most antiseptics added to cutting fluids in an effort to prevent infections have proven ineffective. Some antiseptics may oorrode the metal being vorked, or may in themselves irritate the skin after prolonged use. If the oil becomes contaminated in use, heat has been found the best means of sterilization. Another cause to which dermatitis may be attributed is the presence of email chips, splinters or particles formed in working metal -- grinding, cutting, polishing -- which accumulate in the cutting fluid and are brought into contact with the skin of the worker, and by their abrasive action may cause slight cuts or scratches affording entrance of germs. These particles of metal readily accumulate on the skin and on cotton waste used by workers to wipe the oil from their arms. Germs present on the skin may enter the scratches caused by this API 06951 3 (Cont'd) -k- ^ e and. lead to Infection. Various devices for extracting these netal P*"*5 les fro oil are on market, but it should he remembered that such alone will not prevent the dermatitis. e*rtract"1 Another contributing factor to dermatitis is the defatting properties of ta such as gasoline, naphthas, etc., used for removal of cutting fluids, 9*v?tln^ in drying and cracking of the skin. Dry skins and senile skins are most r<?3Uiy t0 i,e affected in this manner because the skin glands are not sufficiently l^eve replace the fat extracted from the skin by the solvents. Defatting of *C skin is often times further aggravated by the use of abrasive or highly ^Lline soaps. Even bleaching powder sometimes is used to clean up after work. that are naturally dry will not stand such cleaners without at least becoming Griped or fissured. These cleaners also abrade the skin, irritate it and reduce t0Preaistivity to dermatitis and infection. Constituents of cutting fluids other than the mineral oil may also play a art in promoting skin irritations. Certain chlorine compounds used in cutting P<ls may irritate the skin. The phenols, cresols, and other additives are usually not present in sufficient amounts to be primary irritants, but they may act as skin g e n sitite rs to allergic individuals. It should be borne in mind that dermatitis from soluble oils is much less frequent than from non-soluble cutting oils. Soluble cutting oils are more readily and more completely washed from the skin. However, many casos of dermatitis are caused by emulsions. The severity and frequency of the dermatitis depend on individual idiosyncrasy. Oil acne shows a tendency to occur in hirsute (hairy) workers, presumably because of the numerous and well-developed hair follicles. Workers vith fair complexion (blondes) seem to be more susceptible than the dark-skinned type (oil acne is practically absent among negroes). Workers with dry skins are more susceptible than oily individuals. Persons with a previous history of recurring skin eruptions are much more susceptible than those who have no such history. Oil acne may have an increased incidence in summer or hot weather. The primary factor is lack of PERSONAL HYGIZN3. C,lean, experienced work men who do not permit their clothes to become soaked with the spray of cutting fluid or emulsion and who change their clothing frequently are much less likely to be affected. The fundamental cause of the dermatitis is an irritation from the oil. A secondary infection, resulting from bacterial action, may set in if the proper hygienic precautions are neglected. The handling of such cases usually is quite simple. Seriously affected persons should be removed from the exposure, whereupon they usually recover rapidly. TREATMENT FOR DERMATITIS - According to Public Health Reports 6:19^7-53) blackheads, pimples, and boils caused by cutting oils can be successfully treated by cleanliness and antiseptics. Cleanliness consists in a daily change of work clothes and frequent washing of the perts affected. Individuals with blackheads, pimples, or boils should not irritate them by squeezing but should see a physician. It is advisable to remove persons with dermatitis from contact with cutting fluids. For dry, defatted skins an ointment consisting of vegetable or animal fat should be given the worker to rub into his hands before and after work. PREVENTIVE MEASURES - The prevention of dermatitis from cutting fluids or emulsions lies in the adoption of an adequate proper hygienic program; cleanli ness of the person, of the machines, and of the oil. In the latter connection, spitting into cutting fluids or contaminating them with other bodily secretions Is PROHIBITED! Timely dressing of wounds (cuts, scratches, abrasions, etc.) and API 06952 ^pHIiTlX B (C c n fd ) -5- Jfactions and excluding infected workers from the cutting fluids used by others * e aiso important preventive