Document rjLk1NDkemd864zyavD8yde

W *....... ................................................................................................................................................................................... 4A9LZ6 _ 403 AlUa -sz> DuPont-5990 TRADE SECRET Study Title H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 3 of 5 Laboratory Project ID: DuPont-5990 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) AUTHOR: Susan A. MacKenzie, V.M.D., Ph.D., D.A.B.T. Study Completed on: January 18,2002 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Page 612 of 1408 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX G INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS -613Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS BASELINE FORELIMB GRIP STRENGTH (kg! HINDLIMB GRIP STRENGTH (ke) Animal Number Mean of Mean of Trial 1 Trial 2 Trial 3_____ Trials________ Trial 1 Trial 2 Trial 3 Trials Group I: 0 mg/kg/day 646371 0.47 0.55 0.44 646398 0.48 0.37 0.41 646411 0.50 0.50 0.72 646416 0.54 0.42 0.59 646432 0.63 0.69 0.68 646446 0.47 0.60 0.51 646459 0.76 0.56 0.31 646460 0.63 0.54 0.47 646487 0.25 0.36 0.47 646494 0.59 0.61 0.66 0.49 0.42 0.57 0.52 0.67 0.53 0.54 0.55 0.36 0.62 0.40 0.41 0.33 0.38 0.22 0.32 0.23 0.26 0.37 0.41 0.31 -0.36 0.39 0.24 0.41 0.35 0.42 0.37 0.30 0.36 0.25 0.29 0.25 0.26 0.29 0.33 0.32 0.31 0.52 0.41 0.36 0.43 0.36 0.30 0.38 0.35 0.26 0.22 0.26 0.25 Group III: 25 mg/kg/day 646370 0.64 0.49 0.57 646399 0.59 0.46 0.51 646414 0.48 0.76 0.55 646421 0.65 0.55 0.87 646423 0.29 0.53 0.58 646426 0.56 0.53 0.40 646443 0.57 0.66 0.57 646454 0.53 0.49 0.42 646458 0.47 0.56 0.62 646471 0.50 0.52 0.50 0.57 0.52 0.60 0.69 0.47 0.50 0.60 0.48 0.55 0.51 0.26 0.34 0.53 0.36 0.31 0.29 0.36 0.38 0.38 0.32 0.42 0.42 0.30 0.22 0.31 0.22 0.28 0.24 0.39 0.39 0.29 0.31 0.36 0.37 0.35 0.30 0.33 0.28 0.20 0.32 0.38 0.32 0.37 0.39 0.28 0.25 0.36 0.35 0.33 0.27 Group V: 100 mg/kg/day 646349 0.35 0.38 0.51 646373 0.52 0.61 0.50 646385 0.56 0.51 0.37 646435 0.48 0.60 0.70 646455 0.62 0.61 0.61 646456 0.51 0.65 0.48 646463 0.28 0.35 0.28 646469 0.42 0.56 0.57 646472 0.53 0.65 0.60 646488 0.60 0.52 0.62 0.41 0.54 0.48 0.59 0.61 0.55 0.30 0.52 0.59 0.58 0.32 0.27 0.29 0.23 0.21 0.27 0.33 0.30 0.32 0.41 0.34 0.22 0.32 0.47 0.31 0.31 0.41 0.25 0.18 0.17 0.22 0.44 0.36 0.32 0.30 0.30 0.26 0.25 0.30 0.34 0.29 0.24 0.32 0.32 0.37 0.32 0.19 0.37 0.29 0.30 - 614Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS BASELINE FORELIMB GRIP STRENGTH (kg) HINDLIMB GRIP STRENGTH fket Animal Number Trial 1 Trial 2 Trial 3 Mean of Trials Mean of Trial 1 Trial 2 Trial 3 Trials Group VII: 500 mg/kg/day 646337 0.32 0.35 0.62 646364 0.64 0.63 0.56 646369 0.58 0.63 0.46 646372 0.76 0.75 0.51 646384 0.42 0.61 0.64 646397 0.61 0.53 0.58 646428 0.54 0.55 0.56 646448 0.58 0.66 0.54 646474 0.32 0.41 0.44 646484 0.24 0.38 0.65 0.43 0.61 0.56 0.67 0.56 0.57 0.55 0.59 0.39 0.42 0.21 0.41 0.22 0.25 0.30 0.32 0.38 0.46 0.36 0.27 0.37 0.37 0.24 0.35 0.28 0.41 0.36 0.32 0.30 0.27 0.23 0.26 0.26 0.29 0.27 0.33 0.34 0.34 0.33 0.30 0.28 0.29 0.40 0.34 0.29 0.36 0.27 0.27 0.31 0.32 -615Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS WEEK 13 FORELIMB GRIP STRENGTH (kg) HINDLIMB GRIP STRENGTH (kg') Animal Number Trial 1 Trial 2 Trial 3 Mean of Trials Mean of Trial 1 Trial 2 Trial 3 Trials Group I: 0 mg/kg/day 646371 1.63 1.67 1.74 646398 1.06 1.16 1.11 646411 2.03 2.29 2.03 646416 1.36 1.26 1.46 646432 1.50 1.23 1.20 646446 1.33 1.41 1.39 646459 1.60 1.03 1.48 646460 1.87 1.78 1.96 646487 1.43 1.90 1.34 646494 1.58 1.49 1.46 1.68 1.11 2.12 1.36 1.31 1.38 1.37 1.87 1.56 1.51 0.75 0.93 0.79 0.73 0.83 0.78 0.63 0.81 1.25 0.58 0.63 0.75 0.86 0.85 0.89 0.83 0.68 0.76 0.79 0.98 0.81 0.82 1.09 1.09 0.88 1.03 0.94 0.90 1.02 0.81 0.82 0.78 0.90 0.65 0.87 0.76 0.86 1.00 0.95 0.91 Group III: 25 mg/kg/day 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 1.87 1.73 1.41 1.64 1.25 1.49 1.07 1.56 1.36 1.14 1.16 1.43 2.06 0.95 1.41 1.34 0.92 1.23 1.20 0.82 Group V: 100 mg/kg/day 1.35 1.99 1.70 1.30 1.78 1.20 1.38 1.27 0.98 0.97 1.46 1.72 1.72 1.30 1.48 1.34 1.12 1.35 1.18 0.98 0.53 0.72 0.81 0.51 0.63 0.81 0.76 0.66 0.64 0.51 0.54 0.70 0.84 0.75 0.78 0.73 0.68 0.74 0.88 0.70 0.87 0.71 0.87 0.65 0.99 1.07 0.85 0.55 0.80 0.96 0.69 0.65 0.69 0.58 0.79 0.72 0.82 0.74 0.97 0.77 646349 1.23 1.72 1.43 646373 1.53 1.75 1.30 646385 1.49 1.04 1.42 646435 1.18 1.89 0.77 646455 1.44 1.08 0.70 646456 1.68 1.88 1.82 646463 1.01 1.13 1.31 646469 1.83 1.58 1.70 646472 1.25 0.83 0.97 646488 0.87 0.81 1.24 1.46 1.53 1.32 1.28 1.07 1.79 1.15 1.70 1.02 0.97 0.54 0.37 0.52 0.84 0.87 0.88 0.53 1.00 0.80 0.92 0.92 0.82 0.69 0.76 0.60 0.81 0.92 1.04 0.51 0.66 0.61 0.81 0.86 0.86 0.52 0.57 0.67 0.76 0.86 0.81 0.48 0.86 0.78 0.89 0.68 0.92 0.59 0.84 0.59 0.81 -616Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS WEEK 13 FORELIMB GRIP STRENGTH (kg) HINDLIMB GRIP STRENGTH (ks) Animal Number Trial 1 Trial 2 Trial 3 Mean of Trials Mean of Trial 1 Trial 2 Trial 3 Trials Group VII: 500 mg/kg/day 646337 0.71 1.40 1.45 646364 1.35 1.35 0.90 646369 0.38 0.35 0.47 646372 0.72 1.38 1.52 646384 1.55 1.00 0.87 646397 0.90 1.57 1.67 646428 1.65 2.07 1.40 646448 1.26 1.05 0.96 646474 0.97 0.90 1.28 646484 1.29 1.14 0.96 1.19 1.20 0.40 1.21 1.14 1.38 1.71 1.09 1.05 1.13 0.61 0.66 0.61 0.49 0.55 0.74 0.56 0.58 0.54 0.72 0.72 0.70 0.81 0.71 0.54 0.91 1.09 0.90 0.63 0.51 0.50 0.78 0.77 0.64 0.56 0.76 0.78 0.88 0.82 0.89 0.63 0.59 0.56 0.71 0.69 0.97 0.55 0.73 0.70 0.86 -617Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS RECOVERY FORELIMB GRIP STRENGTH (kg) HINDLIMB GRIP STRENGTH fleet Animal Number Trial 1 Trial 2 Trial 3 Mean of Mean of Trials______ Trial 1 Trial 2 Trial 3 Trials Group I: 0 mg/kg/day 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 0.86 1.70 2.30 1.28 1.79 1.17 1.04 1.97 1.51 1.71 0.89 1.40 2.15 1.21 1.46 1.58 1.56 1.58 1.41 1.06 Group VII: 500 mg/kg/day 1.26 1.27 2.21 1.25 1.00 1.40 1.16 1.54 0.74 1.14 1.00 1.46 2.22 1.25 1.42 1.38 1.25 1.70 1.22 1.30 0.61 0.85 0.64 0.69 0.67 0.88 1.06 1.30 0.98 0.74 0.98 0.80 0.82 0.56 0.71 0.67 0.68 0.65 0.78 0.76 0.92 1.07 0.86 0.90 0.87 0.87 0.81 0.83 0.75 0.84 0.70 0.75 1.11 0.84 0.70 0.67 0.82 0.94 0.85 0.81 646337 1.42 1.58 1.62 646364 1.29 1.13 0.98 646369 0.51 0.49 0.41 646372 1.81 1.68 1.68 646384 1.14 1.09 1.39 646397 1.89 1.67 1.65 646428 1.55 1.38 1.07 646448 1.28 1.51 1.34 646474 0.66 1.14 0.94 646484 1.26 1.89 1.04 1.54 1.13 0.47 1.72 1.21 1.74 1.33 1.38 0.91 1.40 0.50 0.61 0.61 0.87 0.65 0.56 0.58 0.83 0.84 0.64 0.84 0.84 0.66 0.56 0.85 0.52 0.73 0.69 0.81 0.57 0.66 0.78 1.00 0.99 0.53 0.66 0.72 0.61 0.72 0.52 0.57 0.69 0.75 0.77 0.69 0.65 0.68 0.92 0.64 0.62 -618 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS BASELINE FORELIMB GRIP STRENGTH (kel HINDLIMB GRIP STRENGTH fkgl Animal Number Trial 1 Trial 2 Trial 3 Mean of Trials Mean of Trial 1 Trial 2 Trial 3 Trials Group II: 0 mg/kg/day 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 0.47 0.47 0.58 0.28 0.59 0.25 0.35 0.46 0.52 0.47 0.76 0.67 0.72 0.53 0.42 0.34 0.45 0.58 0.51 0.37 Group IV: 25 mg/kg/day 0.76 0.57 0.67 0.68 0.43 0.41 0.45 0.73 0.59 0.41 0.66 0.57 0.66 0.50 0.48 0.33 0.42 0.59 0.54 0.42 0.33 0.34 0.51 0.36 0.35 0.36 0.42 0.42 0.33 0.32 0.46 0.45 0.30 0.38 0.31 0.26 0.24 0.25 0.23 0.24 0.23 0.34 0.20 0.31 0.26 0.50 0.26 0.32 0.25 0.29 0.39 0.36 0.39 0.41 0.33 0.25 0.23 0.28 0.34 0.29 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 0.52 0.24 0.50 0.58 0.48 0.46 0.49 0.25 0.58 0.67 0.58 0.47 0.64 0.60 0.56 0.59 0.68 0.60 0.45 0.69 Group VI: 100 mg/kg/day 0.62 0.33 0.67 0.64 0.36 0.68 0.80 0.34 0.43 0.76 0.57 0.35 0.60 0.61 0.47 0.58 0.66 0.40 0.49 0.71 0.24 0.27 0.31 0.32 0.31 0.48 0.32 0.33 0.27 0.31 0.22 0.28 0.31 0.38 0.24 0.41 0.31 0.37 0.22 0.34 0.28 0.38 0.32 0.31 0.27 0.34 0.31 0.54 0.50 0.50 0.27 0.37 0.31 0.27 0.31 0.36 0.28 0.34 0.31 0.51 646501 0.56 0.58 0.58 646505 0.54 0.64 0.81 646510 0.44 0.53 0.46 646534 0.50 0.82 0.85 646556 0.56 0.55 0.53 646578 0.57 0.52 0.54 646608 0.47 0.54 0.61 646624 0.39 0.54 0.38 646629 0.61 0.40 0.64 646633 0.55 0.62 0.58 0.57 0.66 0.48 0.72 0.55 0.54 0.54 0.44 0.55 0.58 0.32 0.39 0.32 0.47 0.50 0.28 0.31 0.35 0.36 0.35 0.41 0.34 0.38 0.37 0.38 0.20 0.33 0.21 0.33 0.20 0.27 0.22 0.20 0.32 0.21 0.35 0.21 0.37 0.25 0.31 0.34 0.42 0.34 0.37 0.38 0.25 0.27 0.25 0.26 0.31 -619Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS BASELINE FORELIMB GRIP STRENGTH (kg) HINDLIMB GRIP STRENGTH fieri Animal Number Trial 1 Trial 2 Trial 3 Mean of Mean of Trials________ Trial 1 Trial 2 Trial 3 Trials Group VIII: 500 mg/kg/day 646506 0.69 0.69 0.47 646508 0.51 0.67 0.57 646540 0.32 0.46 0.51 646542 0.30 0.67 0.47 646545 0.47 0.55 0.59 646548 0.66 0.68 0.50 646599 0.39 0.52 0.51 646618 0.37 0.39 0.63 646637 0.54 0.42 0.66 646650 0.69 0.50 0.36 0.62 0.58 0.43 0.48 0.54 0.61 0.47 0.46 0.54 0.52 0.31 0.39 0.23 0.38 0.33 0.45 0.43 0.30 0.28 0.24 0.31 0.24 0.43 0.31 0.37 0.44 0.48 0.38 0.31 0.25 0.20 0.28 0.31 0.34 0.44 0.24 0.34 0.28 0.34 0.36 0.31 0.39 0.34 0.26 0.37 0.43 0.25 0.31 0.34 0.33 -620Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS WEEK 13 FORELIMB GRIP STRENGTH (kg) HINDLIMB GRIP STRENGTH (kg) Animal Number Trial 1 Trial 2 Trial 3 Mean of Trials Mean of Trial 1 Trial 2 Trial 3 Trials Group II: 0 mg/kg/day 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 1.09 1.33 0.77 0.87 0.77 0.81 1.42 0.77 1.06 1.16 0.63 1.33 0.81 1.36 0.41 0.87 0.82 1.05 0.60 1.25 Group IV: 25 mg/kg/day 1.02 0.82 1.27 0.80 0.78 1.25 0.72 1.48 0.69 1.25 0.91 1.16 0.95 1.01 0.65 0.98 0.99 1.10 0.78 1.22 0.67 0.72 0.66 0.87 0.72 0.73 0.90 0.87 0.95 0.88 0.76 0.77 0.40 0.48 0.39 0.51 0.47 0.53 0.58 0.77 0.64 0.73 0.69 0.65 0.60 0.68 0.69 0.66 0.69 0.67 0.68 0.77 0.91 0.80 0.42 0.50 0.66 0.69 0.66 0.67 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 0.79 1.31 0.86 0.99 1.26 0.54 1.48 0.85 0.81 1.38 0.90 0.91 0.90 1.26 0.67 1.10 1.25 0.84 0.77 1.13 Group VI: 100 mg/kg/day 0.95 0.86 0.80 1.06 0.65 1.01 0.97 1.05 0.66 0.95 0.88 1.03 0.85 1.10 0.86 0.88 1.23 0.91 0.75 1.15 0.74 0.56 0.69 0.61 0.61 0.61 0.63 0.58 0.52 0.70 0.71 0.69 0.59 0.66 0.49 0.64 0.73 0.69 0.69 0.79 0.64 0.49 0.47 0.44 0.59 0.63 0.64 0.66 0.62 0.61 0.66 0.61 0.58 0.70 0.58 0.69 0.71 0.47 0.62 0.63 646501 1.40 1.34 1.45 646505 1.05 1.51 1.02 646510 1.12 0.98 0.90 646534 1.43 1.36 1.28 646556 1.63 1.34 1.44 646578 1.16 0.93 1.15 646608 1.10 1.40 1.20 646624 0.79 0.76 0.42 646629 1.34 1.13 1.05 646633 1.09 1.26 0.68 1.40 1.19 1.00 1.36 1.47 1.08 1.23 0.66 1.17 1.01 0.71 0.84 0.84 0.77 0.80 0.71 0.49 0.63 0.68 0.84 0.82 0.77 0.51 0.63 0.59 0.42 0.41 0.54 0.48 0.61 0.56 0.59 0.73 0.67 0.48 0.53 0.57 0.54 0.50 0.47 0.80 0.76 0.60 0.81 0.58 0.46 0.55 0.66 0.53 0.50 -621 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS WEEK 13 FORELIMB GRIP STRENGTH ike) HINDLIMB GRIP STRENGTH fkel Animal Number Trial 1 Trial 2 Trial 3 Mean of Trials Mean of Trial 1 Trial 2 Trial 3 Trials Group VIII: 500 mg/kg/day 646506 1.12 1.17 0.72 646508 1.05 0.93 1.01 646540 0.63 0.68 0.52 646542 0.65 0.54 0.69 646545 1.32 1.28 1.32 646548 1.01 0.87 1.25 646599 1.31 1.20 0.85 646618 0.64 0.73 0.86 646637 1.21 1.36 1.02 646650 1.00 1.01 1.07 1.00 1.00 0.61 0.63 1.31 1.04 1.12 0.74 1.20 1.03 0.43 0.52 0.48 0.61 0.71 0.63 0.50 0.61 0.59 0.61 0.64 0.49 0.66 0.81 0.77 0.51 0.58 0.60 0.52 0.47 0.58 0.60 0.55 0.61 0.76 0.94 0.73 0.61 0.66 0.65 0.48 0.65 0.57 0.58 0.75 0.56 0.52 0.59 0.81 0.64 -622Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS RECOVERY FORELIMB GRIP STRENGTH (kg) HINDLIMB GRIP STRENGTH (kg) Animal Number Mean of Trial 1 Trial 2 Trial 3 Trials Mean of Trial 1 Trial 2 Trial 3 Trials Group II: 0 mg/kg/day 646511 1.11 1.29 1.55 1.32 646549 0.68 0.83 1.06 0.86 646551 1.68 1.16 1.61 1.48 646565 0.97 1.08 0.84 0.96 646580 0.46 0.71 0.46 0.54 646581 1.00 0.71 1.05 0.92 646586 0.66 0.90 1.19 0.92 646613 1.09 1.35 1.12 1.19 646627 0.45 0.63 0.90 0.66 646652 1.61 1.64 1.29 1.51 0.79 0.81 0.77 0.79 0.85 0.64 0.61 0.70 0.87 0.88 1.01 0.92 0.67 0.72 0.66 0.68 0.64 0.68 0.66 0.66 0.67 0.63 0.65 0.65 0.61 0.66 0.56 0.61 0.77 0.51 0.71 0.66 0.61 0.76 0.65 0.67 0.74 0.72 0.77 0.74 Group VIII: 500 mg/kg/day 646506 1.02 0.61 0.55 646508 0.85 0.97 1.13 646540a 0.38 0.32 0.35 646542 0.81 0.81 0.76 646545 1.12 1.04 0.80 646548 1.07 1.34 1.37 646599 0.60 0.82 0.89 646618 0.76 0.79 0.62 646637 0.99 0.79 0.85 646650 1.46 1.21 1.10 0.73 0.98 0.35 0.79 0.99 1.26 0.77 0.72 0.88 1.26 0.43 0.52 0.54 0.59 0.79 0.81 0.59 0.58 0.69 0.74 0.64 0.60 0.78 0.79 0.77 0.58 0.71 0.52 0.51 0.50 0.47 0.46 0.54 0.30 0.69 0.70 0.66 0.66 0.76 0.73 0.50 0.73 0.62 0.66 0.78 0.60 0.49 0.43 0.68 0.72 aRat 646540 was uncooperative during forelimb grip strength. Data were not included in the group mean or the statistical evaluation. -623Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX H INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS -624Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS EXPLANATORY NOTES INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY SCORING SYSTEM MANIPULATIONS IN OPEN FIELD ARENA (FREE ROAMING SPACE) APPROACH & TOUCH: AUDITORY STIMULUS: TAIL PINCH: -1 -- no reaction 0 = normal 1 = increased reaction (jumps away or attacks) -1 0= 1= no reaction normal reaction (rat flinches or flicks ear) exaggerated reaction (rat jumps, flips) -1 = 0= 1= no response normal (turns toward site) exaggerated response (vocalizations, rapid turning) IN MOTOR ACTIVITY MONITOR PUPILLARY RESPONSE: DEFECATION: URINATION: Abbreviation: No Data Collected 0 _ present 1 = absent 0 -- absent 1 = present D = diarrhea 0 = absent 1 = present -625 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS Group I: 0 mg/kg/day___________________________________________________________ ________________________________Manipulation___________________ In Motor Activity Animal Number Time Point Approach Auditory Pupillary and Touch Stimulus Tail Pinch Response Defecation Urination 646371 Baseline 0 0 0 0 Week 13 0 0 0 0 Recovery 0 0 0 0 10 11 11 646398 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 646411 Baseline 0 000 0 0 Week 13 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 646416 Baseline 0 0 0 0 11 Week 13 0 0 0 0 0 0 Recovery 0 0 0 0 0 1 646432 Baseline 0 000 0 0 Week 13 0 0 0 0 11 Recovery 0 0 0 0 0 1 646446 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 11 Recovery 0 0 0 0 0 1 646459 Baseline 0 0 0 0 10 Week 13 0 0 0 0 0 1 Recovery 0 0 0 0 0 1 646460 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 11 Recovery 0 0 0 0 11 646487 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 11 Recovery 0 0 0 0 11 646494 Baseline Week 13 Recovery 0 0 0 000 000 000 00 11 11 -626Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS Group III: 25 mg/kg/day________________________________________________________ ______________________________ Manipulation___________________ In Motor Activity Animal Number Time Point Approach Auditory Pupillary and Touch Stimulus Tail Pinch Response Defecation Urination 646370 Baseline 0 0 0 0 1 1 Week 13 0 0 1 0 0 1 646399 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 1 1 646414 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 0 1 646421 Baseline 0 0 0 0 1 1 Week 13 0 0 1 0 0 1 646423 Baseline 0 0 0 0 0 0 Week 13 0 -1 0 0 1 1 646426 Baseline a 0 0 0 0 Week 13 0 0 0 0 0 0 646443 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 1 1 646454 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 1 1 646458 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 1 1 646471 Baseline 0 0 0 0 1 1 Week 13 0 0 1 0 0 1 a Defecation and urination were not recorded. -627Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS Group V: 100 mg/kg/day________________________________________________________ ________________________________Manipulation___________________ In Motor Activity Animal Number Time Point Approach Auditory Pupillary and Touch Stimulus Tail Pinch Response Defecation Urination 646349 Baseline 0 0 0 0 0 0 Week 13 0 0 0 0 0 1 646373 Baseline 0 0 0 0 0 1 Week 13 a 0 0 0 0 1 1 646385 Baseline 0 0 10 0 1 Week 13 0 0 10 1 1 646435 Baseline 0 0 0 0 1 1 Week 13 b 0 0 0 0 1 1 646455 Baseline 0 0 0 0 0 1 Week 13 b 0 000 0 0 646456 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 1 1 646463 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 1 1 646469 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 0 1 646472 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 0 1 646488 Baseline 0 0 0 0 0 0 Week 13 0 0 0 0 1 1 a Abnormal gait, flattened rear posture. b Sore forelimb toes. - 628 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS Group VII: 500 mg/kg/day______________________________________________________ _______________________________ Manipulation__________________ In Motor Activity Animal Number Time Point Approach Auditory Pupillary and Touch Stimulus Tail Pinch Response Defecation Urination 646337 Baseline 0 0 0 0 0 1 Week 13 a 0 -1 0 0 1 1 Recovery 0 0 0 0 1 1 646364 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 646369 Baseline 0 0 0 0 1 1 Week 13 a'b 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 646372 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 0 1 Recovery 0 0 0 0 1 1 646384 Baseline 0 0 0 0 1 1 Week 13 c 0 0 0 0 0 1 Recovery 0 0 0 0 0 1 646397 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 646428 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 11 Recovery 0 0 0 0 0 1 646448 Baseline 0 0 0 0 0 1 Week 13 00 10 11 Recovery 0 0 0 0 11 646474 Baseline 00 0 0 11 Week 13 a 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 646484 Baseline 0 0 0 0 0 1 Week 13 a 0 0 0 0 11 Recovery 0 0 0 0 11 a Stained perineum, yellow. b Sore forelimb toes. c Sore left forelimb. -629Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS Group II: 0 mg/kg/day__________________________________________________________ ________________________________Manipulation___________________ In Motor Activity Animal Number Time Point Approach Auditory Pupillary and Touch Stimulus Tail Pinch Response Defecation Urination 646511 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 0 1 Recovery 0 0 0 0 0 1 646549 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 0 0 Recovery 0 0 0 0 1 1 646551 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 0 1 Recovery 0 0 0 0 1 1 646565 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 0 0 Recovery 0 0 0 0 1 1 646580 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 0 1 Recovery 0 0 0 0 1 1 646581 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 646586 Baseline 0 0 0 0 0 0 Week 13 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 646613 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 0 1 Recovery 0 00 0 0 1 646627 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 1 1 Recovery 0 00 0 0 1 646652 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 0 1 Recovery 0 0 0 0 0 1 -630Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS Group IV: 25 mg/kg/day________________________________________________________ ________________________________ Manipulation___________________ In Motor Activity Animal Number Time Point Approach Auditory Pupillary and Touch Stimulus Tail Pinch Response Defecation Urination 646502 Baseline 0 0 0 0 0 0 Week 13 0 0 0 0 0 1 646522 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 1 1 646567 Baseline 0 0 0 0 1 0 Week 13 0 0 0 0 0 1 646576 Baseline 0 0 0 0 0 0 Week 13 0 0 0 0 1 1 646595 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 0 1 646621 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 1 1 646635 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 0 1 646660 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 1 1 646664 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 1 1 646673 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 1 1 -631 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS Group VI: 100 mg/kg/day_______________________________________________________ ______________________________ Manipulation___________________ In Motor Activity Animal Number Time Point Approach Auditory Pupillary and Touch Stimulus Tail Pinch Response Defecation Urination 646501 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 1 1 646505 Baseline 0 0 0 0 Week 13 0 0 0 0 10 11 646510 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 1 1 646534 Baseline 0 0 0 0 0 1 Week 13 0 0 0 0 0 0 646556 Baseline 0 0 0 0 1 1 Week 13 0 0 00 0 1 646578 Baseline 0 0 00 0 1 Week 13 0 0 0 0 1 1 646608 Baseline 0 0 0 0 0 0 Week 13 0 0 0 0 1 1 646624 Baseline 00 00 0 1 Week 13 0 0 0 0 1 1 646629 Baseline 0 0 0 0 0 Week 13 0 0 00 0 1 1 646633 Baseline 0 0 0 0 0 Week 13 0 0 0 0 l 1 1 -632Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS Group VIII: 500 mg/kg/day______________________________________________________ ________________________________Manipulation___________________ In Motor Activity Animal Number Time Point Approach Auditory Pupillary and Touch Stimulus Tail Pinch Response Defecation Urination 646506 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 646508 Baseline 0 0 0 0 0 0 Week 13 a 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 646540 Baseline 0 0 0 0 1 1 Week 13 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 646542 Baseline 0 0 10 0 0 Week 13 a 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 646545 Baseline 0 0 0 0 0 1 Week 13 a 0 0 0 0 0 1 Recovery 0 0 0 0 0 1 646548 Baseline 0 0 0 0 11 Week 13 0 0 0 0 0 1 Recovery 0 0 0 0 11 646599 Baseline 0 000 0 0 Week 13 0 0 0 0 0 1 Recovery 0 0 0 0 0 1 646618 Baseline 0 00 0 0 1 Week 13 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 646637 Baseline 0 00 0 0 1 Week 13 a 0 0 0 0 1 1 Recovery 0 00 0 0 1 646650 Baseline 0 0 0 0 0 1 Week 13 a 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 Stained perineum, yellow. - 633 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX I INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT -634Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS Animal Number BASELINE SUCCESSIVE 10-MINUTE INTERVALS I 2 3 4 5 6 Total Group I: 0 mg/kg/day 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 377 257 250 41 19 0 944 ' 332 268 220 181 58 25 1084 385 395 288 1 0 0 1069 392 323 332 288 268 222 1825 366 289 93 22 5 5 780 358 200 147 20 8 9 742 364 281 181 215 9 2 1052 327 216 166 204 32 0 945 348 173 173 98 2 9 803 406 300 261 8 18 8 1001 Group III: 25 mg/kg/day 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 327 269 236 149 124 271 290 181 45 0 426 378 249 43 14 327 239 131 69 346 236 128 4 6 365 246 105 42 27 440 349 232 268 192 419 270 232 170 179 360 289 254 88 4 379 253 73 34 18 0 1105 62 849 14 1124 14 726 4 724 5 790 27 1508 51 1321 1 996 15 772 Group V: 100 mg/kg/day 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 377 411 266 245 76 241 172 154 136 85 340 214 122 7 8 372 227 130 12 7 244 236 188 71 12 412 359 44 6 46 412 339 344 253 173 393 280 274 15 22 387 152 0 1 4 363 181 117 49 16 1 1376 9 797 2 693 3 751 14 765 25 892 3 1524 1 985 11 555 1 727 -635 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS Animal Number BASELINE Successive 10-Minute Intervals I 2 3 4 5 6 Total Group VII: 500 mg/kg/day 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 438 344 284 109 17 406 328 269 175 80 344 318 234 169 9 335 282 26 28 10 362 234 211 150 200 409 355 359 158 119 316 162 84 0 6 398 240 16 17 14 362 249 218 33 9 355 174 30 16 17 9 1201 2 1260 0 1074 26 707 3 1160 43 1443 2 570 5 690 17 888 8 600 -636Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS Animal Number WEEK 13 Successive 10-Minute Intervals I 2 3 4 5 6 Total Group I: 0 mg/kg/day 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 412 308 277 259 230 117 1603 352 312 233 149 154 166 1366 425 388 333 347 314 241 2048 410 300 279 278 238 250 1755 385 331 299 339 334 265 1953 472 406 310 296 154 90 1728 408 306 253 270 314 53 1604 335 86 31 152 6 19 629 352 221 158 166 171 146 1214 496 437 356 341 295 306 2231 Group III: 25 mg/kg/day 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 369 271 256 145 182 24 1247 343 247 305 177 203 135 1410 430 377 334 103 249 214 1707 340 203 199 131 126 139 1138 297 235 293 235 222 154 1436 440 324 348 328 301 278 2019 421 365 327 300 223 330 1966 410 358 371 210 325 220 1894 381 353 283 291 322 142 1772 418 252 209 225 201 298 1603 Group V: 100 mg/kg/day 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 420 336 357 256 272 160 1801 346 258 165 171 258 148 1346 412 342 221 1 1 112 1089 389 283 218 169 236 224 1519 340 198 238 260 178 195 1409 454 384 329 221 262 206 1856 361 310 217 284 155 129 1456 418 273 235 197 248 154 1525 500 417 362 323 259 216 2077 455 422 381 334 326 332 2250 -637 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS Animal Number WEEK 13 Successive 10-Minute Intervals I 2 3 4 5 6 Total Group VII: 500 mg/kg/day 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 429 318 320 232 236 174 1709 465 372 279 293 270 342 2021 346 316 261 212 274 267 1676 381 348 262 228 280 240 1739 362 296 244 220 298 178 1598 494 399 365 417 396 343 2414 345 283 181 17 225 113 1164 475 376 294 273 284 198 1900 391 341 265 302 335 281 1915 380 297 224 211 149 272 1533 -638 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS Animal Number RECOVERY Successive 10-Minute Intervals I 2 3 4 5 6 Total Group I: 0 mg/kg/day 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 403 280 281 210 126 200 1500 369 358 266 249 150 235 1627 384 316 277 249 224 145 1595 415 275 236 116 152 217 1411 374 350 281 265 256 278 1804 415 336 309 150 165 32 1407 324 287 160 255 85 11 1122 363 263 128 221 254 105 1334 365 136 249 256 24 1 1031 443 340 304 324 273 267 1951 Group VII: 500 mg/kg/day 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 434 364 249 196 284 288 1815 431 358 297 287 203 15 1591 450 296 348 260 216 237 1807 402 288 261 205 163 152 1471 295 214 239 118 84 1 951 299 274 219 193 214 190 1389 311 299 206 300 219 1 1336 423 359 280 311 282 310 1965 419 324 273 206 249 159 1630 424 300 195 265 217 7 1408 -639Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS Animal Number BASELINE Successive 10-Minute Intervals I 2 3 4 5 6 Total Group II: 0 mg/kg/day 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 490 351 147 406 419 199 2012 350 208 131 92 277 107 1165 309 246 163 35 10 0 763 366 307 293 137 6 4 1113 394 324 271 250 117 6 1362 381 295 287 276 99 38 1376 309 212 156 0 5 19 701 307 250 171 194 169 194 1285 397 292 328 393 28 0 1438 326 232 192 174 179 98 1201 Group IV: 25 mg/kg/day 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 366 180 53 0 23 0 622 324 72 180 112 0 2 690 442 344 310 159 178 2 1435 387 297 222 14 6 0 926 318 178 90 36 152 21 795 412 225 191 181 4 0 1013 341 255 250 227 313 116 1502 408 393 308 307 269 32 1717 343 301 263 267 315 228 1717 399 290 49 348 41 5 1132 Group VI: 100 mg/kg/day 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 357 248 297 142 81 8 1133 367 230 138 159 223 91 1208 351 235 65 12 7 0 670 316 230 121 178 67 104 1016 391 326 246 286 280 38 1567 266 105 198 4 38 1 612 428 320 286 344 269 209 1856 285 280 217 135 12 6 935 401 329 151 421 175 13 1490 365 263 310 228 143 114 1423 -640Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS Animal Number BASELINE Successive 10-Minute Intervals I 2 3 4 5 6 Total rroup VIII: 500 mg/kg/day 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 399 260 169 40 1 3 872 324 237 18 138 46 16 779 332 240 157 134 169 91 1123 330 249 205 38 6 0 828 323 217 280 177 197 87 1281 247 173 153 26 86 144 829 371 268 166 35 11 15 866 440 354 293 292 178 99 1656 436 369 320 108 23 10 1266 342 238 90 34 0 0 704 -641 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS Animal Number WEEK 13 Successive 10-Minute Intervals i 2 3 4 5 6 Total Group II: 0 mg/kg/day 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 453 305 273 293 337 407 2068 422 304 127 275 255 132 1515 420 358 344 271 231 283 1907 371 203 274 160 263 0 1271 422 266 249 230 155 2 1324 464 310 367 134 232 8 1515 427 335 249 8 288 293 1600 362 305 227 292 233 127 1546 432 212 170 174 5 67 1060 390 286 225 309 126 219 1555 Group IV: 25 mg/kg/day 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 369 278 217 225 9 63 1161 361 252 114 210 177 209 1323 436 330 237 292 285 278 1858 358 336 281 260 122 199 1556 460 285 160 173 222 152 1452 460 352 150 229 244 286 1721 383 222 130 288 224 249 1496 358 266 221 260 246 142 1493 452 262 183 314 229 252 1692 355 227 251 287 198 204 1522 Group VI: 100 mg/kg/day 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 380 361 193 220 230 202 1586 383 324 232 275 262 215 1691 404 335 371 357 275 256 1998 297 227 189 208 173 201 1295 417 339 227 236 303 162 1684 419 172 207 174 100 185 1257 493 424 431 381 343 359 2431 295 261 143 142 220 162 1223 398 401 84 215 234 227 1559 412 304 287 201 146 230 1580 -642Company Sanitized. Does not contain TSCA CB1 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS WEEK 13 Animal Number Successive 10-Minute Intervals I 2 3 4 5 6 Total Group VIII: 500 mg/kg/day 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 426 279 273 327 347 140 1792 375 349 357 293 269 278 1921 428 288 185 106 193 235 1435 364 228 186 166 103 133 1180 419 306 198 191 248 171 1533 300 288 248 132 75 95 1138 446 333 264 254 168 258 1723 464 351 260 229 283 253 1840 488 360 331 220 430 211 2040 352 264 242 309 291 296 1754 -643Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS Animal Number RECOVERY Successive 10-Minute Intervals I 2 3 4 5 6 Total Group II: 0 mg/kg/day 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 483 366 295 270 141 251 1806 470 483 365 381 268 359 2326 392 278 284 220 291 204 1669 410 313 231 324 251 139 1668 398 267 329 182 13 33 1222 428 357 152 140 245 216 1538 346 257 234 182 64 147 1230 466 381 338 268 161 232 1846 372 270 177 131 87 211 1248 364 258 284 153 145 67 1271 Group VIII: 500 mg/kg/day 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 415 308 275 247 221 254 1720 319 198 217 265 213 221 1433 423 246 236 266 155 292 1618 371 185 168 176 294 162 1356 391 255 236 132 120 198 1332 423 376 351 292 245 210 1897 503 432 308 247 289 195 1974 413 397 292 361 281 103 1847 442 353 259 50 142 107 1353 338 260 234 189 181 57 1259 -644Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX J INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS -645Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS Animal Number 1 Group I: 0 mg/kg/day BASELINE Successive 10-Minute Intervals 2345 6 Total 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 122 141 138 31 11 1 444 140 142 129 125 36 21 593 116 107 115 10 0 339 140 150 140 148 135 140 853 140 148 88 18 7 9 410 123 113 93 18 4 4 355 145 130 114 89 18 2 498 135 113 103 124 34 5 514 155 126 128 79 8 