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K H 2 O a f* ll. g *i ~ a* * gfl 1 o goo a a -- : 9 * C.OQ O M *o i. ^ 3 n (*f+t a m fl * ui 6 " 2* 3 li c I tjl r n* l n) * !- r \ si i i. 1 i i i X / i. / / I I- ram* r *b(~ cr c Msixon institute, Ptctsbuhgh, Pa. ^ ? 2 i> er P fti a *o a * h> a tt E a C p. . r* 3 rt , O . ** ;? 3 ! fl a x? a ct* < g' ^ 3 -r cn O J H& y* ft- M 2 P * O m p> a v* 3* o o a o' O' ^ 3* h a i-j g* a 3 a o C K tr (a ^ so *; o o m. *t f 05, ^ 2L rf M o j--> OST 3O ^ i 3kQ 2:2. i 2 < o sr ef 3* 3* O p S'* " 2 3 h- a a a SOf `i 2o 2y. _s ^ o O *0 P (XJ o fMO 5* p cl p O 1# ho ft o c* *1 M *1 p pa o h* P* a i cr o' d < a 2E 5c 5o? 23` h> S3* o^ 3 a 3 H h> a _ *0 c* a h> P>o i ~r o S P O I-* O M. c* H O a o P 3 < 1-9 (t ft 3 (R O C' o x *1 e <-* oSBSff*? 22 e&>< S* 3 3 O )-* S f B H* g *t -s a a < ro C\ vo -J' M VO o "?r o S' B P< 1:0 p* if o o o ro C* O *1 r+ O O t_ H* 3 P B* 3 a oq a c a w i m p< % a *1 o \ \ 3 a a oc ^ f' o* a a ft o a o lo-' a a 3 03 M O < o -l rotni rr -r r j K Mniorr Institute, Pittsburgh. 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H* 9 9 9 P9# 0I O 9 O cr o a 4 >4 a r*> 'a da o' 9 H 9 9 **(1 3 S6 aa o3 9i 9h. aa 8-3 3 * ft i g 9 a a cr a . h* 9a Ha 99 4 an + o a cr a ?!! a. :? a 1 n!M m 2 5 s 3 9 ' 5 > a9(CVO* jf^ ft oa 9 gP e- < . wo , ; v- ? ! i tJ Sto I L|--j-s o | * ts *3 S S :fe Hi a vc > r s~ iC_ ^On ri js o j 3 *d*33 1 O Cs H ti O i n / fV K.M, Lynch and W.M. Cannon m Asbestos is : VI A nalysis o f F o rty Necropsled Cases In v a ria b le , fe a tu re o f asbestos is ; th e reason fo r t h is is n o t c le a r &9 the p a r tic le s do n o t reach th e p le u ra . The occurrence in a s b e s to s is o f nodul* fib ro s is , o f s ilic o t ic type, vh ich King and others have produced experitr.en- t a l l ; ' , was co n firm e d in 8 cases. Carcinoma o f th e lu n g o ccu rre d in th re e o u t o f 1*0 cases--an in cid e n ce o f 7 .5 p e r c e n t, w hich is seven tim es greate. N r - rr r Mziiopr Institute, PiTtsinmon, pA. -> n jr Q p p o P 0* e+ t a p *1 P P 3 O 3P =Or CD IS <- ft a* &C e*1 P a "D O c O' e* *a o {+ (9 O' o p p . cb p p 1 3* a P (9 H it *< o p* 3* *t o ft P >0 P Cb PSP* H* 5 P o# P5 ST ct m a* 1 o (S9 o10 P*5 0* H* -* S w* o P p a a * a ga p* oa - 3d- * g-3 a c+- ft P* cr p H* o o cfh* cr ogc o<5 i-D p X H- *a 3 3 *"*> S3 3 <+ cr o erns o 3 H*r a a o a v* a 3 i O i p M. s 0 3 o 0 1-4 n rt- a a 3 -1 n o ** a o o 0 -1 e ,s I- .p v ;o .