Document rpEG9oVm9YEvndwLyJpv45NG
v- *' f.>uv/ IC.PJNI MU
' Younger Laboratories
BbcJ--mtiti ... Pi*o*mac*l*iUU. .. AnalpiU
1*0 CMrrCAV* ROAD Mr. LuDU *. MiaanURi
GeAtijficale. oj Amlyiti.
CUBJBCT -
Toxloololo*l Inroaligation Oft (toMutt tw^li Naabor 21 NoMAT.to fTOjOOt iMbtr I*i>ll
Pjruol 1470
Harok 4tb, L96)
STVDT CONDOCT0 TO* -
..
HmmN Choaltal Coapuj, St* Loalo, Rlaaoorl
y \r
V;
BroiNorru nocsctt -
A) 0ml U> (Soto)
. ' i- . .'
ri wriUitH ooapmiad n< fod by atoaaoA uti to 4profit# Sooloy itnli albino rata.
Aftor tho approxlaato ttlaiaiM lothal Dooo ooo dotorUaod, groupo of aalo and foaalo roto ooro fod la lorra*iag doooo at lacroaoata of 0*1 motional log latoroala at foar lovola doaigaod to blanket tko toxicity rang# thereby oapply* ia lata for ealeoUtioa of tki Utv Aloh aaa doao oooordiaf to a aodlfioattoa of the atho4 of I. J. 40 Boor*
Oboervatieaa ooro node for toil! eyaptoai ao4 the riooom of the aaiaalo that ooooaabod ooro oMalaod aaoroaaapioally*
fho 4ata aro oBooa ia Tablo f* . .
S) Shi* Ataorrtloa KLft (labbite)
.
71m aa411to4 eea,<oaad oaa applied la ieereaeiag 4oaoa at laeroaoata of 0*2 fractional log Latoroola to the oloaoly elipped, latoot akin of Boo Zealand
outa foaalo rabbit**
. fBa treated oroao ooro oo*oro4 vltk plaotlo atrlpo aa4 tfc aaiaalo plaoo4 ia aooAoa atoeke for poriofo op to treaty-four bear*, aftor Miih tlao they ooro
aoeigaed to iadlvidaal eegeo.
Obeorratioae ooro aa4o for taxi* eyapteaa and Uo rleeero of the aaiaalo that aaeeeabed ooro oaaataod aeereeeepieally*
The data aro eheea ia Table 11*
-`
if wpoM boat* to om4 le mt hm f #d<
1*1 NMHtt Cbaoloal Ca> iu iMli, NUwirl
lMi|r UMnurWa Cartlfloata f
Vaa 2 <W*5) T-vn
OPUlKOtTAI. PBOCU>VU - (Coatiaaod)
C) Sbla IrrltoUoo (tobbita)
Tba aadllatad eoopouad ** appltad to tn ellppod, tauet Min of aibiao rabbit# ui raoovad oftar tvaaty-four bjura. Tba `'ppUeaUoo a* aoaarod alia plaatio atrip* to riuri taaporotioa*
Obaarvotioaa aara oada oaar a pariah of aararal day# for irriutloa.
Th <iU, aaertd aaaerdlitf to tba talked of 0rala, toodard aad Calvary Uouraal of Pkoro. ad *jcp 7h*rpaatloo, Velata 62, Paaatbar, 1944) ar abovn ia Tobla 111.
0) lya trritatioa (tobbite)
0*1 NllllHtar af aadilatad oatpla aoa plaatd ia tba eoijuactiaal aa f u right aya of aaah of tkrta ilklM rabbit# ud akumtleu tad# mr pariad af aararal da/a for iAfluntlw*
til oyaa aara riaaod rlth van laetoaia aaliao oolotiea aftar toaotyfour ior*.
Tbo data, aaorad itetrilii to tti talked of Drelaa, at al, ora aboaa U Tobla IV.
t) Vapor Jakalttloa (lata)
four I50grat aala rto *art placed La a glade desiccator, 2$0 m ia dlaaatar, aad
oapoaed for alx hour* to a aoaaoatratad otaoapherd of vapor# produaod by paaaiag a
atraaa of air through *00 ailliiitoro of tba aotpauod aoatoAaad ia a 29Cb-aUilllltar
tali far* goo vaehiog bottle oita frit tad dlae* Vapor# froo ta# aottlo pasoad
late a oa liter aottlo to reteae droplata aad Uoa into tba chaabar* Air flat
through tha aaaplt woo 6 lltora por aloota aa aaaourad a/ a calibrated rotaoator*
Thie oaa aeffialaat to vlolaatly agitata tbo liquid. Ho aupplataotary axr aoa
Utreduced tnoatuob ra tba abort mpply
?! for tba ommIs axyaa raqulraaaata.