4 500 129 131 146 11 13 7 437 Group III: 25 mg/kg/day 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 137 149 129 127 97 148 162 130 55 1 135 140 109 28 6 158 155 94 6 7 167 141 110 8 8 135 134 58 46 24 146 157 149 154 118 132 134 130 143 120 152 132 147 80 12 137 141 48 24 11 2 641 43 539 13 431 15 435 7 441 8 405 16 740 37 696 3 526 11 372 Group V: 100 mg/kg/day 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 95 123 110 120 73 126 126 107 103 83 142 129 53 6 12 149 143 108 8 11 131 152 158 66 24 108 107 31 4 18 133 113 150 127 146 125 139 144 25 13 115 99 0 3 4 149 117 83 48 13 3 524 13 558 5 347 7 426 12 543 12 280 5 674 4 450 11 232 3 413 -646Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS Animal Number I Group VII: 500 mg/kg/day BASELINE Successive 10-Minute Intervals 2345 6 Total 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 131 129 143 69 9 96 117 133 109 68 131 132 134 94 11 125 136 24 17 13 149 133 124 132 118 91 58 58 23 8 152 129 69 3 5 132 135 16 15 18 111 133 111 34 8 151 135 34 13 20 6 487 4 527 1 503 20 335 8 664 3 241 6 364 7 323 13 410 9 362 -647Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTF/rTY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS Animal Number I Group I: 0 mg/kg/day WEEK 13 Successive 10-Minute Intervals 2345 6 Total 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 147 135 151 132 124 102 791 134 149 108 92 90 70 643 131 153 128 122 143 108 785 139 125 129 102 122 137 754 121 135 140 151 122 134 803 117 120 116 128 84 34 599 139 147 171 123 137 52 769 142 65 19 75 13 21 335 133 125 90 97 119 89 653 111 122 130 145 115 145 768 Group III: 25 mg/kg/day 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 147 143 124 81 103 27 625 152 137 127 110 131 108 765 139 146 151 64 157 114 771 140 136 152 95 117 123 763 142 135 135 153 123 95 783 111 118 125 124 115 134 727 146 166 147 146 132 141 878 126 130 148 126 144 108 782 142 163 149 158 118 91 821 129 129 98 120 115 163 754 Group V: 100 mg/kg/day 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 125 121 127 116 119 82 690 148 147 109 103 130 103 740 140 143 92 6 3 72 456 146 142 125 122 139 144 818 159 121 138 148 109 118 793 121 140 124 97 112 117 711 118 121 99 126 88 74 626 130 137 104 130 126 106 733 108 132 146 119 126 88 719 126 136 155 138 168 134 857 -648Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS Animal Number WEEK 13 Successive 10-Minute Intervals I 2 3 4 5 6 Total Group VII: 500 mg/kg/day 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 138 117 112 105 106 93 671 114 122 105 132 119 113 705 121 135 148 93 125 130 752 122 132 141 119 127 136 777 142 135 124 111 122 126 760 53 67 52 61 59 53 345 167 155 96 16 121 76 631 126 140 131 112 109 101 719 119 128 126 144 117 126 760 151 136 136 155 106 162 846 -649Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS Animal Number I Group I: 0 mg/kg/day RECOVERY Successive 10-Minute Intervals 234 5 6 Total 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 140 156 142 135 103 122 798 145 138 129 125 121 149 807 141 125 149 146 122 88 771 117 127 112 85 96 117 654 148 139 137 143 139 127 833 117 152 138 108 84 19 618 163 136 101 136 81 8 625 129 128 96 110 111 85 659 141 82 138 118 15 6 500 131 156 144 157 157 145 890 Group VII: 500 mg/kg/day 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 125 134 89 79 115 120 662 111 115 114 133 86 9 568 129 144 153 151 108 104 789 158 155 142 102 111 122 790 109 117 111 88 74 7 506 134 131 133 135 127 128 788 125 128 109 127 100 5 594 123 136 111 132 144 109 755 120 143 128 104 131 93 719 132 85 70 96 92 4 479 -650Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS Animal Number I Group II: 0 mg/kg/day BASELINE Successive 10-Minute Intervals 2345 6 Total 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 60 53 21 61 53 12 260 115 104 85 61 136 64 565 160 133 139 38 11 2 483 125 126 151 120 9 5 536 119 119 92 109 70 2 511 143 167 144 125 110 56 745 129 113 80 0 7 9 338 147 158 124 142 112 133 816 130 115 140 135 35 2 557 151 136 124 116 110 89 726 Group IV: 25 mg/kg/day 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 143 122 50 1 21 0 337 124 51 79 61 1 5 321 122 151 124 111 133 6 647 137 134 118 20 4 2 415 133 122 74 33 101 33 496 104 110 102 120 4 5 445 130 130 108 128 151 104 751 117 119 116 141 107 25 625 136 130 146 128 119 131 790 118 138 27 102 26 6 417 Group VI: 100 mg/kg/day 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 123 125 130 110 40 137 140 150 138 139 141 127 46 11 9 137 125 110 130 71 124 128 125 92 153 131 87 143 4 37 98 97 105 101 114 139 138 124 99 23 109 117 74 118 92 131 112 135 106 121 7 535 95 799 5 339 99 672 41 663 2 404 92 607 6 529 21 531 64 669 -651 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS Animal Number i Group VIII: 500 mg/kg/day BASELINE Successive 10-Minute Intervals 2345 6 Total 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 132 124 113 36 4 5 414 125 140 23 73 62 25 448 154 145 114 119 149 104 785 144 150 114 31 10 2 451 144 114 143 117 118 81 717 134 110 116 33 66 119 578 143 125 111 26 15 13 433 110 108 132 119 106 76 651 120 138 108 104 19 12 501 148 146 77 40 0 0 411 -652Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS Animal Number I Group II: 0 mg/kg/day WEEK 13 Successive 10-Minute Intervals 2345 6 Total 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 82 82 73 91 77 71 476 129 144 83 131 139 96 722 124 142 147 146 121 137 817 116 85 101 99 114 3 518 117 122 146 138 95 3 621 133 146 150 97 149 16 691 123 123 103 13 139 117 618 150 161 156 157 150 113 887 118 79 93 123 10 39 462 141 127 135 126 113 124 766 Group IV: 25 mg/kg/day 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 134 143 147 132 22 45 623 138 129 94 102 114 141 718 113 130 123 123 133 133 755 147 138 146 132 113 133 809 142 141 120 100 123 124 750 119 148 80 118 128 127 720 127 137 84 166 140 144 798 135 118 132 137 120 97 739 113 92 103 117 120 124 669 108 110 115 134 121 110 698 Group VI: 100 mg/kg/day 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 155 135 116 115 130 151 802 162 181 148 181 177 147 996 132 130 133 126 128 143 792 137 129 137 143 129 114 789 137 138 132 135 147 134 823 139 130 128 110 72 119 698 70 48 75 61 61 63 378 159 127 105 87 132 123 733 124 114 53 99 133 131 654 113 111 141 137 89 112 703 -653Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS Animal Number i Group VIII: 0 mg/kg/day WEEK 13 Successive 10-Minute Intervals 2 34 5 6 Total 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 117 123 155 129 147 94 765 135 150 133 120 128 134 800 140 152 114 74 119 159 758 138 115 138 115 74 102 682 118 128 115 100 129 108 698 143 140 129 89 55 82 638 135 123 111 125 109 126 729 127 123 127 117 138 132 764 113 129 128 139 132 145 786 147 134 145 153 145 130 854 -654Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS RECOVERY Animal Number I Group II: 0 mg/kg/day Successive 10-Minute Intervals 2 345 6 Total 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 101 124 120 120 89 116 670 69 66 69 45 31 61 341 145 145 138 156 153 128 865 137 146 147 145 128 95 798 130 151 133 82 23 28 547 119 126 102 101 136 149 733 138 127 144 119 80 113 721 116 139 175 144 139 145 858 126 115 110 120 69 130 670 128 140 143 125 122 77 735 Group VIII: 500 mg/kg/day 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 127 126 86 126 116 121 702 129 137 133 104 155 145 803 139 136 100 117 95 147 734 122 117 102 108 139 112 700 152 141 136 116 81 147 773 137 146 123 131 122 113 772 115 152 141 134 127 142 811 120 144 118 156 162 86 786 127 143 147 61 101 104 683 135 143 172 137 153 70 810 - 655 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX K INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA -656Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA ABBREVIATIONS : EXPLANATORY NOTES General: ADEQ - adequate CLOT - sample clotted DECR - decreased NSR - no sample received for testing NT - not taken or not performed OK - sample condition OK for testing QNS - quantity not sufficient for testing RNV - result not valid UTD - unable to determine > greater than < less than Individual Hematology Values: COND - sample condition RBC - red blood cell count HGB - hemoglobin HCT - hematocrit MCV - mean corpuscular volume MCH - mean corpuscular hemoglobin MCHC - mean corpuscular hemoglobin concentration RDW - red cell distribution width ARET - absolute reticulocyte count PLT - platelet count WBC - white blood cell count ANEU - absolute neutrophil (all forms) ALYM - absolute lymphocyte ANPR - absolute neutrophil precursor AMON - absolute monocyte AEOS - absolute eosinophil ABAS - absolute basophil ALUC - absolute large unstained cell ABLT - absolute blast leukocyte AMSC - absolute miscellaneous leukocyte AHSN - absolute hypersegmented neutrophil ABAN - absolute neutrophil band AMET - absolute neutrophil metamyelocyte AMYE - absolute neutrophil myelocyte APRO - absolute neutrophil promyelocyte AMYB - absolute neutrophil myeloblast ARL - absolute reactive lymphocyte AAL - absolute atypical lymphocyte AIL - absolute immature lymphocyte ACL - absolute clefted lymphocyte ABLB - absolute lymphoblast AIE _ absolute immature eosinophil AIM - absolute immature monocyte APLA - absolute plasma cell count DuPont-5990 -657 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (CONTINUED) ABBREVIATIONS : (Continued) Individual Red Blood Cell Morphology values: NORM normal ANIS anisocytosis MIC microcytes MAC macrocytes POLY polychromasia HYPO hypochromasia ECHI echinocytes ACAN acanthocytes TARG target cells RX rouleaux HJB Howell-Jolly body SPEC special observations not observed or not examined; see whole blood sample condition Individual White Blood Cell / Platelet Morphology Values: NORM normal SM smudge white blood cells TOX toxic neutrophils DB DOhle bodies VC vacuolated cytoplasm PC platelet clumps (graded as 1 if present at any level) PCE platelet clumps / estimate GP giant platelets BP bizarre platelets SPEC special observations not observed or not examined; see whole blood sample condition Individual Coagulation Values: PHEM plasma hemolysis PLIP plasma lipemia PICT plasma icterus PT prothrombin time APTT activated partial thromboplastin time SPEC special observations DuPont-5990 -658Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (CONTINUED) ABBREVIATIONS : (Continued) Individual Serum and Plasma Chemistry Values: SHEM - serum hemolysis SLIP - serum lipemia SICT - serum icterus AST - aspartate aminotransferase ALT - alanine aminotransferase SDH - sorbitol dehydrogenase ALKP - alkaline phosphatase BILI - total bilirubin BUN - urea nitrogen CREA - creatinine CHOL - cholesterol TRIG - triglycerides GLUC - glucose TP - total protein ALB - albumin GLOB - globulin CALC - calcium IPHS - inorganic phosphorous NA - sodium K - potassium CL - chloride PHEM - plasma hemolysis from blood sample for fluoride determination PLIP - plasma lipemia from blood sample for fluoride determination PICT - plasma icterus from blood sample for fluoride determination PFLU - plasma fluoride SPEC - special observations Individual Urinalysis Values: QUAL - quality (modifies color) COL - color CLAR - clarity VOL - volume UOSM - urine osmolality SG - specific gravity PH - the logarithm of the reciprocal of the hydrogen ion concentration UGLU - urine glucose KET _ ketone UBIL - urine bilirubin BLD _ blood URO - urobilinogen UFLU - urine fluoride UMTP - urine protein SPEC - special observations Individual Urine Microscopic Examination Values: EPIT - epithelial cells UWBC - urine white blood cells URBC - urine red blood cells NCRY - normal crystals MICR - mic roorgani sms SPER - sperm SPEC - special observations DuPont-5990 -659Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (CONTINUED) KEY: Rad Blood Cell Morphology Values, White Blood Cell / Platelet Morphology Values exception of Platelet Clumps), and Special Observations: 1 - trace 2 - few 3 - moderate 4 - many (with the Platelet clumps will be graded as 1 if present in any amount. Urine Microscopic Values: EPIT NCRY/MICR SPERM/MUCUS CASTS per high power field per high power field per low power field per low power field _______ (4Ox)__________________ (40x)_______________________ (lOx)____________________ 1lOx)________ few 1-10 few - 1-25%/field 1 - 1-5 few - 1-10 moderate - 11-50 moderate 26-50%/field 2 - 6-20 moderate 11-50 many - >50 many - >50%/field 3 - >20 many >50 NOTES: When individual animal data are not reported, it may be due to one of the following reasons or other reasons, all of which are explained in the study records.- the sample was clotted (CLOT) there was insufficient sample for testing (QNS) a valid result could not be obtained (RNV) the sample was not suitable for testing the animal died prior to sample collection no sample was available for testing (NSR) When an individual observation was recorded as being less than a certain value, calculations were performed on half the recorded value. For example, if bilirubin was reported as <0.1, 0.05 was used for any calculations performed with that bilirubin data. When an individual observation was recorded as being greater than a certain value, calculations were performed on the recorded value. For example, if specific gravity was reported as >1.083, 1.083 was used for any calculations performed with that specific gravity data. -660Company Sanitized. Does not contain TSCA C8I )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________________ DuPont-5990 Animal Number COND RBC xlO-'6//iL RGB g/dL Male, Group: I - 0 mg/kg - Day 39 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 OK 7.75 14.4 OK 8.39 15.3 OK 8.13 15.0 OK 8.67 15.2 OK 7.78 13.8 OK 8.54 15.5 OK 7.96 14.9 OK 8.30 15.1 OK 7.72 14.8 OK 7.86 14.5 Male, Group: III - 25 mg/kg - Day 39 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 OK 8.31 15.3 OK 7.70 14.9 OK 7.58 14.2 OK 8.28 14.9 OK 8.10 14.8 OK 8.38 15.1 OK 7.94 15.0 OK 7.86 14.8 OK 7.73 13.9 OK 7.50 14.7 Individual Hematology Values HCT MCV MCH MCHC % fL pg g/dL RDW ARET PLT WBC % xlOrt3/nL x I O ^ / m L x 10~3/m L 46.2 50.0 48.0 49.5 45.3 49.7 47.4 48.7 48.1 45.9 49.5 47.0 46.2 48.5 48.6 48.8 48.0 47.4 46.6 45.8 59.6 59.6 59.0 57.1 58.3 58.2 59.6 58.7 62.3 58.5 59.6 60.9 60.9 58.6 60.0 58.2 60.5 60.3 60.3 61.2 18.5 18.2 18.4 17.5 17.7 18.2 18.7 18.3 19.1 18.4 18..4 19..3 18..8 18,.0 18..3 18.,0 18..9 18..8 18..0 19..7 31.1 30.5 31.2 30.7 30.4 31.3 31.3 31.1 30.7 31.5 30..8 31 .6 30 .8 30 .8 30..5 30..9 31 .3 31..2 29..9 32..1 10.7 11.3 11.6 10.4 11.2 11.8 10.9 10.6 11.7 11.1 11 .2 10 .9 11 .8 11 .9 11..2 11..2 11..2 10..8 13..7 11..4 187. 227 . 218. 181. 181. 215. 142. 194. 241. 212. 164. 202. 252. 204. 192. 191. 190. 184. 492. 206. 920 1001 1070 810 1067 1050 1186 808 964 1257 12.31 13.60 16.59 14.58 14.78 16.16 12.78 9.45 12.27 15.66 RNV 1197 971 983 1381 1137 874 RNV 1139 987 16..20 16..29 11..66 12 .51 17,.12 19..78 13..91 22..81 14..05 17..13 Company Sanitized. Does not contain TSCA CBI -661 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations > DuPont-5990 Animal Number COND RBC xlO'^6/iih HGB g/dL Male, Group: V - 100 mg/kg - Day 39 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 OK 7..89 13 ,9 OK 7 .66 14 .6 OK 7 .90 15..5 OK 8..06 14..7 OK 7..94 14..7 OK 8 .11 15 .0 OK 8..22 15 .5 OK 8 .43 14 .5 OK 8,.00 14..1 OK 8..15 14..9 Male, Group: VII - 500 mg/kg - Day 39 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 OK 8,.33 14 .2 OK 8..52 14 .4 OK 8 .64 14 .2 OK 8 .10 14 .2 OK 7 .82 14..1 OK 8..74 15..1 OK 7 .89 13..9 OK 7..92 14..0 OK 8..45 14..4 OK 8..05 14 .6 Individual Hematology Values HOT MCV MCH MCHC % fL p g g/dL 44.,5 46..8 48.,8 48..0 47..5 48..1 48..6 46..5 45,.6 47..1 45..9 45..6 46,.0 45,.0 45.,0 48..6 44..0 46.,0 46..3 46..5 56..4 61..1 61..8 59,.5 59..8 59,.3 59..1 55 .2 57,.0 57,.8 55..1 53..6 53 .3 55 .6 57..5 55..7 55..8 58,.0 54..8 57..8 17 .6 19..1 19..6 18..2 18..5 18..5 18..8 17..2 17..7 18..3 17..0 16,.9 16..4 17..6 18..0 17..3 17..6 17.,7 17..0 18..2 31..2 31..3 31..7 30,.6 30..9 31 .1 31..9 31 .2 31..0 31..6 30.9 31.6 30.8 31.6 31.3 31.1 31.6 30.5 31.0 31.4 RDW ARET PLT WBC % x 10~3/m L x 10~3/m L xlO^l/nL 11..6 11..4 11..5 11..1 11..5 12 .0 10 .9 11 .5 11..7 12 .0 13.0 11.1 11.8 12.1 11.2 11.5 13.0 13.1 12.2 12.4 203. 169. 191. 226. 188. 253. 193. 209. 275. 213. 171. 202. 207. 167. 225. 141. 248. 265. 316. 255. 1124 978 900 1066 1108 RNV 1130 RNV 943 942 15..47 15..18 17..67 15..37 15..02 18 .02 11 .79 16 .34 14..41 14..93 807 952 1221 1068 1051 881 1186 1020 RNV 1068 16.69 15.68 18.00 16.92 14.49 17.26 13.47 21.05 14.60 13.20 Company Sanitized. Does not contain TSCA CBI -662- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number ANEU x 10^3/m L ANPR xlO A3/ixL ALYM xlO~3//iL Individual Hematology Values AMON AEOS ABAS ALUC xl0"3/iiL xlO~3/iiL x 10~3/m L xl0"3/i<L ABLT x 10~3/m L AMSC x l O ^ /(ih Male, Group: I - 0 mg/kg - Day 39 646360 1 .22 NT 10..38 0..34 0..16 0,.13 0..09 NT NT 646367 1 .86 NT 11..25 0..19 0..03 0..12 0..14 NT NT 646374 1 .21 NT 14..78 0..24 0..07 0..17 0..13 NT NT 646379 1 .04 NT 12..61 0..40 0..23 0..18 0..12 NT NT 646420 2 .26 NT 11 .72 0..39 0..06 0..20 0..15 NT NT 646427 1 .11 NT 14 .46 0..22 0..11 0 .12 0..15 NT NT 646482 1,.59 NT 10,.41 0.,29 0. 18 0..20 0..12 NT NT 646485 1..87 NT 7..01 0..29 0..10 0..12 0..07 NT NT 646489 1 .12 NT 10..31 0.,41 0..10 0..12 0..21 NT NT 646492 1 .76 NT 13..18 0..25 0..12 0..20 0,,17 NT NT Male, Group: III - 25 mg/kg - Day 39 646370 1 .00 NT 14..44 0..37 0..12 0 .11 0..17 NT NT 646399 1 .72 NT 13 .73 0,.39 0..10 0 .18 0..16 NT NT 646414 1 .73 NT 8 .94 0..47 0..16 0 .20 0..16 NT NT 646421 2 .15 NT 9 .65 0..35 0..09 0 .17 0..10 NT NT 646423 2 .37 NT 13..75 0..52 0..16 0..18 0..14 NT NT 646426 3 .03 NT 15..75 0..53 0..05 0..17 0..26 NT NT 646443 1 .65 NT 11..54 0..36 0..07 0..16 0..12 NT NT 646454 2 .07 NT 19..74 0..48 0..11 0..19 0..23 NT NT 646458 1..39 NT 11 .87 0..33 0..11 0..16 0..20 NT NT 646471 1 .70 NT 14 .41 0..48 0..13 0 .17 0,.24 NT NT DuPont-5990 Company Sanitized. Does not contain TSCA CBI -663 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number ANEU xlO ^3/m L ANPR xl0~3///L ALYM xl0A3/jiL Individual Hematology Values AMON AEOS ABAS ALUC xl0"3/ML x 10a 3/m L x 10a 3/m L xlOA3/fiL ABLT xlO^i/h AMSC xlO^l/h Male, Group: V - 100 mg/kg - Day 39 646349 2 .65 NT 11..77 0..55 0..13 0,.19 0..17 NT NT 646373 1 .63 NT 12..61 0..47 0.,13 0..19 0..15 NT NT 646385 2 .38 NT 14..07 0..54 0..30 0.,16 0..22 NT NT 646435 1 .95 NT 12 .53 0..48 0..07 0..13 0..22 NT NT 646455 1 .53 NT 12..46 0..39 0..14 0..27 0,.22 NT NT 646456 1 .71 NT 15 .46 0..45 0..14 0..14 0..12 NT NT 646463 0 .98 NT 10 .11 0,.31 0..08 0..14 0..16 NT NT 646469 1 .96 NT 13..44 0..49 0..10 0..13 0..21 NT NT 646472 1 .23 NT 12..30 0..56 0..07 0..11 0,.13 NT NT 646488 1 .90 NT 11 .93 0..77 0..12 0..13 0..09 NT NT Male, Group:; VII - 500 mg/kg - Day 39 646343 1 .46 NT 14 .30 0..44 0..10 0 .15 0..23 NT NT 646346 2 .02 NT 12 .62 0 .64 0 .15 0 .12 0 .14 NT NT 646347 1 .51 NT 15 .65 0..40 0..13 0 .16 0 .15 NT NT 646388 1 .83 NT 14 .07 0..63 0..11 0 .14 0 .14 NT NT 646407 1 .65 NT 11..54 0 .76 0..20 0..14 0..20 NT NT 646413 1 .54 NT 14..90 0..39 0..14 0..11 0..17 NT NT 646433 1 .46 NT 11..03 0,.50 0..11 0..22 0..14 NT NT 646437 1 .82 NT 17,.93 0..66 0..23 0..25 0..16 NT NT 646442 1 .03 NT 12..67 0,.51 0..09 0..14 0..16 NT NT 646475 1 .18 NT 11..27 0..24 0..21 0..12 0..19 NT NT DuPont-5990 Company Sanitized. Does not contain TSCA CBI -664- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Animal Number COND RBC x10^6/m L HGB g/dL Male, Group: I - 0 mg/kg - Day 95 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 OK 8.26 15.2 OK 8.54 15.5 OK 8.91 15.6 OK 9.24 16.0 OK 8.04 14.2 OK 9.29 16.2 OK 8.51 15.4 OK 8.93 15.9 OK 8.34 15.3 OK 8.27 14.6 Male, Group: III - 25 mg/kg - Day 95 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 OK 8.73 15.6 OK 8.58 15.7 OK 7.86 14.1 OK 8.51 15.0 OK 8.59 15.3 OK 9.34 16.3 OK 8.31 15.1 OK 8.61 15.4 OK 9.06 15.4 OK 8.38 15.3 Individual Hematology Values HOT MOV MCH MCHC % fL p g g/dL 46.2 48.1 48.2 49.6 44.4 49.7 46.0 49.4 47.6 44.4 47.5 48.1 42.7 45.7 47.0 49.4 46.8 46.7 47.3 47.0 55.9 56.3 54.2 53.7 55.2 53.4 54.1 55.3 57.1 53.7 54.4 56.1 54.3 53.7 54.6 52.9 56.3 54.3 52.2 56.0 18.4 18.2 17.5 17.4 17.7 17.5 18.1 17.8 18.3 17.6 17.9 18.3 17.9 17.7 17.8 17.4 18.1 17.9 17.0 18.3 32.9 32.3 32.3 32.3 32.0 32.7 33.4 32.2 32.1 32.8 33.0 32.6 32.9 32.9 32.5 32.9 32.2 33.0 32.5 32.7 RDW ARET PLT WBC % xlO^ / h x 10a 3/m L x 10a 3/m L 12.4 12.5 14.2 12.3 13.7 13.2 13.3 12.9 14.9 14.1 12.9 13.1 15.3 14.5 12.8 13.9 13.2 12.5 14.8 13.6 223. 216. 225. 156. 171. 176. 127. 185. 201. 230. 171. 205. 247. 207. 138. 176. 160. 152. 176. 211. RNV 956 RNV 954 1241 RNV RNV 1042 RNV 1414 10.79 6.33 14.08 12.38 30.78 12.48 7.92 10.94 8.50 13.42 RNV 1232 1179 1033 1383 909 RNV 856 1110 1093 10.69 15.69 7.17 9.16 12.32 17.09 11.98 12.32 11.19 16.13 Company Sanitized. Does not contain TSCA O CD H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 Animal Number COND RBC x 10a 6/m L HGB g/dL Male, Group: V - 100 mg/kg - Day 95 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 OK 8.64 14.5 OK 8.28 14.6 OK 8.12 14.9 OK 8.18 14.1 OK 7.95 14.4 OK 9.11 15.8 OK 8.62 14.7 OK 9.19 15.3 OK 7.84 13.6 OK 9.02 15.3 Male, Group: VII - 500 mg/kg - Day 95 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 OK 9.06 14.0 OK 9.03 14.7 OK 9.62 14.2 OK 9.09 14.1 OK 8.39 14.4 OK 8.56 13.4 OK 8.91 14.2 OK 8.48 14.5 OK 8.90 14.1 OK 8.50 14.1 Individual Hematology Values HCT MCV MCH MCHC % fL p g g/dL 45.0 45.8 46.9 43.9 44.0 48.7 45.0 48.1 42.5 47.5 43.5 44.3 45.7 44.5 44.8 42.2 44.5 44.9 45.9 44.0 52.1 55.2 57.7 53.7 55.3 53.4 52.1 52.4 54.2 52.7 48.0 49.0 47.5 49.0 53.5 49.3 50.0 52.9 51.6 51.8 16.8 17.6 18.3 17.3 18.1 17.3 17.0 16.6 17.3 17.0 15.5 16.2 14.8 15.5 17.1 15.6 16.0 17.1 15.8 16.6 32.3 31.9 31.7 32.2 32.8 32.4 32.6 31.8 31.9 32.2 32.2 33.1 31.1 31.7 32.1 31.7 32.0 32.4 30.7 32.0 RDW ARET PLT WBC % x 10a 3/m L x 10a 3/m L x 10a 3/m L 14.3 15.1 14.0 13.6 14.2 14.9 14.2 14.3 13.8 14.2 14.9 13.4 14.8 16.3 14.5 14.7 15.5 14.8 15.6 15.2 219. 213 . 195. 266. 205. 263. 200. 224. 353 . 216. 207. 200. 227. 244. 254. 250. 262. 236. 371. 272. 1177 1263 965 RNV 1259 1112 1178 986 1211 1315 11.59 12.33 15.36 12.96 11.48 9.80 8.77 12.08 12.34 9.85 1018 1083 1491 1380 1253 1330 1267 1147 RNV RNV 14.86 9.25 12.29 11.72 10.71 12.44 12.06 15.73 11.16 12.90 Company Sanitized. Does not contain TSCA CBI -666- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal ANEU ANPR Number xlOn3/L x 10~3/m L Individual Hematology Values ALYM AMON AEOS ABAS ALUC x! 0 ~ 3 / mL xlO~3/L x 10"3/m L xlO^i/h xl0~3/fiL ABLT xlO^/nL AMSC xlO^Z/h Male, Group: I - 0 mg/kg - Day 95 646360 1..55 NT 8.,54 0..36 0.,14 0.,05 0..13 NT NT 646367 1..80 NT 4..24 0..09 0..06 0..06 0..08 NT NT 646374 1..36 NT 11..91 0..25 0..16 0..19 0..21 NT NT 646379 1..33 NT 10..25 0..25 0..21 0..17 0,.17 NT NT 646420 19..35 NT 9..70 0..94 0.,07 0..17 0..55 NT NT 646427 1 .43 NT 10..54 0..22 0..14 0..04 0 .11 NT NT 646482 1 .12 NT 6,.27 0,.22 0,.15 0..06 0..10 NT NT 646485 2 .60 NT 7..76 0..25 0..11 0..11 0..10 NT NT 646489 1 .18 NT 6..60 0,.18 0..15 0..06 0 .33 NT NT 646492 1 .58 NT 11..07 0..27 0..17 0,.14 0..18 NT NT Male, Group: III - 25 mg/kg - Day 95 646370 1..84 NT 8,.39 0..19 0..09 0..07 0..11 NT NT 646399 2..82 NT 11..89 0..45 0..24 0..06 0..24 NT NT 646414 1..56 NT 5,.27 0..13 0..09 0..04 0..09 NT NT 646421 1..91 NT 6..64 0,.23 0..09 0..13 0..18 NT NT 646423 2 .29 NT 9..30 0..22 0..26 0,.14 0 .11 NT NT 646426 2 .22 NT 14..13 0..37 0..09 0,.07 0 .21 NT NT 646443 1..77 NT 9..35 0,.44 0..11 0..13 0 .18 NT NT 646454 1..44 NT 10..29 0..23 0..15 0,.05 0 .16 NT NT 646458 1 .93 NT 8 .64 0 .23 0..11 0..08 0 .19 NT NT 646471 2 .16 NT 12,.92 0..37 0,.28 0..19 0 .22 NT NT ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -667- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number ANEU xlO ~3/m L ANPR x!0~3/L ALYM xl0A3//;L Individual Hematology Values AMON AEOS ABAS ALUC x l O ^ / y L x !0^3/m L x !0a 3/m L x !0^3/m L ABLT xlQ*3/L AMSC xlQn3/L Male, Group:: V - 100 mg/kg - Day 95 646349 2 .60 NT 8..15 0..34 0,.20 0..09 0..21 NT NT 646373 1 .84 NT 9..78 0..22 0..20 0.,11 0.,18 NT NT 646385 1 .91 NT 12..64 0..36 0..28 0.,08 0,.09 NT NT 646435 2 .11 NT 10..27 0..27 0..09 0..07 0.,16 NT NT 646455 2 .00 NT 8..75 0..35 0..14 0.,16 0,.08 NT NT 646456 1 .80 NT 7..38 0..19 0 .20 0..07 0..17 NT NT 646463 1 .57 NT 6..54 0..27 0 .11 0..05 0..22 NT NT 646469 1 .84 NT 9..61 0..26 0 .15 0..07 0..15 NT NT 646472 1 .24 NT 10..35 0..37 0..10 0..05 0..24 NT NT 646488 0 .99 NT 8..32 0..23 0..12 0..12 0.,07 NT NT Male, Group:: VII - 500 mg/kg - Day 95 646343 1 .60 NT 12..36 0..28 0 .19 0..26 0..18 NT NT 646346 1 .68 NT 7..04 0..27 0 .11 0..04 0..11 NT NT 646347 1 .55 NT 9..97 0..27 0 .25 0..12 0..14 NT NT 646388 2 .88 NT 8..13 0..29 0 .10 0..06 0..25 NT NT 646407 2 .05 NT 7..98 0..20 0 .14 0..15 0..19 NT NT 646413 2 .02 NT 9..82 0..19 0..16 0..09 0..17 NT NT 646433 1 .43 NT 9,.79 0..34 0 .16 0..12 0..21 NT NT 646437 2 .31 NT 12..30 0..49 0 .17 0..22 0..24 NT NT 646442 2 .04 NT 8,.48 0..24 0..14 0..13 0..13 NT NT 646475 1 .74 NT 10..38 0..25 0 .31 0..03 0..18 NT NT DuPont-5990 Company Sanitized. Does not contain TSCA CBI -668- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number COND RBC x 10a 6/m L HGB g/dL Male, Group : I - 0 mg/kg - Day 123 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 OK CLOT OK OK OK OK OK OK OK OK 9.25 NT 8.18 8.67 8.85 8.59 8.42 8.58 7.93 9.10 16.6 NT 15.1 14.8 15.1 15.7 15.2 15.8 14.7 15.1 Male, Group: VII - 500 mg/kg - Day 123 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 OK 9.22 14.6 OK 7.90 14.7 OK 8.31 14.3 OK 8.28 14.2 OK 8.13 14.6 OK 8.37 14.7 OK 7.99 14.3 OK 8.82 15.5 OK 8.27 14.7 OK 8.05 13.8 Individual Hematology Values HCT MCV MCH MCHC % fL p g g/dL 48.8 NT 44.9 44.2 45.7 46.3 45.8 47.4 44.6 45.8 45.1 44.1 43.8 43.6 43.7 44.3 43.6 47.4 45.7 40.3 52.8 NT 54.9 51.0 51.6 53.8 54.4 55.2 56.2 50.3 48.9 55.9 52.6 52.6 53.8 52.9 54.6 53.8 55.3 50.1 18.0 NT 18.4 17.1 17.0 18.3 18.1 18.4 18.5 16.6 15.8 18.6 17.2 17.2 18.0 17.6 18.0 17.6 17.8 17.2 34.1 NT 33.5 33.5 33.0 33.9 33.2 33.4 32.9 33.0 32.4 33.3 32.6 32.7 33.4 33.3 32.9 32.6 32.2 34.3 RDW ARET PLT WBC % x 10a 3/xL x !0a 3/m L x I O ^ / m L 12.9 NT 12.7 12.5 13.2 12.1 13.1 12.3 13.1 12.7 163. NT 201. 190. 184. ' 131. 235. 218. 229. 136. 16.7 16.2 17.3 14.8 18.5 16.2 14.9 17.1 15.1 17.8 200. 208. 222. 177. 263. 248. 209. 266. 178. 252. RNV NT 1002 RNV 1093 RNV RNV RNV 1188 1106 8.62 NT 7.60 6.91 10.35 14.71 10.05 20.40 15.47 9.00 RNV 1248 1144 1166 1106 RNV 1094 RNV 1246 1461 12.08 13.21 10.53 8.49 16.61 8.25 13.64 10.76 11.48 12.57 Company Sanitized. Does not contain TSCA CBI -669- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number ANEU xlO a 3/m L ANPR xlO ~3/L ALYM x 10~3/m L Individual Hematology Values AMON AEOS ABAS ALUC x I O ^ / m L xlO^i/h xl0~3/*iL x l O ^ / a L ABLT xl0^3/h AMSC xl0~3/L Male, Group;; I - (3 mg/kg - Day 123 646371 i .00 NT 7 .28 0 .15 0..07 0 .07 0..05 NT NT 646398 NT NT NT NT NT NT NT NT NT 646411 i .34 NT 5 .90 0 .20 0 .08 0 .03 0..05 NT NT 646416 i .68 NT 4..92 0 .14 0..09 0..04 0..05 NT NT 646432 i .76 NT 8 .01 0 .37 0..05 0 .09 0..07 NT NT 646446 i .30 NT 12 .64 0 .45 0..13 0 .09 0..10 NT NT 646459 i .28 NT 8 .22 0 .24 0..11 0 .12 0..07 NT NT 646460 6 .74 NT 12 .53 0 .60 0..12 0 .20 0..22 NT NT 646487 1 .53 NT 12 .96 0 .29 0 .24 0 .17 0 .28 NT NT 646494 1 .27 NT 7 .25 0 .27 0 .08 0 .07 0 .05 NT NT Male, Group;: VII - 500 mg/kg - Day 123 646337 1 .33 NT 10 .14 0 .25 0 .19 0 .08 0 .09 NT NT 646364 1 .85 NT 10 .78 0 .20 0 .07 0 .16 0 .16 NT NT 646369 1 .71 NT 8 .33 0 .22 0 .15 0 .05 0 .08 NT NT 646372 1 .63 NT 6 .49 0 .19 0 .09 0 .04 0 .04 NT NT 646384 2 .37 NT 13 .44 0 .40 0 .12 0 .09 0 .18 NT NT 646397 1 .63 NT 6 .22 0 .16 0 .08 0 .11 0 .05 NT NT 646428 2 .11 NT 10 .94 0 .33 0 .08 0 .06 0 .12 NT NT 646448 2 .21 NT 7 .89 0 .35 0 .13 0 .06 0 .11 NT NT 646474 2 .42 NT 8..52 0 .25 0 .03 0 .17 0 .08 NT NT 646484 2 .98 NT 8..61 0 .48 0..29 0 .12 0 .08 NT NT DuPont-5990 Company Sanitized. Does not contain TSCA C8I -670- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number COND RBC x!0rt6//iL HGB g/dL Male, Group: I - 0 mg/kg - Day 183 646325 646396 646468 646495 OK OK OK CLOT 8.80 9.40 8.17 NT 15.1 15.3 15.9 NT Male, Group: III - 25 mg/kg - Day 183 646368 646436 646438 646449 646453 OK 8.38 15.8 OK 8.91 14.9 OK 8.69 16.5 OK 8.87 15.3 OK 8.70 15.0 Male, Group: V - 100 mg/kg - Day 183 646327 646335 646376 646403 OK 9.20 15.8 OK 8.24 14.5 OK 8.58 14.8 OK 8.35 15.3 Male, Group: VII - 500 mg/kg - Day 183 646344 646355 646361 646391 646466 OK OK OK CLOT OK 8.33 7.95 9.21 NT 8.51 16.1 14.8 15.3 NT 14.5 Individual Hematology Values HCT MCV MCH MCHC % fL pg g/dL 46.5 47.1 46.4 NT 47.8 45.7 48.3 48.3 44.6 50.8 44.2 45.4 45.3 50.4 43.4 48.3 NT 45.2 52.8 50.1 56.8 NT 57.0 51.3 55.6 54.4 51.3 55.2 53.7 52.9 54.3 60.5 54.6 52.4 NT 53.1 17.2 16.3 19.5 NT 18.9 16.7 19.0 17.2 17.2 17.2 17.6 17.2 18.3 19.3 18.6 16.6 NT 17.0 32.5 32.5 34.3 NT 33.1 32.6 34.1 31.7 33.6 31.1 32.8 32.6 33.7 31.9 34.1 31.7 NT 32.1 RDW ARET PLT WBC % xl0A3//xL x !0~3/m L xlOA3/^L 13.9 13.5 13.6 NT 12.6 13.9 14.0 14.0 13.7 15.5 15.3 13.9 14.1 13.4 13.5 14.3 NT 13.0 149. 144. 159. NT 221. 167. 137. 186. 141. 224. 210. 147. 144. 203. 145. 188. NT 211. 