measures. Personal cleanliness involves the formation of a good habit in the worker the provision, on the part of the management, of adequate washing facilities, plenty of warm water, good soap and ample space must be provided for the worker because the regular and thorough removal of films of oil adhering to his skin is worker's first line of defense against infection. Since thorough drying of arms and hands is important, individual towels should bo provided by the jj^jjiagement. Cloth towels are preferred because of their better absorbing qualities, tc insure their cleanliness, proper laundering facilities should be furnished. The towels should be so laundored that all slivers are removed. Approved toilet, powdered, or liquids soaps and cleaners which will not defat or irritate the skin should also be provided and placed in convenient locations in the washroom. A cleaner has been devised which consists of a neutral gulfonated castor oil, to which 2 per cent of a wetting agent is added (Pub. Health pepts. 56:1788-90). The use of kerosinc, gasoline, or other fat solvents and strong soaps should be prohibited for skin cleansing. The Massachusetts Division of occupational Hygiene (Bulletin #259 April 1942) recommends either of those two olxtures for removing cutting oils from the ekinr A - Equal parts of pure liquid or powdered soap and fine hardwood sawdust, free from splinters. B - Equal parts of white cornmeal and this cleaning solution: Sulfonated Noats-Foot Oil 45 parts, light Liquid Petrolatum 45 parts, and Gelatin 10 parts of a 25 per cent Aqueous Solution. Clean work clothes should bo provided and the body and arms should be protected by aprons and sleeves made of impermeable material, such as the new synthetic plastics or elastomers. Detachablo sleeves and aprons in this now material and moro convenient designs arc being made available. Protective clothing must be properly serviced at a central station whore it is returned by the worker at the end of the day. Before reissue to another worker, the equipment should bo repaired, if necessary, and thoroughly cleaned and disinfected. It is suggested that manufacturers' instructions bo obtained and fqllowod for the cleansing and disinfection of clothing and equipment as the makers will know which cleansing methods and solutions will least affect the durability of their products. Guards should be Installed on the machines to prevent splashing or spraying and there should be floor boards to prevent prolonged contact of workers' foot with the oil. A recently developed mist collector, when suspended directly over a machine draws all oil mist up directly from the source to a collector where even the smallest particles of oil ore removed from the air by combination mechanical and electronic filtering processes. The machine should be kept as free from old oil grease, oil and dirt as possible by washing daily. Clean towels should be provided for the worker at his machine and dirty waste used for wiping oil from the hands should be eliminated. In brief, preventive measures are intended to accomplish one purpose; the prevention of prolonged contact between the cutting compound and the worker. Caro of 'the skin; Tho following routine is recoamenioi by the Massachu setts Division of Occupational Hygiene: "(a) Before starting work, wash hands and arms in warm water using a sawdust and liquid soap preparation and dry the skin with an individual cloth towel. Apply a lanolin ointment to replace the natural fat of the skin. An ointment composed of 70 per cent Lanolin, 28 per cont Olive Oil or Castor Oil and API 06953 APPENDIX B (Cont'd) - 6- 2 per cent of a wotting egent (one of the fatty alcohol sulfates) is recommended. . "(b) Before lunch, wash oil and lanolin coating from arms and hands, using one of the cleansing mixtures described above. "(c) Before starting work in the afternoon, wash as in the morning and apply lanolin ointment. "(d) At the end of work day, thoroughly wash oil and lanolin coating from the skin with one of the abovo cleansing mixtures. "(c) Use care in wiping the forearms and hands during the day. "(f) Report promptly to the shop physician or dispensary all cases of skin abrasion, redness, Itching, pimples, or other irritation." Educational Talks By Plant Physician: It is necessary to educate the workers to recognize and report the initial stages of oil acne. Frequent inspection of the employoos is rccommondcd. The physician in charge of the medical service of the plant should give occasional talks to the workers as to the hazards of dermatitis from cutting fluids and make them acquaintod with the methods of prevention. Preplanoment Examinations arc recommended. Workers with acne, dry skins, history of skin disease, liver disorders, alcoholism, or history