Tba oAiaolo aara obsaraad for baherlor u4, alaao tbora aara ao daatba, all *ara hold (or taa da/o oboerratioa.
Tba data ora abort ia tablo V.
imuti -
tKKfUItt
A) Orol L0, (lato) tha Oral 16^ for tale and fatal# rata vaa plaeod at WJO allllgrooa par hileyra* ottb losar ead appor lltitt of 1990 to 299) ailll*raoa par xllvina. tha loapaui alaaoad ao slightly toxla b/ oral iogoetleo ta aala aad fatale rota.
V, data dboorpttoo KU (totalta) Tha KtaiMt iatftol Ooaa by Skim Ahaorptloa ta fetal# rabbi ta a faaad to ba groator than 2000 ai.iisraae par kilograt oed laaa tnoa JlbO tlUlgraoe par kilograt. Aoital p} doaad at *OJO eiillgraaa par eUegraa, vary nearly auceuthed.
Tbo ceopoubd aaa alaaoad ao slightly toxic by akia abaorptio# ia fatal# raobtta.
Muirnm^) m ipppy:,"
l"!nrp'ew*we" yv>w NQNS 036436
U7WU11 - (CaattaaM)
C) IUi IrrlUtiaa (kkklU) th* iMptud mi alaaaad aa a m4inU akin Irrltut. Tha *tar*|a aulaM aaara aaa 4.6 out af a paulkli la tmtrfMr feovra*
) Kya IrriUUaa (pabtlta)
Tba mpaul aaa alaaaad u a aodarata aya irritant.
Tk a*raa msUm acor* aaa
wt of a poaalal* 110 U aaa hour.
1) Vapar latalalia* (Kata)
All aaioala wrrtfii Ui als boar aspaaara aa tall aa tka faUaiiif laa 4*y
kiimtlM parlod.
.
It aaa anaalu4a4 that fcbo vapora aara aliiktl) koala uadar aondltloaa af th:
Bit ran n. ioma
Tha ia thi rapnrt ; to h* atari (a 'da*rtpar*t af
the prodact an*J na (m y :**# to r^.p^o* bta mW evatart*.
VitHlatatiUi wmI tjr
in idvauiiii copy. Tba
ao>;rca af |W nut* fwli* -*1l >< riivtflfari anti) it appear*
tafanaa) puhU <**.na. No** i-mmi w>tSaruWi*bad rula
nay W
M'in. Mt ;.> aa"-->>il of tha Madtoal ttaparp
Mint (a St U*u>'< l' .H-'m+n' incaifiea fi*rdlf aiuvn of
taakitv arc t Vm tr(**r*i br'.ara to kb* Mtaioai Depart'
Mil in Sr Uw*> far trtlf.
-- MoruMn'a Om*L'*1 Ccaapaay
- MONS 03641!
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tM H*a*uU Chooieal Co4ty
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It* Ltilit NiMrl Iwur Ukrtrlao C*rtl/Wt of AMlyoio - r>| > < VV*5> - I-6V11
Tails 12
T8S HINXOTN UfflUL DOSE or 'Pyraael 1470' IT SKIN ABSORPTION XI IAMXTI
aoplo Applied Omd llotd
isiftijs:.:.?!!
1 - rMi 2 - rma 9 - rti 4 - rMi 5 - Xml* 4 - FooaU
olckt JXi.
2*5 2.2 2*9 2.4 a.9 2*5
Ooco
TM 1240 2000 9U0 9010 TT40
eight Choice 9 Doyo Lotov _____ Ui______
- 0.1 0.1 - 0.2 - 0.J - 0.2 - 0.4
________ftU________
Sinld DirriTM lr*lro4 Mol - 10 Mjo Md - 7 Ooyo Md - 7 Doyo
DX4CUUI0H -
Tk( WAfci-- Lilkal Om hy Ski* ttMrptlM ia fwil* ntbiu mo fouad to k (rutir Um 2000 adxlicroao por kllocrai ia4 Xooo thu 9l4o 4lU|nat per kilo*roi Adoal #>, coad a 3 2000 Ulifrooa pr kllograii very icarly Tbo ooopoul u eUaod allfhtly toxic ky akii atoorptloi la fcaolc rtkklU.