937 1271 934 NT 9.92 7.78 10.38 NT 1016 1126 1047 1048 1183 7.23 10.27 8.31 10.08 9.67 RNV 1309 1019 RNV 9.54 13.16 9.17 9.40 973 1062 1166 NT 1219 16.27 10.42 10.38 NT 8.73 Company Sanitized. Does not contain TSCA CBI -671 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Animal Number ANEU xlO ~3//jL ALYM xl0"3/iiL AMON x 10a 3/m L Individual Hematology Values AEOS ABAS ALUC ABLT x 10a3/m L x 1CT3/m L x 10~3/m L xlOn3/h AHSN x 1(T3/m L ABAN xIO^/mL AMET x 10/'3/m L AMYE xl0^3/h Male, Group:; I - 0 mg/kg - Day 183 646325 646396 646468 646495 2.03 1.92 1.75 NT 7.23 5.27 7.69 NT 0.32 0.22 0.42 NT Male, Group:: III - 25 mg/kg - Day 183 646368 646436 646438 646449 646453 1.27 1.45 1.50 1.24 2.75 5.58 8.39 6.22 8.46 6.43 0.13 0.13 0.22 0.16 0.16 Male, Group:: V - 100 mg/kg - Day 183 646327 646335 646376 646403 2.53 2.13 2.15 2.49 6.49 10.38 6.68 6.40 0.24 0.22 0.12 0.20 Male, Group: VII - 500 mg/kg - Day 183 646344 646355 646361 646391 646466 1.76 2.81 1.81 NT 1.67 13.72 7.29 8.07 NT 6.41 0.49 0.31 0.23 NT 0.16 0.14 0.16 0.09 NT 0.07 0.08 0.15 0.08 0.16 0.11 0.14 0.11 0.09 0.11 0.00 0.09 NT 0.14 0.10 0.03 0.25 NT 0.10 0.09 0.12 0.03 0.05 0.09 0.09 0.06 0.12 0.11 0.00 0.05 NT 0.24 0.09 0.19 0.17 NT 0.09 0.12 0.09 0.11 0.12 0.09 0.18 0.05 0.09 0.10 0.00 0.13 NT 0.11 NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT Company Sanitized. Does not contain TSCA CBI -672- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 Animal APRO AMYB Number x 10"3/m L xlO~3/aL ARL xlO^ / L Individual Hematology Values AAL AIL ACL ABLB x l O ^ / M L x 1 0 " 3 / mL x 1 0 ~ 3 / mL x l O n 3 / h AIE x lO ^/aL AIM xlO'3/(xL APLA x!0"3/nL Male, Group: I - 0 mg/kg - Day 183 646325 NT NT NT 646396 NT NT NT 646468 NT NT NT 646495 NT NT NT Male, Group: III - 25 mg/kg -- Day 183 646368 NT NT NT 646436 NT NT NT 646438 NT NT NT 646449 NT NT NT 646453 NT NT NT Male, Group: V - 100 mg/kg - Day 183 646327 NT NT NT 646335 NT NT NT 646376 NT NT NT 646403 NT NT NT Male, Group: VII - 500 mg/kg - Day 183 646344 646355 646361 646391 646466 NT 0.00 NT NT NT NT 0 .00 NT NT NT NT 0 .00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT Company Sanitized. Does not contain TSCA CBI - 673 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 Animal Number COND RBC xlO^S/h HGB g/dL Female, Group: II - 0 mg/kg - Day ` 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 OK 7.52 OK 6.57 OK 8.48 OK 8.14 OK 7.50 OK 8.04 OK 8.07 OK 7.98 OK 7.69 OK 8.07 Female, Group: IV - 25 mg/kg - Day 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 OK 8.20 OK 8.06 OK 7.77 OK 7.77 OK 7.60 OK 7.43 OK 7.56 OK 8.37 OK 8.06 OK 7.74 14.3 13.5 15.2 15.0 14.3 14.8 15.5 14.7 14.4 15.1 14..4 15..3 14,.9 14..8 14 ,1 14..6 14,.2 15,.7 15.,8 14..6 Individual Hematology Values HCT MCV MCH MCHC % fL pg g/dL 44.1 42.6 47.4 45.5 43.9 46.4 48.4 45.7 43.8 48.2 45,.8 47..7 46..9 45..3 44..4 44..9 44..4 48..0 49.,0 46..1 58.7 64.8 55.9 55.9 58.6 57.8 59.9 57.2 57.0 59.7 55..9 59..1 60.,3 58..3 58.,4 60..5 58.,8 57..3 60.,8 59..5 19.0 20.6 18.0 18.5 19.1 18.4 19.2 18.4 18.7 18.7 17..6 19..0 19..2 19,.1 18..5 19..7 18.,7 18..8 19..6 18..9 32.4 31.7 32.1 33.1 32.5 31.8 32.1 32.1 32.8 31.3 31.4 32.1 31.8 32.7 31.7 32.6 31.8 32.7 32.3 31.8 RDW ARET PLT WBC % x I O ^ / m L x 10"3/m L xlO~3/iiL, 10.3 13.8 11.2 11.2 11.4 10.3 11.2 10.5 10.9 12.0 10.9 10.7 11.5 10.7 11.5 11.1 11.5 10.9 10.5 11.5 202. 221. 141. 186. 249. 136. 211. 205. 194. 243. 189. 179. 218. 126. 155. 219. 204. 162. 241. 207. 1068 RNV 1028 1200 1235 1053 1226 1193 1166 900 7.42 11.03 10.02 11.44 7.72 11.28 15.95 14.30 9.59 9.06 1434 RNV 1286 986 1323 1345 1220 RNV RNV 1097 16.45 10.32 9.43 16.12 9.50 13.44 12.06 18.03 16.19 9.64 Company Sanitized. Does not contain TSCA CBI -674- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number COND RBC xlCr6/ML HGB g/dL Female, Group: VI - 100 mg/kg - Day 40 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 OK 6.60 12.4 OK 7.20 13.4 OK 6.74 13.6 OK 7.88 14.3 OK 7.30 13.4 OK 7.41 14.5 OK 7.60 14.4 OK 7.41 13.8 OK 7.50 14.0 OK 7.33 13.7 Female, Group: VIII - 500 mg/kg - Day 40 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 OK OK OK OK CLOT OK OK OK OK OK 6.86 7.42 7.27 7.29 NT 7.81 7.74 7.14 6.81 7.03 13.1 13.2 13.4 12.9 NT 14.5 13.9 13.9 12.5 12.6 Individual Hematology Values HCT MCV MCH MCHC % fL p g g/dL 38.8 43.0 42.1 45.0 42.9 44.7 44.8 43.6 44.4 42.5 41.3 42.2 42.2 41.3 NT 48.3 45.5 42.8 40.4 39.3 58.8 59.7 62.4 57.1 58.8 60.3 59.0 58.9 59.1 58.0 60.1 56.9 58.0 56.6 NT 61.9 58.7 59.9 59.3 55.9 18.8 18.6 20.2 18.1 18.3 19.6 19.0 18.6 18.6 18.7 19.0 17.8 18.5 17.7 NT 18.5 18.0 19.4 18.3 17.9 32.1 31.2 32.3 31.7 31.2 32.5 32.2 31.6 31.5 32.2 31.7 31.2 31.8 31.4 NT 30.0 30.6 32.4 30.8 32.1 RDW ARET PLT WBC % xlO^ / h x 1CT3/m L xlOA3/nL 11.8 11.7 11.7 10.6 13.2 11.7 11.6 11.2 11.5 11.7 11.7 12.6 12.8 12.9 NT 13.9 13.1 12.2 12.1 11.9 172 . 251. 209. 172. 273. 289. 278. 324. 172. 255. 248. 234. 204. 260. NT 309. 261. 307. 217. 226. 1111 1267 RNV RNV 1169 962 RNV 1231 1309 RNV 14.21 11.43 14.14 15.51 11.58 13.73 19.08 15.31 11.56 10.89 1215 RNV 1052 1428 NT 1334 RNV RNV 1427 RNV 11.78 15.41 11.79 18.31 NT 16.90 14.29 14.43 14.47 13.28 Company Sanitized. Does not contain TSCA CBI - 675 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number ANEU xlO A3/*lL ANPR xlOA3/nL ALYM x IO^/mL Individual Hematology Values AMON AEOS ABAS ALUC xlQA3/iiL x 1(T3/m L xl0~3/L xl0A3/iiL ABLT x 10a 3/m L Female, Group: II - 0 mg/kg - Day 40 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 0.95 0.75 0.65 0.65 1.29 0.72 1.39 2.19 1.54 1.05 NT 6.19 NT 9.93 NT 8.53 NT 10.14 NT 5.85 NT 9.81 NT 13.83 NT 11.32 NT 7.40 NT 7.18 Female, Group: IV - 25i mg/kg - Day 40 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 1.75 2.18 1.29 2.22 1.15 1.09 1.75 3.04 1.51 1.61 NT 13.70 NT 7.65 NT 7.56 NT 12.97 NT 7.60 NT 11.57 NT 9.42 NT 13.67 NT 13.73 NT 7.62 0.12 0.17 0.20 0.35 0.29 0.39 0.27 0.30 0.15 0.37 0.54 0.18 0.28 0.44 0.41 0.28 0.54 0.67 0.44 0.17 0.04 0.03 0.13 0.10 0.07 0.17 0.09 0.12 0.08 0.24 0.08 0.08 0.07 0.16 0.11 0.21 0.07 0.31 0.13 0.08 0.06 0.05 0.13 0.06 0.10 0.08 0.16 0.17 0.11 0.09 0.14 0.11 0.11 0.10 0.10 0.13 0.08 0.18 0.18 0.07 0.06 0.10 0.37 0.13 0.12 0.10 0.20 0.20 0.32 0.12 0.24 0.11 0.12 0.24 0.13 0.16 0.20 0.15 0.19 0.09 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT AMSC '3/m L NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT DuPont-5990 Company Sanitized. Does not contain TSCA CBI -676- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number ANEU xlC,3//iL ANPR ALYM xlO'3/ixh x I O ^ / mL Individual Hematology Values AMON x 1CT3/mL AEOS x 10~3/mL ABAS X1CT3/ML ALUC x 10~3/mL ABLT xlO'N3/^L AMSC x 10~ 3/mL Female, Group: VI - 100 mg/kg - Day 40 646501 0.79 NT 12.75 0.37 0.08 0.08 0.14 NT NT 646505 1.71 NT 8.78 0.40 0.17 0.22 0.16 NT NT 646510 1.09 NT 12.45 0.25 0.06 0.14 0.15 NT NT 646534 1.64 NT 12.66 0.51 0.21 0.21 0.28 NT NT 646556 1.17 NT 9.43 0.51 0.17 0.16 0.15 NT NT 646578 1.46 NT 11.48 0.39 0.08 0.13 0.18 NT NT 646608 2.80 NT 15.40 0.33 0.11 0.19 0.24 NT NT 646624 2.44 NT 11.95 0.33 0.13 0.24 0.22 NT NT 646629 1.10 NT 9.89 0.26 0.09 0.11 0.12 NT NT 646633 0.90 NT 9.32 0.29 0.21 0.05 0.11 NT NT Female, Group: VIII - 500 mg/kg - Day 40 646509 1.47 NT 9.68 0.36 0..08 0 .09 0 .10 NT NT 646535 1.16 NT 13.43 0.37 0..20 0 .09 0 .16 NT NT 646536 1.53 NT 9.39 0.44 0..20 0 .09 0 .14 NT NT 646577 1.69 NT 15.78 0.33 0,.12 0 .15 0 .25 NT NT 646593 NT NT NT NT NT NT NT NT NT 646609 1.28 NT 14.82 0.38 0..11 0 .08 0..24 NT NT 646610 1.41 NT 12.04 0.49 0..12 0 .10 0 .13 NT NT 646614 1.57 NT 11.99 0.48 0..07 0 .12 0..20 NT NT 646657 .1.22 NT 12.27 0.37 0 .12 0 .22 0..28 NT NT 646669 0.83 NT 11.72 0.29 0 .08 0 .13 0 .22 NT NT DuPont-5990 Company Sanitized. Does not contain TSCA CBI -677- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number COND RBC xl0"6/yL HGB g/dL Female, Group: II - 0 mg/kg - Day 96 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 OK 7.63 14.4 OK 6.13 13.3 OK 8.46 15.4 OK 8.22 15.4 OK 7.64 14.9 OK 8.31 15.3 OK 8.30 15.7 OK 8.52 15.5 OK 7.31 14.0 OK 8.60 16.1 Female, Group: IV - 25i mg/kg - Day 96 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 OK OK OK CLOT OK OK OK OK OK OK 8.11 7.87 7.12 NT 7.33 7.83 7.64 8.22 7.47 7.37 14.3 14.8 13.9 NT 13.7 15.5 13.9 15.4 14.9 14.3 Individual Hematology Values HCT MCV MCH MCHC % fL pg g/dL 43.0 39.5 45.7 44.9 43.9 46.0 47.3 46.0 41.4 48.0 43.2 44.8 41.8 NT 41.3 45.9 42.3 45.9 44.6 42.4 56.3 64.4 54.1 54.6 57.4 55.4 57.0 54.0 56.6 55.7 53.2 56.9 58.7 NT 56.4 58.5 55.4 55.9 59.7 57.5 18.9 21.7 18.3 18.7 19.5 18.4 19.0 18.2 19.1 18.7 17.6 18.8 19.5 NT 18.7 19.8 18.2 18.8 19.9 19.4 33..6 33..8 33..8 34 .3 33..9 33 .2 33 .3 33 .7 33 .8 33 .5 33.2 33.0 33.2 NT 33.1 33.7 32.9 33.6 33.3 33.7 RDW ARET PLT WBC % x 1(T3/m L xlO'-l/L x 10~3/m L 10..6 14..2 11..6 12 .0 11..1 11 .2 12 .0 11 .2 11 .3 12 .2 11.4 11.7 11.8 NT 12.3 12.0 12.4 11.9 11.1 11.9 175. 213 . 130. 153 . 154. 148. 189. 182. 179. 160. 124. 170. 188. NT 165. 182. 158. 165. 152. 212. 1078 122 1067 1066 961 896 ENV RNV 1137 RNV 7 .,83 8..23 7.,94 11..27 7 .87 9..84 10..60 10..21 7..55 8..40 1383 1103 1074 NT RNV 1166 1049 RNV 897 985 16.59 11.10 9.73 NT 6.93 13.77 7.76 9.50 9.37 6.38 Company Sanitized. Does not contain TSCA CSI -678 - )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________ ) DuPont-5990 Animal Number COND RBC xlOn6/h HGB g/dL Female, Group: VI - 100 mg/kg - Day 96 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 OK 6.30 11.5 OK 6.93 12.7 OK 6.86 13.5 OK 7.65 13.9 OK 6.60 12.3 OK 7.42 14.5 OK 7.49 14.4 OK 7.60 14.1 OK 7.45 13.9 OK 7.68 14.3 Female, Group: VIII - 500 mg/kg - Day 96 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 OK 6.67 12.3 OK 7.29 12.7 OK 6.65 12.0 OK 7.39 12.8 OK 7.13 12.9 OK 7.33 13.5 OK 7.98 14.7 OK 6.99 13.1 OK 5.68 10.3 OK 7.16 12.4 Individual Hematology Values HCT MCV MCH MCHC % fL pg g/dL 34.9 39.2 40.6 40.0 37.5 43.8 42.6 43.0 41.9 42.0 37.7 38.4 37.1 38.9 40.4 41.6 44.5 39.3 31.5 37.8 55.5 56.6 59.2 52.2 56.8 59.0 57.0 56.6 56.2 54.6 56.4 52.7 55.8 52.6 56.6 56.7 55.7 56.2 55.4 52.8 18.3 18.4 19.7 18.2 18.7 19.5 19.2 18.5 18.6 18.6 18.4 17.4 18.0 17.3 18.2 18.4 18.4 18.7 18.1 17.3 33.0 32.5 33.4 34.8 32.9 33.1 33.8 32.7 33.1 34.1 32.6 33.0 32.3 33.0 32.1 32.5 33.0 33.4 32.6 32.7 RDW ARET PLT WBC % xlOA3//xL xlOA3/b xlOA3/L 13.7 12.7 13.0 11.8 15.0 12.5 12.5 12.2 13.3 12.5 13.1 14.7 16.5 14.5 14.6 15.6 14.5 13.0 15.4 13.2 182. 171. 180. 118. 199. 238. 188. 224. 197. 174. 226. 234. 271. 171. 268. 275. 250. 175. 221. 160. 1164 1312 1484 972 1210 964 RNV 1059 1274 RNV 10.65 10.98 9.90 9.75 8.63 12.23 12.23 10.25 8.55 6.98 1103 1379 RNV RNV RNV RNV 1183 1285 1514 1489 8.72 11.86 7.10 12.65 11.15 11.25 11.51 9.56 11.65 9.98 Company Sanitized. Does not contain TSCA CBI - 679- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Hematology Values Animal ANEU ANPR ALYM AMON AEOS ABAS ALUC ABLT AMSC Number xl0"3/aL xl0~3/nL x 10"3/mL x I O ^ / mL x 10~ 3/mL x 10~3/mL x 10~3/mL x I O ^ / mL x 10" 3/mL Female, Group: II - 0 mg/kg - Day 96 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 1..05 0..78 0..68 0..79 1.,17 0..72 0..99 0..93 1..60 1,,17 NT NT NT 0 .00 NT NT NT NT NT NT 6..20 7 .05 6,.71 9..47 6,.11 8,,44 9..17 8..61 5,.36 6..51 Female, Group : IV - 25 mg/kg - Day 96 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 2,.23 1..63 1..97 NT 0..79 1..21 1..26 1..80 1..02 0. 65 NT 12..88 NT 8,.90 NT 7..19 NT NT NT 5..52 NT 11.,47 NT 5..78 NT 7.,01 NT 7..88 NT 5.,19 0..26 0..15 0..21 0.,79 0..25 0..24 0..12 0..30 0..25 0..28 0..92 0,.23 0..31 NT 0..31 0..53 0..37 0..30 0..15 0..22 0..05 0..03 0..14 0..11 0..08 0..17 0,.07 0..10 0..07 0 .22 0 .14 0 .15 0 .07 NT 0..07 0..20 0 .11 0 .11 0 .12 0 .05 0.,14 0..07 0..04 0..11 0..12 0..16 0..11 0..15 0..08 0..07 0,.18 0..10 0 .07 NT 0..08 0..16 0..11 0..17 0..10 0..11 0..13 0..16 0..15 0..00 0..13 0..11 0,.13 0..11 0..18 0,.16 0 .25 0 .10 0 .13 NT 0,.15 0..21 0,.13 0..10 0..09 0,.16 NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT DuPont-5990 Company Sanitized. Does not contain TSCA CBI -680- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number ANEU xlCia 3/m L ANPR x !0a 3/m L ALYM x!0A3/L Individual Hematology Values AMON AEOS ABAS ALUC ABLT xlOA3/(ih x 10a 3/m L x 10a 3/m L x 10a 3/m L. xlOA3/L AMSC xIO^/mL Female, Group: VI - 100 mg/kg - Day 96 646501 1.20 NT 8.75 0.34 0.08 0.05 0.22 NT NT 646505 2.10 NT 7.87 0.44 0.25 0.08 0.23 NT NT 646510 0.51 NT 8.81 0.23 0.06 0.16 0.13 NT NT 646534 1.57 NT 7.50 0.36 0.13 0.03 0.17 NT NT 646556 1.07 NT 6.91 0.33 0.12 0.07 0.13 NT NT 646578 1.00 NT 10.57 0.25 0.06 0.12 0.25 NT NT 646608 1.41 NT 10.22 0.27 0.12 0.07 0.15 NT NT 646624 0.89 NT 8.57 0.31 0.16 0.11 0.22 NT NT 646629 0.62 NT 7.30 0.19 0.20 0.05 0.19 NT NT 646633 1.31 NT 5.23 0.16 0.17 0.03 0.08 NT NT Female, Group: VIII - 500 mg/kg - Day 96 646509 1.24 NT 6.93 0.26 0 .05 0..09 0,.16 NT NT 646535 1.30 NT 10.00 0.19 0 .12 0..11 0..13 NT NT 646536 0.54 NT 6.08 0.17 0 .15 0..04 0,.12 NT NT 646577 0.80 NT 11.01 0.30 0 .20 0,.07 0..27 NT NT 646593 0.96 NT 9.57 0.27 0..09 0..08 0..19 NT NT 646609 1.40 NT 9.20 0.28 0..11 0..10 0..16 NT NT 646610 2.10 NT 8.60 0.38 0,.22 0..11 0..11 NT NT 646614 1.01 NT 7.87 0.23 0..12 0..09 0..23 NT NT 646657 2.04 NT 8.82 0.35 0..16 0..02 0..25 NT NT 646669 0.81 NT 8.60 0.29 0..10 0.,06 0,.12 NT NT DuPont-5990 Company Sanitized. Does not contain TSCA CBI -681 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number COND RBC x 1Q^6/m L HGB g/dL Female, Group: II - 0 mg /kg - Day 124 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 OK 7.94 14.7 OK 7.65 14.3 OK 8.07 14.9 OK 8.87 15.9 OK 8.93 15.9 OK 8.30 15.7 OK 7.94 14.7 OK 8.30 15.9 OK 8.10 15.2 OK 7.61 14.0 Female, Group: VIII - 500 mg/kg - Day 124 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 OK 8.74 15.9 OK 7.40 13.8 OK 8.05 14.9 OK 8.22 14.9 OK 7.41 13.4 OK 7.42 13.8 OK 8.00 14.2 OK 8.49 15.0 OK 7.89 15.1 OK 8.75 16.0 Individual Hematology Values HOT MCV MCH MCHC % fL p g g/dL 43.3 43.5 45.2 48.3 47.8 48.4 43.9 51.0 46.2 42.4 46.8 40.5 45.2 46.8 40.7 41.2 43.1 46.6 46.6 47.9 54.5 56.9 56.0 54.5 53.5 58.4 55.4 61.4 57.1 55.7 53.5 54.8 56.2 56.9 55.0 55.5 53.9 54.9 59.1 54.8 18.6 18.8 18.4 17.9 17.8 18.9 18.5 19.2 18.7 18.4 18.2 18.7 18.5 18.1 18.0 18.6 17.7 17.7 19.2 18.3 34.1 32.9 32.9 32.9 33.3 32.4 33.4 31.3 32.8 33.1 34.0 34.1 32.9 31.8 32.8 33.4 32.9 32.3 32.5 33.3 RDW ARET PLT WBC % x 10~3/m L xlO*3/L xl0"3/h 11.7 12.3 12.0 12.7 12.1 12.0 12.1 11.3 12.0 12.0 11.8 13.7 13.4 13.2 12.8 14.5 12.4 12.8 13.2 12.3 137. 130. 170. 183. 188. 204. 140. 166. 187. 139. 131. 154. 124. 185. 137. 152. 114. 187. 176. 115. RNV RNV 980 RNV 1242 789 839 RNV 812 RNV 11.09 7.80 9.86 8.77 13.29 9.91 6.13 5.54 6.50 7.92 RNV 842 752 1181 1151 1157 RNV 1068 RNV RNV 6.93 10.00 9.85 5.33 9.55 5.72 5.28 6.55 7.48 7.57 Company Sanitized. Does not contain TSCA CBI -682- )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-5990 Animal ANEU ANPR Number xlOA3/aL x 10a3/mL Individual Hematology Values ALYM AMON AEOS ABAS ALUC x 10a 3/mL x 10a 3/mL x 10a 3/mL x 10a 3/mL x ! 0a 3/mL ABLT x 10a 3/mL AMSC xlOA3//xL Female, Group: II - 0 mg/kg - Day 124 646511 1..41 NT 9..07 0..31 0..08 0..12 0.,10 NT NT 646549 1..59 NT 5..77 0..21 0..15 0.,04 0..04 NT NT 646551 0..60 NT 8.,82 0..19 0,.06 0.,10 0..09 NT NT 646565 0..99 NT 7.,29 0..28 0..11 0..05 0..05 NT NT 646580 1..56 NT 10..99 0..27 0..12 0..28 0..08 NT NT 646581 0 .76 NT 8,,77 0,.18 0,.04 0..07 0..10 NT NT 646586 1..31 NT 4..51 0..15 0..04 0..06 0,.05 NT NT 646613 1 .09 NT 4..17 0,.10 0 .08 0..09 0..02 NT NT 646627 0..83 NT 5..23 0..18 0..07 0..13 0..06 NT NT 646652 1..34 NT 6..10 0,.21 0 .17 0..03 0..07 NT NT lale, Group: VIII - 500 mg/kg - Day 124 646506 2..10 NT 4..56 0..10 0 .11 0..02 0..04 NT NT 646508 1 .54 NT 7..81 0..33 0 .11 0..10 0 .11 NT NT 646540 1 .12 NT 8..08 0..40 0 .09 0..05 0..11 NT NT 646542 0 .74 NT 4..22 0..16 0 .06 0..09 0,.06 NT NT 646545 2 .07 NT 6..68 0,.45 0 .09 0..15 0..11 NT NT 646548 0..71 NT 4 .66 0..20 0..07 0..04 0..05 NT NT 646599 0..71 NT 4..27 0..11 0..08 0..06 0..04 NT NT 646618 0,.92 NT 5..36 0..10 0 .04 0..08 0,.05 NT NT 646637 1..22 NT 5..78 0..22 0 .12 0..08 0..06 NT NT 646650 2..01 NT 5 .10 0..18 0..16 0..07 0..04 NT NT Company Sanitized. Does not contain TSCA CBI -683 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Animal Number COND RBC x 10~6/m L HGB g/dL Female, Group: II - 0 mg/kg - Day 183 646507 646530 646588 646597 CLOT OK OK OK NT 8.16 7.84 7.98 NT 14.9 15.6 15.3 Female, Group: IV - 25 mg/kg - Day 183 646531 646568 646625 646626 646636 OK OK CLOT OK OK 8.30 7.36 NT '7.97 8.25 15.7 14.6 NT 15.7 16.0 Female/ Group: VI - 100 mg/kg - Day 183 646533 646630 646632 646634 646656 CLOT CLOT OK OK CLOT NT NT 8.16 7.62 NT NT NT 14.4 14.3 NT Female, Group: VIII - 500 mg/kg - Day 183 646523 646528 646601 646620 646667 OK OK CLOT CLOT OK 7.95 8.35 NT NT 7.87 14.0 15.4 NT NT 15.3 Individual Hematology Values HCT MCV MCH MCHC % fL p g g/dL NT 44.4 44.8 44.8 46.6 43.8 NT 47.4 47.4 NT NT 43.2 42.1 NT 42.6 46.2 NT NT 45.3 NT 54.4 57.1 56.2 56.2 59.5 NT 59.5 57.4 NT NT 53.0 55.2 NT 53.6 55.3 NT NT 57.6 NT 18.3 19.9 19.2 18.9 19.8 NT 19.7 19.4 NT NT 17.6 18.8 NT 17.6 18.4 NT NT 19.4 NT 33.6 34.8 34.1 33.7 33.3 NT 33.1 33.8 NT NT 33.3 34.0 NT 32.9 33.4 NT NT 33.8 RDW ARET PLT WBC % x 10^3/m L x.lOn3/h x 10~3/m L NT 11.7 12.4 13.3 11.5 13.1 NT 11.9 12.1 NT NT 12.2 11.9 NT 12.7 11.9 NT NT 12.8 NT 155. 182. 130. 155. 172. NT 158. 135. NT NT 136. 167. NT 150. 165. NT NT 186. NT 951 1211 1091 NT 8.31 8.64 7.47 RNV 8.36 RNV 7.54 NT NT 937 6.66 903 5.94 NT NT 1330 1285 NT NT NT 4.76 8.19 NT RNV 1708 NT NT RNV 6.27 12.02 NT NT 8.21 Company Sanitized. Does not contain TSCA CBI -684- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Animal Number ANEU xlCr3/ML ALYM x 10^3/m L AMON x 10^3/m L Individual Hematology Values AEOS ABAS ALUC ABLT x 10*3/L x 10a 3/m L xlO~3/aL xl0/v3/L AHSN xlOA3/^L ABAN x 10a 3/m L AMET x!0^3/iiL AMYE x !0^3/m L Female, Group: II - 0 mg/kg - Day 183 646507 646530 646588 646597 NT 1.87 1.78 1.09 NT 5.97 6.26 5.80 NT 0.20 0.24 0.23 Female, Group: IV - 25i mg/kg - Day 183 646531 646568 646625 646626 646636 1.00 1.74 NT 1.31 0.86 6.95 5.19 NT 4.82 4.68 0.13 0.22 NT 0.24 0.14 Female, Group: VI - 100 mg/kg - Day 183 646533 646630 646632 646634 646656 NT NT 0.90 2.04 NT NT NT 3.62 5.69 NT NT NT 0.19 0.17 NT Female, Group: VIII - 500 mg/kg - Day 183 646523 646528 646601 646620 646667 2.23 1.66 NT NT 1.97 3.68 9.57 NT NT 5.54 0.16 0.32 NT NT 0.29 NT 0.17 0.10 0.21 0.08 0.14 NT 0.07 0.14 NT NT 0.05 0.13 NT 0.13 0.14 NT NT 0.16 NT 0.03 0.15 0.06 0.13 0.13 NT 0.07 0.04 NT NT 0.00 0.05 NT 0.03 0.19 NT NT 0.09 NT 0.07 0.12 0.08 0.07 0.12 NT 0.14 0.08 NT NT 0.00 0.11 NT 0.05 0.12 NT NT 0.16 NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT Company Sanitized. Does not contain TSCA CBI -685 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number APRO xlC>*3//iL AMYB xl0A3/iiL ARL xlO^i/h Individual Hematology Values AAL AIL ACL ABLB xlOA3/j*L xlO^ / L x l O ^ / M L x 10~3/m L AIE xlO^l/L AIM xlO*!/L APLA xlO Female, Group: ii - 0 mg/kg - Day 183 646507 NT NT NT 646530 NT NT NT 646588 NT NT NT 646597 NT NT NT Female, Group: IV - 251 mg/kg - Day 183 646531 NT NT NT 646568 NT NT NT 646625 NT NT NT 646626 NT NT NT 646636 NT NT NT Female, Group: VI - 100 mg/kg - Day 183 646533 646630 646632 646634 646656 NT NT 0 .00 NT NT NT NT 0.00 NT NT NT NT 0.00 NT NT Female, Group: VIII - 500 mg/kg - Day 183 646523 NT NT NT 646528 NT NT NT 646601 NT NT NT 646620 NT NT NT 646667 NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT Company Sanitized. Does not contain TSCA CBI - 686- ))) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-5990 Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: I 0 mg/kg - Day 39 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 Male, Group: III 25 mg/kg - Day 39 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 1 1 -1 1 -1 -1 -2 1 -2 -- 1 1 1 2 1 2 1 1 1 21 1 3 1 1 2 1 2 2 1 2 2 2 1 ACAN 1 1 1 2 1 1 1 1 1 1 1 TARG RX HJB Company Sanitized. Does not contain TSCA C8I -687 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: V - 100 mg/kg - Day 39 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 Male, Group: VII - 500 mg/kg - Day 39 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 12 12 13 1 11 13 2 13 22 12 1 1o 12 1 13 11 22 11 21 23 ACAN 1 1 1 1 2 1 1 -1 1 1 11 1 1 1 1 1 2 TARG --- __ __ -- --- __ --- __ --- DuPont-5990 RX HJB -- --- _ _ -- __ _ _ --- _ _ -- 1 -- --- -- __ __ __ -- --- --- -- Company Sanitized. Does not contain TSCA CBI -688 - ))) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________________ DuPont-5990 Animal Number SPEC Male, Group: I - 0 mg/kg - Day 39 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 Male, Group: III - 25 mg/kg - Day 39 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 Individual Red Blood Cell Morphology Values Company Sanitized. Does not contain TSCA CBI -689- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number SPEC Male, Group: V - 100 mg/kg - Day 39 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 Male, Group: VII - 500 mg/kg - Day 39 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 Individual Red Blood Cell Morphology Values ) DuPont-5990 Compny Sanitized. Does not contain TSCA CBI -690- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: I - 0 mg/kg - Day 95 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 NORMAL Male, Group: III - 25 mg/kg - Day 95 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 NORMAL 1 -- 2-- 2 __ 2 -- 1 __ 3 1 -- 2 -3 -2 2 3 -1 1 1 -- 2 3 3 2 2 2 1 2 3 2 2 2 3 1 ACAN 1 2 1 2 1 1 2 1 1 2 1 11 1 1 3 1 TARG --- . __ ---- __ --- DuPont-5990 RX HJB --- ---- --- -- -- 1 -- -_ _ --- --- -- Company Sanitized. Does not contain TSCA CBI -691 - )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________________DuPont-5990 Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: V - 100 mg/kg - Day 95 646349 -- 1 646373 -- -- 646385 -- -- 646435 -- -- 646455 -- _ _ 646456 646463 --- 1 646469 -- -- 646472 -- -- 646488 -- Le, Group: VII - 500 mg/kg - Day 95 1 ----- 1 __ __ -- ----- __ ----- -- 2 -2 -3 -- 2 __ 2 -2 -2 -- 1 -- 2 -- 3 -- 4 2 2 2 3 3 3 3 3 3 646343 __ 646346 -- 1 1 -- 646347 -- 1 1 -- 646388 -- 2 2 -- 646407 -- -- -- -- 646413 -- 1 1 -- 646433 -- -- -- -- 646437 -- -- 646442 -- -- 646475 -- 1 1 -- 221 3 -- 3 2 -- 1 2-- 3 -- -- 3 322 3 -- 2 2 __ -- 312 324 ACAN 2 1 2 1 2 2 2 2 1 2 2 2 1 2 2 3 2 2 1 3 TARG --- __ --- --- -- _ ---__ -__ --- RX HJB -- --- --- --- -- __ __ -_ _ -- --- --- -- -- __ -- -- -- __ - - __ -- __ -- __ Company Sanitized. Does not contain TSCA CBI -692- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number SPEC Male, Group: I - 0 mg/kg - Day 95 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 1-SPHEROCYTE Male, Group: III - 25 mg/kg - Day 95 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 Individual Red Blood Cell Morphology Values DuPont-5990 Company Sanitized. Does not contain TSCA CBI -693- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________________________ Animal Number SPEC Male, Group: V - 100 mg/kg - Day 95 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 1-SPHEROCYTE 1 -SPHEROCYTE 1-SPHEROCYTE 1-SPHEROCYTE 1-SPHEROCYTE Male, Group: VII - 500 mg/kg - Day 95 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 1-SPHEROCYTE 2 -SPHEROCYTE 1-SPHEROCYTE Individual Red Blood Cell Morphology Values ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -694- ))) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-5990 Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: I 0 mg/kg - Day 123 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 Male, Group: VII - 500 mg/kg - Day 123 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 --- -- ----- __ - -- 2 __ ---- 1 -- 11 -- ~~ 21 --- 1 __ --- 1 1 -- 1 - -- 1 -- 1 1 __ 1 -1 __ i i i i 2 2 1 1 1 2 2 1 2 1 1 2 2 -- 2 2 1 2 1 1 1 1 ACAN 1 1 1 1 -- 1 2 2 4 3 2 4 4 1 3 3 4 TARG RX HJB 1 Company Sanitized. Does not contain TSCA CBI -695- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number SPEC Male, Group: I - 0 mg/kg - Day 123 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 Male, Group: VII - 500 mg/kg - Day 123 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 Individual Red Blood Cell Morphology Values DuPont-5990 Company Sanitized. Does not contain TSCA CBI -696- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI ACAN Male, Group: i - 0 mg/kg - Day 183 646325 NO -646396 NO -646468 NO -646495 -- -- ---- -- Male, Group: h i - 25 mg/kg - Day 183 646368 646436 646438 646449 646453 NO NO -NO -- NO ' -NO __ --~~ Male, Group: V - 100 mg/kg - Day 183 646327 646335 646376 646403 NO TRACE TRACE NO TRACE TRACE NO -- -NO -- -- Male, Group: VII - 500 mg/kg - Day 183 646344 646355 646361 646391 646466 NO __ __ NO -- -NO TRACE TRACE _ _ -- -NO -- _ _ __ TRACE -- TRACE -- TRACE -- -- TRACE -- TRACE -- TRACE _ _ TRACE -- TRACE -- TRACE TRACE -- TRACE -- TRACE __ TRACE -- TRACE -- TRACE -- --- TRACE __ TRACE FEW -- TRACE MODERATE -- -- TRACE -- -- -- TRACE FEW TRACE MODERATE -- TRACE TRACE -- MODERATE FEW MODERATE FEW __ FEW FEW -- FEW MODERATE -- FEW FEW -- FEW FEW __ TRACE FEW -- TRACE TRACE -- MODERATE MODERATE -- -- _ _ -- -- TRACE TARG __ ---- __ __ -__ --__ -- __ -- __ -- ) DuPont-5990 RX HJB __ --- ----__ __ -- Company Sanitized. Does not contain TSCA CBI -697- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number SPEC Individual Red Blood Cell Morphology Values Male, Group: I - 0 mg/kg - Day 183 646325 646396 646468 646495 Male, Group: III - 25 mg/kg - Day 183 646368 646436 646438 646449 646453 TRACE-POIKILOCYTOSIS Male, Group: V - 100 mg/kg - Day 183 646327 646335 646376 646403 TRACE-SPHEROCYTE;TRACE-POIKILOCYTOSIS Male, Group: VII - 500 mg/kg - Day 183 646344 646355 646361 646391 646466 TRACE-POIKILOCYTOSIS DuPont-5990 Company Sanitized. Does not contain TSCA CBI -698- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________ ) DuPont-5990 Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: II - 0 mg/kg - Day 40 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 ---------- 1 -- - --__ Female, Group: IV - 25 mg/kg - Day 40 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 ------ ---- 2- - - 1 2 -- -- -- -- 1- - - 2- - - 1- - - 1- - - 1- - - 1- - - 1- - - - -- 2 2 1 2 1 2 2 -- 3 - -- 2 1 -- 3 1 -- -- 1 -- 2 2 -- 2 2 -- 3 11 1 -11 3 12 ACAN __ 1 --- 1 1 1 1 1 1 1 1 1 2 1 1 1 TARG RX HJB 1 Company Sanitized. Does not contain TSCA CBI -699- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ ) DuPont-5990 Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: VI - 100 mg/kg - Day 40 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 Female, Group: VIII - 500 mg/kg - Day 40 646509 646535 646536 646577 646609 646610 646614 646657 646669 2 __ 2 __ 2 -1 __ 2 -2 -2 __ 1 -2 -2 -- 3 2 2 1 3 1 3 -- 3 1 1 2 -1 -2 -2 -2 -11 2 -2 __ 1 2 2 3 1 2 11 3 2 ACAN 2 -- 1 -- 2 1 1 1 1 1 1 1 2 1 1 1 TARG ---- --- RX HJB __ -- --- -__ -- _ _ -- -- -- Company Sanitized. Does not contain TSCA CBI -700- )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-5990 Animal Number SPEC Female, Group: II - 0 mg/kg - Day 40 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 Female, Group: IV - 25 mg/kg - Day 40 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 Individual Red Blood Cell Morphology Values Company Sanitized. Does not contain TSCA CBI -701 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number SPEC Individual Red Blood Cell Morphology Values Female, Group: VI - 100 mg/kg - Day 40 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 1-SPHEROCYTE Female, Group: VIII - 500 mg/kg - Day 40 646509 646535 646536 646577 646609 646610 646614 646657 646669 1-SPHEROCYTE 1-SPHEROCYTE 1-SPHEROCYTE 1-SPHEROCYTE DuPont-5990 Company Sanitized. Does not contain TSCA CBI -702- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: II - 0 mg/kg - Day 96 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 NORMAL NORMAL ---- NORMAL 2 ---- Female, Group: IV - 25 mg/kg - Day 96 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 NORMAL 1 ---- 1 ---- 3 1 1 1 1 -11 1 1 1 -1 2 1 2 2 ACAN 1 TARG DuPont-5990 RX HJB Company Sanitized. Does not contain TSCA CBI -703 - )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________________ Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: VI - 100 mg/kg - Day 96 646501 -- __ 646505 646510 -- __ __ __ 646534 -- __ 646556 -- -- 646578 -- __ 646608 -- -- 646624 -- 646629 __ 646633 Female, Group: VIII - 500 mg/kg - Day 96 646509 __ __ 646535 -- -- 646536 -- -- 646577 -- -- 646593 __ -- 646609 __ - - 646610 -- -- 646614 646657 --- -- __ 646669 -- -- -- 2 2 i -- 1 -- 2 21 -- --- 2 1 2 3 -- 2 -- -- -- 2 -- 3 -- 2 2 -- 1 2 2 -- __ 2 3 2 1 2 1 1 2 3 -- 2 -- 2 -- 3 1 2 -- 2 1 2 -- 2 -- 2-- 2 2 -- 2 2 2 -- 2 1 2 ACAN 2 2 -- 2 -- 1 -- 2 1 3 2 3 2 1 1 -- 3 2 TARG -- __ -- _ ---- ------ __ ) DuPont-5990 RX HJB __ ---- -- -__ -- __ __ -- - __ -- -- - __ __ -- - __ -- --- -- Company Sanitized. Does not contain TSCA CBI -704- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number SPEC Female, Group: II - 0 mg/kg - Day 96 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 Female, Group: IV - 25 mg/kg - Day 96 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 Individual Red Blood Cell Morphology Values DuPont-5990 Company Sanitized. Does not contain TSCA CBI -705- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number SPEC Individual Red Blood Cell Morphology Values Female, Group: VI - 100 mg/kg - Day 96 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 1-NUCLEATED RED BLOOD CELL 1-SPHEROCYTE Female, Group: VIII - 500 mg/kg - Day 96 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 1 -SPHEROCYTE DuPont-5990 Company Sanitized. Does not contain TSCA CBI -706- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: II - 0 mg/kg - Day 124 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 Female, Group: VIII - 500 mg/kg - Day 124 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 1 1 -1 2 -1 -2 -1 2 -2 -2 2 1 1 2 2 1 1 2 1 2 2 2 2 1 1 2 3 2 1 2 2 2 2 2 3 ACAN 1 2 1 1 1 2 1 2 1 2 2 1 TARG DuPont-5990 RX HJB Company Sanitized. Does not contain TSCA CBI -707- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number SPEC Individual Red Blood Cell Morphology Values Female, Group: II - 0 mg/kg - Day 124 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 Female, Group: VIII - 500 mg/kg - Day 124 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 DuPont-5990 Company Sanitized. Does not contain TSCA CBI -708 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) > _________________________________________ DuPont-5990 Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: II - 0 mg/kg - Day 183 646507 646530 646588 NO NO -_-_ 646597 NO -- Female, Group: IV - 25i mg/kg - Day 183 646531 646568 646625 646626 646636 NO __ NO TRACE NO TRACE NO Female, Group: VI - 100 mg/kg - Day 183 646533 646630 646632 NO -646634 NO -646656 Female, Group: VIII - 500 mg/kg - Day 183 646523 646528 NO NO __ __ 646601 646620 646667 NO __ __ TRACE -- TRACE TRACE TRACE TRACE -- TRACE TRACE TRACE TRACE -- TRACE -- TRACE TRACE - - TRACE - - TRACE -- FEW -- FEW -- FEW TRACE -- FEW __ -- -- FEW -- --- FEW MODERATE - - MODERATE __ FEW ACAN TRACE TRACE TRACE __ TRACE -- TRACE TRACE TRACE FEW -- TRACE TARG ---- --- __ -- --- __ -- -- RX HJB -- --- --- -- -- --- --- --- -- --- -- __ __ - - -- Company Sanitized. Does not contain TSCA CBI -709- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number SPEC Individual Red Blood Cell Morphology Values Female, Group: II - 0 mg/kg - Day 183 646507 646530 646588 646597 Female, Group: IV - 25 mg/kg - Day 183 646531 646568 646625 646626 646636 Female, Group: VI - 100 mg/kg - Day 183 646533 646630 646632 646634 646656 Female, Group: VIII - 500 mg/kg - Day 183 646523 646528 646601 646620 646667 DuPont-5990 Company Sanitized. Does not contain TSCA CBI -710- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PC GP BP Male, Group: I - 0 mg/kg - Day 39 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL ------ --- -- Male, Group: III - 25 mg/kg - Day 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL -- NORMAL NORMAL --------- 1 -- -1 -- -- SPEC ADEQ PLATELET ADEQ PLATELET Company Sanitized. Does not contain TSCA CBI -711 - >) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM T0X DB VC PC GP BP Male, Group: V - 100 mg/kg - Day 39 646349 NORMAL -- -- -- -- -- -- -- 646373 NORMAL __ -- -- -- -- -- -- 646385 NORMAL -- -- -- -- -- _ _ 646435 NORMAL -- -- -- -- - -- -- 646455 NORMAL -- -- -- -- -- 646456 -- -- -- -- -- __646463 NORMAL -- -- -- -- 1 -- -- 646469 __ -- -- -- __646472 NORMAL -- -- -- 1 -- -- - -- 646488 NORMAL -- -- -- -- -- -- -- Male, Group: VII - 500 mg/kg - Day 39 646343 646346 NORMAL NORMAL --- _-_- --- -- --- __ -- 646347 NORMAL -- -- -- -- 646388 646407 646413 646433 646437 NORMAL NORMAL NORMAL NORMAL NORMAL -- -, __ --- --- --- --- - __ --- __ __ --- __ -- -_-_ 646442 646475 -NORMAL --- __ -- 1 --- -- -- SPEC ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET Company Sanitized. Does not contain TSCA CBI -712- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PC GP BP Male, Group: I - 0 mg/kg - Day 95 546360 -- -- -- _ _ -- 1 -- 646367 NORMAL -- -- -- -- -- -- - 646374 -- -- -- -- _ _ 1 -- -- 646379 NORMAL -- __ __ -- -- -- _ _ 646420 NORMAL __ -- -- ~~ -- -- -- 646427 -- -- -- -- _ _ 1 __ -- 646482 -- -- _ _ -- -- 1 __ -- 646485 NORMAL -- -- -- -- -- -- 646489 -- -- -- -- -- 1 __ -- 646492 NORMAL -- -- -- -- -- -- -- Male, Group: III - 25 mg/kg - Day 95 646370 1 646399 NORMAL -- -- -- -- -- -- -- 646414 NORMAL -- -- -- -- 646421 NORMAL -- -- -- -- - 646423 NORMAL - -- -- -- -- -- - 646426 NORMAL -- __ -- -- -- -- -- 646443 -- _ _ -- -- -- 1 -- -- 646454 NORMAL -- __ -- -- -- -- 646458 NORMAL -- -- -- -- -- -- -- 646471 NORMAL -- -- -- -- -- -- -- SPEC ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET Company Sanitized. Does not contain TSCA CBI -713 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PC GP BP Male, Group: V - 100 mg/kg - Day 95 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 NORMAL NORMAL NORMAL -- NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL --------- -- Male, Group: VII - 500 mg/kg - Day 95 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL --- ---- -- -- --- __ __ __ -- -- -- __ ------ __ __ -- __ --- -- -- 1 1 1 SPEC ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET Company Sanitized. Does not contain TSCA CBI -714- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PC GP BP Male, Group: I - 0 mg/kg - Day 123 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 __ -- NORMA_L_ NORMA_L_ -- NORMAL NORMAL Male, Group: VII - 500 mg/kg - Day 123 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 __ NORMAL NORMAL NORMAL NORMA--L NORMAL NORMAL NORMAL __ __ 1 __ __ -- -- -- -- -- -- -- -- -- __ -- -- 1 -- -- -- --- --- -- -- -- 1 -- __ 1 __ --- --- __1 --- --- -- -- -- -- __ 1 -- -- -- -- -- -- __ -- -- -- -- -- __ -- -- -- -- -- 1 -- -- -- -- -- __ __ -- --- -- 1 -- __ - __ --- - - - - - SPEC ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET Company Sanitized. Does not contain TSCA CBI -715- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PCE GP BP Male, Group: I - 0 mg/kg - Day 183 646325 646396 646468 646495 YES YES YES -- Male, Group: III - 25 mg/kg - Day 183 646368 646436 646438 646449 646453 YES YES YES YES YES -- Male, Group: V - 100 mg/kg - Day 183 646327 646335 646376 646403 NO YES YES NO Male, Group: VII - 500 mg/kg - Day 183 646344 646355 646361 646391 646466 yes YES YE_S_ YES -- --- - __ __ __ -- --- __ -- - -- -- -- __ __ YES/UTD -- -- -- -- YES/ADEQ __ __ __ -- -- -- __ -- -- --- - SPEC DuPont-5990 Company Sanitized. Does not contain TSCA CBI -716- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PC GP BP Female, Group: II - 0 mg/kg - Day 40 646537 NORMAL -- -- -- -- -- 646538 646560 -NORMAL --- -- -- __ -- __ 1 -- --- --- 646592 646612 646617 646649 NORMAL NORMAL NORMAL NORMAL ----- --- __ --- __ __ --- --- __ -- -- __ --- ----- 646659 646665 NORMAL NORMAL --- - __ --- --- --- --- --- 646676 NORMAL -- -- -- -- -- -- -- Female, Group : IV - 25 mg/kg - Day 40 646502 646522 646567 646576 NORMA_L_ NORMAL NORMAL __ -- __ __ __ --- --- ---- 1 --- __ ---- __ -_-_ -- 646595 NORMAL -- -- - -- -- -- -- 646621 NORMAL -- -- 646635 NORMAL -- -- 646660 -- -- - - __- - - -- __ - - --- 1 -- --- ---- 646664 -- -- -- -- -- 1 -- -- 646673 NORMAL -- -- -- -- -- -- -- SPEC DECR PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET Company Sanitized. Does not contain TSCA CBI -717- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PC GP BP Female, Group: VI - 100 mg/kg - Day 40 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 NORMAL NORMAL NORMAL NORMAL -- NORMAL NORMAL -- --------- ------ __ ----- Female, Group: VIII - 500 mg/kg - Day 40 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 NORMAL -- NORMAL NORMAL -- NORMAL __ -- NORMAL -- ----- ----- -- --------__ -- --- ------- ---- ------- --- - - 1 -- -- - 1 -- -- __ -- - - 1 -- -- -_-_ - - 1 -- -- -- -- -- -- 1- - - - - - -- -- -- --- -- -- --- -- -- -- -- _ _ -- 1- - _ _ _ _ 1- - - - - - -- -- -- 1- - - - - - SPEC ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET Company Sanitized. Does not contain TSCA C8I -718- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PC GP BP Female, Group: II - 0 mg/kg - Day 96 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL ---------- -- --- - __ - - -- --- -- __ - - __ -- -- -- -- -- __ -- - -- -- -- __ -- -- -- __ 1- - _ _ 1 -- __ -- 1 -- __ ------- Female, Group : IV - 25 mg/kg - Day 95 646502 NORMAL __ -- __ __ 646522 NORMAL - -- -- -- -- -- 646567 NORMAL -- -- -- -- -- -- -- 646576 -- -- -- -- -- -- -- 646595 -- -- -- -- -- i -- 646621 646635 646660 NORMAL NORMAL -- __ -__- -- -- --- -- -- __- - _ _ -- 1 __ -- 646664 646673 NORMAL NORMAL --- --- --- -- _-_- --- --- SPEC ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET Company Sanitized. Does not contain TSCA CBI -719- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PC GP BP Female, Group: VI - 100 mg/kg - Day 96 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL -- NORMAL NORMAL -- ---------- -- Female, Group : VIII - 500 mg/kg 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 NORMAL NORMAL -- -- -- -- NORMAL NORMAL NORMAL NORMAL ---- __ ----- 1 -1-- --- 1 -- -1 -- -- 1 -- -1 -- -- SPEC ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET Company Sanitized. Does not contain TSCA CBI -720- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PC GP BP Female, Group: II - 0 mg/kg - Day 124 646511 -- -- 646549 -- -- 646551 NORMAL -- -- - -- 1 1 __ __ -- -- -_-_ 646565 -- -- -- -- 1 __ -- 646580 NORMAL -- -- -- __ -- -- -- 646581 646586 646613 NORMAL NORMAL -- --- __ ---- ---- -- __ __ --- 1 --- --- -- 646627 NORMAL -- -- -- -- -- -- -- 646652 -- -- -- -- 1 -- -- Female, Group : VIII - 500 mg/kg -- Day 124 646506 1 __ __ 646508 NORMAL - -- -- -- -- -- -- 646540 646542 NORMAL NORMAL --- -- -- -- -- -- -- --- --- --- 646545 NORMAL __ -- -- -- - - -- -- 646548 646599 646618 NORMAL -- NORMAL ---- --- - - - - - - - - - __ __-- -- 1 -- __ --- - - - -- 646637 -- -- -- -- -- 1 -- -- 646650 -- -- -- -- -- 1 - - -- SPEC ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET Company Sanitized. Does not contain TSCA CBI -721 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM TOX DB VC PCE GP BP Female, Group: II - 0 mg/kg - Day 183 646507 646530 646588 646597 YES YES YES Female, Group: IV - 25 mg/kg - Day 183 646531 646568 646625 646626 646636 NO NO YES YES YES/ADEQ YES/UTD Female, Group: VI - 100 mg/kg - Day 183 646533 646630 646632 646634 646656 YES YES Female, Group: VIII - 500 mg/kg - Day 183 646523 NO -- -- -- YES/UTD -- -- 646528 YES -- -- -- -- -- -- 646600 646620 - -- -- -- -- --- - __ --- --- --- 646667 NO -- -- -- -- YES/ADEQ -- -- SPEC DuPont-5990 Company Sanitized. Does not contain TSCA CBI -722- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number PHEM PLIP PICT Male, Group: I - 0 mg/kg - Day 95 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 NONE QNS NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: III - 25 mg/kg - Day 95 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Individual Coagulation PT APTT sec sec 14.9 NT 15.1 16.6 15.7 16.6 14.9 18.0 15.1 14.4 15.6 15.3 15.7 14.5 15.6 15.2 15.1 15.9 15.2 14.6 19.3 NT 19.9 21.6 18.6 21.4 23.6 21.9 17.8 17.2 22.2 17.0 19.0 17.2 18.3 19.2 17.6 20.4 20.3 14.4 Company Sanitized. Does not contain TSCA CBI -723 - Values ) DuPont-5990 ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number PHEM PLIP PICT Male, Group: V - 100 mg/kg - Day 95 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: VII - 500 mg/kg - Day 95 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE TRACE NONE NONE NONE NONE TRACE NONE NONE TRACE NONE Individual Coagulation PT APTT sec sec 14.5 14.2 13.9 16.5 14.4 14.3 14.7 15.0 14.7 15.8 14.2 13.4 16.3 14.8 15.2 15.3 15.9 15.9 17.2 13.8 19.0 17.7 13.7 14.8 16.3 16.5 19.2 14.8 18.2 15.0 14.1 17.0 14.5 18.3 15.8 15.7 18.2 12.6 15.4 14.1 Company Sanitized. Does not contain TSCA CBI -724- Values ) DuPont-5990 ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number PHEM PLIP PICT Male, Group: I - 0 mg/kg - Day 123 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: VII - 500 mg/kg - Day 123 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Individual Coagulation PT APTT sec sec 15.1 16.3 14.8 14.6 14.2 16.7 14.9 14.1 14.2 14.2 16.1 14.8 16.1 14.6 13.9 14.2 14.5 14.6 14.1 15.5 18.9 20.3 19.6 20.4 19.1 25.7 16.5 20.8 19.1 20.5 21.2 18.2 22.7 18.7 21.4 19.5 18.7 20.3 19.7 16.9 Company Sanitized. Does not contain TSCA C8I -725- Values ) DuPont-5990 )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-5990 Animal Number PHEM PLIP PICT Female, Group: II - 0 mg/kg - Day 96 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 NONE NONE NONE SMALL NONE TRACE NONE NONE TRACE NONE NONE NONE NONE TRACE NONE NONE NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: IV - 25 mg/kg - Day 96 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Individual Coagulation Values PT APTT sec sec 14.5 14.1 16.0 RNV 14.3 15.0 14.3 14.3 15.0 13.6 14.8 15.4 14.3 13.3 14.5 14.5 14.5 14.7 13.9 15.2 16.4 20.8 19.8 RNV 19.9 18.8 17.3 16.7 19.0 17.3 16.1 19.2 17.6 17.5 17.9 15.5 18.5 19.7 15.9 20.3 Company Sanitized. Does not contain TSCA CBI -726- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number PHEM PLIP PICT Female, Group: VI - 100 mg/kg - Day 96 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: VIII - 500 mg/kg - Day 96 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Individual Coagulation Values PT APTT sec sec 14.1 14.1 13.8 14.0 14.1 14.1 14.8 14.2 14.9 13.9 13.6 13.3 13.2 13.8 13.5 13.0 14.2 14.2 13.6 14.3 19.0 21.8 15.9 16.5 17.3 16.7 16.6 15.7 16.1 16.2 14.4 15.5 12.7 12.4 14.1 13.9 15.5 14.5 15.7 21.2 DuPont-5990 Company Sanitized. Does not contain TSCA CBI -727- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number PHEM PLIP PICT Female, Group: II - 0 mg/kg - Day 124 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: VIII - 500 mg/kg - Day 124 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Individual Coagulation Values PT . sec APTT sec 14.1 13.7 RNV 13.6 15.0 14.4 13.3 14.0 13.8 13.5 14.4 13.7 13.9 13.5 13.8 14.0 13.6 13.6 13.7 13.4 18.9 20.4 RNV 15.0 16.8 19.6 16.0 16.3 18.9 17.3 21.5 21.3 15.1 18.6 15.9 20.3 14.1 19.6 16.0 18.5 DuPont-5990 Company Sanitized. Does not contain TSCA CBI -728 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Male, Group: I - 0 mg/kg - Day 39 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 TRACE NONE NONE NONE NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: III - 25 mg/kg - Day 39 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 NONE NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 145 81 71 97 70 87 84 101 77 74 117 92 78 63 75 70 75 72 70 70 47 31 35 34 29 37 38 44 36 30 31 37 33 27 33 30 38 36 33 33 Company Sanitized. Does not contain TSCA CBI -729- ) DuPont-5990 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 29..2 14 .6 16..7 25..6 13..6 21,.4 17..7 18..4 25..1 15..0 22 .4 19 .3 19..2 17..3 25..4 17..6 25..1 20..7 16..7 16..8 112 <0..10 217 0..10 129 0..13 161 <0..10 109 0..11 119 <0..10 101 <0..10 161 <0..10 138 0..10 143 0..12 107 <0 .10 112 <0 .10 166 <0 .10 130 0 .11 170 0..13 124 <0..10 87 <0..10 134 <0,.10 130 <0..10 121 <0..10 15 0..32 14 0..40 15 0..33 13 0.,29 15 0..27 13 0..33 14 0..28 12 0..30 15 0..33 11 0..33 16 0..37 15 0..38 14 0..33 10 0,.30 13 0..33 15 0..38 13 0..30 14 0..34 14 0..33 14 0..29 80 56 52 68 67 72 55 54 67 67 42 88 57 63 59 61 77 78 54 76 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Male, Group: V - 100 mg/kg - Day 39 646349 NONE NONE NONE 79 38 646373 NONE NONE NONE 79 57 646385 TRACE NONE NONE 70 35 646435 TRACE NONE NONE 60 32 646455 NONE NONE NONE 86 41 646456 NONE NONE NONE 67 38 646463 TRACE NONE NONE 76 32 646469 NONE NONE NONE 67 37 646472 NONE NONE NONE 57 27 646488 NONE NONE NONE 73 45 Male, Group: VII - 500 mg/kg - Day 39 646343 TRACE NONE NONE 61 44 646346 TRACE NONE NONE 76 76 646347 NONE NONE NONE 59 40 646388 NONE NONE NONE 72 49 646407 NONE NONE NONE 86 57 646413 TRACE NONE NONE 81 54 646433 TRACE NONE NONE 82 65 646437 TRACE NONE NONE 76 64 646442 SMALL NONE NONE 66 59 646475 NONE NONE NONE 78 84 Company Sanitized. Does not contain TSCA CBI -730- DuPont-5990 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 23.1 22.2 20.0 18.3 22.9 21.9 20.2 16.5 17.4 22.7 22.0 34.5 22.4 25.3 57.1 20.1 26.5 19.9 20.9 20.4 129 0.11 138 <0.10 125 <0.10 112 <0.10 93 <0.10 131 0.10 116 0.14 147 0.10 148 0.15 123 <0.10 191 260 143 174 133 155 129 168 254 135 0.17 0.20 0.17 0.22 0.21 0.22 0.20 0.19 0.31 0.12 16 0.38 14 0.35 10 0.31 16 0.42 15 0.27 14 0.41 13 0.35 16 0.28 17 0.43 16 0.37 21 0.43 20 0.37 18 0.39 18 0.48 25 0.44 19 0.31 19 0.39 23 0.44 18 0.46 16 0.33 88 119 98 115 97 111 103 88 103 82 97 170 88 154 109 54 78 67 100 100 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Male, Group: I - 0 mg/kg - Day 39 646360 68 95 6.3 4.1 2.2 11.4 10.3 147.9 646367 37 95 6.8 4.4 2.4 11.1 7.7 147.6 646374 103 118 6.5 4.1 2.4 11.3 8.6 145.4 646379 60 107 6.3 4.4 1.9 10.8 9.0 145.9 646420 91 99 6.2 3.9 2.3 11.0 8.3 146.3 646427 59 91 6.9 4.3 2.6 11.0 8.6 144.3 646482 74 95 6.2 3.9 2.3 11.3 9.3 146.6 646485 53 98 6.3 3.9 2.4 10.0 9.0 146.8 646489 40 108 6.7 4.4 2.3 11.3 9.5 146.1 646492 45 104 6.5 3.9 2.6 11.4 8.3 147.2 Male, Group: III - 25 mg/kg - Day 39 646370 38 98 6.7 4.4 2.3 10.6 9.1 145.2 646399 126 103 6.3 4.2 2.1 11.5 9.1 146.0 646414 57 103 6.0 4.0 2.0 10.2 9.4 147.6 646421 63 97 6.4 4.2 2.2 11.2 8.5 145.2 646423 53 98 6.6 4.3 2.3 11.3 8.9 146.9 646426 70 99 6.8 4.4 2.4 11.5 8.5 146.9 646443 123 97 6.6 4.2 2.4 11.3 8.9 146.7 646454 51 102 6.9 4.3 2.6 11.2 8.8 147.0 646458 43 107 6.7 4.4 2.3 11.1 8.9 146.8 646471 90 114 6.6 4.2 2.4 11.6 8.9 143.2 K mmol/L 6.46 5.64 6.16 6.15 5.61 6.19 6.11 5.98 6.05 5.72 6.17 5.75 5.93 5.94 5.73 5.70 6.86 6.29 6.31 6.02 CL mmol/L 97.0 99.5 99.1 97.8 97.1 98.3 97.6 97.4 98.8 95.3 100.8 97.1 99.3 95.8 99.2 97.5 99.1 99.2 98.4 94.2 Company Sanitized. Does not contain TSCA CBI -731 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L K mmol/L CL mmol/L Male, Group: V - 100 mg/kg - Day 39 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 43 102 6.7 4.4 2.3 11.1 9.5 146.4 6.16 99.9 58 108 7.5 4.6 2.9 12.3 9.6 146.2 6.47 93.7 24 100 7.1 4.5 2.6 11.8 8.8 146.2 5.98 95.8 31 101 7.4 4.7 2.7 11.5 8.6 144.7 6.56 97.0 33 92 6.9 4.6 2.3 11.7 8.8 146.2 6.52 95.7 40 101 6.7 4.6 2.1 12.4 10.9 146.6 7.63 98.0 34 83 7.6 5.1 2.5 11.7 9.3 145.6 6.72 97.1 29 93 6.6 4.5 2.1 12.0 9.4 143.7 6.29 96.5 35 91 6.9 4.3 2.6 11.7 9.3 144.9 6.50 97.2 27 89 6.9 4.4 2.5 11.0 9.5 145.6 7.37 99.2 Male, Group: VII - 500 mg/kg - Day 39 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 29 102 7.4 5.1 2.3 11.6 8.7 143.7 6.19 94.1 37 93 7.5 5.1 2.4 11.6 8.6 141.3 6.55 93.5 29 106 7.0 4.9 2.1 11.5 9.2 143.4 7.06 97.7 30 104 7.8 5.3 2.5 12.6 9.1 145.5 6.27 95.5 31 95 7.5 5.1 2.4 11.9 9.7 144.8 7.15 94.7 26 101 6.5 4.6 1.9 11.1 8.4 143.4 6.89 98.2 23 88 7.2 4.9 2.3 11.6 8.7 143.9 7.11 97.1 16 87 7.4 5.1 2.3 11.7 9.7 143.8 6.83 95.1 21 93 7.6 5.5 2.1 11.9 8.7 143.3 6.78 95.7 33 98 7.1 4.9 2.2 11.7 8.9 145.2 6.64 96.3 Company Sanitized. Does not contain TSCA C8I -732 - ))) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________________DuPont-5990 Animal Number SPEC Male, Group: I - 0 mg/kg - Day 39 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 Male, Group: III - 25 mg/kg - Day 39 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 Individual Serum and Plasma Chemistry Values Company Sanitized. Does not contain TSCA CBI -733 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number SPEC Male, Group: V - 100 mg/kg - Day 39 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 Male, Group: VII - 500 mg/kg - Day 39 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 Individual Serum and Plasma Chemistry Values DuPont-5990 Company Sanitized. Does not contain TSCA CBI -734- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Male, Group: I - 0 mg/kg -- Day 95 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 SMALL NONE TRACE NONE NONE NONE NONE TRACE TRACE SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: III - 25 mg/kg - Day 95 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 NONE NONE NONE NONE NONE SMALL TRACE TRACE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 92 83 80 87 81 99 77 84 77 80 106 101 89 113 69 92 82 72 93 86 31 29 35 40 44 33 29 34 29 26 30 39 28 32 28 29 38 30 70 33 Company Sanitized. Does not contain TSCA CBI -735 - ) DuPont-5990 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 22..3 12..2 17..2 35..4 27,,6 26..5 20,.0 21..8 20..8 19..5 14.2 27.3 21.2 20.3 24.6 24.3 28.0 26.9 41.7 24.7 69 0..14 114 0..15 98 0,,15 96 0..14 80 0..10 86 0,.15 77 0..12 116 <0..10 80 0..12 87 0..12 67 0.11 81 0.12 89 <0.10 75 0.17 111 <0.10 79 0.11 67 <0.10 84 0.18 74 0.13 75 0.10 14 0.,28 14 0..37 17 0.,39 14 0..34 24 0..44 14 0,.42 15 0..29 13 0..43 16 0,.43 14 0..44 19 0.43 18 0.48 17 0.41 14 0.38 17 0.44 19 0.39 20 0.41 15 0.39 15 0.34 15 0.42 98 54 75 84 73 85 62 68 70 75 46 123 64 84 73 79 86 87 106 97 )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Male, Group: V - 100 mg/kg - Day 95 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 NONE NONE TRACE TRACE TRACE TRACE NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: VII - 500 mg/kg - Day 95 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 NONE TRACE TRACE NONE NONE NONE SMALL SMALL SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE TRACE NONE 86 70 81 70 80 92 90 74 81 76 70 93 61 73 74 108 82 74 75 83 38 37 31 37 32 37 40 43 35 43 46 64 39 45 42 51 52 49 45 63 Company Sanitized. Does not contain TSCA CBI -736- ) DuPont-5990 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 42.1 24.8 26.8 23.8 21.3 26.9 24.5 29.3 30.0 27.5 36..3 29..8 25..6 30..7 23..7 22..3 34.,5 26,.3 31.,4 29..9 71 0.20 79 <0.10 79 0.16 68 0.13 84 <0.10 90 0.17 80 0.21 100 0.18 119 0.20 75 0.19 142 0..23 242 0..20 94 0,.20 138 0..29 90 0..23 106 0.,22 119 0..21 110 0.,22 155 0..37 87 0..21 19 0.54 15 0.43 18 0.42 21 0.50 22 0.42 15 0.52 17 0.39 19 0.50 23 0.48 18 0.50 19 0,.41 18 0..40 19 0,.37 21 0..42 25 0..46 19 0..34 20 0..41 22 0..48 21 0..48 18 0..38 139 163 109 125 60 134 95 99 98 97 116 161 92 146 125 84 81 64 109 116 ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Male, Group: I - 0 mg/kg - Day 95 646360 96 83 6.7 4.2 2.5 10.2 7.6 149.4 646367 38 89 7.0 4.3 2.7 10.4 6.2 149.7 646374 162 110 7.8 4.6 3.2 11.1 7.1 149.1 646379 135 109 7.1 4.7 2.4 10.9 7.0 148.5 646420 60 120 7.2 3.6 3.6 10.9 7.8 148.0 646427 95 103 7.7 4.7 3.0 10.7 6.8 150.2 646482 93 82 7.0 4.3 2.7 10.8 7.5 149.8 646485 71 93 7.2 4.4 2.8 10.0 7.6 148.9 646489 48 98 7.2 4.5 2.7 10.9 7.4 149.3 646492 56 94 7.0 4.0 3.0 11.0 7.2 148.4 Male, Group: III - 25 mg/kg - Day 95 646370 29 93 6.9 4.4 2.5 10.3 8.4 146.6 646399 130 91 7.3 4.6 2.7 11.2 7.8 148.2 646414 97 88 7.0 4.5 2.5 10.1 7.9 147.5 646421 74 98 7.5 4.8 2.7 10.9 7.1 149.2 646423 46 96 7.1 4.5 2.6 10.8 7.3 150.4 646426 85 107 7.4 4.6 2.8 11.4 8.8 149.8 646443 154 94 7.3 4.6 2.7 10.9 7.3 148.2 646454 46 96 7.3 4.5 2.8 10.8 7.5 149.2 646458 64 95 7.8 5.2 2.6 11.6 8.2 149.3 646471 170 117 7.6 4.7 2.9 11.3 7.0 148.2 K mmol/L 6.03 5.57 5.85 5.98 5.69 5.89 5.86 6.02 5.72 6.14 6.25 5.86 5.80 5.72 5.55 6.47 6.14 6.49 6.18 6.14 CL mmol/L 98.3 102.8 98.3 97.8 96.9 100.2 99.7 97.7 100.0 98.3 103.2 98.7 102.1 98.0 101.0 100.9 99.0 101.1 98.1 97.3 PHEM NONE NONE NONE NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE TRACE Company Sanitized. Does not contain TSCA CBI - 737 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Pla, TP g/dL ALB g/dL GLOB g/dL Male, Group: V - 100 mg/kg - Day 95 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 69 98 8.2 5.2 3.0 78 101 8.4 5.1 3.3 28 103 7.7 4.8 2.9 35 101 8.1 5.0 3.1 41 133 7.4 4.6 2.8 48 88 8.0 5.3 2.7 29 84 8.2 5.4 2.8 37 110 7.6 5.0 2.6 38 106 8.0 5.0 3.0 43 99 8.3 5.3 3.0 Male, Group: VII - 500 mg/kg - Day 95 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 27 99 8.4 5.7 2.7 32 88 7.9 5.3 2.6 26 96 7.9 5.4 2.5 32 98 8.3 5.5 2.8 22 106 8.0 5.1 2.9 25 96 8.0 5.5 2.5 22 91 8.0 5.3 2.7 16 94 8.2 5.4 2.8 21 94 8.9 6.1 2.8 32 91 8.2 5.5 2.7 Company Sanitized. Does not contain TSCA CBI - 738- DuPont-5990 sma Chemistry Values CALC mg/dL IPHS mg/dL NA mmol/L K mmol/L CL mmol/L PHEM 11.7 11.3 10.5 11.4 11.2 11.3 11.6 11.8 11.2 11.2 11.7 11.1 11.2 12.0 11.3 11.2 11.1 11.3 12.0 11.6 8.0 150.1 7.7 147.3 9.0 147.3 7.3 147.3 9.3 150.5 7.3 148.3 8.1 147.5 9.1 148.1 7.0 148.4 8.1 150.0 7.7 147.4 9.9 143.9 7.2 145.6 8.4 145.8 8.4 145.2 7.0 146.3 7.7 147.2 8.0 145.3 7.9 147.0 7.8 148.4 6.25 6.63 7.58 6.70 6.79 6.84 6.14 7.00 5.89 6.78 98.7 96.4 99.4 99.9 102.8 97.2 95.9 98.6 99.5 98.2 NONE NONE TRACE NONE NONE NONE TRACE NONE NONE NONE 5.89 7.94 6.40 6.35 6.40 6.22 6.90 6.63 6.62 6.35 96.7 100.4 99.4 95.7 97.1 98.8 98.6 96.6 96.1 97.2 NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU Mg/mL Male, Group: I - 0 mg/kg - Day 95 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: III - 25 mg/kg - Day 95 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.2 0.2 0.2 0.3 0.2 0.1 ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -739- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________ Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU Mg/mL Male, Group: V - 100 mg/kg - Day 95 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.2 0.2 0.2 0.2 0.2 0.3 0.2 0.2 0.3 0.2 Male, Group: VII - 500 mg/kg - Day 95 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.5 0.4 0.5 0.5 0.5 0.5 0.5 0.5 0.7 0.4 ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -740- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Male, Group: I - 0 mg/kg - Day 123 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: VII - 500 mg/kg - Day 123 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 178 113 57 120 83 142 108 77 74 78 133 111 132 65 86 92 109 91 161 99 75 45 27 48 35 39 43 32 32 32 60 49 63 36 51 43 56 46 67 63 Company Sanitized. Does not contain TSCA CBI -741 - ) DuPont-5990 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 32.8 25.3 13.2 19.2 15.2 18.6 22.7 18.8 13.0 14.8 41.2 37.3 35.4 29.7 46.8 40.2 49.0 34.6 49.6 60.8 87 0.14 73 0.12 61 0.10 91 0.19 88 0.15 95 0.14 94 0.15 62 0.18 64 0.12 81 0.10 68 0.15 61 0.15 77 0.13 69 0.15 86 0.15 79 0.14 56 0.10 97 0.13 78 0.11 81 0.16 17 0.51 16 0.46 16 0.39 18 0.39 17 0.43 17 0.48 16 0.37 14 0.42 13 0.39 20 0.43 15 0.46 17 0.43 17 0.40 19 0.36 17 0.45 23 0.43 17 0.44 20 0.44 17 0.36 33 0.42 62 71 73 66 78 81 58 75 92 65 133 74 77 89 107 95 72 68 80 73 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Male, Group: I - 0 mg/kg -- Day 123 646371 19 134 7.1 4.3 2.8 11.4 8.1 148.6 646398 46 181 6.9 4.1 2.8 10.8 7.8 146.1 646411 96 105 6.8 4.1 2.7 10.7 8.4 147.2 646416 49 115 6.7 4.1 2.6 10.5 8.6 144.9 646432 91 102 7.0 4.2 2.8 11.2 7.2 147.5 646446 47 114 6.8 4.3 2.5 10.5 8.6 143.9 646459 126 97 7.1 4.3 2.8 10.5 7.7 147.6 646460 97 94 6.3 3.7 2.6 10.9 8.4 148.7 646487 81 118 6.9 4.1 2.8 11.3 6.9 148.3 646494 63 105 6.9 4.0 2.9 10.8 8.1 145.6 Male, Group: VII - 500 mg/kg - Day 123 646337 93 116 7.5 4.6 2.9 11.2 10.2 144.2 646364 72 90 7.4 4.7 2.7 11.4 8.6 149.7 646369 55 123 7.4 4.5 2.9 10.8 9.4 144.5 646372 67 102 7.4 4.7 2.7 11.3 7.5 148.1 646384 153 116 7.5 4.5 3.0 11.4 10.0 146.1 646397 46 104 8.1 5.1 3.0 11.5 8.7 146.2 646428 40 111 7.4 4.5 2.9 11.0 8.7 146.9 646448 69 172 7.7 4.9 2.8 11.8 10.3 146.7 646474 93 101 7.6 4.7 2.9 11.5 9.3 148.1 646484 32 87 7.5 4.6 2.9 11.3 10.1 145.5 K mmol/L 5.90 5.61 6.81 6.96 6.30 6.87 5.99 6.42 5.99 6.82 7.67 6.23 7.30 5.47 7.05 7.18 6.55 5.90 6.51 6.28 CL mmol/L 104.6 103.5 103.9 103.7 101.1 104.2 102.4 101.2 101.0 102.2 101.0 101.3 101.3 102.7 98.8 103.8 103.3 99.9 99.4 100.9 PHEM NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE TRACE NONE TRACE NONE NONE NONE NONE NONE Company Sanitized. Does not contain TSCA O 00 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU g/mL SPEC Male, Group: I - 0 mg/kg - Day 123 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.1 0.1 0.0 0.0 0.2 0.1 0.1 0.0 Male, Group: VII - 500 mg/kg - Day 123 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 DuPont-5990 Company Sanitized. Does not contain TSCA O CD ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Male, Group: I - 0 mg/kg - Day 183 646325 646396 646468 646495 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 93 94 88 127 38 32 40 26 Male, Group: III - 25 mg/kg - Day 183 646368 NONE NONE NONE 98 38 646436 NONE NONE NONE 70 39 646438 NONE NONE NONE 90 42 646449 NONE NONE NONE 105 37 646453 NONE NONE NONE 138 108 Male, Group: V - 100 mg/kg - Day 183 646327 646335 646376 646403 TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 89 89 114 84 35 48 79 38 Male, Group: VII - 500 mg/kg - Day 183 646344 TRACE NONE NONE 184 115 646355 NONE NONE NONE 102 42 646361 NONE NONE NONE 79 53 646391 NONE NONE NONE 136 77 646466 NONE NONE NONE 89 42 Company Sanitized. Does not contain TSCA CBI -744- ) DuPont-5990 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 12.5 9.9 18.0 5.6 16..7 13..9 14..3 20..4 25..1 21.0 16.6 20.8 15.3 34..4 20,.9 18..5 28..0 25..3 84 <0.10 54 0.12 97 0.11 79 0.12 70 0..10 121 0..15 94 <0..10 88 <0..10 118 <0..10 67 <0.10 110 <0.10 89 <0.10 91 <0.10 87 <0..10 105 <0..10 67 <0..10 90 0..10 69 <0..10 18 0.37 14 0.38 16 0.43 18 0.54 12 0..41 16 0,.45 12 0..32 18 0..38 17 0..46 14 0.42 15 0.41 14 0.29 14 0.39 19 0..59 18 0..45 17 0..38 17 0..51 17 0..44 77 64 145 76 50 75 57 75 141 85 91 52 104 108 59 107 58 68 ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plas TP g/dL ALB g/dL GLOB g/dL Male, Group: I - 0 mg/kg - Day 183 646325 108 86 7.7 4.5 3.2 646396 39 92 7.2 4.2 3.0 646468 104 103 7.8 4.7 3.1 646495 45 90 7.0 4.4 2.6 Male, Group: III - 25 mg/kg - Day 183 646368 122 98 7.1 4.4 2.7 646436 76 88 7.8 4.6 3.2 646438 165 91 7.3 4.5 2.8 646449 111 ' 140 7.0 4.0 3.0 646453 103 85 7.0 3.7 3.3 Male, Group: V - 100 mg/kg - Day 183 646327 115 117 7.8 4.6 3.2 646335 153 107 7.5 4.4 3.1 646376 51 88 7.1 4.2 2.9 646403 180 107 7.6 4.2 3.4 Male, Group: VII - 500 mg/kg - Day 183 646344 81 134 7.6 4.4 3.2 646355 74 91 7.2 4.4 2.8 646361 114 105 7.2 4.0 3.2 646391 52 142 7.8 4.8 3.0 646466 91 107 7.7 4.3 3.4 Company Sanitized. Does not contain TSCA CBI -745- DuPont-5990 ma Chemistry Values CALC mg/dL IPHS mg/dL NA mmol/L K mmol/L CL mmol/L PHEM 10.4 9.9 10.7 9.5 9.9 10.4 10.4 10.4 10.3 10.9 10.4 9.9 10.2 11.1 10.4 10.4 10.8 10.5 6.7 146.5 7.5 145.0 6.6 148.3 6.7 146.9 6.1 147.9 6.5 147.3 7.1 149.6 7.8 147.6 7.0 148.4 8.4 151.1 6.8 145.3 8.1 147.7 6.6 148.1 10.3 7.0 8.6 11.7 7.1 149.9 149.9 147.3 153.1 150.4 6.46 6.51 5.94 5.77 97.3 100.6 99.6 100.8 NONE SMALL NONE NONE 5.80 6.38 5.83 5.97 6.15 100.8 99.6 100.3 103.3 100.1 NONE NONE NONE NONE NONE 7.19 6.41 6.32 6.17 103.1 99.4 104.3 100.3 NONE NONE NONE NONE 7.07 6.23 6.44 6.70 5.92 104.9 100.2 103.6 109.1 100.0 NONE NONE TRACE NONE NONE ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU g/mL SPEC Male, Group: I - 0 mg/kg - Day 183 646325 646396 646468 646495 NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.1 0.1 Male, Group: III - 25 mg/kg - Day 183 646368 646436 646438 646449 646453 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.1 0.1 0.1 Male, Group: V - 100 mg/kg - Day 183 646327 646335 646376 646403 NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.1 0.1 Male, Group: VII - 500 mg/kg - Day 183 646344 646355 646361 646391 646466 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.1 0.1 0.1 Sample status: NECROPSY SAMPLE-FROZEN AT -70C ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -746- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________ ) DuPont-5990 Animal Number SHEM SLIP Individual Serum and Plasma Chemistry Values SICT AST IU/L ALT IU/L SDH IU/L ALKP IU/L Female, Group: II - 0 mg/kg - Day 40 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 NONE NONE NONE TRACE NONE NONE SMALL NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: IV - 25 mg/kg - Day 40 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 TRACE TRACE NONE TRACE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 79 74 89 78 85 80 77 77 125 80 90 97 119 86 75 94 63 103 85 114 32 17.6 29 20.0 35 24.7 42 21.2 28 22.5 39 15.5 32 19.4 39 19.4 51 20.3 33 23.8 33 18.8 37 22.1 69 34.8 35 18.7 35 20.2 49 20.9 35 14.3 45 21.2 35 17.0 41 19.9 75 112 89 118 68 93 73 77 66 74 99 114 69 80 74 79 79 99 92 133 BILI mg/dL 0.15 <0.10 0.20 0.17 0.14 0.14 0.16 0.13 0.16 0.11 0.16 0.16 0.14 0.12 0.12 0.10 0.18 0.12 0.15 0.14 BUN mg/dL 13 17 14 15 14 16 19 17 16 16 18 18 16 12 14 16 10 17 17 17 CREA mg/dL 0.45 0.45 0.37 0.38 0.32 0.38 0.37 0.38 0.32 0.43 0.42 0.37 0.44 0.36 0.38 0.31 0.34 0.36 0.34 0.37 CHOL mg/dL 88 52 84 72 65 78 87 102 91 120 92 76 93 87 90 102 100 111 95 73 Company Sanitized. Does not contain TSCA CBI -747- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Female, Group: VI - 100 mg/kg - Day 40 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: VIII - 500 mg/kg - Day 40 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 NONE NONE NONE NONE TRACE NONE TRACE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE TRACE 62 68 72 81 62 59 71 63 74 113 80 73 62 67 86 86 100 71 63 60 36 47 54 49 69 35 30 41 44 48 65 59 56 66 45 84 58 69 45 41 Company Sanitized. Does not contain TSCA CBI -748 - ) DuPont-5990 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 15.9 19.5 20.1 19.6 18.9 19.8 17.2 14.6 20.0 17.1 19..6 15..4 19..9 14..9 20..0 23..6 20..0 19..8 18..1 17..0 97 0.14 64 0.15 69 0.16 107 0.11 69 0.19 125 0.13 68 0.14 70 0.16 104 0.15 90 <0.10 190 0 .19 115 0 .12 164 0 .18 159 0..18 111 0..18 299 0 .23 113 0 .14 146 0..19 88 0..18 