Document rpk0D2GXZrXqgyRyxEgDX9z87

r -- ------------------------------------- ---- ------- -- -- -------------------------------404 TRADE SECRET Study Title H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 4 of 5 Laboratory Project ID: DuPont-5990 DuPont-5990 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) Author: Susan A. MacKenzie, V.M.D., Ph.D., D.A.B.T. Study Completed ON: January 18,2002 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Page 918 of 1408 Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646507 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology LIVER : HYPERPLASIA, BILIARY, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN, THYROID GLAND 646511 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646511 Continued on the next page -919- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646511 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND 646530 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND -920- Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646537 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGJS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. UTERUS : DILATATION, LUMEN, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646537 Continued on the next page .... -921 - Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646537 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I Sc II, NOSE III & IV 646538 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN 646538 Continued on the next page .... - 922- Compny Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646538 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPIJ NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646549 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 646549 Continued on the next page .... -923- Company Sanitized. Does not contain TSCA C8I H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646549 Continued from previous page Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN, THYROID GLAND 646551 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : KIDNEYS : CYST, CLEAR, LEFT, 3MM DIA. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 646551 Continued on the next page -924- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646551 Continued from previous page Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND 646560 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : PARATHYROID GLANDS : MISSING. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646560 Continued on the next page .... -925- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646560 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS ,t MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV ORGANS NOT EXAMINED: PARATHYROID GLANDS 646565 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 646565 Continued on the next page .... -926- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646565 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN, THYROID GLAND 646580 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month RecoveryAnimal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN 646580 Continued on the next page .... -927- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646580 Continued from previous page Histopathology No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND 646581 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy , Gross Pathology : KIDNEYS : DILATATION, RIGHT, PELVIS. CYST, RIGHT, 2MM DIAMETER. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : HYDRONEPHROSIS, UNILATERAL, moderate CAUSE OF DEATH : SACRIFICE BY DESIGN. 646581 Continued on the next page .... -928- Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646581 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, SPLEEN, THYROID GLAND 646586 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE,' SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND -929- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group ;: II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646588 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS , Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN, THYROID GLAND 646592 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646592 Continued on the next page -930- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646592 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, mild. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. PARATHYROID GLANDS : MISSING. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III Sc IV ORGANS NOT EXAMINED: PARATHYROID GLANDS -931 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646597 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PYELONEPHRITIS, UNILATERAL, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : SPLEEN 646612 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646612 Continued on the next page -932- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646612 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV -933 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646613 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND -934- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646617 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, 646617 Continued on the next page .... -935 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646617 Continued from previous page Histopathology : No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646627 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal CAUSE OF DEATH : SACRIFICE BY DESIGN. 646627 Continued on the next page .... -936- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646627 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN 646649 * Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. SPLEEN : PIGMENT INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646649 Continued on the next page .... - 937- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646649 Continued from previous page Histopathology No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646652 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 646652 Continued on the next page -938 - Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646652 Continued from previous page Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND 646659 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646659 Continued on the next page .... -939- Company Sanitized. Does not contain TSCA C8I H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646659 Continued from previous page Histopathology No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646665 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 646665 Continued on the next page -940- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646665 Continued from previous page Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646676 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646676 Continued on the next page .... -941 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646676 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, > FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV -942- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646502 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : INFLAMMATION, LYMPHOID, CORTICAL, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN, THYROID GLAND -943- Company Sanitized. Does not contain TSCA CBI H90--2P4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646522 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN 646531 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS 646531 Continued on the next page .... -944- Company Sanitized. Does not contain TSCA C8I H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646531 Continued from previous page Histopathology CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND 646567 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : PITUITARY GLAND : LARGE, mild. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal 646567 Continued on the next page .... -945- Company Sanitized. Does not contain TSCA C8I H90--2D47a6y8G: aSvuagbechSrtoundiyc iTnoRxaictistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646567 Continued from previous page Histopathology : PITUITARY GLAND : NO MICROSCOPIC EVIDENCE OF MACROSCOPIC FINDING. CAUSE OF DEATH : SACRIFICE BY DESIGN. t No Microscopic Abnormality Observed : LIVER, SPLEEN, PITUITARY GLAND, THYROID GLAND 646568 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN -946- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646576 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : * LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN -947- Company Sanitized. Does not contain TSCA C8I H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646595 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN, THYROID GLAND -948- Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646621 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS., LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : SPLEEN : HEMATOPOIESIS, INCREASED, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, THYROID GLAND 646625 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS 646625 Continued on the next page .... -949- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646625 Continued from previous page Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN 646626 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND -950- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646635 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN -951 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646636 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : THYROID GLAND : ' ONLY ONE THYROID PRESENT AT TRIMMING, NO THYROID WEIGHTS WERE TAKEN. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN 646660 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND 646660 Continued on the next page .... -952- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646660 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN 646664 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646664 Continued on the next page .... -953- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646664 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT,, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN 646673 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646673 Continued on the next page -954- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646673 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, ' FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN -955- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646501 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. -956- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646505 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : PITUITARY GLAND : LARGE. UTERUS : LARGE. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, mild. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. UTERUS : DILATATION, LUMEN, mild. 646505 Continued on the next page .... -957- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646505 Continued from previous page Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN. 646510 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 646510 Continued on the next page .... -958- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646510 Continued from previous page Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN. 646533 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : XX : ANIMAL CAME TO NECROPSY AK, ONLY FLOURINE AND HISTO SAVED.. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology : SPLEEN : PIGMENT INCREASED. THYROID GLAND : MISSING. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS ORGANS NOT EXAMINED: THYROID GLAND -959- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646534 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : * LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN -960- Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646556 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : PITUITARY GLAND : LARGE. MAMMARY GLAND (FEMALE) : LARGE, VENTRAL. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. MAMMARY GLAND (FEMALE) : HYPERPLASIA, LOBULAR, mild. 646556 Continued on the next page .... -961 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646556 Continued from previous page Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN. 646578 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646578 Continued on the next page .... -962- Company Sanitized. Does not contain TSCA CBI 9H0--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646578 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, SPLEEN 646608 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN -963- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646624 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. -964- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646629 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : * LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN -965- Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuabgechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646630 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND,`PARATHYROID GLANDS Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, moderate. SPLEEN : PIGMENT INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER 646632 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS 646632 Continued on the next page .... -966- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646632 Continued from previous page Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF'DEATH : SACRIFICE BY DESIGN. minimal. No Microscopic Abnormality Observed : LIVER, SPLEEN 646633 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 646633 Continued on the next page -967- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646633 Continued from previous page Histopathology LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS 646634 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : KIDNEYS : SMALL, RIGHT, IRREGULAR. No Macroscopic Abnormality Observed : LIVER, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology : 646634 KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal THYROID GLAND : ALTERATION, COLLOID, minimal. Continued on the next page .... -968- Company Sanitized. Does not contain TSCA C8I H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646634 Continued from previous page Histopathology CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN * 646656 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN -969- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646506 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : f LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. minimal. No Microscopic Abnormality Observed : LIVER, SPLEEN -970- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646508 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN -971 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646509 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : PIGMENT INCREASED, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, mild. ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646509 Continued on the next page .... -972- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646509 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646523 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646523 Continued on the next page .... -973- Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646523 Continued from previous page Histopathology : No Microscopic Abnormality Observed : SPLEEN 646528 Terminal Sacrifice Killed on Day : 183 * Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN -974- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646535 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : MANDIBULAR LYMPH NODE : t DISCOLORATION, BILATERAL. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : HYPERTROPHY, CENTRILOBULAR, mild. SPLEEN : PIGMENT INCREASED, minimal. MANDIBULAR LYMPH NODE : CONGESTION, mild. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. PARATHYROID GLANDS : MISSING. 646535 Continued on the next page -975- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646535 Continued from previous page Histopathology : EYE(S ) WITH OPTIC NERVE : HEMORRHAGE/INFLAMMATION (BLEEDING PROCEDURE). CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV ORGANS NOT EXAMINED: PARATHYROID GLANDS 646536 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : LIVER : LARGE. 646536 Continued on the next page .... -976- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646536 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, moderate. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, moderate. SPLEEN : PIGMENT INCREASED, minimal. HEMATOPOIESIS, INCREASED, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 646536 Continued on the next page .... -977- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646536 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646540 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild. 646540 Continued on the next page .... -978- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646540 Continued from previous page Histopathology CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN 646542 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, moderate. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal 646542 Continued on the next page .... -979- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646542 Continued from previous page Histopathology CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN 646545 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal SPLEEN : HEMATOPOIESIS, INCREASED, minimal. 