Document rpOnzk4xMnxdDeyjvvqm0qr0v

i .... JilT 0 tv l !i \^.'U vp PAG!'.; 01. :,0 ;\111 L n .. By Judi:".; Tondri MurNe**!* f Writer unrelated to vinyl ch'ok e inay explain the dif::: - Accum-latin;-. evidr* re is enccf. But he emphash ed 1;:b'.er.irw, the suspicion! that the possibility taat !', 4! 'he plrstic pol-vvin;! [ exposure to the. chemical chkmiJe -- eltetcy linked.j: may be rcspcnsio.'c is also to imcxpectcdly large nr.m- j; very real. 11c is now in the ba:t' a rr.i e form t f 1:' r-1 j: process, he said, t' deter c: . re: -- m; y a'so be mining the precise nature of jiv. y..cated in c aw;2 ; biiu'i the birth defects in question J.GG'-. to see if there is any paitcr 'j i.e evidence is : -yarded of uniformity. ;.t prelim' ry but is suffi- Meanwhile, Dr. Irving J. ciei "ly <d. v;iclin(e to be hclikoff of the Mount Si..ai pram,dir.;, e, flurry of scien School of Mubcine in New tific : iy,; jn, both m York, told the environment and evt cr rrnmaty, in saber:..mitt-. 0 in the Senate United l-tnlr:. and a ! ycste-J; y that a gradeam i'.e'. G rr oi other countries j student colleague had vli--"-. billion. ` to;:? of bite e xt - it::.: Cu th, v .e bit .1 plr I c " rr.aae for many cell:, of 11 men v. skin;; :;i tve:-; rhycni. vinyl chloride iv.-.nts a-.d every m:,1, sc- for, the found ahttorm: chromo d0;t:'vr y is ;jp, .c-j.by can?- j somes in more 1.: tlie sam Cu by ini; :';i; of vinyl 1; ples tit m would have l)cen c!I : k-r ; rs. Tb gas k o..pr.,ed when t.,e findings uv ir. the menu; -te- - af ! \.`ere compared with those li,e . olid c i i- ..S 1 of 10 men matched for ;,;,e pol;, . h yl c;..:.1 r ; J; .11 and other factors who he.) re- there i the icr..i of no: bee-, occupationally ex residue.-:. posed to the chemical. At the Ohio State Depart Chromosomes are the ment of Health Colum- , units in the nucleus of every j[i : , example, iPeter i cal' -- tncivJi: a the c;;r;r. l; J; : to of the divi. ion 01 chrome cu case?, I.r 1:1 th-_- i aaf sr,- *m -- that tr.-nsir.it . L-wiily . bar-cteristics from lest sc . rial \ rchx cxairi- : ir.i (! f .: vital statistics throe c :n- ( mtm:' tn the state r0 |! 1 Ijc i 0 ei rc vinyl clilo21 uc 1; plant . 1, JUG DDAMINADO ii the iv 's has, ditcl of Sll T link, v.n .? the 1570 ik/3 rtite of such defee; the slate as a whole \`. ..s 11. , per 1,000 live births, th. rate in the thiee cornu'.uni- . lies -- Ashtabula, Lake Avon and PeinesviUe -- v,-.;s a.!- t-st twice as pre-ot. Ir. a te'r niicue intcrvicv., r.w ;tn sr.cd tbnr rnii-;.-? one nenerr-.tion to the next. Thus, if the chrom : omes of ci'.licrparent arc not intact, there is a real possibility that any offspring of the union will have a birth de fect as ti result. Sviikoff h.-r- done much of the scientific detective worl: Jinhin,: vinyl chloride lo nnf'iosarcomas (the rare cancers) of the.liver. He h.-s also recently question ed men at two plants -- one owned by Union Carbide, the other by the Dow Chemical Co. -- where polyvinyl chloride is mu> about the stiliuirths nt.d ;:.: s c a it i a pes experienced by their wives. "J TEDL an uneasiness because of the- apparent inerr 0 in these stillbirths and mi;carriages," Selikolf told a reporter alter yester day's hearing. "Tin e are plants whe: many .''.enti ce!? arc mace sc, that expo^ure to subste.-ces other than vi: . 