Document rppZ2LO44BrGgq1d4arJ3ymxr

**rav evident e ol ash- CANCER FOLLOWING OCCUPATIONAL EXPOSURE TO stimulated the K.nto,, she introduction of ex ASBESTOS AND VINYL CHLORIDE ,r*l technology in tit lishment of an ongoin NVii.ijamJ. N'k.iioi non, PhD gram. Again an upon "The outlook I- decade. or ihcrt-.ilio' I Application of prew A review is presented of the various factors important in the identification of carcinogenic diaeaae from occupational and environ menu! esposure tv nbnloi and vinyl chloride. The long lapsed period, uiually of 20 or more yean from first eapoaurc to thcie material!, it discussed, aa well aa the requirement for sufficiently long obaervation period! in proapcclive epidemiological aiudira. The multiple-factor etiology of lung cancer involving cigarette amoking and aabeatoa eapoaurc ia illuatraled. The riaka of asbestos-related cancera to other than tboee directly working with the material are diaeuaaed in a variety of circumatancea, and finally the effectiveness of control procedure! for vinyl chloride and aabeatoa are compared. Cmtm J:I72-I0I, 1977. Apparent in a grrat i r . fibrosis."" sociatcd with .i'hr**pand. In I'D- .m w*re published of In **s who had died >. fibrosis.'1* While ficient to causally ri fling cancer, the po was confirmed l> INETEEN SEVENTV-HVE WAS THE 20Ofll AS- ctfecis of these two materials is instruct"* * Nniversary of the publication hv Percivall they olfer similar, but in some respects conic**** Pott of hit obaervation* of irrotnl canter amoningg. examplrs tf the current difficulties of idr*11* showed that I.V- asbestosis in (Ire.i genic carcinoma " chimney aweeps in (ireat Britain." Thia pio fying and contrulling carcinogenic material* * *f the lining of : hi neering paper on occupational cancer by an the workplace. scribed in an adx alert aurgeon recognized onr of the salient fea frequently to h.o> ture* of occupational carcinogenesis. the lapted Asbestos Health Effect! **posurr in I 'imi y period between time from first exposure and the The modern history of asbestos disease date such exposure in I manifestation of symptoms. The chimney from the turn of ihr centurv. when two rrp*n' also was found m sweeps were employed at young children, but were published dixumrnnng uncontrolled ft*" insulation woi'kri * the cancers did not appear until after puberty, ditions in asbestos textile factories. One. |"f when they were usually considered venereal in testimonv or l)r. II. Montague Murray a' * In 10"A. three--first identifitaiKe' origin and treated accordingly. This aspect of compensation hearing, described severe Pul* society continue' occupationally induced cancer continues to be rnonary ftltrosis found at autnpsv. in |90fl. >nl^ devil us 200 years later, as we try to identify last survivor of a group ol ten workers first edh ence. unfortunate Moreover, the pi sources of disease among working populations. Since the serious elfertt of exposure to carcino gens do not Itecome clinically manifest for scars, often dccadrs, a causal association is not often easily identified between agent and diseasr. Approximately 100 materials used or ap|>ear- ployed 14 vrars previously in a carding room. At the time of the hearing, in I Of16. f)r. Mum" offered the optimism prognosis. "One heAts. grnernlly speaking, that considerable trouble # now taken to prevent the inhalation of dust. *TM so the disease ia not ao likely to occur as here ' ; _ tral ashesina-n-1,1' thoie directly h. working nenrhv Asbestos materi.i'. simply five in ill lion or in the ho ing in industrial processes have been identified tofore."" The second was the description ** %i ' High Exposure as carcinogens." Fortunately, most havr limited use and few workers are exposed, but some are used extensively. In this latter category are as Aurihault of deaths during the early years alteration of an asbestos weaving mill estab lished at Conde-sur-Xoirrau. France, in l~- a f' The full spei i exposure is best Hammond and ' bestos and vinyl chloride. A review of the health During this period. So men died, including I* 17 recruited from a cotton textile mill previous!* X: 'i rience of p.8m' Table 1 shows t owned by the factory director. g among this gn > I hnemtd at the National (oncer Institute Conform* <m Cancer Epidemiology and the (ainkian. Huston. Mau .Ocrater 2*-2S. I STS. From ite Dept, of Community Medicine. Mount Sinai School of Medicine of the City Unfwratty of New Yurk. New Subsequently, cases of pulmonary fibrosis**** lowing inhalation of asbestos were published the medical literature, including one by Co***who gave the disease its current name, asbev i: - r |C. 1967, through 1 individuals w hwas due to lunc linal cancer. at>. York. NY 1002*. tosis.1 A 1929 study of asbestos textile op*** f * . (a tumor so rar- AftMriMt Prafpwflfe * Address hr reprints: William J. Nichoiaen. PhD. I foil uf Community Medkint, Ml. Sinai School uf Mcdkine. New York. NY 1002k. ' kecetved hr publication January IS. ISTT. ations by the British Factory Inspectorate re vealed the existence and extent of a continuiM problem." In a clinical survey of mill employ*"811% of ihose employed for 20 years or more had may nreount In in the absence 1792 8004 0027 HFM -011688 SCF-FA-1180