646545 Continued on the next page .... -980- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646545 Continued from previous page Histopathology THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER 646548 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal 646548 Continued on the next page .... -981 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646548 Continued from previous page Histopathology THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN 646577 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild 646577 Continued on the next page .... -982- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646577 Continued from previous page Histopathology : SPLEEN : PIGMENT INCREASED, minimal. HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. UTERUS : DILATATION, LUMEN, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV -983 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646593 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. SPLEEN : PIGMENT INCREASED, minimal. HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646593 Continued on the next page .... -984- Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuabgechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646593 Continued from previous page Histopathology No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY ` GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646599 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 646599 Continued on the next page -985- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646599 Continued from previous page Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN 646601 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : xx : ANIMALS CAME TO NECROPSY AK, ONLY FLOURINE AND HISTO TISSUE SAVED.. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, mild SPLEEN : PIGMENT INCREASED, minimal. 646601 Continued on the next page .... -986- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646601 Continued from previous page Histopathology THYROID GLAND : MISSING. CAUSE OF DEATH : SACRIFICE BY DESIGN. M No Microscopic Abnormality Observed : LIVER ORGANS NOT EXAMINED: THYROID GLAND 646609 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 646609 Continued on the next page -987- Company Sanitized. Does not contain TSCA C8I H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxaictistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646609 Continued from previous page Histopathology ; LIVER : HYPERTROPHY, CENTRILOBULAR, mild. SPLEEN : PIGMENT INCREASED, minimal. HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. UTERUS : DILATATION, LUMEN, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV -988 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646610 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. NECROSIS, INDIVIDUAL CELL, mild. INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : PIGMENT INCREASED, minimal. HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646610 Continued on the next page .... -989- Company Sanitized. Does not contain TSCA CB1 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646610 Continued from previous page Histopathology No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646614 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 646614 Continued on the next page -990- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646614 Continued from previous page Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : PIGMENT INCREASED, minimal. HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV -991 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646618 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : SPLEEN -992- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646620 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN, THYROID GLAND 646637 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month RecoveryAnimal is signed off from necropsy Gross Pathology : STOMACH : ULCER/EROSION, GLANDULAR, 3MM DIA. 646637 Continued on the next page -993- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646637 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : STOMACH : EROSION/ULCER, ACUTE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN -994- CompSny Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646650 Terminal Sacrifice Killed on Day : 124 Exposure Group : 1-Month RecoveryAnimal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN 646657 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : LIVER : LARGE. 646657 Continued on the next page -995- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646657 Continued from previous page Gross Pathology : PITUITARY GLAND : LARGE, mild. No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, ' BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, mild. SPLEEN : PIGMENT INCREASED, minimal. HEMATOPOIESIS, INCREASED, mild. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, mild. UTERUS : DILATATION, LUMEN, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646657 Continued on the next page .... -996- Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646657 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646667 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, mild. SPLEEN : PIGMENT INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646667 Continued on the next page .... -997- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646667 Continued from previous page Histopathology No Microscopic Abnormality Observed : LIVER 646669 * Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : SKIN : ALOPECIA, BILATERAL, HINDLIMB. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. NECROSIS, INDIVIDUAL CELL, minimal. INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal 646669 Continued on the next page .... -998- Company Sanitized. Does not contain TSCA CBi H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646669 Continued from previous page Histopathology : SPLEEN : PIGMENT INCREASED, minimal. STOMACH : EROSION/ULCER, ACUTE, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. SKIN : ALOPECIA/HYPOTRICHOSIS, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I Sc II, NOSE III & IV -999- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 APPENDIX O REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF P, MALE RATS - 1000 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF Pi MALE RATS EXPLANATORY NOTES Notes Test Days 72-86 = Cohabitation period DuPont-5990 - 1001 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY W E IGHTS (grams) OF P x MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 646328 646479 646470 646461 646480 646383 646445 646358 646425 646408 77 84 91 98 484.9 492.9 507.4 569.2 590.9 603.6 576.2 490.6 562.5 575.7 599.2 727.7 550.6 540.1 468.6 606.2 488.4 529.9 529.1 565.0 502.9 505.3 524.3 573.3 591.7 634.2 590.7 499.2 565.6 593.3 618.4 754.6 578.0 559.8 482.9 612.6 502.4 554.9 548.6 581.3 515.2 527.9 485.8 581.4 609.0 657.7 605.3 510.4 572.4 607.7 639.0 773.3 582.0 572.2 495.7 633.1 515.2 564.3 559.4 594.4 528.8 535.6 514.2 595.7 622.1 689.1 614.3 524.4 584.0 612.9 646.0 782.8 593.5 590.2 503.6 651.7 530.7 573.0 567.6 614.8 - 1002 - Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T S (grams) OF Px MALE RATS GROUP: III-O DOSE: 25 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 646378 646483 646363 646334 646493 646404 646415 646410 646340 646354 646467 646381 646342 646450 646326 646377 646478 646350 646333 646486 77 84 91 98 509.2 584.5 540.3 570.5 606.9 589.9 570.8 541.4 487.5 547.9 603.6 559.2 609.3 549.4 560.1 558.4 708.5 555.8 515.8 443.6 508.8 594.9 560.9 583.7 628.3 604.5 581.8 548.3 497.8 559.5 576.0 576.8 616.8 558.1 566.1 575.4 745.7 569.5 517.4 448.0 523.8 608.7 583.8 597.0 644.3 618.7 593.4 563.9 519.5 574.2 626.3 583.5 631.9 575.4 570.9 585.6 776.1 579.5 535.1 454.3 527.2 626.7 601.6 610.6 661.1 636.8 616.1 575.9 527.5 591.3 648.1 606.2 659.3 585.3 588.3 605.1 799.4 610.0 558.9 475.6 - 1003 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T S (grams) O F Pi M A L E R A T S GROUP: V-0 DOSE: 100 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 646353 646341 646356 646330 646499 646400 646417 646338 646394 646387 646447 646336 646366 646496 646375 646465 646390 646429 646476 646348 77 84 91 98 489.3 545.0 537.3 529.1 557.5 540.0 511.8 499.5 574.4 507.1 500.2 487.4 515.3 507.1 549.3 518.9 456.8 560.3 465.5 498.6 516.4 565.5 546.6 524.8 573.2 540.8 527.2 522.5 587.5 519.7 509.7 485.3 533.1 529.1 562.4 530.6 481.9 571.5 485.0 503.5 537.1 575.0 566.2 528.3 586.7 547.1 539.7 536.1 609.5 523.3 520.6 490.8 543.5 543.7 569.6 545.3 498.7 586.0 512.5 510.8 556.7 591.8 587.2 539.5 598.6 564.4 551.2 542.9 624.9 541.3 538.8 499.1 555.8 549.4 572.2 549.9 528.3 597.9 529.6 526.6 - 1004- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T S (g r a m s ) OF Pi M A L E R A T S GROUP: V I I -0 DOSE: 500 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 646382 646406 646491 646351 646405 646418 646362 646497 646401 646498 646386 646332 646441 646452 646365 646393 646359 646451 > 77 84 91 98 407.7 453.5 501.7 465.1 453.0 468.4 410.8 436.9 518.1 543.4 562.5 389.6 474.3 426.3 435.5 477.2 503.4 393.3 417.8 460.4 513.4 482.0 457.5 470.8 408.2 452.8 526.3 559.7 582.4 387.4 475.5 432.9 456.6 489.3 514.1 415.8 432.1 470.3 527.1 493.3 469.0 480.8 411.7 468.6 528.9 569.3 592.3 407.0 490.0 445.0 465.3 503.5 506.8 426.8 444.7 479.3 544.2 500.8 480.7 496.2 423.4 467.9 536.5 604.7 617.0 410.8 511.4 443.7 473.0 434.4 512.6 439.5 -1005- Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 APPENDIX P REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF P, MALE RATS - 1006 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF Pj MALE RATS EXPLANATORY NOTES Notes Test Days 72-86 Cohabitation period DuPont-5990 - 1007 - Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY W E I G H T GAINS (grams) OF Px MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 646328 646479 646470 646461 646480 646383 646445 646358 646425 646408 77-84 84-91 91-98 77-98 18.0 12.4 16.9 4.1 0.8 30.6 14.5 8.6 3.1 17.6 19.2 26.9 27.4 19.7 14.3 6.4 14.0 25.0 19.5 16.3 12.3 22.6 -38.5 8.1 17.3 23.5 14.6 11.2 6.8 14.4 20.6 18.7 4.0 12.4 12.8 20.5 12.8 9.4 10.8 13.1 13.6 7.7 28.4 14.3 13.1 31.4 9.0 14.0 11.6 5.2 7.0 9.5 11.5 18.0 7.9 18.6 15.5 8.7 8.2 20.4 43.9 42.7 6.8 26.5 31.2 85.5 38.1 33.8 21.5 37.2 46.8 55.1 42.9 50.1 35.0 45.5 42.3 43.1 38.5 49.8 - 1008 - Company Sanitized. Does not contain TSCA CBI H90--2D4a76y8G: aSvuagbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T G A I N S (grams) O F Pi M A L E R A T S GROUP: III-O DOSE: 25 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 646378 646483 646363 646334 646493 646404 646415 646410 646340 646354 646467 646381 646342 646450 646326 646377 646478 646350 646333 646486 77-84 84-91 91-98 77-98 -0.4 10.4 20.6 13.2 21.4 14.6 11.0 6.9 10.3 11.6 -27.6 17.6 7.5 8.7 6.0 17.0 37.2 13.7 1.6 4.4 15..0 13..8 22 ..9 13 .3 16..0 14..2 11..6 15..6 21..7 14..7 50..3 6..7 15..1 17..3 4..8 10..2 30..4 10..0 17..7 6..3 3 .4 18..0 17 .8 13 .6 16..8 18 .1 22 .7 12 .0 8..0 17..1 21..8 22 ,.7 27..4 9..9 17 .4 19..5 23 .3 30 .5 23 .8 21..3 18..0 42..2 61..3 40..1 54..2 46..9 45..3 34..5 40..0 43 .4 44..5 47..0 50..0 35..9 28..2 46..7 90..9 54..2 43..1 32..0 -1009- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Px MALE RATS GROUP: V-0 DOSE : 100 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 646353 646341 646356 646330 646499 646400 646417 646338 646394 646387 646447 646336 646366 646496 646375 646465 646390 646429 646476 646348 77-84 27.1 20.5 9.3 -4.3 ' 15.7 0.8 15.4 23.0 13.1 12.6 9.5 -2.1 17.8 22.0 13.1 11.7 25.1 11.2 19.5 4.9 84-91 20.7 9.5 19.6 3.5 13.5 6.3 12.5 13.6 22.0 3.6 10.9 5.5 10.4 14.6 7.2 14.7 16.8 14.5 27.5 7.3 91-98 19.6 16.8 21.0 11.2 11.9 17.3 11.5 6.8 15.4 18.0 18.2 8.3 12.3 5.7 2.6 4.6 29.6 11.9 17.1 15.8 77-98 67.4 46.8 49.9 10.4 41.1 24.4 39.4 43.4 50.5 34.2 38.6 11.7 40.5 42.3 22.9 31.0 71.5 37.6 64.1 28.0 - 1010- Company Sanitized. Does not contain TSCA C8I H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Px MALE RATS GROUP: VII-0 DOSE: 500 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 646382 646406 646491 646351 646405 646418 646362 646497 646401 646498 646386 646332 646441 646452 646365 646393 646359 646451 77-84 84-91 91-98 77-98 10.1 6.9 11.7 16.9 4.5 2.4 -2.6 15.9 8.2 16.3 19.9 -2.2 1.2 6.6 21.1 12.1 10.7 22.5 14.3 9.9 13.7 11.3 11.5 10.0 3.5 15.8 2.6 9.6 9.9 19.6 14.5 12.1 8.7 14.2 -7.3 11.0 12.6 9.0 17.1 7.5 11.7 15.4 11.7 -0.7 7.6 35.4 24.7 3.8 21.4 -1.3 7.7 -69.1 5.8 12.7 37.0 25.8 42.5 35.7 27.7 27.8 12.6 31.0 18.4 61.3 54.5 21.2 37.1 17.4 37.5 -42.8 9.2 46.2 - 1011 - Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 APPENDIX Q REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING GESTATION -1012 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF P, FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a No litter was delivered; data were excluded from statistical analysis. b No gestation data were collected since no copulation plug was observed; however a litter was delivered. c No gestatiort data were collected since no copulation plug was observed; no litter was delivered. d Start of gestation miscalculated; data were excluded from statistical analysis. e No litter observed; however, implantation sites were present at necropsy. Data were excluded from statistical analysis. Abbreviations -- = No Data -1013 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHTS (grams) OF Px FEMALE RATS DURING GESTATION GROUP: I I -0 DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 646653 646575 646585a 646622 646550 646526 646503 6466441? 646604 646651 646552a 646606 646557 646591 646544 646646 646520a 646569 646654 646668 0 7 14 21 276.7 348.3 282.0 355.3 360.2 282.0 289.7 -- 296.6 312.9 302.4 255.8 299.0 278.3 316.3 317.3 251.3 320.1 301.3 342.4 321.8 345.9 295.1 387.3 382.8 337.1 329.1 -- 333.4 342.2 300.8 289.6 333.1 314.1 354.9 357.3 277.6 348.4 332.8 381.3 364.6 388.8 302.5 422.6 417.2 374.7 359.0 -- 367.2 368.0 317.7 319.4 366.2 348.5 395.5 395.7 291.1 380.2 363.0 415.3 465.2 452.1 308.0 516.8 480.4 458.5 465.9 -- 458.1 464.9 333.3 407.0 415.7 443.3 496.9 497.3 290.3 486.3 461.3 491.7 - 1014- Company Sanitized. Does not contain TSCA C8I H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHTS (grams) OF Px FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 646638 646559 646598a 646561 646573a 646504 646587a 646631a 646529 646603 646554a 646579 646564a 646672 646584a 646543 646596 646558a 646670a 646553 0 7 14 21 305.5 310.7 358.5 ,308.8 308.8 287.5 272.1 375.2 295.5 297.6 320.2 275.9 310.7 321.6 302.7 286.0 285.6 301.9 345.1 316.0 341.9 350.0 375.4 348.9 346.4 314.5 274.5 389.8 332.3 327.5 340.5 313.1 323.8 365.9 318.1 301.6 311.2 325.1 329.9 346.5 392.7 372.7 388.4 375.5 359.3 339.9 284.6 392.7 364.1 357.1 353.4 342.3 331.8 397.0 323.4 335.1 351.7 322.6 344.8 374.7 501.4 468.6 389.6 437.6 347.6 428.6 279.5 400.0 444.1 428.7 342.6 426.4 332.9 492.6 320.8 387.4 ' 431.4 330.9 340.2 451.5 -1015- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T S (grams) O F Pi F E M A L E R A T S D U R I N G G E S T A T I O N GROUP: VI-0 DOSE: 100 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 646547 646666a 646607 646524e 646600 646648 646594 646546 646661a 646671 646521 646590a 646645 646555a 646605a 646589a 646615 646527a 646647 646675a 0 7 14 21 296.4 372.3 303.0 -- 300.2 273.5 290.8 287.2 303.7 296.5 293.3 294.5 266.9 314.7 291.3 243.1 292.0 305.8 303.1 316.6 335.9 364.4 366.9 -- 339.5 294.8 322.8 313.7 333.8 338.4 320.7 316.0 299.7 334.1 325.5 245.0 317.6 315.2 326.0 322.3 373.7 373.2 381.8 -- 372.9 325.8 378.0 343.6 337.6 366.3 343.5 334.5 335.8 334.3 329.5 254.6 346.9 316.4 351.9 325.0 489.0 371.8 492.2 -- 470.8 391.9 452.3 441.2 344.6 454.4 390.6 338.1 410.4 337.0 326.7 257.3 438.1 316.2 461.4 323.1 -1016- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHTS (grams) OF Px FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY GESTATION DAYS : ANIMAL NUMBER 646662 646583a 646623 646619 646539 646628a 646616a 646563a 646641 646572 646512 646566 646570a 646602 646582a 646655 646663d 646640e 646574 646532 0 7 14 21 242.9 287.1 279.1 312.0 324.5 278.7 291.4 290.8 305.5 237.0 284.0 273.1 269.2 274.7 298.5 291.1 294.9 292.7 296.3 288.7 264.2 317.9 323.8 338.0 341.0 315.4 311.5 299.4 343.2 272.4 298.6 283.4 283.3 298.1 293.4 313.0 323.3 304.8 324.7 323.3 293.9 334.2 338.4 ,372.1 380.1 323.3 321.6 301.2 376.7 293.8 298.0 319.9 311.4 313.5 301.3 339.8 384.5 326.2 360.0 355.3 352.7 325.3 401.4 446.8 464.5 315.1 309.9 303.5 450.3 333.4 297.4 383.9 386.2 351.2 303.0 415.3 -- 264.2 424.4 440.0 - 1017- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 APPENDIX R REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF P, FEMALE RATS DURING GESTATION - 1018 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5990 INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a No litter was delivered; data were excluded from statistical analysis. b No gestation data were collected since no copulation plug was observed; however a litter was delivered. c No gestation data were collected since no copulation plug was observed; no litter was delivered. d Start of gestation miscalculated; data were excluded from statistical analysis. e No litter observed; however, implantation sites were present at necropsy. Data were excluded from statistical analysis. Abbreviations -- = No Data -1019 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T G A I N S (grams) O F Pj. F E M A L E R A T S D U R I N G G E S T A T I O N GROUP: I I -0 DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 646653 646575 646585a 646622 646550 646526 646503 646644* 646604 646651 646552a 646606 646557 646591 646544 646646 646520a 646569 646654 646668 1 o 7-14 14-21 0-21 45.1 -2.4 13.1 32.0 22.6 55.1 39.4 -- 36.8 29.3 -1.6 33.8 34.1 35.8 38.6 40.0 26.3 28.3 31.5 38.9 42.8 42.9 7.4 35.3 34.4 37.6 29.9 -- 33.8 25.8 16.9 29.8 33.1 34.4 40.6 38.4 13.5 31.8 30.2 34.0 100.6 63.3 5.5 94.2 63.2 83.8 106.9 -- 90.9 96.9 15.6 87.6 49.5 94.8 101.4 101.6 -0.8 106.1 98.3 76.4 188.5 103.8 26.0 161.5 120.2 176.5 176.2 -- 161.5 152.0 30.9 151.2 116.7 165.0 180.6 180.0 39.0 166.2 160.0 149.3 - 1020 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T G A I N S (grams) O F Pj. F E M A L E R A T S D U R I N G G E S T A T I O N GROUP: IV-0 DOSE: 25 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 646638 646559 646598a 646561 646573a 646504 646587a 646631a 646529 646603 646554a 646579 646564a 646672 646584a 646543 646596 646558a 646670a 646553 0-7 7-14 14-21 0-21 36.4 39.3 16.9 40.1 37.6 27.0 2.4 14.6 36.8 29.9 20.3 37.2 13.1 44.3 15.4 15.6 25.6 23.2 -15.2 30.5 50.8 22.7 13.0 26.6 12.9 25.4 10.1 2.9 31.8 29.6 12.9 29.2 8.0 31.1 5.3 33.5 40.5 -2.5 14.9 28.2 108.7 95.9 1.2 62.1 -11.7 88.7 -5.1 7.3 80.0 71.6 -10.8 84.1 1.1 95.6 -2.6 52.3 79.7 8.3 -4.6 76.8 195.9 157.9 31.1 128.8 38.8 141.1 7.4 24.8 148.6 131.1 22.4 150.5 22.2 171.0 18.1 101.4 145.8 29.0 -4.9 135.5 - 1021 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T G A I N S (grams) O F Pi F E M A L E R A T S D U R I N G G E S T A T I O N GROUP: VI-0 DOSE: 100 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 646547 646666a 646607 646524e 646600 646648 646594 646546 646661a 646671 646521 646590a 646645 646555a 646605a 646589a 646615 646527a 646647 646675a 0-7 7-14 14-21 0-21 39.5 -7.9 63.9 -- 39.3 21.3 32.0 26.5 30.1 41.9 27.4 21.5 32.8 19.4 34.2 1.9 25.6 9.4 22.9 5.7 37.8 8.8 14.9 -- 33.4 31.0 55.2 29.9 3.8 27.9 22.8 18.5 36.1 0.2 4.0 9.6 29.3 1.2 25.9 2.7 115.3 -1.4 110.4 -- -V -- 97.9 66.1 74.3 97.6 7.0 88.1 47.1 3.6 74.6 2.7 -2.8 2.7 91.2 -0.2 109.5 -1.9 192.6 -0.5 189.2 -- 170.6 118.4 161.5 154.0 40.9 157.9 97.3 43.6 143.5 22.3 35.4 14.2 146.1 10.4 158.3 6.5 -1022 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Px FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 646662 646583a 646623 646619 646539 646628a 646616a 646563a 646641 646572 646512 646566 646570a 646602 646582a 646655 646663d 646640e 646574 646532 0-7 7-14 14-21 0-21 21.3 30.8 44.7 26.0 16.5 36.7 20.1 8.6 37.7 35.4 14.6 10.3 14.1 23.4 -5.1 21.9 28.4 12.1 28.4 34.6 29.7 16.3 14.6 34.1 39.1 7.9 10.1 1.8 33.5 21.4 -0.6 36.5 28.1 15.4 7.9 26.8 61.2 21.4 35.3 32.0 58.8 -8.9 63.0 74.7 84.4 -8.2 -11.7 2.3 73.6 39.6 -0.6 64.0 74.8 37.7 1.7 75.5 -- -62.0 64.4 84.7 109.8 38.2 122.3 134.8 140.0 36.4 18.5 12.7 144.8 96.4 13.4 110.8 117.0 76.5 4.5 124.2 -- -28.5 128.1 151.3 - 1023 - Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 APPENDIX S REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF P, FEMALE RATS DURING LACTATION - 1024 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF P, FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes a No litter was delivered; therefore no lactation data were collected. b No data due to weighing error. c All pups were found dead on Lactation Day 0. Data were excluded from statistical analysis. Abbreviations -- = No Data - 1025 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T S (grams) O F Pi F E M A L E R A T S D U R I N G L A C T A T I O N GROUP: II-O DOSE: 0 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 646653 646575 646585a 646622 646550 646526 646503 646644 646604 646651 646552a 646606 646557 646591 646544 646646 646520a 646569 646654 646668 0 7 14 21 325.0 361.4 -- 383.0 340.4 367.8 332.5 323.2 337.0 __ b -- 309.2 342.2 322.0 374.8 368.5 -- 361.3 346.0 390.9 354.1 383.8 -- 393.2 343.4 368.2 351.7 356.8 358.1 358.4 -- 297.9 333.3 335.8 375.8 386.1 -- 368.3 354.1 393.7 371.6 401.0 -- 417.6 355.8 384.3 380.7 359.3 388.2 376.2 -- 332.9 360.4 360.1 382.3 396.1 -- 386.9 379.3 429.5 357.9 375.5 -- 388.5 361.8 348.3 350.9 277.7 371.9 351.9 -- 313.7 339.0 324.6 359.8 361.2 -- 368.7 356.5 392.2 - 1026 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T S (grams) O F Pi F E M A L E R A T S D U R I N G L A C T A T I O N GROUP: IV-0 DOSE: 25 MG/KG/DAY LACTATION DAYS : ANIMAL NUMBER 646638 646559 646598a 646561 646573a 646504 646587a 646631a 646529 646603 646554a 646579 646564a 646672 646584a 646543 646596 646558a 646670a 646553 0 7 14 21 365.8 353.8 -- 369.3 -- 303.2 -- -- 350.0 325.0 -- 305.1 -- 379.0 -- __ b 314.6 -- -- 373.9 368.5 357.0 -- 379.0 -- 331.6 -- -- 348.4 359.9 -- 323.8 -- 388.0 -- 329.5 328.1 -- -- 376.9 375.7 365.6 -- 381.6 -- 369.3 -- -- 356.4 348.0 -- 340.4 -- 389.2 -- 341.1 353.5 -- -- 390.4 363.4 339.2 -- 361.1 -- 360.6 -- -- 350.1 354.0 -- 287.4 -- 376.8 -- 325.3 341.5 -- -- 303.7 - 1027 - Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHTS (grams) OF P x FEMALE RATS DURING L A C T ATION GROUP: VI-0 DOSE: 100 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 646547 646666a 646607 6465243 646600 646648 646594 646546 6466613 646671 646521 6465903 646645 6465553 6466053 6465893 646615 6465273 646647 6466753 0 7 14 21 351.1 367.2 324.6 315.8 341.9 315.9 321.8 306.6 300.2 -- -- 334.1 332.0 -- 372.7 371.3 355.5 348.6 356.9 340.1 323.0 351.9 334.7 -- -- 318.1 354.4 -- 368.1 378.9 380.4 351.8 345.8 365.6 338.0 375.7 355.2 -- -- 304.0 364.8 -- 342.3 375.3 362.2 312.7 364.7 352.4 350.0 373.1 351.6 -- -- 348.4 344.0 -- - 1028 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHTS (grams) OF Px FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 646662 646583a 646623 646619 646539 646628a 646616a 646563a 646641 646572 646512 646566 646570a 646602 646582a 646655 646663 646640a 646574e 646532 0 7 14 21 261.0 -- 335.6 345.3 375.4 -- -- -- 346.1 291.3 275.8 286.2 -- 286.5 -- 309.4 292.1 -- 303.4 331.2 288.0 -- 327.3 340.6 373.6 -- -- -- 368.7 296.5 299.3 318.8 -- 314.9 -- 325.5 311.8 -- 340.8 361.4 291.1 -- 355.8 351.5 389.5 -- -- -- 376.5 300.9 327.4 318.3 -- 309.8 -- 331.5 332.1 -- 333.7 340.7 287.1 -- 357.3 356.3 406.7 -- -- -- 374.4 305.7 327.7 317.6 -- 293.3 -- 303.0 336.2 -- 335.3 347.3 - 1029 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX T REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING LACTATION - 1030 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5990 INDIVIDUAL BODY WEIGHT GAINS OF Pj FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes a No litter was delivered; therefore no lactation data were collected. b No data due to weighing error. c All pups were found dead on Lactation Day 0. Data were excluded from statistical analysis. > Abbreviations -- = No Data -1031 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T G A I N S (grams) O F Pi F E M A L E R A T S D U R I N G L A C T A T I O N GROUP: II-O DOSE: 0 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 646653 646575 646585a 646622 646550 646526 646503 646644 646604 646651 646552a 646606 646557 646591 646544 646646 646520a 646569 646654 646668 0-7 7-14 14-21 0-21 29.1 22.4 -- 10.2 3.0 0.4 19.2 33.6 21.1 -- jb -- -11.3 -8.9 13.8 1.0 17.6 -- 7.0 8.1 2.8 17.5 17.2 -- 24.4 12.4 16.1 29.0 2.5 30.1 17.8 -- 35.0 27.1 24.3 6.5 10.0 -- 18.6 25.2 35.8 -13.7 -25.5 -- -29.1 6.0 -36.0 -29.8 -81.6 -16.3 -24.3 -- -19.2 -21.4 -35.5 -22.5 -34.9 -- -18.2 -22.8 -37.3 32.9 14.1 -- 5.5 21.4 -19.5 18.4 -45.5 34.9 __ jb -- 4.5 -3.2 2.6 -15.0 -7.3 -- 7.4 10.5 1.3 - 1032 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY W E I G H T GAINS (grams) OF Px FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 646638 646559 646598a 646561 646573a * 646504 646587a 646631a 646529 646603 646554a 646579 646564a 646672 646584a 646543 646596 646558a 646670a 646553 0-7 7-14 14-21 0-21 2.7 3.2 -- 9.7 -- 28.4 -- -- -1.6 34.9 -- 18.7 -- 9.0 -- -- b 13.5 -- -- 3.0 7.2 8.6 -- 2.6 -- 37.7 -- -- 8.0 -11.9 -- 16.6 -- 1.2 -- 11.6 25.4 -- -- 13.5 -12.3 -26.4 -- -20.5 -- -8.7 -- -- -6.3 6.0 -- -53.0 -- -12.4 -- -15.8 -12.0 -- -- -86.7 -2.4 -14.6 -- -8.2 -- 57.4 -- -- 0.1 29.0 -- -17.7 -- -2.2 -- -- b 26.9 -- -- -70.2 - 1033 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY WE I G H T GAINS (grams) OF Px FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 646547 646666a 646607 646524a 646600 646648 646594 646546 646661a 646671 646521 646590a 646645 646555a 646605a 646589a 646615 646527a 646647 646675a 0-7 7-14 14-21 0-21 21.6 -- 4.1 -- 30.9 32.8 15.0 24.2 -- 1.2 45.3 -- 34.5 -- -- -- -16.0 -- 22.4 -- -4.6 7.6 24.9 3.2 -11.1 25.5 15.0 23.8 20.5 -14.1 10.4 -25.8 -3.6 -18.2 -39.1 18.9 -13.2 12.0 -2.6 -3.6 44.4 -20.8 -8.8 8.1 37.6 -3.1 22.8 36.5 28.2 66.5 51.4 14.3 12.0 - 1034 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T G A I N S (grams) O F Pi F E M A L E R A T S D U R I N G L A C T A T I O N GROUP: VIII-0 DOSE: 500 MG/KG/DAY LACTATION DAYS : ANIMAL NUMBER 646662 646583a 646623 646619 646539 646628a 646616a 646563a 646641 646572 646512 646566 646570a 646602 646582a 646655 646663 646640a 646574 646532 0-7 7-14 14-21 0-21 27.0 -- -8.3 -4.7 -1.8 -- -- -- 22.6 5.2 23.5 32.6 -- 28.4 -- 16.1 19.7 -- 37.4 30.2 3.1 -- 28.5 ,10.9 15.9 -- -- -- 7.8 4.4 28.1 -0.5 -- -5.1 -- 6.0 20.3 -- -7.1 -20.7 -4.0 -- 1.5 4.8 17.2 -- -- -- -2.1 4.8 0.3 -0.7 -- -16.5 -- -28.5 4.1 -- 1.6 6.6 26.1 ___ 21.7 11.0 31.3 -- -- ___ 28.3 14.4 51.9 31.4 ___ 6.8 -- -6.4 44.1 -- 31.9 16.1 - 1035 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX U REPRODUCTIVE TOXICOLOGY INDIVIDUAL DAILY FOOD CONSUMPTION BY P, FEMALE RATS DURING GESTATION - 1036 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 REPRODUCTIVE TOXICOLOGY INDIVIDUAL DAILY FOOD CONSUMPTION BY Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a No litter was delivered; data were excluded from statistical analysis. b No gestation data were collected since no copulation plug was observed; however a litter was delivered. ` c No gestation data were collected since no copulation plug was observed; no litter was delivered. d Start of gestation miscalculated; data were excluded from statistical analysis. e No litter observed; however, implantation sites were present at necropsy. Data were excluded from statistical analysis. Abbreviations -- = No Data - 1037 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L D A I L Y F O O D C O N S U M P T I O N (grams) B Y Pi F E M A L E R A T S DURING GESTATION GROUP: II-O DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 646653 646575 646585a 646622 646550 646526 646503 646644 646604 646651 646552a 646606 646557 646591 646544 646646 646520a 646569 646654 646668 O 1 7-14 14-21 0-21 26.1 19.5 21.0 25.8 25.0 27.5 25.3 -- 24.5 24.9 19.1 21.8 24.9 24.5 29.9 27.5 21.0 26.1 25.3 24.9 28.5 30.4 19.1 28.9 27.1 26.1 27.0 -- 27.5 23.7 21.1 23.6 29.0 20.7 32.7 29.4 22.1 28.0 25.4 27.4 31.0 29.3 20.0 17.0 24.7 27.8 27.0 -- 28.2 24.6 21.1 23.4 28.5 29.3 30.1 31.3 21.7 29.5 26.9 27.7 28.5 26.4 20.0 23.9 25.6 27.1 26.4 -- 26.7 24.4 20.4 23.0 27.5 24.9 30.9 29.4 21.6 27.9 25.9 26.7 - 1038 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL D A I L Y FOOD CONSU M P T I O N (grams) BY P1 FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 646638 646559 646598a 646561 646573a 646504 646587a 646631a 646529 646603 646554a 646579 646564a 646672 646584a 646543 646596 646558a 646670a 646553 0-7 7-14 14-21 0-21 25.4 25.5 27.0 27.7 27.4 21.9 19.5 25.4 23.3 9.6 21.6 25.5 21.3 27.4 6.6 22.2 23.8 22.9 22.8 31.5 30.6 25.0 26.5 27.7 28.2 22.9 19.9 25.6 25.7 24.6 21.3 26.2 20.0 29.1 24.6 37.3 25.5 20.1 19.7 27.4 32.3 29.0 25.0 28.3 24.3 23.8 18.4 26.0 27.8 24.1 12.0 26.2 18.5 30.2 18.5 27.0 26.0 20.2 20.1 30.9 29.4 26.5 26.1 27.9 26.6 22.9 19.3 25.7 25.6 19.4 18.3 26.0 19.9 28.9 16.6 28.8 25.1 21.1 20.9 29.9 - 1039 - Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Px FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 646547 646666a 646607 646524e 646600 646648 646594 646546 646661a 646671 646521 646590a 646645 646555a 646605a 646589a 646615 646527a 646647 646675a 0-7 7-14 14-21 0-21 28.7 24.0 29.2 -- 26.1 22.2 25.4 18.2 26.3 25.6 23.3 22.8 24.3 27.3 26.0 18.2 24.5 22.1 22.6 20.6 31.1 22.6 28.7 -- 26.6 22.4 28.6 24.5 23.7 27.5 23.8 24.9 25.1 25.3 26.2 20.1 27.6 20.1 23.4 22.8 36.0 25.0 34.0 -- 28.3 27.3 33.3 28.0 23.1 29.5 24.3 19.9 27.5 18.0 20.0 25.2 31.2 20.0 7.6 23.3 32.0 23.9 30.7 -- 27.0 23.9 29.1 23.6 24.4 27.5 23.8 22.5 25.6 23.5 24.1 21.2 27.8 20.7 17.8 22.2 - 1040 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Px FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY GESTATION DAYS : ANIMAL NUMBER 646662 646583a 646623 646619 646539 646628a 646616a 646563a 646641 646572 646512 646566 646570a 646602 646582a 646655 646663^ 646640e 646574 646532 0-7 7-14 14-21 0-21 18.3 21.0 25.5 27.0 21.7 25.5 25.3 22.9 26.5 22.1 23.0 18.6 17.9 25.6 19.3 19.3 24.9 25.5 26.8 26.4 21.3 23.5 28.5 30.9 28.4 26.4 4.8 22.3 27.4 22.4 20.7 25.5 20.2 25.8 21.6 25.4 24.3 28.3 31.2 31.4 22.8 20.9 28.7 32.4 18.5 24.3 23.0 36.6 32.3 24.7 21.0 28.6 26.5 27.5 20.0 29.7 -- 10.0 31.5 34.5 20.8 21.8 27.6 30.1 22.9 25.4 17.7 27.2 28.7 23.1 21.6 24.3 21.5 26.3 20.3 24.8 -- 21.3 29.9 30.7 - 1041 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 APPENDIX V REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN P, MALE RATS - 1042- Company Sanitized. Does not contain TSCA CBt H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Px MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 646328 646479 646470 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 102 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 102 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 102 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 102 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 102 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 103 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 103 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 103 DISCHARGE NOSE RED DISCHARGE MOUTH RED SACRIFICED BY DESIGN TEST DAY 103 ALOPECIA RIGHT FRONT L E G (S ) SACRIFICED BY DESIGN TEST DAY 103 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 104 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 104 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 104 FIRST DAY LAST DAY OBSERVED OBSERVED 78 98 78 78 84 103 - 1043 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646461 646480 646383 646445 646358 646425 646408 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 104 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 104 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 105 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 105 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 105 DISCHARGE EYE(S ) RED STAINED RIGHT EYE(S ) BROWN SACRIFICED BY DESIGN TEST DAY 105 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 105 FIRST DAY LAST DAY OBSERVED OBSERVED - 1044- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Px MALE RATS GROUP: III-O DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646378 646483 646363 646334 646493 646404 646415 646410 646340 646354 646467 646381 646342 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 102 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 102 * NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 102 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 102 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 102 SALIVATION SACRIFICED BY DESIGN TEST DAY 103 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 103 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 103 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 103 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 103 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 103 SALIVATION SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 104 SALIVATION SACRIFICED BY DESIGN TEST DAY 104 FIRST DAY LAST DAY OBSERVED OBSERVED 95 95 84 89 95 95 100 100 100 100 -1045- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Px MALE RATS GROUP: III-O DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 646450 646326 646377 646478 646350 646333 646486 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 104 SALIVATION SACRIFICED BY DESIGN TEST DAY 104 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 105 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 105 ALOPECIA BOTH FRONT LEG(S ) SACRIFICED BY DESIGN TEST DAY 105 SALIVATION SACRIFICED BY DESIGN TEST DAY 105 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 105 100 100 84 105 100 100 - 1046 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646353 646341 646356 646330 646499 646400 646417 646338 646394 646387 646447 SALIVATION SACRIFICED BY DESIGN TEST DAY 102 ALOPECIA BOTH FRONT L E G (S ) ALOPECIA BOTH FRONT PAW(S) SALIVATION SACRIFICED BY DESIGN TEST DAY 102 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 102 SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 102 ALOPECIA BOTH FRONT LEG(S ) ALOPECIA RIGHT FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 102 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 103 SALIVATION SACRIFICED BY DESIGN TEST DAY 103 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 103 SALIVATION SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 103 SALIVATION SACRIFICED BY DESIGN TEST DAY 103 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 104 FIRST DAY LAST DAY OBSERVED OBSERVED 100 100 84 84 100 * 102 102 100 90 90 101 101 84 102 84 102 84 103 100 100 79 90 92 96 100 102 101 101 - 1047 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Pj. MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646336 646366 646496 646375 646465 646390 646429 646476 646348 SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 104 SALIVATION SACRIFICED BY DESIGN TEST DAY 104 SALIVATION SACRIFICED BY DESIGN TEST DAY 104 SALIVATION SACRIFICED BY DESIGN TEST DAY 104 SALIVATION SACRIFICED BY DESIGN TEST DAY 105 SALIVATION SACRIFICED BY DESIGN TEST DAY 105 SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 105 SALIVATION SACRIFICED BY DESIGN TEST DAY 105 SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 105 FIRST DAY LAST DAY OBSERVED OBSERVED 89 89 100 100 85 85 89 ' 98 96 99 98 98 92 95 81 95 101 101 89 91 83 89 99 99 - 1048 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Pj. MALE RATS GROUP: VII-0 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 646382 646406 646491 646351 646405 646418 646362 646497 646401 646498 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 102 SALIVATION SACRIFICED BY DESIGN TEST DAY 102 SALIVATION SACRIFICED BY DESIGN TEST DAY 102 SALIVATION SACRIFICED BY DESIGN TEST DAY 102 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 102 SALIVATION SACRIFICED BY DESIGN TEST DAY 103 ALOPECIA INGUEN ALOPECIA PERINEUM SALIVATION SACRIFICED BY DESIGN TEST DAY 103 STAINED INGUEN YELLOW STAINED PERINEUM YELLOW SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 103 SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 103 ALOPECIA RIGHT FRONT LEG(S) ALOPECIA RIGHT FRONT PAW(S) ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT L E G (S ) STAINED PERINEUM YELLOW SACRIFICED BY DESIGN TEST DAY 103 97 97 99 99 78 100 99 99 81 103 81 103 81 84 78 96 78 98 78 82 96 96 78 89 92 102 84 84 84 84 91 103 91 103 98 103 - 1049- Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Px MALE RATS GROUP: VII-0 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646386 646332 646441 646452 646365 646393 646359 646451 SALIVATION SALIVATION STAINED PERINEUM YELLOW SACRIFICED BY DESIGN TEST DAY 104 SALIVATION SALIVATION SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 104 SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 104 SALIVATION SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 104 STAINED