of previous trouble following exposure to chlorinated aromatics or heavy metals should not be assigned to such work. If an operator i-s known to be allergic or particularly susceptiblo to skin troubles, he should be assigned to other types of work where he will not como in contact with cutting fluids. The United States Public Health Service in 'ts study of cutting oils found that those who developed skin trouble invariably had either a noticeably dry skin or the solutions they were using had a tendency to dry out the natural oil of the skin. Operators with a naturally oily skin did not suffer from this affection. Reconditioning Used Cutting Fluids: The cutting fluid should be changed frequently, at loast every two weeks, and either discarded, or, if it is to be reused, it should be* screened to remove metal particles, and sterilized to remove bacteria. Such sterilization can best bo done by a contral sterilizing system, connected with each of the machines and recirculating the oil, or if this is'not possible, the oil may be removed from each individual machine and carried to the central sterilizing system. Additional antiseptic should not be- added to used or rancid oils. Such a practice increases tho irritating properties of the oil and is not necessary if the oil is filtered and heat sterilized. API 06954 Sterilization of the oils by heat is generally recommended; 1U0F. to l60F. for 3 to ^5 ininutoe eeeme to bo tho usual method. While the destruction of the bacteria may not prevent oil acne, it docs avoid spreading other disease organisms, particularly in soluble cutting oils: and it avoids rancidity and the development of an objectionable odor. The change ana sterilization of the insoluble cutting oils is recommended every 10 days to two weeks, and the soluble cutting oils every two weeks, the machines being thoroughly cleaned with steam and light oil during the change. The use of disinfectants 1b strongly discouraged although a few authors have argued for their use on the grounds that heat irjjrix (''r ilization is only a temporary effect and because the oil contained in the line ^ A i n g to ^roni the sterilizer remains contaminated. Workers should be 10a&ibited from expectorating into the oil, or from contaminating it in any other vtf* Protective Ointments: Since the most frequent type of occupational yjjatitis caused by cutting fluids is pinplos and boils, cleanliness is much important in the prevention of dermatitis than are protective ointments, united States Public Health Service rocommonds that when protective ointments Le used, they should be of the type that will fill the pores of the skin with an innocuous vegetable or animal fat to prevent the entrance of mineral oil. Such a rotectivo ointment should also contain a small percentage of a wetting or falsifying agent such as the fatty alcohol sulphatos, in order to make it easily removable from the skin with water. A small percentage of a harmless preservative, such as sodium perborate, is also desirable in order to prevent fat in the ointment from becoming rancid. Protective ointments which form films soluble in oil are not desirable because the cutting oil washes them off. The sulfonated oils will wash away both types of films. Films will crack when the hands and fingers are flexed and leave areas of tho skin unprotected. Those are tho main requirements of a satisfactory protective ointmentj 1. Easily applied and provide a thin, uniform and invisible film on the skin. 2. Easily removed by soap and water. 3. Non-irritating of itself. k. Insoluble in, or impervious to, the potentially harmful substances it is supposed to exclude. There are many preparations on the market which meet these requirements and the combinations of ingredients are too numerous to list in this bulletin. Omitting special typos to meot particular needs, lanolin is the base of most standard ointments. Lanolin is bland and tends to conserve the natural oils of the skin. Some manufacturers add olive oil or castor oil, especially the lattor, to increase the shedding property of tho ointment and its insolubility in the paraffin series of cutting fluids. -- ^ (The recommendations outlined in this bulletin should be considered of general application; they are of valuo chiofly as a good approach to a specific problem.) API 06955  For Information Only - Not For Publication i APPENDIX C REPORT TO THE API MEDICAL ADVISORY COMMITTEE EY THE SUBCOMMITTEE ON CARCINOGENICITY Dr. Mclver Woody - Chairman April 2, 19t On behalf of the Subcommittee on Carcinogenicity, I recommend to Medical Advisory Committee for transmittal to the Safety Committee of the Board of Directors and for adoption by the Executive Committee of the Board of Directors a resolution authorizing the establishment of a comprehensive