Document rpqKzp5wmja0QvnMNxO2ppY9G

August 1# 1969 Dr. J. E. Long Hinager, Toxicology 3:1 Company 3M Center St. Paul, Minnesota 55101 Dear Jlmi He<ynrdlng vour request ooncernl one 11254, I trust the following pooet* ----1 Aroclor 1232 .J 1232, 1248, 1 your pur* Acute oral LD50 - rat - 4470 mg/kg Acute akin minimal lethal dose - rabbit > > 1 ::Go <2000 mgAs. Although no akin or eye irritation studies were done, v/e know that the liquid Aroclors are good solvents for the normal fats and oils of the akin. Suffi cient akin contact then could lead to drying and chapping. For this reason we recommend that re peated or prolonged skin contaot be avoided. We do not have inhalation data. Wo do not have breakdown products since these are relatively stable compounds. Acuto oral LD50 - Rat - 12,500 mg/kg Acute okln minimum lethal dose - rabbit - >794 <1260 mg/kg. , A study was made using a 4*1 (w/v) solution in corn oil applied dally for 20 applications to the clipped intact skin of rabbits at doaea of 10, 50, and 100 mg/kg/day. The 10 mg/kg/day does had no effeot on body weight hematology and urine analyses when compared to the controls nor were there any gross or mloropathologio findings. DSW 020299 STLCOPCB4008228 Dr. J. E. Long August 1# 1969 Page Two Aroclor*?.. 'SL (Continued) The 50 mg/kg/day dose produoed generalized inactivity# weakness# lassitude# and loss of appetite. There were no significant looal skin reactions. Hema tology and urine analyses were oomparable to the controls. Cross pathologio examination revealed liver disooloration. All other tissues and organs were comparable to the oontrole. Mloro pathologio examination revealed moderate hepatio neoroals. All other tissues and organs were oomparable to the con trols. The 100 mg/kg/day dose was more severe but oomparable to the 50 mg/kg/day dose with regard to hematology# urine analyses# gross end micro pathologio examin ation. We do not have Inhalation nor breakdown produot data* ftroclor 1254 I* Aoute oral LD50 - rat - 11#900 mg/kg Acute skin minimal lethal dose rabbit - >1260 <2000 mg/kg. 20 Day Subacute Dermal - Rabbits Doses were 10# 50# 100# and 200 mg/kg/day. The LD50 was 75 mg/kg/day. No adverse reactions including hematology# urine analyses# gross or micropathology# exoept after ten days aoallng and wrinkling of the skin# was observed from the 10 mg/kg/day dose. The 50# 100# and 200 mg/kg/day dose produced gener alized inactivity# weakness# lassitude and loss of appetite. The 200 mg/kg/day dose produced death before adverse skin reactions were observed* At the 50 and 100 mg/kg/day levels# there were skin reactions which revealed scaling# wrinkling and fissures. At these doses there were no effeots on hematology or urine analyses. Qroaa pathologic examination revealed liver dis coloration. However# all other tissues and organs were oomparable to the oontrola* i DSW 020300 l, STLCOPCB4008229 Dr. J. K. Long Augus t l, 1969 Pago Three 20 Day Subncuto Dermal - Rabbits (Coatlnuod) Mlcroscoplo examination revealed moderate liver necrosis. However, all other tissues and organs were comparable to the oontrols. We do not have inhalation or breakdown data for this produot. If your weather has been anything like ours during July, you wouldn't ask suoh a silly question* Best regards* Sincerely. William H. Hunt, Ph.D. Toxicologist, Nodical Dept* iju DSW 020301 STLCOPCB4008230