PERINEUM YELLOW SACRIFICED BY DESIGN TEST DAY 104 SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 105 ALOPECIA BOTH FRONT LEG(S ) ALOPECIA BOTH FRONT PAW(S } SALIVATION SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 105 SALIVATION SALIVATION SALIVATION SACRIFICED BY DESIGN TEST DAY 105 FIRST DAY LAST DAY OBSERVED OBSERVED 89 89 102 102 104 104 > 80 80 90 90 95 95 99 99 85 89 98 102 82 82 85 85 99 99 91 104 82 82 92 98 84 90 84 105 84 90 92 96 99 104 89 89 96 96 100 100 - 1050 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX W REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING GESTATION - 1051 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Pj FEMALE RATS DURING GESTATION EXPLANATORY NOTES Note This appendix includes only clinical observations from rats with copulation plug observed. Footnotes a Copulation plug observed but no litter delivered. b Delivered a litter on Day 16G. - 1052 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S I N Pi F E M A L E R A T S D U R I N G G E S T A T I O N GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646653 646575 646585a 646622 646550 646526 646503 646604 646651 646552a 646606 646557 646591 646544 646646 646520a 646569 646654 646668 DISCHARGE LEFT E Y E (S ) RED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT LE(S) ALOPECIA BOTH FRONT PAW(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA LEFT FRONT L E G (S) ALOPECIA BOTH FRONT L E G (S ) NO ABNORMALITIES DETECTED ALOPECIA BACK NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED FIRST DAY OBSERVED LAST DAY OBSERVED 7 21 0 21 0 21 00 7 21 07 - 1053 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S I N Pi F E M A L E R A T S D U R I N G G E S T A T I O N GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646638 646559 646598a 646561 6465733 646504 6465873 6466313 646529 646603 6465543 646579 6465643 646672 6465843 646543 646596 6465583 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED STAINED PERINEUM YELLOW NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT PAW(S) NO ABNORMALITIES DETECTED ALOPECIA RIGHT FRONT L E G (S ) ALOPECIA RIGHT FRONT PAW(S) NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT PAW(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT LEG(S ) ALOPECIA BOTH FRONT PAW(S) ALOPECIA RIGHT SIDE(S) NO ABNORMALITIES DETECTED FIRST DAY OBSERVED LAST DAY OBSERVED 00 21 21 0 21 0 21 0 21 0 21 0 21 21 21 - 1054 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S I N Pi F E M A L E R A T S D U R I N G G E S T A T I O N GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 646670a 646553 ALOPECIA BOTH FRONT L E G (S) STAINED PERINEUM YELLOW ALOPECIA BOTH FRONT PAW(S) ALOPECIA RIGHT FRONT LEG(S ) ALOPECIA RIGHT FRONT PAW(S) ALOPECIA BOTH FRONT PAW(S) 0 7 18 0 0 1 18 21 7 21 14 14 21 - 1055 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Px FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 646547 646666a 646607 646600 646648 646594 646546 6466613 646671 646521 6465903 646645 6465553 6466053 6465893 646615 6465273 646647 6466753 SALIVATION NO ABNORMALITIES DETECTED SALIVATION SALIVATION SALIVATION SALIVATION NO ABNORMALITIES DETECTED ALOPECIA BOTH HIND QUARTERS ALOPECIA RIGHT SIDE{S) SALIVATION STAINED PERINEUM BROWN ALOPECIA BOTH FRONT LEG(S ) SALIVATION SALIVATION NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED SALIVATION SALIVATION SALIVATION SALIVATION ALOPECIA BOTH HIND QUARTERS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 27 44 67 55 18 18 18 21 18 21 15 15 14 14 0 21 55 15 18 55 16 16 16 16 47 14 21 - 1056 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S I N Pj. F E M A L E R A T S D U R I N G G E S T A T I O N GROUP: VIII-0 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646662 6465833 646623 646619 646539 646628a 6466163 6465633 646641 646572 646512 646566 6465703 SALIVATION NO ABNORMALITIES DETECTED SALIVATION NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED SALIVATION STAINED PERINEUM YELLOW SALIVATION SALIVATION SALIVATION NO ABNORMALITIES DETECTED ALOPECIA ABDOMEN ALOPECIA CHEST ALOPECIA UNDERBODY ALOPECIA BOTH HIND QUARTERS ALOPECIA BOTH SIDE(S) ALOPECIA BOTH REAR LEG(S ) ALOPECIA ABDOMEN ALOPECIA BOTH HIND QUARTERS ALOPECIA PERINEUM ALOPECIA BOTH FRONT L E G (S ) ALOPECIA BOTH SIDE(S) NO ABNORMALITIES DETECTED ALOPECIA RIGHT SIDE(S) ALOPECIA BOTH FRONT PAW(S) ALOPECIA ABDOMEN FIRST DAY OBSERVED LAST DAY OBSERVED 66 16 17 15 19 18 19 5 11 16 16 19 19 07 07 14 21 14 21 18 21 0 21 0 21 0 21 7 21 14 21 14 21 18 21 18 21 21 21 - 1057 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Px FEMALE RATS DURING GESTATION GROUP : VI11-0 DOSE : 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 646602 646582a 646655 646663-k 646640a 646574 646532 ALOPECIA ABDOMEN ALOPECIA BOTH HIND QUARTERS ALOPECIA LEFT SHOULDER(S) SALIVATION SALIVATION STAINED PERINEUM YELLOW ALOPECIA BOTH FRONT PAW(S) STAINED PERINEUM YELLOW SALIVATION STAINED PERINEUM YELLOW STAINED PERINEUM YELLOW COLORED DISCHARGE VAGINAL OPENING RED STAINED CAGEBOARD RED STAINED VAGINAL OPENING BROWN COLORED DISCHARGE VAGINAL OPENING RED ALOPECIA RIGHT HIND QUARTERS ALOPECIA BOTH HIND QUARTERS ALOPECIA PERINEUM ALOPECIA UNDERBODY ALOPECIA BOTH HIND QUARTERS ALOPECIA BOTH SIDE(S) ALOPECIA BOTH FRONT L E G (S ) ALOPECIA BOTH FRONT PAW(S) 0 0 0 4 15 0 0' 7 0 14 0 16 16 18 21 7 14 14 0 0 0 0 0 21 21 21 4 17 21 0 18 0 14 16 16 16 18 21 7 21 21 21 21 21 21 21 - 1058 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 APPENDIX X REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING LACTATION - 1059 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING LACTATION EXPLANATORY NOTES Note This appendix includes clinical observations from lactating rats only. Footnote a No copulation plug was observed, however, a litter was delivered. - 1060 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Px FEMALE RATS DURING LACTATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646653 646575 646622 646550 646526 646503 646644s 646604 646651 646606 646557 646591 646544 DISCHARGE LEFT EYE (S ) RED STAINED LEFT EYE(S ) BROWN SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 ALOPECIA BOTH FRONT L E G (S ) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 125 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 127 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA BOTH FRONT LEG(S ) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY.DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 FIRST DAY LAST DAY OBSERVED OBSERVED 0 14 21 21 07 0 21 0 21 7 21 - 1061 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646646 646569 646654 646668 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 FIRST DAY LAST DAY OBSERVED OBSERVED - 1062 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Px FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646638 646559 646561 646504 646529 646603 646579 646672 646543 646596 646553 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 117 MASS 1 2.0 cm LEFT SHOULDER(S) SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH FRONT PAW(S) ALOPECIA RIGHT SIDE(S) ALOPECIA RIGHT REAR L E G (S ) SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S ) SACRIFICED BY DESIGN TEST DAY 122 FIRST DAY LAST DAY OBSERVED OBSERVED 0 21 0 21 2 21 0 21 0 21 00 7 21 0 21 21 21 - 1063 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646547 646607 + 646600 646648 646594 646546 646671 646521 646645 646615 646647 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA BOTH HIND QUARTERS ALOPECIA RIGHT SIDE(S) SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 ALOPECIA BOTH FRONT LEG(S ) ALOPECIA BOTH REAR LEG(S ) ALOPECIA LEFT SIDE(S) SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA BOTH HIND QUARTERS ALOPECIA ABDOMEN SALIVATION SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 124 FIRST DAY LAST DAY OBSERVED OBSERVED 0 21 0 21 0 21 0 21 14 21 0 21 05 55 - 1064 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION 646662 646623 646619 646539 646641 646572 646512 646566 646602 646655 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA UNDERBODY ALOPECIA BOTH HIND QUARTERS ALOPECIA BOTH SIDE(S) SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA BOTH REAR L E G (S ) ALOPECIA ABDOMEN ALOPECIA BOTH HIND QUARTERS ALOPECIA PERINEUM ALOPECIA BOTH FRONT LEG{S ) ALOPECIA BOTH SIDE(S) SACRIFICED BY DESIGN TEST DAY 117 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 ALOPECIA ABDOMEN ALOPECIA BOTH HIND QUARTERS ALOPECIA LEFT SHOULDER(S) STAINED PERINEUM YELLOW SACRIFICED BY DESIGN TEST DAY 119 STAINED PERINEUM YELLOW SACRIFICED BY DESIGN TEST DAY 121 FIRST DAY LAST DAY OBSERVED OBSERVED 0 21 0 21 0 21 0 21 0 21 0 21 0 21 0 21 0 21 0 21 0 21 0 21 21 21 07 - 1065 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Pj. FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 646663 646532 COLORED DISCHARGE VAGINAL OPENING RED SACRIFICED BY DESIGN TEST DAY 121 ALOPECIA UNDERBODY ALOPECIA BOTH HIND QUARTERS ALOPECIA BOTH SIDE(S) ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 122 00 0 21 0 21 0 21 0 21 0 21 - 1066 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX Y INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION IN P! FEMALE RATS - 1067 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION IN P, FEMALE RATS EXPLANATORY NOTES Footnotes: a Copulation plug detected, but animal did not deliver a litter. b Mean cycle length was not calculable due to insufficient data. c No evidence of copulation was found; but animal did deliver a litter. Animal was excluded from group summary data. d No precoital interval could be calculated since no evidence of copulation was found. e No evidence of copulation was found; animal did not deliver a litter. / Animal delivered a litter on Day 16G. Animal was excluded from statistical analyses. Abbreviations: = No Data - 1068 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP II-O: 0 MG/KG/DAY A N IM A L N U M BER 646653 6 4 6 (5 7 5 6465853 646622 646550 646526 646503 646644e 646604 646651 6465523 646606 646557 646591 646544 646646 6465203 646569 646654 646668 NUMBER OF DAYS OF DATA C O LLE C T IO N PERC EN T OF DAYS IN ESTRUS PERCEN T OF DAYS IN D IE S T R U S PERC EN T OF D AYS IN PRO ESTRUS M EAN C Y C LE LEN G TH (d a y s) P R E C O IT A L IN T E R V A L (d a y s) 22 23% 68% 9% 4 . 6 7 2 22 36% 59% 5% 4 . 5 0 2 21 33% 67% 0% 4 . 0 0 1 29 14% 79% 7% 5 . 5 0 9 30 53% 43% 3 % ______b 1 0 21 52% 33% 14% _____ b 1 21 19% 67% 14% 4 .0 0 1 35 20% 74% 6% 5 .3 3 ------d 26 23% 69% 8% 4 . 0 0 6 21 24% 76% 0% 4 . 0 0 1 21 33% 57% ' 10% 4 .0 0 1 23 22% 65% 13% 4 .0 0 3 23 22% 78% 0% 4 . 0 0 3 24 25% 58% 17% 4 .7 5 4 21 100% 0% 0% _ _ _ b 1 22 23% 73% 5% 4 . 0 0 2 26 27% 69% 4% 4 . 0 0 6 24 29% 58% 13% 4 .0 0 4 24 33% 58% 8% 4 . 0 0 4 23 22% 70% 9% 5 . 0 0 3 - 1069 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP IV-0 : 25 MG/KG/DAY ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 646638 646559 646598s 646561 646573s 646504 646587s 646631s 646529 646603 646554s 646579 646564s 646672 646584s 646543 646596 646558s 646670s 646553 22 21 31 21 21 22 21 26 22 22 29 21 26 22 24 21 22 21 22 26 32% 33% 55% 24% 81% 23% 29% 23% 9% 23% 14% 33% 19% 14% 25% 95% 23% 24% 18% 27% 59% 62% 32% 71% 14% 73% 57% 73% 82% 68% 83% 48% 69% 73% 71% 0% 59% 57% 68% 65% 9% 5% 13% 5% 5% 5% 14% 4% 9% 9% 3% 19% 12% 14% 4% 5% 18% 19% 14% 8% 4 .0 0 5 .0 0 4 .6 7 4 .3 3 ------ Jb 4 .0 0 6 .3 3 5 .2 5 4 .6 7 4 .0 0 5 .7 5 4 .0 0 5 .0 0 3 .7 5 4 .0 0 ___b 5 .0 0 5 .0 0 5 .0 0 4 .5 0 2 1 ' 11 1 1 2 2 6 2 3 9 1 6 2 4 1 2 1 3 6 - 1070 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 ANIMAL NUMBER 646547 646666a 646607 646524e 646600 646648 646594 646546 6466613 646671 646521 6465903 646645 6465553 6466053 6465893 646615 6465273 646647 6466753 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP VI-0: 100 MG/KG/DAY NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 24 29% 24 1 21% 23 22% 35 66% 22 27% 21 19% 22 27% 22 32% 20 50% 24 29% 24 25% 21 43% 21 38% 21 100% 21 10% 20 35% 24 21% 24 25% 27 26% 26 38% 58% 75% 70% 34% 68% 71% 64% 68% 45% 67% 71% 57% 57% 0% 90% 45% 71% 75% 70% 46% 13% 4% 9% 0% 5% 10% 9% 0% 5% 4% 4% 0% 5% 0% 0% 20% 8% 0% 4% 15% 4 .5 0 3 .6 0 4 .2 5 6 .6 7 4 .2 5 5 .0 0 4 .0 0 4 .2 5 6 .0 0 4 .7 5 4 .0 0 8 .0 0 6 .0 0 --b ______b 4 .0 0 5 .0 0 4 .2 5 5 .0 0 4 .5 0 4 4 3 ______d 2 1 2 2 1 4 4 1 1 1 1 1 4 4 7 6 - 1071 - Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 ANIMAL NUMBER 646662 646583s 646623 646619 646539 646628s 646616s 646563s 646641 646572 646512 646566 646570s 646602 646582s 646655 646663-f 646640s 646574 646532 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION G R O U P V I I I -0 : 500 MG / K G / D A Y NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 22 23% 68% 9% 5 . 0 0 2 22 23% 64% 14% 5 .0 0 2 21 38% 57% 5% 4 . 6 7 1 21 29% 57% 14% 5 .0 0 1 21 24% 62% 14% 5 .3 3 1 20 25% 60% 15% 5 .6 7 1 33 58% 39% 3% 5 . 6 7 14 21 14% 67% 19% 4 .3 3 1 21 24% 57% 19% 5 .0 0 1 21 29% 62% 10% 5 .3 3 1 21 29% 57% 14% 5 .3 3 1 22 23% 64% 14% 4 .2 5 2 21 76% 14% 1 0 % ___> 1 22 14% 73% 14% 4 .0 0 2 25 32% 68% 0% 5 . 0 0 6 24 25% 67% 8% 4 . 7 5 4 31 23% 77% 0% 4 . 0 0 11 29 21% 79% 0% 3 . 8 0 9 24 25% 71% 4% 4 . 0 0 4 24 29% 63% 8% 5 . 0 0 4 - 1072 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX Z INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION IN P, FEMALE RATS - 1073 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION IN Pi FEMALE RATS EXPLANATORY NOTES Notes: Test Days 52-72 = Premating Test Days 72-86 = Cohabitation period Abbreviations: D = Diestrus E = Estrus P = Proestrus X = No sample or stage could not be defined from sample. Footnotes: a No evidence of copulation was found; animal was pregnant. b No evidence of copulation was found; animal was not pregnant. c Two females were cohoused one day late (day 77) with two males that had already mated. - 1074 - Company Sanitized. Does not contain TSCA CBI )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) DuPont-5990 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP II-O: 0 MG/KG/DAY TEST DAYS 7 58 5 9 160 61 62 63 64 65 66 6 7 168|69|70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 TT in I d ""d"; "d " ""d51"I"dTi 1 D d ]HI 1 I ni"d ""d ""d" "d" "d " D D D D "d ""d" "d I 1d1 ~ \ 7V v a ni'.: D [ d " D D r- E Company Sanitized. Does not contain TSCA CBI - 1075 - ))) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________________________________ DuPont-5990 ANIMAL INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP IV-0 : 25 MG/KG/DAY TEST DAYS 71TT72 IT D D TTTT D 74 75 76 77 78 79 80 81 82 83 84 85 86 D D Da w D ifi D D D lil'iiPI D DDDD Company Sanitized. Does not contain TSCA CBI - 1076 - )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) DuPont-5990 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP VI-0: 100 MG/KG/DAY TEST DAYS 68 69 70 "D5"JFD. FD J72~ 73 74 75 76 77 78 79 80 81 82 83 84 85 86 HD i l F|D D D FF T - sa F H ; ? ' ? " : nr D D 1T w. 3FI 3F FF w je FFF [] Fd F F FF I F d ]F F F! D ~ D D Company Sanitized. Does not contain TSCA CBI - 1077 - )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________________________________________________ DuPont-5990 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP VIII-0 : 500 MG/KG/DAY TEST DAYS [7 3 174 75 76 77 78 79 80 81 82 83 84 85 86 r il D 3 M:: TT D~ pm DF H - TT D TT IT TT D D T TT"5* TT IT 2C if "5* IT z :: D d "IT Company Sanitized. Does not contain TSCA CBI - 1078 - H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 Y APPENDIX AA REPRODUCTIVE TOXICOLOGY INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN Pi MALE RATS - 1079 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN P 1 MALE RATS GROUP 1-0 0 MG/KG/DAY Animal Number Percent Motile 646490 646378 646353 646382 646440 646483 646341 646406 646424 646363 95 100 94 93 98 96 97 94 97 93 GROUP III-O 25 MG/KG/DAY Animal Number Percent Motile 646356 646491 646402 646334 646330 646351 646392 646493 646499 646405 97 92 89 90 94 89 97 95 95 92 GROUP V-0 100 MG/KG/DAY Animal Number Percent Motile 646473 646404 646400 646418 646395 646415 646417 646362 646352 646410 87 86 97 95 97 94 95 92 81 89 GROUP VII-0 500 MG/KG/DAY Animal Number Percent Motile 646338 646497 646357 646340 646394 646401 646409 646354 646387 646498 86 95 95 83 89 84 92 91 90 85 - 1080 - Company Sanitized. Does not contain TSCA C8I H90--2D4a7y68G: aSvuagbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 APPENDIX BB INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Pi MALE RATS -1081 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P 1 MALE RATS GROUP 1-0 : 0 MG/KG/DAY Animal Number 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 Total Tail Head Tail & Head Percent Normal Abnormal Abnormal Abnormal Normal 196 2 195 1 197 0 199 1 197 0 196 2 197 0 196 1 197 3 196 0 2 4 3 0 3 2 3 3 0 4 0 98.0 0 97.5 0 98.5 0 99.5 0 98.5 0 98.0 0 98.5 0 98.0 0 98.5 0 98.0 Animal Number 646378 646483 646363 646334 646493 646404 646415 646410 646340 646354 GROUP III-O:: 25 MG/KG/DAY Total Tail Head Tail & Head Percent Normal Abnormal Abnormal Abnormal Normal 200 0 200 0 197 0 193 7 198 0 196 1 196 0 199 0 191 1 195 0 0 0 3 0 2 3 4 1 8 5 0 100.0 0 100.0 0 98.5 0 96.5 0 99.0 0 98.0 0 98.0 0 99.5 0 95.5 0 97.5 - 1082 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 I N D I V I D U A L A N I M A L S P E R M M O R P H O L O G Y D A T A I N Pi M A L E R A T S GROUP V - 0 : 100 MG/KG/DAY Animal Number 646353 646341 646356 646330 646499 646400 646417 646338 646394 646387 Total Tail Head Tail & Head Percent Normal Abnormal Abnormal Abnormal Normal 197 0 198 1 198 1 196 1 199 1 196 1 200 0 198 0 197 0 198 1 3 1 1 3 0 3 0 2 3 1 0 98.5 0 99.0 0 99.0 0 98.0 0 99.5 0 98.0 0 100.0 0 99.0 0 98.5 0 99.0 Animal Number 646382 646406 646491 646351 646405 646418 646362 646497 646401 646498 GROUP VII-0 : 500 MG/KG/DAY Total Tail Head Tail & Head Percent Normal Abnormal Abnormal Abnormal Normal 193 2 199 0 195 2 197 0 197 0 195 1 196 0 185 0 199 0 198 0 5 1 3 3 3 4 4 15 1 2 0 96.5 0 99.5 0 97.5 0 98.5 0 98.5 0 97.5 0 98.0 0 92.5 0 99.5 0 99.0 - 1083 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 APPENDIX CC INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS IN P, MALE RATS - 1084 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (Millions) IN Px MALE RATS Animal Number 