research project on cancer-causing hydrocarbons as follows: ? RESOLUTION WHEREAS, in recent months there has beon widespread publication of general statements to the effect that men -working around gasoline, tars, and lubricating oils are exposed to cancercausing compounds; and WHEREAS, such general statements appear to be without foundation but there are correlated results of experimental research work which Indicate the presence of cancer-causing compounds in seme fractions derived from the catalytic processing of petroleum; and there are references in the medical literature to cases of cancer caused by certain petroleum crudes and fractions; and WHEREAS, the situation is such that the Industry is in need of authoritative information on all phases of the subject and that need may best be mot through the establishment of an industry wide research project; NOW, THEREFORE BE~IT ' RESOLVED BY THE EXECUTIVE COMMITTEE' OF THE BOARD OF DIRECTORS THAT: 1. The Institute is authorized to establish a comprehensive research project for the development of fundamental facts, analytical techniques and related information pertaining to cancer-causing compounds which may occur in petroleum or be produced therefrom. 2. The Institute is authorized to enter into an agreement with the Kettering Laboratory of Applied Physiology (College of Medicine, University of Cincinnati) to provide or arrange for necessery facilities and services and conduct the work under a program to be established on a continuing basis by the Medical Advisory Committee subject to approval by the Safety Committee of the Board of Directors. 3. The Safety Committee is authorized tc solicit contributions to a special research fund, outside cf the API Maintenance I Fund, in the amount of $110,000 to meet the costs for the API 06956 (Ccnt'd) - 2- first yeer which will include $50,000 for non-recurring capital expenditures for construction of extraordinary experimental facilities at tho laboratory. k. Responsibility for the continuation of the program of research is delegated to the Safety Committee of the Board of Directors which is hereby authorized to approve and underwrite future annual budgets and to solicit contributions to the special research fund as may be necessary to meet approved budgets. In support of the resolution, I append a confidential subconmittce memorandum II pertaining to the need for this research project. Mclver Woody, M.B. Chairman <1 L API 06957 td d NTIAL MEMORANDUM RE: THE NEED FOR THE PROPOSED RESEARCH PROJECT. jt is well recognized that certain coal tars cause the development of skin er in man. In numerous foreign countries and in several states in this country te is recognized as a compensable disease, thi8 During the past fifty years there have been more than 1,500 cases of skin Cer caused by exposure to shale oils in England. Lavs have been passed requiring such cases to be reported to the government in England. In contrast, few cases 0f akin cancer in the United States have been reported to have been caused by troleum or petroleum products. Actually, about fifty cases of skin cancer caused 51 exposure to petroleum hydrocarbons during the processing of paraffin wax and a fev cases of skin cancer in oil field workers have been reported in the United States. There are more than thirteen states that have laws in effect at the present tune making cancer caused by petroleum products a compensable disease. During the last four or five years various catalytic processes, such as catalytic cracking, have been put into extensive use in the petroleum industry. In the catalytic treatment of oil, relatively large quantities of high-boiling, fractions can be produced. This high-boiling material-has been shown to cause cancer in experimental animals. Animal experimental studies have been carried out in three well-known hospitals and universities on three different samples of this material from three different petroleum companies. All three samples were shown to produce tumors when applied to the Bkin of experimental animals in up to 100 per cent of the animals. These tumors became malignant in most cases. Only a very snail amount of the material is necessary to produce cancer in an experimental animal such as the mouse; for example, 15 milligrams applied to the skin of a mouse once a week for twenty-six weeks produced cancer. Individuals within and outside the petroleum industry, including doctors and chemists who have studied the problem, ere reasonably certain that condensed ring compounds, such as 3> k-benzpyrene and related compounds, known to cause cancer are present in the high-boiling oil fractions from the catalytic cracking operations. It is therefore felt that this oil is"capable^ of causing cancer in man, although no cases in man have