Document renp01M1GOjDZjJ6qOLdGL6QJ

Current Intelligence Pors y. Ccr.orc, 14th Juiici.il ' - -Calcasieu Farisii, Lcuisiur.a Xo make an early determination of the distribution and extent of primary liver cancer, and more specifically, angiosarcoma of the liver among workers exposed to vinyl chloride, the National Institute for Occupational Safety and Health (NIOSH), Center tor Disease Control, has requested members of the medical community in the United States and abroad to report information on known or suspected cases As shown in the table, 26 cases have been reponed to date from six countries. Sixteen of these are from the United States. Although cases have been ob served from four distinct work areas, the majority (81%) were formerly employed as reactor cleaners at plants where vinyl chloride was transformed into polyvinyl rKInnHa (nuftaan r*j(oc angiosarcoma or me nver have been reported from four polymerization plants in the United States. While an exact estimate of the risk for polymerization workers must await completion of follow-up. it is already apparent that the disease rate for this group is extremely high. The total work force currently em ployed at U.S. polymerization plants is about 5,000. No adequate data on pnor vinyl chloride exposure levels of polymerization workers is available, but it is thought that past exposures may have frequently exceeded the TLV of 500 ppm. For the polymerization workers the median age at diagnosis of angiosar coma of the liver is 45 years with a range from 36 to 71 years, and the median in terval from first exposure to diagnosis is 20 years with a range from 11 to 30 years. Too few cases have been reported from the other work areas to provide stable estimates of age and latency. Persons interested in obtaining further information should contact j. William Lloyd. Sc.D., Director, Office of Oc cupational Health Surveillance and Biometrics, NIOSH, 5600 Fishers Lane. Room 3-32, Park Building, Rockville, MD 20652. Angiosarcoma of the Liver in Vinyl Chloride/Polyvinyl Chloride Workers Tabte 1. -- Reported Cam of liver Anfiosarcoma in Workers Exposed ta Vinyl Chloride or Polyvinyl Chloride. Conakry Sweat Chechoslovakia Great Britain Norway Sweden Umted States U*>'ed States UmtM Slim United States Umirt Stun United State United State United State Unnd Sum Unite State Unite Sum Umtod State Unite State UmM SMB W Germany W Germany Great Britain UmM sum UmM Sum W Ommmt Cm to. 1ft VC 01 A| Trs Birth or PVC tat* at If* tip. Dt Itpeturo Stroma DX to DX VC Monomer Preuctie Markers 02* 1127-11 00 0045 OS-1572 61 27 Prtymeriutidn MrUfi nt AWilTINft nrraii c :: miet iing Of 00 00 01 00 00 46 12 00 72 01* 12 23 15 03-00 50 12 20 71 or 062327 01 14-51 C2 00 70 Of 10 1723 12 0948 03-03-73 or 08 1933 11 1555 05 00-70 or 0525 15 11 2845 1213 73 04* 01 15-24 07 06 52 08 1967 05* 012512 06 19 44 04 09 64 N' 00-00-20 01 1752 02 00 74 07* 05-03 22 08 0044 00 0068 Of 05 06-20 10 0746 010041 w 00 0031 05 2645 0301 74 10* 081613 06 12 51 05 00 68 If 05 2700 10 1446 0300-70 12- 11 1711 09 1340 050269 13* 12 01 21 08 19 44 050074 110427 05 00 50 00 00 69 01 07 26 31 16-14-57 00-00-71 02 06 04 30 1001 57 00 00 69 ;i 56 43 49 36 58 43 52 45 45 41 43 55 61 50 53 41 40 33 26 22 19 22 14 28 15 20 12 24 IS 29 17 23 20 30 17 14 It Compounders, fahreatert, Etc or 000114 000046 02 0070 55 14 00 00 13 08 1 8 38 0600 73 60 15- 000020 00-00 00 07 00 72 47 74 36 OO KOtter Emma 03 oooooo oooooo 00-00-00 43 14 Tot Tn Date e( tw Oeath 23 00-14-72 20 12-0072 21 010472 18 10 20 70 16 03 03 73 13 09 2871 28 12 19-73 15 01-07 68 18 04 0944 12 WIVE 18 03 23-68 15 08 2941 17 ALIVE 17 05-10-68 23 03 16 70 IS 05 02 69 30 07-0474 4 032749 14 1214-71 11 01 2549 11 12 00 70 Mote 1 00 07 03 73 Hon 2 t 5 2GO 02 1573 Note 00 30-00-00 N*t 4 holt 1 Pouring PVC oil nurture onto bone bases Not* 2 Machine operator covermg otoctncat wire *<th PVC plastic insulation Not* 3 Accountant at smrrt MOncation plants (work history under review) Koto 4 loemi ecstiado cans with VC propellant Mato 5 OnfMUt Sarcoma (possiMy an|iosareema V hour Possibly at fonoratned neoplasm of the reKutendothelia! cell >i * ' Mkam teOmwcUl* cMiteO |iourcwiu of Ifco Mr "Of' Mcmt uManm Salt CMrt 013908 Journal of Occupational Medicine/Vol. 16, No. 12/December 1974 809 BFG62655 APPENDIX A iK' iv ky ' V r* C* Current Intelligence Subject to rrotsct^vs Order in ^oss v Conoco, Inc., No. 90 - 4837 . 