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 Animal Number 646378 646483 646363 646334 646493 646404 646415 646410 646340 646354 GROUP 1-0 : 0 MG/KG/DAY Epididymal Sperm Per cauda Per g cauda Testicular Spermatids Per testis Per g testis 300.4 266.5 321.5 322.7 372.9 319.2 327.3 284.1 305.1 364.7 1324.1 1170.5 1074.1 1181.0 1263.3 1228.4 1064.8 1132.2 1078.5 1285.2 149.1 115.2 129.8 121.0 122.2 132.7 124.5 126.9 119.8 123.4 91.5 82.6 86.7 85.4 81.4 85.2 80.0 83.9 76.2 79.9 GROUP III-O: 25 MG/KG/DAY Epididymal Sperm Per cauda Per g cauda Testicular Spermatids Per testis Per g testis 292.3 288.8 281.7 295.8 274.7 281.7 264.2 295.8 238.5 274.7 1107.0 836.0 891.8 893.3 1037.1 1012.7 916.1 1275.4 986.7 835.5 142.6 140.3 114.6 132.1 131.5 131.5 123.9 120.4 125.1 126.3 96.1 78.9 82.4 89.0 87.0 118.6 77.1 104.5 94.8 108.2 - 1085 - Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (Millions) IN Px MALE RATS Animal Number 646353 646341 646356 646330 646499 646400 646417 646338 646394 646387 Animal Number 646382 646406 646491 646351 646405 646418 646362 646497 646401 646498 GROUP V - 0 : 100 MG/KG/DAY Epididymal Sperm_______Testicular Spermatids Per cauda Per g Per testis Per g cauda testis 265.4 267.7 280.6 277.1 320.3 263.0 340.2 309.8 268.9 318.0 781.4 970.3 1023.2 1026.1 941.8 973.5 1132.1 1062.7 879.2 900.0 145.0 121.6 132.7 119.3 125.1 142.6 130.4 123.4 113.4 128.6 93.6 73.0 89.2 92.0 86.0 79.8 86.1 115.2 78.3 81.0 GROUP VII-0 : 500 MG/KG/DAY Epididymal Sperm Per cauda Per g cauda Testicular Spermatids Per testis Per g testis 258.4 277.1 258.4 289.9 301.6 282.9 244.3 316.8 275.9 288.8 1068.4 1159.2 835.3 1223.3 1136.8 1039.7 928.3 1320.0 882.3 1027.6 131.5 144.4 146.7 149.1 129.8 146.7 124.5 138.0 138.5 121.0 79.0 82.8 95.2 85.6 80.8 85.6 89.9 96.8 74.3 63.7 - 1086 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 t APPENDIX DD REPRODUCTIVE TOXICOLOGY INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION - 1087 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5990 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION EXPLANATORY NOTES Note Column labeled "Plug Observed" + indicates that a copulatory plug was observed indicates that no copulatory plug was observed Column labeled "Litter Produced" + indicates that a litter was produced indicates that no litter was produced Footnote a Because a copulatory plug was not observed, the start of gestation is unknown and, therefore, gestation length cannot be determined. b Start of gestation miscalculated; gestation length unknown. c No litter delivered, however, implantation sites were observed at necropsy. - 1088 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________ DuPont-5990 FEMALE ANIMAL# 646653 646575 646585 646622 646550 646526 646503 646644 646604 646651 646552 646606 646557 646591 646544 646646 646520 646569 646654 646668 I N D I V I D U A L M A T I N G D A T A A N D G E S T A T I O N L E N G T H : Pi G E N E R A T I O N GROUPS: 11-0,1-0 DOSE: 0 MG/KG/DAY MALE #1 ANIMAL# PLUG OBSERVED 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 646328 646479 646470 646461 646480 646383 646445 646358 646425 646408 1 + + + + + + + _ + + + + 4+ + + + + + MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + - + + + + + + + - + + + + - + + + GESTATION LENGTH(days) 23 23 22 23 23 23 __a 22 23 -- 22 23 22 23 22 -- 22 22 23 - 1089 - Company Sanitized. Does not contain TSCA CBI H90--2D4a76y8G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 FEMALE ANIMAL# 646638 646559 646598 646561 646573 646504 646587 646631 646529 646603 646554 646579 646564 646672 646584 646543 646596 646558 646670 646553 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pj. GENERATION GROUPS: IV-0,111-0 DOSE: 25 MG/KG/DAY MALE #1 ANIMAL# 646378 646483 646363 646334 646493 646404 646415 646410 646340 646354 646467 646381 646342 646450 646326 646377 646478 646350 646333 646486 PLUG OBSERVED + + + + + + + + + + + + + + + + + + + + MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + + + + - ~ + + + - + + + - - + GESTATION LENGTH(days) 22 23 -- 23 -- 22 --22 22 -- 22 -23 -- 23 22 -- -- 22 - 1090- Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 FEMALE ANIMAL# 646547 646666 646607 646524 646600 646648 646594 646546 646661 646671 646521 646590 646645 646555 646605 646589 646615 646527 646647 646675 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: VI-O.V-O DOSE: 100 MG/KG/DAY MALE #1 ANIMAL# 646353 646341 646356 646330 646499 646400 646417 646338 646394 646387 646447 646336 646366 646496 646375 646465 646390 646429 646476 646348 PLUG OBSERVED + + + - + + + + + + + + + + + + + + + MALE #2 ANIMAL# PLUG OBSERVED f LITTER PRODUCED + - + - + + + + - + _ +. - + - GESTATION LENGTH(days) 22 -23 -- 22 22 22 22 -- 23 23 -- 23 ---- 23 -- 23 -- -1091 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: VIII-0,VII-0 DOSE: 500 MG/KG/DAY FEMALE ANIMAL# 646662 646583 646623 646619 646539 646628 646616 646563 646641 646572 646512 646566 646570 646602 646582 646655 646663 646640 646574 646532 M ALE #1 A N IM A L# 646382 646406 646491 646351 646405 646418 646362 646497 646401 646498 646386 646332 646441 646452 646365 646393 646359 646451 646491 646351 PLUG O BSERV ED + + + + -f + + + + + + + + + + + + + + M ALE #2 A N IM A L# PLUG O BSERVED L IT T E R PR O D U C ED + + + + + + + + _ + + + + + G ES T A T IO N LE N G T H (d a y s) 23 -23 23 23 --- -23 23 22 23 -23 -- 23 16fa __c 23 23 - 1092- Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 APPENDIX EE REPRODUCTIVE TOXICOLOGY INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY - 1093 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5990 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY EXPLANATORY NOTES Footnotes a Number of pups bom exceeded the number of implantation sites counted; implantation efficiency cannot be determined. b Litter was counted before delivery was complete; number of pups bom unknown. Implantation efficiency cannot be determined. c No litter produced; therefore implantation efficiency cannot be determined. Abbreviations = No data - 1094 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: II-O DOSE: 0 MG/KG/DAY Animal Number Pups Born Number of Implantation Sites Implantation Efficiency 646653 646575 646622 646550 646526 646503 646644 646604 646651* 646606 646557 646591 646544 646646 646569 646654 646668 16 9 14 15 11 16 14 15 -- 15 12 14 13 18 19 13 15 17 12 17 18 13 11 15 15 16 16 12 15 14 16 20 14 19 94.1 75.0 82.4 83.3 84.6 __ a 93.3 100.0 -- 93.8 100.0 93.3 92.9 -- a 95.0 92.9 78.9 - 1095 - Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: IV-0 DOSE: 25 MG/KG/DAY Animal Number Pups Born Number of Implantation Sites Implantation Efficiency 646638 646559 646561 646504 646529 646603 646579 646672 646543* 646596 646553 18 13 7 14 12 18 15 13 -- 16 11 18 14 7 15 14 ` 19 16 14 8 17 13 100.0 92.9 100.0 93.3 85.7 94.7 93.8 92.9 -- 94.1 84.6 - 1096- Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: VI-0 DOSE: 100 MG/KG/DAY Animal Number Pups Born Number of Implantation Sites Implantation Efficiency 646547 646607 646600 646648 646594 '646546 646671 646521 646645 646615 646647 17 14 17 8 12 15 14 8 14 12 16 19 16 18 10 11 15 18 9 16 15 16 89.5 87.5 94.4 80.0 __ a 100.0 77.8 88.9 87.5 80.0 100.0 - 1097- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 I N D I V I D U A L IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: VIII-0 DOSE: 500 MG/KG/DAY Animal Number Pups Born Number of Implantation Sites Implantation Efficiency 646662 646623 646619 646539 646641 646572 646512 646566 646602 646655 646663 646640e 646574 646532 11 6 13 12 13 14 9 10 5 12 13 3 13 13 6 13 14 15 9 14 10 5 16 13 i1 7 14 84.6 100.0 100.0 85.7 86.7 __ a 64.3 100.0 100.0 75.0 100.0 42.9 92.9 - 1098 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 APPENDIX FF REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP SURVIVAL: F, GENERATION - 1099- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP SURVIVAL: Fi GENERATION EXPLANATORY NOTES Footnotes a No litter delivered. b Litter was counted before delivery was completed. c No litter observed; however, implantation sites were present at necropsy. DuPont-5990 - 1100Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER 646653 646575 646585a 646622 646550 646526 646503 646644 646604 646651 646552a 646606 646557 646591 646544 646646 646520a 646569 646654 646668 BORN 16 9 -- 14 15 11 16 14 15 -- 15 12 14 13 18 -- 19 13 15 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 D A Y 14 D A Y 21 16 9 -- 14 15 11 16 14 b15 __ -- 15 12 14 13 18 -- 19 13 15 14 9 -- 14 15 11 13 13 15 16 -- 15 12 14 13 18 -- 19 13 15 8 8 -- 8 8' 8 8 8 8 8 -- 8 8 8 8 8 -- 8 8 8 8 8 -- 8 8 8 8 8 8 8 -- 8 8 8 8 8 -- 8 8 8 8 8 -- 8 8 8 8 8 8 8 -- 8 8 8 8 8 -- 8 8 8 8 8 ______ 8 8 8 8 8 8 8 -- 8 8 8 8 8 ______ 8 8 8 - 1101 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER BORN 646653 646575 8 3 646585a -- 646622 t 6 646550 6 646526 8 646503 9 646644 1 646604 646651 b8 __ 646552a 646606 646557 646591 646544 646646 -- 4 6 10 5 10 646520a 646569 646654 646668 -- 12 8 8 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 D A Y 14 DAY 8 3 -- 6 6 8 9 1 b8 __ -- 4 6 10 5 10 -- 12 8 8 7 3 -- 6 6 8 8 1 8 6 -- 4 6 10 5 10 -- 12 8 8 4 3 -- 4 4 5 4 1 4 4 -- 4 4 4 4 4 -- 4 4 4 4 3 -- 4 4 5 4 1 4 4 -- 4 4 4 4 4 ____ 4 4 4 4 3 ____ 4 4 5 4 1 4 4 -- 4 4 4 4 4 -- 4 44 ' 4 3 ___ 4 4 5 4 1 4 4 ________ 4 4 4 4 4 ________ 4 4 4 -1102Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER 646653 646575 646585s 646622 646550 646526 646503 646644 646604 646651 646552s 646606 646557 646591 646544 646646 646520s 646569 646654 646668 BORN 8 6 -- 8 9 3 7 13 7 ___L -- 11 6 4 8 8 -- 7 5 7 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 8744 6 -- 6 -- 5 -- 5 ____ 8844 9944 3333 7 54 4 13 12 7 7 b7 7 4 4 __ 10 4 4 -- ---- -- 11 11 4 4 6644 4444 8844 8844 -- ---- -- 774 4 554 4 7 74 4 DAY 14 DAY 21 44 55 ____ ____ 44 44 33 44 77 44 44 ____ __ 44 44 44 44 44 -- ____ 44 44 44 -1103- Com pany Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER 646653 646575 646585^ 646622 646550 646526 646503 646644 646604 646651 6465523 646606 646557 646591 646544 646646 6465203 646569 646654 646668 INDIVIDUAL PUP SURVIVAL: F 1 GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 0.50 0.33 -- 0.43 0.40 0.73 0.56 0.07 b0.53 __ -- 0.27 0.50 0.71 0.38 0.56 -- 0.63 0.62 0.53 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 -- b100.0 -- 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 87.5 100.0 -- 100.0 100.0 100.0 81.3 92.9 b100.0 __ -- 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 - 1104- Company Sanitized. Does not contain T S C A C 8 I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 646653 646575 646585a 646622 646550 646526 646503 646644 646604 646651 646552s 646606 646557 646591 646544 646646 646520s 646569 646654 646668 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY % BORN ALIVE NUMBER OF MALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 100.0 __ Jb -- 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 87.5 100.0 -- 100.0 100.0 100.0 88.9 100.0 b100.0 __ -- 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 DuPont-5990 - 1105- Com pany Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 646653 646575 646585a 646622 646550 646526 646503 646644 646604 646651 646552s 646606 646557 646591 646544 646646 646520s 646569 646654 646668 INDIVIDUAL PUP SURVIVAL: F 1 GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY % BORN ALIVE NUMBER OF FEMALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 b100.0 __ -- 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 87.5 100.0 -- 100.0 100.0 100.0 71.4 92.3 b100.0 __ -- 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 -- 100.0 ' 100.0 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 100.0 100.0 -- 100.0 100.0 100.0 DuPont-5990 - 1106- Company Sanitized. Does not contain TSC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER 646638 646559 646598a 646561 646573a 646504 646587-a 646631-3 646529 646603 646554-a 646579 646564a 646672 646584-a 646543 646596 646558a 6466703 646553 BORN 18 13 -- Y7 14 -- -- 12 18 -- 15 -- 13 b-- __ 16 -- -- 11 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 18 13 -- 7 -- 14 -- -- 12 18 -- 15 -- 13 b-- __ 14 -- -- 11 18 11 -- 7 -- 14 -- -- 12 18 -- 15 -- 13 -- 8 14 -- -- 11 8 8 -- 7 -- 8 -- -- 8 8 -- 8 -- 8 -- 8 8 -- -- 8 8 8 -- 7 -- 8 -- -- 8 8 -- 8 -- 8 -- 8 8 -- -- 8 DAY 14 DAY 21 8 8 -- 7 ____ 8 -- ______ 8 8 -- 8 -- 8 -- 8 8 -- -- 8 8 8 -- 7 ____ 8 -- ______ 8 8 -- 8 -- 8 -- 8 8 -- __ 8 -1107- Com pany Sanitized. Does not contain T S C A CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER 646638 646559 646598s 646561 646573a 646504 646587a 646631a 646529 646603 646554a 646579 646564a 646672 646584a 646543 646596 646558a 646670s 646553 BORN 10 6 -- 6 -- 11 -- -- 9 11 -- 9 -- 5 -- ___L 9 -- -- 2 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 10 6 -- 6 -- 11 -- -- 9 11 -- 9 -- 5 b-- __ 9 -- -- 2 10 6 -- 6 -- 11 -- -- 9 11 -- 9 -- 5 -- 3 9 -- -- 2 4 4 -- 6 -- 5 -- -- 5 4 -- 4 -- 4 -- 3 4 -- -- 2 4 4 -- 6 -- 5 -- -- 5 4 -- 4 -- 4 -- 3 4 -- -- 2 4 4 -- 6 -- 5 -- -- 5 4 -- 4 -- 4 -- 3 4 -- -- 2 4 4 -- 6 -- 5 -- -- 5 4 -- 4 -- 4 -- 3 4 -- -- 2 -1108- Com pany Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER 646638 646559 646598a 646561 646573a 646504 646587a 6466313 646529 646603 6465543 646579 6465643 646672 6465843 646543 646596 6465583 6466703 646553 BORN 8 7 -- 1 -- 3 -- -- 3 7 -- 6 -- 8 -- b__ 7 -- -- 9 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 8844 7544 -------- 111 1 -- i-- -- -- 3333 -------- -------- 3333 7744 -------- 6644 -------- 8844 -------- 555 554 4 -------- -------- 9966 DAY 14 DAY 21 4 4 -- 1 -- 3 -- __ 3 4 -- 4 -- 4 -- . 5 4 -- -- 6 4 4 ___ 1 ___ 3 -- __ 3 4 -- 4 -- 4 -- 5 4 -- -- 6 -1109- Com pany Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER 646638 646559 646598s 646561 646573s 646504 646587s 646631s 646529 646603 646554s 646579 646564s 646672 646584s 646543 646596 646558s 646670s 646553 INDIVIDUAL PUP SURVIVAL: F3. GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 0.56 0.46 -- 0.86 -- 0.79 -- -- 0.75 0.61 -- 0.60 -- 0.38 -- __ jb 0.56 -- -- 0.18 100.0 100.0 -- 100.0 -- 100.0 -- -- 100.0 100.0 -- 100.0 -- 100.0 -- __ jb 87.5 -- -- 100.0 100.0 84.6 -- 100.0 -- 100.0 -- -- 100.0 100.0 -- 100.0 -- 100.0 -- ___b 100.0 -- -- 100.0 100.0 100.0 -- 100.0 -- 100.0 -- -- 100.0 100.0 -- 80.0 -- 100.0 -- 100.0 100.0 -- -- 100.0 - 1110 - Com pany Sanitized. Does not contain T SC A C 8 I H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ANIMAL NUMBER 646638 646559 646598s 646561 646573s 646504 646587s 646631s 646529 646603 646554s 646579 646564s 646672 646584s 646543 646596 646558s 646670s 646553 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY % BORN ALIVE NUMBER OF MALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 -- 100.0 -- 100.0 -- -- 100.0 100.0 -- 100.0 -- 100.0 -- 100.0 -- -- 100.0 100.0 100.0 -- 100.0 -- 100.0 -- -- 100.0 100.0 -- 100.0 -- 100.0 -- 100.0 -- -- 100.0 100.0 100.0 -- 100.0 * -- 100.0 -- -- 100.0 100.0 -- 100.0 -- 100.0 -- 100.0 100.0 -- -- 100.0 DuPont-5990 -m i - Com pany Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 646638 646559 6465983 646561 646573a 646504 6465873 6466313 646529 646603 6465543 646579 6465643 646672 6465843 646543 646596 6465583 6466703 646553 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY % BORN ALIVE NUMBER OF FEMALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 -- . 100.0 -- 100.0 -- -- 100.0 100.0 -- 100.0 -- 100.0 -- __ ib 71.4 -- -- 100.0 100.0 71.4 100.0 100.0 100.0 100.0 100.0 100.0 ---- b 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 66.7 100.0 100.0 100.0 100.0 DuPont-5990 -1112- Com pany Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER 646547 646666s 646607 646524s 646600 646648 646594 646546 646661s 646671 646521 646590s 646645 646555s 646605s 646589s 646615 646527s 646647 646675s BORN 17 -- 14 -- 17 8 12 15 -- 14 8 -- 14 -- -- -- 12 -- 16 -- INDIVIDUAL PUP SURVIVAL: F3. GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 17 -- 14 -- 17 8 12 15 -- 13 8 -- 12 -- -- -- 12 -- 16 -- 16 -- 14 -- 17 8 12 15 -- 13 8 -- 12 -- -- -- 12 -- 15 -- 8 -- 8 -- 8 8 8 8 -- 8 8 -- 8 -- -- -- 8 -- 8 -- 8 -- 5 -- 8 8 8 8 -- 8 8 -- 8 -- -- ______ 8 -- 8 ______ DAY 14 DAY 21 3 ___ 0 -- 7 8 6 8 ______ 6 8 ______ 7 -- -- -- 8 ______ 8 -- 2 -- 0 -- '7 8 6 8 ______ 5 8 ______ 7 -- -- ______ 8 ______ 8 ______ - 1113- Com pany Sanitized. Does not contain T S C A CBI H90--2D47a6y8G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER 646547 646666a 646607 646524s 646600 646648 646594 646546 646661s 646671 646521 646590s 646645 646555s 646605s 646589s 646615 646527s 646647 646675s BORN 4 -- 8 -- 9 6 8 9 -- 3 2 -- 7 -- -- -- 4 -- 13 -- INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 4 -- 8 -- 9 6 8 9 -- 3 2 -- 6 -- -- -- 4 -- 13 -- 4 -- 8 -- 9' 6 8 9 -- 3 2 -- 6 -- -- -- 4 -- 13 -- 4 -- 4 -- 4 6 4 4 -- 3 2 -- 4 -- -- -- 4 -- 6 -- 4 -- 3 -- 4 6 4 4 -- 3 2 -- 4 -- -- -- 4 -- 6 -- DAY 14 DAY 21 2 -- 0 -- 4 6 4 4 -- 2 2 -- 3 -- -- -- 4 -- 6 -- 2 -- 0 -- 4 6 4 4 -- 2 2 -- 3 -- -- -- 4 -- 6 -- - 1114- Company Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER 646547 646666a 646607 646524s 646600 646648 646594 646546 646661s 646671 646521 646590s 646645 646555s 646605s 646589s 646615 646527s 646647 646675s BORN 13 -- 6 -- 8 2 4 6 -- 11 6 -- 7 -- -- -- 8 -- 3 -- INDIVIDUAL PUP SURVIVAL: F 1 GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 D A Y 14 D A Y 21 13 -- 6 -- 8 2 4 6 -- 10 6 -- 6 -- -- -- 8 -- 3 -- 12 -- 6 -- 8 2 4 6 -- 10 6 -- 6 -- -- -- 8 -- 2 -- 4 -- 4 -- 4 2 4 4 -- 5 6 -- 4 -- -- -- 4 -- 2 -- 4 -- 2 -- 4 2 4 4 -- 5 6 -- 4 -- -- -- 4 -- 2 -- 1 -- 0 -- 3 2 2 4 -- 4 6 -- 4 ----- -- -- 4 -- 2 -- 0 -- 0 ___ 3 2 2 4 -- 3 6 -- 4 -- -- -- 4 -- 2 -- - 1115- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER 646547 6466663 646607 6465243 646600 646648 646594 646546 6466613 646671 646521 6465903 646645 6465553 6466053 6465893 646615 6465273 646647 6466753 INDIVIDUAL PUP SURVIVAL: Fa GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 0.24 -- 0.57 -- 0.53 0.75 0.67 0.60 -- 0.21 0.25 -- 0.50 -- -- -- 0.33 -- 0.81 -- 100.0 -- 100.0 -- 100.0 100.0 100.0 100.0 -- 92.9 100.0 -- 85.7 -- -- -- 100.0 -- 100.0 -- 94.1 -- 100.0 t 100.0 100.0 100.0 100.0 -- 100.0 100.0 -- 100.0 -- -- -- 100.0 -- 93.8 -- 25.0 -- 0.0 -- 87.5 100.0 75.0 100.0 -- 62.5 100.0 -- 87.5 . --- -- -- 100.0 -- 100.0 -- - 1116- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ANIMAL NUMBER 646547 6466663 646607 646524a 646600 646648 646594 646546 6466613 646671 646521 6465903 646645 6465553 6466053 6465893 646615 6465273 646647 6466753 INDIVIDUAL PUP SURVIVAL: F x GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY % BORN ALIVE NUMBER OF MALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 -- 100.0 f --- 100.0 100.0 100.0 100.0 -- 100.0 100.0 -- 85.7 -- -- -- 100.0 -- 100.0 -- 100.0 -- 100.0 -- 100.0 100.0 100.0 100.0 -- 100.0 100.0 -- 100.0 -- -- -- 100.0 -- 100.0 -- 50.0 -- 0.0 -- 100.0 100.0 100.0 100.0 -- 66.7 100.0 -- 75.0 -- -- -- 100.0 -- 100.0 -- DuPont-5990 - 1117- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ANIMAL NUMBER 646547 646666^ 646607 6465243 646600 646648 646594 646546 646661 646671 646521 646590 646645 646555 646605 646589 646615 646527 646647 646675 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY % BORN ALIVE NUMBER OF FEMALE PUPS 0-4 DAY VIABILITY LACTATION INDEX oo oo 100.0 -- 100.0 -- 100.0 100.0 100.0 100.0 -- 90.9 100.0 -- 85.7 -- -- -- 100.0 -- 100.0 -- 92.3 -- 100.0 -- 100.0 100.0 100.0 100.0 -- 100.0 100.0 -- 100.0 -- -- -- 100.0 -- 66.7 -- -- -- 75.0 100.0 50.0 100.0 -- 60.0 100.0 -- 100.0 -- -- -- 100.0 -- 100.0 -- DuPont-5990 - 1118- Company Sanitized. Does not contain TSCA CB1 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER 646662 646583s 646623 646619 646539 646628s 646616s 646563s 646641 646572 646512 646566 646570s 646602 646582s 646655 646663 646640e 646574 646532 BORN 11 -- 6 13 12 -- -- -- 13 14 9 10 -- 5 -- 12 13 -- 3 . 