been reported to date. It is felt that one of the reasons for thiB is that it generally takes ten or more years of exposure to a carcinogenic material for a cancer to develop in man, and since this oil has only been in production for about four years, the period of exposure to this material has been short. Field studies in the petroleum industry show that several thousand employees have daily or frequent contact with this material or blends of this material; while it is estimated that tens of thousands of customers are petentially exposed to blends of this material. The above evidence indicates that the petroleum industry is faced with a Berious potential cancer problem. There are many unanswered questions concerning the nature of this hazard and how it might be prevented or controlled. These questions can only be answered by carrying out a program of medical research along the lines which the Medical Advisory Committee is recommending. In case more detailed information is desired, it can be arranged for a member of the Medical Advisory Committee to discuss this question with members of the Safety Committee or Executive Committee of the Board of Directors. API 06958 F o r Information Only - Wot Fcr Publication ii APPENDIX D REPORT TO THE API MEDICAL ADVISORY COMMITTEE BY THE SUBCOMMITTEE ON PERMISSIBLE CONCENTRATIONS Dr. T. M. Frank - Acting Chairman April 2, 19t At its meeting in Boston on April 1, I9W , your Bubcoaniittee voted to report information and recommendations to the Modi cal Advisory Committee as follows : j cooperation vlth the Medical Advisory Committee of the Manufacturing Chemists Association. In conference with Doctors J. M. Carlisle, A. G. Cranch and D. 0. Hamblin, representing the M.C.A. Medical Advisory Committee, Dr. Cranch expressed the opinion that there was no objection to the issuance of API Toxicological Reviews on substances which are or may be included in the Chemical Safety Data Sheets of the Manufacturing Chemists Association oven though there might be inconsistent statements in such publications. Following a discussion of ways and means to facilitate the exchange of information during the formulation of API Toxicological Reviews it was agreed that the members of the MCA Medical Advisory Committee should be made consulting members of the Subcommittee on Permissible Concentrations of the API Medical Advisory Committee. II Work at Harvard University School of Public Soalth. A. M.A.C. Values for 19U8. I Professor Drinker reported a numbor of -changes^adopted by the committee of government hygienists for publication in the 19W M.A.C. Values. He stated that the now values will be made available promptly to all members of the API Committee. B. Basis for Future Changes in M.A.C. Values. Professor .Drinker stated there was definite need for the gathering and publication of quantitative data which would contradict the current theoretical M.A.C. Values on many substances. C. Report on Status of Harvard Work. The subcommittee reviewed and accepted the report dated March 10th from Professor Drinker to Dr. Baird (seo copy attached). D. Toxicological Reviews. The subcommittee recommends that no toxicological reviews should be published on substances for which literature surveys by Professor Drinker and associates reveal little or no available toxicological information, but instead that every six months API 06959 D (Cont') - 2- a list of such substances should be published by API with a statement of the inadequacy of available information. Any . pertinent literature references available on such substances should be cited in the report with an indication as to the character of the information. E. Screening Tests. The subcommittee reviewed and recommends the adoption of the outline presented with Dr. Seeler's letter of March 23rd subject to a consideration of modifications and other mattors dlBcussed with Dr. Sooler at the meeting. F. Powdered Silica-Alumina Catalyst. Following an extended discussion on the need for work on the toxicology of powdered silica-alumina catalyst, the subcommittee voted for two recommendations as follows: 1. ffresh Catalyst Subject to the approval of the Pan American Refining Corporation, Dr. Frank was requested to supply to Professor Drinker a detailed progress report on the results of that company's research work on fresh catalyst. After reviewing the report Professor Drinkor and associates will inform the subebmmittee as to what, if any, additional work should be carried out. 2. Equilibrium Catalyst Subject to the preparation of a program and estimate of cost by Professor Drinker and associates and to the approval of both by the subcommittee, it is recommended that the Medical Advisory Committee should authorize the immediate initiation of tests at Harvard to establish