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FILE NAME: Smoking (SMOK) DATE: 1955 DOC#: SMOK027 DOCUMENT DESCRIPTION: Book Excerpt - Tumors PATHOLOGY BY Peter A. Herbut, M.D. v 7 Professor of Pathology, Jefferson Medical College and Director of Clinical Laboratories, Jefferson Medical College Hospital, Philadelphia, Pennsylvania 1378 Illustrations on 631 Figures and 6 Color Plates Lea & Febiger Philadelphia 19 5 5 150 T um ors tarH, ydsorooctar(bcohnims naerye ismwpeoeprtsa)n, t pciatcrhci,noagsepnhiaclta, gecnrutsdeinpmetaronl.eumCo, nstahcaltewoitihl, cortehoesrotdeisotiilll,apteasrapffrionduoicle, slucbarniccaetrinogf tahned sfkuienl. oilIsn, hgarleaatsieosn, aonfthtarracdeunset, aanndd fmuamne.s iCs osanitdac(twwitihthouttadr eafinnditeinphraoloaft)iotno opfrotdarurcye fcuamrceins ommaayobf ethtehelucnagusine opfh,aorrynaxt .leaTstarhrayvecosmombeusetfifoenctpolna,yscaancreorleofinthcealnicpe, rtoonfgtuhee, oarbadlocmavinitayl, saknidn iCnhiKnaa,ngarnidusinersCihnutKtaasuhsmerisr, inin InKdaiiaro(luassetrsmienntJioapneadn, pirnodCuhcainnggecaunsceersr ionf tDhheothiacrdancpearlaotfe.thferolmoinsmanodkignrgoincigreasrsultws iftrhomligfhritcetdionenodfssoinot tthheatmaoccuuthm). uPlhaitleipspiinneas loisinducelottho. thBe ettoebl ancucot cparnecseernto,fatnhde oKrhalaicnaivcitayncmer In(odfiathaenldowtheer lpilpa)ceidn nboertwtheeernn Ithnedialipalsaondoccguurms .fromFintaolblya,ccoconmtiaxcetd wwiitthh mlimineertahlatoiliss proAdruocmeasti"cmaumlein-sepsincnoenrssis't" ocfanaczeor.compounds and aniline dyes. While the fitoerlmy ekrnhoawvne tnoopt ryoedtucperocvaendcetroobfethcearucriinnoagreyniscysitnemm.an, the latter are defin in Cwaorrbkoenrsteetrxapcohsleodridtoe itshea ccahuesmeicoaflcoirvrherospisroalonndgienddipreercitoldys.a cause of cancer thaInnoargreanthice ochrgeamniiccalcsomarpeoulensdss irmefpeorrretadntto aasbocvaer.cinAorgseenniicc iasgienntas dmoubmtfaunl cdautceegsorcya.nceSroomfethweorskkeinrswmhialeintoatihnertshamtationptaiicnalthcaotntsauccthwaitchauasrasetinviec rperloa ttioonbsehnipo dhoasubntotthabteeint cparnovceadu.se bUostehd smqueadmicoinuasllayn,dhboawseavlecre,llthcearrecinaopmpeaaorsf tChherosmkiinu.m mByay sboemea afauctthoorrsinitthies parlsooduscatiidontoofcasoumsee ccaanncceerrsoof fththee lulunngg. fforerqusteanttistaimcsonsghocwhrothmaattepuwlomrokenrasryascaitrciisnoammaonigs tahte lgeeansterafol uproptiumlaetsionas. CfinaenrcieesrsinofStohuethnaWsaallessinaunseds inanndiclkuenlgms iinneswoinrkSeursdbinurcyop(Cpearnaadnad) naircekeml orree pizreedvaSlieOnit) tihnadnustthreyyalasroe iisnstahide tgoenbeeraalttpeonpdueldatiboyn.anTinhcereaassbeesotofsp(uplmolyomnaerry carDciientoamrya.disturbances are unequivocal factors in the production of carci netoiomloagiicn saignnimifiaclasn. ceTihnemy ahnavalethaosugyhetc, ehrtoawinevdeerf,ictioencbieespdroovaepdpeoafr dtoefipnliatye gareceonntrviebguettoarbylerso)lep.redAinspiomsebsaltaonctehde dPileutminmeSrw-VedinensonandsynFdinrolamned. (sThhorist iins oatftethnedendasboyphaahryypnexr.keDraiteotsairsyofdethfiecimenocuieths ianndthpehBaraynntxusan(adnlaAtefrriccaanrciNneogmroa tlrivibeer.) aIrne athttiesndceodnnebcytiocnir,rhGosililsmaannd fehdighraitnscitdheencdeieotf ccoanrscuinmoemda boyf tthhee gBlaanntdusisanmdoprreodpurceevdalbenotthincirdrhisotsriisctasndwcitahrciennodmema.ic Cgoaintecrer (odfuethetothiyordoinide deTfichieenrcoyl)e tohfanhoirtmiosniens nionngthoeiteertoiuoslogdyistroifctcsa. ncer is difficult to evaluate psirnegclieseflayctbour.t iItt iiss cperrotbaainbltehatht amt ohstordmeaotnhess arreepdrueesetnot ctahnecemr oosftenimdopgoerntoaunst origin. According to Spencer, "hormonal deficiency may set up internal