13 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 D A Y 14 D A Y 21 11 -- 6 13 12 -- -- -- 11 13 9 9 -- 5 -- 10 10 -- 0 13 11 -- 5 0 8 -- -- -- 11 8 9 9 -- 5 -- 10 9 -- 0 12 ' 8 -- 5 0 8 -- -- -- 8 8 8 8 -- 5 -- 8 8 -- 0 8 6 -- 1 0 4 -- -- -- 7 5 7 8 -- 5 -- 4 8 -- 0 8 0 -- 0 0 0 -- -- -- 0 0 0 4 -- 0 -- 0 6 -- 0 4 0 -- 0 0 0 -- -- -- 0 0 0 3 _____ 0 ___ 0 5 ___ 0 2 - 1119- Company Sanitized. Does not contain TSCA CBI 9H0--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 ANUNMIMBAELR 646662 666644446666566582133399-3 646628^ 646616-a 666664444466666556557146622163 a 6465703 646602 6465823 66 44 66 66 65 35 6466403 66 44 66 55 37 24 BORN 4 -- 354 -- -- -- 5 766 -- 3 -- 76 -- 0 8 INDIVIDUAL PUP SURVIVAL: GENERATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY NUMBER OF MALE PUPS ABOLRIVNE PREDCAUYLL4ING PODSTACYU4LLING DAY 7 4444 -- 35 4 -- 2 0 4 -- 2 40 -- 0 0 1 -- ------ -- ---- -- -- 4 6 65 -- 4 465 -- 4 445 -- 3 245 -- ---- -- 3333 -- 65 -- 64 -- 44 -- 2 4 -- 0 8 -- 08 -- 0 4 -- 0 4 DAY 14 0 -- 0 00 -- -- -- 00 20 -- 0 -- 0 4 -- 01 DAY 21 0 -- 0 0 0 -- -- -- 0 001 -- 0 -- 03 -- 0 1 -1120- Company Sanitized. Does not contain T SC A CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 ANUNMIMBAERL 646662 646583a 666 444 666 665 213 399 646628a 646616a 666664444466666556557146622163 a 664466650720 s 666444666665658352 a 666444666556374240 a BORN 7 -- 3 8 8 -- -- -- 78 43 -- 2 -- 65 -- 3 5 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY NUMBER OF FEMALE PUPS ABOLRIVNE PRECDAUYLL4ING PODSATCYU4LLING DAY 7 DAY 14 77420 ---------- 388 30 4 430 103 ' 000 -- ---- -- -- ------ ---- ------ ---- 7743 7434 4434 2434 2000 -- 2 -- 2 -- 2 -- 2 -- 0 -- 45 -- 4 5 -- 44 -- 24 -- 20 -- -- -- -- ----- 00000 54443 DAY 21 0 -- 000 --- -- -- 0 0 20 -- 0 -- 20 -- 0 1 -1121 - Com pany Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 ANIMAL NUMBER 646662 646583^ 646623 646619 646539 646628a 646616s 646563s 646641 646572 646512 646566 646570s 646602 646582s 646655 646663 646640s 646574 646532 INDIVIDUAL PUP SURVIVAL: F 1 GENERATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 0.36 -- 0.50 0.38 0.33 -- -- -- 0.38 0.50 0.67 0.60 -- 0.60 -- 0.58 0.50 -- 0.00 0.62 100.0 -- 100.0 100.0 100.0 -- -- -- 84.6 92.9 100.0 90.0 -- 100.0 -- 83.3 76.9 -- 0.0 100.0 100.0 -- 83.3 0.0 66.7 -- -- -- 100.0 61.5 100.0 100.0 -- 100.0 -- 100.0 90.0 -- -- 92.3 0.0 -- 0.0 -- 0.0 -- -- -- 0.0 0.0 0.0 37.5 -- 0.0 -- 0.0 62.5 -- -- 25.0 - 1122 - Com pany Sanitized. Does not contain T S C A C 8 I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 646662 6465833 646623 646619 646539 6466283 6466163 6465633 646641 646572 646512 646566 6465703 646602 6465823 646655 646663 6466403 646574 646532 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY % BORN ALIVE NUMBER OF MALE PUPS 0-4 DAY VIABILITY LA C T A T IO N INDEX O o oo oo 100.0 -- 100.0 100.0 100.0 -- -- -- 80.0 85.7 100.0 83.3 -- 100.0 -- 85.7 83.3 -- -- 100.0 100.0 -- 66.7 0.0 100.0 -- -- -- 100.0 66.7 100.0 100.0 -- 100.0 -- 100.0 80.0 -- -- 100.0 -- -- -- -- -- 0.0 0.0 0.0 25.0 -- -- 0.0 75.0 -- -- 25.0 o o DuPont-5990 -1123- Com pany Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ANIMAL NUMBER 646662 646583a 646623 646619 646539 646628a 646616s 646563a 646641 646572 646512 646566 646570a 646602 646582s 646655 646663 646640s 646574 646532 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY % BORN ALIVE 100.0 -- 100.0 100.0 100.0 -- -- -- 87.5 100.0 100.0 100.0 -- 100.0 -- 80.0 83.3 -- 0.0 100.0 NUMBER OF FEMALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 -- 100.0 0.0 50.0 -- -- -- 100.0 57.1 100.0 100.0 -- 100.0 -- 100.0 100.0 -- -- 80.0 0.0 -- 0.0 -- 0.0 -- -- -- 0.0 0.0 0.0 50.0 -- 0.0 -- 0.0 50.0 -- -- 25.0 DuPont-5990 -1124 - Company Sanitized. Does not contain T SC A CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 APPENDIX GG REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP WEIGHTS: F, GENERATION -1125- Com pany Sanitized. Does not contain T SC A CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5990 INDIVIDUAL PUP WEIGHTS: Fi GENERATION EXPLANATORY NOTES Footnotes a No litter delivered. b Litter was weighed before delivery was complete. c One pup was missexed; data were excluded from male and female mean pup weights. d No litter observed; however, implantation sites were observed ^t necropsy. e No live pups. / No live male pups. g No live female pups. - 1126 - Company Sanitized. Does not contain TSC A CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 I n d i v i d u a l P u p W e i g h t s (grains) : Fi Generation Lactation Day 0 Group: II-O Dose: 0 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 8 9 10 11 12 3646653 7.80 7.30 7.60 6.20 7.60 7.60 7.60 7.60 32646575 9 7.30 7.80 6.90 7.10 7.50 7.20 6.00 6.50 7.90 8.10 7.90 7.20 7.50 7.30 7.70 7.30 6.70 3646585a 32646622 * 6.70 6.30 6.70 6.50 6.20 6.60 646550 646526 646503 646644 2 6.70 6.50 6.50 6.70 6.20 6.60 6.40 5.70 3 6.60 6.80 7.10 6.70 6.60 6.20 2 6.60 6.40 6.00 5.90 5.90 6.00 6.60 6.30 6.60 3 8.20 8.40 8.20 7.80 8.20 8.00 7.30 9.20 2 8.10 7.80 8.10 3 7.90 7.30 7.90 8.30 8.20 7.60 8.10 7.00 7.70 2 8.10 7.50 7.50 6.50 7.20 7.20 8.20 3 7.60 2 6.30 7.00 7.30 6.80 6.60 6.70 6.60 4.50 6.90 6.60 2646604 3 6.50 6.70 6.60 6.40 6.50 6.10 6.30 6.90 6.20 6.70 6.40 6.30 4.20 6.60 5.80 2646651k 3 8.50 7.50 7.70 7.20 6.20 8.00 7.10 7.20 7.90 7.70 7.20 6.60 2646552a 2646606 3 6.40 6.40 6.90 6.70 6.60 6.10 6.40 6.30 6.10 6.40 6.40 6.40 6.20 6.20 6.10 2646557 <? 8.20 8.00 7.60 8.50 7.80 8.40 7.70 7.70 7.60 6.90 7.40 7.60 2646591 <? 7.10 6.70 7.40 7.10 7.50 6.90 7.20 7.00 7.30 7.10 6.50 6.70 6.90 6.90 2646544 3 2646646 2646520a 7.60 7.30 7.40 8.10 8.70 6.90 7.90 7.70 8.10 7.10 7.20 7.40 7.70 6.50 6.50 5.80 5.90 5.90 6.40 5.90 5.50 5.80 5.80 5.50 5.70 5.70 5.70 5.30 5.70 5.00 5.00 646569 646654 646668 3 5.40 5.50 6.10 5.70 6.00 5.60 4.70 5.50 4.10 6.20 2 5.50 5.20 5.30 5.70 5.50 5.30 5.30 3 7.50 6.70 7.20 6.90 6.70 6.90 7.30 7.30 2 6.60 6.40 6.50 6.20 6.70 3 7.80 7.40 7.70 7.50 7.20 7.50 7.70 7.40 2 7.10 7.60 7.40 6.70 7.10 7.20 7.10 13 -1127- Company Sanitized. Does not contain T S C A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Individual Pup Weights (grams): Fi Generation Lactation Day 0 Group: IV-0 Dose: 25 mg/kg/day Pup Number 1Animal Pup Number Sex 2 3 4 5 6 7 8 9 10 11 12 646638 646559 699 646598a 69 646561 9 646573a S9 646504e 646587a 646631a S999 7.10 6.90 6.70 6.70 6.80 6.80 6.40 6.30 6.30 6.60 6.40 6.10 6.10 6.70 5.20 6.10 6.30 6.30 8.10 6.90 7.30 7.90 7.80 7.90 6.80 7.10 7.20 7.10 7.30 7.30 7.00 8.60 8.80 8.10 8.30 8.30 8.40 8.10 6.60 6.00 6.60 6.40 6.40 6.30 6.50 5.80 6.30 6.40 6.10 5.90 5.90 6.50 646529 646603 $ 6.50 6.80 6.40 6.80 6.20 6.30 6.20 6.60 6.60 9 5.70 6.00 6.20 5.70 6.40 6.20 6.90 5.70 5.90 6.20 6.00 6.10 5.90 6.00 9 6.00 5.90 6.10 5.90 5.70 6.40 5.70 646554a 9 9646579 5.20 6.60 6.00 6.50 6.30 6.40 6.30 6.50 6.20 6.40 5.80 5.80 5.70 5.60 6.70 646564a 646672 646584a 646543* 646596 SSS99999 8.40 8.40 8.50 8.90 8.90 7.70 8.40 6.20 8.30 7.10 8.40 8.60 7.80 7.70 7.80 7.20 6.00 7.30 7.00 7.70 5.60 5.90 6.60 5.50 6.40 6.30 6.00 6.40 6.80 6.20 5.90 5.90 5.00 4.60 646558a 9 646670a 646553 S9 7.30 7.30 9 6.10 6.20 6.00 6.40 6.20 6.40 6.60 6.30 6.90 13 - 1128- Com pany Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 I n d i v i d u a l P u p W e i g h t s ( g r a m s ) : F]_ G e n e r a t i o n Lactation Day 0 G r o u p : V I -0 Dose: 100 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 8 9 10 11 12 13 646547 6 6.40 6.90 6.30 6.60 2 6.20 6.60 5.90 6.20 6.40 6.70 6.20 6.10 6.40 6.70 6.20 6.40 6.20 646666a <? $ 646607 6 7.60 7.20 7.40 7.70 6.60 7.30 6.50 7.30 2 7.10 6.50 6.90 6.40 7.00 6.^0 646524a 2 646600 6.60 6.40 6.50 6.10 5.90 6.20 6.20 6.80 6.20 S2 6.00 5.70 6.00 6.10 6.70 6.20 6.30 6.50 646648 7.10 7.00 6.00 7.10 6.90 7.20 2 6.90 6.70 646594 6.60 6.70 5.90 6.80 6.00 6.60 6.30 7.10 2 6.10 6.60 6.00 5.90 646546 <s 6.10 6.50 6.00 6.40 6.10 6.20 6.10 5.70 6.20 2 6.00 5.40 5.60 6.20 6.30 6.50 646661a S2 646671 6.50 7.20 6.90 S2 6.80 6.60 6.10 6.00 6.50 6.10 6.70 7.00 6.90 6.30 646521 7.90 8.30 S2 7.90 7.30 7.50 7.80 7.50 5.60 646590a 2 646645 6 6.70 6.50 6.40 7.10 6.40 6.30 2 6.40 5.80 6.80 6.20 6.40 4.40 646555a 6 2 646605a <5 2 646589a 6 S2 646615 8.20 7.70 7.20 7.90 2 7.60 7.10 7.20 7.20 7.20 6.80 7.40 7.90 646527a <? 2 646647 7.30 6.80 7.00 7.30 7.00 6.80 6.90 7.50 6.30 7.00 7.10 6.40 7.20 2 6.90 6.50 6.80 646675a 2 - 1129- Com pany Sanitized. Does not contain T S C A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Individual Pup Weights (grams): Fi Gnration Lactation Day 0 Group: VIII-0 Dose: 500 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 8 9 10 11 12 13 646662 646583a 646623 646619 646539 646628a 646616a 646563a 646641 646572 646512 646566 646570a 646602e 646582a 646655 646663 646640^ 646574e 646532 S 6.60 6.40 6.70 5.80 9 6.10 5.80 5.90 6.00 5.80 6.20 5.30 2 7.20 6.90 6.90 2 5.70 6.60 6.40 6.20 7.00 6.50 7.00 7.20 9 6.80 7.00 6.10 6.50 6.30 5.70 6.00 5.80 <? 6.60 6.30 6.50 6.60 2 5.40 6.20 6.00 6.50 6.10 5.30 5.30 5.90 s 9 S 2 S 2 6.90 6.80 6.70 6.00 2 6.00 6.30 6.60 5.80 6.40 6.20 6.30 5.80 6.10 5.60 6.00 5.40 5.80 2 5.30 4.90 5.50 4.90 5.00 5.30 5.70 6.30 5.70 6.40 6.50 6.00 6.70 2 6.20 5.00 6.40 6.60 6.50 7.10 6.40 6.70 2 6.50 6.20 6.50 6.50 <5 2 7.50 7.40 2 6.80 5.90 6.20 S 2 6.40 6.20 6.80 5.90 6.00 6.50 2 5.80 6.30 6.20 5.80 5.40 5.60 5.90 5.30 5.40 2 5.70 5.20 5.90 5.70 5.30 2 S 2 7.40 6.50 6.50 7.00 6.70 6.60 7.20 6.70 2 6.10 6.30 6.40 6.50 6.20 -1130- Company Sanitized. Does not contain T SC A C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling G r o u p : 1 1 -0 Dose: 0 mg/kg/day Pup Number 1Animal Pup Number Sex 2 3 4 5 6 7 8 9 10 11 12 646653 646575 646585a 646622 646550 646526 646503 646644 646604 646651 646552a 646606 646557 646591 646544 646646 646520a 646569 646654 646668 O O S 11.8 11.4 11.8 12.7 11.8 10.5 13.3 9 10.8 10.8 10.0 12.0 11.3 11.9 10.6 3 14.5 13.1 14.2 9 13.9 12.7 13.0 13.2 14.2 13.3 339 10.0 10.7 10.6 11.3 10.6 10.0 9 10.5 10.7 10.9 10.5 11.2 10.2 10 .2 11 .1 3 7.90 7.50 7.60 7.00 7.60 6.90 9 7.20 7.60 7.30 7.40 6.60 6.70 6 .80 7 .40 7.30 3 15.5 16.5 15.3 15.0 15.1 15.4 14 .8 13 .6 9 14.9 15.1 14.7 11.7 13.3 14.3 13.1 14.2 14.1 13 .4 14 .3 9 14.0 12.7 11.5 13.4 12.4 3 12.6 9 11.5 12.4 11.4 11.4 11.8 10.9 10.8 7.90 10.4 11.1 13.1 10.9 3 9.60 11.0 9.40 10.2 10.4 11.3 11.2 10.6 9 10.7 9.80 9.00 10.4 9.50 10.2 6.50 3 11.3 10.9 11.3 13.2 11.9 11.7 39 11.1 11.6 11.5 11.7 10.4 11.7 11.7 10.6 12.2 12.1 9 11.8 11.7 11.1 11.3 9 10.7 13.2 11.1 11.0 10.8 10.6 10.5 11.1 10.2 10.7 10.3 3 12.4 13.0 12.8 13.0 13.0 11.5 9 12.3 11.7 12.6 11.7 11.6 12.3 12.4 12.1 13.2 11.8 11.5 11.8 11.0 11.8 11.7 11.2 9 10.9 12.4 11.0 11.6 3 14.6 13.8 13.6 15.5 14.9 9 13.5 13.0 12.4 13.8 13.8 10 .8 12 .9 14..3 3 9.80 8.80 9.60 8.80 11.0 7. 10 9. 90 10..9 10.0 11.1 9 8.60 10.4 10.1 9.00 8.60 9. 90 8. 90 10..7 339 9.30 9.00 10.5 8.30 9.70 7. 7. 70 6. 90 8.80 10.9 9.00 9.10 9 9.20 9.20 8.20 8.50 7.80 9. 30 8. 10 3 13.8 13.0 11.8 12.1 13.2 12 .7 12 .6 13 .5 9 11.8 12.1 12.0 12.0 11.6 3 11.6 12.6 11.8 12.9 11.4 13 .0 12 .4 13 .4 9 11.8 12.2 12.0 10.3 10.5 11 .4 11 .2 13 - 1131 - Com pany Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Group : IV-0 Dose: 25 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 8 9 10 11 12 646638 $ 11.1 10.6 10.7 9.20 11.3 10.4 12.0 11.7 11.4 10.8 S$ 10.2 10.8 9.80 11.4 8.60 9.60 9.80 9.60 646559 13.4 13.0 12.4 11.2 12.2 13.7 2 12.2 13.8 11.2 12.0 12.3 646598a <? 2 646561 6 16.2 17.1 16.1 16.4 16.5 16.5 2 15.2 646573a 2 646504 11.3 11.0 10.9 10.7 10.8 10.0 11.2 11.1 10.8 11.5 10.9 2 10.5 10.5 10.7 646587a 646631a 2 2 646529 12.1 13.5 12.6 12.9 12.4 13.7 13.2 12.9 12.3 646603 2 12.4 11.7 12.3 6 10.0 10.6 11.8 10.1 10.6 9.90 10.7 10.6 11.5 10.5 10.4 2 9.90 9.60 9.50 11.1 10.4 7.90 10.3 646554a <5 S2 646579 9.90 9.60 10.2 10.6 10.2 8.20 10.5 10.6 10.0 2 9.40 9.40 9.60 10.2 9.40 10.5 646564a s2 646672 14.1 14.9 15.5 15.5 15.4 2 15.1 15.5 13.2 12.9 14.1 14.0 15.4 15.5 646584a 2 646543 14.0 15.1 14.0 2 15.0 14.2 14.0 13.8 12.0 646596 10.0 11.3 9.50 11.3 12.1 9.50 11.3 11.7 11.6 2 11.0 5.60 10.8 10.8 10.3 646558a s 646670a <2? 2 646553 13.2 13.3 2 11.8 12.2 10.9 11.8 12.2 11.9 11.2 11.7 12.4 13 -1132- Com pany Sanitized. Does not contain T SC A CB I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 I n d i v i d u a l P u p W e i g h t s (grains) : F]_ G n r a t i o n Lactation Day 4 Preculling G r o u p : V I -0 Dose: 100 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 8 ' 10 11 12 13 646547 <5 10.7 7.10 8.60 10.0 8.20 9.40 8.00 9.50 11.0 9.50 9. 60 8. 00 646666a <? 646607 9 8.20 7.30 8.90 7.1 10.0 9.00 8. 60 8 .70 9 10.9 10.2 8.60 8.60 9.10 7.90 646524a 646600 646648 646594 646546 9 6 10.3 10.1 9.90 10.9 11.6 7.60 11 .4 12 .4 9 9.30 10.8 11.6 10.0 8.10 11.3 10 .6 11 .4 S 14.0 14.9 12.5 13.1 13.0 13.4 9 12.4 13.0 6 11.0 13.0 12.9 12.8 12.3 12.7 11 .6 10 .4 9 10.8 11.2 11.5 9.60 10.8 10.9 11.2 11.0 10.6 8.90 10 .3 9. 00 9 10.3 10.3 10.2 11.4 11.1 8.70 646661a 646671 646521 9 8.40 9.90 10.2 9 8.40 9.20 9.00 9.60 8.00 8.70 8. 80 8. 80 12.4 12.9 9 12.1 11.3 12.7 7.80 11.2 12.2 646590a 646645 9 s 12.6 12.2 13.3 13.0 10.3 12.4 9 11.2 11.4 12.1 11.9 7.50 11.6 646555a S 9 646605a S 9 646589a 646615 9 S 12.9 12.9 13.1 11.4 9 12.0 12.4 12.4 12.8 13.0 11.9 12 .5 12 .0 646527a S 646647 9 S 10.9 8.60 9.90 10.0 9.00 10.3 9. 00 10 .8 9 9.30 8.30 646675a 9 -1133- Com pany Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Preculling Group: VIII-0 Dose: 500 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 8 9 10 11 12 13 646662 S 7.40 8.50 7.20 8.30 9 7.60 6.80 6.80 6.90 6.40 7.80 7.50 6465833 S 646623 9 6 8.30 7.40 9 7.50 7.10 6.00 646619e S 646539 9 6.40 6.30 6.70 6.70 9 6.90 6.30 6.30 5.80 646628e 6 9 6466163 9 6465633 646641 646572 646512 646566 9 S 8 .40 7..00 9. 10 7. 80 9 7 .90 6..40 7 .80 8. 80 8..30 8..40 8.00 S 6 .00 5..20 6 .00 6. 50 9 5. 60 6..10 4. 30 5. 40 c 9. 40 8..60 9. 60 10'.5 8..40 8..80 9 9. 30 9..20 7 .50 12 .1 9..50 10 .5 7 .60 8..80 9 11 .2 9..60 11 .7 9 .50 6465703 646602 9 10 .1 11 .4 11.9 9 9. 10 9. 60 6465823 646655 646663 9 6 8.40 8.70 9.10 8.00 9.00 8.90 9 8.80 8.30 9.50 9.70 8.30 7.70 6.50 7.80 9 9.60 8.30 8.80 6.30 6.10 646640 9 646574e 646532 9 s 10.1 9.70 10.6 8.60 10.8 10.4 8.90 8.50 9 9.90 9.40 10.2 7.00 - 1134Company Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Postculling Group: II-O Dose: 0 mg/kg/day Animal ,,Pup --Pup--N-u-m-b-e-r- Number Sex 1 2 3 4 5 6 7 646653 646575 646585-3 646622 646550 646526 646503 646644 646604 646651 646552a 646606 646557 646591 646544 646646 6465203 646569 646654 646668 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 11.8 11.4 11.8 11.8 11.3 12.0 11.9 10.6 14.5 13.1 14.2 13.9 12.7 13.0 13.2 14.2 10.6 11.3 10.6 10.0 10.9 11.2 10.2 11.1 7.50 7.60 7.60 6.90 7.60 7.30 6.70 7.40 15.5 15.0 15.1 15.4 14.8 14.9 15.1 14.7 13.1 14.1 13.4 14.3 12.7 11.5 13.4 12.4 12.6 12.4 11.4 11.4 11.8 10.9 10.4 11.1 9.40 10.2 11.2 10.6 10.7 10.4 9.50 6.50 10.9 11.3 11.9 11.7 11.6 11.7 12.2 12.1 11.8 11.7 11.1 11.3 13.2 11.1 10.5 11.1 13.0 12.8 13.0 11.5 11.7 12.6 11.7 11.6 11.8 11.5 11.8 11.2 10.9 12.4 11.0 11.6 14.6 13.6 15.5 14.9 13.0 13.8 12.9 14.3 11.0 7.10 10.9 10.0 10.1 9.00 9.90 8.90 9.00 10.5 8.80 9.00 9.20 8.50 9.30 8.10 11.8 12.1 13.2 12.7 12.1 12.0 12.0 11.6 11.6 11.8 12.9 12.4 12.2 12.0 10.3 10.5 DuPont-5990 -1135- Company Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains) : Fi Gnration Lactation Day 4 Postculling Group: IV-0 Dose: 25 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 646638 11.3 10.4 12.0 11.4 2 10.8 9.80 11.4 9.60 646559 13.0 12.4 11.2 13.7 2 12.2 13.8 12.0 12.3 646598a $ 646561 2 6 16.2 17.1 16.1 16.4 16.5 2 15.2 646573a 6 646504 2 6 11.3 11.0 10.9 10.7 11.1 2 10.5 10.5 10.7 646587a 2 646631a S 646529 646603 2 12.9 12.4 13.7 13.2 12.9 2 12.4 11.7 12.3 S 10.6 11.8 10.6 9.90 2 9.50 11.1 10.4 7.90 646554a 646579 2 S 10.6 10.2 8.20 10.5 2 9.40 9.40 9.60 9.40 646564a S 646672 2 14.1 15.5 15.5 15.4 2 15.1 15.5 14.0 15.4 646584a 646543 646596 2 14.0 15.1 14.0 2 15.0 14.2 14.0 13.8 12.0 11.3 11.3 9.50 11.6 2 11.0 10.8 10.8 10.3 646558a 2 646670a 646553 2 s 13.2 13.3 2 11.8 10.9 12.2 11.9 11.2 DuPont-5990 -1136- Com pany Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group : VI:-0 Dose: 100 mg/kg/day Animal Pup Pup Number Number Sex l 2 3 4 5 6 7 646547 646666s 646607 3 10.7 7.10 8.60 10.0 9 9.40 9.60 8.00 9.50 3 9 3 8.90 7.10 10.0 8.60 $ ,10.9 10.2 8.60 9.10 646524s 646600 646648 646594 646546 3 9 3 9 3 9 3 9 3 9 10.1 9.90 11.6 11.4 11.6 10.0 8.10 10.6 14.0 14.9 12.5 13.1 13.0 13.4 12.4 13.0 13.0 12.3 12.7 10.4 10.8 11.2 11.5 9.60 10.8 10.9 11.2 10.6 10.3 10.2 11.4 11.1 646661s 3 646671 646521 9 3 8.40 9.90 10.2 9 9.60 8.70 8.80 8.80 10.0 3 12.4 12.9 9 12.1 11.3 12.7 7.80 11.2 12.2 646590s 646645 646555s 646605s 646589s 646615 3 9 3 9 3 9 3 9 3 9 3 9 12.6 12.2 13.3 10.3 11.4 11.9 7.50 11.6 12.9 12.9 13.1 11.4 12.4 12.8 13.0 11.9 646527s 646647 3 9 3 9 9.90 10.8 10.6 10.0 9.90 9.10 9.30 8.30 646675s 3 9 DuPont-5990 - 1137- Com pany Sanitized. Does not contain T S C A C B I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains) : Fi Gnration Lactation Day 4 Postculling Group: VIII-0 Dose: 500 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 646662 646583a 646623 646619e 646539 646628a 646616a 646563a 646641 646572 646512 646566 646570a 646602 646582a 646655 646663 646640*3 646574e 646532 6 7.40 8.50 7.20 8.30 9 7.60 6.80 6.80 7.80 <? 