1 chloride or in deed factors urn elated to employment n.ny be to blame. Never*' c-lcss, this is a lead that ust be pur sued." Should proof posi:' e develop that vinyl ckicr.de causes birth defects, many scientists v.odd. not be sur prised. It has become in creasingly apparent from the work, of several labora tories th;t substances which can v cancer fre quently fire capable of damaging tire fetus .- s well. Morc- ver, some of the data on angiosarcoma -- the cancer linked to plnr.bc manufacture -- suprests that c heightened risk of tumors may have existed from birth. One of ever., four case? of angiosarcoma in Sw.-den, occurring between 1 vDJ and 1969, for example, uv;. found in babies. .And, in addition, the work of Bi. Ceasarc Maltoni of Italy, the sci' *stist who did much of the original iaberatnry work on vinyl c. loride in anii. als. clearly demon- sira*., d that wl-.en pregnant rats were e::p* sed : the gas, many of : a p-os de- vclo;. 1 anpiosatco:. . Moic recently, sr .ntist at the University of Stock holm in Swed .1 have bee; 1 g st ins salrtonella etcriu m determine ether 0: g them to , inyl chk..^e censes changes in their : enetic traits. Tiie tecb.ni; e, d.i^ veloped by Dr. iiru. Ames at lie University 0 1 Jikr- 1. ,, Berkeley, is ; v.r.MlLd ; particularly sc: itive. in : .ri.inc out b.alcgicai ' ' ior in lower ertt. .isms that is predicts r- of similar biological behm. ior innran. TIIE SV/EDIS work has. been publu .-d m Mr-'':r.h. It reports t: .t expos. to OLI 2040 2 DAO v 7' hr hey Cucrlio;;, / V ;1 : a tclephor; in; j V U v. he the r h". ::.. 'i c * ; : to t h f ell. . f . i1 he perm or i : 'O- (' u live cells so that tlicy ;hc altered when a pre-jj- lit'-.? cy is cc . em u. - Yesterday's Senate hi ear in?: did not resolve th is is.-.e e. However, Dr. do scpii \V. rener, a rtevernt pent tc ic -mist for bed: the N'a- Uo. ..1 Institute ,: dee unatin.*::.l Sc.fety on i He ,,iri a;. J t'';.: C'enicr for Dii . . t,. ( t:v! h: Allan!;-, re jn. Wad t! , ; a study will soon r<'.tc u.;J way which may pro- v;J:: the answer. T study, lie raid, is to be ii,,.:v for beamy p :-.rior P- so:.. .1 who have had Ion; an , ' listen; exprsu: e to hr.ir;.;':. ys. Vinyl clilorid:? W CvOt; hied IP the prcw!!;: r-f 1 hr.ir- sjo:.>y-!.:.;i nbc.Jt Is?; until ember this ye; 1 > hen it pa; : 'id c:ar yens be. cm knew Mc..r. while, another vrit- nc's at (he hcvrri;:.; - !'r. Robert Schafir.er c-i me T'uz.1 and Dr up /.diriinisirn- tion -- told of recent evi- dcr.r: that -- besides bein'? inhaled -- some vir.yl chlo ride inny have pottc;: into the fo:;d supply. TTZIGm HAV2 shown. Pchnffner repuricci, that the cheinif.il is capable of "mi- Cratirs" out o' plastic liq uor bottles 'or fir:sirs into alcohol and cut of the plas tic containers in whi-~h food products, such as some coohir.;: oils, have been sold. Standards soon to be pub lish ' in t/.-D Federal Kr;;i: - ter, lie tr.id, ' ill " ^J,. * n. t s i * ^,,r............... .... i' ` , .. i"r pl.v tic ft '-d cos;..,', of j.a r.'s ic' ' .It chc iC;.t. Rut ; ''- , he : Jniiticd, is th ; :r y such materials h: : been produced for year. . No feeding studies have bee:; done on animals to u mr.;'- struts whether tobine vh chloride by mouth ir. as cl Ccrous as brcai;-:; it ap pears to be, be c:-:pi ;, !, but the possibility c;be ipnorcih All of this caused s; hrr.v 'mitico Chainn;.r, fen. Joi n V. Tur.ney. D-Cr.i.b , to cc went: "'iberc has m I:.- a belter way of tc: mindin'; potentially to matcrish. in food -- tl;c a so, : s in this case, v....-n no ter;-, have been done ir. v'-s ru\ on the posablu impact cn public her It is." OLI 2041