* .s u 03 . t > , I Ob* 3 CO : c ti i Vi *> c ;bD O 3 i `3 OO K I V CD U !g C C o r rso J* *c u Q) CJ U ^ K }* 0) d O o o t c 3 3 U *J c 5 Cm i. ft o 4 Cm g a H 0 ft, 0 uT-o 3 0o 0 C0D s cI fot 3B *o* o a. o c OR l-t 1-H R 3 0 P s u s C Pi 4* O4 44 44 Cm H oP cO O aU c ft ft O I ft C) I Oo ^ o O -P ft ft _C 'H rt P fot *C H -P ft d c o c aJ O A *W 4J M 3 H U C 3 3 U4> U c o A e O *> 0 U J3 C a, -P A K > *"< f--t V -P *> 33 C C +> 3 a -p 1 u o o C -P < ** 3 C P 3 A Aw x: (4 -- p 0 C A -P o fH 0, c A <H J5 3 o a 44 o <-* B 3 O TJ O 0 u P to 4J ft c <" 2 0 4T4 3 C to O -P e3o crt r A > . i I / \ ^ ) / ' 77 C \ r r \ Memon irrsTiT'T.-'TTt, Prrrsui-noji, 1>a. / r r wmw n O JteiOK INSTTTUTJ5, Prrrantmair. pa. I v- . I 1 / >U*M TT l-- ft-. 7 b? E* i $3 J l! : MEXXON INSTITUTE, PlTTSBUHOn. Pa. c-l 3 . ; *o 5=3r a*" 5fo0 cf p. o T) ea o Oi-j 1(3 OOQ 3 a* a 3S 9 C* >O 9 > ? z J >? H> 9 c* 2* (H o g 3 3* a l-c- 3 n 3 n <o I *t o o to p* >- O >-N S o a o tr n - a m osW 3 fo 3 P. c 2 M Mo *5 a od* **3e5a m m e> VO n 3 0 r m on oo ba Ba* M ` o s ro o 3 8 *"S 5? 3 o o 1 O -> c+ ' O- > s' 9 ro 0 c+ >~l >-{ <* 2T > . 3* o oo e 9 m - a M V* Hi C V* 3 _! s s 1 w c* P. M W *0 M M. o VO P* I u Q a >1 Q cry* l-* i M- ffl VO cf O M. * (3 H -- o 3 ;i * o _ 3 (-* O' 9 " t3 3 n a p w 3* t-* 3 a 3 VJ 9 ct* *< *<J3 a 3 ! i 4 3 I'ff O >* e* *3 5 H 3 a h s p. p 3 B* 3 ! I 1 -p* 1 >-> ziJ !! Ao 3 9 :t / i Tt *e s * z 21 5 > t e E o ss > vn M , cr Msz<on Institute PmsncROH, Pa. O H >4 fl 4 o hjg a tfa Of* < tl <0 a o * i B 1 fl 4) O rfTBKJ ft o e * e *a8t ; a .a ft.' 2 s "1 1 0 * cu * p <. 0 ocu',- P* P + O' . Q f o t* O ct P < 3 <9 a 0 MOW _ M M O tfl 3 P o* m a* C O (4 B ft H & ft s O ft v, O' ef S. B o e 2 h P <9 M M ' 8 .J^SS Sop \X . O 3 P 03 O + } o ^ H* 3 o cr o' m I P a a o b ft Conoco 0 < M cMS p ef O ct O 03 ct- 1 m a s a P -- B < t+ H3 P P O ft o ft s' pt et a ft ft> m a p c+ Bo a> o 3* o sr o 3 p h, o sr or a <3 9 |4B 8 o O O 5 B* <t o' ft b a Mo a o 3 P* g P o* o' 5 S M O' ft- MS.S*3 O M H> M o c* O 3 0.3* UflUQ a <4*9 3 ff > 0 ft 5 a b a (t ft tt 'sr " c- * to $ VJtr 1?? te? T U' O' 0 0] a . > ct a O X V* ft>> (9 a n a M" _ii_ !3 1 ^4 VJ1 I i i i / ) 2lKr.r.oN TnsmTTjTE, Prrrsuunon, Pa. w*l T7 c - >r r 2tX2Xon LvsTrnnx Pittsucroii. Pa. 4 0 i >HV1U IdtfMUMV r \ irlcrxoN LNS'rmm, Pittsbckoh. Pa. 1 / * t ! 1 J i i s 1 I ;J \ i < j -1 .1 1 ,o^ f ^ Mnxoff Institute, Prrranvwon. Pa. I w / romm tj nr / * I Q \>A ** *i * <* 19 S3' _ 3 I> iC in' 15 A 0 1 MstiOK Institute. Prrrsnuttoir, Pa. P n *1 rt O* T* ft 21 w ^ n 3 n o . 