9 a 8.30 7.40 $ 7.50 7.10 6.00 <? 9 S 6.40 6.30 6.70 6.70 9 6.90 6.30 6.30 5.80 a 9 a 9 a 9 a 8.40 7.00 9.10 7.80 9 7.90 6.40 8.30 8.00 a 6.00 5.20 6.00 6.50 9 5.60 6.10 4.30 5.40 a 8.60 9.60 10.5 8.40 8.80 9 9.30 9.20 7.50 a 12.1 9.50 10.5 8.80 9 11.2 9.60 11.7 9.50 a 9 a 10.1 11.4 11.9 9 9.10 9.60 a 9 a 8.40 9.10 9.00 8.90 9 8.80 8.30 9.50 9.70 a 8.30 7.70 6.50 7.80 9 8.30 8.80 6.30 6.10 a 9 a 9 a 9.70 10.6 10.8 8.90 9 9.90 9.40 10.2 7.00 DuPont-5990 -1138- Com pany Sanitized. Does not contain TSC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 7 Group : II-O Dose: 0 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 646653 646575 6 19.0 20.0 18.7 19.5 $ 18.1 17.0 19.0 19.6 d 20.3 18.4 20.2 $ 19.2 19.9 19.9 18.1 18.6 646585a d 646622 646550 646526 646503 646644 646604 646651 2 d 19.6 17.8 18.9 16.8 2 17.5 16.8 17.5 17.6 d 12.3 11.9 11.9 11.1 2 10.9 11.7 10.8 11.1 d 23.2 23.8 22.9 23.5 23.1 2 22.7 22.7 22.4 d 22.2 23.3 21.2 22.2 2 21.4 19.8 18.9 21.3 d 19.3 2 17.6 19.1 17.7 17.8 18.1 18.1 17.1 d 16.9 18.6 18.1 19.7 2 18.7 18.7 17.1 11.8 d 19.0 17.8 18.4 17.7 2 19.1 18.1 18.1 17.1 6465523 d 646606 646557 646591 646544 646646 2 d 17.8 18.5 18.9 18.1 2 18.1 17.0 16.9 15.8 d 18.8 20.1 20.1 19.9 2 18.6 18.6 18.4 18.5 d 20.1 19.8 18.6 19.3 2 18.8 18.5 20.0 19.4 d 23.1 22.3 23.8 20.5 2 20.9 20.3 22.8 19.8 d 12.6 17.4 18.1 15.3 2 15.3 16.6 15.4 14.3 6465203 d 646569 646654 646668 2 d 15.4 17.1 14.7 13.7 2 15.4 14.0 13.8 13.6 d 20.2 20.7 21.2 19.8 2 19.4 19.3 19.0 20.2 d 18.1 19.4 21.0 20.3 2 19.9 20.1 16.7 17.7 DuPont-5990 - 1139- Company Sanitized. Does not contain T SC A CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 7 Group : IV-0 Dose: 25 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 646638 646559 <? 19.7 19.8 17.5 19.3 9 18.5 18.2 15.1 16.6 6 19.3 20.6 20.0 17.3 9 19.1 18.4 18.6 19.7 646598a <5 646561 9 22.8 22.8 22.4 23.3 23.7 9 21.9 646573a 646504 9 16.7 17.0 18.3 17.1 17.6 9 16.3 16.9 16.4 646587a s 9 646631a S 646529 646603 9 S 18.9 19.3 19.1 20.2 20.0 9 18.4 17.7 19.5 6 16.8 18.1 15.7 16.7 9 15.1 15.2 17.7 13.4 646554a 646579 9 17.3 17.5 17.7 13.9 9 15.8 16.4 15.4 17.1 646564a 646672 9 22.6 23.6 24.1 23.8 9 22.0 23.3 22.8 23.5 646584a S 646543 646596 9 <? 19.8 19.5 20.8 9 19.3 16.8 21.0 20.2 19.8 6 15.0 17.9 17.7 17.6 9 15.0 16.7 17.2 17.2 646558a 9 646670a 646553 9 <? 20.8 21.1 9 19.1 18.6 18.1 18.7 18.4 7 DuPont-5990 - 1140- Com pany Sanitized. Does not contain T S C A C 8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 7 Group: VI-0 Dose: 100 mg/kg/day 1Animal Pup Number Sex Pup Number 23456 646547 3 646666a 399 646607 39 646524a 646600 3399 646648 3 646594 399 646546 39 646661a 646671 339 646521 39 646590a 646645 646555a 646605a 646589a 33333999999 646615 39 646527a 39 646647 646675a 3399 8.70 14.3 16.9 9.40 13.5 12.3 10.6 12.0 8.30 9.50 8.10 10.7 7.70 15.0 15.0 18.1 18.4 11.2 18.2 16.9 16.7 17.4 18.9 19.0 19.3 19.7 20.9 18.7 17.8 19.5 19.4 19.5 17.2 14.0 14.8 17.0 17.6 17.5 16.5 17.4 16.6 17.3 16.7 18.0 15.9 12.7 17.6 13.6 15.7 16.8 15.3 12.3 13.0 18.5 18.8 18.4 18.3 18.6 17.0 12.9 17.6 19.8 18.1 17.6 12.4 17.2 18.2 17.3 10.0 17.3 20.5 20.6 20.4 20.0 18.6 19.4 19.8 15.3 16.9 15.7 15.2 16.3 17.3 14.0 15.0 7 DuPont-5990 - 1141 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains) : Lactation Day 7 Gnration Group: VIII-0 Dose: 500 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 646662 i il .2 10 .4 7 .20 8. 10 9 646583a $ 9 646623^ S 9 9 .80 8. 60 7. 50 f 646619e 9 646539 <? 6. 60 9 5. 90 6. 60 5. 70 646628a 9 646616a S 9 646563a S 9 646641 7 .70 10 .1 9. 10 9 8 .60 7 .10 8 .10 8 .60 646572 6. 00 6. 10 9 4. 80 5. 40 5 .80 646512 6 13 .6 12 .1 10 .4 14 .7 11 9 12 .9 12 .4 646566 9. 20 13 .6 11 .3 10 .5 9 11 .4 12 .5 10 .2 12 .6 646570a 9 646602 646582a 646655 99 646663 s99 646640d 646574e 99 646532 9 16 .1 11 .9 14 .0 13 .1 12 .3 9. 90 7. 90 11 .2 9. 50 11 .4 9. 50 11 .2 12 .2 15 .0 7. 30 13 .4 8. 00 14 .3 14 .3 12 .1 16 .1 14 .7 16 .5 15 .8 8. 70 DuPont-5990 - 1142- Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 14 Group : II-O Dose: 0 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 646653 <? 38.7 39.2 39.9 39.7 $ 36.6 38.8 39.4 40.0 646575 6 37.4 37.7 39.3 S2 36.5 38.8 35.4 35.6 37.6 646585a S2 646622 37.3 38.2 40.0 37.6 646550 646526 646503 2 36.9 35.7 36.5 37.4 6 32.0 32.1 32.7 32.9 2 30.9 31.4 30.6 29.1 6 43.5 43.3 43.1 42.8 43.8 2 41.6 41.7 42.3 42.3 43.9 40.0 44.3 646644 646604 2 40.3 39.4 37.6 41.2 <? 37.4 <52 37.2 39.8 37.6 39.4 37.8 37.3 36.9 38.9 38.9 38.1 37.2 2 38.4 29.5 38.0 35.7 646651 35.9 38.7 36.4 38.0 2 35.6 38.5 37.3 39.1 646552a S S2 646606 38.3 39.5 37.4 37.4 2 36.8 37.8 35.9 35.2 646557 6 35.9 38.5 38.9 37.4 2 36.9 36.6 36.6 36.8 646591 42.0 40.5 43.1 41.0 646544 646646 2 39.1 42.9 39.8 41.4 <? 44.0 46.0 42.8 40.7 2 43.1 40.3 40.9 38.0 36.9 34.7 38.6 29.0 2 33.6 33.3 33.4 35.5 646520-a 2 646569 30.3 36.3 33.5 34.2 S2 33.0 33.7 30.0 29.0 646654 40.5 41.4 42.4 41.5 S2 38.5 38.7 41.7 39.6 646668 40.5 42.4 38.9 41.1 2 41.6 41.6 37.1 38.2 DuPont-5990 - 1143 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams) : F]_ Generation Lactation Day 14 Group: IV-0 Dose: 25 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 646638 646559 S9 646598a S99 646561 9 646573a 646504 s699 646587a S9 646631a 646529 646603 S99 9 646554a 646579 99 646564a 646672 9 9 38.7 38.8 36.4 37.9 32.1 33.5 37.4 38.8 38.9 36.2 38.0 36.4 36.5 36.1 36.3 37.2 42.6 43.4 42.1 41.5 42.3 39.8 34.5 38.0 36.4 35.5 35.1 34.8 34.3 33.8 39.8 37.3 39.9 40.5 40.5 37.6 38.3 35.4 36.0 37.8 36.3 35.2 31.2 34.0 34.3 37.8 35.4 31.9 36.4 35.1 32.9 35.4 33.6 34.4 45.2 46.1 45.9 47.0 45.3 44.8 46.2 42.4 646584a <? 9646543 s9646596 S9646558a 37.7 38.6 39.0 39.1 38.6 37.0 37.6 33.4 37.4 36.6 35.9 33.6 32.2 35.3 34.4 34.8 646670a 99 646553 39.0 41.8 9 35.4 38.7 37.0 36.0 36.1 6 7 DuPont-5990 -1144- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 14 Group: VI-0 Dose: 100 mg/kg/day Pup Number 1Animal Pup Number Sex 23456 646547 3 646666a 399 646607e 646524a 646600 646648 646594 646546 33333399999 9 646661a 39 646671 646521 646590a 646645 646555a 646605a 646589a 33333339999999 646615 646527a 3399 646647 39 646675a 39 41.5 22.1 24.6 37.4 30.0 38.8 35.1 38.7 37.2 37.7 40.0 38.7 41.9 37.5 38.8 37.2 36.5 38.8 42.7 42.0 42.6 40.4 39.2 40.1 35.3 34.5 34.2 35.4 35.8 32.7 35.1 35.2 37.8 42.1 36.9 38.5 40.1 12.2 35.8 37.0 36.6 34.4 27.4 36.0 35.9 36.4 36.2 37.9 38.6 35.9 35.6 35.8 16.2 39.1 39.1 38.9 35.2 36.7 35.7 38.5 38.8 35.2 38.2 32.5 35.4 36.7 34.5 35.0 32.9 7 DuPont-5990 - 1145 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 14 Group: VIII-0 Dose: 500 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 646662e <2J 646583a 69 646623e <$ 646619e 9 9 646539e <9? 646628a 9 2646616a d 646563a <9? 646641e <9? 646572e <? 9 646512e <9? 646566 2 2 . 9 13.4 9 18.1 17.4 646570a 9 646602e $9 646582a 9 64 66 55e 9 646663 9 27.0 21.9 26.9 16.2 29.5 26.6 2646640^ <? 646574e 69 646532 29.1 9 25.3 19.4 11.7 DuPont-5990 - 1146- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains) : Fi Gnration Lactation Day 21 Group : II-O Dose: 0 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 646653 646575 6465853 646622 646550 646526 646503 646644 646604 646651 6465523 646606 646557 646591 646544 646646 6465203 646569 646654 646668 S 2 2 6 2 6 2 6 2 6 S2 2 S2 2 2 2 S2 2 S2 S2 2 2 2 2 S 2 70.2 69.0 66.2 69.2 66.3 68.1 62.0 68.7 67.5 66.6 59.2 64.9 62.7 61.9 66.6 61.5 59.0 62.0 57.8 64.5 57.8 59.4 57.3 58.8 59.9 60.7 57.9 59.4 52.1 57.1 58.2 52.6 76.5 72.0 70.5 71.5 74.1 69.9 68.4 70.3 69.6 65.7 76.1 74.8 70.5 64.7 70.2 62.4 52.5 51.6 51.3 52.4 49.6 49.0 50.8 49.4 62.5 61.2 57.9 61.7 45.7 57.4 59.1 58.7 67.1 66.2 63.0 64.4 67.4 66.4 64.7 67.3 59.8 62.9 61.8 56.3 58.1 55.4 55.1 56.7 69.9 67.0 69.1 68.7 65.7 63.7 63.9 64.5 67.7 66.1 68.7 71.7 69.9 64.2 63.4 63.7 75.2 69.6 71.8 66.5 70.4 63.0 59.6 65.1 46.0 63.8 53.7 59.7 48.4 54.4 55.3 54.2 53.4 57.5 55.9 55.0 54.4 47.3 53.4 48.3 63.8 66.7 67.0 69.6 65.5 60.8 63.2 63.7 68.5 72.8 65.3 68.1 69.1 64.2 65.5 71.2 DuPont-5990 - 1147- Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grains): Fi Gnration Lactation Day 21 Group : IV--0 Dose: 25 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 646638 646559 339 646598a 399 646561 3 646573a 399 646504 39 646587a 9 646631a 9 646529 3 646603 99 646554a 39 646579 39 646564a 39 646672 9 646584a 646543 339 646596 39 646558a 646670a 33999 646553 39 61.4 59.0 59.6 60.9 52.1 60.3 54.8 59.3 59.8 65.7 60.6 55.1 59.6 61.3 58.6 60.7 74.4 73.1 70.2 72.5 73.0 66.1 58.2 59.9 63.8 61.3 59.6 57.7 59.2 56.5 62.4 60.2 59.2 62.4 59.5 54.2 54.8 57.9 58.5 58.5 62.0 63.1 63.4 56.0 51.9 55.9 57.1 52.6 54.3 58.7 52.7 52.5 53.2 53.6 75.1 69.8 64.6 72.0 69.6 65.4 69.7 69.8 64.2 66.3 62.5 60.1 53.4 63.7 59.6 62.0 63.3 53.7 61.0 60.6 57.2 57.8 57.4 35.9 58.0 54.5 48.2 50.6 52.1 48.5 48.3 7 DuPont-5990 -1148- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Pup Weights (grams) : F]_ Generation Lactation Day 21 Group : VI: - o Dose: 100 mg/kg/day Animal Pup Pup Number Number Sex l 2 3 4 5 6 6465479' 32 29.0 52.7 646666a 62 646607e 646524a 622 62646600 61.1 64.7 49.5 57.4 61.2 58.8 63.6 646648 646594 S 63.5 68.1 63.8 60.6 59.5 58.8 2 59.7 55.0 3 71.6 68.9 68.3 71.1 2 67.3 64.0 S2646546 55.0 45.8 57.7 54.1 54.1 54.7 56.5 55.9 6466613 32 32646671 67.1 62.8 63.0 59.5 64.2 32646521 63.2 57.0 57.9 61.0 58.2 56.0 45.6 58.2 6465903 S2 646645 S 63.5 65.8 64.1 2 61.7 61.1 24.1 62.0 6465553 6466053 322 6465893 32 32646615 60.6 68.9 66.3 69.1 64.6 66.0 59.0 68.4 6465273 646647 332 2 59.5 56.5 54.7 56.1 61.7 63.9 54.9 56.9 6466753 32 7 DuPont-5990 -1149- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group : VIII-0 Dose: 500 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 646662e 9 646583a S9 64|?623e 9 646619e 9 646539e 9 646628a 69 646616a S9 646563a c9? 646641e 9 646572e 9 646512e S9 646566 S9 34.1 32.5 28.2 646570a S9 646602e S9 646582a S9 646655e 9 646663 S9 646640d 9 646574e 9 646532 S 9 38.3 38.0 40.3 42.1 42.6 27.9 18.3 DuPont-5990 - 1150- Company Sanitized. Does not contain TSCA C8I H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 APPENDIX HH REPRODUCTIVE TOXICOLOGY INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F, GENERATION -1151 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5990 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F, GENERATION EXPLANATORY NOTES Footnotes a All pups were found dead on Lactation Day 0. - 1152 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F3. GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 646653 NO ABNORMALITIES DETECTED 646575 NO ABNORMALITIES DETECTED 646622 NO ABNORMALITIES DETECTED 64655b NO ABNORMALITIES DETECTED 646526 NO ABNORMALITIES DETECTED 646503 NO ABNORMALITIES DETECTED 646644 NO ABNORMALITIES DETECTED 646604 NO ABNORMALITIES DETECTED 646651 DAY 0 DAY 4 PRE 1 OF 16 1 OF 16 1 OF 16 1 OF 16 1 OF 16 1 OF 16 PARTIALLY CANNIBALIZED RIGHT REAR LEG(S ) PARTIALLY CANNIBALIZED RIGHT REAR PAW(S) PARTIALLY CANNIBALIZED TAIL PARTIALLY CANNIBALIZED RIGHT REAR LEG(S ) PARTIALLY CANNIBALIZED RIGHT REAR PAW(S ) PARTIALLY CANNIBALIZED TAIL LITTER SUMMARY: 1 1 1 PARTIALLY CANNIBALIZED RIGHT REAR LEG(S ) PARTIALLY CANNIBALIZED RIGHT REAR PAW(S ) PARTIALLY CANNIBALIZED TAIL 646606 NO ABNORMALITIES DETECTED 646557 NO ABNORMALITIES DETECTED 646591 NO ABNORMALITIES DETECTED 646544 NO ABNORMALITIES DETECTED 646646 NO ABNORMALITIES DETECTED 646569 NO ABNORMALITIES DETECTED 646654 NO ABNORMALITIES DETECTED 646668 NO ABNORMALITIES DETECTED -1153- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fx GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 646638 NO ABNORMALITIES DETECTED 646559 NO ABNORMALITIES DETECTED 646561 NO ABNORMALITIES DETECTED 646504 NO ABNORMALITIES DETECTED 646529 NO ABNORMALITIES DETECTED 646603 NO ABNORMALITIES DETECTED 646579 NO ABNORMALITIES DETECTED 646672 NO ABNORMALITIES DETECTED 646543 NO ABNORMALITIES DETECTED 646596 NO ABNORMALITIES DETECTED 646553 NO ABNORMALITIES DETECTED -1154- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fj. GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 646547 NO ABNORMALITIES DETECTED 646607 NO ABNORMALITIES DETECTED 646600 NO ABNORMALITIES DETECTED 646648 NO ABNORMALITIES DETECTED 646594 NO ABNORMALITIES DETECTED 646546 NO ABNORMALITIES DETECTED 646671 NO ABNORMALITIES DETECTED 646521 NO ABNORMALITIES DETECTED 646645 NO ABNORMALITIES DETECTED 646615 NO ABNORMALITIES DETECTED 646647 NO ABNORMALITIES DETECTED - 1155- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fj. GENERATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 646662 NO ABNORMALITIES DETECTED 646623 NO ABNORMALITIES DETECTED 646619 NO ABNORMALITIES DETECTED 646539 NO ABNORMALITIES DETECTED 646641 NO ABNORMALITIES DETECTED 646572 NO ABNORMALITIES DETECTED 646512 NO ABNORMALITIES DETECTED 646566 NO ABNORMALITIES DETECTED 646602 NO ABNORMALITIES DETECTED 646655 NO ABNORMALITIES DETECTED 646663 NO ABNORMALITIES DETECTED 646574a DAY 21 1 OF 2 1 OF 2 1 OF 2 1 OF 2 STAINED PERINEUM YELLOW WET PERINEUM LETHARGY WEAK LITTER SUMMARY: 1 1 1 1 STAINED PERINEUM WET PERINEUM LETHARGY WEAK DAY 21 PUP DATA: PUP: a STAINED PERINEUM YELLOW WET PERINEUM LETHARGY WEAK - 1156- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 APPENDIX H REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS: F, GENERATION - 1157 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS: F, GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. Footnotes a Sacrificed by design Test Day 15. b Sacrificed by design on Test Day 13. c Found dead on Test Day 3. d Found dead on Test Day 5. e Found dead on Test Day 2. Abbreviations -- = No data. DuPont-5990 - 1158- Company Sanitized. Does not contain TSCA CBI 9H0--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHTS (grams) OF Fx MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 649992 649993 649994 649995 649996 649997 649998 649999 650000 650001 650002 650003 650004 650005 650006 650007 650008 1 8 15 22 29 36 69.2 59.2 64.5 59.4 74.1 74.8 52.5 61.7 64.4 56.3 68.7 71.7 66.5 59.7 55.0 69.6 68.1 112.2 108.5 107.7 99.3 120.8 123.2 97.1 110.6 115.0 98.3 112.8 118.7 110.4 102.6 87.0 116.3 115.6 173.6 174.3 173.6 159.7 186.9 190.2 154.1 175.4 180.2 162.1 179.1 188.5 176.1 164.6 134.0 179.0 179.9 241.3 252.0 239.5 218.1 254.6 254.0 225.7 246.6 252.1 228.0 244.1 267.8 232.0 239.9 190.5 247.2 244.6 303.5 323.3 304.2 282.9 326.0 318.5 290.7 310.5 319.5 287.0 314.6 336.0 278.7 303.3 247.4 310.2 306.3 354.7 388.4 365.3 352.3 396.0 380.9 346.7 370.8 397.1 332.7 382.6 395.6 329.9 369.1 304.8 366.1 367.7 - 1159- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHTS (grams) OF F 1 MALE RATS GROUP: III-l DOSE: 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650009 650010 650011 650012 650013 650014 650015 650016 650017 650018 650019 1 8 15 22 29 36 60.9 55.1 71.1 59.6 59.5 63.1 58.7 72.0 62.5 60.6 54.5 103.0 105.7 116.4 105.5 101.3 101.6 105.4 120.6 102.5 103.6 107.2 164.6 168.2 187.6 176.6 164.6 160.4 158.3 190.8 160.7 167.2 167.4 230.3 234.3 259.2 252.8 230.9 222.0 215.4 268.0 226.4 230.6 233.8 288.7 294.5 328.9 326.8 301.1 283.1 272.2 338.3 293.8 286.1 295.5 338.8 352.6 393.6 400.6 360.6 348.8 327.6 410.1 344.4 346.8 354.7 -1160- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHTS (grams) OF FT MALE RATS GROUP: V-l DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650020 650022 650023 650024 650025 650026 650027 650028 650029 650030 1 8 15 22 29 36 52.7 57.4 58.8 71.1 54.1 62.8 57.0 64.1 69.1 63.9 87.5 92.7 103.3 114.1 101.9 105.6 99.5 110.6 116.3 103.6 136.6 160.3 167.1 183.0 160.8 171.2 132.2 173.7 182.2 163.1 196.0 234.8 228.6 254.3 215.3 240.2 198.7 243.2 250.3 231.9 250.9 299.6 286.1 330.1 272.5 302.5 253.3 306.7 318.0 299.2 309.0 356.5 346.2 411.0 332.5 368.8 307.7 365.7 367.0 359.7 - 1161 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (grams) OF Fx MALE RATS GROUP: VII-1 DOSE: 500 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650032a 650035* 650036e 1 8 15 34.1 40.3 27.9 68.0 72.9 --- 116.5 --- 22 ----- 29 ----- DuPont-5990 36 - 1162- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T S (grams) O F Fj. F E M A L E R A T S GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650043 650044 650045 650046 650047 650048 650049 650050 650051 650052 650053 650054 650055 650056 650057 650058 650059 ' 1 8 15 22 29 36 68.7 61.5 58.8 52.6 70.3 62.4 49.4 58.7 67.3 56.7 64.5 63.7 65.1 54.2 48.3 63.7 71.2 114.5 111.8 87.4 87.3 123.4 98.8 92.9 104.2 112.9 90.7 98.5 101.9 107.1 93.3 78.4 106.3 122.3 161.2 159.8 124.2 128.4 172.2 139.5 134.3 147.2 153.0 131.8 145.5 138.8 150.0 144.3 109.7 141.5 174.0 186.9 190.5 152.4 159.8 199.6 159.8 167.5 181.9 176.6 168.4 176.1 174.4 179.9 179.2 143.4 177.1 218.1 213.4 201.1 178.4 169.9 236.9 182.4 187.1 216.3 211.1 190.0 191.6 202.9 201.1 201.4 169.9 195.9 244.9 225.7 227.2 205.0 197.4 260.7 194.9 208.7 238.3 231.7 217.3 214.1 224.5 221.0 228.2 185.3 210.4 268.4 - 1163- Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T S (grams) O F Fi F E M A L E R A T S GROUP : IV-1 DOSE : 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650060 650061 650062 650063 650064 650065 650066 650067 650068 650069 650070 1 8 15 22 29 36 59.3 60.7 66.1 56.5 57.9 55.9 53.6 69.8 62.0 35.9 48.9 95.3 77.5 117.3 95.7 101.0 96.5 80.6 105.0 98.8 86.2 90.2 133.5 131.1 178.9 135.2 139.1 138.1 127.9 148.6 137.1 134.6 133.0 163.0 173.2 211.7 163.3 175.4 177.8 171.6 177.4 171.6 175.0 176.6 184.8 217.1 235.4 190.9 201.0 197.0 200.4 200.2 194.0 206.6 203.8 197.0 239.7 247.3 211.8 2?4.6 205.7 221.6 217.9 207.9 228.6 227.1 -1164- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHTS (grams) OF Fx FEMALE RATS GROUP: V I -1 DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650073 650074 650075 650076 650077 650078 650079 650080 650081 1 8 15 22 29 36 63.6 55.0 64.0 55.9 64.2 58.2 62.0 68.4 56.9 98.5 89.0 102.9 93.8 100.5 96.0 97.6 119.0 93.1 141.6 126.3 151.5 140.8 137.6 131.8 150.3 154.5 138.5 182.5 160.0 195.9 181.0 170.4 161.7 187.7 183.9 167.9 208.0 183.4 233.2 211.9 189.1 192.7 225.1 204.0 193.1 220.8 196.9 255.8 241.9 208.6 218.6 258.9 232.3 212.1 -1165- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHTS (grams) OF Fx FEMALE RATS GROUP: VIII-1 DOSE: 500 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 1 8 15 22 29 36 650083^ 650086* 650087e 28.2 -- --- -- -- 42.6 71.1 --- -- -- -- H4 00 u> 1 1 1 1 11 1 1 i 1! 