the toxicology of powdered equilibrium silica-alumina catalyst. G. C9 Aromatics Subject to the preparation of a program and estimate of coBt by Professor Drinker and associates and to the approval of both by the subcommittee, it is recommended that the Medical Advisory Committee should authorize the immediate initiation of tests to establish the toxicology of C9 aromatics including cumene and mezytelene. H. CIO, Cll, and C12 Aromatics The subcommittee requested Professor Drinker and associates to review the question of toxicity of CIO, Cll, and CIS aromatics and to report to the subcommittee what toxicological studies, if any, are practicable. API 06960 D (Cont'd) -3- j. Antidote for Kerosine Poisoning The subcommittee recommends that Professor Drinker and associates should be requested to make toxicological studies to determine whether U.S.F. White Mineral Oil, given by mouth, iB a worthwhile antidote for korosine poisoning. Priority in Screening Tests. In concluding the meeting there was a consensus among those present that chairman of the subcommittee should take steps necessary to establish the order of priority to be followed in the making of screening tests on substances for which there is insufficient toxicological information available including those substances listed in Dr. Clinton's progress report dated April 7, 19t7. i API 06961  ( ppSiDIX D ( Cor.t1d) -k- EAEVAHD U m S H S I T T School of Public Health Deoartoent of Industrial Hygiene ' 55 Shattuck Street Boston 15, Massachusetts March 23, 1948 Mr. B. V. Stroop t wartcan Petroleum Institute 50 West 50th Street ` Hew York 20, N. Y. Dear Mr. Stroops I aa enclosing an outline of preliminary toxicity studies designod to serve as a guide in .establishing tentative precautionary measures for the handling of new compounds. This outline follows closely the range finding procedures described by Henry F. Smyth Jr. and Charles P. Carpenter (J. Ind. Hyg. and Tox. < 2, 26, 1944 and 30, 63, 1948). Ve realise that medical men differ widely in their views as to the amount of animal toxicity data necessary for preliminary evaluation of hasards to the human. In view of the many new compounds that are being introduced into the petroleum industry, it is necessary, however, to have a working plan for the preliminary evaluation of the hazards of a new compound, This outline should be considered only as a preliminary draft. Ve are very anxious ta have comments from the Medical Advisory Committee on this problom as we regard it an urgent one. Very truly yours, AOS/s /s/ Albert 0 . Seeler Albert 0. Seeler, K. D. P. S. Since we would like to discuss the matter at next week's meeting, we are preparing some copies to distribute at the time of the meeting. ! > ll <1 I \ API 06962 D (Cont'd) fEl1* -5- TOXICITY STUDIES The studies outlined below are designed only to give sufficient inforconcerning the toxic properties of a new compound to permit a tentative its toxicity with the toxicity of compounds in general use. For c purpose it is essential to know the approximate lethal dose when the material ^Administered by mouth or by inhalation. It is also important to know whether i9 coBipound is absorbed through the skin. Furthermore, some information as to damage to the eyes and to the skin is necessary. , oral toxicity.- The general range of toxicity is determined by administering "c-- ^doses of the compound to rats, using three rats for each dose level. The ^cjjpound is dissolved or dispersed in water and given by stomach tube in doses of o ol 0.05, 0.1, etc. gm. per kgm. These animals are observed for a week. Once the general order of toxicity is known dose levels can be selected to give a toxicity curve from which the ID-50 can be calculated with reasonable accuracy. (The acute toxicity testing will require about 100 rats.) It was agreed by the committee that the above studies would be carried out on rats, guinea pigs, rabbits or possibly other species instead of on the first only. Considerably less than 100 animals of each species will be used. enhw-ute oral toxicity; A four week chronic toxicity test may reveal toxic properties which ore not apparent in the acute experiments. Depending on the nature of the compound it may be given by stomach tube, or by incorporation in the diet. Four groups of ten rats are used, throe groups to receive daily doses of l/2, l / b and 1/8 the acute ID 50, respectively, and the fourth group to serve as a control. About ho rats will be needed for this experiment. It was agreed by the Committee that gross microscopic pathological examinations would be carrlod out on these animals. Acute inhalation toxicity.