0 3X 3* = ~ ?* ft 3O 3 t* ta GO a <r * p ft X '"0 CL cn 3^ E TM o w 3* ft H cpn* y ft ft p* w 3* 0 ta ft I-*ft (A o o c= J HC rr 2 ft 2 ? 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"3 3 -- aq fl n u * 0U> J " _ f> 09 * n P _ r 3- : * *r- -- - S- 2. n a i * . t f 3 o ,, o 1 3 3 <= # n r *3 si n p_s:2~o* o m o* o a. 3 CL' n O 3 a fl c 9 S *< ea ,c* s I > o a p r> (A p rt 3 m* P <9 3 t CL *3 9> 3* Oa n a3 OQ 9M o n p " :> c c. b a n o 09 n rt f - Cun a. 01 n O cr ft . (A 0 (0 Pi 0a1* a w OQ 9 ao - r, 2 ` i9 s 1 a 3 c* ft 01 0 a CO ft 3* p P- T O 01 3Q* CO O* (9 O ft "t ra _ r. co. W R 2c c= ; ft X 19 3 o. a u 1 n 0VJ 01 TJ 01 0 2 3 a aq ? n 3 I 3 3 <n o in o w w 2. u 11 a. H o. i= s*, a ~ 3 3 ~ 31 in " s. 2 O O *"* 3 " .* in i rat* W *" in -- rt 01 = a. < " & H ftt O<'S*' ? 5r Oft 01 fi *< 5 3 5 <------a- 3 3 ** ^ ' cr a ^ a O Sn' ri-sj n i 3* S T3 c. C *3 : 2 (9 ra "> 3 1 r4r *a o n n a u o ra O * ft S n" Sa$ y <9 n n a 1 3pi 5ft 3 -O Ji o a ^ >A < S ^ ti * ** 9J < S an 3 * a sr 3 a. n M < 3 n* n a PI 3 sO^ A. o Si o 3 a. 2 ra "* n **<* 3 INi- -3-3 w C. 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(9 I to e* 3* A B> - SB " S- ^ to i a 5 S' A A tS 2 to a 3* A ; CD o c : 2 I 3 c* < a o--* oa* 3 a. < ! a a ,, a, 3 2 JT i A* O T n (* (A 3 a 2 s; o* A : -< TO 31 ta &. A P*; 0 c to 33 A to 3 * l i P# C cr M- to o o '** A GJ a* cn A A 3 3 pa ,: -----C-U- < e o A 3 O 3 PB f 3U* SoT:; r 3 3 ST A O' 3 0 3 3 i S o* r** A A ' NO *s TO c 3 A C P O: o 3 3 a. a. 3 ccl a. 3 ST LT> TT SO z'" asbestos fib e rs . The gross and m ic ro s c o p ic appearances of the lesions are illu stra te d . ' tlije com bined a ctio n o( the h y g ro s c o p ic and a lk a lin e ce m e n t and the Ir r ita tin g Mellon Institute, Pittsburqh, Px. S ~ ar O o' <3 * n 3 # *T o* 3* a o' i-- 3 S ST Mc Z. P P 3 (A 00 3 3 Hig O P> 00 (A a (A y Q. O o* do * o -- o < A a. n CA P P-. (A . a 3C 3 <9 0 o P 3* Q* 3O* <# 1 . r* a. y 3 -- 5*; u aa -- P r*-* 1 3 3 p g* ? -- 3" 3 -- o 0 ? 3i w -- cr v; u O p o 2 * ^ p* fp 3* 3C a* 7. ^ (0 3 _3 TP 3 3 3* O33 o a. co >-3 o s o t* > ut a* rc u2. P o u * V i *1 3 3 a. 3a * ' m a. n 3 3 0 <* (A . . CA 3 $ 0 p"1r n 1 u 3 o00o_ .aMo,To S' 00 'O' vn,; 3mm l*' P j o t IT 0 ST o ' a <a di!5 lr s1e 3;r A3 <-S re ~ - Ut ; N< Cond. fro m B u ll. Hyg. / / c A MJCCXOSf INSTITUTE, PTXTSBTJRaH, Px. J>* -9k S'v * Crt s 3 n P> 5> -* a o in i! [ s U\; oSI X18 o era 3 *< 3 ma 3* 3ra* 0 i tra u ra 3 n to 3C. a su t a v J i 3 Xr n c C it 3 na v:* 5 ^ !B j rr r Mellon- Institute. Potsbukoh, Pa. "rt *p* m* t ^ cu -- ai =^=^= ! r rt c* fc-p 3 3 a. rt i p 3** Jc3 3 u - I! " . oH n (A 3* a 3* rt c rt P v< rt a> o o' w rt II *< o (A i U) N 0 rt 0* rt 0 CL L. S A 3* n1 0r* ' nC/>= 5 3* oP P m* rt rt (o* >t rt 3 P w 5'g. S'T * rt 3 a rt !" UI X CO o W o C 0p0 W < n 3 3* ra-p P rt rt rt S rt -- C_. 