1 1 1i -1166- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 APPENDIX JJ REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS: Fi GENERATION -1167 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS: F, GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. Footnotes a Sacrificed by design Test Day 15. b Sacrificed by design on Test Day 13. c Found dead on Test Day 3. d Found dead on Test Day 5. e Found dead on Test Day 2. Abbreviations -- = No data. DuPont-5990 -1168- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHT GAINS (grams) OF F a MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 649992 649993 649994 649995 649996 649997 649998 649999 650000 650001 650002 650003 650004 650005 650006 650007 650008 1-8 8-15 15-22 22-29 29-36 1-36 43..0 49..3 43..2 39 ,.9 46..7 48..4 44..6 48 .9 50,.6 42..0 44..1 47..0 43..9 42..9 32..0 46..7 47..5 61..4 65..8 65..9 60..4 66..1 67..0 57 .0 64..8 65..2 63 .8 66..3 69..8 65..7 62 .0 47 .0 62 .7 64..3 67,.7 77,.7 65,.9 58,.4 67 ,.7 63..8 71..6 71,.2 71..9 65..9 65..0 79..3 55..9 75..3 56..5 68..2 64..7 62 .2 71 .3 64 .7 64..8 71..4 64..5 65,.0 63,.9 67 .4 59,.0 70..5 68 .2 46..7 63 .4 56..9 63 .0 61..7 51..2 285..5 65..1 329..2 61..1 300..8 69 .4 292 ,.9 70 .0 321 .9 62 ,.4 306..1 56 ,.0 ' 294,.2 60..3 309..1 77 .6 332 .7 45..7 276..4 68 .0 313 .9 59 ,.6 323..9 51..2 263 .4 65,.8 309..4 57..4 249 .8 55..9 296 .5 61,.4 299..6 -1169- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T G A I N S (grams) O F Fj. M A L E R A T S GROUP: III-l DOSE: 25 M G / K G / D A Y DAYS ON TEST: ANIMAL NUMBER 650009 650010 650011 650012 650013 650014 650015 650016 650017 650018 650019 1-8 8-15 15-22 22-29 29-36 1-36 42.1 50.6 45.3 45.9 41.8 38.5 46.7 48.6 40.0 43.0 52.7 61.6 62.5 71.2 71.1 63.3 58.8 52.9 70.2 58.2 63.6 60.2 65.7 66.1 71.6 76.2 66.3 61.6 57.1 77.2 65.7 63.4 66.4 58.4 60.2 69.7 74.0 70.2 61.1 56.8 70.3 67.4 55.5 61.7 50.1 58.1 64.7 73.8 59.5 65.7 55.4 71.8 50.6 60.7 59.2 277.9 297.5 322.5 341.0 301.1 285.7 268.9 338.1 281.9 286.2 300.2 -1170- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BODY WE I G H T GAINS (grams) OF Fx MALE RATS GROUP: V-l DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650020 650022 650023 650024 650025 650026 650027 650028 650029 650030 1-8 8-15 15-22 22-29 29-36 1-36 34.8 35.3 44.5 43.0 47.8 42.8 42.5 46.5 47.2 39.7 49.1 67.6 63.8 68.9 58.9 65.6 32.7 63.1 65.9 59.5 59.4 74.5 61.5 71.3 54.5 69.0 66.5 69.5 68.1 68.8 54.9 64.8 57.5 75.8 57.2 62.3 54.6 63.5 67.7 67.3 58.1 56.9 60.1 80.9 60.0 66.3 54.4 59.0 49.0 60.5 256.3 299.1 287.4 339.9 278.4 306.0 250.7 301.6 297.9 295.8 -1171 - Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T G A I N S (grams) O F F* M A L E R A T S GROUP: VII-1 DOSE: 500 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650032a 650035* 650036e 1-8 8-15 15-22 22-29 29-36 1-36 33.9 32.6 48.5 --- - 1172- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 I N D I V I D U A L B O D Y W E I G H T G A I N S (grams) O F Fi F E M A L E R A T S GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650043 650044 650045 650046 650047 650048 650049 650050 650051 650052 650053 650054 650055 650056 650057 650058 650059 1-8 8-15 15-22 22-29 29-36 1-36 45.8 50.3 28.6 34.7 53.1 36.4 43.5 45.5 45.6 34.0 34.0 38.2 42.0 39.1 30.1 42.6 51.1 46.7 48.0 36.8 41.1 48.8 40.7 41.4 43.0 40.1 41.1 47.0 36.9 42.9 51.0 31.3 35.2 51.7 25.7 30.7 28.2 31.4 27.4 20.3 33.2 34.7 23.6 36.6 30.6 35.6 29.9 34.9 33.7 35.6 44.1 26.5 10.6 26.0 10.1 37.3 22.6 19.6 34.4 34.5 21.6 15.5 28.5 21.2 22.2 26.5 18.8 26.8 12.3 26.1 26.6 27.5 23.8 12.5 21.6 22.0 20.6 27.3 22.5 21.6 19.9 26.8 15.4 14.5 23.5 157.0 165.7 146.2 144.8 190.4 132.5 159.3 179.6 164.4 160.6 149.6 160.8 155.9 174.0 137.0 146.7 197.2 - 1173- Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHT GAINS (grams) OF F 1 FEMALE RATS GROUP: IV-1 DOSE: 25 MG/KG/DAY DAYS . ON TEST: ANIMAL NUMBER 650060 650061 650062 650063 650064 650065 650066 650067 650068 650069 650070 1-8 8-15 15-22 22-29 29-36 1-36 36.0 16.8 51.2 39.2 43.1 40.6 27.0 35.2 36.8 50.3 41.3 38.2 53.6 61.6 39.5 38.1 41.6 47.3 43.6 38.3 48.4 42.8 29.5 42.1 32.8 28.1 36.3 39.7 43.7 28.8 34.5 40.4 43.6 21.8 43.9 23.7 27.6 25.6 19.2 28.8 22.8 22.4 31.6 27.2 12.2 22.6 11.9 20.9 23.6 8.7 21.2 17.7 13.9 22.0 23.3 137.7 179.0 181.2 155.3 166,7 149.8 168.0 148.1 145.9 192.7 178.2 -1174- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BODY WEI G H T GAINS (grams) OF F2 FEMALE RATS GROUP : VI-1 DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650073 650074 650075 650076 650077 650078 650079 650080 650081 1-8 8-15 15-22 22-29 29-36 1-36 34.9 34.0 38.9 37.9 36.3 37.8 35.6 50.6 36.2 43.1 37.3 48.6 47.0 37.1 35.8 52.7 35.5 45.4 40.9 33.7 44.4 40.2 32.8 29.9 37.4 29.4 29.4 25.5 23.4 37.3 30.9 18.7 31.0 37.4 20.1 25.2 12.8 13.5 22.6 30.0 19.5 25.9 33.8 28.3 19.0 157.2 141.9 191.8 186.0 144.4 160.4 196.9 163.9 155.2 -1175- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BODY W E I G H T GAINS (grams) OF F x FEMALE RATS GROUP: VIII-1 DOSE: 500 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650083^ 650086-b 650087e 1-8 8-15 15-22 22-29 29-36 1-36 --- --- -- 28.5 --- -- -- -- --- -- -- --- --- --- -- -1176- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 APPENDIX KK REPRODUCTIVE TOXICOLOGY INDIVIDUAL FOOD CONSUMPTION: F, GENERATION -1177- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL FOOD CONSUMPTION: F, GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. Footnotes a Food consumption was inadvertently not measured on Test Day 1. b Sacrificed by design Test Day 15. c Sacrificed by design on Test Day 13. d Found dead on Test Day 3. e Found dead on Test Day 5. / Found dead on Test Day 2. Abbreviations -- = No data. DuPont-5990 - 1178- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 I N D I V I D U A L F O O D C O N S U M P T I O N ( g r ams/day) B Y Fj, M A L E R A T S GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 649992 649993 649994 649995 649996 649997 649998 649999 650000 650001 650002 650003 650004 650005 650006 650007 650008 1-8 8-15 15-22 22-29 29-36 1-36 12.5 12.1 13.1 12.1 13.9 13.5 11.6 __ a 14.5 11.5 13.1 14.3 12.3 12.5 10.4 12.8 12.7 20.1 19.3 21.6 21.0 20.9 22.0 17.9 22.5 21.8 18.5 20.2 22.4 19.7 18.2 16.0 19.6 19.8 26.5 26.3 28.6 25.7 26.3 27.4 24.8 29.4 27.3 23.8 24.8 29.5 24.2 26.0 20.6 25.3 24.6 29.0 29.8 32.2 29.8 31.9 29.1 26.8 32.7 31.0 26.7 29.1 31.0 26.0 27.8 23.0 27.7 27.2 30.5 33.3 34.3 43.1 35.4 30.4 29.2 35.8 36.8 27.2 33.6 34.9 28.8 31.8 25.4 29.9 31.7 23.7 24.2 26.0 26.3 25.7 . 24.5 22.1 __ a 26.3 21.6 24.1 26.4 22.2 23.2 19.1 23.1 23.2 -1179- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 I N D I V I D U A L F O O D C O N S U M P T I O N (grams/day) B Y Fi M A L E R A T S GROUP : III-l DOSE: 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650009 650010 650011 650012 650013 650014 650015 650016 650017 650018 650019 1-8 8-15 15-22 22-29 29-36 1-36 11.7 12.5 12.1 12.3 12.7 11.2 12.7 13.2 12.0 12.5 __ a 18.3 19.0 20.2 20.5 19.9 16.5 19.0 21.7 19.0 21.1 20.1 23.2 24.6 24.9 26.6 . 23.9 22.0 22.4 28.3 26.1 28.0 25.1 25.5 28.3 26.6 32.4 28.2 25.7 25.9 31.5 28.0 29.2 28.4 26.8 31.0 31.6 37.7 30.4 28.2 27.1 33.3 29.6 32.0 31.0 21.1 23.1 23.1 25.9 23.0 20.7 21.4 25.6 22.9 24.5 __ a -1180- Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx MALE RATS GROUP : V-l DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650020 650022 650023 650024 650025 650026 650027 650028 650029 650030 1-8 8-15 15-22 22-29 29-36 1-36 9.2 9.9 11.9 13.1 13.4 11.3 11.9 13.3 12.7 12.6 15.3 19.6 18.7 20.8 19.7 19.8 15.0 21.3 21.3 19.3 19.4 28.1 24.1 26.9 22.9 27.6 23.2 28.8 27.4 25.2 22.7 29.8 27.0 30.3 24.8 29.2 24.6 31.0 31.5 29.9 25.1 33.2 29.6 35.3 29.7 33.3 27.3 32.8 32.5 32.7 18.3 24.1 22.3 25.3 22.1 24.2 20.4 25.4 25.1 23.9 - 1181 - Company Sanitized. Does not contain TSCA CB1 H90--2D47a6y8G: aSvuabgechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx MALE RATS GROUP: VII-1 DOSE: 500 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650032^ 650035e 650036* 1-8 8-15 15-22 22-29 29-36 1-36 6.8 16.0 -- -- -- -- 8.9 -- -- -- -- -- -- -- -- -- -- -- -1182- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 I N D I V I D U A L F O O D C O N S U M P T I O N (graxns/day) B Y F x F E M A L E RATS GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650043 650044 650045 650046 650047 650048 650049 650050 650051 650052 650053 650054 650055 650056 650057 650058 650059 1-8 8-15 15-22 22-29 29-36 1-36 13.5 13.1 10.5 11.5 14>.7 11.6 11.0 __ a 13.0 10.7 11.7 12.7 12.7 10.5 8.5 11.7 15.1 20.0 19.4 15.2 19.8 19.9 16.9 14.7 17.5 17.2 14.9 17.2 17.1 18.2 17.5 13.3 17.2 20.6 19.2 21.5 18.3 19.6 21.2 16.4 18.7 20.5 19.0 16.7 18.8 20.6 18.0 18.6 19.8 19.2 23.6 21.4 20.8 20.0 19.3 21.4 17.7 17.0 22.4 20.9 16.9 17.8 20.5 17.8 19.5 16.4 18.4 22.9 21.4 21.2 20.0 20.1 24.1 17.1 18.0 26.6 21.9 18.2 19.0 21.2 18.4 20.6 17.6 18.4 23.6 ' 19.1 19.2 16.8 18.0 20.2 15.9 15.9 __ a 18.4 15.5 16.9 18.4 17.0 17.4 15.1 17.0 21.2 - 1183- Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY F FEMALE RATS GROUP : IV-1 DOSE: 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650060 650061 650062 650063 650064 650065 650066 650067 650068 650069 650070 1-8 8-15 15-22 22-29 29-36 1-36 10.8 6.5 12.9 11.7 12.8 12.0 8.2 11.6 10.9 10.8 __ a 15.9 17.7 22.0 16.7 16.9 16.6 15.2 15.8 15.6 16.4 16.1 16.0 21.7 22.6 18.4 18.6 18.2 19.6 17.5 18.5 20.0 19.9 16.7 24.3 22.6 19.6 18.8 18.0 19.7 18.5 18.1 22.2 20.3 15.9 24.3 21.9 19.2 19.3 17.6 21.1 18.2 18.4 23.8 21.7 15.0 18.9 20.4 17.1 17.3 16.5 16.8 16.3 16.3 18.6 -- a -1184- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 I N D I V I D U A L F O O D C O N S U M P T I O N ( g r ams/day) B Y Fj. F E M A L E R A T S GROUP : VI-1 DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650073 650074 650075 650076 650077 650078 650079 650080 650081 1-8 8-15 15-22 22-29 29-36 1-36 10.9 9.3 12.1 11.6 9.7 11.0 10.5 13.8 11.2 16.4 14.7 17.6 17.5 15.8 15.4 18.1 17.9 16.9 19.6 16.9 22.0 19.7 18.9 18.1 20.5 18.8 18.1 19.3 17.3 24.3 21.2 17.1 19.5 22.3 19.0 18.4 20.9 18.5 24.0 23.1 17.7 19.3 24.8 20.7 18.8 17.4 15.3 20.0 18.6 15.9 16.7 19.2 18.1 16.7 - 1185- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________ DuPont-5990 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx FEMALE RATS GROUP : VIII-1 DOSE: 500 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 650083e 650086e 650087^ 1-8 8-15 15-22 22-29 29-36 1-36 8.0 -- -- -- -- -- - 1186- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 APPENDIX LL REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS: Fj GENERATION -1187- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________ REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS: Fi GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. DuPont-5990 - 1188 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Fx MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 649992 649993 649994 649995 649996 649997 649998 649999 650000 650001 650002 650003 650004 650005 650006 650007 650008 PREPUTIAL SEPARATION COMPLETE S ACRIFICED B Y D E S I G N TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED B Y D E S I G N TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S ACRIFICED BY D E S I G N TEST D A Y 40 PREPUTIAL SEPARATION COMPLETE S ACRIFICED B Y D E S I G N TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED B Y D E S I G N TEST D A Y 40 PREPUTIAL SEPARATION COMPLETE S ACRIFICED BY D E S I G N TEST D A Y 40 PREPUTIAL SEPARATION COMPLETE S ACRIFICED BY D E S I G N TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S ACRIFICED B Y D E S I G N TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S ACRIFICED B Y D E S I G N TEST D A Y 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DE S I G N TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRI F I C E D B Y D E S I G N TEST DAY 40 26 26 25 25 22 22 22 22 22 22 23 23 23 23 22 22 26 26 24 24 24 24 25 25 26 26 22 22 27 27 36 40 23 23 25 25 -1189- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: III-l DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 650009 650010 650011 650012 650013 650014 650015 650016 650017 650018 650019 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIF I C E D B Y D E S I G N TEST D A Y 40 PREPUTIAL SEPARATION COMPLETE SACRIF I C E D B Y D E S I G N TEST D A Y 40 PREPUTIAL SEPARATION COMPLETE S A C R I F I C E D BY D E S I G N TEST D A Y 40 PREPUTIAL SEPARATION COMPLETE S A C R I F I C E D B Y D E S I G N TEST D A Y 40 PREPUTIAL SEPARATION COMPLETE S A C R I F I C E D B Y D E S I G N TES T D A Y 40 PREPUTIAL SEPARATION COMPLETE S A C R I F I C E D B Y D E S I G N TEST D A Y 40 PREPUTIAL SEPARATION COMPLETE S A C R I F I C E D B Y D E S I G N TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIF I C E D B Y D E S I G N TEST DAY 40 26 26 22 22 22 22 25 25 26 26 26 26 27 27 25 25 26 26 25 25 23 23 - 1190- Company Sanitized. Does not contain TSCA C8I H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Fx MALE RATS GROUP: V-l DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 650020 650022 650023 650024 650025 650026 650027 650028 650029 650030 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIF I C E D B Y D E SIGN TEST DAY 40 , PREPUTIAL SEPARATION COMPLETE SACRIF I C E D B Y D E SIGN TEST D A Y 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIF I C E D B Y D E SIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRI F I C E D B Y D E SIGN TEST D A Y 40 PREPUTIAL SEPARATION COMPLETE A L O P E C I A R I G H T F R O N T P A W (S ) SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRI F I C E D BY D E SIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRI F I C E D BY D E SIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRI F I C E D BY D E SIGN TEST D A Y 40 29 29 23 23 26 26 26 26 25 25 27 27 25 25 40 40 23 23 25 25 24 24 - 1191 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S I N Fi M A L E R A T S GROUP: VII-1 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 650032 650035 650036 NO ABNORMALITIES DETECTED SACRI F I C E D BY D E S I G N TE S T D A Y 15 NO ABNORMALITIES DETECTED S A C R I F I C E D B Y D E S I G N T E S T D A Y 13 NO ABNORMALITIES DETECTED FOUND DEAD TEST DAY 3 -1192- Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 650043 650044 650045 650046 650047 650048 650049 650050 650051 650052 650053 650054 650055 650056 650057 650058 650059 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE S A C R I F I C E D B Y D E S I G N TEST D AY 40 VAGINAL PATENCY COMPLETE S A C R I F I C E D B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIF I C E D B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIF I C E D B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIF I C E D B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 ALOPECIA BOTH FRONT PAW(S) VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIF I C E D BY D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIF I C E D B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIF I C E D BY D E S I G N TEST D A Y 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE S ACRIFICED B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRI F I C E D BY D E S I G N TEST DAY 40 88 99 14 14 12 '12 99 11 11 15 15 14 14 11 11 8 22 13 13 14 14 13 13 99 12 12 11 11 10 10 88 -1193- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: IV-1 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 650060 650061 650062 650063 650064 650065 650066 650067 650068 650069 650070 VAGINAL PATENCY COMPLETE SACRI F I C E D B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRI F I C E D B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE S A C R I F I C E D BY D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE S A C R I F I C E D BY D E S I G N TEST DA Y 40 VAGINAL PATENCY COMPLETE S ACRIFICED BY D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE S ACRIFICED BY D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE S ACRIFICED B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE S ACRIFICED B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE S ACRIFICED B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE S A C R I F I C E D BY D E S I G N TEST DA Y 40 10 10 11 11 11 11 15 15 12 12 88 15 15 12 12 12 12 11 11 11 11 - 1194- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: VI-1 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 650073 650074 650075 650076 650077 650078 650079 650080 650081 VAGINAL PATENCY COMPLETE S A C R I F I C E D B Y D E S I G N TEST D A Y 40 VAGINAL PATENCY COMPLETE SACRI F I C E D B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRI F I C E D B Y D E S I G N TEST D A Y 40 VAGINAL PATENCY COMPLETE SACRI F I C E D B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED B Y DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED B Y D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE S A C R I F I C E D B Y D E S I G N TES T D AY 40 VAGINAL PATENCY COMPLETE S A C R I F I C E D B Y D E S I G N TEST D AY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DE S I G N TEST DAY 40 14 14 13 13 15 15 12 12 10 10 10 10 13 13 88 99 - 1195- Company Sanitized. Does not contain TSCA CBI H90--2D4a7y68G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S I N Fj. F E M A L E R A T S GROUP: VIII-1 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 650083 650086 650087 NO ABNORMALITIES DETECTED FOUND DEAD TEST DAY 5 VAGINAL PATENCY COMPLETE S A C R I F I C E D B Y D E S I G N T E S T D A Y 13 STAINED PERINEUM YELLOW w e !t P E R I N E U M LETHARGY WEAK FOUND DEAD TEST DAY 2 11 11 11 11 11 11 -1196 - Compny Sanitized. Does not contain TSCA CBI