98 0..21 15 0.37 15 0.38 16 0.35 25 0.42 16 0.38 15 0.35 17 0.39 15 0.36 17 0.36 18 0.36 24 0..39 20 0,.41 23 0..47 17 0..42 18 0..41 29 0,.48 23 0..45 23 0..47 17 0..40 20 0..47 99 148 154 117 157 109 113 120 105 108 120 137 125 99 143 99 117 104 148 106 ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Female, Group: II - 0 mg/kg - Day 40 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 55 99 8.1 5.8 2.3 11.4 6.4 147.2 28 107 6.8 4.6 2.2 11.5 8.5 146.6 32 98 7.1 4.8 2.3 11.0 7.4 145.4 81 100 8.0 5.3 2.7 11.7 7.9 144.6 34 99 7.1 5.0 2.1 10.7 6.7 146.1 54 94 7.5 5.1 2.4 11.5 7.5 145.8 42 103 6.9 4.8 2.1 10.6 7.3 144.5 30 119 6.9 4.7 2.2 10.9 7.4 147.3 24 91 7.2 5.1 2.1 10.9 6.7 144.9 70 103 7.9 5.1 2.8 11.5 7.0 146.4 Female, Group : IV - 25 mg/kg - Day 40 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 33 91 7.5 5.4 2.1 11.5 7.4 145.8 50 97 6.7 4.7 2.0 11.3 8.6 145.0 40 105 7.8 5.5 2.3 11.4 6.9 146.4 42 105 7.6 4.9 2.7 11.0 6.9 142.2 43 93 7.2 5.1 2.1 11.1 7.5 146.1 36 113 7.1 4.9 2.2 10.8 7.1 144.8 75 111 8.2 5.7 2.5 11.9 7.5 144.5 39 91 7.2 4.8 2.4 11.4 8.1 145.4 32 100 7.3 5.0 2.3 11.1 7.9 147.4 28 98 6.8 4.6 2.2 10.6 7.2 146.3 K mmol/L 5.31 5.39 6.07 5.80 5.39 5.47 5.97 5.36 5.24 6.30 6.14 6.09 5.86 5.41 5.85 5.68 5.56 6.38 5.87 5.61 CL mmol/L 98.9 100.1 98.2 97.9 100.0 100.2 98.7 97.0 99.3 98.5 100.2 99.3 98.8 98.1 99.3 100.6 96.6 100.0 99.4 99.6 Company Sanitized. Does not contain TSCA CBI -749- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Female, Group: VI - 100 mg/kg - Day 40 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 37 109 8.2 6.0 2.2 11.9 7.0 145.7 50 99 8.6 6.4 2.2 12.0 6.7 145.2 34 93 7.2 5.0 2.2 11.5 8.7 144.4 43 89 8.1 5.7 2.4 12.1 9.2 143.2 65 96 8.9 6.4 2.5 13.2 7.9 144.6 29 109 7.4 5.3 2.1 11.6 7.7 146.9 32 98 7.8 5.5 2.3 11.3 7.1 144.9 29 106 7.6 5.7 1.9 11.3 6.7 144.9 31 103 7.3 5.2 2.1 11.3 7.1 144.3 20 104 7.5 5.4 2.1 11.3 9.0 141.8 Female, Group: VIII -- 500 mg/kg - Day 40 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 30 104 7.8 5.7 2.1 11.6 8.6 141.1 31 110 7.3 5.3 2.0 11.5 8.5 141.6 26 102 8.0 5.6 2.4 11.3 9.6 144.5 26 105 7.6 5.3 2.3 11.6 7.5 143.9 26 97 7.4 5.3 2.1 12.2 9.6 145.2 21 120 7.6 5.5 2.1 12.7 10.9 145.1 24 88 7.1 5.1 2.0 11.3 9.8 142.5 24 110 7.8 5.6 2.2 11.8 8.2 143.4 27 106 8.3 6.0 2.3 12.2 7.4 144.7 19 94 7.7 5.6 2.1 11.6 8.7 143.4 K mmol/L 5.69 5.73 5.94 6.35 5.51 6.28 5.76 5.85 6.01 6.78 6.27 6.39 6.69 5.96 7.55 5.88 6.55 6.08 5.92 6.14 CL mmol/L 98.5 97.0 98.3 94.6 93.4 97.3 99.0 100.6 97.2 100.0 95.9 95.1 96.0 95.5 99.0 95.3 98.0 95.2 95.9 97.3 Company Sanitized. Does not contain TSCA CBI - 750- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________ Animal Number SPEC Female, Group: II - 0 mg/kg - Day 40 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 Female, Group: IV - 25 mg/kg - Day 40 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 Individual Serum and Plasma Chemistry Values ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -751 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number SPEC Individual Serum and plasma Chemistry Values Female, Group: VI - 100 mg/kg - Day 40 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 Female, Group: VIII - 500 mg/kg - Day 40 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 ) DuPont-5990 Company Sanitized. Does not contain TSCA C8I -752- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Female, Group: II - 0 mg/kg - Day 96 646537 NONE NONE NONE 187 73 646538 NONE NONE NONE 78 36 646560 TRACE NONE NONE 86 31 646592 NONE TRACE NONE 76 40 646612 NONE NONE NONE 69 30 646617 NONE NONE NONE 81 38 646649 TRACE NONE NONE 93 32 646659 TRACE NONE NONE 75 36 646665 TRACE NONE NONE 324 227 646676 TRACE NONE NONE 206 120 Female, Group : IV - 25 mg/kg - Day 96 646502 TRACE NONE NONE 90 35 646522 TRACE NONE NONE 68 30 646567 NONE NONE NONE 104 43 646576 TRACE NONE NONE 281 146 646595 NONE NONE NONE 71 38 646621 NONE NONE NONE 71 47 646635 NONE NONE NONE 83 37 646660 TRACE NONE NONE 91 41 646664 NONE NONE NONE 65 32 646673 NONE NONE NONE 138 48 Company Sanitized. Does not contain TSCA CBI - 753 - DuPont-5990 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 55.7 13.9 16.9 18.0 13.2 13.1 15.1 14.8 41.5 45.1 13.9 16.7 37.6 47.8 18.1 19.8 15.0 19.2 14.0 17.1 34 0.22 52 0.12 70 0.20 56 0.17 40 0.16 51 0.13 39 0.18 38 0.13 37 0.19 36 0.16 48 0.16 69 0.18 39 0.14 48 0.12 36 0.16 40 0.19 43 0.14 49 0.18 38 0.11 48 0.16 17 0.40 16 0.45 14 0.38 13 0.42 14 0.44 17 0.39 16 0.54 18 0.52 18 0.37 18 0.48 19 0.45 19 0.45 17 0.41 20 0.48 16 0.42 18 0.36 16 0.40 24 0.49 17 0.45 19 0.35 105 67 73 84 83 95 127 97 111 141 91 86 110 124 111 115 115 145 113 80 ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 Animal Number SHEM SLIP Individual Serum and Plasma Chemistry Values SICT AST IU/L ALT IU/L SDH IU/L ALKP IU/L Female, Group: VI - 100 mg/kg - Day 96 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 NONE NONE NONE NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: VIII -- 500 mg/kg - Day 96 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 NONE NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 55 72 115 103 69 69 58 58 66 88 66 72 63 64 156 83 91 69 73 57 39 13.9 51 22.3 46 21.3 40 12.1 49 17.4 34 13.2 34 13.6 36 16.5 30 17.0 42 19.3 53 14.4 64 15.2 40 19.3 44 16.6 52 19.8 45 14.9 50 19.7 54 21.8 43 29.8 33 14.1 85 28 29 61 43 59 41 43 66 54 119 108 118 64 78 187 90 77 39 53 BILI mg/dL 0.22 0.16 0.17 0.10 0.16 0.12 0.17 0.19 0.17 0.11 0.26 0.17 0.20 0.20 0.23 0.11 0.16 0.23 0.26 0.25 BUN mg/dL 20 20 21 21 17 17 18 15 21 17 20 20 16 22 19 18 23 23 19 20 CREA mg/dL 0.45 0.36 0.51 0.44 0.46 0.39 0.51 0.47 0.49 0.47 0.50 0.49 0.47 0.49 0.48 0.41 0.54 0.56 0.49 0.56 CHOL mg/dL 161 219 205 145 194 112 143 126 115 124 130 119 247 155 154 87 145 132 187 123 Company Sanitized. Does not contain TSCA CBI -754- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plas TP g/dL ALB g/dL GLOB g/dL Female, Group: II - 0 mg/kg - Day 96 646537 104 110 8.6 6.1 2.5 646538 49 107 7.3 5.0 2.3 646560 40 99 7.2 4.8 2.4 646592 214 97 8.5 5.8 2.7 646612 49 105 8.1 5.7 2.4 646617 69 98 8.2 5.3 2.9 646649 54 105 7.7 5.2 2.5 646659 48 113 7.7 5.3 2.4 646665 32 102 7.4 5.1 2.3 646676 76 98 8.5 5.6 2.9 Female, Group: IV - 25 mg/kg - Day 96 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 30 92 7.8 5.6 2.2 41 104 7.3 5.0 2.3 59 104 8.6 6.1 2.5 64 107 9.0 5.9 3.1 50 106 8.1 5.7 2.4 56 112 8.3 5.6 2.7 58 106 9.0 6.2 2.8 42 96 9.2 6.2 3.0 34 99 8.6 5.9 2.7 25 94 7.2 5.0 2.2 Company Sanitized. Does not contain TSCA CBI -755 - ) DuPont-5990 ma Chemistry Values CALC mg/dL IPHS mg/dL NA mmol/L K mmol/L CL mmol/L PHEM 12.0 11.3 10.8 11.9 11.3 11.6 10.9 11.1 10.6 11.2 11.1 11.3 11.7 11.7 11.4 11.9 11.7 12.0 11.5 10.6 5.6 145.2 6.5 145.7 5.2 147.0 5.1 145.3 5.4 146.4 6.0 147.1 5.3 146.4 5.3 146.1 5.0 144.8 5.3 144.0 5.5 145.2 6.3 146.2 5.8 145.5 6.8 143.8 5.6 144.6 6.4 146.6 5.6 145.1 6.2 145.5 5.1 146.6 5.4 147.1 5.36 4.78 5.88 5.16 5.17 5.94 5.72 5.65 5.52 5.82 99.0 101.3 101.0 99.6 101.1 101.1 104.1 99.7 103.9 99.5 NONE TRACE TRACE TRACE TRACE NONE NONE TRACE NONE NONE 5.98 5.67 5.22 5.96 5.61 5.68 5.11 4.82 5.58 5.08 100.6 101.0 97.7 99.7 99.2 100.6 99.3 96.1 99.4 101.7 NONE TRACE NONE NONE TRACE NONE TRACE TRACE NONE NONE H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Female, Group: VI - 100 mg/kg - Day 96 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 59 118 9.4 72 98 9.2 34 86 8.9 44 88 8.3 33 81 8.9 36 106 8.2 34 95 8.9 23 103 8.9 26 99 8.5 31 114 8.8 Female, Group : VIII -- 500 mg/kg - Day 96 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 23 100 9.1 24 102 9.0 27 101 8.5 24 103 9.0 25 98 8.4 25 98 8.2 22 90 8.1 18 108 8.7 25 109 9.6 15 93 9.1 6.6 6.5 6.2 5.7 . 6.2 5.8 6.2 6.3 6.0 6.0 2.8 2.7 2.7 2.6 2.7 2.4 2.7 2.6 2.5 2.8 6.5 2.6 6.1 2.9 5.6 2.9 6.4 2.6 5.8 2.6 5.9 2.3 5.5 2.6 6.2 2.5 6.8 2.8 6.5 2.6 12.5 12.4 12.3 11.7 12.2 11.6 11.9 11.8 11.9 12.4 12.3 12.3 11.9 12.2 12.3 12.0 11.5 12.3 12.7 12.0 6.7 145.1 5.3 145.8 6.8 146.1 7.9 142.5 6.6 145.7 5.0 145.2 5.4 144.2 5.7 145.7 6.2 145.8 7.6 147.3 6.6 146.5 7.2 146.0 6.5 145.3 6.5 143.5 7.7 148.4 7.2 143.9 7.5 143.1 6.8 145.3 6.4 144.0 6.2 146.0 K mmol/L 5.15 4.70 5.81 6.17 5.16 5.49 5.29 5.17 5.70 6.61 5.67 6.02 5.65 5.82 7.14 6.30 5.84 6.08 5.36 5.63 CL mmol/L 98.6 96.8 99.8 102.3 96.4 98.6 96.9 98.0 97.7 99.5 99.5 97.3 96.5 95.7 102.8 97.7 95.5 97.3 93.8 98.4 PHEM NONE NONE NONE NONE NONE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE TRACE TRACE NONE NONE NONE Company Sanitized. Does not contain TSCA CBI -756- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU tg/mL Female, Group: II - 0 mg/kg - Day 96 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.2 0.2 0.1 Female, Group: IV - 25 mg/kg - Day 96 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 DuPont-5990 Company Sanitized. Does not contain TSCA O ro )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-5990 Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU ag/mL Female, Group: VI - 100 mg/kg - Day 96 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 NONE NONE .NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.2 0.1 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Female, Group: VIII -- 500 mg/kg - Day 96 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.6 0.3 0.6 0.5 0.5 0.6 0.4 0.4 0.7 0.4 Company Sanitized. Does not contain TSCA CBI - 758 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Female, Group: II - 0 mg/kg - Day 124 646511 NONE NONE NONE 134 75 646549 TRACE NONE NONE 83 37 646551 NONE NONE NONE 70 32 646565 NONE NONE NONE 175 113 646580 NONE NONE NONE 87 33 646581 NONE NONE NONE 109 43 646586 NONE NONE NONE 247 140 646613 TRACE NONE NONE 100 40 646627 NONE NONE NONE 67 44 646652 TRACE NONE NONE 100 62, Female, Group: VIII - 500 mg/kg - Day 124 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 120 94 90 89 117 96 74 69 77 70 41 43 36 42 45 33 29 28 24 23 Company Sanitized. Does not contain TSCA C8I -759- ) DuPont-5990 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 31.9 20.3 21.7 34.2 18.4 25.1 33.6 26.5 19.1 19.7 18,.2 47 .4 26,,8 30..9 57,.0 21,.3 21,.3 18..6 19..8 19.,4 43 0.20 33 0.21 38 0.17 36 0.16 57 0.14 29 0.16 30 0.23 47 0.14 48 0.21 28 0.23 60 0..15 28 0..12 28 0,.21 22 0..19 31 0,.20 54 0..13 42 0,.16 26 0..14 36 0..18 37 0..12 14 0.46 20 0.50 17 0.54 15 0.52 16 0.49 15 0.48 22 0.53 19 0.63 14 0.49 16 0.45 21 0..42 18 0..50 18 0..53 16 0..40 17 0..55 14 0..48 22 0..50 20 0..53 20 0..58 14 0..47 71 135 90 104 56 90 111 59 129 120 89 130 115 195 158 128 165 121 145 132 ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number TRIG mg/dL G LUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA rnmol/L Female, Group: II - 0 mg/kg - Day 124 646511 151 95 7.7 5.2 2.5 11.1 5.7 143.5 646549 104 103 8.2 5.9 2.3 11.4 8.0 140.6 646551 99 103 8.5 6.0 2.5 11.5 6.1 142.8 646565 84 108 8.0 5.5 2.5 11.1 6.2 144.6 646580 40 98 7.6 4.7 2.9 10.8 6.3 143.7 646581 118 100 8.4 5.6 2.8 11.5 6.2 146.8 646586 62 113 8.3 5.7 2.6 11.8 6.6 141.7 646613 139 124 8.6 5.9 2.7 12.1 7.8 147.6 646627 52 99 8.8 6.0 2.8 11.8 5.7 145.0 646652 108 113 8.1 5.6 2.5 11.6 5.8 141.2 Female, Group: VIII - 500 mg/kg - Day 124 646506 46 90 8.3 5.3 3.0 10.7 8.2 143.5 646508 115 92 9.2 6.0 3.2 12.2 6.7 144.1 646540 50 87 8.7 6.1 2.6 11.5 6.4 144.9 646542 89 103 8.6 5.6 3.0 11.1 6.5 145.0 646545 120 92 9.4 6.2 3.2 12.4 6.9 143.9 646548 71 93 9.5 6.3 3.2 11.8 6.4 144.5 646599 53 100 8.9 6.2 2.7 11.7 6.7 143.8 646618 64 81 8.3 5.4 2.9 11.3 6.3 146.7 646637 93 91 9.3 6.2 3.1 11.6 6.2 143.8 646650 75 92 8.5 5.2 3.3 11.5 7.8 142.4 K mmol/L 5.24 6.23 6.14 6.50 5.55 6.00 5.38 7.48 5.31 5.20 6.85 5.20 5.13 5.92 5.26 5.18 6.44 5.85 5.39 7.22 CL mmol/L 97.8 96.6 98.5 102.0 99.0 97.6 97.6 102.5 95.8 96.6 100.7 97.1 98.1 97.9 96.5 96.5 101.1 99.7 95.0 98.9 PHEM SMALL TRACE SMALL NONE NONE NONE NONE NONE TRACE NONE NONE TRACE NONE NONE NONE NONE NONE SMALL TRACE NONE Company Sanitized. Does not contain TSCA CBI -760- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU g/mL Female, Group: II - 0 mg/kg - Day 124 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 Female, Group: VIII - 500 mg/kg - Day 124 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.0 0.1 0.1 0.0 0.0 0.1 0.2 0.1 0.0 I DuPont-5990 Company Sanitized. Does not contain TSCA CBI -761 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Female, Group: II - 0 mg/kg - Day 183 646507 646530 646588 646597 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: IV - 25 mg/kg - Day 183 646531 646568 646625 646626 646636 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: VI - 100 mg/kg - Day 183 646533 646630 646632 646634 646656 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: VIII - 500 mg/kg - Day 183 646523 646528 646601 646620 646667 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 171 107 81 79 91 109 67 54 72 115 74 65 113 95 155 92 90 159 95 85 38 28 37 50 35 30 44 35 35 27 45 70 41 63 40 23 90 38 Company Sanitized. Does not contain TSCA CBI -762- ) DuPont-5990 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 16.1 9.7 10.5 19.4 13.4 7.7 14.5 11.9 11.9 15.1 20.3 10.7 18.9 18.7 23.1 11.5 10.4 18.3 27.9 44 0.15 24 0.14 35 0.18 28 0.11 35 0.11 27 <0.10 23 0.20 37 0.16 59 0.10 32 <0.10 19 0.10 22 0.10 31 <0.10 30 0.12 50 0.16 58 0.11 29 0.12 54 0.10 29 0.12 14 0.56 20 0.56 16 0.52 11 0.40 20 0.51 16 0.45 14 0.47 14 0.40 17 0.52 18 0.59 13 0.60 18 0.46 23 0.57 16 0.44 15 0.54 19 0.45 17 0.52 20 0.51 20 0.47 94 130 81 106 133 170 137 111 92 84 228 126 91 183 121 87 174 111 174 ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Pla TP g/dL ALB g/dL GLOB g/dL Female, Group: II - 0 mg/kg - Day 183 646507 33 104 8.0 5.2 2.8 646530 101 93 8.4 5.3 3.1 646588 37 87 8.6 5.9 2.7 646597 105 107 8.4 5.5 2.9 Female, Group: IV - 25> mg/kg - Day 183 646531 190 92 8.2 5.4 2.8 646568 125 100 8.3 5.5 2.8 646625 87 92 8.7 5.9 2.8 646626 119 117 9.0 6.1 2.9 646636 139 96 8.2 5.5 2.7 Female, Group: VI - 100 mg/kg - Day 183 646533 79 101 8.8 5.3 3.5 646630 119 100 9.5 5.7 3.8 646632 67 104 8.5 5.5 3.0 646634 57 99 8.0 4.9 3.1 646656 420 104 8.5 5.4 3.1 Female, Group: VIII - 500 mg/kg - Day 183 646523 45 117 8.4 5.1 3.3 646528 103 93 8.1 4.8 3.3 646601 114 116 9.1 5.9 3.2 646620 75 100 8.0 4.7 3.3 646667 202 103 9.0 5.5 3.5 Company Sanitized. Does not contain TSCA CBI -763 ) DuPont-5990 sma Chemistry Values CALC mg/dL IPHS mg/dL NA mmol/L K mmol/L CL mmol/L PHEM 10.6 10.5 10.7 10.9 10.9 11.1 11.2 11.2 11.2 11.6 12.4 11.2 10.7 10.6 11.5 10.6 12.2 10.4 11.3 5.8 144.5 4.5 145.1 4.7 147.4 6.1 142.6 5.2 146.4 5.9 144.8 4.9 147.0 6.1 145.4 5.6 148.5 10.7 8.8 5.1 5.9 5.7 149.8 152.8 146.5 143.8 145.1 7.4 6.9 12.4 5.3 3.8 147.6 143.6 148.9 142.5 145.3 5.62 5.56 4.97 5.29 102.8 103.5 101.0 98.1 NONE TRACE NONE TRACE 5.13 5.95 5.72 5.26 5.77 101.1 101.4 100.6 99.4 100.0 TRACE TRACE NONE TRACE TRACE 6.56 7.07 5.25 5.32 5.14 107.8 103.3 98.8 100.6 100.1 NSR TRACE NONE NONE TRACE 6.74 6.23 7.64 5.54 4.47 105.9 101.7 104.8 100.7 97.3 NONE TRACE NSR NONE NONE H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU (xg/mL Female, Group: II - 0 mg/kg - Day 183 646507 646530 646588 646597 NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.0 0.1 Female, Group: IV - 25 mg/kg - Day 183 646531 646568 646625 646626 646636 NONE NONE NONE NONE NONE NONE NONE NONE No n e NONE 0.1 0.0 0.1 0.1 0.1 Female, Group: VI - 100 mg/kg - Day 183 646533 646630 646632 646634 646656 NT NONE NONE NONE NONE NT NONE NONE NONE NONE NSR 0.0 0.1 0.1 0.1 Female, Group: VIII - 500 mg/kg - Day 183 646523 646528 646601 646620 646667 NONE NONE NT NONE NONE NONE NONE NT NONE NONE 0.1 0.1 NSR 0.1 0.1 DuPont-5990 Company Sanitized. Does not contain TSCA CBI -764- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________________ ) DuPont-5990 Animal Number QUAL COL CLAR Male, Group: 1 - 0 mg/kg - Day 39 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLEAR HAZY HAZY HAZY HAZY CLOUDY CLEAR Male, Group: III - 25 mg/kg - Day 39 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY CLEAR HAZY CLEAR CLEAR CLOUDY HAZY CLEAR HAZY CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG PH UGLU mg/dL KET mg/dL UBIL BLD 26.5 7.0 12.4 8.6 18.0 14.2 9.2 6.3 15.2 23.2 2.6 19.4 28.0 16.8 12.6 6.3 3.3 21.8 7.0 30.2 395 1166 802 1020 540 584 930 1092 614 425 1.014 1.036 1.025 1.030 1.018 1.019 1.029 1.035 1.021 1.014 794 661 373 495 674 1246 2145 476 1110 454 1.024 1.021 1.013 1.016 1.022 1.038 1.061 1.015 1.035 1.015 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 SMALL NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE Company Sanitized. Does not contain TSCA CBI -765 - ))) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-5990 Animal Number QUAL COL CLAR Male, Group: V - 100 mg/kg - Day 39 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 LIGHT MEDIUM LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR HAZY HAZY HAZY CLEAR HAZY CLEAR CLEAR CLEAR HAZY Male, Group: VII - 500 mg/kg - Day 39 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 MEDIUM LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR HAZY CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 5.3 6.0 15.8 2.7 21.0 9.4 10.6 12.2 39.5 7.0 2.5 28.0 48.0 46.0 7.2 31.5 50.3 13.2 30.0 39.0 1368 1901 581 2031 479 772 702 775 214 1198 1.041 1.058 1.019 1.060 1.016 1.025 1.022 1.024 1.007 1.038 2069 436 210 264 1566 306 216 845 349 290 1.059 1.014 1.007 1.009 1.048 1.010 1.007 1.027 1.012 1.010 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE 15 SMALL LARGE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 5 SMALL NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE SMALL NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE Company Sanitized. Does not contain TSCA CBI -766- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number URO EU/dL UMTP mg/dL Male, Group: I - 0 mg/kg - Day 39 646360 0.2 16 646367 0.2 48 646374 0.2 38 646379 0.2 85 646420 0.2 138 646427 0.2 25 646482 0.2 77 646485 0.2 109 646489 0.2 52 646492 0.2 15 Male, Group: III - 25 mg/kg - Day 646370 0.2 74 646399 0.2 31 646414 0.2 13 646421 0.2 24 646423 0.2 35 646426 0.2 122 646443 0.2 178 646454 0.2 19 646458 0.2 81 646471 0.2 14 Individual Urinalysis Values ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -767- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number URO EU/dL UMTP mg/dL SPEC Individual Urinalysis Values Male, Group: V - 100 mg/kg - Day 39 646349 0.2 95 646373 0.2 182 646385 0.2 22 FECAL CONTAMINATION OBSERVED 646435 0.2 197 646455 0.2 34 646456 0.2 36 646463 0.2 36 646469 0.2 43 646472 0.2 9 646488 0.2 129 FECAL CONTAMINATION OBSERVED Male, Group: VII - 500 mg/kg - Day 39 646343 0.2 125 646346 0.2 16 646347 0.2 7 FECAL CONTAMINATION OBSERVED 646388 0.2 12 646407 0.2 159 FECAL CONTAMINATION OBSERVED 646413 0.2 9 646433 0.2 <6 646437 0.2 23 646442 0.2 9 646475 0.2 9 DuPont-5990 Company Sanitized. Does not contain TSCA CBI -768 - )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 Animal Number QUAL COL CLAR Male, Group: I - 0 mg/kg - Day 95 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 MEDIUM MEDIUM MEDIUM MEDIUM LIGHT LIGHT MEDIUM LIGHT MEDIUM LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR HAZY CLEAR CLOUDY HAZY CLEAR HAZY HAZY HAZY Male, Group: III - 25 mg/kg - Day 95 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY CLEAR CLEAR CLEAR CLOUDY HAZY HAZY HAZY CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/ kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 11.0 2.0 6.8 12.2 23.2 11.4 4.0 6.0 11.6 13.2 8.3 13.8 7.9 17.0 7.1 8.0 8.3 19.0 6.2 39.0 1033 1917 1849 995 574 825 2319 1119 832 836 1.036 1.057 1.056 1.031 1.020 1.026 1.068 1.036 1.028 1.027 1076 784 1205 639 1258 1679 1184 672 1493 467 1.034 1.026 1.040 1.023 1.041 1.049 1.039 1.022 1.046 1.016 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 8.5 NEGATIVE NEGATIVE NEGATIVE LARGE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE TRACE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE Company Sanitized. Does not contain TSCA CBI -769- )> H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________ ) DuPont-5990 Animal Number QUAL COL CLAR Male, Group: V - 100 mg/kg - Day 95 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 LIGHT MEDIUM MEDIUM MEDIUM LIGHT LIGHT LIGHT LIGHT MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR HAZY CLEAR CLEAR CLEAR HAZY CLEAR CLEAR HAZY CLEAR Male, Group: VII - 500 mg/kg - Day 95 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR HAZY CLEAR HAZY HAZY CLEAR CLOUDY CLEAR HAZY CLOUDY Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 4.5 7.0 10.8 5.5 19.0 10.2 6.3 7.4 11.4 4.0 27.0 46.0 64.0 40.0 31.0 42.0 19.4 20.6 18.4 64.0 1218 1686 1199 1852 620 867 1084 1008 925 1763 1.039 1.053 1.039 1.055 1.022 1.029 1.036 1.031 1.030 1.054 705 1.023 408 1.016 242 1.009 377 1.014 591 1.022 381 1.015 687 1.024 753 1.025 662 1.024 251 1.009 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 5.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 SMALL NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE TRACE Company Sanitized. Does not contain TSCA CBI -770- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number URO EU/dL UFLU Mg UMTP mg/dL Male, Group : I - 0 mg/kg - Day 95 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 0.2 12.7 0.2 3.8 0.2 12.6 0.2 13.0 0.2 23.9 0.2 10.5 0.2 6.7 0.2 9.4 0.2 14.6 0.2 13.8 Male, Group: III - 25 mg/kg - Day 95 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 0.2 53.5 0.2 48.2 0.2 53.4 0.2 43.3 0.2 45.0 0.2 35.4 0.2 49.2 0.2 54.4 0.2 44.7 0.2 78.9 75 85 169 41 208 40 190 98 62 45 107 40 65 32 78 158 83 23 97 11 Individual Urinalysis Values SPEC > DuPont-5990 Company Sanitized. Does not contain TSCA CBI -771 - )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number URO EU/dL UFLU Mg UMTP mg/dL Male, Group: V - 100 mg/kg - Day 95 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 0.2 86.3 0.2 198.6 0.2 171.0 0.2 115.6 0.2 181.1 0.2 168.1 0.2 117.0 0.2 108.2 0.2 160.7 0.2 101.1 76 172 63 119 37 36 79 70 75 187 Male, Group: VII - 500 mg/kg - Day 95 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 0.2 791.0 0.2 716.8 0.2 660.8 0.2 680.6 0.2 686.6 0.2 575.9 0.2 548.3 0.2 591.6 0.2 499.6 0.2 574.6 23 21 <6 91 169 12 22 17 14 <6 Individual Urinalysis Values ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -772- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number QUAL COL CLAR Male, Group: I - 0 mg/kg - Day 123 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 MEDIUM LIGHT MEDIUM LIGHT LIGHT MEDIUM LIGHT LIGHT MEDIUM LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR HAZY HAZY HAZY HAZY HAZY CLEAR HAZY HAZY Male, Group: VII - 500 mg/kg - Day 123 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY HAZY CLEAR CLEAR CLEAR CLEAR HAZY HAZY CLEAR HAZY Individual Urinalysis Values VOL UOSM mL mOsm/kg SG UGLU mg/dL KET mg/dL UBIL BLD 2.4 20.6 6.8 4.0 8.0 4.8 11.4 14.6 2.5 4.6 9.8 8.0 7.6 5.8 20.4 5.6 10.4 15.2 3.4 11.4 2613 551 1493 1650 1185 1620 839 625 2559 1519 1.075 1.017 1.050 1.054 1.040 1.051 1.025 1.021 1.073 1.048 1366 1027 1127 1603 674 1495 815 1095 2338 1079 1.043 1.034 1.038 1.050 1.022 1.050 1.026 1.034 1.070 1.031 6.5 NEGATIVE 15 SMALL NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE 15 NEGATIVE TRACE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE Company Sanitized. Does not contain TSCA CBI -773 - Company Sanitized. Does not contain TSCA H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number URO EU/dL UFLU Mg UMTP mg/dL Male, Group: I - 0 mg/kg - Day 123 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 0.2 QNS 0.2 11.5 0.2 11.3 0.2 5.1 0.2 7.5 0.2 6.3 0.2 6.9 0.2 10.7 0.2 8.4 0.2 5.2 190 23 149 133 248 124 47 35 184 139 Male, Group: VII - 500 mg/kg - Day 123 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 0.2 90.5 0.2 95.5 0.2 86.3 0.2 93.0 0.2 104.0 0.2 124.8 0.2 152.7 0.2 123.2 0.2 61.6 0.2 51.2 132 64 191 74 84 321 98 104 162 21 Individual Urinalysis Values O CO DuPont-5990 Company Sanitized. Does not contain TSCA CBI )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________ Animal Number VOL UOSM mL mOsm/kg SG Male, Group: I ~ 0 mg/kg - Day 183 646325 646396 646468 646495 7.2 8.8 22.4 7.2 1601 1063 569 1123 1.045 1.032 1.017 1.031 Male, Group: III: - 25 mg/kg - Day 183 646368 646436 646438 646449 646453 11.6 9.8 13.8 5.2 3.6 1037 1215 863 1616 2528 1.031 1.035 1.027 1.043 1.074 Male, Group: V - 100 mg/kg - Day 183 646327 646335 646376 646403 17.0 7.9 3.9 6.6 844 1499 1745 1587 1.025 1.042 1.046 1.043 Male, Group: VII: - 500 mg/kg - Day 183 646344 646355 646361 646391 646466 20.2 13.0 7.7 11.4 11.0 707 775 1187 1094 1011 1.022 1.024 1.033 1.030 1.028 Individual Urinalysis Values UFLU Mg UMTP mg/dL 9.8 10.6 13.6 6.6 12.3 16.7 16.6 9.9 11.9 25.5 23.6 15.6 21.3 47.3 45.2 46.3 53.9 41.5 131 61 23 27 56 53 47 59 1100 53 148 82 210 19 26 57 59 84 -775 - ) DuPont-5990 )> H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Animal Number QUAL COL CLAR Female, Group : II - 0 mg/kg - Day 40 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 LIGHT LIGHT LIGHT LIGHT MEDIUM NT LIGHT LIGHT MEDIUM LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW NT YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLOUDY CLEAR NT CLEAR CLEAR CLEAR HAZY Female, Group : IV - 25 mg/kg - Day 40 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT MEDIUM LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLEAR CLEAR HAZY CLEAR CLEAR CLEAR CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/ kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 3.4 14.0 6.2 4.1 1.7 QNS 13.8 9.8 4.2 10.0 6.6 6.1 6.5 14.2 1.8 10.0 6.3 2.5 11.2 6.4 1289 479 747 1098 2365 QNS 548 830 1349 707 1.038 1.015 1.023 1.033 1.063 NT 1.017 1.025 1.038 1.021 927 908 1021 444 2241 712 969 1239 617 1199 1.026 1.026 1.028 1.014 1.060 1.021 1.028 1.037 1.018 1.035 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.0 NEGATIVE NEGATIVE NEGATIVE TRACE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE NT NT NT NT NT 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE Company Sanitized. Does not contain TSCA CBI -776- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number QUAL COL CLAR Female, Group : VI - 100 mg/kg - Day 40 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 LIGHT MEDIUM MEDIUM MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY HAZY CLEAR HAZY CLEAR CLEAR CLEAR HAZY CLEAR Female, Group:: VIII - 500 mg/kg - Day 40 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 LIGHT LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR HAZY CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG PH UGLU mg/dL KET mg/dL UBIL BLD 9.0 5.2 11.8 9.2 15.8 17.0 7.0 7.4 15.0 4.6 38.0 28.0 7.5 37.0 40.0 1.6 28.0 13.6 22.6 14.0 754 1313 731 988 656 471 865 1176 514 789 1.023 1.039 1.022 1.029 1.021 1.014 1.026 1.036 1.016 1.022 279 353 1003 268 198 685 282 769 476 559 1.010 1.012 1.030 1.009 1.007 1.022 1.009 1.024 1.016 1.018 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE Company Sanitized. Does not contain TSCA CBI -777 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number URO EU/dL UMTP mg/dL Female, Group: II - 0 mg /kg - Day 646537 0.2 33 646538 0.2 10 646560 0.2 16 646592 0.2 28 646612 0.2 71 646617 NT QNS 646649 0.2 8 646659 0.2 15 646665 0.2 30 646676 0.2 14 Female, Group: IV - 25i mg/kg - Dai 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 13 16 17 9 68 14 17 34 12 27 Individual Urinalysis Values DuPont-5990 Company Sanitized. Does not contain TSCA CBI -778 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number URO EU/dL UMTP mg/dL SPEC Female, Group: VI - 100 mg/kg - Day 40 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 22 56 12 27 26 7 20 29 9 12 ale, Group: VIII - 500 mg/kg Day 40 646509 0.2 <6 646535 0.2 <6 646536 0.2 136 646577 0.2 <6 646593 0.2 <6 646609 0.2 11 646610 0.2 <6 646614 0.2 12 646657 0.2 11 646669 0.2 10 Individual Urinalysis Values DuPont-5990 Company Sanitized. Does not contain TSCA CBI -779 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________ ) DuPont-5990 Animal Number QUAL COL CLAR Female, Group : II - 0 mg/kg - Day 96 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 LIGHT MEDIUM LIGHT LIGHT LIGHT DARK LIGHT LIGHT MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR HAZY CLEAR CLEAR CLEAR CLOUDY CLEAR CLEAR CLEAR CLEAR Female, Group:: IV - 25 mg /kg - Day 96 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 LIGHT MEDIUM NT MEDIUM LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT YELLOW YELLOW NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR NT CLOUDY CLEAR HAZY CLEAR CLEAR CLEAR CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 5.5 2.9 4.3 9.8 8.0 2.0 6.0 5.2 1.6 2.0 18.2 5.6 QNS 7.2 4.7 20.8 5.4 3.0 9.0 8.3 1017 1701 999 627 845 1781 847 1061 RNV 1721 1.031 1.052 1.030 1.020 1.025 1.055 1.026 1.033 1.078 1.051 431 1247 QNS 780 1051 442 957 1638 754 1010 1.015 1.040 NT 1.024 1.031 1.015 1.030 1.049 1.023 1.029 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 5 SMALL MODERATE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE 5 SMALL NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE NT NT NT NT NT 8.0 NEGATIVE NEGATIVE NEGATIVE MODERATE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE Company Sanitized. Does not contain TSCA C8I -780- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations > ) DuPont-5990 Animal Number QUAL COL CLAR Female, Group : VI - 100 mg/kg - Day 96 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 MEDIUM MEDIUM MEDIUM MEDIUM LIGHT LIGHT MEDIUM LIGHT MEDIUM LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR HAZY CLEAR CLEAR CLEAR Female, Group : VIII - 500 mg/kg - Day 96 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 LIGHT LIGHT MEDIUM DARK LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT YELLOW YELLOW YELLOW BROWN YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR HAZY CLOUDY CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/ kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 6.5 4.9 2.8 3.9 28.0 6.4 10.2 6.4 4.6 4.6 16.6 22.0 12.2 8.0 15.4 25.0 19.0 8.6 20.8 17.4 1140 1599 1828 1571 404 776 687 1241 1141 1269 1.042 1.056 1.055 1.050 1.016 1.024 1.022 1.038 1.036 1.039 460 1.018 576 1.021 880 1.036 596 1.019 607 1.022 398 1.015 524 1.018 919 1.030 470 1.018 519 1.017 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE TRACE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.0 NEGATIVE NEGATIVE SMALL LARGE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE TRACE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE Company Sanitized. Does not contain TSCA CBI -781 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number URO EU/dL UFLU MU UMTP mg/dL Female, Group: II - 0 mg/kg - Day 96 646537 0.2 5.8 26 646538 0.2 5.4 69 646560 0.2 5.7 16 646592 0.2 5.9 11 646612 0.2 8.1 17 646617 0.2 2.2 141 646649 0.2 7.0 14 646659 0.2 6.4 21 646665 0.2 QNS 85 646676 0.2 3.4 47 Female, Group: IV - 25 mg/kg - Day 96 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 0.2 32.5 0.2 21.1 NT QNS 0.2 18.6 0.2 18.7 0.2 36.4 0.2 20.9 0.2 11.5 0.2 29.1 0.2 24.4 <6 16 QNS 36 110 18 19 79 14 14 Individual Urinalysis Values SPEC FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED DuPont-5990 Company Sanitized. Does not contain TSCA CBI -782- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Aniinal Number URO EU/dL UFLU Mg UMTP mg/dL Female, Group: VI - 100 mg/kg - Day 96 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 0.2 70.7 950 0.2 67.7 1490 0.2 38.2 108 0.2 57.0 56 0.2 92.9 31 0.2 45.2 12 0.2 68.7 24 0.2 56.1 62 0.2 46.6 17 0.2 50.4 28 Female, Group: VIII - 500 mg/kg -- Day 96 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 0.2 233.1 0.2 402.2 0.2 366.1 1.0 108.0 0.2 286.1 0.2 394.3 0.2 229.3 0.2 229.8 0.2 384.9 0.2 277.7 9 15 1360 102 10 <6 6 33 99 11 Individual Urinalysis Values SPEC FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI - 783 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Animal Number QUAL COL CLAK Female, Group:: II - 0 mg /kg - Day 124 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLOUDY HAZY CLEAR HAZY CLEAR CLEAR CLEAR CLEAR CLEAR Female, Group : VIII - 500 mg/kg - Day 124 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 LIGHT MEDIUM LIGHT LIGHT MEDIUM MEDIUM LIGHT MEDIUM LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLEAR HAZY HAZY CLEAR CLOUDY CLEAR HAZY Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 4.1 920 1.028 8.1 741 1.023 2.4 1946 1.057 3.6 1440 1.044 0.5 QNS >1.083 6.0 948 1.029 1.6 2093 1.060 3.5 1390 1.043 3.3 1644 1.049 7.4 1003 1.030 5.9 1019 1.031 0.5 QNS >1.083 1.8 2262 1.063 4.1 1548 1.060 2.4 1841 1.057 4.0 1603 1.050 0.7 QNS 1.080 1.2 3307 1.082 RNV QNS 1.026 3.2 1261 1.041 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE SMALL SMALL 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE Company Sanitized. Does not contain TSCA C8I -784- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number URO EU/dL UFLU mu UMTP mg/dL Female, Group: II - 0 mg/kg - Day 124 646511 0.2 3.7 19 646549 0.2 2.6 39 646551 0.2 QNS 77 646565 0.2 3.5 30 646580 0.2 QNS QNS 646581 0.2 5.7 17 646586 0.2 QNS 81 646613 0.2 5.6 35 646627 0.2 3.2 41 646652 0.2 5.4 34 Female, Group: VIII - 500 mg/kg - Day 124 646506 646508 646540 646542 646545 646548 646599 646618 0.2 27.5 30 0.2 QNS QNS 0.2 QNS 71 0.2 43.7 2376 0.2 QNS 190 0.2 18.0 164 0.2 QNS 591 0.2 QNS 804 646637 646650 0.2 QNS 0.2 30.7 QNS 77 Individual Urinalysis Values SPEC Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME; FECAL CONTAMINATION OBSERVED Sample status: PARTIAL VOLUME / ACCIDENTAL SPILLAGE DuPont-5990 Company Sanitized. Does not contain TSCA CBI -785 - Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number VOL UOSM mL mOsm/ kg SG Female, Group: II - 0 mg/kg - Day 183 646507 646530 646588 646597 3.1 1120 1.030 6.3 954 1.026 6.0 896 1.025 6.3 914 1.026 Female, Group: IV - 25 mg/kg - Day 183 646531 646568 646625 646626 646636 10.2 9.1 5.5 5.8 6.7 805 889 1129 1436 833 1.022 1.025 1.030 1.037 1.023 Female, Group: VI - 100 mg/kg - Day 183 646533 646630 646632 646634 646656 12.6 5.7 5.0 6.7 6.7 502 1004 1132 788 1249 1.012 1.036 1.030 1.021 1.036 Female, Group: VIII - 500 mg/kg - Day 183 646523 646528 646601 646620 646667 5.5 13.6 6.8 4.7 4.8 661 722 733 1214 1339 1.019 1.020 1.022 1.032 1.040 Individual Urinalysis Values UFLU 9 UMTP mg/dL 4.2 6.7 6.3 6.3 8.6 10.5 7.1 9.7 6.9 11.4 10.1 7.0 9.1 12.0 10.7 28.1 14.3 14.5 11.0 23 20 17 120 13 55 37 33 13 8 1110 38 31 480 125 12 200 29 420 -786- DuPont-5990 )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________________DuPont-5990 Animal Number EPIT UWBC URBC individual Urine Microscopic Values NCRY MICR SPER SPEC Male, Group: I - 0 mg/kg - Day 39 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 NONE NONE NONE FEW NONE NONE FEW FEW FEW NONE 0 0 0 1-10 11-50 0 1-10 0 0 0 Male, Group: III - 25 mg/kg - Day 39 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 FEW FEW NONE FEW FEW NONE FEW FEW NONE NONE 0 0 0 0 1-10 1-10 1-10 0 0 0 0 FEW FEW 0 FEW FEW 0 FEW FEW 0 FEW FEW 0 FEW MODERATE 0 FEW FEW 0 FEW FEW 0 FEW MODERATE 0 FEW MODERATE 0 FEW FEW 0 MODERATE FEW 0 FEW FEW 0 FEW MODERATE 0 MODERATE MODERATE 0 NONE FEW 0 FEW MODERATE 0 MODERATE FEW 0 FEW FEW 0 FEW FEW 0 FEW MANY 0 1 0 2 0 0 1 1 0 1 1 3 1 1 1 2 3 Sample status: BELOW RECOMMENDED VOLUME 1 1 1 Company Sanitized. Does not contain TSCA CBI -787 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations > Animal Number EPIT UWBC URBC Individual Urine Microscopic NCRY MICR SPER Male, Group: V - 100 mg/kg - Day 39 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 FEW NONE NONE NONE NONE FEW NONE FEW FEW FEW 1-10 1-10 0 1-10 0 1-10 0 0 0 0 0 0 0 11-50 0 0 0 0 0 0 Male, Group : VII - 500 mg/kg - Day 39 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 NONE FEW NONE NONE FEW FEW FEW NONE FEW FEW 11-50 0 0 1-10 0 0 1-10 0 0 0 0 0 0 0 0 0 0 0 0 0 FEW MODERATE NONE FEW FEW FEW FEW FEW FEW FEW FEW MODERATE NONE FEW FEW FEW FEW FEW FEW NONE FEW MODERATE MODERATE FEW FEW FEW FEW FEW FEW MODERATE, FEW FEW FEW FEW FEW MODERATE FEW MODERATE MODERATE FEW 1 1 2 2 1 3 1 3 1 1 1 2 1 2 0 1 0 2 1 1 Company Sanitized. Does not contain TSCA CBI -788 - Values SPEC DuPont-5990 Sample status: BELOW RECOMMENDED VOLUME Sample status: BELOW RECOMMENDED VOLUME H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Animal Number EPIT UWBC URBC Individual Urine Microscopic Values NCRY MICR SPER SPEC Male, Group: I - 0 mg/kg - Day 95 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 NONE FEW NONE NONE MODERATE FEW NONE NONE NONE NONE 0 1-10 0 1-10 >50 1-10 1-10 0 0 0 0 FEW FEW 0 NONE FEW 0 FEW FEW 0 NONE NONE >50 NONE MODERATE 0 FEW FEW 0 FEW FEW 0 MANY FEW 0 FEW FEW 0 FEW FEW Male, Group : III - 25 mg/kg - Day 95 646370 646399 646414 646421 646423 646426 646443 646454 646458 646471 NONE FEW FEW FEW FEW FEW FEW NONE NONE NONE 0 0 1-10 0 0 >50 0 0 0 0 0 MODERATE FEW 0 FEW MODERATE 0 MODERATE FEW 0 NONE FEW 0 FEW FEW 0 MODERATE MODERATE 0 FEW FEW 0 FEW FEW 0 MANY MANY 0 NONE MODERATE i i Sample status: BELOW RECOMMENDED VOLUME i Sample status: BELOW RECOMMENDED VOLUME; 1-MUCUS 3 3 3 1 Sample status: BELOW RECOMMENDED VOLUME 1 Sample status: BELOW RECOMMENDED VOLUME 2 1 2 1 1 Sample status: BELOW RECOMMENDED VOLUME 1 1 Sample status: BELOW RECOMMENDED VOLUME 3 2 1 2 Sample status: BELOW RECOMMENDED VOLUME 1 Company Sanitized. Does not contain TSCA CBI -789- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Animal Number EPIT UWBC URBC Individual Urine Microscopic NCRY MICR SPER Male, Group: V - 100 mg/kg - Day 95 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 NONE FEW FEW FEW FEW NONE FEW FEW NONE FEW 0 1-10 0 0 0 0 0 0 11-50 1-10 0 FEW 0 FEW 0 NONE 0 FEW 0 NONE 0 FEW 0 MODERATE 0 FEW 0 FEW 0 NONE FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW i 3 3 1 1 1 1 2 1 3 Male, Group: VII - 500 mg/kg - Day 95 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 FEW NONE NONE NONE NONE NONE FEW FEW FEW FEW 1--10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NONE FEW NONE FEW FEW NONE FEW NONE NONE FEW FEW MODERATE FEW FEW FEW MODERATE MANY FEW FEW MODERATE 3 1 1 1 1 2 1 3 2 1 Company Sanitized. Does not contain TSCA CBI -790- Values SPEC DuPont-5990 Saitple status : BELOW RECOMMENDED VOLUME Sample status : BELOW RECOMMENDED VOLUME Sample status : BELOW RECOMMENDED VOLUME Sample status : BELOW RECOMMENDED VOLUME Sample status : BELOW RECOMMENDED VOLUME Sample status: BELOW RECOMMENDED VOLUME; FEW COARSELY GRANULAR CASTS ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5990 Animal Number EPIT UWBC URBC Individual Urine Microscopic Values NCRY MICR SPER SPEC Male, Group: I - 0 mg/kg -- Day 123 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 NONE FEW NONE FEW FEW NONE FEW NONE FEW FEW 0 0 1-10 1-10 0 1-10 1-10 1-10 0 0 0 0 0 0 0 0 0 0 0 0 Male, Group: VII - 500 mg/kg - Day 123 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 FEW FEW FEW FEW NONE FEW FEW FEW FEW FEW 0 1-10 0 1-10 1-10 0 0 0 0 0 0 0 0 0 0 0 0 0 1-10 0 MANY NONE FEW NONE FEW MANY FEW FEW MANY MODERATE MANY NONE FEW NONE NONE NONE NONE NONE NONE NONE FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW MODERATE FEW FEW FEW FEW FEW FEW FEW FEW MODERATE 0 Sample status: BELOW RECOMMENDED VOLUME 0 1 3 Sample status: BELOW RECOMMENDED VOLUME 1 3 0 3 1 Sample status: BELOW RECOMMENDED VOLUME 3 3 3 2 3 3 2 3 1 3 Sample status: BELOW RECOMMENDED VOLUME 3 Company Sanitized. Does not contain TSCA CBI -791 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number EPIT UWBC URBC Individual Urine Microscopic NCRY MICR SPER Female, Group: II - 0 mg/kg - Day 40 646537 646538 646560 646592 646612 646649 646659 646665 646676 NONE NONE FEW FEW FEW FEW NONE FEW NONE 00 00 00 00 00 00 00 0 1-10 00 Female, Group: IV - 25 mg/kg - Day 40 646502 646522 646567 646576 646595 646621 646635 646660 646664 646673 FEW 0 0 FEW 0 0 FEW 0 0 FEW 0 0 FEW 1-10 1-10 FEW 0 1-10 FEW 0 0 FEW 0 0 FEW 0 0 FEW 0 0 FEW NONE FEW MODERATE NONE FEW NONE NONE FEW FEW FEW NONE NONE FEW NONE NONE NONE FEW FEW MODERATE MANY MANY MANY MODERATE MANY MANY MODERATE MANY MANY MANY MANY FEW MODERATE MANY MANY MODERATE MANY MODERATE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Company Sanitized. Does not contain TSCA CBI -792- Values SPEC DuPont-5990 Sample status : BELOW RECOMMENDED VOLUME Sample status : BELOW RECOMMENDED VOLUME; 1-MUCUS Sample status : BELOW RECOMMENDED VOLUME; 1-MUCUS Sample status : BELOW RECOMMENDED VOLUME; 1-MUCUS FEW FINELY GRANULAR CASTS Sample status; BELOW RECOMMENDED VOLUME 1-MUCUS 1-MUCUS 1-MUCUS 1-MUCUS 1-MUCUS Sample status: BELOW RECOMMENDED VOLUME; 2 -MUCUS 1-MUCUS 3-MUCUS; FEW SMALL COARSELY GRANULAR CASTS sample status: BELOW RECOMMENDED VOLUME; 2-MUCUS 1 -MUCUS 1 -MUCUS H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number EPIT UWBC URBC Female, Group: VI - 100 mg/kg - Day 40 646501 FEW 0 0 646505 FEW 0 0 646510 FEW 0 0 646534 FEW 0 0 646556 FEW 0 0 646578 FEW 0 0 646608 NONE 00 646624 FEW 0 0 646629 FEW 0 0 646633 FEW 0 0 Female, Group: VIII - 500 mg/kg - Day 40 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 FEW FEW FEW FEW FEW NONE NONE FEW FEW FEW 0 0 1-10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1-10 0 0 Individual Urine Microscopic NCRY MICR SPER FEW FEW NONE NONE NONE NONE FEW NONE NONE FEW MANY MANY MODERATE MANY MANY MANY MODERATE MODERATE MANY MANY FEW NONE NONE NONE NONE NONE NONE NONE NONE FEW MANY MANY MODERATE MANY MANY MANY MANY MANY MANY MANY . 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Company Sanitized. Does not contain TSCA CBI -793 - Values SPEC DuPont-5990 2-MUCUS Sample status: 1- MUCUS 2- MUCUS 1-MUCUS 3- MUCUS 1-MUCUS 1-MUCUS 1-MUCUS 3-MUCUS BELOW RECOMMENDED VOLUME; 1-MUCUS 2 -MUCUS 2-MUCUS 1 -MUCUS 1-MUCUS Sample status: BELOW RECOMMENDED VOLUME; 2-MUCUS 1- MUCUS 2- MUCUS 1-MUCUS )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________________________________ ) DuPont-5990 Animal Number EPIT UWBC URBC Female, Group: II - 0 mg/kg - Day 96 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 FEW FEW FEW FEW FEW FEW NONE FEW FEW FEW 0 0 0 0 0 0 0 0 0 1-10 Female, Group: IV - 25 mg/kg - Day 96 646502 646522 646567 646576 646595 646621 646635 646660 FEW 0 FEW 1-10 NT FEW 1-10 FEW 1-10 FEW 0 FEW ' 0 FEW 0 646664 646673 FEW FEW 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Individual Urine Microscopic Values NCRY MICR SPER SPEC NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE FEW NONE FEW FEW MANY FEW FEW FEW FEW FEW FEW MANY FEW NONE FEW FEW NONE FEW 0 0 Sample status : BELOW RECOMMENDED VOLUME 0 Sample status : BELOW RECOMMENDED VOLUME 0 FEW COARSELY GRANULAR CASTS 0 0 Sample status : BELOW RECOMMENDED VOLUME 0 Sample status:: BELOW RECOMMENDED VOLUME 0 Sample status : BELOW RECOMMENDED VOLUME 0 Sample status : BELOW RECOMMENDED VOLUME 0 Sample status : BELOW RECOMMENDED VOLUME 0 0 0 0 0 0 0 Sample status: BELOW RECOMMENDED VOLUME; FEW COARSELY GRANULAR CASTS 0 0 Company Sanitized. Does not contain TSCA CBI -794- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 Animal Number EPIT UWBC URBC Individual Urine Microscopic Values NCRY MICR SPER SPEC Female, Group: VI - 100 mg /kg - Day 96 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 FEW FEW FEW FEW FEW FEW FEW FEW FEW NONE 0 0 1-10 0 1-10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Female, Group: VIII - 500 mg/kg - Day 96 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 FEW 0 FEW 0 FEW 0 FEW 0 FEW 0 FEW 1-10 FEW 1-10 FEW 0 FEW 1-10 FEW 0 0 0 0 0 0 0 0 0 0 0 NONE NONE FEW NONE NONE NONE FEW NONE NONE NONE NONE NONE NONE MODERATE NONE NONE NONE NONE NONE NONE NONE FEW MODERATE NONE FEW FEW FEW NONE FEW FEW FEW NONE FEW MANY FEW MODERATE FEW FEW FEW NONE 0 0 FEW HYALINE CASTS 0 0 0 0 0 0 0 0 Sample status: BELOW RECOMMENDED VOLUME 0 0 0 FEW COARSELY GRANULAR CASTS 0 0 0 0 0 0 0 Company Sanitized. Does not contain TSCA O CD )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Animal Number EPIT UWBC URBC Female, Group: II - 0 mg/kg - Day 124 646511 646549 646551 646565 646580 FEW 0 FEW 0 FEW 1-10 FEW 1-10 FEW 0 0 0 0 0 0 646581 646586 646613 646627 646652 FEW FEW NONE FEW FEW 0 0 1-10 0 0 0 0 0 0 0 Female, Group: VIII - 500 mg/kg - Day 124 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 FEW FEW MODERATE FEW FEW FEW FEW FEW FEW FEW 0 1-10 0 1-10 0 0 0 0 0 1-10 0 0 0 0 0 0 0 0 0 0 Individual Urine Microscopic NCRY MICR SPER FEW NONE FEW NONE NONE FEW MANY MODERATE FEW MODERATE NONE NONE NONE NONE NONE FEW FEW FEW FEW FEW NONE NONE FEW NONE NONE NONE NONE FEW FEW NONE FEW FEW FEW FEW NONE FEW FEW MANY FEW FEW 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Company Sanitized. Does not contain TSCA CBI -796- Values SPEC ) DuPont-5990 Sample status: BELOW RECOMMENDED VOLUME Sample status: BELOW RECOMMENDED VOLUME Sample status: BELOW RECOMMENDED VOLUME Sanple status: BELOW RECOMMENDED VOLUME; FEW COARSELY GRANULAR CASTS ;VARIABLE SIZED (4.5-7 MICRONS PER; 401I) TAN SPHEROCYTE Sample status Sample status Sample status BELOW RECOMMENDED VOLUME BELOW RECOMMENDED VOLUME BELOW RECOMMENDED VOLUME Sample status: BELOW RECOMMENDED VOLUME Sample status: BELOW RECOMMENDED VOLUME FEW COARSELY GRANULAR CASTS Sanple status Sample status Sample status Sample status BELOW RECOMMENDED VOLUME BELOW RECOMMENDED VOLUME BELOW RECOMMENDED VOLUME BELOW RECOMMENDED VOLUME H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 APPENDIX L INDIVIDUAL BIOCHEMICAL MEASUREMENTS -797Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BIOCHEMICAL MEASUREMENTS IN MALE RATS AT THE 10-DAY TIME POINT Group I III V vn Animal Number 648938 648939 648940 648941 648942 648943 648944 648945 648946 648947 648948 648949 648950 648951 648952 648953 648954 648955 648956 648957 Beta-Oxidation Rate (nmol/min/mg protein) 3.3 1.6 3.7 4.1 5.0 4.7 3.8 3.8 5.1 3.2 5.5 3.3 6.2 7.5 7.5 2.8 12.8 12.4 13.5 8.7 -798Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BIOCHEMICAL MEASUREMENTS IN MALE RATS AT THE 90-DAY TIME POINT Group I m V vn Animal Number 646482 646427 646360 646489 646379 646454 646399 646370 646443 646423 646349 646463 646456 646469 646472 646475 646388 646346 646433 646407 Beta-Oxidation Rate (nmol/min/mg protein) 8.0 8.1 9.5 7.2 12.2 10.9 15.1 12.3 12.4 11.5 10.5 11.3 15.5 10.1 9.0 14.2 16.7 15.8 16.4 18.2 -799Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BIOCHEMICAL MEASUREMENTS IN MALE RATS AT THE 1-MONTH RECOVERY TIME POINT Group I vn Animal Number 646459 646460 646416 646371 646411 646364 646384 646474 646448 646484 Beta-Oxidation Rate (nmol/min/mg protein) 7.2 6.3 5.8 6.2 6.6 14.9 11.1 10.0 12.2 14.4 INDIVIDUAL BIOCHEMICAL MEASUREMENTS IN MALE RATS AT THE 3-MONTH RECOVERY TIME POINT Group I vn Animal Number 646325 646396 646495 646468 646355 646344 646361 646391 646466 Beta-Oxidation Rate (nmol/min/mg protein) 17.6 19.2 17.6 19.6 20.7 18.3 20.0 17.9 17.2 - 800Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BIOCHEMICAL MEASUREMENTS IN FEMALE RATS RATS AT THE 10-DAY TIME POINT Group n IV VI vm Animal Number 648960 648961 648962 648963 648964 648965 648966 648967 648968 648969 648970 648971 648972 648973 648974 648975 648976 648977 648978 648979 Beta-Oxidation Rate (nmol/min/mg protein) 4.6 6.5 5.6 6.4 4.5 5.5 5.2 4.3 9.7 9.6 5.2 3.4 3.8 4.8 4.4 4.5 5.8 4.1 4.6 6.3 - 801 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BIOCHEMICAL MEASUREMENTS IN FEMALE RATS RATS AT THE 90-DAY TIME POINT Group n IV VI vm Animal Number 646592 646560 646676 646665 646612 646522 646660 646502 646595 646567 646608 646556 646629 646510 646578 646657 646610 646536 646593 646509 Beta-Oxidation Rate (nmol/min/mg protein) 15.8 14.5 13.2 7.9 13.0 9.6 6.4 6.2 10.8 7.3 9.0 12.6 7.6 14.3 10.8 14.7 15.7 10.2 14.1 12.4 -802Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL BIOCHEMICAL MEASUREMENTS IN FEMALE RATS AT THE 1-MONTH RECOVERY TIME POINT Group n vm Animal Number 646580 646581 646627 646565 646551 646540 646548 646508 646650 646637 Beta-Oxidation Rate (nmol/min/mg protein) 10.5 8.2 9.1 11.2 10.4 13.3 11.2 15.9 11.2 13.5 -803Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 APPENDIX M INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - 804Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION DuPont-5990 Organ Weight Listing Group : I - 0 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW (Gms) 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 655.70 526.80 663.70 588.60 607.50 535.10 515.20 532.20 622.00 622.90 BRAIN (Gms) %FBW 2.116 0.3227 2.158 0.4096 2.050 0.3089 2.104 0.3575 2.080 0.3424 2.225 0.4158 2.040 0.3960 2.033 0.3820 2.321 0.3732 2.193 0.3521 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.051 0.0078 2.4102 0.061 0.0116 2.8267 0.059 0.0089 2.8780 0.065 0.0110 3.0894 0.050 0.0082 2.4038 0.044 0.0082 1.9775 0.066 0.0128 3.2353 0.045 0.0085 2.2135 0.066 0.0106 2.8436 0.063 0.0101 2.8728 Mean S.D. 586.97 2.132 0.3660 55.792 0.093 0.0358 0.057 0.0098 2.6751 0.009 0.0017 0.4028 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.262 0.1925 59.641 1.506 0.2859 69.787 1.687 0.2542 82.293 1.418 0.2409 67.395 1.730 0.2848 83.173 1.552 0.2900 69.753 1.657 0.3216 81.225 1.475 0.2772 72.553 1.753 0.2818 75.528 1.531 0.2458 69.813 1.557 0.2675 73.116 0.153 0.0355 7.4897 HEART (Gms) %FBW %BRAIN 2.022 0.3084 95.558 1.868 0.3546 86.562 1.853 0.2792 90.390 1.750 0.2973 83.175 1.811 0.2981 87.067 1.743 0.3257 78.337 1.821 0.3535 89.265 1.623 0.3050 79.833 2.010 0.3232 86.601 1.755 0.2817 80.027 1.826 0.3127 85.681 0.122 0.0265 5.4005 KIDNEYS 1 (Gms) %FBW %BRAIN | 4.531 0.6910 214.13 3.939 0.7477 182.53 4.608 0.6943 224.78 3.954 0.6718 187.93 5.521 0.9088 265.43 3.779 0.7062 169.84 3.923 0.7615 192.30 3.871 0.7274 190.41 4.240 0.6817 182.68 4.364 0.7006 199.00 4.273 0.7291 200.90 0.526 0.0693 27.688 Group : III - 25 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW (Gms) 646370 646399 646414 646421 646423 646426 646443 646454 543.40 694.10 589.40 546.70 577.00 577.50 600.30 539.20 BRAIN (Gms) %FBW 2.107 0.3877 2.118 0.3051 2.271 0.3853 2.159 0.3949 2.155 0.3735 2.078 0.3598 2.155 0.3590 2.207 0.4093 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.044 0.0081 2.0883 0.061 0.0088 2.8801 0.062 0.0105 2.7301 0.053 0.0097 2.4548 0.048 0.0083 2.2274 0.057 0.0099 2.7430 0.044 0.0073 2.0418 0.053 0.0098 2.4014 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.765 0.3248 83.768 1.622 0.2337 76.582 1.371 0.2326 60.370 1.419 0.2596 65.725 1.704 0.2953 79.072 1.598 0.2767 76.901 1.767 0.2944 81.995 1.666 0.3090 75.487 (Gms) HEART %FBW %BRAIN KIDNEYS I (Gms) %FBW %BRAIN | 2.185 0.4021 103.70 1.979 0.2851 93.437 1.985 0.3368 87.406 1.755 0.3210 81.288 1.839 0.3187 85.336 1.817 0.3146 87.440 2.224 0.3705 103.20 1.739 0.3225 78.795' 4.176 0.7685 198.20 4.154 0.5985 196.13 4.326 0.7340 190.49 4.073 0.7450 188.65 4.009 0.6948 186.03 4.719 0.8171 227.09 4.479 0.7461 207.84 4.333 0.8036 196.33 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -805 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION DuPont-5990 Organ Weight Listing Group : III - 25 mg/kg/day Sex :MALES 1 ANIMAL 1 1 646458 1 646471 11 1 Mean 1 S.D. FBW (Gms) 584.80 695.70 594.81 56.631 BRAIN (Gms) %FBW 2.194 0.3752 2.190 0.3148 2.163 0.3665 0.056 0.0335 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.053 0.0091 2.4157 0.076 0.0109 3.4703 0.055 0.0092 2.5453 0.010 0.0011 0.4282 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.417 0.2423 64.585 1.455 0.2091 66.438 1.578 0.2677 73.092 0.151 0.0381 8.1254 HEART (Gms) %FBW %BRAIN 1.642 0.2808 74.840 2.057 0.2957 93.927 1.922 0.3248 88.937 0.195 0.0376 9.6855 KIDNEYS | (Gms) %FBW %BRAIN | 4.140 0.7079 188.70 4.701 0.6757 214.66 4.311 0.7291 199.41 0.251 0.0641 13.253 Group : V - 100 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW (Gms) 646349 646373 646385 646435 646455 6464b6 646463 646469 646472 646488 522.40 626.30 543.40 545.70 501.40 528.70 454.00 515.30 451.50 523.70 BRAIN (Gms) %FBW 2.003 0.3834 2.206 0.3522 2.077 0.3822 2.194 0.4021 2.073 0.4134 1.964 0.3715 2.152 0.4740 2.014 0.3908 2.051 0.4543 1.981 0.3783 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.048 0.0092 2.3964 0.056 0.0089 2.5385 0.047 0.0086 2.2629 0.047 0.0086 2.1422 0.054 0.0108 2.6049 0.047 0.0089 2.3931 0.068 0.0150 3.1599 0.039 0.0076 1.9364 0.051 0.0113 2.4866 0.049 0.0094 2.4735 Mean S.D. 521.24 2.072 0.4002 49.446 0.087 0.0378 0.051 0.0098 2.4394 0.008 0.0021 0.3225 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.238 0.2370 61.807 1.519 0.2425 68.858 1.628 0.2996 78.382 1.249 0.2289 56.928 1.550 0.3091 74.771 1.530 0.2894 77.902 1.595 0.3513 74.117 1.488 0.2888 73.883 1.532 0.3393 74.695 1.785 0.3408 90.106 1.511 0.2927 73.145 0.164 0.0447 9.1542 HEART (Gms) %FBW %BRAIN 1.667 0.3191 83.225 1.920 0.3066 87.035 1.707 0.3141 82.186 1.612 0.2954 73.473 1.715 0.3420 82.730 1.611 0.3047 82.026 1.497 0.3297 69.563 1.714 0.3326 85.104 2.005 0.4441 97.757 1.794 0.3426 90.560 1.724 0.3331 83.366 0.150 0.0421 7.9397 KIDNEYS ) (Gms) %FBW %BRAIN | 3.751 0.7180 187.27 5.456 0.8711 247.33 4.629 0.8519 222.87 4.238 0.7766 193.16 4.383 0.8742 211.43 4.300 0.8133 218.94 3.708 0.8167 172.30 4.141 0.8036 205.61 3.673 0.8135 179.08 4.212 0.8043 212.62 4.249 0.8143 205.06 0.528 0.0461 22.608 Company Sanitized. Does not contain TSCA FBW - Final Body Weight aO ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Organ Weight Listing ) DuPont-5990 Group : VII - 500 mg/kg/day Sex :MALES 1 ANIMAL FBW BRAIN (Gms) (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 473.80 507.00 411.60 527.40 514.90 415.00 406.20 441.20 414.70 446.50 2.092 0.4415 2.036 0.4016 2.101 0.5104 2.079 0.3942 2.115 0.4108 2.146 0.5171 2.011 0.4951 2.087 0.4730 2.029 0.4893 2.101 0.4705 0.044 0.0093 2.1033 0.045 0.0089 2.2102 0.061 0.0148 2.9034 0.051 0.0097 2.4531 0.057 0.0111 2.6950 0.055 0.0133 2.5629 0.045 0.0111 2.2377 0.047 0.0107 2.2520 0.046 0.0111 2.2671 0.036 0.0081 1.7135 Mean S.D. 455.83 2.080 0.4604 46.705 0.042 0.0456 0.049 0.0108 2.3398 0.007 0.0020 0.3325 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.349 0.2847 64.484 1.343 0.2649 65.963 1.545 0.3754 73.536 1.293 0.2452 62.193 1.358 0.2637 64.208 1.438 0.3465 67.008 1.349 0.3321 67.081 1.282 0.2906 61.428 1.301 0.3137 64.120 1.218 0.2728 57.972 1.348 0.2990 64.799 0.090 0.0417 4.1292 HEART (Gms) %FBW %BRAIN 1.405 0.2965 67.161 1.653 0.3260 81.189 1.308 0.3178 62.256 1.527 0.2895 73.449 1.545 0.3001 73.050 1.416 0.3412 65.983 1.179 0.2903 58.628 1.197 0.2713 57.355 1.188 0.2865 58.551 1.528 0.3422 72.727 1.395 0.3061 67.035 0.170 0.0243 7.9608 KIDNEYS (Gms) %FBW %BRAIN 4.381 0.9247 209.42 3.951 0.7793 194.06 4.046 0.9830 192.57 4.576 0.8677 220.11 4.623 0.8978 218.58 3.893 0.9381 181.41 3.344 0.8232 166.29 3.531 0.8003 169.19 3.579 0.8630 176.39 4.160 0.9317 198.00 4.008 0.8809 192.60 0.439 0.0659 19.362 Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight - 807 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION DuPont-5990 Organ Weight Listing Group : I- 0 mg/kg/day Sex :MALES 1 ANIMAL 1 646360 646367 646374 646379 646420 646427 646482 646485 646489 646492 LIVER (Gms) %FBW %BRAIN 16.813 2.5641 794.57 12.462 2.3656 577.48 22.364 3.3696 1090.9 16.513 2.8055 784.84 20.268 3.3363 974.42 15.311 2.8613 688.13 15.441 2.9971 756.91 14.617 2.7465 718.99 16.130 2.5932 694.96 16.412 2.6348 748.38 SPLEEN (Gms) %FBW %BRAIN 0.992 0.1513 46.881 0.736 0.1397 34.106 0.941 0.1418 45.902 0.803 0.1364 38.165 1.324 0.2179 63.654 0.907 0.1695 40.764 0.710 0.1378 34.804 0.720 0.1353 35.416 0.814 0.1309 35.071 1.091 0.1751 49.749 TESTES (Gms) %FBW %BRAIN 3.356 0.5118 158.60 3.561 0.6760 165.01 3.662 0.5518 178.63 3.540 0.6014 168.25 3.769 0.6204 181.20 3.472 0.6489 156.04 4.006 0.7776 196.37 3.465 0.6511 170.44 4.229 0.6799 182.21 3.280 0.5266 149.57 THYMUS (Gms) %FBW %BRAIN 0.701 0.1069 33.129 0.258 0.0490 11.956 0.398 0.0600 19.415 0.617 0.1048 29.325 0.302 0.0497 14.519 0.388 0.0725 17.438 0.399 0.0774 19.559 0.389 0.0731 19.134 0.366 0.0588 15.769 0.526 0.0844 23.985 THYROID GLAND | (Gms) %FBW %BRAIN | 0.026 0.0040 1.2287 0.018 0.0034 0.8341 0.031 0.0047 1.5122 0.022 0.0037 1.0456 0.018 0.0030 0.8654 0.019 0.0036 0.8539 0.023 0.0045 1.1275 0.015 0.0028 0.7378 0.022 0.0035 0.9479 0.022 0.0035 1.0032 Mean S.D. 16.633 2.8274 782.96 2.809 0.3273 147.79 0.904 0.1536 42.451 0.194 0.0271 9.3551 3.634 0.6245 170.63 0.295 0.0807 14.185 0.434 0.0737 20.423 0.139 0.0205 6.6158 0.022 0.0037 1.0156 0.005 0.0006 0.2283 Group : III - 25 mg/kg/day Sex :MALES * 1 ANIMAL 1 646370 646399 646414 646421 646423 646426 646443 646454 LIVER (Gms) %FBW %BRAIN 15.950 2.9352 757.00 21.299 3.0686 1005.6 18.773 3.1851 826.64 18.079 3.3069 837.38 17.616 3.0530 817.45 19.112 3.3094 919.73 20.732 3.4536 962.04 16.926 3.1391 766.92 SPLEEN (Gms) %FBW %BRAIN 0.867 0.1596 41.149 0.932 0.1343 44.004 0.930 0.1578 40.951 0.869 0.1590 40.250 0.703 0.1218 32.622 0.747 0.1294 35.948 0.947 0.1578 43.944 0.763 0.1415 34.572 TESTES (Gms) %FBW %BRAIN 3.459 0.6365 164.17 3.586 0.5166 169.31 3.882 0.6586 170.94 3.697 0.6762 171.24 3.513 0.6088 163.02 3.734 0.6466 179.69 3.774 0.6287 175.13 3.837 0.7116 173.86 THYMUS (Gms) %FBW %BRAIN 0.418 0.0769 19.839 0.663 0.0955 31.303 0.470 0.0797 20.696 0.391 0.0715 18.110 0.470 0.0815 21.810 0.198 0.0343 9.5284 0.358 0.0596 16.613 0.369 0.0684 16.720 THYROID GLAND | (Gms) %FBW %BRAIN | 0.021 0.0039 0.9967 0.020 0.0029 0.9443 0.020 0.0034 0.8807 0.020 0.0037 0.9264 0.025 0.0043 1.1601 0.018 0.0031 0.8662 0.026 0.0043 1.2065 0.018 0.0033 0.8156 FBW - Final Body Weight Company Sanitized. Does not contain TSCA O CD H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION DuPont-5990 Organ Weight Listing Group : III - 25 mg/kg/day Sex :MALES 1 ANIMAL (Gms) LIVER %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN TESTES | THYMUS | THYROID GLAND | (Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN | 1 646458 1 646471 1 1 1 Mean 1 S.D. 18.099 3.0949 824.93 23.678 3.4035 1081.2 19.026 3.1949 879.89 2.295 0.1676 107.54 0.903 0.1544 41.158 1.093 0.1571 49.909 0.875 0.1473 40.451 0.115 0.0142 5.0738 3.577 0.6117 163.04 | 0.511 0.0874 23.291 | 0.017 0.0029 0.7748 3.355 0.4822 153.20 | 0.696 0.1000 31.781 | 0.019 0.0027 0.8676 3.641 0.6178 168.36 | 0.454 0.0755 20.969 | 0.020 0.0035 0.9439 0.171 0.0698 7.6352 | 0.147 0.0189 6.7267 j 0.003 0.0006 0.1413 Group : V - 100 mg/kg/day Sex :MALES 1 ANIMAL (Gms) LIVER %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN TESTES (Gms) %FBW %BRAIN THYMUS (Gms) %FBW %BRAIN THYROID GLAND | (Gms) %FBW %BRAIN 646349 646373 646385 646435 646455 646456 646463 646469 646472 646488 22.014 4.2140 1099.1 28.418 4.5374 1288.2 24.648 4.5359 1186.7 21.684 3.9736 988.33 19.233 3.8359 927.79 21.683 4.1012 1104.0 19.800 4.3612 920.07 19.834 3.8490 984.81 18.630 4.1262 908.34 21.685 4.1407 1094.6 0.701 0.1342 34.998 1.074 0.1715 48.685 0.884 0.1627 42.561 0.801 0.1468 36.509 0.846 0.1687 40.810 0.706 0.1335 35.947 0.595 0.1311 27.649 0.879 0.1706 43.644 0.766 0.1697 37.348 0.726 0.1386 36.648 3.133 0.5997 156.42 3.538 0.5649 160.38 3.645 0.6708 175.49 3.166 0.5802 144.30 3.809 0.7597 183.74 3.395 0.6421 172.86 3.927 0.8650 182.48 3.866 0.7502 191.96 3.675 0.8140 179.18 3.949 0.7541 199.34 0.318 0.0609 15.876 0.325 0.0519 14.733 0.292 0.0537 14.059 0.353 0.0647 16.089 0.252 0.0503 12.156 0.278 0.0526 14.155 0.220 0.0485 10.223 0.307 0.0596 15.243 0.335 0.0742 16.333 0.283 0.0540 14.286 0.028 0.0054 1.3979 0.022 0.0035 0.9973 0.022 0.0040 1.0592 0.026 0.0048 1.1851 0.016 0.0032 0.7718 0.024 0.0045 1.2220 0.018 0.0040 0.8364 0.017 0.0033 0.8441 0.026 0.0058 1.2677 0.018 0.0034 0.9086 Mean S.D. 21.763 4.1675 1050.2 2.915 0.2512 125.92 0.798 0.1527 38.480 0.132 0.0174 5.7474 3.610 0.7001 174.62 0.299 0.1033 16.782 0.296 0.0570 14.315 0.040 0.0079 1.8913 0.022 0.0042 1.0490 0.004 0.0009 0.2120 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -809- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION DuPont-5990 Organ Weight Listing Group : VII - 500 mg/kg/day Sex :MALES | ANIMAL | LIVER | SPLEEN | TESTES | THYMUS | THYROID GLAND (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN 646343 646346 646347 646388 646407 646413 646433 646437 646442 646475 33.286 7.0253 1591.1 30.628 6.0410 1504.3 23.979 5.8258 1141.3 33.924 6.4323 1631.7 33.702 6.5453 1593.5 26.863 6.4730 1251.8 21.809 5.3690 1084.5 26.234 5.9461 1257.0 25.458 6.1389 1254.7 29.607 6.6309 1409.2 0.692 0.1461 33.078 0.647 0.1276 31.778 0.616 0.1497 29.319 0.598 0.1134 28.764 0.911 0.1769 43.073 0.640 0.1542 29.823 0.629 0.1548 31.278 0.613 0.1389 29.372 0.570 0.1374 28.093 0.595 0.1333 28.320 3.645 0.7693 174.24 3.396 0.6698 166.80 4.017 0.9759 191.19 3.519 0.6672 169.26 3.489 0.6776 164.96 3.899 0.9395 181.69 3.486 0.8582 173.35 3.470 0.7865 166.27 3.521 0.8490 173.53 3.410 0.7637 162.30 0.296 0.0625 14.149 0.291 0.0574 14.293 0.308 0.0748 14.660 0.348 0.0660 16.739 0.293 0.0569 13.853 0.287 0.0692 13.374 0.265 0.0652 13.178 0.235 0.0533 11.260 0.174 0.0420 8.5757 0.198 0.0443 9.4241 0.021 0.0044 1.0038 0.022 0.0043 1.0806 0.018 0.0044 0.8567 0.020 0.0038 0.9620 0.027 0.0052 1.2766 0.039 0.0094 1.8173 0.026 0.0064 1.2929 0.020 0.0045 0.9583 0.024 0.0058 1.1828 0.020 0.0045 0.9519 Mean S.D. 28.549 6.2428 1371.9 4.313 0.4738 200.20 0.651 0.1432 31.290 0.097 0.0174 4.4400 3.585 0.7957 172.36 0.210 0.1096 8.6991 0.270 0.0592 12.951 0.053 0.0105 2.4942 0.024 0.0053 1.1383 0.006 0.0016 0.2799 Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight -810- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION DuPont-5990 Organ Weight Listing Group : I- 0 mg/kg/day Sex :MALES 1 ANIMAL 1 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 FBW (Gms) 460.20 561.80 762.60 572.00 619.60 570.80 524.70 539.40 560.10 589.70 BRAIN (Gms) %FBW 2.054 0.4463 2.212 0.3937 2.297 0.3012 2.130 0.3724 2.177 0.3514 2.188 0.3833 2.192 0.4178 2.067 0.3832 2.214 0.3953 2.230 0.3782 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.043 0.0093 2.0935 0.044 0.0078 1.9892 0.061 0.0080 2.6556 0.048 0.0084 2.2535 0.054 0.0087 2.4805 0.047 0.0082 2.1481 0.052 0.0099 2.3723 0.052 0.0096 2.5157 0.043 0.0077 1.9422 0.083 0.0141 3.7220 Mean S.D. 576.09 2.176 0.3823 78.022 0.074 0.0385 0.053 0.0092 2.4172 0.012 0.0019 0.5151 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.386 0.3012 67.478 1.353 0.2408 61.166 1.835 0.2406 79.887 1.448 0.2531 67.981 1.731 0.2794 79.513 1.591 0.2787 72.715 1.526 0.2908 69.617 1.338 0.2481 64.732 1.430 0.2553 64.589 1.643 0.2786 73.677 1.528 0.2667 70.135 0.169 0.0217 6.2770 (Gms) HEART %FBW %BRAIN KIDNEYS 1 (Gms) %FBW %BRAIN j 1.567 0.3405 76.290 1.642 0.2923 74.231 2.455 0.3219 106.88 1.834 0.3206 86.103 1.564 0.2524 71.842 1.835 0.3215 83.867 2.030 0.3869 92.609 . 