- An initial experiment 16 conducted in which 10 rats are exposed to saturated vapor far about seven hours. If these animals are still living a week after the exposure, no further preliminary experiments need be performed. If, however, this exposure proves lethal, a preliminary range-finding test will have to be conducted exposing groups of three ratB to widely spaced concentrations of the vapor. Once the approximate lethal range has been determined, rats in groups of ten are exposed to vapor concentrations so chosen as to give data from which an approximate ID 50 can be calculated. If exposure to saturated vapor reveals toxicity, the further evaluation of the hazard as outlined above will require about 100 rats. It was agreed in the Committee that the type and concentration of vapor exposure would depend on the material under study and the uses of that material. In each particular case the type of vapor inhalation study would be decided on the basis of the compound under investigation instead of having a specific rule concerning all such experiments. Skin absorption: The toxic effects following skin absorption are determined by aPplying graded doses of the compound to the akin of rebbits for a 2k-hour period. Because of the expense of the animals involved, these experiments are limited and are only designed to show whether or not skin absorption can occur. Fifteen babbits will be needed for this experiment. API 06963 ^jEKDIX D (Cent'd) -6- irritation: Sene Information as to skin irritation vill be obtained fron ^"eicin absorption experiments. This Information Is supplemented by observing ^ irritation produced on rabbits' skin by exposuresof varying duration. Five jjbits are needed for this experiment. Skin irritation studies in animals are notoriously unreliable as an aid in evaluating hazard to human skin and serve jusreiJ to eliminate those compounds which are very irritating. It was agreed by the Committee that the above studies would be carried out on guinea pigs in place of rabbits and In addition, patch tests would be carried out on 20 human subjects. Where practical, repeated patch tests would be carried out In order to determine whether sensitization devoloped. Towage to the eye: If the compound to be studied is a fluid, various amounts of tJe undiluted liquid are Instilled Into the conjunctival sacs of rabbits. The eyes are carefully observed for a week both for immediate damage and evidence of repair. If the material to be studied Is a solid, various amounts of powder are applied to the eye and the resulting Irritation compared with that produced by equivalent amounts of a relatively inert agent of approximately the same particle size. Twelve rabbits are needed for this experiment. It must be emphasized that these studies will yield only tentative information as to tho toxic properties of a new compound. An accurate evaluation of the toxicity of a new compound Is a major undertaking involving detailed acute and chronic toxicity studies In sevoral animal species using various routes of administration. Changes In the blood picture and In kidney and liver function must be studied and tissues of animals dying or sacrificed during the experiment must be examined by a pathologist. Such a program is obviously only Justified for compounds which will bo used extensively. API 06964 APPENDIX D (Cont'd) HARVARD UKIVEHISTT ' School of Public Health Department of Industrial Hygiene 55 Shattuck Street Boston 15, Massachusetts March 10, 1943 V. C. Baird, K. D. Humble Oil and Refining Co. P. 0. Box 2180 Houston, Texas Dear Dr. Baird: Unfortunately progress on our program has been slowed by a change in personnel. As you know, Dr. Marshall Clinton resigned his position with us last summer. Dr. Albert Seeler, who has taken over Dr. Clinton's responsibilities, began work with us on January 1, 1948, Dr. Seeler will attend your committee meeting with Dr. Clinton and me. ' Bibliographic research for the surveys has been continued without interruption, but work on the evaluation of the literature data and drafting of toxicological reviews has necessarily been delayed. The following tentative reviews have been completed and submitted to your committee for comments: Beta naphthol Methyl cyclohexane Cyclohexane Considerable bibliographic work has been done on the following compounds, some of which were listed in the previous progress report. Tricresol phosphate Barium chloride Barium hydroxide Barium nitrate Benzaldehyde Calcium chloride Calcium hypochlorite Hydrocyanic acid Pyridine Di-alkyl sulfates Hidkel carbonyl Alkyl sulfuric acids Acetic acid Asyl acetate Ammonium acetate Ammonium nitrate Anthracene Bromine Mesitylene Alpha naphthol Tributyl phosphite Alkyl thioether8 Triphenyl phosphate Nitroparaffins Alkyl peroxides Alkyl nitrates Asyl alcohol Carbon Black Acetylene Zthylene dichloride Ammonium chloride Ammonium hydroxide Ammonium molybdate Potassium chromate