Document rpw5VqjnEqLZqM0b4ByQmp1xr

1. Duration of test: 30 days 2. Animals used: '' a. Bate: 3 test groups of 20 anistale each and on control group of 20 animals b. Dogs: 3 test groups of 6 animals each and one control group of 6 animals '' v . 3. Necropsy: Gross and microscopic studies on major organs of all animals at completion of test A. Other studies: Complete blood counts on all animals at beginning end end of test period. Liver and kidney function tests on all dogs (Method and frequency undefined.) 11. Local irritation 1. Method: Two injections at seme time in each of 10 rabbits, using the sacrospinalia muscle as the site. Sacrifice all animals after five days observation, remove the injected muscles m d examine for evidence of irritation. 0005627 RFGo o drich TheB.F.GoodrichCompany ovember 8, 1961 500So. MainSt. Akron IS, Ohio 253-1171 --r . i v d i o s i-'ettering Laboratory College of Medicine Cincinnati 19, Ohio bear boctor xehoe: We are considering the performance of some animal toxicology on a polymer with the intent of ultimately supporting a new drug application. extensive oral toxicology already exists on the material. The protocol of the studies is enclosed. I would appreciate your advising me if you are interested in performing these studies for us, and their cost. Very truly yours W.b. McCormick, Manager Mepartment of Industrial Hygiene and Toxicology 0005626 ^ / s' N7382