1.712 0.3174 82.825 1.673 0.2987 75.565 1.806 0.3063 80.987 3.079 0.6691 149.90 3.971 0.7068 179.52 5.476 0.7181 238.40 4.257 0.7442 199.86 3.908 0.6307 179.51 3.856 0.6755 176.23 3.457 0.6589 157.71 3.738 0.6930 180.84 4.292 0.7663 193.86 4.107 0.6965 184.17 1.812 0.3158 83.120 0.267 0.0345 10.427 4.014 0.6959 184.00 0.631 0.0404 24.203 Group : VII - 500 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW (Gms) 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 554.00 465.50 456.50 473.30 624.60 524.50 497.30 561.60 475.70 440.40 BRAIN (Gms) %FBW 2.160 0.3899 1.998 0.4292 1.884 0.4127 2.084 0.4403 2.096 0.3356 2.236 0.4263 2.181 0.4386 2.091 0.3723 2.014 0.4234 2.123 0.4821 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.035 0.0063 1.6204 0.056 0.0120 2.8028 0.040 0.0088 2.1231 0.057 0.0120 2.7351 0.056 0.0090 2.6718 0.062 0.0118 2.7728 0.048 0.0097 2.2008 0.052 0.0093 2.4868 0.037 0.0078 1.8371 0.053 0.0120 2.4965 Mean S.D. 507.34 2.087 0.4150 57.968 0.101 0.0406 0.050 0.0099 2.3747 0.009 0.0020 0.4135 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.475 0.2662 68.287 1.334 0.2866 66.767 1.343 0.2942 71.285 1.431 0.3023 68.666 1.558 0.2494 74.332 1.918 0.3657 85.778 1.497 0.3010 68.638 1.542 0.2746 73.745 1.306 0.2745 64.846 1.315 0.2986 61.941 1.472 0.2913 70.428 0.183 0.0312 6.5836 HEART (Gms) %FBW %BRAIN 1.798 0.3245 83.241 1.581 0.3396 79.129 1.752 0.3838 92.994 1.505 0.3180 72.217 2.089 0.3345 99.666 1.838 0.3504 82.200 1.580 0.3177 72.444 1.877 0.3342 89.766 1.751 0.3681 86.941 1.408 0.3197 66.321 1.718 0.3391 82.492 0.201 0.0224 10.317 KIDNEYS 1 (Gms) %FBW %BRAIN | 4.520 0.8159 209.26 3.370 0.7240 168.67 4.024 0.8815 213.59 3.872 0.8181 185.80 4.996 0.7999 238.36 4.792 0.9136 214.31 3.960 0.7963 181.57 4.576 0.8148 218.84 3.608 0.7585 179.15 3.501 0.7950 164.91 4.122 0.8117 197.44 0.567 0.0543 24.553 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -811 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL. ANIMAL FINAL BODY AND ORGAN WEIGHTS FOP. MALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION DuPont-5990 Organ Weight Listing Group : I- 0 mg/kg/day Sex :MALES 1 ANIMAL 1 646371 646398 646411 646416 646432 646446 646459 646460 646487 646494 (Gms) LIVER %FBW %BRAIN 11.013 2.3931 536.17 16.989 3.0240 768.04 21.557 2.8268 938.48 15.395 2.6914 722.77 16.274 2.6265 747.54 14.608 2.5592 667.64 14.915 2.8426 680.43 15.244 2.8261 737.49 16.775 2.9950 757.68 16.428 2.7858 736.68 SPLEEN (Gms) %FBW %BRAIN 0.569 0.1236 27.702 0.744 0.1324 33.635 0.976 0.1280 42.490 0.762 0.1332 35.775 0.715 0.1154 32.843 0.831 0.1456 37.980 0.637 0.1214 29.060 0.855 0.1585 41.364 0.906 0.1618 40.921 0.743 0.1260 33.318 TESTES (Gms) %FBW %BRAIN 3.333 0.7243 162.27 3.161 0.5627 142.90 4.286 0.5620 186.59 3.272 0.5720 153.62 3.774 0.6091 173.36 3.350 0.5869 153.11 3.134 0.5973 142.97 3.343 0.6198 161.73 3.197 0.5708 144.40 3.858 0.6542 173.00 THYMUS (Gms) %FBW %BRAIN 0.388 0.0843 18.890 0.211 0.0376 9.5389 0.427 0.0560 18.589 0.417 0.0729 19.577 0.243 0.0392 11.162 0.196 0.0343 8.9580 0.276 0.0526 12.591 0.342 0.0634 16.546 0.311 0.0555 14.047 0.463 0.0785 20.762 THYROID GLAND 1 (Gms) %FBW %BRAIN | 0.021 0.0046 1.0224 0.037 0.0066 1.6727 0.030 0.0039 1.3061 0.023 0.0040 1.0798 0.021 0.0034 0.9646 0.030 0.0053 1.3711 0.028 0.0053 1.2774 0.023 0.0043 1.1127 0.023 0.0041 1.0388 0.028 0.0047 1.2556 Mean S.D. 15.920 2.7571 729.29 2.616 0.1940 100.03 0.774 0.1346 35.509 0.122 0.0157 5.1256 3.471 0.6059 159.40 0.377 0.0507 14.806 0.327 0.0574 15.066 0.095 0.0174 4.3753 0.026 0.0046 1.2101 0.005 0.0009 0.2127 Group : VII - 500 mg/kg/day Sex :MALES 1 ANIMAL (Gms) LIVER %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN TESTES (Gms) %FBW %BRAIN THYMUS (Gms) %FBW %BRAIN THYROID GLAND I (Gms) %FBW %BRAIN | 646337 646364 646369 646372 646384 646397 646428 646448 646474 646484 21.248 3.8354 983.70 15.292 3.2851 765.37 15.947 3.4933 846.44 17.042 3.6007 817.75 23.594 3.7775 1125.7 23.052 4.3950 1030.9 18.709 3.7621 857.82 22.124 3.9395 1058.1 17.899 3.7627 888.73 17.916 4.0681 843.90 0.642 0.1159 29.722 0.810 0.1740 40.541 0.608 0.1332 32.272 0.702 0.1483 33.685 0.989 0.1583 47.185 0.928 0.1769 41.503 0.636 0.1279 29.161 0.775 0.1380 37.064 0.792 0.1665 39.325 0.644 0.1462 30.334 3.727 0.6727 172.55 3.066 0.6586 153.45 2.934 0.6427 155.73 3.347 0.7072 160.60 3.949 0.6322 188.41 4.427 0.8440 197.99 3.813 0.7667 174.83 3.749 0.6676 179.29 3.754 0.7892 186.40 3.650 0.8288 171.93 0.382 0.0690 17.685 0.353 0.0758 17.668 0.334 0.0732 17.728 0.207 0.0437 9.9328 0.370 0.0592 17.653 0.292 0.0557 13.059 0.333 0.0670 15.268 0.281 0.0500 13.439 0.409 0.0860 20.308 0.216 0.0490 10.174 0.023 0.0042 1.0648 0.026 0.0056 1.3013 0.029 0.0064 1.5393 0.020 0.0042 0.9597 0.027 0.0043 1.2882 0.033 0.0063 1.4758 0.027 0.0054 1.2380 0.029 0.0052 1.3869 0.025 0.0053 1.2413 0.022 0.0050 1.0363 Mean S.D. 19.282 3.7919 921.84 2.998 0.3070 119.31 0.753 0.1485 36.079 0.130 0.0203 6.0154 3.642 0.7210 174.12 0.433 0.0794 14.556 0.318 0.0629 15.291 0.068 0.0135 3.5178 0.026 0.0052 1.2532 0.004 0.0008 0.1891 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -812- ))) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________________DuPont-5990 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR THREE-MONTH RECOVERY EVALUATION Organ Weight Listing Group : I- 0 mg/kg/day Sex :MALES 1 ANIMAL 1 646325 646396 646468 646495 FBW (Gms) 571.40 593.30 663.90 426.20 KIDNEYS (Gms) %FBW 3.842 0.6724 4.269 0.7195 3.694 0.5564 2.495 0.5854 Mean S.D. 563.70 99.803 3.575 0.6334 0.760 0.0757 (Gms) LIVER %FBW 16.674 2.9181 16.446 2.7720 18.286 2.7543 9.347 2.1931 15.188 2.6594 3.979 0.3194 I SPLEEN i(Gms) %FBW 1 0.720 0.1260 1 0.743 0.1252 1 0.704 0.1060 1 0.661 0.1551 1 0.707 0.1281 1 0.035 0.0202 TESTES (Gms) %FBW 3.979 0.6964 3.890 0.6557 3.561 0.5364 3.562 0.8358 3.748 0.6810 0.218 0.1235 THYROID GLAND (Gms) %FBW 0.024 0.0042 0.023 0.0039 0.033 0.0050 0.018 0.0042 0.025 0.0043 0.006 0.0005 | 1 Group : III - 25 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW KIDNEYS 1 1 (Gms) (Gms) %FBW (Gms) LIVER %FBW 646368 1667.70 646436 1631.70 646438 640.30 646449 665.00 646453 550.00 Mean S.D. ! |630.94 47.830 4.183 0.6265 4.228 0.6693 4.882 0.7625 3.163 0.4756 3.804 0.6916 4.052 0.6451 0.630 0.1068 16.655 2.4944 17.155 2.7157 19.025 2.9713 14.094 2.1194 13.897 2.5267 16.165 2.5655 2.170 0.3134 SPLEEN (Gms) %FBW 0.950 0.1423 0.876 0.1387 0.764 0.1193 0.863 0.1298 0.845 0.1536 0.860 0.1367 0.067 0.0130 TESTES (Gms) %FBW 3.766 0.5640 4.005 0.6340 4.672 0.7297 3.413 0.5132 3.284 0.5971 3.828 0.6076 ' 0.551 0.0814 THYROID GLAND (Gms) %FBW 0.032 0.0048 0.021 0.0033 0.037 0.0058 0.019 0.0029 0.017 0.0031 0.025 0.0040 0.009 0.0013 | | FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -813- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR THREE-MONTH RECOVERY EVALUATION Organ Weight Listing Group : V - 100 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW (Gms) 1 646327 I 646335 1 646376 1 646403 11 1 Mean 1 S.D. 577.60 696.00 525.00 593.20 597.95 71.583 KIDNEYS (Gms) %FBW 3.864 0.6690 4.859 0.6981 3.646 0.6945 3.908 0.6588 4.069 0.6801 0.539 0.0192 LIVER (Gms) %FBW 18.645 3.2280 21.135 3.0366 13.461 2.5640 16.672 2.8105 17.478 2.9098 3.241 0.2868 SPLEEN (Gms) %FBW 0.693 0.1200 1.009 0.1450 0.755 0.1438 0.727 0.1226 0.796 0.1328 0.144 0.0134 TESTES (Gms) %FBW 3.821 0.6615 3.426 0.4922 3.195 0.6086 3.672 0.6190 3.529 0.5953 0.276 0.0724 Group : VII - 500 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW (Gms) 646344 646355 646361 646391 646466 615.10 606.90 660.10 542.40 624.00 KIDNEYS (Gms) %FBW 4.299 0.6989 4.541 0.7482 4.077 0.6176 3.753 0.6919 4.033 0.6463 LIVER (Gms) %FBW 17.420 2.8321 18.763 3.0916 18.436 2.7929 17.398 3.2076 19.282 3.0901 Mean S.D. 609.70 42.752 4.141 0.6806 0.296 0.0504 18.260 3.0028 0.833 0.1807 SPLEEN (Gms) %FBW 0.843 0.1371 1.053 0.1735 0.900 0.1363 0.603 0.1112 0.873 0.1399 0.854 0.1396 0.162 0.0222 TESTES (Gms) %FBW 3.960 0.6438 3.117 0.5136 3.732 0.5654 3.894 0.7179 3.418 0.5478 3.624 0.5977 0.352 0.0824 ) DuPont-5990 THYROID GLAND (Gms) %FBW 0.019 0.0033 0.018 0.0026 0.021 0.0040 0.022 0.0037 0.020 0.0034 0.002 0.0006 1 THYROID GLAND (Gms) %FBW 0.036 0.0059 0.028 0.0046 0.026 0.0039 0.028 0.0052 0.020 0.0032 0.028 0.0046 0.006 0.0010 | 1 f b w - Final Body Weight Company Sanitized. Does not contain TSCA CBI -814- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-5990 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Organ Weight Listing Group : II - 0 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW (Gms) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 290.90 328.20 246.00 324.60 283.10 304.60 362.70 326.50 267.60 336.40 BRAIN (Gms) %FBW 2.067 0.7106 1.885 0.5743 1.791 0.7280 2.041 0.6288 1.998 0.7058 1.985 0.6517 1.922 0.5299 1.885 0.5773 1.954 0.7302 2.037 0.6055 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.056 0.0193 2.7092 0.086 0.0262 4.5623 0.044 0.0179 2.4567 0.065 0.0200 3.1847 0.095 0.0336 4.7548 0.055 0.0181 2.7708 0.063 0.0174 3.2778 0.064 0.0196 3.3952 0.095 0.0355 4.8618 0.054 0.0161 2.6510 Mean S.D. 307.06 1.957 0.6442 35.302 0.086 0.0721 0.068 0.0224 3.4624 0.018 0.0070 0.9231 HEART (Gms) %FBW %BRAIN 1.066 0.3664 51.572 1.209 0.3684 64.138 0.922 0.3748 51.480 1.036 0.3192 50.759 1.178 0.4161 58.959 1.144 0.3756 57.632 1.309 0.3609 68.106 1.234 0.3779 65.464 1.253 0.4682 64.125 1.114 0.3312 54.688 1.147 0.3759 58.692 0.116 0.0418 6.4680 KIDNEYS (Gms) %FBW %BRAIN 2.316 0.7961 112.05 2.215 0.6749 117.51 1.850 0.7520 103.29 2.207 0.6799 108.13 2.211 0.7810 110.66 2.635 0.8651 132.75 2.720 0.7499 141.52 2.179 0.6674 115.60 2.507 0.9368 128.30 2.217 0.6590 108.84 2.306 0.7562 117.86 0.254 0.0922 12.335 (Gms) LIVER 1 %FBW %BRAIN 1 9.445 3.2468 456.94 8.947 2.7261 474.64 6.232 2.5333 347.96 8.758 2.6981 429.10 9.351 3.3031 468.02 8.528 2.7997 429.62 10.541 2.9063 548.44 9.014 2.7608 478.20 8.558 3.1981 437.97 10.267 3.0520 504.03 8.964 2.9224 457.49 1.175 0.2634 52.948 Group : IV - 25 mg/kg/day Sex :FEMALES 1 ANIMAL 1 646502 646522 646567 646576 646595 646621 646635 646660 FBW (Gms) 250.30 292.20 327.00 349.80 277.90 348.10 295.60 255.40 BRAIN (Gms) %FBW 1.900 0.7591 1.933 0.6615 2.036 0.6226 1.864 0.5329 1.957 0.7042 2.038 0.5855 1.949 0.6593 1.725 0.6754 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.058 0.0232 3.0526 0.061 0.0209 3.1557 0.081 0.0248 3.9784 0.045 0.0129 2.4142 0.066 0.0237 3.3725 0.077 0.0221 3.7782 0.073 0.0247 3.7455 0 062 0.0243 3.5942 (Gms) HEART %FBW %BRAIN 1.028 0.4107 54.105 1.029 0.3522 53.233 1.285 0.3930 63.114 1.284 0.3671 68.884 1.102 0.3965 56.311 1.173 0.3370 57.556 1.159 0.3921 59.466 1.030 0.4033 59.710 KIDNEYS (Gms) %FBW %BRAIN 1.836 0.7335 96.632 2.126 0.7276 109.98 2.939 0.8988 144.35 2.359 0.6744 126.56 2.523 0.9079 128.92 2.857 0.8207 140.19 2.755 0.9320 141.35 1.979 0.7749 114.72 (Gms) LIVER ! %FBW %BRAIN I 8.494 3.3935 447.05 9.583 3.2796 495.76 12.605 3.8547 619.11 11.467 3.2782 615.18 10.314 3.7114 527.03 10.801 3.1028 529.98 11.804 3.9932 605.64 9.227 3.6128 534.90 FBW - Final Body Weight Company Sanitized. Does not contain TSCA C8I -815- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________________ ) DuPont-5990 INDIVIDUAL. ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Organ Weight Listing Group : IV - 25 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW (Gms) 646664 300.00 646673 263.80 BRAIN (Gms) %FBW 2.022 0.6740 2.129 0.8071 Mean S.D. 296.01 1.955 0.6682 36.058 0.112 0.0791 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.083 0.0277 4.1048 0.104 0.0394 4.8849 0.071 0.0244 3.6081 0.016 0.0066 0.6713 HEART (Gms) %FBW %BRAIN 1.101 0.3670 54.451 1.164 0.4412 54.674 1.136 0.3860 58.151 0.096 0.0306 4.8770 KIDNEYS (Gms) %FBW %BRAIN 2.595 0.8650 128.34 2.745 1.0406 128.93 2.471 0.8375 126.00 0.383 0.1122 15.066 (Gms) LIVER 1 %FBW %BRAIN | 11.497 3.8323 568.60 9.207 3.4901 432.46 10.500 3.5549 537.57 1.348 0.2932 66.194 Group : VI - 100 mg/kg/day Sex :FEMALES ANIMAL | FBW | BRAIN | ADRENAL GLANDS | HEART | KIDNEYS f LIVER | | (Gms) I(Gins) %FBW | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gins) %FBW %BRAIN | (Gms) %FBW %BRAIN j 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 311.00 333.00 310.10 301.10 346.50 302.80 257.00 307.70 280.00 310.50 1.942 0.6244 2.076 0.6234 1.925 0.6208 1.973 0.6553 1.853 0.5348 1.825 0.6027 1.945 0.7568 1.987 0.6458 1.982 0.7079 2.012 0.6480 0.078 0.0251 4.0165 0.096 0.0288 4.6243 0.075 0.0242 3.8961 0.058 0.0193 2.9397 0.072 0.0208 3.8856 0.058 0.0192 3.1781 0.057 0.0222 2.9306 0.057 0.0185 2.8686 0.058 0.0207 2.9263 0.074 0.0238 3.6779 1.468 0.4720 75.592 1.688 0.5069 81.310 1.234 0.3979 64.104 1.203 0.3995 60.973 1.379 0.3980 74.420 1.181 0.3900 64.712 1.037 0.4035 53.316 1.353 0.4397 68.093 1.035 0.3696 52.220 1.208 0.3890 60.040 2.625 0.8441 135.17 3.616 1.0859 174.18 2.913 0.9394 151.32 2.877 0.9555 145.82 3.037 0.8765 163.90 2.608 0.8613 142.90 1.917 0.7459 98.560 2.690 0.8742 135.38 2.553 0.9118 128.81 2.623 0.8448 130.37 17.253 5.5476 888.41 19.133 5.7456 921.63 16.306 5.2583 847.07 12.485 4.1465 632.79 16.180 4.6696 873.18 13.024 4.3012 713.64 11.098 4.3183 570.59 13.775 4.4768 693.26 14.162 5.0579 714.53 14.977 4.8235 744.38 Mean S.D. 305.97 1.952 0.6420 24.823 0.073 0.0595 0.068 0.0223 3.4944 0.013 0.0032 0.6089 1.279 0.4166 65.478 0.200 0.0429 9.5206 2.746 0.8939 140.64 14.839 4.8345 759.95 0.430 0.0892 20.779 2.419 0.5525 117.37 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -816- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations * INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION ) DuPont-5990 Organ Weight Listing Group : VIII - 500 mg/kg/day Sex :FEMALES ANIMAL FBW BRAIN (Gms) (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 299.30 291.80 307.80 251.90 255.30 321.70 288.40 289.00 316.90 268.20 1.921 0.6418 1.956 0.6703 2.019 0.6559 1.930 0.7662 1.858 0.7278 1.904 0.5919 1.863 0.6460 1.873 0.6481 1.905 0.6011 1.909 0.7118 0.070 0.0234 3.6439 0.076 0.0260 3.8855 0.095 0.0309 4.7053 0.067 0.0266 3.4715 0.063 0.0247 3.3907 0.069 0.0214 3.6239 0.064 0.0222 3.4353 0.063 0.0218 3.3636 0.079 0.0249 4.1470 0.068 0.0254 3.5621 Mean S.D. 289.03 1.914 0.6661 24.176 0.048 0.0549 0.071 0.0247 3.7229 0.010 0.0028 0.4215 (Gms) HEART %FBW %BRAIN 1.191 0.3979 61.999 1.127 0.3862 57.618 1.277 0.4149 63.249 0.843 0.3347 43.679 0.946 0.3705 50.915 1.179 0.3665 61.922 1.138 0.3946 61.084 1.076 0.3723 57.448 1.354 0.4273 71.076 1.024 0.3818 53.641 1.116 0.3847 58.263 0.151 0.0262 7.5534 KIDNEYS (Gms) %FBW %BRAIN 2.614 0.8734 136.07 2.628 0.9006 134.36 3.882 1.2612 192.27 2.245 0.8912 116.32 2.293 0.8982 123.41 2.868 0.8915 150.63 2.547 0.8831 136.71 2.511 0.8689 134.06 3.468 1.0944 182.05 2.198 0.8195 115.14 2.725 0.9382 142.10 0.548 0.1343 26.069 (Gms) LIVER %FBW %BRAIN 19.602 6.5493 1020.4 18.739 6.4219 958.03 23.507 7.6371 1164.3 15.142 6.0111 784.56 16.174 6.3353 870.51 21.152 6.5751 1110.9 16.123 5.5905 865.43 19.200 6.6436 1025.1 23.017 7.2632 1208.2 17.945 6.6909 940.02 19.060 6.5718 994.75 2.863 0.5762 137.47 Company Sanitized. Does not contain TSCA CBJ FBW - Final Body Weight -817- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION ) DuPont-5990 Organ Weight Listing Group : II - 0 mg/kg/day Sex :FEMALES 1 ANIMAL OVARIES 1 (Gms) %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN THYMUS (Gms) %FBW %BRAIN THYROID GLAND (Gms) %FBW %BRAIN UTERUS (Gms) %FBW %BRAIN 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 0.131 0.0450 6.3377 0.152 0.0463 8.0637 0.100 0.0407 5.5835 0.139 0.0428 6.8104 0.136 0.0480 6.8068 0.123 0.0404 6.1965 0.160 0.0441 8.3247 0.157 0.0481 8.3289 0.110 0.0411 5.6295 0.131 0.0389 6.4310 0.464 0.1595 22.448 0.534 0.1627 28.329 0.442 0.1797 24.679 0.510 0.1571 24.988 0.527 0.1862 26.376 0.450 0.1477 22.670 0.634 0.1748 32.986 0.619 0.1896 32.838 0.602 0.2250 30.809 0.522 0.1552 25.626 0.251 0.0863 12.143 0.190 0.0579 10.080 0.179 0.0728 9.9944 0.376 0.1158 18.422 0.260 0.0918 13.013 0.239 0.0785 12.040 0.306 0.0844 15.921 0.256 0.0784 13.581 0.206 0.0770 10.542 0.200 0.0595 9.8184 0.020 0.0069 0.9676 0.013 0.0040 0.6897 0.018 0.0073 1.0050 0.013 0.0040 0.6369 0.017 0.0060 0.8509 0.018 0.0059 0.9068 0.022 0.0061 1.1446 0.021 0.0064 1.1141 0.013 0.0049 0.6653 0.011 0.0033 0.5400 1.485 0.5105 71.843 0.532 0.1621 28.223 1.124 0.4569 62.758 1.023 0.3152 50.122 0.615 0.2172 30.781 0.994 0.3263 50.076 0.702 0.1935 36.524 1.063 0.3256 56.393 0.877 0.3277 44.882 0.415 0.1234 20.373 Mean S.D. 0.134 0.0435 6.8513 0.020 0.0033 1.0433 0.530 0.1737 27.175 0.069 0.0228 3.9026 0.246 0.0802 12.556 0.060 0.0165 2.8220 0.017 0.0055 0.8521 0.004 0.0014 0.2105 0.883 0.2958 45.198 0.322 0.1245 16.259 Group : IV - 25 mg/kg/day Sex :FEMALES | ANIMAL | OVARIES | SPLEEN | THYMUS | THYROID GLAND | UTERUS 1 (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN 646502 646522 646567 646576 646595 646621 646635 646660 0.123 0.0491 6.4737 0.141 0.0483 7.2944 0.108 0.0330 5.3045 0.091 0.0260 4.8820 0.098 0.0353 5.0077 0.113 0.0325 5.5447 0.094 0.0318 4.8230 0.089 0.0348 5.1594 0.611 0.2441 32.158 0.636 0.2177 32.902 0.556 0.1700 27.308 0.591 0.1690 31.706 0.410 0.1475 20.950 0.643 0.1847 31.551 0.584 0.1976 29.964 0.450 0.1762 26.087 0.221 0.0883 11.632 0.210 0.0719 10.864 0.290 0.0887 14.244 0.266 0.0760 14.270 0.211 0.0759 10.782 0.517 0.1485 25.368 0.256 0.0866 13.135 0.235 0.0920 13.623 0.014 0.0056 0.7368 0.475 0.1898 25.000 0.021 0.0072 1.0864 0.641 0.2194 33.161 0.016 0.0049 0.7859 L 0.717 0.2193 35.216 0.016 0.0046 0.8584 0.832 0.2379 44.635 0.019 0.0068 0.9709 0.523 0.1882 26.725 0.016 0.0046 0.7851 0.914 0.2626 44.848 0.023 0.0078 1.1801 0.579 0.1959 29.708 0.020 0.0078 1.1594 0.678 0.2655 39.304 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -818- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION ) DuPont-5990 Organ Weight Listing Group : IV - 25 mg/kg/day Sex :FEMALES 1 ANIMAL 1 1 646664 1 646673 ji 1 Mean 1 S.D. OVARIES (Gms) %FBW %BRAIN 0.106 0.0353 5.2423 0.121 0.0459 5.6834 0.108 0.0372 5.5415 0.017 0.0078 0.7810 SPLEEN (Gms) %FBW %BRAIN 0.592 0.1973 29.278 0.604 0.2290 28.370 0.568 0.1933 29.027 0.077 0.0300 3.5989 THYMUS (Gms) %FBW %BRAIN 0.337 0.1123 16.667 0.189 0.0716 8.8774 0.273 0.0912 13.946 0.096 0.0235 4.5872 THYROID GLAND f UTERUS I (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN | 0.012 0.0040 0.5935 0.022 0.0083 1.0333 0.634 0.2113 31.355 1.148 0.4352 53.922 0.018 0.0062 0.9190 0.004 0.0016 0.1967 0.714 0.2425 36.387 0.202 0.0730 9.1915 Group : VI - 100 mg/kg/day Sex :FEMALES 1 ANIMAL 1 646501 646505 646510 646534 646556 646578 646608 646624 646629 646633 OVARIES (Gms) %FBW %BRAIN 0.109 0.0350 5.6128 0.126 0.0378 6.0694 0.099 0.0319 5.1429 0.111 0.0369 5.6260 0.075 0.0216 4.0475 0.152 0.0502 8.3288 0.147 0.0572 7.5578 0.114 0.0370 5.7373 0.106 0.0379 5.3481 0.160 0.0515 7.9523 SPLEEN (Gms) %FBW %BRAIN 0.599 0.1926 30.844 0.688 0.2066 33.141 0.644 0.2077 33.455 0.517 0.1717 26.204 0.606 0.1749 32.704 0.663 0.2190 36.329 0.556 0.2163 28.586 0.627 0.2038 31.555 0.510 0.1821 25.732 0.541 0.1742 26.889 THYMUS (Gms) %FBW %BRAIN 0.289 0.0929 14.882 0.274 0.0823 13.198 0.233 0.0751 12.104 0.223 0.0741 11.303 0.344 0.0993 18.564 0.268 0.0885 14.685 0.208 0.0809 10.694 0.340 0.1105 17.111 0.236 0.0843 11.907 0.251 0.0808 12.475 THYROID GLAND (Gms) %FBW %BRAIN 0.024 0.0077 1.2358 0.021 0.0063 1.0116 0.015 0.0048 0.7792 0.013 0.0043 0.6589 0.013 0.0038 0.7016 0.021 0.0069 1.1507 0.024 0.0093 1.2339 0.020 0.0065 1.0065 0.015 0.0054 0.7568 0.018 0.0058 0.8946 UTERUS 1 (Gms) %FBW %BRAIN | 0.739 0.2376 38.054 1.778 0.5339 85.645 0.738 0.2380 38.338 0.672 0.2232 34.060 0.825 0.2381 44.522 0.861 0.2843 47.178 0.603 0.2346 31.003 0.592 0.1924 29.794 0.641 0.2289 32.341 0.650 0.2093 32.306 Mean S.D. 0.120 0.0397 6.1423 0.026 0.0105 1.3660 0.595 0.1949 30.544 0.062 0.0181 3.5535 0.267 0.0869 13.692 0.047 0.0113 2.5812 0.018 0.0061 0.9430 0.004 0.0017 0.2173 0.810 0.2620 41.324 0.352 0.0984 16.609 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -819- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION > DuPont-5990 Organ Weight Listing Group : VIII - 500 mg/kg/day Sex FEMALES 1 ANIMAL ! 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 OVARIES (Gms) %FBW %BRAIN 0.132 0.0441 6.8714 0.131 0.0449 6.6973 0.114 0.0370 5.6464 0.131 0.0520 6.7876 0.138 0.0541 7.4273 0.130 0.0404 6.8277 0.090 0.0312 4.8309 0.109 0.0377 5.8195 0.088 0.0278 4.6194 0.089 0.0332 4.6621 SPLEEN (Gms) %FBW %BRAIN 0.585 0.1955 30.453 0.589 0.2019 30.112 0.562 0.1826 27.836 0.521 0.2068 26.995 0.558 0.2186 30.032 0.658 0.2045 34.559 0.597 0.2070 32.045 0.525 0.1817 28.030 0.646 0.2038 33.911 0.544 0.2028 28.497 THYMUS (Gms) %FBW %BRAIN 0.222 0.0742 11.556 0.221 0.0757 11.299 0.283 0.0919 14.017 0.222 0.0881 11.503 0.222 0.0870 11.948 0.251 0.0780 13.183 0.246 0.0853 13.205 0.243 0.0841 12.974 0.277 0.0874 14.541 0.261 0.0973 13.672 THYROID GLAND (Gms) %FBW %BRAIN 0.021 0.0070 1.0932 0.015 0.0051 0.7669 0.022 0.0071 1.0896 0.014 0.0056 0.7254 0.019 0.0074 1.0226 0.022 0.0068 1.1555 0.027 0.0094 1.4493 0.016 0.0055 0.8542 0.023 0.0073 1.2073 0.015 0.0056 0.7858 UTERUS | (Gms) %FBW %BRAIN | 0.986 0.3294 51.327 0.651 0.2231 33.282 0.826 0.2684 40.911 1.458 0.5788 75.544 0.737 0.2887 39.666 2.434 0.7566 127.84 0.484 0.1678 25.980 0.850 0.2941 45.382 2.523 0.7962 132.44 1.019 0.3799 53.379 Mean S.D. 0.115 0.0402 6.0190 0.020 0.0086 1.0438 0.579 0.2005 30.247 0.046 0.0113 2.5761 0.245 0.0849 12.790 0.023 0.0072 1.1460 0.019 0.0067 1.0150 0.004 0.0013 0.2312 1.197 0.4083 62.575 0.723 0.2228 38.015 Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight -820- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION ) DuPont-5990 Organ Weight Listing Group : II - 0 mg/kg/day Sex :FEMALES ANIMAL | FBW | BRAIN | ADRENAL GLANDS | HEART | KIDNEYS | LIVER | | (Gins) |(Gms) %FBW | (Gms) %FBW %BRAIN j (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 323.10 390.70 339.90 377.40 285.20 307.90 298.20 317.00 314.30 354.90 2.024 0.6264 1.971 0.5045 1.846 0.5431 1.977 0.5238 1.941 0.6806 2.008 0.6522 1.881 0.6308 1.880 0.5931 2.008 0.6389 1.984 0.5590 0.092 0.0285 4.5455 0.066 0.0169 3.3486 0.069 0.0203 3.7378 0.071 0.0188 3.5913 0.064 0.0224 3.2973 0.074 0.0240 3.6853 0.068 0.0228 3.6151 0.052 0.0164 2.7660 0.079 0.0251 3.9343 0.321 0.0904 16.179 1.209 0.3742 59.733 1.244 0.3184 63.115 1.084 0.3189 58.722 1.262 0.3344 63.834 1.006 0.3527 51.829 1.225 0.3979 61.006 1.223 0.4101 65.019 1.372 0.4328 72.979 1.198 0.3812 59.661 1.463 0.4122 73.740 2.296 0.7106 113.44 2.934 0.7510 148.86 2.455 0.7223 132.99 2.605 0.6902 131.77 2.078 0.7286 107.06 2.574 0.8360 128.19 2.210 0.7411 117.49 2.084 0.6574 110.85 2.626 0.8355 130.78 2.628 0.7405 132.46 9.500 2.9403 469.37 11.129 2.8485 564.64 9.643 2.8370 522.37 10.308 2.7313 521.40 7.242 2.5393 373.11 9.439 3.0656 470.07 9.151 3.0687 486.50 9.597 3.0274 510.48 9.450 3.0067 470.62 11.326 3.1913 570.87 Mean S.D. 330.86 1.952 0.5952 34.338 0.062 0.0597 0.096 0.0286 4.8700 0.080 0.0221 3.9999 1.229 0.3733 62.964 0.129 0.0408 6.5708 2.449 0.7413 125.39 9.679 2.9256 495.94 0.277 0.0568 12.861 1.134 0.1911 56.848 Group : VIII - 500 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW (Gms) 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 258.80 321.10 283.70 335.00 285.40 305.10 266.60 283.30 312.40 294.50 BRAIN (Gms) %FBW 1.923 0.7430 1.911 0.5951 1.939 0.6835 1.960 0.5851 1.945 0.6815 2.049 0.6716 1.913 0.7176 2.012 0.7102 2.005 0.6418 2.059 0.6992 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.066 0.0255 3.4321 0.087 0.0271 4.5526 0.074 0.0261 3.8164 0.073 0.0218 3.7245 0.063 0.0221 3.2391 0.084 0.0275 4.0996 0.081 0.0304 4.2342 0.078 0.0275 3.8767 0.088 0.0282 4.3890 0.070 0.0238 3.3997 Mean S.D. 294.59 1.972 0.6729 23.940 0.056 0.0515 0.076 0.0260 3.8764 0.009 0.0028 0.4416 HEART (Gms) %FBW %BRAIN 1.095 0.4231 56.942 1.274 0.3968 66.667 1.191 0.4198 61.423 1.506 0.4496 76.837 1.264 0.4429 64.987 1.427 0.4677 69.644 1.105 0.4145 57.763 1.073 0.3788 53.330 1.362 0.4360 67.930 1.111 0.3772 53.958 1.241 0.4206 62.948 0.152 0.0299 7.5949 KIDNEYS (Gms) %FBW %BRAIN 2.457 0.9494 127.77 2.803 0.8729 146.68 2.256 0.7952 116.35 3.123 0.9322 159.34 2.643 0.9261 135.89 2.572 0.8430 125.52 2.398 0.8995 125.35 2.568 0.9065 127.63 2.887 0.9241 143.99 2.554 0.8672 124.04 2.626 0.8916 133.26 0.253 0.0473 13.069 LIVER 1 (Gms) %FBW %BRAIN | 8.557 3.3064 444.98 12.484 3.8879 653.27 10.286 3.6257 530.48 14.498 4.3278 739.69 11.917 4.1755 612.70 13.308 4.3618 649.49 10.957 4.1099 572.77 11.281 3.9820 560.69 12.348 3.9526 615.86 12.431 4.2211 603.74 11.807 3.9951 598.37 1.651 0.3277 79.129 Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight -821 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN '.'/EIGHTS FOR FEMALE RA1 DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION DuPont-5990 Organ Weight Listing Group : II - 0 mg/kg/day Sex :FEMALES 1 ANIMAL 1 646511 646549 646551 646565 646580 646581 646586 646613 646627 646652 OVARIES (Gms) %FBW %BRAIN 0.094 0.0291 4.6443 0.101 0.0259 5.1243 0.127 0.0374 6.8797 0.125 0.0331 6.3227 0.116 0.0407 5.9763 0.114 0.0370 5.6773 0.095 0.0319 5.0505 0.133 0.0420 7.0745 0.087 0.0277 4.3327 0.102 0.0287 5.1411 SPLEEN (Gms) %FBW %BRAIN 0.678 0.2098 33.498 0.499 0.1277 25.317 0.597 0.1756 32.340 0.766 0.2030 38.746 0.516 0.1809 26.584 0.481 0.1562 23.954 0.456 0.1529 24.242 0.466 0.1470 24.787 0.441 0.1403 21.962 0.607 0.1710 30.595 THYMUS (Gms) %FBW %BRAIN 0.245 0.0758 12.105 0.229 0.0586 11.618 0.229 0.0674 12.405 0.200 0.0530 10.116 0.226 0.0792 11.643 0.211 0.0685 10.508 0.209 0.0701 11.111 0.189 0.0596 10.053 0.280 0.0891 13.944 0.239 0.0673 12.046 THYROID GLAND (Gms) %FBW %BRAIN 0.023 0.0071 1.1364 0.021 0.0054 1.0654 0.021 0.0062 1.1376 0.022 0.0058 1.1128 0.017 0.0060 0.8758 0.018 0.0058 0.8964 0.021 0.0070 1.1164 0.018 0.0057 0.9574 0.023 0.0073 1.1454 0.023 0.0065 1.1593 UTERUS 1 (Gms) %FBW %BRAIN | 0.990 0.3064 48.913 0.774 0.1981 39.269 0.948 0.2789 51.354 0.923 0.2446 46.687 0.600 0.2104 30.912 0.660 0.2144 32.869 0.826 0.2770 43.913 0.517 0.1631 27.500 0.775 0.2466 38.596 0.804 0.2265 40.524 Mean S.D. 0.109 0.0333 5.6223 0.016 0.0057 0.9271 0.551 0.1665 28.203 0.108 0.0266 5.3471 0.226 0.0689 11.555 0.026 0.0106 1.1835 0.021 0.0063 1.0603 0.002 0.0007 0.1086 0.782 0.2366 40.054 0.153 0.0430 7.8940 Group : VIII - 500 mg/kg/day Sex :FEMALES 1 ANIMAL 1 646506 646508 646540 646542 646545 646548 646599 646618 646637 646650 OVARIES (Gms) %FBW %BRAIN 0.131 0.0506 6.8123 0.102 0.0318 5.3375 0.093 0.0328 4.7963 0.094 0.0281 4.7959 0.090 0.0315 4.6272 0.110 0.0361 5.3685 0.062 0.0233 3.2410 0.147 0.0519 7.3062 0.144 0.0461 7.1820 0.131 0.0445 6.3623 SPLEEN (Gms) %FBW %BRAIN 0.517 0.1998 26.885 0.541 0.1685 28.310 0.503 0.1773 25.941 0.561 0.1675 28.622 0.524 0.1836 26.941 0.489 0.1603 23.865 0.402 0.1508 21.014 0-547 0.1931 27.187 0.608 0.1946 30.324 0.538 0.1827 26.129 THYMUS (Gms) %FBW %BRAIN 0.138 0.0533 7.1763 0.190 0.0592 9.9424 0.302 0.1065 15.575 0.236 0.0704 12.041 0.180 0.0631 9.2545 0.261 0.0855 12.738 0.210 0.0788 10.978 0.187 0.0660 9.2942 0.253 0.0810 12.618 0.244 0.0829 11.850 THYROID GLAND (Gms) %FBW %BRAIN 0.015 0.0058 0.7800 0.025 0.0078 1.3082 0.021 0.0074 1.0830 0.016 0.0048 0.8163 0.017 0.0060 0.8740 0.019 0.0062 0.9273 0.021 0.0079 1.0978 0.022 0.0078 1.0934 0.019 0.0061 0.9476 0.019 0.0065 0.9228 UTERUS 1 (Gms) %FBW %BRAIN | 1.104 0.4266 57.410 1.857 0.5783 97.174 0.863 0.3042 44.507 0.682 0.2036 34.796 0.967 0.3388 49.717 0.948 0.3107 46.266 0.843 0.3162 44.067 0.864 0.3050 42.942 0.530 0.1697 26.434 0.488 0.1657 23.701 Mean S.D. 0.110 0.0377 5.5829 0.027 0.0099 1.3076 0.523 0.1778 26.522 0.054 0.0159 2.5970 0.220 0.0747 11.147 0.048 0.0155 2.3537 0.019 0.0066 0.9851 0.003 0.0010 0.1598 0.915 0.3119 46.702 0.383 0.1240 20.491 Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight - 822 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR THREE-MONTH RECOVERY EVALUATION Organ Weight Listing Group : II - 0 mg/kg/day Sex .