IvrvlHl Um m m?m to tea 4ayo> Tfilt oyoptooo iocldd loco of appetite, liUirn, m4 laeroaoiac iHkitu. Iltkt leaooa ru to forty per coot of etarttM oclht* At aotepay there oaa liver lleeoleretlea ooi roaal hypercole oaoroocopically.
fc W.r lit
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Vv > i{".
iuynii j-i .Min), wiwn mb 1
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HONS
036419
itm in
ittmtio* in u*ra irra arrucanoa or 'rrroa.1 uio-
taapia tpfiixi imiiiM
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15 2a J3
warlua miKttia t Th tad Of
iSaJwM JO?vr#
54 43 54
5 2 2
2 1 af
isi.tnn
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2.4 4*4
3.4 2.3
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M4CU4SX0M -
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lk< iMpoud m iluad M4rt'iklB lrrltoat* Tli *n|t miIhi Mon M 4*4 ot of i poaolNlo I la
hoara*
.
Itll*dflat4 radiiw with 1117 allfkt idwt 4orlop4 aitlila u kaar for m artrafo aura of 2.4 Mt of o peaalklo 4* Ortml|ht tooro 000 ooll*4ofloo4 to oo4roto irjttaaa and ollffet *4om Uermlaf tut atirafi ooora to 4*4* No tllotorlM m okiirrid. laflaaoatloo groNoolljr roaatad follooiog rnaoral of tko oppllcatloa. Aftor a*fM 4oyo oao aalaal mi ftvoo a ocoro of aoro toot fir; ollgOt r4aooo 000 till proaoat 00 tfco roaolaiac aalMiU*
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HONS 036420
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,ht NimwM einiMt CW|aargt. Uata, Hlaaaarl
Ta|*r UkonUru* Cartiftaata f Aial;tii
Pag* T <W4J> - T-43-11
yiiu n
m IMITATION IM UUIII Ann APPLICATION or ^rusl 1470'
gaapla (0.1 tUlUlitar) Appllad Oadilatad
hawrinl tvalaatlaa At Tha tad Of Usir - ISJtm. U.iarj . li.imt. i$.lmt.
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35 7( 17 12
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21 21 ' 13 4
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35 50 20 12
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DISCCUIOM -
Tha CMpeuid m <1im4 M a M4*ltU aya irritant.
Hi itn|i
or
wil f p*mU1i 110 1* ana havr.
.
1hr iatamittaat pawlag at tha ijim for aaaaral aimtaa fallawlag appliaatiaa.
Aftar mi tear Ida atari** aeara *aa 3?.f m! af a paaaibla 110. Slight adtaa, alight ta aadarata radaaaa af tha aaajaaatiraa* aopioua diaaharga. aad alight iria aeagaatioa datalapad* Tha earaaal araa alaand aaaaafcat la taaatp-faar heara aad althU fiaa day* Iria aad aaraca aara aoraal. Caajaaativitia aad adaaa alaarad aoNglataly iltlU aavaa daya.
1
i HONS 036421
It* LMlit UiMri Tok|r Uhvrvtvri** C*rttfl*vt* *f AuljfiU * tag* I (W*$) r-^U
1 I 1 I. I f IHHAIATION or 'PyrtaoL 1470* VAPOKS IT AATS
imi T*Mp*r*tvr* 1mU Chtaktr........................................... ........... A*r*g ItUtivi NiiMikr UiU ...........................................................
70* f. 42 %
JMSl.fti.-JH ..ft!*..
1 Ikl* 2 Ihla J - Half 4 - Ml*
larrltai l*rrl*tf lrft*4 tarti4
OtMfloaal pa*la at th* i;n la taa to flftaaa aUt* ...
light aaaal dlaatarga ... laaatfMaafart ... la raal vaakaaaa * Oaaaalaaal lrr*gUr towtklif.
DlftCUSSION -
'
All aalaala aaratvat ika ala kaar aipaaara a* vail aa tha fallavlag taa lay akaamtlaa parta4.
It mi iMladto that th* rifora vara aUgttlj tosla aalvr oa4Jtio* a/ thv laal.
Thv vapara prviaaai *1M aaaal sa4 *y# U/laaU v*ll * mm* 4l**Mfart. M* imuim of aouaquaaa* vaa aot*4 *t th* *a4 *f *spamra iM aa broachlal ralaa AavalapaA.
Aatlvitr aa4 *rr*tlt ratanal tv aavml withia taaalrfaw heara. flaaal lafla--ilia Aiaappaarai vlthla imatrtoa hwrv. Nv rvaplratvrr aoapllaattaM gavalapaA Aarlag thv taa ay vhvvmtlva p*rio4.
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