3 c 3 (0 3" * -5 r3t" C/1 "C. i rt a 0 o rt sr sr rt (0 (A (A rt- O c u I 5 33 rt JO' P n ru~ w> p rt 2 Oq (a c/i P C3 9* 3* ,, -- - . 3 "t p < P P 2 5 *0 f5 -- < rt 3 P 5 * * "0^0 C ' n v* o rt CA 5 n 5 P 5 n* < " 0. O' p 3 3 3 ",ac5ssS P p P P rntN - -_3'52 o rt 3 0) 3 ---*2.O0 BQ qS' '/-. c 3_* (A -Tt 1 "C n^ 3 S; ;2 _ o' 3 o; r? 3W s*2 3 TM-N-- 2 05 ' OQ rt s> M f M-2 " cr`t O= 91 ,2:*u 3* o2^ 3 cui c li 3 3- ? JJ* rt Si .P 3 ? oo H* n P a. o X Sfo^sg o* _AP* * TJ w s rt p ^p* -- 2 ^2? 2- (A s rt ? 3 3rt3-2OsO *p qi (A a* ? S" 2 3 3Hi ra u Pf ?* s 2 * 2* J . 3 r o' a- ? 2 " -2 2 " u S> s' 2*1 - <j 3* 2CL ^ 33 p I - 2: p 3 a g rt % "U n 5L _ <-* ! 3 I ? Ho C*C>"n9 r ri*3n 3- 3? pp ?o. H n o*o 2 : 2.*< v 3 n rt p ?3 1 -- P O x a rt i o 3 rt z -- CX!r 3 > ' / FORM 77 r 9 ;; z m \i a S^ 2c Sj3 V a <* a z r r 33 ^ Mellon irn i \ cnoti. Pa. |3 ? ? 3 v *-- ? e O n a o w -* 2- a -> 5 T r- -- ^ Ev a - 3 a "aTM* ^ (g a> o>t Qep <tn-r <v0.' c c * 5) p e: a m aA p- o. 3 ? " O* a . *t A 3 3a o ,, A* a (ft ~ <:19 CL A 3 3 O 2 OM jj --SJ* A A 3 2 5 it. *3 i VJ1 O vO m Oi N , a 3 < A - U -x 2as. 3 .2>i. B 0 a 3 n 0A a AV VI M9> an A a * SL i- O *\J^1zr m B a sr A CL A OP IN A a . a I a O; II 2 1 5 3 "w--H*. --A^ ^o-So n ,,o E 0 ;r a* s S 22. 33 - CP 3 J2 * 3* 2. c tC? 9<>s i-- JV a *2<3 -j CP " on c4 C3 53 c n3 w-- O 01 cs 03 r/i <5 -<731 ci 0 c<nn 01 C%*" r3 3f-- C O C3 2 pm Co3 MO o 0) O SQ A .*1 r-, a *1 s* O ~ 1 O 0o aa ~ v0o? 3r 3g C3 < 0 = 03 5 O A 2 Sr a. ro vO . vn % 3 r ro 3 " a s OP "jf a a C <OP; a* o3p A 03 *< a a \ )" *0*M TT |ir p> t# o* n u o n n s* (a 3 QQ a (A 3 n X u (fl 3 Q 3 3 0 3 fW* 3 o pmm (0 (9 4 o ffl .a o' <5* 3* rt O 3 O a r3* 1 3 o' 3 0 O 3 w cr 0 u> 1 I tos dust. The appearance of such changes seem s to be re la te d to the breakdow n of asbestosis bodies w hich m ay lib e ra te some fib ro g e n lc agent. - - Authors* sum m ary / ron* jy "f ( r \ MaLtON IyaTmiTB, PmsscRon. Pa. 55 3 3 5 XA O(a Acr x * i A o AW* gf 52. w rf 3 >? s A w n w x. 3 3 is CA q O MO -n O v 3 Si > s0* s 3 -0 1 O 0 o > A! 01 <r w S) 0 o' 'J' o*; A 3 CO 0 TM TO W o i A n 2 < ** A. 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