-FEMALES ANIMAL FBW KIDNEYS (Gms) (Gms) %FBW (Gms) LIVER %FBW 646507 646530 646588 646597 307.20 330.90 327.90 397.50 2.180 0.7096 1.997 0.6035 2.340 0.7136 2.790 0.7019 8.457 2.7529 8.110 2.4509 8.183 2.4956 10.456 2.6304 Mean S.D. 340.88 39.193 2.327 0.6822 0.339 0.0527 8.802 2.5825 1.113 0.1369 SPLEEN (Gms) %FBW 0.610 0.1986 0.430 0.1299 0.514 0.1568 0.484 0.1218 0.510 0.1518 0.075 0.0346 THYROID GLAND (Gms) %FBW 0.018 0.0059 0.019 0.0057 0.016 0.0049 0.022 0.0055 0.019 0.0055 0.002 0.0004 Group : IV - 25 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW KIDNEYS (Gms) (Gms) %FBW 646531 646568 646625 646626 646636 326.20 423.70 342.40 262.00 330.10 2.290 0.7020 2.812 0.6637 2.642 0.7716 1.988 0.7588 2.053 0.6219 Mean S.D. 336.88 57.739 2.357 0.7036 0.361 0.0631 1 1(Gms) LIVER %FBW 1 9.407 2.8838 1 11.521 2.7191 1 9.119 2.6633 1 8.330 3.1794 1 8.486 2.5707 1 1 9.373 2.8033 1 1.280 0.2391 SPLEEN (Gms) %FBW 0.518 0.1588 0.512 0.1208 0.477 0.1393 0.426 0.1626 0.444 0.1345 0.475 0.1432 0.041 0.0174 THYROID GLAND (Gms) %FBW 0.022 0.0067 0.021 0.0050 0.019 0.0055 0.020 0.0076 NW* 0.021 0.0062 0.001 0.0012 | 1 1 1 1 1 DuPont-5990 Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight 3Not weighed. Rationale documented in study records. - 823 - ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR THREE-MONTH RECOVERY EVALUATION Organ Weight Listing Group : VI - 100 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW (Gms) 646630 646632 646634 646656 405.00 311.20 288.40 381.70 KIDNEYS (Gms) %FBW 3.893 0.9612 2.700 0.8676 2.219 0.7694 2.540 0.6654 LIVER (Gms) %FBW 14.775 3.6481 10.756 3.4563 9.143 3.1702 10.958 2.8708 Mean S.D. 346.58 55.627 2.838 0.8159 0.731 0.1273 11.408 3.2864 2.387 0.3396 SPLEEN (Gms) %FBW 0.550 0.1358 0.491 0.1578 0.531 0.1841 0.604 0.1582 0.544 0.1590 0.047 0.0198 THYROID GLAND (Gms) %FBW 0.020 0.0049 * 0.018 0.0058 0.016 0.0055 0.017 0.0045 0.018 0.0052 0.002 0.0006 Group : VIII - 500 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW KIDNEYS (Gms) (Gms) %FBW LIVER (Gms) %FBW 646523 646528 646620 646667 255.00 357.70 318.40 307.30 2.276 0.8925 2.636 0.7369 2.651 0.8326 2.840 0.9242 9.441 3.7024 11.762 3.2882 10.140 3.1847 11.746 3.8223 Mean S.D. 309.60 42.338 2.601 0.8466 0.236 0.0824 10.772 3.4994 1.169 0.3104 SPLEEN (Gms) %FBW 0.549 0.2153 0.754 0.2108 0.594 0.1866 0.509 0.1656 0.602 0.1946 0.107 0.0231 THYROID GLAND (Gms) %FBW 0.013 0.0051 0.018 0.0050 0.020 0.0063 0.022 0.0072 0.018 0.0059 0.004 0.0010 | 1 | | ) DuPont-5990 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI - 824- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 APPENDIX N INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS -825Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS EXPLANATORY NOTES LESION GRADING: Histopathological changes are described according to their morphologic character, distribution and severity. The distribution (extent of tissue involvement) is indicated, where appropriate, by modifiers such as focal, multifocal, diffuse, unilateral, bilateral, etc. A severity score, if appropriate, is also assigned as follows: MINIMAL: The amount of change present barely exceeds that which is considered to be within normal limits. MILD: In general, the lesion is easily identified but of limited severity. The lesion probably does not produce any functional impairment. MODERATE: The lesion is prominent but there is significant potential for increased severity. Limited tissue or organ dysfunction is possible. SEVERE: The degree of change is either as complete as considered possible or great enough in intensity or extent to expect significant tissue or organ dysfunction. COMMENT : Grades minimal through severe represent progressive involvement/severity along a continuum with minimal lesions being the least severe and severe lesions being the most severe. While the grades refer to the morphological characteristics of lesions, they also indicate their relative biological significance. Gross observations listing multiple masses for a tissue are distinguished with letters (i.e., A, b, c, d, etc.). -826Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646325 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES Histopathology : LIVER : FATTY CHANGE, PERIPORTAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : SPLEEN, THYROID GLAND 646360 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646360 Continued on the next page .... -827Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646360 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV - 828 Compny Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646367 Terminal Sacrifice Killed on Day : 96 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV -829Company Sanitized. Does not contain TSCA CBi H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646371 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, ' AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN -830Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646374 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNG&, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. SPLEEN : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646374 Continued on the next page .... - 831 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646374 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646379 Terminal SacrificeKilled on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 646379 Continued on the next page .. - 832 Comparty Sanitized. Does not contain TSCA CBi H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646379 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. HYPERTROPHY, CENTRILOBULAR, minimal. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, `minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : MISSING. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV ORGANS NOT EXAMINED: PARATHYROID GLANDS - 833 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646396 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVfeR, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : SPLEEN, THYROID GLAND 646398 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646398 Continued on the next page - 834Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646398 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 1 Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN, THYROID GLAND 646411 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646411 Continued on the next page - 835 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646411 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN, THYROID GLAND 646416 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646416 Continued on the next page - 836Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646416 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, , SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : SPLEEN 646420 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : URINARY BLADDER : CALCULUS\CALCULI, severe. COAGULATING GLANDS : LARGE, LEFT, severe. 646420 Continued on the next page .... - 837 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646420 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODfc, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : FATTY CHANGE, PERIPORTAL, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. KIDNEYS : PYELONEPHRITIS, BILATERAL, mild. THYROID GLAND : ALTERATION, COLLOID, mild. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, moderate. SEMINAL VESICLES : INFLAMMATION, SUBACUTE/CHRONIC, mild. URINARY BLADDER : CALCULUS/CALCULI. HYPERPLASIA, TRANSITIONAL CELL, moderate. INFLAMMATION, SUBACUTE/CHRONIC, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN 646420 Continued on the next page .... - 838Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646420 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646427 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 646427 Continued on the next page .... - 839Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646427 Continued from previous page Histopathology LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646432 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646432 Continued on the next page .... - 840Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646432 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, FfOSE Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN 646446 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646446 Continued on the next page - 841 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646446 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E {S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN 646457 Unscheduled Sacrifice Duration of dosing-days: 57 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : SKIN : STAIN, RED, VENTRAL BODY, WET. URINARY BLADDER : DILATATION, RED, severe. 646457 Continued on the next page - 842 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646457 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, 'tfHYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, PROSTATE, SEMINAL VESICLES, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, mild. URINARY BLADDER : INFLAMMATION, SUBACUTE/CHRONIC, mild. HEMORRHAGE, moderate. CAUSE OF DEATH : KIDNEY: INFLAMMATION/OBSTRUCTION. No Microscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV - 843 Company Sanitized. Does not contain TSCA CBi H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646459 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN -844Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646460 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND 646468 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES 646468 Continued on the next page .... -845Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646468 Continued from previous page Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : * LIVER, SPLEEN, THYROID GLAND 646482 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal 646482 Continued on the next page .... - 846Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646482 Continued from previous page Histopathology : PARATHYROID GLANDS : MISSING. CAUSE OF DEATH : . SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV ORGANS NOT EXAMINED: PARATHYROID GLANDS 646485 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646485 Continued on the next page .... - 847Company Sanitized. Does not contain TSCA CBI H-24768: Subchionic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646485 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV - 848 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646487 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND - 849Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic Sc Macroscopic Findings 646489 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV - 850Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646492 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : , LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. EY E (S ) WITH OPTIC NERVE : HEMORRHAGE/INFLAMMATION (BLEEDING PROCEDURE), minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 646492 Continued on the next page ... - 851 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646492 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646494 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646494 Continued on the next page .... -852Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : I- 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646494 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN 646495 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy f Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : SPLEEN - 853Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646368 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER 646370 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646370 Continued on the next page .... -854Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646370 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, ft SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : SPLEEN 646399 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646399 Continued on the next page .... - 855 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646399 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN 646414 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646414 Continued on the next page - 856Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: III - 25 mg/kg/day Sex: Males Animal Ref Microscopic Sc Macroscopic Findings 646414 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE'JOINT, STERNUM, NOSE Histopathology LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN 646421 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND 646421 Continued on the next page .... - 857 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646421 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, severe. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN 646423 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646423 Continued on the next page - 858Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :; III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646423 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN 646426 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : URINARY BLADDER : CALCULUS\CALCULI. 646426 Continued on the next page - 859Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646426 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ,ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : HYDRONEPHROSIS, BILATERAL, mild. NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. URINARY BLADDER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA, TRANSITIONAL CELL, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN - 860Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646436 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES Histopathology THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN 646438 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES 646438 Continued on the next page -861 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646438 Continued from previous page Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN 646443 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : KIDNEYS : DILATATION, RIGHT, PELVIS. THYMUS : DISCOLORATION, BILATERAL. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, 646443 Continued on the next page .. .. - 862Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646443 Continued from previous page Gross Pathology .- No Macroscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E {S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, * URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. KIDNEYS : HYDRONEPHROSIS, UNILATERAL, mild. THYMUS : NO MICROSCOPIC EVIDENCE OF MACROSCOPIC FINDING. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : SPLEEN 646449 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES 646449 Continued on the next page - 863 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646449 Continued from previous page Histopathology LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : SPLEEN 646453 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, mild. THYROID GLAND : ALTERATION, COLLOID, moderate 646453 Continued on the next page .... - 864Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref 646453 Microscopic & Macroscopic Findings Continued from previous page Histopathology CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : SPLEEN 646454 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646454 Continued on the next page -865 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646454 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN 646458 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646458 Continued on the next page .... -866Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646458 Continued from previous page Histopathology No Microscopic Abnormality Observed : KIDNEYS, SPLEEN 646471 Terminal Sacrifice f Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646471 Continued on the next page .... - 867Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646471 Continued from previous page Histopathology No Microscopic Abnormality Observed : KIDNEYS - 868Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________________ DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646327 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID LANDS TESTES Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN 646335 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES 646335 Continued on the next page .... - 869Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646335 Continued from previous page Histopathology LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646349 Terminal Sacrifice Killed .on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 646349 Continued on the next page -870Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646349 Continued from previous page Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646373 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : LIVER : LARGE. WHOLE BODY : SITUS INVERSUS. No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 646373 Continued on the next page .... -871 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646373 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : HYPERTROPHY, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646376 Terminal -Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES 646376 Continued on the next page -872Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646376 Continued from previous page Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN . 646385 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 646385 Continued on the next page - 873 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group :: V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646385 Continued from previous page Histopathology LIVER : HYPERTROPHY, CENTRILOBULAR, mild. INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN 646403 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN 646403 Continued on the next page .... - 874Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646403 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, SPLEEN 646435 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYDRONEPHROSIS, UNILATERAL, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. PIGMENT INCREASED, minimal. 646435 Continued on the next page .... -875Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646435 Continued from previous page Histopathology THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. , CAUSE OF DEATH : SACRIFICE BY DESIGN. 646455 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. PIGMENT INCREASED, minimal 646455 Continued on the next page .... -876Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646455 Continued from previous page Histopathology THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. ' No Microscopic Abnormality Observed : KIDNEYS 646456 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal 646456 Continued on the next page .... -877Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646456 Continued from previous page Histopathology LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. PIGMENT INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS 646463 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day'Exposure Animal is signed off from necropsy Gross Pathology : KIDNEYS : DILATATION, RIGHT, PELVIS. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 646463 Continued on the next page - 878 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646463 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. NO MICROSCOPIC EVIDENCE OF MACROSCOPIC FINDING. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. PIGMENT INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. - 879Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646469 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART,' SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN - 880Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646472 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : PYELONEPHRITIS, BILATERAL, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. -881 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646477 Found Dead Duration of dosing-days: 51 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : EYE(S) WITH OPTIC NERVE : HEMORRHAGE, RIGHT, severe. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 646477 KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. JEJUNUM : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. ILEUM : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. THYROID GLAND : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. EY E (S ) WITH OPTIC NERVE : HEMORRHAGE/INFLAMMATION (BLEEDING PROCEDURE), Continued on the next page .... severe. - 882Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646477 Continued from previous page Histopathology PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. CAUSE OF DEATH : EYE: HEMORRHAGE/INFLAMMATION (BLEEDING PROCEDURE). No Microscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646488 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : KIDNEYS : DILATATION, RIGHT. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND 646488 Continued on the next page .... - 883 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646488 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : HYDRONEPHROSIS, UNILATERAL, mild. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : SPLEEN - 884Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646337 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. - 885 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646343 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : LIVER LARGE. No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. SPLEEN : PIGMENT INCREASED, minimal. HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646343 Continued on the next page .... - 886Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646343 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, ' SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646344 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646344 Continued on the next page .... - 887 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646344 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, SPLEEN 646346 Terminal Sacrifice Killed on Day : 95 * Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : LIVER : LARGE. STOMACH : ULCER/EROSION, GLANDULAR, FEW. No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. 646346 Continued on the next page .... - 888Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group . VII - 500 mg/kg/day Sex : Males Animal Ref Microscopic & Macroscopic Findings 646346 Continued from previous page Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. MANDIBULAR LYMPH NODE : CONGESTION, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. EYE(S ) WITH OPTIC NERVE : HEMORRHAGE/INFLAMMATION (BLEEDING PROCEDURE). CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV - 889Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646347 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646347 Continued on the next page .... -890Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646347 Continued from previous page Histopathology No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NOf)E, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646355 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN 646355 Continued on the next page .... - 891 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646355 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, SPLEEN 646361 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES Histopathology : LIVER : FATTY CHANGE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN - 892Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646364 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART,' SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. PIGMENT INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS - 893Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646369 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : ` LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN -894Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646372 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : SPLEEN - 895 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646380 Found Dead Duration of dosing-days: 31 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : KIDNEYS : DISCOLORATION, TAN,'LEFT. URINARY BLADDER : DILATATION, RED. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : PYELONEPHRITIS, BILATERAL, moderate. HYDRONEPHROSIS, BILATERAL, mild. SPLEEN : ATROPHY, LYMPHOID, mild. PHARYNX/LARYNX : MISSING. PROSTATE : MISSING. 646380 Continued on the next page .... -896Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646380 Continued from previous page Histopathology : URINARY BLADDER : INFLAMMATION, SUBACUTE/CHRONIC, moderate. HEMORRHAGE, moderate. CAUSE OF DEATH : KIDNEY: INFLAMMATION/OBSTRUCTION. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, E Y E (S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV ORGANS NOT EXAMINED: PHARYNX/LARYNX, PROSTATE 646384 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646384 Continued on the next page .... -897 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646384 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. PIGMENT INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646388 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : LIVER : LARGE. 646388 Continued on the next page -898Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646388 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : PIGMENT INCREASED, minimal. HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646388 Continued on the next page .... - 899Compny Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646388 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646391 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS, TESTES Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN -900Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646397 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month RecoveryAnimal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. PIGMENT INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. -901 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 645407 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : LIVER : ` LARGE. No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT,' STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, mild. SPLEEN : PIGMENT INCREASED, minimal. HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646407 Continued on the next page .... -902Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646407 Continued from previous page Histopathology No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVB, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III Sc IV 646413 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 646413 Continued on the next page -903Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646413 Continued from previous page Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. EY E (S ) WITH OPTIC NERVE : FOLD/ROSETTE, RETINAL, minimal. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646422 Unscheduled Sacrifice Duration of dosing-days: 28 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : KIDNEYS : DILATATION, LEFT, severe. 646422 Continued on the next page .... -904Compny Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646422 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYDRONEPHROSIS, UNILATERAL, severe. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : KIDNEY: INFLAMMATION/OBSTRUCTION. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, 646422 Continued on the next page -905Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646422 Continued from previous page Histopathology No Microscopic Abnormality Observed : ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646428 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. PIGMENT INCREASED, minimal 646428 Continued on the next page .... -906Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646428 Continued from previous page Histopathology THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SAfcRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER 646433 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : LIVER : LARGE. No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 646433 Continued on the next page -907Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646433 Continued from previous page Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. SPLEEN : PIGMENT INCREASED, minimal. HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. EYE(S ) WITH OPTIC NERVE : FOLD/ROSETTE, RETINAL, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646437 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : SKIN : ALOPECIA, PERINEUM. 646437 Continued on the next page .... -908Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646437 Continued from previous page Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. SKIN : ALOPECIA/HYPOTRICHOSIS, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. 646437 Continued on the next page .... -909Compny Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646437 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646442 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 646442 Continued on the next page .. -910Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646442 Continued from previous page Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. KIDNEYS : INFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. NEPHROPATHY, CHRONIC PROGRESSIVE, minimal*. SPLEEN : PIGMENT INCREASED, minimal. HEMATOPOIESIS, INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III &. IV -911 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646448 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER,' KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. PIGMENT INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. -912Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________________ DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646466 Terminal Sacrifice Killed on Day : 183 Exposure Group : 3-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, SPLEEN, THYROID GLAND, PARATHYROID GLANDS TESTES Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER, SPLEEN 646474 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 646474 Continued on the next page .... -913Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646474 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : HYPERTROPHY, CENTRILOBULAR, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. PIGMENT INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : KIDNEYS 646475 Terminal Sacrifice Killed on Day : 95 Exposure Group : 90-Day Exposure Animal is signed off from necropsy Gross Pathology : STOMACH : ULCER/EROSION, GLANDULAR, FEW, minimal 646475 Continued on the next page .... -914Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646475 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, ' SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : PIGMENT INCREASED, minimal. HEMATOPOIESIS, INCREASED, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. HEMORRHAGE/INFLAMMATION (BLEEDING PROCEDURE). CAUSE OF DEATH : SACRIFICE BY DESIGN. 646475 Continued on the next page .... -915 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646475 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE III & IV 646484 Terminal Sacrifice Killed on Day : 123 Exposure Group : 1-Month Recovery Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 646484 Continued on the next page .. -916Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5990 Dose Group : VII - 500 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 646484 Continued from previous page Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEEN : HEMATOPOIESIS, INCREASED, minimal. PIGMENT.INCREASED, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. CAUSE OF DEATH : SACRIFICE BY DESIGN. No Microscopic Abnormality Observed : LIVER -917 Company Sanitized. Does not contain TSCA CBI