14th Judicial District Court (' Calcasieu Parish, Louisiana To make an early determination of the distribution and extent of primary liver cancer, and more specifically, angiosarcoma of the liver among workers exposed to vinyl chloride, the National Institute for Occupational Safety and Health (NIOSH). Center tor Disease Control, has requested members of the medical community in the United States and abroad to report information on known or suspected cases. As shown in the table, 26 cases have been reported to date from six countries. Sixteen of these are from the United States. Although cases have been ob served from four distinct work areas, the majority (81%) were formerly employed as reactor cleaners at plants where vinyl chloride was transformed into polyvinyl rKinriHA FrujftMn rscac a# angiosarcoma or tne liver have been reported from four polymerization plants in the United States. While an exact estimate of the risk for polymerization workers must await completion of follow-up, it is already apparent that the disease rate for this group is extremely high. The total work force currently em ployed at U S. polymerization plants is about 5,000. No adequate data on pnor vinyl chloride exposure levels of polymerization workers is available, but it is thought that past exposures may have frequently exceeded the TLV of 500 ppm. For the polymerization workers the median age at diagnosis of angiosar coma of the liver is 45 years with a range from 36 to 71 years, and the median in terval from first exposure to diagnosis is 20 years with a range from 11 to 30 years. Too few cases have been reported from the other work areas to provide stable estimates of age and latency. Persons interested in obtaining further information should contact |. William Lloyd, Sc.D., Director. Office of Oc cupational Health Surveillance and Biometrics. NIOSH. 5600 Fishers Lane. Room 3-32, Park Building, Rockville, MO 208S2. Angiosarcoma of the Liver in Vinyl Chloride/Polyvinyl Chloride Workers TaM* 1. -- lirM Cans af linr ta|iaurcaffla i Marian limit ta Viitjt Cklarida ar Polyvinyl CklenO*. CmMry haa CrtctosiovafeiA Grot 8riUta Norm* SdM Uiwtai Staas U-i'rt Slaaa Umiad Sum Uatlaa States UattO Slaaa Uartta Stataa UmM SUM Uiutrt Staat Urnst Staas Uwtrt Stataa UnittO Staas Umtad Staas UmM Stataa UmM SUM IV. Gtraimij W Sarmair Craa Intaki UntaS Starts UmS Staas W. Caaaa Cm M Birtfe Ma W 11-27*11 ia K a rw SI bf it Trs At li* Dp. (Min Isrcwai 01 ta 01 9C UawMr PrafectM Hariri 51008045 05-15-72 27 PrtyMriatm* Mrfears ft! AWAITING nrrsiiR :: emtiinw aCinuo or 004001 00 00 46 12 00 72 71 01* 1223 15 0340 50 12 20 71 54 01- 04 23 27 0814-51 02-00 70 43 01- 101723 12 09-40 0343-73 45 0?* 00-10-33 a 15 55 05 00-70 34 03* 05-25 15 11 2445 121373 ss 04- 0115-24 07 44 52 0819-87 43 05' 012512 94 1944 04 0944 52 or 0040-25 01 1742 02 40 74 45 or 09-0322 08 0044 0040-88 45 or 05 00-20 100744 080041 41 or 00-00-31 052845 0341 74 43 ir 00-1413 081231 054088 55 a* 052701 101444 0340-70 61 ir 111711 091345 050249 50 ir 124121 00 19 44 05 00 74 53 ir 1144 27 0540 50 00 0089 41 01 07 2031 111457 0040-71 40 00 04 30 100157 00-0049 39 24 22 19 22 14 21 15 20 12 24 IS 29 17 23 20 30 17 14 11 CawmWiri, Fafencatsn. (tc. or 0041-14 004040 0200-70 55 14 004013 001138 0440 73 80 is- 004025 004040 07 00 72 47 24 30 00 Olka VC (masaa 01 004040 004040 004040 43 14 Tat Trs oat a ta*. Daatfe 21 00-10-72 20 1240 72 21 0144 72 11 1020 70 14 030373 13 09 21 71 28 1219 73 15 014741 11 044944 12 ALIVE 18 032388 15 01-2941 17 LIVE 17 05-1088 23 03 1470 15 050249 30 0784-74 4 032749 14 1214-71 11 01 2549 a 1240 70 Ma 1 00 070373 NaH 2 1 5 00 302 IS 73 Ma 00 004040 Mi 4 Ma 1 Nanai EVC ail rnitara oata baric Saw Mala 2 Mac*iat aaaratar ceaanai aatncal aa WC aiaatic MMiaftea IMi ) tanataat a mara Mncana giaati (work kiartn sirte* ram) data 4 LaaSiai mania earn art VC progallaat Ma 5 Dtamaat Sarcam (aauiMr aaimarcama') Inar. VowMii? a (aaaraltraa aaoatai* af ike retmteaiiaiitlia! eaS CMA 013908 Journal of Occupational Medicine/Vot. 16, No. 12/December 1974 809 BFG62656 APPENDIX A N o(Vi t*v^* t* V