Potassium hydroxide Potassium iodide API 06965 APPENDIX D (Coat*) -6- Dr. V. C. Baird. March 10, 1948 Calcium hydroxide and calcium oxide Hydroquinone Potassium nitrate Naphtalene Potassium permanganate Potassium Bromide Sulfur trioxide Trichlorethylene Since so many new chemicals of unknown toxicity ore being introduced into the petroleum industry it seems desirable to develop a general plan for preliminary toxicity testing. In all probability no two medical men will be in complete agreement as to the extent of information concerning the toxicity of a new compound required to serve as a guide in setting preliminary standards for safe handling. Nevertheless, since it is not practically possible to perform detailed toxicity studies on all new compounds as they are introduced, it is necessary to have an outline of minimum toxicity studies required. A tentative outline for toxicity testing which is designed only to give the minimum information needed for a preliminary estimate of the relative hazard of a new compound has been prepared and will be distributed to your committee in the near future for comments and suggestions. In the course of the preparation of the toxicological surveys we have become increasingly conscious of the need for uni formity in the publication of toxicological data. Turthermoro, from conversation with toxicologists and Pharmacologists, it is apparent that a great deal of miscellaneous toxicological data has been accumulated which has not been reported in the literature because of the lack of facilities for publication of such material. While the details remain to be worked out, we. believe that the Journal of Industrial Hygiene and Toxicologrshouldvmake available space for the publication of preliminary toxicological data which would not at present be accepted for publication. If this is done it is probable that, in the course of time, workers throughout the world would become accustomed to submit their toxicological data for recording in the Journal of Industrial Hygiene and Toxicology. In addition to devoting a section to the initial publication of such data, a supplement might be issued periodically which would list the accum ulated data in tabular form. Ve feel that such a project would be of value to the petroleum industry and would exoect to support it with some of the funds that you have given us. Sincerely yours, S/ Philip Drinker TO/ew Philip Drinker API 06966 Per Infrmaticn Only - Not Por Publication APPENDIX 5 EXPORT TO TES API MEDICAL AD7ISOHY COMMITTEE BY THS XDITGRI.nL COMMITTEE April 2, 1948 pr> M. N. Newquist, Chairman Pi Medical Advisory Committee Dear S ir : A meeting of the Editorial Committee of the American Petroleum Institute Medical Advisory Committee was held in the Board Boom of the American Petroleum Institute on March 11, 1948, at which time the following toxicological reviews were approved for publication after certain minor editorial changes have been made: Acrylonitrile Alkyl Disulfides Alkyl Hereautans Diethylene Glycol Dowtherm A Kerosine Mercury ethyl Eyhyl Ketone Morpholine Naphthenic Acids N-Butyl Para Amino Phenol Phosnhorus Pentasulfide Sulfur Dioxide Thiophene end Derivatives Publication of the toxicological reviews given below is being deferred until some future date: Ditertiary Butyl Para Cresol Kaleic Anhydride Silica Thiophenol and the Aromatic Kercaptans ' The Editorial Committee will give consideration fro publishing the reviews on ditertiary butyl para cresol and silica after additional information has been obtained. It was recommended that the review on maleic anhydride be redrafted by Professor Drinker and his associates at Harvard University, and that the review on thiophenol and the aromatic mercaptans not be published because of lack of information. The toxicoligical reviews given below were not acted on because Mr. D. 7. Stroop had requested that these review first be discussed with representatives of the Manufacturing Chemists1 Association before publication: Acetone Carbon 'onoxlde Hydrogen Fluoride Phosphoric Acids Members: Dr. 7. C. Baird Dr. Marshall Clinton, Jr. Dr. M. N, Newquist (iot-officio) Mr. D. 7. Stroop Eespectfully submitted, J. ?. Holt, M. D. Chairman API 06967 Jor Inferno"!on Only - Net 1er Publication APPENDIX ? MEMORANDUM April 2, 19U8 SUBJECT: RECEIPTS AND DISBURSEMENTS - API MEDICAL RESEARCH FUND contributions to Fund. 1919^5 Solicitation V7 Solicitation Total $ 28, 900.00 2 7 , 8 0 0.0 0 $ 56,700.00 Disbursements from Fund Harvard University Toxicological Reviews Cutting Oil Dermatitis $ 27,000.00 2,500.00 University of Cincinnati Carcinogenicity Fluorine Study 6 , 000.00 2,500.00 Miscellaneous Book for Committee Use 57.77 Total Disbursements BALANCE ON DEPOSIT 29,500.00 8 , 500.00 57.77 t 38,057-77 $ 18,61*2.23 API 06968